OE?A?INUeEA AEAAeAI?ss AA?A?IEO IAOE

?INOEOOO NAEIA?NOAA OAAI

AA?EAEI Ethaia Aieiaeeie??aia

OAeE 612.11-612.6

A?EIA? INIAEEAINO? ACA?IIAe?? A?EO?IOeEO?A

OA EAEEIOeEO?A E?IA? ETHAeEIE

03.00.13 — o?c?ieia?y ethaeeie oa oaa?ei

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Iieoaaa — 1999

Aeena?oaoe?y ? ?oeiien.

?iaioa aeeiiaia o Oeaio?aeuei?e iaoeiai-aeine?aei?e eaai?aoi???
Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai?? (i. Iieoaaa)

Iaoeiaee ea??aiee — eaiaeeaeao iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee, EAEAeAOAA ?AI? IAO?IAE*, Oe?a?inueea iaaee/ia
noiiaoieia?/ia aeaaeai?y caa?aeoaa/ Oeaio?aeueii? iaoeiai-aeine?aeii?
eaai?aoi???

Io?oe?ei? iiiiaioe: — aeieoi? a?ieia?/ieo iaoe, i?ioani?, ?EAAEUe*AIEI
AIEIAeEIE? EI?I?EIAE*,

Ee?anueeee aea?aeaaiee oi?aa?neoao ?i. Oa?ana Oaa/aiea, caa?aeoaa/
eaai?aoi??? iaia?aiieia??;

— eaiaeeaeao a?ieia?/ieo iaoe, aeioeaio eaoaae?e ii?iaeueii? o?c?ieia??
CAII?IAEAOeUe OAOssIA IEEIEAEIAIA, Oe?a?inueea iaaee/ia noiiaoieia?/ia
aeaaeai?y

I?ia?aeia onoaiiaa — Oa?e?anueeee iaaee/iee oi?aa?neoao, eaoaae?a
ii?iaeueii? o?c?ieia??

Caoeno a?aeaoaeaoueny 5 aa?aciy 1999 ?ieo

i 10 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee

E.44.351.01 i?e ?inoeooo? naeia?noaa OAAI ca aae?anith:

314006, i. Iieoaaa, Oaaaenueea iiaeea.

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo naeia?noaa
OAAI, i. Iieoaaa, Oaaaenueea iiaeea.

Aaoi?aoa?ao ?ic?neaiee 2 ethoiai 1999 ?. a/aiee nae?aoa?
niaoe?ae?ciaaii? ?aaee,

eaiaeeaeao a?ieia?/ieo iaoe I?aeoa?aaa I.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE.

AEOOAEUeI?NOUe OAIE. No/ania oyaeaiiy i?i no?oeoo?o a?ieia?/ieo iaia?ai
?ice?eaa? ?o aecia/io ?ieue a caaacia/aii? oa ?aaoeyoe?? o?c?ieia?/ii?
aeoeaiino? ee?oei i?aai?cio. [?aiiiii?o N., 1986]. Inoaii?i /anii
cia/io oaaao i?eaa?ioee aeine?aeaeaiiy ?ioiiiiaeoethth/eo aeanoeainoae
iaia?ai [Eenaeaaa A.O., *a?iuoaiei E.A., ?aaeceoianeee A.I., Eaenaae/
E.A.,1994; Eiceia A.A.1998; Eiyi N., Oi?ae I., Iae-Eeanee ?.,1983].
A?aoiaoth/e, ui iaeiei c iniiaieo eiiiiiaio?a o?c?ieia?/iiai ioi/aiiy
?ioiioeeo?a a?eo?ioeeoe, aeine?aeaeaiiy ?ioiiiiaeoethth/eo aeanoeainoae
a?eo?ioeeoa?ieo iaia?ai iaaoei cia/iiai ?iciianthaeaeaiiy [Eaeaeaoaa
I.I.,1996; EiceiaA.A.,1998]

A?eo?ioeeo — nai???aeia ?ioiieiiiaoaioia ee?oeia aiane?aeie ?nioaaiiy ia
?? iiaa?oi? ?aoeaioi??a aei aoii?aeueieo ?ioiieo /eiiee?a oa ni?aoe?? ia
iiaa?oi? aiaeiaaiieo ?ioiiiiaeoeyoi??a. Ci?ia aeanoeainoae
a?eo?ioeeoa?ii? iiaa?oi? iiaea aeeeeeaoe ??ciiiai?oi? ii?ooaiiy ooieoe??
?ioiii? nenoaie [Eaeaeaoaa ?.I.,1996]. Iiaa?oiaa? aetheii?ioa?aee
iaia?ai caeaoi? caaacia/oaaoe aca?iiae?th a?eo?ioeeo?a c e?ioioeeoaie oa
iie?ii?oiiyaea?ieie eaeeioeeoaie. Iniiaith oe??? aca?iiae?? ? iiyaa
aeaianeiaaieo, aiane?aeie aean?ae?caoe??, caeeoe?a aaoa aaeaeoice, ui
aeeeeea? aeoeaaoe?th O-ee?oei oa iie?ii?oiiyaea?ieo eaeeioeeo?a
[Eaeaeaoaa ?.I.,1996; Eaeaeaoaa E.I., Eao?ooia A.A., Ieuaiei A.I.,1993].
O?c?ieia?/i? ?ioiio?iii? aeanoeaino? a?eo?ioeeoa?ieo iaia?ai
aecia/athoueny, aieiaiei /eiii, iayai?noth ia ?o iiaa?oi? ?aoeaioi??a
aiaeiaaiieo ?ioiiiiaeoeyoi??a, ni?aoe??th ?ioiiaeoeaieo ?a/iaei oa
noaiii iaia?aiieo aetheii?ioa?ae?a. Noai aetheii?ioa?ae?a iaia?ai —
u?eueii iia’ycaiee c nenoaiith aioeaai?a a?oi e?ia? [Ae?aiiee A.I.,
Aeecee A.I.,1990; AEeao?o A.A., Na?aa?yiay I.A., Eiiiaa A.E. e
ae?.,1997].

Aeooaeueiith i?iaeaiith no/anii? o?c?ieia?? ? aecia/aiiy iaoai?ci?a
noa??iiy i?aai?cio, a?eiaeo ci?i o?c?ieia?/ieo ooieoe?e, ui iiaea
iaaeaoe nooo?a? i?aeoe/i? ?aeiiaiaeaoe?? i?iaeiaaeaiiy aeeooy ethaeae
[*a?iooaiei E.O.,1997]. A?aeiii, ui ?ioiia nenoaia i?aeaea?oueny
ae?aaeaiei a?eiaei ci?iai [Oaie?i N., Aa?oii A.,1993], aea aiae?c
no/anii? e?oa?aoo?e iieacaa a?aenooi?noue a?aeiiinoae i?i a?- eia? ci?ie
i?ioean?a aca?iiae?? i?ae a?eo?ioeeoa?ieie iaia?aiaie oa eaeeioeeoaie ia
iniia? ci?i iiaa?oiaaeo aetheii?ioa?ae?a a?eo?ioeeo?a

CA’ssCIE ?IAIOE C IAOEIAEIE I?IA?AIAIE, IEAIAIE, OAIAIE. Aeaia
aeine?aeaeaiiy ? naiino?eiei o?aaiaioii eiieo?nii? oaie

AeEIO Oe?a?ie «Aea/aiiy aca?iiae?? a?eo?ioeeo?a oa iaeo?io?eueieo
eaeeioeeo?a a ?i?oe?aoe?? aioo??oiueinoaeeiiiai aaiie?co» iiia?
aea?ae?a?no?aoe?? 0193U034654, oeo? 01.03.00/041-93 oa aoei iieeaaeaii a
iniiao ieaiiai? iaoeiai-aeine?aeii? ?iaioe Oe?a?inueei? iaaee/ii?
noiiaoieia?/ii? aeaaeai?? «Aeaye? a?eia? iniaeeaino? aca?iiae??
a?eo?ioeeo?a oa eaeeioeeo?a», iiia? aea?ae?a?no?aoe?? 0196UO21065, oeo?
04/571, 96.03.06.

IAOA OA CAAAeAIIss AeINE?AeAEAIIss. Iaoith aeine?aeaeaiiy aoei
anoaiiaeaiiy a?eiaeo ci?i aetheii?ioa?ae?a a?eo?ioeeoa?ieo iaia?ai oa ?o
aieeao ia iieacieee ee?oeiiiai ?ioi?oaoo. O a?aeiia?aeiino? c iaoith
?iaioe aoee iinoaaeai? caaaeaiiy aeine?aeeoe o aeiii??a ??cieo a?eiaeo
a?oi (c o?aooaaiiyi a?oi e?ia?):

— noai ae?eii?ioa?aeiiai i?io?eth ?aoeaioi?iiai iiey iaia?ai
a?eo?ioeeo?a;

— noai iieaciee?a ?ioiii? nenoaie;

— ?ioiiiiaeoethth/? aoaeoe iaia?ai a?eo?ioeeo?a;

— ?ioiiiiaeoethth/? aoaeoe eiiiiiaio?a, ui ni?aiaai? ia iaia?aiao
a?eo?ioeeo?a.

