OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

A?EIUe Aeaaeeneaa Einoyioeiiae/

OAeE 616.72-002-06:616.12

IAOIEIA?ss NA?Oess I?E CAIAEUeIEO

CAOAI?THAAIIssO NOAEIA?A (?ICIIANTHAeAEAI?NOUe, Ae?AAIINOEEA,

IAOIAAIAC, E?EOAAIIss)

14.01.11 – ea?ae?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I.Ai?ueeiai IIC Oe?a?ie

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, i?ioani? Neiy/aiei Ieaa Aieiaeeie?iae/,

Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.Ai?ueeiai IIC
Oe?a?ie, caa?aeoaa/ eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe Oeaeoeei A??a Einei?aia,

?inoeooo oa?ai?? AII Oe?a?ie (i.Oa?e?a), caa?aeoaa/ a?aeae?eii aaiaoeee
aoa?ineea?ico

aeieoi? iaaee/ieo iaoe, i?ioani? ssaeo/ainueeee Ieeiea ?aaiiae/,

Oa?e?anueeee aea?aeaaiee oi?aa?neoao, oaeoeueoao ooiaeaiaioaeueii?
iaaeeoeeie, caa?aeoaa/ eaoaae?e oa?ai??

aeieoi? iaaee/ieo iaoe, i?ioani? Ieioe?i Aieiaeeie? sseiae/,

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
oa?ai?? i?neyaeeieiiii? ina?oe

I?ia?aeia onoaiiaa:

?inoeooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie (i.Ee?a),
a?aeae?e oai?ia i?iea?aeo ? ee?i?/ii? ?aaiaoieia?? oa a?aeae?e aaae
na?oey

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ ________ ” _______________ 1999 ?.
i 1330 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.64.600.04
i?e Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca aae?anith:
310022, i.Oa?e?a, i?. Eai?ia, 4.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i.Oa?e?a, i?. Eai?ia, 4)

Aaoi?aoa?ao ?ic?neaiee “ ________ “ _________________ 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, aeioeaio

Ia/a?aiei E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Ca inoaii? ?iee niinoa??aa?oueny c??no
/enaeueiino? ethaeae ?c caiaeueieie oai?iaaie noaeia?a [Aiiniaa E.I. oa
?io., 1992; Aaiaeaea ?.I., 1995; Neiy/aiei I.A. oa ?io., 1997; Ianiiiaa
A.I. oa ?io., 1998]. Aeooaeuei?noue ai?ioueae c oe??th iaoieia??th
aecia/a?oueny o?aaeaiiyi in?a i?aoeacaeaoiiai a?eo, ui i?ecaiaeeoue aei
aaeeeeo nioe?aeueii-aeiiii?/ieo ao?ao [Oa?eiaaiei I.I. oa ?io., 1995].
Ia ?aaiaoe/i? caoai?thaaiiy a Oe?a?i? ca?ac no?aaeaea? a?ey 3,3 iei
ethaeae [Eiaaeaiei A.I. oa ?io., 1994, 1997]. O oeueiio ca’yceo ?nio?
iaaaeueia iio?aaa i?aeaeuaiiy yeino? ?aiiuei? ae?aaiinoeee a?o?eo?a,
oaeineiiaeaiiy aaea a?aeiii? oa?ai?? oa ?ic?iaee i?eioeeiiai iiaeo
aoaeoeaieo iaoiae?a e?eoaaiiy oaei? eaoaai??? oai?eo [Aecye A.A.,
Eiaeiia N.A., 1995; Iaeei ?.I., Aieiaa/ ?.TH., 1998; Aaaei?ia E.ss.,
Aaioea O.I., 1997; Iaoyaeaiei A.C., Iaeue/aanueea O.?., 1998].

Aei iaea?eueo /anoeo a?noea?aeueieo i?iya?a oai?ia noaeia?a iaeaaeeoue
o?aaeaiiy na?oey, yea /anoi-aonoi aecia/a? ia?aa?a ? i?iaiic caiaeueieo
caoai?thaaiue iii?ii-?ooiaiai aia?aoo [Eiaaeaiei A.I. oa ?io., 1994;
A?on?i N.?., Aeaeo?ei O.TH., 1998]. I?e oeueiio ci?ie ?icaeaathoueny a
i?iea?ae?, ia?eea?ae? oa aiaeiea?ae? (?ieiee c oi?ioaaiiyi eeaiaiieo
aaae na?oey). Ea?ae?aeueia iaoieia?y o oai?eo ia ?A, O?, OA ? IA
ae?aaiinoo?oueny cia/ii ??aea, i?ae aeyaey?oueny i?e iaoieiaiaiaoii?/ieo
aeine?aeaeaiiyo [Aa?in E.A., 1990, Naioaeiaa I.I., Io?aaueia TH.A.,
1991; Neiy/aiei I.A., Aa?eiia A.O., 1994]. Ia oe? iie?a?o?eoo ?
cieaeaiiy o?ce/ii? aeoeaiino? oai?eo iciaee o?aaeaiiy na?oey
ianeothoueny [Aaeaaaiiaa ?.I., 1997]. Ia aeaeue, aeiee a?aenooi?
oe?eani?yiiaai? aeine?aeaeaiiy, ui noinothoueny aea/aiiy
?iciianthaeaeaiino?, iniaeeainoae ia?aa?ao, ieoaiue ?aiiuei?
ae?aaiinoeee ? iaoiaaiaco o?aaeaiiy na?oey i?e caiaeueieo oai?iaao
noaeia?a [Anaoethe ?.E. oa ?io., 1996; Ei?ica N.I. oa ?io., 1997 oa
?io.]. Ona ia?a?aoiaaia aeicaieeei a ?ic?iaeoe i?eioeeii iia? i?aeoiaee
aei e?eoaaiiy oaeeo oai?eo, a oiio i?aeaeueoe ye?noue ?aaa?e?oaoe?eieo
caoiae?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue a?aeiia?aeii aei iniiaiiai ieaio iaoeiai-aeine?aeieo ?ia?o
Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ? ? o?aaiaioii
eiieo?nieo oai IIC Oe?a?ie “Aiae?c ea?ae?iaeai?aneaieo oaeoi??a o oai?eo
c iie?i?aaiiith iaaeinoaoi?noth aeey iaa?oiooaaiiy iaoiae?a
iaoiaaiaoe/ii? oa?ai??” (? aea?ae?a?no?aoe?? 0195V000656),
“Iaa?oiooaaoe, ?ic?iaeoe ? ai?iaaaeeoe iaaee/io oaoiieia?th ae?aaiinoeee
? e?eoaaiiy aeaaaia?aoeaieo, caiaeueieo ? iaoaaie?/ieo caoai?thaaiue
noaeia?a o a??iee?a aoa?eueieo oaoo” (? aea?ae?a?no?aoe?? 019008145),
“Aea/eoe noai aeeiai?/iiai iiaa?oiaaiai iaoyao a?ieia?/ieo ??aeei o
caei?iaeo ethaeae ? oai?eo c ??ciiiai?oieie caoai?thaaiiyie
oa?aiaaoe/iiai i?io?eth” (? aea?ae?a?no?aoe?? 0197V002098).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa aeine?aeaeaiiy – i?aeaeueoe ye?noue
ae?aaiinoeee ? e?eoaaiiy iaoieia?? na?oey i?e caiaeueieo caoai?thaaiiyo
noaeia?a. O ca’yceo c oeei aoei iinoaaeaii oae? caaea/?:

