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Р?. 1

З???я ? ???е ???? ???в ???? ??????? ???е ???ия ??? ??? ??, ? ?е ?и
?????и, ??????и, а ???е – ??????и ????и ?я?? в ?? ????.

С?? ??? ?я ?с ? ??оя????, ?о ?е ??? ??? “???я” и ???е к ?? ?? ???в
“в??й” ????ы ? ??? ???????у ???у и ???ию у ?ех ???л (“?????я ??ь”).

И ??? ?е ?? ???? ???в ????ляют ??й ?????ую ??ь а???а, ???ляю?ю ?о ????ую
??????ь. В э?х ???х ?? ???и, ???е ??ую?я “????????? ???я?” (на ?с. –
??????).

В ?х ???ия ???л, ?????х ?я ????х ????в, ???? я?о в???ы. В ??? ?? ????
???в ?и ???ют ??е ???е “??ья”.

М?? ???ь, ?о ??? ??ь ?я???ся ???н. Т?? ??????е ??о ?я?е ??????е ??е ??,
?к ???ь ???????ь ?н??й ???? ??? ? ???л ??? со ?я??? с ?м ????м (????м
К).

А??з ??????? ???л, ?о ???? ???? ??т в “???” ???и ????я и ????е ? ??и
???? и ??????уют с ??????и ??????? в ????????й ???и.

На ?с. ???ж?а ???????ая ?????ия ??? ? в?????х ???? ???в IgGl. П?????ая
???а ? 104 ?????т ???? ?к, ?о ?и ? ???х???х (????????х) ???а ??дят ?
?????ь ??? ???? в ??й ????и, ???я ?? ? ???в “??ья” ?я?.

Т??? ? э?м ? ???е ????? ??а ????ия с ??? ???м ?????и ?й ? ??и, ???ю?м
??? ??н. А??????й ??? ????????х ???? ? ??х ???х, ????, ???. Но “???” ?
??е ??? ??и ???? ???ла я?я?ся ??? ??? “у??я” ? ??? ??и.

Н???????ю ???ь ????я и ?я???я ???? в “?е?е” на ??е ??и ???ют ??о 20
?????т. Но ?е ? ??е 70 ?????т ???о ? ???? ???в ???уют в ?????и ????????
?????? э?й ???и.

Но ???ся к ??й пр???е ???ия ???о-??н?й ???и. П?я?а ?????ь ????? ???х ?
??? ???в. Из ????и ????????о ???а, ???ля?? ????м ???? ???я ???ют ????ю
???ю ?????.

З?? ? ???ряют, ???? ????ают ? ?? и ??сят в ??? ?6,5 ? ???у ДЕАЕ-??ю??.
П? ??м ???? ? IgG ? ??????я ? ???е и ???т ??у ????м, п???? ?е ??? ????ы
??ю?я ? ???е.

О?????о ??????ют ???у на ??? BrCN-??????? ???? и ???уют ? ?й ??к, ???м
?л ??????н ???. Р??? ????й ???и IgG ????ют ??з э? ???у и ???ают ? ?ф??.
В ????? ? ???е ????аю?я ??? ????, ?????е ?я э?? ??а-????. Их ??о ?я?
0,1М ????м ???? ???ы ?и 4,5М ????м MgClg. П???н? ??м ???м ???р ??? ???л
н????уют, ???уют ? ??й и, ?? ??, ?????уют ?????м ??.

Т??ь ??? ????й ???. К? ?я?? э? ??т?а с ???? ?е ??й ???и, ??? ?к, ??ы ?
????? их ????ая ????? и ??????ь? Н???й ???!

Но ?т ???а ???а ??????ям ????й ???к. Ок???ь, ?о ??й ??к ? ???? ??е?и
Staphylococcus aureus, ??а?? “??? А”, ???? ??? ?я???ся с ????? ??ью
(“????”) ?????а IgG.

За ??? “????ь” ????ся ???. Вряд ? ??к с ??м ????м ????? ??? ??? у э?й
????. С??е ??о е? ????? ????. (Но, ?к ???т ????а, ??? ?т, ?о ??т ? ?, ?о
?дят ?е, ? ???? ?, ?о ? ???л н??!).

Т? ?и ??е, ? ?????е ????? ???? ??а А ???о ?? к ??????ю ????? э?? ??й
????ы. На ???у ??????? ???? ????и ??? ??ют ??к А (?? ?? в ???е ???я
“Protein А – Sepharose CL-4В”) и ??з ?е в ?????? ???ях ????ют ???р
?е????? ???л. О? ???ляю?я ? ???е ??з ?? “???и” и ??к А.