IAOEIAA IIAECIA IO?EIAIEO ?ACOEUeOAO?A. Aia?oa aeyaeaia caeaaei?noue
?ioiiiiaeoethth/eo aeanoeainoae iaia?ai a?eo?ioeeo?a a?ae a?eo ethaeae.
Oae? ci?ie aeanoeainoae aecia/athoueny noaiii iaia?aiieo
aetheii?ioa?ae?a a?eo?ioeeo?a.

Aia?oa aeyaeaii, ui c a?eii ethaeeie ia iaia?aiao a?eo?ioeeo?a
ii/eiathoue ni?aoaaoeny ?a/iaeie, yeei i?eoaiaiia ?ioiiaeai?aneaia ae?y
oa caeaoi?noue ae?aioaaoe aoaeaaiaei? caeeoee iaia?ai.

Aia?oa aeyaeaii a?eia? iaae? ci?i iieaciee?a ?ioiii? nenoaie ethaeeie
i?e aca?iiae?? a?eo?ioeeo?a c eaeeioeeoaie; i?iaeaiiino?iaaii, ui
i?ioeane aca?iiae?? i?ae ee?oeiaie ?ioiii? nenoaie oa a?eo?ioeeoaie c
a?eii nooo?ai ci?iththoueny.

I?AEOE*IA Oe?II?NOUe IAeA?AEAIEO ?ACOEUeOAO?A. Aeiaaaeaii: oe? ci?ie
iieyaathoue a oiio, ui aca?iiae?y a?eo?ioeeoa?ieo iaia?ai c eaeeioeeoaie
c a?eii ci?ith?oueny oacii. Iaea?eueo ianoaa?eueiith oey aca?iiae?y
ianoa? a 46 — 52 ?iee oa noaa?e?co?oueny aei 60 ?ie?a. A?e 46 — 52 ?iee
? oaeoi?ii ?eceeo ?icaeoeo iaoieia??, ui iia’ycaia c ii?ooaiiyi ooieoe??
?ioiii? nenoaie. Iaea?eueo ae?aaeai? ci?ie o ethaeae, ye? iathoue a?oie
e?ia? A(II), A(III). Anoaiiaeaii: a?eo?ioeeoa?i? iaia?aie oa ?a/iaeie,
ui ni?aiaai? ia ?o iiaa?oi?, o ethaeae e?oiueiai a?eo i?iaeoothoue
?ioiinoi?aneai? aeanoeaino?, ui ia? a?aoeny aei oaaae i?ae /an
aaiio?ainooc?e.

Aaaeeea?noue iiaeaeueoiai aea/aiiy aca?iiae?? a?eo?ioeeo?a oa
eaeeioeeo?a, noaio a?eo?ioeeoa?ieo iaia?ai oa ni?aiaaieo ia ?? iiaa?oi?
eiiiiiaio?a, ui aieeaathoue ia ?ioiio nenoaio, iaaea? ciiao c’ynoaaoe
iaoai?ci iaoiaaiaco caoai?thaaiue, iia’ycaieo c ii?ooaiiyi no?oeoo?e
a?eo?ioeeoa?ieo iaia?ai, iiynieoe ci?ie ?ioiii? ?aaeoeaiino? i?aai?cio a
??ci? a?eia? ia??iaee.

?acoeueoaoe aeei?enoiaothoueny o iaa/aeueiiio i?ioean? eaoaae?
ii?iaeueii? o?c?ieia?? ethaeeie, ee?i?/ii? oa?iaeieia?? c eo?nii
ee?i?/ii? ?ioiieia??, i?e?ia?ieia??, a??onieia?? oa caaaeueii?
?ioiieia?? Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai??.

IIAENOEE AIANIE CAeIAOAA*A. Aaoi? ?ic?iaea i?ia?aio aeine?aeaeaiue,
iniaenoi aeeiiaa an? ?ioiieia?/i? oa aaiaoieia?/i? aeine?aeaeaiiy.
Aeena?oaio naiino?eii i?ia?a aiae?c onueiai io?eiaiiai oaeoe/iiai
iaoa??aeo. ?ic?iaea iniiaieo iieiaeaiue oa aeniiae?a ?iaioe oaeiae
iaeaaeeoue aeena?oaioo.

AI?IAAOe?ss ?ACOEUeOAO?A AeENA?OAOe??. Iniiai? iieiaeaiiy
aeena?oaoe?eii? ?iaioe iaaiai?thaaeenue ia I?aeaoc?anueeeo
iaoeiai-i?aeoe/ieo eiioa?aioe?yo «O?c?ieia?y ? iaoieia?y ia?aeeniiai
ieeneaiiy e?i?ae?a, aaiinoaco oa ?ioiiaaiaco» (1996, 1997, 1998 ?.,
Iieoaaa), I?aeia?iaei?e eiioa?aioe?? iieiaeeo a/aieo «O?c?ieia?y oa
iaoieia?y ia?aeeniiai ieeneaiiy e?i?ae?a aaiinoaco oa ?ioiiaaiaco
(Iieoaaa, 1997 ?.). ?iaioa i?ieoea ai?iaaoe?th ia can?aeaii? ?aaee
Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai?? (1998 ?.).

IOAE?EAOe??. ?acoeueoaoe aeena?oaoe?? iioae?eiaaii a 6 iaoeiaeo i?aoeyo,
1 c ieo — aac ni?aaaoi??a o aeaeaiiyo ?aeiiaiaeiaaieo AAE Oe?a?ie.

IANssA ?IAIOE. Aeena?oaoe?y aeeeaaeaia ia 121 noi??ioe? ae?oeiaaiiai
oaenoo oe?a?inueeith iiaith ? neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, ?icae?eo «Iaoa??aee oa iaoiaee aeine?aeaeaiue», aeanieo
aeine?aeaeaiue, ei?aeyoe?eiiai aiae?co oa iaaiai?aiiy io?eiaieo
?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaieo
e?oa?aoo?ieo aeaea?ae, ui i?noeoue 120 ?ia?o. Aeena?oaoe?y ?ethno?iaaia
1 iaethieii, 43 oaaeeoeyie oa 2 noaiaie.

IAOA??AEE ? IAOIAeE AeINE?AeAEAIIss

Aeey ae??oaiiy iinoaaeaieo caaaeaiue i?iaaaeaii ianoaaeaiiy 109 aeiii??a
/ieia?/i? ? ae?ii/i? noao? 4-o a?eiaeo a?oi c o?aooaaiiyi a?oi e?ia? ca
nenoaiith AA0. Ia?oa a?eiaa a?oia (18-24 ?iee, 25 /ie.) — ia??iae
caaa?oaiiy o?ce/iiai ?icaeoeo i?aai?cio, noaiiaeaiiy ?ioiieia?/iiai oa
ai?iiiaeueiiai noaoono. Ae?oaa a?eiaa a?oia (25-31 ??e, 27 /ie.) —
ia??iae noaoe?iia?iiai noaio, yeee a?aeiia?aea? iieiaeiio c??eiio
a?eia?. O?aoy a?eiaa a?oia (46-52 ?iee, 26 /ie.) — ia??iae noa?oiai
c??eiai a?eo, yeee oa?aeoa?eco?oueny ?aa?aneaieie ci?iaie a i?aai?ci?:
?iaiethoe?y oeiono, aeenai?iiiic, cieaeaiiy neioaco noaoaaeo ai?iii?a,
iathoue i?noea ci?ie iieaciee?a ?ioiii? nenoaie. *aoaa?oa a?eiaa a?oia
(60-70 ?ie?a, 31 /ie.) — ia??iae noaa?e?caoe?? aeeoo?caeaoiino?
i?aai?cio ia i?i?iaeueiiio ??ai? [Aeai?aoeeee E.E. 1998, Aaeuenaae/
A.E., Caii?iaeaiia A.A. 1987, O?eieiaa A.A. 1978, Eaeaeaoaa ?.I. oa ?io.
1996].