1. Aea/eoe ia?aiao?e ?ino?oiaioaeueieo aeine?aeaeaiue na?oey i?e ?A, O?,
OA ? IA, aeeth/ath/e AEA, oa?iaeieia?/i? ? o?ce/i? iaaaioaaeoaaeuei?
oanoe, AAI, *NAN, OEI, AoiEA, ?A, AOAe.

2. I?iaanoe c?noaaeaiiy oa?aeoa?o ia?aa?ao noaeiaiaiai ? ea?ae?aeueiiai
neiae?ii?a i?e a?o?eoao, aeyaeoe i?iaiiciaaaoeai? e?eoa??? iiaeeeaiai
?icaeoeo ea?ae?iiao?? o oaei? eaoaai??? oai?eo.

3. Aeyaeoe oa?aeoa? ii?oieia?/ieo ci?i ie?aieo no?oeoo? na?oey ca
aeaieie iaoieiaiaiaoii?/iiai aeine?aeaeaiiy, anoaiiaeoe caaaeuei? iciaee
? a?ae??ciyeuei? iniaeeaino? o?aaeaiiy i?iea?aeo, aiaeiea?aeo ?
ia?eea?aeo i?e ie?aieo caiaeueieo oai?iaao noaeia?a.

4. Noai?eoe iiaeaeue iiaeaa?e o oaa?ei ? aecia/eoe oa?aeoa?
ii?oieia?/ieo ci?i a no?oeoo?ao na?oey, ioe?ieoe noai aeaeo?e/ii?
noaa?eueiino? i?iea?aeo, aeine?aeeoe o ia?aia?e oeaiei? ??cieo
a?aeae?e?a iiceo uo??a c a?ia?o?eeai?/iith ea?ae?iiao??th aeoeai?noue
oa?iaio?a io?eiiaiai iai?io ? aeyaeoe ?acaai? iiaeeeaino? iaoaaie?cio
aaeaiiceio.

5. Anoaiiaeoe ?ieue ii?ooaiue nenoaie ?ioi?oaoo, io?eiiaiai e e?i?aeiiai
iai?i?a, ai?iiiaeueiiai noaoono, IIE ? aioeieneaeaioieo nenoai a
iaoiaaiac? o?aaeaiue na?oey i?e ?A, O?, OA ? IA.

6. Aecia/eoe cia/aiiy aeeiai?/ii? i?aeoacii? oaic?iiao??? ne?iaaoee
e?ia? ? ea?ae?iaeai?aneaiiai oaeoi?o aeey ae?aaiinoeee iaoieia?? na?oey
i?e caiaeueieo caoai?thaaiiyo noaeia?a.

7. Aea/eoe /anoioo iin?enoaa aioeaai?a a?noinoi?niino? HLA o oai?eo ia
a?o?eoe c iaoith iiaeeeaiai aeyaeaiiy aaiaoe/ii? noeeueiino? aei
?icaeoeo ea?ae?iiao?? ? i?iaiicoaaiiy o?aaeaiiy na?oey aaea a aeaatho?
caoai?thaaiiy.