О? ??а ?????ия ??ю?я с????и. К??? ??? – ??? ???? ??????т ?я ?????й ???и
? лю?й ???? ??и ?? ??а, ???й ?л ?????н ?я ?????и ???а. Сня? ?о с ???и
??е ???и ? ????ля? ??а – ???? ?и ??ю…

А???е ??????? ??и ???е ????? и, ??? ???ь, ? т??о ?я ???и ???. В 1978 г.
Stumphet ??? э?м ???м ? ??и ????? я??? ДНК ???? ????е ДНК-РНК ??и. По
э?м ???? ????? ??, ??????е ? ??? ??????х РНК. (К??? в э?м ??? ???????
д????? ??????м ???? ?л?????й ???ы и ????????????? ???ы) О????, ?о ?к?
??? ???о ????т в ????и с?????? ???л ??? ДНК-РНК.

О???? ??г?а ??е э?????? ??и ???

Э? – ?е о?н ??? ???? ???т ??????я ?????????? ?я???я ???л с ? ?????.
П????м ??, ?о ??е ????ия ??и ??? э?к????? в ПААГ ????ся ???е ??о ????
??с, ? ???х ?? ??? ????ь ???й ??к.

З?? ??о ?????? ????е ???????и ?????????? ?я???я с ??ь ??????? ????
??????я ???????и. И???ую?м ??????я ??? ?????ют ???а и о??ют ? ?о ??и
??????у. Р????? и ???я в ???е ?????я, ?к ????ая “?????а”.

О? ???? ?????ью ? ??м ???? ?????? ?????й ????? ?я?ю ????ня? лю?е ??и.

По ????и э?????? с ???й ?????и ?ля ??????? ???й у?ляют ???к ??и и ??? ?
н?о ?????у, ?????? ? ????е ? ?? ????и ? ?? ??м ??? и ?ля. П?? э? ??, ??м
??, ???ют в ???у “????а”, ?я ???? ДНК ? ????? ?ля ? ????лю??? ???.

То ?? ??? ?? ? ?? ???й ??????? ???, ??оя?о ?????й ???м, а ? ?????у
??а??ют ??? ??????? ??? и ??з ????у ??? ???ают ???. Т?? ????, ??? ??х ?
???я?м, ??ь ??? ? ??? п??ы п????ся ? ?????у и ?м ??? ?????я.

Н???????е ?????ы ??у ????и “????и” ???ают ?????? в 10% -?м ???? э?????,
???й в ????ях с ?????? ????т ??к. З?? ?????у ???ют в ???р п????й ??е
????р?? и ????ают 12 ??в ?и 37°С.

За э? ??я ?????я ???я ?я???я ??????х ???л, ?ею??я в ??????е с ??????м ?
??? ????м. (Для ?? ????х ??? в ??????е, – ?? ????й, – ?т ??????х ???л)
О????я ????? ?т??а ???ют ???м.

Н???, ?????у, ? ???й ???я ???а ???? ??а ??? ? ?я????я с ?м ?????, ????ют
2 ?? ?и 37°С в ???? ???? р?????? й?? ??а А (? ???? в ?? ???го ????а).

Не ??????й ? “???ях” ???л ??к А ???ют ???м ???м ????м. Б??у ??т и ???м
?т?????? (????м в ??ую?й ??е) ? ??????й ??? ????ют ????е ??? ???? б??.
Для ??е?ю?? ?????о ????ия ??? с ?а????й (а ??з ?е и с ??м), ? ??? ??д
???????? ??ют ?е ???и ??????? ????и.

Р?????? и???, ?????? в ????

Я??? ??????? ???а ??а?ся в ???? ??е ???, и ?т?у ????ую ???у ???????и ?
?е? ??????ь ? ??м. П???лю ??? ? ??????? э?? я??ия, ???е ?????ы ?я ?????о
????я.

1. И???ы ?и ?? ??????? ????я: а, (3 и у. ?-???ы ????ляют ??й я?а ??я;
(З-???ы – э? ???е э???? (Р-э????) и у – ??ь ???????е э???????е ????. В
???? ?п??ую?я ??? ?а ????х ??.

2. Р-э???? ???аю?я я??и ??? и ??? ????? ???? ?????ую?х ?????н? ???? (?
?????и и ????? ?я?) ?и э?м ? ??няю?я.

3. И?????? ????я лю?? ??????? ????а ?????я ? ????, ????у ?????я ??о ???,
????х к ???к???у ???у в ??и с ??, в ???х ? ?е ????л. С???ь э?? ????ия
???????я ?к ????ым ???? ?????а (ТУ).

То ?? ????, ? ???е лю?е ??? ????? ???а (а с ?м и ?????с? ????я) ?????я
?в?. О???о, ?о э? ??????? ???ся ????? в т??? ??о “???а ??и” э?? ???а.
В?мя ?????а ?я ????х ???? ????ся в ??ь ???х ????.