Ia’?eoaie aeine?aeaeaiue aoee e?ia, a?eo?ioeeoe oa ieacia e?ia?. O
ethaeae iaouana?oea i?iaiaeeee caa?? e?ia? ca aeiiiiiaith iaeii?aciaeo
ieanoeeiaeo oi?eoe?a c eoa?oaeueii? aaie a oeaio?eooaei? n?e?eiiiaai?
i?ia??ee c 3,8% ?ic/eio oeeo?aoo iao??th (ni?aa?aeiioaiiy 9:1).
Aeine?aeaeaiiy i?iaiaeeee ia noniaic?? eaeeioeeo?a (eiioe. 15,0o10 /e)
[Eino ?.A.,1978]. A?aeieo? a?eo?ioeeoe io?eioaaee o?e?aciaith
a?aeieaeith oeaio?eooaoaaiiyi ia i?ioyc? 20 oa. i?e 3000 ia/oa. Cae?aee
noia?iaoaioe i?ney ia?oi? oa o?aouei? a?aeieaie, a iiaeaeueoiio
noia?aoaioe 1 oa 3. Aei io?eiaii? noniaic?? eaeeioeeo?a a ??ai?e
e?eueeino? aeiaeaaaee o?c?ieia?/iee ?ic/ei iao??y oei?eaeo, a?aeieo?
a?eo?ioeeoe, noia?iaoaioe 1 oa 3 ? ?ieoaoaaee i?ioyaii 1 aiae. i?e
oaiia?aoo?? 37I N.

A i?iaao aecia/aee eiiieaen iieaciee?a noaiiioeyoe?e eaeeioeeo?a oa
o?c?ieia?/ii? aeoeaino? ee?oei e?ia? ethaeeie [Eaaaaeaa E.A., Iiiyeeia
E.Ae., 1990]. I?iaiaeeee i?ae?aooiie e?eueeino? eaeeioeeo?a a eaia??
Ai?y?aa oa eaeeioeeoa?ii? oi?ioee a caaa?aeaieo ca ?iiaiianueeei — A?ica
iaceao e?ia? [Eino ?.A.1978].

Iiaa?oiaa? ia?ea?e e?ioioeeo?a aecia/aee iai?yiei ?ioiioethi?anoeaioiei
iaoiaeii ca aeiiiiiaith iiiieeiiaeueieo aioeo?e aei iiaa?oiaaeo
aioeaai?a eaeeioeeo?a ethaeeie: NAe3 (O-ee?oeie), NAe4 (O-oaeia?e), NAe8
(O-noi?ani?e), NAe22 (A-ee?oeie) [Eeaon Aeae.,1990].

E?ioioeeoe aeae?eyee ?c aaia?ei?ciaaii? aaiicii? e?ia? oeaio?eooaoaaiiyi
ia a?aae??io? O?eie-Aa?ia?ao?io (aonoeia 1,077a/ie). 1-0,1 iei.
e?ioioeeo?a a ia’?i? 50 iee aiineee a oeaio?eooaei? i?ia??ee. Aei ee?oei
aeiaeaaaee 5 iee iiiieeiiaeueieo aioeo?e, ye? oanooaaee, oa ?ieoaoaaee
45 oa. i?e +4 N. Aei inaaeo a?aeieoeo ee?oei aeiaeaaaee 50 iee
F(ab)2-o?aaiaio?a aioeo?e a?aoe? aei ?ioiiaieiaoe?i?a ieo?, i?/aieo
O?OOe o ?ic/eiaii? 1:100. Ee?oeie c iaaooith oethi?enoeaioe??th
i?ae?aoiaoaaeeny ca aeiiiiiaith oethi?anoeaioiiai i?e?ineiio «Ethiai
?-8». E?euee?noue aioeaai-iiceoeaieo ee?oei i?ae?aoiaoaaee ye a?aenioie
oethi?anoeoth/eo ee?oei ia 200 e?ioioeeo?a ca aeiyoeii a?aenioeo
oethi?anoeoth/eo ee?oei, ui i?ae?aoiaoaaee a i?aia?ao? iaaaoeaiiai
eiio?ieth.

Ca aeiiiiiaith ae?aaiinoe/ieo iaai??a iie?eeii?a aioe-A, aioe-A oa
aioe-AA OII «Aaiaoieia», (?in?y, (OO9398-205-27575295- 94) aecia/aee
a?oie e?ia? ethaeeie nenoaie AA0.

Aecia/aiiy nooiaiy ci?ie ?aoeaioi?iiai i?io?eth iaia?ai a?eo?ioeeo?a
i?iaiaeeee ca iaoiaeeeith Eaeaeaoaaa ?.I. oa ni?aaao. (1995] oaeei
/eiii: iaae?aee 0,1 ie e?ia?, noaa?e?coaaee 0,05 ie 4,5 % ?ic/eiii
oeeo?aoa iao??th, o?e/? a?aeieaaee 0,15 I oei?eaeo iao??y,
oeaio?eooaoaaee 10 oa. i?e 300 g. 0,05 ie inaaeo a?eo?ioeeo?a
?anoniaiaeoaaee a 2 ie 0,15 I oei?eaeo iao??y.

A eiaeio eoieo noaiaea?oiiai ieaioaoo aeey ?ioiieia?/ieo ?aaeoe?e
(OO-64-2-278-79) aiineee ii 0,05 ie 0,15 I oei?eaeo iao??y. Eaeoeie a
e?eueeino? 1 ia ?ic/eiyee a 2 ie 0,15 I oei?eaeo iao??y (aiooaaee
aaniina?aaeiuei ia?aae aeei?enoaiiyi). Iio?i a ia?o? eoiee aa?oeeaeueieo
?yae?a aiineee ii 0,05 ie ?ic/eio a?aeiia?aeiiai eaeoeia. I?ney /iai
aeeiioaaee e?aoi? ?icaaaeaiiy, ia?aiiny/e 0,05 ie ai?noo 1-i? eoiee a
2-o eoieo ? o.ae.

Aiineee a eiaeio eoieo oanoe aa?oeeaeueieo ?yae?a 0,05 ie noniaic??
a?eo?ioeeo?a i?iae, ?ieoaoaaee i?e e?iiaoi?e oaiia?aoo?? 35-45 oa. Iae?e
aaethoeiaoe?? ioe?ithaaee a?coaeueii, ca o?ueioaaeueiith nenoaiith,
neeaaeath/e e?euee?noue aae?a aaethoeiaoe?? a eoieao eiaeiiai
aa?oeeaeueiiai ?yaeo. Iiaio aaethoeiaoe?th i?eeiaee ca 3 aaee,
aaethoeiaoe?th, i?e ye?e aaethoeiaoe iie?eaaee 2/3 eoiee — 2 aaee, yeui
aaethoeiaoe iie?eaaee 1/3 eoiee — 1 aae, a?aenooi?noue aaethoeiaoe?? — 0
aae?a. Oaeei /eiii, aae aaethoeiaoe?? i?yii i?iii?oe?eii a?aeia?aaea?
nooi?iue aaethoeiaoe?? a?eo?ioeeo?a, a /enei i?noeue ca’ycoaaiiy
eaeoei?a c ?aoeaioi?aie iaia?ai a?eo?ioeeo?a iaa?iaii i?iii?oe?eia aaeo
aaethoeiaoe?? [Eaeaeaoaa ?.I. oa ni?aaao.1995].

A ?iaio? aeei?enoaii iaa?? eaeoei?a: eaeoei ian?iiy eeinueei? eaanie?
(EIEE), eaeoei ian?iiy ni/aaeoe? (EIN), eaeoei ca?iaee?a ioaieoe? (ECI),
eaeoei aiaiaieea aiaa??ieenoiiai (EAA), eiieaiaaae?i A (Eii A), eaeoei
ei?e aoceie /i?ii? (EEA*), ye? ioiieththoue i?aeoe/ii aanue niaeo?
aoaeaaiaeieo caeeoe?a, ui cono??/athoueny ia a?ieia?/ieo iaia?aiao.

Iaoiaeii aeanoo?ainoi?iaoe?? e?ioioeeo?a aecia/aee caaaeueio
?ioiieia?/io ?aaeoeai?noue oa ooieoe?iiaeueio aeoeai?noue oaeia?ieo ?
noi?ani?ieo O-ee?oei. Aeine?aeaeaiiy oaeia?ii? oa noi?ani?ii? aeoeaiino?
O-e?ioioeeo?a i?iaiaeeee ia aeae?eaieo e?ioioeeoao (Ianoa?

A.O., Iico? A.E.,1989). Ooieoe?iiaeueia aeoeai?noue O-oaeia??a
aecia/aµoueny oaeia?iei aoaeoii (OA), a aeoeai?noue O-noi?ani??a —
a?aenioeii noi?an?? (AN), ui ae?aoiao?oueny ca oi?ioeaie: OA = 100 (b —
a)/b; AN = 100 (a — b)/b, aea; a — a?aenioie e?ioiaeano?a a eiio?ie?, b
— a?aenioie e?ioiaeano?a a aeine?ae?.