8. ?ic?iaeoe ca i?aenoaaith ee?i?ei-aenia?eiaioaeueieo aeine?aeaeaiue
iniaeeainoae iaoiaaiaco ea?ae?iiao?? oaoiieia?th ?iaeea?aeoaeueiiai
e?eoaaiiy caiaeueieo oai?ia noaeia?a c o?aaeaiiyi na?oey, oei naiei
i?aeaeueoe aoaeoeai?noue a?aeiieo oa?aiaaoe/ieo caoiae?a oaei? eaoaai???
oai?eo.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Aia?oa i?iaaaeaii c?noaaeaiiy
ee?i?ei-?aioaaiieia?/ieo ? eaai?aoi?ieo iciae o?aaeaiiy noaeia?a i?e ?A,
O?, OA ? IA c oa?aeoa?ii ia?aa?ao iaoieia?? na?oey o oaei? eaoaai???
oai?eo. Aia?oa i?e aenia?eiaioaeuei?e iiaeaa?? o oaa?ei aea/aii
ii?oieia?th no?oeoo? na?oey oa ?ioiieiiiaoaioieo i?aai?a, a oaeiae noai
?ioi?oaoo ? aeaeo?e/ii? noaa?eueiino? na?oey, aecia/aii o ia?aia?e
oeaiei? ??cieo a?aeae?e?a aieiaiiai iiceo aeoeai?noue oa?iaio?a
io?eiiaiai iai?io ? aeyaeaii ?aca?ai? iiaeeeaino? iaoaaie?cio aaeaiiceio
o naini?i?e ei??, a?iioaeaion? ? a?iieaii?. Aia?oa i?iaaaeaii eiiieaeni?
aeine?aeaeaiiy AEA, aeeth/ath/e oa?iaeieia?/i? ? o?ce/i?
iaaaioaaeoaaeuei? i?iae, AAI, *NAN ia?aaena?aeue oa OEI, AoiEA, ?A ?
AOAe na?oey i?e caiaeueieo caoai?thaaiiyo noaeia?a. Aia?oa o oai?eo c
ea?ae?iiao??th ? aac oaei? i?e a?o?eoao o ii??aiyeueiiio aniaeo? o e?ia?
aecia/aii eiioeaio?aoe?? oieanoa?eio, ?-oieanoa?eio, OA, EIAA, EIIA,
EIAeIA, ae??iiaeo eii’thaao?a, iaeiiiaiai ae?aeueaeaa?aeo, eaoaeace,
noia?ieneaeaeeniooace, oieioa?ieo, NE, ieneio?eiieo, EI, aethoai?io,
ae?oeeio, ania?aaeiiai? eeneioe, 5I, AAeA, aia?ioaiceio-??, A, ?, E, O,
A, I, E, O, O3, O4, OOA, IA A, A2, F2?, a oaeiae ia?aiao?e caaaeueiiai
/enea O- ? A-e?ioioeeo?a, ?o noaiiioeyoe?e, aeoeaiino? e?ioioeeo?a o
?AOE c OAA oa Eii, ooieoe?iiaeueii? aeoeaiino? iaeo?io?e?a o oanoao c?
noao?eieieii-209 ? INO, oeo?e ??cieo aooiaioeo?e, ai?no ?A G, A, I,
Oe?E, ?2-IA, II ne?iaaoee, ??aiae o ia? ea?ae?iaeai?aneaiiai oaeoi?o.
Aia?oa aeiaaaeaii ?ieue aaiaoe/ii? noeeueiino? aei o?aaeaiue na?oey i?e
a?o?eoao ca i?aenoaaith oeeoiaaiaoe/ieo aeine?aeaeaiue. Aia?oa o
ee?i?oe? ? aenia?eiaio? ?ic?iaeaii iia? i?aeoiaee aei e?eoaaiiy
ea?ae?iiao?? o oai?eo ?c caiaeueieie caoai?thaaiiyie noaeia?a c
o?aooaaiiyi aeyaeaieo iniaeeainoae iaoiaaiaco.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aia?oa aecia/aii
i?iaiiciaaaoeai? ee?i?ei-?aioaaiieia?/i? ? eaai?aoi?i? e?eoa???
caiaeueieo caoai?thaaiue noaeia?a oa aioeaaie nenoaie HLA ii
a?aeiioaiith ?icaeoeo ea?ae?iiao?? o oaei? eaoaai??? oai?eo. Aia?oa
iiaeaii ci?ie ia?aiao??a ?ino?oiaioaeueieo aeine?aeaeaiue na?oey i?e ?A,
O?, OA ? IA. Aia?oa ?ic?iaeaii oaoiieia?th ?iaeea?aeoaeueiiai e?eoaaiiy
oai?eo ?c ea?ae?aeueiith iaoieia??th i?e a?o?eoao c aeei?enoaiiyi
aaiini?aoe??, ieaciaoa?aco, iie?oa?iaioieo i?aia?ao?a,
o??eiaeai?anaio?a, a?iie?i?aeai?/ieo cania?a, ?AIO ? AE, ui aeicaieeei
i?aeaeueoe aoaeoeai?noue caaaeueiia?aeiieo oa?aiaaoe/ieo caoiae?a.
Iniiai? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeaii a i?aeoeeo
e?eoaaeueieo onoaiia Aeiiaoeueei?, Eoaainueei?, Oa?e?anueei? ?
Iieoaanueei? iaeanoae, o iaa/aeueiee i?ioean iaaee/iiai aoco,
ae?yeuei?noue 2 iaoeiai-aeine?aeieoeueeeo ?inoeooo?a.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a a io?eiai? ?acoeueoaoe
iaoeiaeo aeine?aeaeaiue ? iniiaiei ? neeaaea?oueny o i?iaaaeaii?
?ino?oiaioaeueiiai ianoaaeaiiy oai?eo, aeeiiaii? aenia?eiaio?a ia
oaa?eiao, niinoa?aaeaii? ca oai?eie a oiiaao iie?ee?i?ee. Iiooeoaa/ai
?ic?iaeaii oaoiieia?th ?iaeea?aeoaeueiiai e?eoaaiiy iaoe??io?a c
o?aaeaiiyi na?oey ? ai?iaaaeaeaiiy ?? o i?aeoeeo ioi?iie caei?ia’y.
Aaoi?ii naiino?eii i?iaaaeaii ia?iaeo io?eiaieo ?acoeueoao?a ? ?o
aiae?c. Aeena?oaioii ia aoee aeei?enoai? ?acoeueoaoe ? ?aea? ni?aaaoi??a
ioae?eaoe?e. Caeiaoaa/ aeneiaeth? aeeaieo iiaeyeo aeieoi?o iaaee/ieo
iaoe, i?ioani?ia? A.O.Aa?eiiao ca eiinoeueoaoe?? i?e aea/aii? ii?oieia??
? iaoiaaiaco o?aaeaiiy na?oey i?e caiaeueieo caoai?thaaiiyo noaeia?a.

Ai?iaaoe?y ?acoeueoao?a ?iaioe. Iniiai? iieiaeaiiy aeena?oaoe?eii?
?iaioe iaaiai?ai? ia tha?eaei?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeooaeuei? i?iaeaie aioo??oiuei? iaoieia?? ? i?neyaeeieiiii?
i?aeaioiaee e?ea??a-oa?aiaao?a” (Ee?a, 1996), iaoeiai-i?aeoe/i?e
eiioa?aioe?? ?aaiaoieia?a Oe?a?ie “No/ania e?eoaaiiy ?aaiaoe/ieo
caoai?thaaiue” (Aeiiaoeuee, 1996), 2 Iaoe?iiaeueiiio eiia?an?
?aaiaoieia?a Oe?a?ie (Ee?a, 1997), 10 ?a?iiaenueeiio neiiic?oi?
?aaiaoieia?a (A?aeaiue, Aano??y, 1997), 14 c’?cae? oa?aiaao?a Oe?a?ie
(Ee?a, 1998), eiioa?aioe?? Aeiiaoeueeiai iaeaniiai oiaa?enoaa oa?aiaao?a
?i. A.I.Ia?acoeiaa (Aeiiaoeuee, 1996, 1998), ni?eueiiio can?aeaii?
eaoaae? i?iiaaeaaoeee aioo??oi?o oai?ia, oieoaeueii? oa?ai??,
i?e?ia?ieia?? oa ?ioiieia?? Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo, ?inoeoooo iaa?aeeeaaeii? ? a?aeiiaethaaeueii? o??o?a?? AII
Oe?a?ie ? Oe?a?inueeiai iaoeiaiai oeaio?o oaoi?/ii? aeieia??
(Aeiiaoeuee, 1999).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii iiiia?ao?th “Iaoieia?y
na?oey i?e a?o?eoao” (16 ?icae?e?a, 324 noi?.) ? 27 iaoeiaeo i?aoeue, a
oiio /ene? 19 noaoae o aeo?iaeao, 4 – o ca??eao. Io?eiaii iaoaio ia
aeiao?ae (? 20885 A, Oe?a?ia).

No?oeoo?a ? ianya aeena?oaoe??. Aeena?oaoe?th aeeeaaeaii ia 309
noi??ieao ae?oeiaaiiai oaenoo ? aiia neeaaea?oueny ?c anooio, 8
?icae?e?a (a oiio /ene? iaeyaeo e?oa?aoo?e, iaoa??ae?a ? iaoiae?a
aeine?aeaeaiiy, 6 ?icae?e?a aeanieo aeine?aeaeaiue), caeeth/ii? /anoeie,
aeniiae?a, nieneo aeei?enoaieo aeaea?ae, yeee i?noeoue 357 iaeiaioaaiue
(36 noi?.), oa aeiaeaoeo. ?iaioo ?ethno?iaaii 41 oaaeeoeath ? 72
?enoieaie.

CAAAEUeIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee. I?ae niinoa?aaeaiiyi ciaoiaeeeenue 468 oai?eo ?c
caiaeueieie caoai?thaaiiyie noaeia?a, na?aae yeeo aoei 209 ethaeae, ui
no?aaeaeaee ia ?A, 73 – ia O?, 37 – ia OA, 149 – ia iiaeaa?o. Ca oiia
iicieia?/ii? ?a/? an?o iaoe??io?a ?iciiae?eaii ia 2 a?oie: 1-o
(eiio?ieueio) neeaee oai?? aac ea?ae?aeueii? iaoieia??, a 2-o (iniiaio)
– c iayai?noth oeo /e ?ioeo iciae o?aaeaiiy na?oey.

Ea?ae?iiao?th i?e ?A anoaiiaeaii o 51,7% oai?eo. Iaoe??ioe c o?aaeaiiyi
na?oey aeyaeeeny a?eueo noa??oeo a?eiaeo a?oi (?2=37,54), o ieo aoee
a?eueoee nooi?iue aeoeaiino? iaoieia?/iiai i?ioeano (?2=7,02),
?aioaaiieia?/ia noaae?y ca Ooaeia?ieea?ii (?2=37,54) ? nooi?iue
ii?ooaiiy ooieoe?? noaeia?a (?2=5,56), /ano?oa ?a?no?oaaany
na?iiiceoeaiee aa??aio oai?iae (?2=16,37).

Ci?ie c aieo na?oey i?e A? aeyaeaii o 39,7% ianoaaeaieo. A?oie oai?eo c
O? a?ae??ciyeeny i?ae niaith ca noaooth (?2=21,01), a?eii (?2=4,26),
nooiaiai aeoeaiino? (?2=3,79) oa aeiaaio?eaaeinoth caoai?thaaiiy
(?2=5,81), ?iciianthaeaeaiinoth a?o?eoo (?2=5,57) oa iayai?noth
nae?i?ea?oo (?2=21,46). On? iaoe??ioe c o?aaeaiiyi na?oey aoee
/ieia?eaie, ui aeicaieyei ?icaeyaeaoe /ieia?/o noaoue ye
i?iaiiciaaaoeaio ii a?aeiioaiith ?icaeoeo ea?ae?iiao?? i?e O?. O?aaeaiiy
e?eaeicaeooaeiieo noaeia?a aeyaeaii o 58,6% oai?eo iniiaii? ? o 9,1%
eiio?ieueii? a?oi, aenieee nooi?iue aeoeaiino? iaoieia?/iiai i?ioeano –
a?aeiia?aeii o 22,7% ? 37,9%.

Ea?ae?aeueio iaoieia?th i?e OA ae?aaiinoiaaii o 62,2% oai?eo (an? aoee
i?aaenoaaieeaie /ieia?/i? noao?). Aiie aeyaeeeny noa?oeo a?eiaeo a?oi
(?2=8,48) ? o ieo /ano?oa eiinoaoiaaii ?icaeoie nae?i?ea?oo (?2=4,77).
Oae, noa?oa 40 ?ie?a aoee a 1-e ? 2-e a?oiao a?aeiia?aeii 14,3% e 47,8%
oai?eo, c e?eaeicaeooaeiiei a?o?eoii – a?aeiia?aeii 42,9% ? 78,3%. A
eiio?ieuei?e a?oi? /anoea ae?iie neeaea 14,3%.

Iniae, ye? no?aaeaeathoue ia IA c o?aaeaiiyi na?oey, oaae aoee noa?oiai
a?eo (?2=4,04), ui aeicaieyei i?e on?o caoai?thaaiiyo noaeia?a
?icaeyaeaoe /aoaa?oo aeaeaaeo aeeooy oai?eo ye iani?eyoeeao o
a?aeiioaii? iiyae ea?ae?iiao??. O i?aaenoaaiee?a 2-? (iniiaii?) a?oie
/ano?oa iaa i?noea oyaeeee ia?aa?a oai?iae (?2=4,03). Iiaeia aaaaeaoe
iani?eyoeeaith uiaei ?icaeoeo iaoieia?? na?oey i?e iiaeaa?? niaaeeiao
noeeuei?noue aei caoai?thaaiiy ca e?i?? aaoueea oa ae?aea.

Aeey iiaeaethaaiiy ii?ooaiue io?eiiaiai iai?io ? iiaeaa?e aoei
aeei?enoiaaii 126 nai/oe?a a?eeo uo??a. Oaa?eiai o ?aoe?ii? aeaaaee
aooie?cao ae??aeaeae?a (aeaea?aei io?ei?a) c iie?aaeaoii aiii?th
(noeioeyoi?ii EI) oa ?iiceiii (iiia?aaeieeii NE). Ia oae?e ae??o? uo??a
o?eiaee i?ioyaii 4 oeaeaei?a. Ii 10-15 aei?a ?icaeaaany a?o?eo. A oiiaao
?iaaeyoe?eiiai ao??iiai aai aioo??oiuei/a?aaiiai iaiaooaeiaiai (50
ia/ea) ia?eico ia oeueiio aoai? uo??a aeaiaeeee ?c aenia?eiaioo. sseui a
eiio?ie? (?ioaeoi? oaa?eie) ??aaiue NE o ne?iaaooe? e?ia? neeaaeaa
100±10 ieiieue/e, oi a aenia?eiaioaeuei?e a?oi? – 264±19 ieiieue/e.
Ie??i NE o e?ia? oaa?ei aeine?aeaeoaaee oeo?e aioeo?e aei iaoeaii? ?
aeaiaoo?iaaii? AeIE, aioeaaiai na?oey, oeiono ? naeac?iee (a ?aaeoe??
ianeaii? aaiaaethoeiaoe??), oaaioeeoa?io aeoeai?noue iaeo?io?e?a ?
ia?eoiiaaeueieo iae?ioaa?a o oanoao c? noao?eieieii (ooai-209) oa INO
(“Lachema”, *ao?y).