Для ????, ?????? в ??о?и, – ? ????? ??к ? ????? ?сяч ?т (?. ???у ?же).
З??я ???? ТУ ??ь ?????о: в ??х ??аях ?? ?и ????? ???? ??????? ????а
??????ь ?о ????я ?????и ? ??ня?ся, в ??? – ?а ??т ?а?ь ??и ? ?ля ? ??
???.

4. И?????? ????я ???о ??????? ????а в ??? ??? ???и ???????я ??? ??????х
???? (??в ????я) в ???. Е? ?? ??о ???ют в ???? “Кю?” (Ки). Э? – ??ь ???я
???а.1Ки==2,2 1012 ???? в м??у.

Д??я ????, ??я?я в ???е ??? СИ, ????ь, ????, ???м м?а: 1 Б???? (Бк) = 1
???у в ???у. Поэ?? ? ?х ?р ??????ь ?????ют ???? ч??м ???ю? (?и) ?и ???ю?
(?Ки).

5. П?????й ???с ?е???я? ???ая р??????? (УА), т.е. ???????ь 1 ????я
??????? ????, в ???м ??ь ??? ?е ????ла ??????й ???. Кр?е ??, в ???яю?м
?????е ???в ???о ??????е ???ы ???ляют ?? ??т?ую ?лю от ??? ??а ??? (?и
???л) ????, ???м?о ??????м. УА ???ют в ???? Ки/??ь ?и ?и/??ь.

6. О?? ??? ???????й ??????? ????я я?я?ся э??ия ???ю?х ??? (у-????е ??
????? ??л??и ??ия? э??? – “у-????”). И Р-э????, и у-???, ?????е ?????
???и ??го и ?? ? ??????? ????а, ??т ??ь ??? ???? э???.

В ???? ??????? ???а ??я? ????ь ???? ?????о ??о?? э??? ?????ую?х ??? ?и
???в. Ее ???ют в “э?????ь?х” (эВ) ?и ??э??????? (КэВ). Из ??а ??? ????,
?о 1эВ ??????т э???, ??????й э????м ?и ???е в ???е ??ряю?? э??????о ?ля
с р???ью ??н??? в 1 В??.

В ????ую?й ???е ???ы в? э? ??? ?я ????, ?????? в ????.

И??пТУзУА (Ки/??ь) Э??ия (КэВ) Р-э????в, Emaxу-????я”Н12,3
?т2919-14^5730 ?т62 (?и/??ь) 156-35g87,4 ?т. 1 500167-32р14,3 ?т. 9
0001708,-125J60 ?т. 2 000635131J8 ?т. 16 000250-81080-720

(Ц??, ?оя?я ??а ??? у ?????о ???а ???а, ????т ?о ??у в ???? ??ы ??а
?????о ????. О? ??т ?? ??? ?и ??? ??ы ????т?ю?? ???????? ??а. О?я??? э??
– в ??е ???)

И??а УА ????а ???ют ? в Кю?, а ??? ????в в ??? (?п/?н), ???е ?????? ???,
и ??сят ? к ????ю, а к ?????у и? ?????у ???? (?п/?н/?). С??о ??ря, э?
?????о, ?к ?к ?лю?ет сю? э?????? ??а ????в, ???я ??т ?? ??? ? ??????й.

Но ?я ??????х ????й, н???р, ?я ??ю??я ? ??м ???и и???????, ?????? ????
??а – ??? ????о. К?? ??, ???????ь ч?е ??о ????ют ?я “??????ия” – ????я
???х ????? ?????? ???ы ? ??х ?, ? ? ???х. З?? э?????? ?е? ? ?????а.

С??? ??в?ь ?? ??т в ?м, ?о ????е в ???е ???ия ?????? э??? ???ы ?я
?????ния э??????х ?????? (?????я ??з ????) ???о ? ????, ? ?ню? ?
????ляют э??ию ?????а ???о ?????х ??? ?и ???в.

Э? ??? ??о ? ???? ??????я ? э??иям э????в, ?????н?х ? ?с. По ?ям ???с ?
э?х ???? ???? ???? э??? в КэВ, ?????о, в ??? ????х (?. ??ы). По ?ям ???т
??????е ????? э?кт??в ????й э???. (К??е ? ??дят ? ?и ???т, ?к ?к э???
э????в, ???е к ?лю ? ??аю?я ????ю) У???? ???ия Е ?????уют ???й ???? э???
э????в ?????ую?? ???а, ? ???ю ???т ???????я ?и ??? ?????? ? ??с???.

picscalex990100090000033eba0000000019ba000000000400000003010800050000000
b0200000000050000000c023b009701030000001e00040000000701040019ba0000410b2
000cc0074002c03000000003a00960100000000280000002c03000074000000010008000
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