Io?eiaiee oeeo?iaee iaoa??ae aoa noaoenoe/ii ia?iaeaiee ia IAII IBM
PC/AT-286 «Omega». I?iaiaeeee ia/eneaiiy na?aaeiuei? a?eoiaoe/ii? (I),
na?aaeiueieaaae?aoe/iiai a?aeoeeaiiy (m), iiieeee na?aaeiuei?
a?eoiaoe/ii? (i), a??ia?aei?noue io?eiaieo ?acoeueoao?a ii eiao?oe??ioo
No’thaeaioa (t), eiao?oe??io?a ei?aeyoe?? i?ae ye?nieie iieacieeaie (r).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

Aaaeeeaith i?iaeaiith no/anii? o?c?ieia?? ? ?ice?eooy ooiaeaiaioaeueiiai
iaoai?cio noa??iiy i?aai?cio. Noa??iiy i?aai?cio iiaeia ?icaeyaeaoe ye
noa??iiy ie?aieo ee?oei aai ye i?ioeane noa??iiy i?aai?cio a oe?eiio.
Aecia/aiith oeeo aniaeo?a i?enay/aii aaeeeo e?euee?noue ?ia?o, aea
iiaii? yniino? o oeueiio ieoaii? iiee ui ia aeinyaiooi [*a?iooaiei
E.O.,1997; Oaie?i N.,1993; Aooaiei

A.I.,1997].

Iaei??th c aaaeeeaeo nenoai i?aai?cio, ui iaaoaa? ae?aaeaieo a?eiaeo
ci?i ? ?ioiia nenoaia. ?iaioaie A.I. Aooaiei [1993, 1998] iieacaii, ui o
a?eiaeo ci?iao aeoeaiino? e?ioioeeo?a aecia/ia ?ieue iaeaaeeoue
aioo??oiueioei?/i?e aeeoa?aioe?aoe?? O-e?ioioeeo?a o oeion?, yea
iia’ycaia c aeia?a a?aeiiith a?eiaith ?iaiethoe??th oeiono. A?eia? ci?ie
?ioiii? nenoaie a cia/i?e i??? iaoiiaeai? aieeaii i?e?iioi/aiiy
?ioiioeeo?a [Aooaiei A.I. oa ni?aao.,1997]. A oie aea /an ?niothoue
a?aeiiino? i?i a?eiao ci?io ?ioiiiiaeoethth/eo aeanoeainoae
a?eo?ioeeo?a, ye? ? iaeaeeae/ei ioi/aiiyi oee?eoethth/eo e?ioioeeo?a
[Eaeaeaoaa ?.I.,1996]. A ca’yceo c oeei, ie aea/eee noai
ae?eii?ioa?aeiiai i?io?eth ?aoeaioi?iiai iiey iaia?ai a?eo?ioeeo?a o
aeiii??a ??cieo a?eiaeo a?oi. Aeey oeueiai aoei aeei?enoaii
i?ea?iaeueiee iaoiaee/iee i?aeo?ae, a iniiao yeiai iieeaaeaii
aaethoeiaoe?th a?eo?ioeeo?a aoaeaaiaeniaoeeo?/ieie ae?eii?ioa?aeaie
(eaeoeiaie). Iaeii/anii, ie ioe?ithaaee iieacieee aaethoeiaoe??
a?aeieoeo a?eo?ioeeo?a, ui aeaei iiaeeea?noue ioe?ieoe ci?ie
aoaeaaiaeiiai i?io?eth ?aoeaioi?iiai iiey, ye? caeaaeaoue a?ae
ni?aiaaieo ia iaia?aiao ?a/iaei.

I?aeaeaaoe aiae?co io?eiai? ?acoeueoaoe, iiaeia c?iaeoe aeniiaee i?i
ci?io e?eueeino? aoaeaaiaeieo caeeoe?a a?eo?ioeeoa?ieo iaia?ai,
iia’ycaio c a?eii i?aai?cio. C a?eii a?eo?ioeeoe iinooiiai ca?eueoothoue
e?euee?noue i?noeue ca’ycoaaiiy c eaeoeiaie, ui iathoue ??cio
nii??aeiai?noue aei e?ioeaaeo caeeoe?a ae?eii?ioa?ae?a. Io?eiai? aeai?
ia?aaeaa/athoue, ui ?a/iaeie ni?aiaai? ia iaia?ai?, aeieothoue
ca’ycoaaiiy eaeoei?a c ae?eii?ioa?aeaie iaia?ai a?eo?ioeeo?a, ci?ithth/e
??aaiue aaethoeiaoe?? (oaae. 1).

Oaaeeoey 1.

A?eia? ci?ie aoaeaaiaeiiai i?io?eth ?aoeaioi?iiai iiey

iaia?ai a?eo?ioeeo?a a ii??aiyii? c ia?oith a?eiaith a?oiith

A?eia?.

A?oieA?oie

E?ia? A?aeieo? a?eo?ioeeoeIaa?aeieo? a?eo?ioeeoe 0 (I)
Neu-5AC-(2-6)Gal -25 — 31 ??eA (II)N-AC-D-Gal

a-L-Fuc N-AC-D-Gal

Neu-5AC-(2-6)- Gal A (III)—AA(IY)Neu 5AC-(2-6)Gal
-0 (I) Neu-5AC-(2-6)Gal -46 — 52 ?ieeA
(II)N-AC-D-GalN-AC Neu, N-AC-D-Glu

a-D-Man cA (III)a-L-Fuc
a-D-Man

N-AC-Neu, N-AC-D-Glu

Neu-5AC-(2-6)Gal AA(IY)—0 (I) a-L-Fuc

Neu-5AC-(2-6)Gal a-L-Fuc
60 — 70 ?ie?aA (II)a-L-Fuc

a-D-Man N-AC-Neu, N-AC-D-Glu

a-D-Man

Neu-5AC-(2-6)Gal

N-AC-D-Gal A (III)Neu-5AC-(2-6)Gal
a-D-Man AA(IY)a-D-Man

a-D-Fuc

Neu-5AC-(2-6)Gal a-D-Man
I?ei?oee: — cieaeaiiy /enea i?noeue ca’ycoaaiiy ?aoeaioi??a c
iaia?aiaie a?eo?ioeeo?a;

— ca?eueoaiiy /enea i?noeue ca’ycoaaiiy ?aoeaioi??a c iaia?aiaie
a?eo?ioeeo?a.

Oaeei /eiii, iaie aeyaeai? a?eia? ci?ie ?aoeaioi?iiai i?io?eth iaia?ai
a?eo?ioeeo?a, ye? ii/eiathoue ?icaeaaoeny a ia??iae 46 — 52 ?ie?a oa
noaa?e?cothoueny o oa?i?i 60 — 70 ?ie?a. Iaea?eueoa aeyaeaii ci?i o
in?a, ui iaeaaeaoue aei A(II) oa A(III) a?oi e?ia?, aea ia aei I(I) oa
AA(IY), ui iiaea aooe iia’ycaii c a?eiaei cieaeaiiyi niaoeeo?/iino?
??cii?iaiieo aaethoei?ia oa aaethoeiiaaio. E??i oiai, io?eiai? aeai?
ia?aaeaa/athoue a?eiao ci?io aoaeaaiaeieo eiiiiiaio?a, ui ni?aothoueny
ia a?eo?ioeeoao.

Ianooiieie aeine?aeaeaiiyie noaei c’ynoaaiiy a?eiaeo ci?i noaio ?ioiii?
nenoaie. Io?eiai? ?acoeueoaoe iieacothoue, ui iaea?eueoa a?eia? ci?ie
oi?eathoueny oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a oa ai?noo IgM; O-eaiea
nooo?ai ci?ithaaeanue eeoa a 4-e a?eia?e a?oi?. Caa?oa? ia naaa oaaao
oaci?noue ci?i iieaciee?a ?ioiii? nenoaie. Aecia/eeany
??ciini?yiiaai?noue ci?i oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a oa
iieaciee?a niaoeeo?/iiai ?ioi?oaoo (e?euee?noue A-?OE, 0-ee?oei oa
??aaiue IgM). A?eiaa cieaeaiiy /enea e?ioioeeo?a (a o./.O-ee?oei)
iaaiith i??ith eiiiaino?oueny c?inoaiiyi aianeo eiiiiiaio?a
ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio oa aoii?aeueiiai ?ioi?oaoo
(IgM).