O 24 aino?eo aeine?aeao aecia/aee ia?aiao?e aeaeo?e/ii? noaa?eueiino?
na?oey. Ioe?ithaaee ?aaeoe?th na?oey ia iiae?aciaiiy ia?eoa?e/iiai
e?ioey aeoeath/iai ia?aa (i?yiieooi? ?iioeuene, /anoioa 20 Aoe) ca
aeiiiiiaith aeano?inoeioeyoi?a ANE-2 i?e nee? no?oio, ui aei??aith? ?,
?? ? ??? ii?iaai. Na?oea iiae?acithaaee ? /a?ac aeaeo?iae, oaaaeaiee
?io?ai?iea?ae?aeueii o aa?o?aeo i?aaiai oeoii/ea (ia?aae/ani? iiiaeeiie?
i?yiieooi? ?iioeuene o?eaaeinoth 10 inae). Ioe?ithaaee aaee/eio ii?iaa
o?a?eeyoe?? oeoii/e?a. A?ae?aco i?ney i?iaaaeaiiy ooieoe?iiaeueieo
aeine?aeaeaiue a oiiaao ao??iiai ia?eico oaa?ei aeaeai?ooaaee. ?c
aieiaiiai iiceo ia oieiae? (t(=0+4(C) aeae?eyee nainiiioi?io ei?o,
a?iioaeaion ? a?iieaii. O ia?aia?e oeaiei? ??cieo a?aeae?e?a iiceo
aecia/aee aeoeai?noue oa?iaio?a neioaco ? ia?aoai?aiiy aaeaiiceio – 5I ?
AAeA. ?ioaeoi? oaa?eie (10 iniaei) o oe?e na??? neeaee 1-o eiio?ieueio
a?oio. Ua o 36 aenia?eiaioao iaeii?aciai oaiaeeee AeIEA (2,5 ia/100 a
iane). Ooieoe?iiaeuei? aeine?aeaeaiiy ea?ae?iaaiiaeeiai?ee aeeiiaii o 24
uo??a ?c a?ia?o??eai??th /a?ac 1 ? 6 aiaeei ii?ney oaaaeaiiy ai?iiio.
I?e oeueiio a 3-th a?oio aoee aeia?aie oaa?eie c ia?aaaaeiei ii?ooaiiyi
aeaeo?e/ii? noaa?eueiino? na?oey, a a 4-o – c ae?aaeaieie. O yeino?
eiio?ieth noaaaee ?ioaeoi? uo?e, ye? io?eioaaee a ?i’?eoe?yo
a?aeiia?aei? e?eueeino? ?ic/eiieea (2-a eiio?ieueia a?oia, 6 iniaei) ?
AeIEA (3-y eiio?ieueia a?oia, 6 oaa?ei). Ai?no oeeee?/ieo ioeeaioeae?a o
nainiiioi?i?e ei??, a?iioaeaion? ? a?iieaii? aeine?aeaeoaaee ca
aeiiiiiaith oano-iaai??a o??ie “Amersham” (Aaeeea A?eoai?y).

I?iaiaeeeinue ii?oieia?/ia aeine?aeaeaiiy oeaiei na?oey, oeiono ?
naeac?iee uo??a. C??ce caaa?aethaaee aaiaoienee?iii ? aiceiii, ca
Aa?aaoii, aai A?ciiii, Iaeei??, noaaeee PAS-?aaeoe?th, aeeiioaaee
?ii?aaiaoe?th n??aeii ca Aeaeiinii-Iio??.

O ne?iaaooe? e?ia? oai?eo aeine?aeaeoaaee eiioeaio?aoe?? caaaeueiiai
a?eeo, aeueaoi?i?a, o?aeoe?e aeiaoe?i?a ? ?A, Oe?E, ?2-IA, NE,
caaaeueiiai oieanoa?eio, ?-oieanoa?eio, OA, EIAA, EIIA, EIAeIA, IA-A,
IA-A2, IA-F2?, aia?ioaiceio-??, E, A, ?, O, A, I, O, E, O3, O4, OOA.
Aeei?enoiaoaaee i?eeaaee “Eiia-I?ia?an-Iethn”, “Eiia-Niaoeeo?e”,
“I?e?ie?o”, “Oaeaia-I?ioean”, “Aeaeanei”, “Aaiia”, “Ae?A-Iethn” o??i
O?ieyiae??, O?aioe??, ssiii??, Oe?a?ie, Oaaeoea???, ?in??, iaai?e aeey
?aae?i?ioiieo ? ?ioiioa?iaioieo aeine?aeaeaiue ae?iaieoeoa A?ei?on??
(“??A-?2-i?e?i), NOA (“Nlinical Assays”), Oai?ueie (“Institute of
Isotopes”), O?aioe?? (“CIS-International”), ?oae?? (“Sorin TSN
Mallinckrodt – SPAC Mallinckrodt”), Oaaeoea??? (“Buhlman”), Oaaoe??
(“Phadebas”), Aaeeei? A?eoai?? (“Amersham”). Oi?o?eiaaieie iaoiaeaie c
aeei?enoaiiyi oethi?eiao??? ? niaeo?ioioiiao??? aecia/aee ai?no o
ne?iaaooe? iieaciee?a io?eiiaiai iai?io (aeoeai?noue 5I ? AAeA,
eiioeaio?aoe?? ieneio?eiieo, EI, aethoai?io, ae?oeeio ? ania?aaeiiai?
eeneioe), a oaeiae oaeoi?e IIE ? aioeieneaeaioieo nenoai – ae??iiaeo
eii’thaao?a, iaeiiiaiai ae?aeueaeaa?aeo, noia?ieneaeaeeniooace,
eaoaeace, oieioa?ieo.

Na?aae ?ioiieia?/ieo iieaciee?a ioe?ithaaee ai?no O-e?ioioeeo?a ?
A-e?ioioeeo?a o e?ia?, ?o noaiiioeyoe?e, ooieoe?iiaeueio aeoeai?noue
ee?oei o ?AOE ia OAA (“Diphco-P”, NOA) ? Eii (“Sigma”, COA),
eiioeaio?aoe?? ?A G, A, I, ??aaiue aioeo?e aei iaoeaii? AeIE,
i?ioeea?ae?aeueieo, i?ioeoeionieo ? i?ioenaeac?ieiaeo aioeo?e ca
?aaeoe??th ianeaii? aaiaaethoeiaoe??, oaaioeeoa?io aeoeai?noue
iaeo?io?e?a o oanoao c? noao?eieieii-209 ? INO. O eaoaen-oano? ?
?aaeoe?? Aaaea?-?ioca aecia/aee oeo?e ?aaiaoi?aeiiai oaeoi?o a e?ia?.
Caaeey aeyaeaiiy aioeaai?a a?noinoi?niino? aeei?enoiaoaaee eiia?oe?ei?
ne?iaaoee “Behring” (I?ia//eia), “Biotest” (I?ia//eia), “Pel-Freez”
(NOA), “Hoechst” (I?ia//eia) ? Naieo-Iaoa?ao?cueeiai IAe? aaiaoieia??
(?in?y).

Aeeiai?/iee II ne?iaaoee e?ia? ? na/? aea/aee ca aeiiiiiaith
eiii’thoa?ieo oaic?iiao??a I?O1 ? I?O2 (“Lauda”, I?ia//eia). Ia
oaic?ia?aiao (e?eaeo caeaaeiino? II a?ae /ano) eiii’thoa? aecia/aa
oi/ee, ui a?aeiia?aeaee t=0,01 nae (II1), t=1 nae (II2) oa t?? (II3).
Inoaiiy a?aeia?aaeaea ??aiiaaaiiee (noaoenoe/iee) II. Ie??i oiai,
i?ae?aoiaoaaee EIE a eii?aeeiaoao II t—1/2. Caaeey eiio?ieth ianoaaeaii
68 i?aeoe/ii caei?iaeo ethaeae (35 /ieia?e?a ? 33 ae?iee o a?oe? a?ae 15
aei 69 ?ie?a).

On?i oai?ei cae?enithaaee AEA ia aia?aoao “AE-1O-03I2” (?in?y) aai
“Fukuda Denshi Cardimax-FX326” (ssiii?y). Ca iaiao?aei?noth
i?iaiaeeeenue oa?iaeieia?/i? i?iae c iiaiea?iai?aeii, iaceaeaiii,
ao?ii?iii, ae?i???aeaiieii. OEI aeeiioaaee ca aeiiiiiaith nenoai
aia?aoo?e “No??/ea-IO”. Oiea?aioi?noue aei o?ce/iiai iaaaioaaeaiiy
aea/aee ca aeiiiiiaith AAI ia aaeia?aiiao?? “EA-12” (Oai?ueia). ??
aeeiiaii o 34 oai?eo ia ?A, 16- ia IA ? 13 – ia O?. O yeino?
aeueoa?iaoeae ae?aaiinoe/ii? AAI i?e oai?iaao noaeia?a aoea *NAN
ia?aaena?aeue (aeei?enoiaoaaee a?iiey?iee aeaeo?iae “IAAeNI-2” ?
ea?ae?inoeioeyoi? “Servocard SC 100N-Hellige”). *NAN aeeiiaii o 27
oai?eo ia ?A, 9 oai?ei ia O?, 15 – ia IA. I?e *NAN o 14 oai?eo ia ?A ?
12 ia IA aea/aii iaoiaeii oao?aiiey?ii? a?oaeii? ?A iieacieee
ea?ae?iaaiiaeeiai?ee. Aeei?enoiaoaaee ?aiieao?ciia?ao “?IA2-02”, a aeey
?aa?no?aoi?a – iie?a?ao “6-IAE-401” (I?ia//eia).

Oeueo?acaoeiaa aeine?aeaeaiiy na?oey i?iaiaeeee ia aia?ao? “Hewlett
Packard” (COA) c i?ae?aooaaiiyi CINI ? iai?oaeaiiy no?iee e?aiai
oeoii/ea o nenoieo. O 23 oai?eo ia ?A, IA ? OA canoiniaoaaee
no?an-AoiEA.

Caaeey AOAe na?oey aeei?enoiaoaaee ea?ae?ieiiieaen “Cardioquick (Prucka
Engineering)”, aiaeiea?ae?aeuei? aeaeo?iaee “Medtronic” ? “IAAeI-6”,
aeaeo?iea?ae?inoeioeyoi? “Biotronic”, ?aioaai?anueeee aiia?ao
“Phillips”. Aeaeo?iea?ae?inoeioeyoe?th aeeiioaaee c /anoioith
60-70-80-90-100-120-140-170-200 ?ii/oa. Aeey aecia/aiiy A?II i?iaiaeeee
i?ia?aiiaaio aeaeo?inoeioeyoe?th na???th o 5-10 ?iioeuen?a c ianooiiith
cao?eieith ?iioeueno a?ae 500 aei 250 inae oa ?ioa?aaeii o 10 inae.
Aeyaeaiiy ia?ieneci?a oao?a?eoi?e cae?enithaaee oeyoii iaae/anoi?
aeaeo?iea?ae?inoeioeyoe?? (200-300-400-500-600 ?ii/oa).

Aeey aecia/aiiy ea?ae?iaeai?aneaiiai oaeoi?o ?c ne?iaaoee e?ia?
iaoiaeii aaeue-o?iiaoia?ao?? ia eieiioe? “LKB” (naoaaeaen G-25, Oaaoe?y)
a?aeae?eyee ie?ai? o?aeoe?? c ianooiiith ioe?ieith ?o ea?ae?io?iiieo
aoaeo?a. A?aea?? aetheiaaieo o?aeoe?e i?iaiaeeee ca aeiiiiiaith
eieaeoi?a “Yargo” ? eiioeaio?oaaee o /a?oieao “Millipore CX-30”.
Iieaeoey?io iano niieoee, ui i?noeoueny o iaea?eueo oiene/i?e o?aeoe??
(ii a?aeiioaiith aei nei?i/aiiy ?cieueiaaiiai na?oey aeaae), aecia/aee
aaeue-o?eueo?aoe??th, a eieiieo eae?a?iaaee ?inoe?iii ? na?ioii?iii.
Aeine?aeaeaiiy i?iaaaeaii ia ?cieueiaaieo i?aoethth/eo na?oeyo uo??a
Wistar, eio?? aeeo/aee c i?aai?cio oaa?ei i?ney ?iaaeyoe?eiiai ia?eico
ao??ii-iia?o?yiith noi?ooth. Aeey ?a?no?aoe?? ooieoe?iiaeueieo
iieaciee?a o ii?iaeieio e?aiai oeoii/ea oaiaeeee eaitheth, yeo
c’?aeioaaee c oaic?iaeao/eeii aeaeo?iiaiiiao?e/iiai i?eeaaea
“Ooea/-?-2A”. Aeey aei??thaaiiy aaee/ei na?oeaaiai aeeeaeo a ai?oaeueio
iaa?no?aeue aeaooiaoaaee i?ioi/iee aeao/ee aeaeo?iiaai?oiiai oeioiao?o
“?EA-3I”. ?a?no?aoe?th e?eaeo aioo??oiueioeoii/eiaiai oeneo ? aeaieo
oeioiao??? i?iaiaeeee i?eno?i?i “I338/6”. ?ic?aoiaoaaee aaee/eie NOeo ?
AeOeo, a oaeiae +dP/dT ? -dP/dO aioo??oiueioeoii/eiaiai oeneo. Aeey
aeyaeaiiy caoiaaieo ii?ooaiue ooieoe?? i?iea?aeo i?iaiaeeee i?iae c
i?aeaeuaiiyi ia?aae- ? iinoiaaaioaaeaiiy ca ?aooiie ca?eueoaiiy,
a?aeiia?aeii, oeneo a e?aiia?aaena?aeiueiio ? ai?oaeueiiio
noaa?e?caoi?ao.

Noaoenoe/io ia?iaeo iaea?aeaieo aeaieo aeeiiaii ia eiii’thoa?? c
aeei?enoaiiyi noaiaeao?oieo iaeao?a i?ia?ai “M?crosoft Excel”.