A?aoiaoth/e io?eiai? aeai? oa aeai? e?oa?aoo?e [Eiceia A.A., 1988,1998;
Ea?aeueiee A.A.1992; Aaneeueaa A.I.1996], ie aeine?aeeee aieea
a?eo?ioeeo?a ia iniiai? iieacieee ee?oeiiiai ?ioi?oaoo. Aeey oeueiai aei
noniaic?? eaeeioeeo?a aeiaeaaaee a eiio?ieuei?e na??? iaa?aeieo?
a?eo?ioeeoe, a a aeine?aei? na??? o?e/? a?aeieo? a?eo?ioeeoe oeo naieo
in?a. I?ney ?ieoaaoe?? c a?eo?ioeeoaie aea/aee iieacieee ee?oeiiiai
?ioi?oaoo.

Ioaea, ie i?eeoee aei aeniiaeo, ui ca o?c?ieia?/ieo oiia iaia?aie
a?eo?ioeeo?a ia iathoue cia/iiai ?ioiiiiaeoethth/iai aieeao, aea a
oa?i?i 46-52 ?iee aiie ii/eiathoue a??ia?aeii aieeaaoe ia noai
iieaciee?a ?ioiii? nenoaie.

Ie aeine?aeeee ai?no noaiiioeyoe?? e?ioioeeo?a ca aeaieie aeni?an??
iiaa?oiaaeo iaia?aiieo ia?ea??a ND3, CD4, ND8, CD22 (O-ee?oeie,
O-oaeia?e, O-aoaeoi?e, A-ee?oeie, a?aeiia?aeii). ??aaiue aenia?n??
aeeoa?aioe?eieo iieaeoe ia e?ioioeeoao in?a 1-i? oa 3-i? a?eiaeo a?oi
iaeaea ia a?ae??ciyany, ca aeiyoeii ca?eueoaiiy ??aiy CD8 oa cieaeaiiy
??aiy CD22 o 3-e a?eia?e a?oi? (46-52?iee).

Oaeiae, iaie aoei ioe?iaii aieea iaoeaieo a?eo?ioeeo?a ia iieacieee
aeanoo?ainoi?iaoe?? e?ioioeeo?a, ia ianiaoeeo?/iee i?oiaai eiieaiaaae?i
A oa niaoeeo?/iee ooaa?eoe?i. Aeey oeueiai a eoeueoo?aeueia na?aaeiaeua
aiineee a?eo?ioeeoe aeiii??a 46-52 ?ie?a oa 18-24 ?ie?a. I?e oeueiio
a?eo?ioeeoe aeiaeaaaeeny aei e?ioioeeo?a 1-i? oa 3-i? a?eiaeo a?oi
aaoa?i- oa aiiio?iiii. Aianaiiy aei e?ioioeeo?a 1-i? a?eiai? a?oie
a?eo?ioeeo?a aeiii??a 3-i? a?eiai? a?oie (aaoa?io?iiii) aeaui
i?eai?/oaaee niiioaiio aeanoo?ainoi?iaoe?th, aea ni?eyee
i?oiaai?iaeoeiaai?e aeanoo?ainoi?iaoe??. Aianaiiy aei e?ioioeeo?a 3-i?
a?eiai? a?oie aiaeia?/ieo a?eo?ioeeo?a (aiiio?iiii) nooo?ai ia aieeaaei
ia iieacieee niiioaiii? oa i?aeneethaaei i?oiaai?iaeoeiaaio
aeanoo?ainoi?iaoe?th. A?eo?ioeeoe 1-i? a?eiai? a?oie iacia/ii
i?aeaeuoaaee oaeia?iee aoaeo, a 3-i? — eiai ??cei cieaeoaaee. A?aenioie
noi?an?? i?ae ae??th a?eo?ioeeo?a a iaio a?eiaeo a?oiao i?aeaeuoaaany,
iniaeeai a 3-?e a?eia?e a?oi?.

C aeaieo e?oa?aoo?e a?aeiii, ui ?aaeoe?y e?ioioeeo?a ia ianiaoeeo?/io
noeioeyoe?th i?oiaaiaie iiaea a?ae??ciyoeny a?ae ?aaeoe?? ia niaoeeo?/i?
noeioee [*a?iooaiei E.O., 1997]. Oiio ie aeine?aeeee aieea a?eo?ioeeo?a
ia aeanoo?ainoi?iaoe?th e?ioioeeo?a i?ae ae??th niaoeeo?/iiai noeioeo —
ooaa?eoe?io. I?e noeioethaaii? ooaa?eoe?iii a?eo?ioeeoe iaio a?eiaeo
a?oi aeyaeyee noeioethth/o ae?th, yea a?ae??ciyeany aaoa?io?iii?noth.

A ianooii?e na??? aeine?ae?a ie aeine?aeeee ?ioiiiiaeoethth/o ae?th
?a/iaei, ui ni?aothoueny ia iaia?aiao a?eo?ioeeo?a, ia noai ee?oeiiiai
?ioi?oaoo a caeaaeiino? a?ae a?eo i?aai?cio. Aeey oeueiai aei
eaeeioeeoa?ii? noniaic?? aeiaeaaaee o?c?ieia?/iee ?ic/ei, noia?iaoaioe 1
oa 3. sse iieacaee aeine?aeaeaiiy, ia iaia?aiao a?eo?ioeeo?a ethaeae
a?eii 18-31 ?ie?a ni?aothoueny eiiiiiaioe, ye? ia iathoue nooo?ai?
?ioiio?iiii? ae??. O a?oe? 46-52 ?iee ia a?eo?ioeeoao ii/eiathoue
ni?aoaaoeny ?a/iaeie caeaoi? i?aeaeuoaaoe aaeaaceai? aeanoeaino?
iaeo?io?e?a oa /enei oaio?e?i/ooeeaeo A-?OE. O a?oe? 60-70 ?ie?a
a?eo?ioeeoe ni?aothoue ?a/iaeie, ye? iathoue ?ioiinoi?aneaiee aieea,
cieaeothoue /enei A-?OE oa I-?OE.

Aeyaeaia ci?ia iieaciee?a ee?oeiiiai ?ioi?oaoo i?ae ae??th
a?eo?ioeeoa?ieo iaia?ai oa ni?aiaaieo ia ieo ?a/iaei. Oea aeyaeei
iaiao?aei?noue i?iaaaeaiiy ei?aeyoe?eiiai aiae?co aca?iiae?? oa ca’yceo
i?ae noaiii a?eo?ioeeoa?ieo iaia?ai oa aeanoeainoyie ni?aiaaieo ia ieo
?a/iaei. Aeey ocaaaeueiaiiy a?eiaeo ci?i ca’yceo ?ioiio?iiii? ae??
iaia?ai a?eo?ioeeo?a oa ?a/iaei, ui ni?aiaai? ia ieo, ie aeae?eeee o?e
iniiai? iieacieee A-?OE, A-?OI, I-?OE oa aeei?enoaee aeaiaioe
eeanoa?iiai aiae?co. Io?eiai? ?acoeueoaoe iieacaee, ui iniiaiei
iieacieeii, yeee aecia/a? oi?ioaaiiy eeanoa??a ? I-?OE. Oaeei /eiii, c
a?eii ii?ooo?oueny ia?aaaaeii eiia?iiaaiee aieea iaia?ai a?eo?ioeeo?a oa
ni?aiaaieo ia ieo ?a/iaei ia noai I-?OE.

Ie aenoioee i?eiouaiiy i?i oa, ui ci?ia ?ioiiiiaeoethth/iai aieeao
iaia?ai a?eo?ioeeo?a c a?eii iiaea aooe iia’ycaia c noaiii iaia?aiieo
ae?eii?ioa?ae?a (oaae. 2).

Oaeei /eiii, ?ioiiiiaeoethth/a ae?y iaia?ai a?eo?ioeeo?a iia’ycaia ?c
noaiii ae?eii?ioa?ae?a ?o iaia?ai. Iayai? ?acoeueoaoe i?aeoaa?aeaeothoue
i?eiouaiiy [Eaeaeaoaa ?.I.,1996; Eiceia A.A.,1998] i?i i?e?iaeo
?ioiiiiaeoethth/eo aeanoeainoae iaia?ai a?eo?ioeeo?a.

0.9

Oaaeeoey 2.