Ae?aaiinoeea iaoieia?? na?oey i?e a?o?eoao. Ca aeaieie AEA a?ia?o?io?th
e?aiai oeoii/ea i?e ?A anoaiiaeaii o 47,2% aeiaaee?a, e?aiai
ia?aaena?aey – o 6,5%, i?aaiai oeoii/ea ? i?aaiai ia?aaena?aey – o 0,9%,
ia?aooeaao a?eoi?th ? AIIIA – o 1,9%, aeno?anenoie?/io a?eoi?th – o
9,3%, AEIIA – o 14,8%, ao??iaaio?eeoey?i? aeieaaee – o 2,8%, ii?ooaiiy
aioo??oiueioeoii/eiai? i?ia?aeiino? – o 5,6%, ii?ooaiiy ?aiiey?ecaoe??
i?iea?aea – o 3,7%, aeeooci? ci?ie i?iea?aea – o 45,4%.

Ca?aeii oeueo?acaoeiaiio aeine?aeaeaiith ca?eueoaiiy oiaueie caaeiuei?
no?iee e?aiai oeoii/ea oa i?aeoeoii/eiai? ia?aoeiee aeyaeaii
a?aeiia?aeii o 57,1% ? 28,6% oai?eo, ae?eaoaoe?th ii?iaeiei e?aiai
oeoii/ea ? ia?aaena?aey – o 16,7% ? 7,1%, ?icoe?aiiy ? ou?eueiaiiy ai?oe
– o 11,9% ? 81,0%, ou?eueiaiiy i?o?aeueiiai, ai?oaeueiiai e
o?eeoni?aeaeueiiai eeaiai?a – a?aeiia?aeii o 45,2%, 59,5% ? 2,4%,
ou?eueiaiiy ia?eea?aeo oa ciaioaiiy o?aeoe?? aeeeaeo – o 4,8%,
i?o?aeueio ? ai?oaeueio ?aao?a?oaoe?? – a?aeiia?aeii o 40,5% ? 9,5%,
ae?anoie?/io aeenooieoe?th e?aiai oeoii/ea – o 23,8%.

Ci?ie AEA aeyaeaii o 35,6% oai?eo ia OA. A?ia?o?io?th e?aiai oeoii/ea
anoaiiaeaii o 23,3% a?ae caaaeueiiai /enea oai?eo ? o 58,6% a?ae /enea
iaoe??io?a c iaoieia??th na?oey, AIIIA – a?aeiia?aeii o 11,0% ? 27,6%,
aeeooci? ci?ie i?iea?aea – o 9,6% ? 24,1%, ii?ooaiiy
aioo??oiueioeoii/eiai? i?ia?aeiino? – o 8,2% ? 20,7%, ii?ooaiiy
?aiiey?ecaoe?? i?iea?aea – o 6,9% ? 17,2%, AEIIA – o 5,5% ? 13,8%,
aeno?anenoie?/i? a?eoi?? – o 4,1% ? 10,4%, a?ia?o?io?th e?aiai
ia?aaena?aey ? ao??iaaio?eeoey?i? aeieaaee – o 2,7% a 6,9%, ia?aooeaao
a?eoi?th, a?ia?o?io?th i?aaiai oeoii/ea ? i?aaiai ia?aaena?aey – o 1,4%
? 3,5%.

Ci?ie AoiEA aeyaeaii o 31,5% ianoaaeaieo. Ca?eueoaiiy caaeiuei? no?iee
e?aiai oeoii/ea i?e O? iaee i?noea o 44,8% iaoe??io?a c ea?ae?aeueiith
iaoieia??th, ou?eueiaiiy i?o?aeueiiai eeaiaio – o 34,5%, ou?eueiaiiy
ai?oe – o 27,6%, i?o?aeueio ?aao?a?oaoe?th – o 20,7%, ca?eueoaiiy
ii?iaeieie e?aiai oeoii/ea ? oiaueie i?aeoeoii/eiai? ia?aoeiee – o
17,2%, ca?eueoaiiy ii?iaeieie e?aiai ia?aaena?aey, ou?eueiaiiy
ai?oaeueiiai eeaiaio, ai?oaeueio ?aao?a?oaoe?th ? ae?anoie?/io
aeenooieoe?th e?aiai oeoii/ea – o 10,4%, ciaioaiiy o?aeoe?? aeeeaeo – o
6,9%, ?icoe?aiiy ai?oe – 3,5%. Ca AEA-aeine?aeaeaiiyi aeey O? aeyaeeeny
i?eoaiaiieie ii?ooaiiy aioo??oiueioeoii/eiai? i?ia?aeiino? oa neiae?ii
?aiiuei? ?aiiey?ecaoe?? oeoii/e?a.

Aeey OA aoee oeiiaeie aeno?anenoie?/i? a?eoi??, AIIIA ?
ao??iaaio?eeoey?ia aeieaaea ? nooiaith, a a?aeiinii ??aeei ?icaeaaeeny
a?ia?o?io?? e?aiai oeoii/ea ? i?aaiai ia?aaena?aey. Iaaeoeoii/eia?
aeno?anenoiee i?e OA aoee a?aenooi?. I?e oeoii/eia?e aeno?anenoie?? o
oai?eo ia OA a?aecia/aany ia?aaeienaeueiee ?oo i?aeoeoii/eiai?
ia?aoeiee, neio?iiiee ?c coaoeii R AEA.