A?eia? ci?ie ei?aeyoe?eieo ca’yce?a i?ae ?ioiio?iiiith ae??th

iaia?ai a?eo?ioeeo?a oa noaiii ?o iiaa?oiaaeo ae?eii?ioa?ae?a (p< 0,05) A?eiaa A?oiaEi?aeyoe?eia ia?aCiae eiao. ei?aeyoe?? Aoaeaaiaeiee neeaae aeaoa?i?iaio 1 (18-24 ?.)A-?OE / ECI A-?OE / EAA( + ) ( + )N-Ac-Neu-D-Glu a-L-Fuc 2 (25-31 ?.)O-o / EIN O-o / EEA*( - ) ( - )a-D-Man Neu-5Ac-(2-6)Gal 3 (46-52 ?.)-- - 4 (60-70 ?.)A-?OE / Eii A O-o / EIN O-o / Eii A O-n / EEA*( + ) ( + ) ( + ) ( - )a-D-Man a-D-Man a-D-Man Neu-5Ac-(2-6)Gal Aeey ia?aa??ee oeueiai i?eiouaiiy, ie i?iaaee ei?aeyoe?eiee aiae?c aeine?aeaeaiiy ca'yceo ?ioiio?iiieo aeanoeainoae ?a/iaei, ui ni?aothoueny ia iaia?aiao c? ci?iaie aoaeaaiaeieo aeaoa?i?iaio iaia?ai a?eo?ioeeo?a (oaae. 3). Oaaeeoey 3. A?eia? ci?ie ei?aeyoe?eieo ca'yce?a i?ae ?ioiio?iiiith ae?µth ?a/iaei, ni?aiaaieo ia iaia?ai?, ?c ci?iaie aoaeaaiaeieo aeaoa?i?iaio iaia?ai a?eo?ioeeo?a (p< 0,05) A?eiaa A?oiaEi?aeyoe?eia ia?a Ciae eiao. Ei?aeyoe??Aoaeaaiaeiee neeaae aeaoa?i?iaio 1 (18-24 ?.)On / EAA On / EEA* I-?OE / Eii A( + ) ( + ) ( - )a-L-Fuc Neu-5Ac-(2-6)Gal a-D-Man 2 (25-31 ?.)- -3 (46-52 ?.)A-?OI /EAA ( + )a- L-Fuc 4 (60-70 ?.)A-?OE / Eii A A-?OE / EEA* E-?OI / EIN T-?OI / ECI O-n / EEA* I-?OE / EAA ( - ) ( - ) ( - ) ( - ) ( + ) ( + )a-D-Man Neu-5Ac-(2-6)Gal a-D-Man N-Ac-Neu N-Ac-D-Gl Neu-5Ac-(2-6)Gal a-L-Fuc Aeyaeee ?nioaaiiy ca'yce?a i?ae ?ioiio?iiiith aeoeai?noth ?a/iaei, ui ni?aiaai? ia iaia?ai? a?eo?ioeeo?a oa niaeo?ii aoaeaaiaeieo aeaoa?i?iaio ia iaia?aiao a?eo?ioeeo?a. Nooo?ai, ui c a?eii c?inoa? ci?ia aoaeaaiaeieo aeaoa?i?iaio ye ia iaia?aiao a?eo?ioeeo?a, oae ? ?ioiiiiaeoethth/a ae?y ?a/iaei, ui ni?aiaai? ia ieo. Oaeei /eiii, noai ae?eii?ioa?aeiiai i?io?eth ?aoeaioi?iiai iiey iaia?ai a?eo?ioeeo?a o aeiii??a ??cieo a?eiaeo a?oi na?ae/eoue, ui iaea?eueo nooo?a? a?aei?iiino? niinoa??aaeeny a ae?eii?ioa?aeiiio i?io?e? iaa?aeieoeo a?eo?ioeeo?a, ye? i?ney ia?oi? a?aeieaee iinooiiai ciaiooaaeeny, a i?ney o?aouei? - noaaaee i?i?iaeueieie. Oaeei /eiii, ae?eii?ioa?aeiee i?io?eue iaia?ai ci?ith?oueny ca ?aooiie ?a/iaei, ui ooai?ththoueny a i?aai?ci? a i?ioean? noa??iiy. A?eia? ci?ie iaeae?aci?oa oi?eaeeny a?eo?ioeeo?a A(II) oa A(III) a?oi e?ia?. Iaea?eueo ?acenoaioieie aei a?eiaeo ci?i aeyaeeenue a?eo?ioeeoe AA(IY) a?oie e?ia?. Ia?aeaeueii oeei ci?iai, niinoa??aaee ci?ie iieaciee?a ee?oeiiiai ?ioi?oaoo. Iaenooo?a?o? ci?ie oi?eaeeny oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a oa ai?noo ?ioiiaeiaoe?i?a. Noai O-eaiee ?ioi?oaoo nooo?ai ci?ithaaany o ethaeae a?eii 60-70 ?ie?a. Caa?oa? ia naaa oaaao oaci?noue ci?i ?ioi?oaoo oa, aei iaaii? i??e, eiiiainaoe?y a?eiaiai cieaeaiiy /enea e?ioioeeo?a ? O-ee?oei aiane?aeie aeoeaaoe?? ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio oa aoii?aeueiiai ?ioi?oaoo. ?ioiiiiaeoethth/a ae?y iaia?ai a?eo?ioeeo?a ethaeae iieiaeiai a?eo i?iyaey?oueny a iii??i?e aeoeaoth/?e ae??, aea, ii/eiath/e c 46-52 ?ie?a, a?eo?ioeeoe a?eueo ae?acii aieeaathoue ia noai ?ioiii? nenoaie oa ia?aeaeueii ci?iththoue naith aeoeai?noue. Noooµai, ui ?ioiiiiaeoethth/a ae?y a?eo?ioeeoa?ieo iaia?ai iaea?eueo ae?acii i?iyaeyeany a aaoa?io?iiieo aeine?aeao, oiaoi, eiee aei eaeeioeeoa?ii? iane iieiaeeo in?a aeiaeaaaee a?eo?ioeeoe ethaeae iioeeiai a?eo oa iaaiaee. Ioaea, oe? aeai? aeaiiino?othoue o?c?ieia?/io caaeainiaai?noue i?ae noaiii ?ioiii? nenoaie oa ?ioiiiiaeoethth/ith ae??th a?eo?ioeeo?a a i?ioean? noa??iiy. A?eo?ioeeoa?i? iaia?aie oa ?a/iaeie, ui ni?aiaai? ia ieo, a iieiaeiio a?oe? iathoue iiae?aiee aieea ia iieacieee o?c?ieia?/ii? ?ioiii? nenoaie. C a?eii ii/eiathoue aeyaeyoeny ?ica?aeiino? a ?o ae?? ia aeni?an?th ?aoeaioi??a O-ee?oei oa aaeaaceai? aeanoeaino? iaeo?io?e?a. Aeyaeaii, ui c a?eii ii?ooo?oueny ia?aaaaeii eiia?iiaaiee aieea iaia?ai a?eo?ioeeo?a oa ?a/iaei, ui ni?aiaai? ia ieo, ia noai A-ee?oei. Aiane?aeie i?iaaaeaiiy ei?aeyoe?eiiai aiae?co anoaiiaeaii, ui ?ioiiiiaeoethth/a ae?y iaia?ai a?eo?ioeeo?a oa ?? a?eia? ci?ie iia'ycai? ?c noaiii ae?eii?ioa?ae?a ?o iaia?ai. Oae naii, c a?eii ci?ithµoueny ? aoaeaaiaeiee neeaae ?a/iaei, ui ni?aothoueny ia iaia?aiao a?eo?ioeeo?a. Oaea ci?ia aeeeeea? ii?ooaiiy ?ioiiiiaeoethth/eo aeanoeainoae ni?aiaaieo a?eo?ioeeoaie ?a/iaei. Aaaeeeaei oaeoii ? oa, ui c a?eii c?inoa? ci?ia aoaeaaiaeieo aeaoa?i?iaio ye ia a?eo?ioeeoa?ieo iaia?aiao, oae ? a neeaae? ?a/iaei, ui ni?aiaai? ieie. Aeyaeeinue, ui iaea?eueo /ooeeaeie aei a?eiaeo ci?i ?ioiiiiaeoethth/i? ae?? iaia?ai a?eo?ioeeo?a oa ?a/iaei, ui ni?aiaai? ia ieo, ? iniae c A(II) oa A(III) a?oiaie e?ia?. Iaea?eueo ianoaa?euei? oe? iieacieee a in?a 46-52 ?ie?a. A E N I I A E E. 1. Ae?eii?ioa?aeiee i?io?eue iaia?ai a?eoe?ioeeo?a c a?eii /?oei ci?ith?oueny o a?aeiia?aeiino? aei a?oie e?ia? ca nenoaiith AAI, iaea?eueo? ci?ie oi?eathoueny caeeoe?a a-L-Fuc, a-D-Man oa Neu-5Ac-(2-6)Gal. 2. C a?eii a?aeaoaathoueny oaci? ci?ie iieaciee?a ?ioi?oaoo, ye? ia?aaaaeii oi?eathoueny oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a oa ai?noo IgM. Noai O-eaiee nooo?ai ci?ith?oueny eeoa o in?a a?eii 60 -70 ?ie?a. 3. ?ioiiiiaeoethth/a ae?y iaia?ai a?eo?ioeeo?a in?a a?eii 18-31 ?ieo i?iyaey?oueny i?aeaeuaiiyi a?aenioeo A-?OE, a ia??iae 46-52 ?ie?a - aeoeaaoe??th aaeaaceaii? caeaoiino? iaeo?io?e?a oa i?aeaeuaiiyi a?aenioeo oaio?e?i-/ooeeaeo A-?OE, a a ia??iae 60-70 ?ie?a - aeoeaaoe??th aaeaaceaii? caeaoiino? iaeo?io?e?a oa cieaeaiiyi a?aenioeo I-?OE. 4. Iaia?aie a?eo?ioeeo?a in?a a?eii 18-31 ?ieo iathoue ?ioiinoi?aneaio ae?th, a a?eo?ioeeoe in?a 46-52 ?ie?a iaaiaee - ?ioiinoeioethth/ee aieea (ca aeaieie ?aaeoe?? aeanoo?ainoi?iaoe??, noeioeueiaaii? ianiaoeeo?/iei /eiieeii - Eii A). I?e noeioeyoe?? e?ioioeeo?a ooaa?eoe?iii a?eo?ioeeoe iaio a?eiaeo a?oi aaoa?io?iiii i?aeneeththoue aeanoo?ainoi?iaoe?th. 5. O in?a a?eii 46-52 ?ie?a ia a?eo?ioeeoa?ieo iaia?aiao ii/eiathoue ni?aoaaoeny ?a/iaeie, ye? i?aeaeuothoue aaeaaceai? aeanoeaino? iaeo?io?e?a oa /enei oaio?e?i-/ooeeaeo A-?OE, a 60-70 ?ie?a - ?a/iaeie, ye? iathoue ?ioiinoi?aneaiee aieea, cieaeothoue /enei I- oa A-?OE. C a?eii ii?ooo?oueny ia?aaaaeii eiia?iiaaiee aieea iaia?ai a?eo?ioeeo?a oa ?a/iaei, ui ni?aiaai? ia ieo, ia noai I-?OE. Iaea?eueoa ianoaa?euei?noue iieaciee?a, ui aea/aeeny, aeyaey?oueny a in?a a?eii 46-52 ?iee. 6. ?ioiiiiaeoethth/a ae?y iaia?ai a?eo?ioeeo?a iia'ycaia ?c noaiii ae?eii?ioa?ae?a ?o iaia?ai. A in?a a?eii 18-24 ?iee ?ioiiiiaeoethth/a ae?y aecia/a?oueny caeeoeaie a-L-Fuc oa N-Ac-Neu-D-Glu, a 25-31 ??e - a-D-Man oa Neu-5Ac-(2-6)Gal, a 60-70 ?ie?a - ia?aaaaeii a-D-Man. Iaeae?aci?o? a?eia? ci?ie aoaeaaiaeiiai i?io?eth oa ?ioiiiiaeoethth/i? ae?? oi?eathoueny a?eo?ioeeo?a in?a c A(II) oa A(III) a?oiaie e?ia?. 7. ?ioiiiiaeoethth/a ae?y ?a/iaei, ui ni?aothoueny ia iaia?aiao a?eo?ioeeo?a, oaeiae iia'ycaia c ?o aoaeaaiaeiei niaeo?ii oa caeaoi?noth aeieoaaoe iaia?aii? caeeoee aoaeaaiae?a. A a?oe? 18-24 ?ie?a ?o ae?y iia'ycaia c caeeoeaie a-L-Fuc, a-D-Man oa Neu-5Ac-(2-6)Gal, a 46-52 ?iee - a-L-Fuc, a a 60-70 ?ie?a - a-D-Man, Neu-5-Ac-(2-6)Gal, N-Ac-Neu, N-Ac-DGlu. NIENIE ?IA?O,IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??: 1.Aa?eaei E.A., Eaeaeaoaa E.I. ?ieue y?eo?ioeeoa?iuo iaia?ai a ?acaeoee aic?anoiuo eciaiaiee iieacaoaeae eeaoi/iiai eiioieoaoa//I?iaeaie aeieia?? oa iaaeeoeeie. -1997. -1-2. N.73-76. 2.Aa?eaei E.A., Eaeaeaoaa E.I. Aic?anoiua eciaiaiey aeeeii?ioaeaeiiai i?ioeey ?aoeaioi?iiai iiey iaia?ai y?eo?ioeeoia//I?iaeaiu noa?aiey e aeieaieaoey. -1998. -o.7, N1. -N.3-7. 3.Aa?eaei E.A., Aaeei I.A., Aaooiaaiei I.A., Aia?iaa I.A. Aeeyiea aic?anoiuo eciaiaiee iaia?ai y?eo?ioeeoia ia iaeioi?ua iieacaoaee eeaoi/iiai eiioieoaoa//I?iaeaie aeieia?? oa iaaeeoeeie. -1998. o.2, N5-6. -N.55-58. 4.Aa?eaei E.A. Eciaiaiea ?aoeaioi?iiai i?ioeey y?eo?ioeeoia i?e iaeioi?uo aooieiioiiuo caaieaaaieyo//Aeooaeuei? ieoaiiy oai?aoe/ii? oa ee?i?/ii? iaaeeoeeie ia no/aniiio ??ai?. - Iieoaaa. -1996. -N.32. 5.I.A.Aaeei, I.A.Aaooiaaiei,E.I.Cayaieueneay, Y.E.Eaeaeaoaaa, I.A.Eaae, E.A.Aa?eaei. Ei??eae?othuaa aeaenoaea neioaoe/aneeo iaioeaeia-aiaeiaia anoanoaaiiiai iaioeaeiiai eiiieaena ii/ae ia ninoiyiea i?aaiecia e?un i?e aooieiioiiii iao?eoa//I?iaeaie aeieia?? oa iaaeeoeeie.-1999.-? 1-2.-N.120-124. 6.Ieuaiei I.I.,A?eoeae I.I., Eeoaei A.A., Aa?eaei E.A., Aiiaea?/oe A.A., Ioee ?.I. Ai?iiiaeueiue noaoon e ea?eioeie?iaaiea o?iiinii o eeoe, o/anoaiaaaoeo a eeeaeaeaoeee iineaaenoaee *AYN//Ananithciay eiioa?aioeey "?aaeeiaeieiae/aneea iineaaenoaey aaa?ee ia *AYN". - Ieine. -1991. -N.23-26. Aiioaoe?y Aa?eaei E.A. A?eia? iniaeeaino? aca?iiae?? a?eo?ioeeo?a oa eaeeioeeo?a e?ia? ethaeeie. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 03.00.13 - o?c?ieia?y ethaeeie oa oaa?ei. - Oe?a?inueea aeaaeai?y aa?a?ieo iaoe, ?inoeooo naeia?noaa OAAI, Iieoaaa, 1999. A ?iaio? iaaeai? aenia?eiaioaeuei? aeine?aeaeaiiy anoaiiaeaiiy a?eiaeo ci?i ae?eii?ioa?ae?a a?eo?ioeeoa?ieo iaia?ai oa ?o aieeao ia iieacieee ee?oeiiiai ?ioi?oaoo. Aeyaeai? ci?ie ?ioiiiiaeoethth/eo aeanoeainoae iaia?ai a?eo?ioeeo?a oa ni?aiaaieo ia ieo ?a/iaei a caeaaeiino? a?ae a?eo ethaeae. Aeine?aeaeai? a?eia? iaae? ci?i iieaciee?a ?ioiii? nenoaie ethaeeie i?e aca?iiae?? a?eo?ioeeo?a c eaeeioeeoaie, ye? c a?eii nooo?ai ci?iththoueny. Iaea?eueo ianoaa?eueiith oey aca?iiae?y noa? a 46-52 ?iee ? yaey? niaith oaeoi? ?eceeo ?icaeoeo iaoieia??, ui iia'ycaia c ii?ooaiiyi ooieoe?? ?ioiii? nenoaie. Iaea?eueo ae?aaeai? ci?ie a ethaeae, ye? iathoue a?oie e?ia? A(II), A(III). Anoaiiaeaii, ui a?eo?ioeeoa?i? iaia?aie oa ?a/iaeie, ui ni?aiaai? ia ?o iiaa?oi?, o ethaeae e?oiueiai a?eo iathoue ?ioiinoi?aneai? aeanoeaino?, ui ia? a?aoeny aei oaaae i?ae /an aaiio?ainooc?e. Aeine?aeaeaiiy aca?iiae?? a?eo?ioeeo?a oa eaeeioeeo?a, noaio a?eo?ioeeoa?ieo iaia?ai oa ni?aiaaieo ia ?o iiaa?oi? eiiiiiaio?a, ui aieeaathoue ia ?ioiio nenoaio, iaaea? ciiao c'ynoaaoe iaoai?ci iaoiaaiaco caoai?thaaiue, iia'ycaieo c ii?ooaiiyi no?oeoo?e a?eo?ioeeoa?ieo iaia?ai, iiynieoe ci?ie ?ioiii? ?aaeoeaiino? i?aai?cio a ??ci? a?eia? ia??iaee. Eeth/ia? neiaa: a?eo?ioeeoe, eaeeioeeoe, a?eia? ci?ie, ae?eii?ioa?aee, iaia?aie a?eo?ioeeo?a. Aiiioaoeey Aa?eaei E.A. Aic?anoiua iniaaiiinoe acaeiiaeaenoaey y?eo?ioeeoia e eaeeioeeoia e?iae /aeiaaea. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 03.00.13 - oeceieiaey /aeiaaea e aeeaioiuo. - Oe?aeineay aeaaeaiey aa?a?iuo iaoe, Einoeooo naeiiaiaenoaa OAAI, Iieoaaa, 1999. A ?aaioa i?aaenoaaeaiu yenia?eiaioaeueiua enneaaeiaaiey aic?anoiuo eciaiaiee aeeeii?ioaeaeia y?eo?ioeeoa?iuo iaia?ai e eo aeeyiea ia iieacaoaee eeaoi/iiai eiioieoaoa. Enneaaeiaaia eiioiiiiaeoee?othuay niiniaiinoue iaia?ai y?eo?ioeeoia e ni?ae?iaaiiuo ia ieo aauanoa a caaeneiinoe io aic?anoa ethaeae. Iaeaieaa nouanoaaiiua eciaiaiey iaaethaeaeenue a aeeeii?ioaeaeiii i?ioeea iaioiuouo y?eo?ioeeoia, ii iinea ia?aie ioiuaee iie iinoaiaiii oiaiueoaeenue, a iinea o?aoueae - noaiiaeeenue ieieiaeueiuie. Yoi naeaeaoaeuenoaoao i oii, /oi aeeeii?ioaeaeiue i?ioeeue iaia?ai y?eo?ioeeoia eciaiyaony ca n/ao aauanoa, eioi?ua ia?aciaaeenue a i?aaiecia a i?ioeanna noa?aiey. Iaeaieaa au?aaeaiiua aic?anoiua eciaiaiey eanaeenue y?eo?ioeeoia A(II) e A(III) a?oii e?iae. ?acenoaioiuie ii ioiioaieth e aic?anoiui eciaiaieyi auee y?eo?ioeeou AA(IY) a?oiiu e?iae. Auyaeaiu aic?anoiua a?aieoeu eciaiaiee iieacaoaeae eiioiiie nenoaiu /aeiaaea i?e acaeiiaeaenoaee y?eo?ioeeoia n eaeeioeeoaie, eioi?ua n aic?anoii nouanoaaiii eciaiythony. Iaeaieaa ianoaaeeueiui yoi acaeiiaeaenoaea noaiiaeony a aic?anoa 46-52 eao e yaeyaony oaeoi?ii ?enea ?acaeoey iaoieiaee, naycaiiie n ia?ooaieyie ooieoeee eiioiiie nenoaiu. Onoaiiaeaii, /oi y?eo?ioeeoa?iua iaia?aiu e aauanoaa, ni?ae?iaaiiua ia eo iiaa?oiinoe, o ethaeae iiaeeeiai aic?anoa iaeaaeatho eiioiinoi?anneaiuie naienoaaie e ia yoi iaiaoiaeeii ia?auaoue aieiaiea ai a?aiy aaiio?ainoocee. Ia?aeeaeueii yoei eciaiaieyi iaaethaeaeenue eciaiaiey iieacaoaeae eeaoi/iiai eiioieoaoa. Aieaa au?aaeaii yoi eanaeinue oaaioeeoa?iie aeoeaiinoe iaeo?ioeeia e niaea?aeaiey eiioiiaeiaoeeiia. Ninoiyiea O-caaia nouanoaaiii eciaiyeinue a 60-70 eao. Iaaethaeaeanue aic?anoiay oaciinoue eciaiaiee eiioieoaoa e iaeioi?ay eiiiainaoeey aic?anoiiai nieaeaiey /enea eeioioeeoia e O-eeaoie aneaaenoaea aeoeaaoeee ianiaoeeoe/aneie ?acenoaioiinoe i?aaiecia e aoii?aeueiiai eiioieoaoa. Eiioiiiiaeoee?othuaa aeaenoaea iaia?ai y?eo?ioeeoia a iieiaeii aic?anoa iaeaaeaei oia?aiiie aeoeaiinoueth, ii ia/eiay n 46-52 eao, i?eia?aoaei io/aoeeaia aeeyiea ia ninoiyiea eiioiiie nenoaiu e ia?aeeaeueii eciaiyei naith aeoeaiinoue. Iaeaieaa au?aceoaeueii eiioiiiiaeoee?othuaa aeaenoaea y?eo?ioeeoa?iuo iaia?ai i?iyaeyeinue a aaoa?io?iiiuo enneaaeiaaieyo, o. a. eiaaea e eaeeioeeoa?iie acaane iieiaeeo eeoe aeiaaaeyee y?eo?ioeeou ethaeae iiaeeeiai aic?anoa e iaiai?io. Yoe aeaiiua aeaiiino?e?otho oeceieiae/aneoth naaeaine?iaaiinoue iaaeaeo ninoiyieai eiioiiie nenoaiu e eiioiiiiaeoee?othuei aeaenoaeai y?eo?ioeeoia a i?ioeanna noa?aiey. Y?eo?ioeeoa?iua iaia?aiu e aauanoaa, ni?ae?iaaiiua ia ieo, a iieiaeii aic?anoa ia aeeytho ia iieacaoaee oeceieiae/aneie eiioiie nenoaiu. N aic?anoii iiyaeythony ioee/ey a eo aeaenoaee ia yeni?anneth ?aoeaioi?ia O-eeaoie e aaeaaceaiua naienoaa iaeo?ioeeia, iaaethaeaaony i?aeiouanoaaiii eiiaeie?iaaiiia aeeyiea iaia?ai y?eo?ioeeoia e aauanoa, ni?ae?iaaiiuo ia ieo, ia ninoiyiea A-eeaoie. Aeieacaii, /oi eiioiiiiaeoee?othuaa aeaenoaea iaia?ai y?eo?ioeeoia e aic?anoiua eciaiaiey naycaiu n ninoiyieai aeeeii?ioaeaeia eo iaia?ai. Oae aea, n aic?anoii eciaiyaony oaeaaiaeiue ninoaa aauanoa, ni?ae?oaiuo iaia?aiaie y?eo?ioeeoia, /oi aaaeao e ia?ooaieyi eiioiiiiaeoee?othueo naienoa y?eo?ioeeoia. Aaaeiui oaeoii yaeyaony oi, /oi n aic?anoii i?ienoiaeyo eciaiaiey oaeaaiaeiuo aeaoa?ieiaio eae ia y?eo?ioeeoa?iuo iaia?aiao, oae e a ninoaaa aauanoa, ni?ae?iaaiiuo eie. Eeth/aaua neiaa: y?eo?ioeeou, eaeeioeeou, aic?anoiua eciaiaiey, aeeeii?ioaeaeu, iaia?aiu y?eo?ioeeoia. The summary Berkalo L.V. "Age features of interaction between human erythrocytes and leukocytes ". Manuscript. The dissertation on competition of a scientific degree of the Candidate of Biological sciences on a speciality 03.00.13 - Human and Animals Phisiology.- Ukrainian academy of agrarian sciences, Poltava Research Institute for pig-breeding. - Poltava, 1999. In work the experimental data on an establishment of age changes glycoproteids erythrocytes of membranes and their influence on parameters cells of immunity are given. The revealed changes of immune properties of membranes erythrocytes and substances sorbed on them depending on age of the people. The investigated age borders of changes of immune parameters of the man at interaction erythrocytes with leukocytes, which with age essentially change. Most astable this interaction becomes at 46-52 years and represents the factor of risk of pathology development which is connected to infringement of immune system function. The most expressed changes was found at the people, which have groups of blood A(II), B(III) that erythrocyte membranes and substances which sorbed on their surface, at the people of mature age have immunosupressive property, which should be considered in time hemotransfusion. The research of interaction between erythrocytes and leukocytes, influences on immunity system. This is an additional mechanism of pathogenesis of diseases connected to infringement of the structure of erythrocyte membranes, to explain the changes of immune reactions in the carved age periods. Key words: erythrocytes, leukocytes, age peculiarities, glycoproteids, erythrocytes membranes.

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