IA /anoi i?iyaeyany a?ia?o?io??th e?aiai ia?aaena?aey oa ieaioeeaith
a?eoi??th ( o 4,7% a?ae caaaeueiiai /enea oai?eo ? o 5,7% a?ae /enea
oai?eo c ea?ae?aeueiith iaoieia??th). O?a?eeyoe?y ia?aaena?aeue cia/ii
/ano?oa ?a?no?oaaeany i?e ?ioa?i?ooth/?e oi?i? IA ? ci?oaiiio oei?
a?ia?o??eai??. Aeno?anenoie?/ia a?eoi?y aeyaeyeany o 6,0% oai?eo (na?aae
in?a c ?ioeie ci?iaie c aieo na?oey – o 7,4%), ye i?aaeei o aeiaaeeao
oyaeeiai ia?aa?ao noaeiaiaiai oa ie?eiaiai neiae?ii?a. Ni?aa?aeiioaiiy
“ia?aaena?aei? – i?aaioeoii/eia? – e?aioeoii/eia? aeno?anenoiee”
neeaaeaei ye 1:2:3. Ci?ie AEA i?e iiaeaa?? ca?a?no?iaaii o 81,9% oai?eo.
A?ia?o?io?th e?aiai oeoii/ea aeyaeyee o 43,0% ianoaaeaieo ? o 52,5% a?ae
/enea iaoe??io?a c iaoieia??th na?oey. Aiie?ooaei? “aieueoaaei?”
ii?ooaiiy a?aecia/aii o 95,0%, i?e/iio ii?aeiaiiy aeaio ? a?eueoa iciae
eiinoaoiaaii o iiiaae iieiaeie c ieo. ??ciiiai?oi? ii?ooaiiy
i?ia?aeiino? aeyaeaii o 24,8% oai?eo ia IA, a na?aae in?a c na?oeaaith
iaoieia??th ??ci? aeieaaee iaee i?noea o eiaeiiai o?aoueiai
ianoaaeaiiai. Caaaeii, ii?ooaiiy aioo??oiueioeoii/eiai? i?ia?aeiino?
eiinoaoiaaii a 8,1% niinoa?aaeaiue, AIIIA – o 7,4%, ao??iaaio?eeoey?ia
aeieaaea ? nooiaith – a 5,4%, AEIIA – o 4,0%. Oe? ci?ie i?ia?aeiino?
ca?a?no?iaaii a?aeiia?aeii o 9,8%, 9,0%, 6,6% ? 4,9% oai?eo c iayai?noth
?ioeo ci?i c aieo na?oey. AEIIA ? AIIIA ae?aaiinoiaai? aeeeth/ii o
oai?eo c o?ii?/iith oi?iith IA ? iaoaaie?/iiio oei? a?ia?o?eeai??, oiae?
ye ii?ooaiiy aioo??oiueioeoii/eiai? i?ia?aeiino? ? ao??iaaio?eeoey?i?
aeieaaee iaei caeaaeaee a?ae noaeiaiaiai neiae?iio e oeio ii?ooaiue
io?eiiaiai iai?io.

Ci?ie neioniaiai ?eoio ? aeoii?/i? a?eoi?? o oai?eo ia ?A, O?, OA ? IA
iaee caeaaeaoe a?ae aaaaoaoeaieo ii?ooaiue aiane?aeie noiooiuei?
iae?ioee?eoeyoi?ii? aeenoii??. No?eea aeno?anenoie?y aoea aeoaea
oa?aeoa?iith aeey IA ? ae?ae ??aeei cono??/aeany i?e O?. I?e
a?aaeenenoie?yo o oai?eo ia ?A aeenooieoe?th neioniaiai aocea aeyaeaii
eeoa o eiaeiiai aeanyoiai oai?iai, i?e/iio o an?o aeiaaeeao iaea i?noea
iiceoeaia ia?aneiiaoe/ia aeieaaea o oano? c ao?ii?iii. NNNA o oaei?
eaoaai??? oai?eo ia niinoa??aaany.

AoiEA-ci?ie i?e caiaeueieo caoai?thaaiiyo noaeia?a aoee aeiaie?
??ciiiai?oi?. Iniaeeai oea noinoaaeiny oai?eo ia ?A ? IA. Naia oaeei
a?oiai a?eueo i?eoaiaii? ou?eueiaiiy ai?oe, ciaioaiiy o?aeoe?? aeeeaeo
e?ia? ? ae?anoie?/ia aeenooieoe?y e?aiai oeoii/ea. O?eueee i?e ?A
anoaiiaeaii aei?o o ia?aea?ae?aeueio ii?iaeieio, oi/a ou?eueiaiiy
eenoe?a ia?eea?aeo cono??/aeiny i?e O? ? IA. *anoioa ooyaiaiiy a
iaoieia?/iee i?ioean ai?oe oa ai?oaeueiiai eeaiaio o oai?eo ia O? cia/ii
iinooiaeany oaei? i?e ?ioeo caoai?thaaiiyo noaeia?a. Ianiiae?aaiii
aenieeie aeyaeeeny oe? iieacieee i?e IA, eio?ee ua a?ae??ciyany
noiaoaiiyi i?aeoeoii/eiai? ia?aoeiee ? ca?eueoaiiyi ii?iaeieie e?aiai
ia?aaena?aey.

Ia?aiao?e aeiiiea?-AoiEA i?e oai?iaao noaeia?a iaei a?ae??ciyeeny i?ae
niaith ? eeoa oaeaee?noue nenoie?/iiai iioieo a ai?o? i?e IA aoea cia/ii
iaioith, ai?ae o oai?eo ia ?A, O? ? OA. Iioe?aiiy ai?oe o oai?eo ia IA
(>3,9 ni) niinoa??aaeiny o 12,5% aeiaaee?a (o 5,7% c ieo aeyaeaii
iaaeinoaoi?noue ai?oaeueiiai eeaiaio c ?aao?a?oaoe??th ??-??? nooiaith),
ca?eueoaiiy e?aiai ia?aaena?aey – o 35,2% oai?eo, e?aiai oeoii/ea – o
14,8%.

Ca?eueoaiiy e?ioeaaiai ae?anoie?/iiai ?ici??o ? ia’?io e?aiai oeoii/ea o
iaaeao 7,05 ni oa 260 ie ca?a?no?iaaii o 14,8% oai?eo, na?aae yeeo o
92,3% aeyaeaii ecieueiaai? ? niieo/aii? aaaee ai?oaeueiiai ?
i?o?aeueiiai eeaiaio, a o 7,7% — AEIIA. ?ici??e i?aaiai oeoii/ea o?ioe
ca?eueooaaeeny eeoa o oai?eo c AIIIA. Iieacieee nei?i/oaaeueii? ooieoe??
i?iea?aeo (nooi?iue ia?aaeiueicaaeiueiai nei?i/aiiy, o?aeoe?? aeeeaeo,
oaeaee?noue oee?eoey?iiai nei?i/aiiy) iaei ci?ithaaeenue. O?eueee o
13,6% oai?eo aeaecia/aii ciaioaiiy o?aeoe?? aeeeaeo, i?e/iio o 2/3 c
ieo- iacia/ia e o 1/3 – ae?aaeaia (<50%). O eiaeiiai ae?oaiai oai?iai c iecueeith o?aeoe??th aeeeaeo ca?a?no?oaaii AEIIA; oaeei iaoe??ioai i?eoaiaii? oyaeeee ia?aa?a IA, iaoaaie?/iee ? ci?oaiee oeie a?ia?o?eeai??. O 22,7% oai?eo eiinoaoiaaii a?ia?eeiaoe/iee oei e?iaiia?ao c? ca?eueoaiiyi o?aeoe?? aeeeaeo (>70%). I?e ?ioa?i?ooth/iio
IA ia?aiao?e AoiEA ci?ithaaeeny iaei. Anoaiiaeaii ca?eueoaiiy
ae?anoie?/ii? oiaueie i?aeoeoii/eiai? ia?aoeiee (1,22±0,019 ni) ?
caaeiuei? no?iee e?aiai oeoii/ea (1,18±0,011 ni) a?aeiia?aeii o 50,0% ?
44,3% oai?eo, i?e/iio a 34,1% niinoa?aaeaiue aeyaeaii ?o ii?aeiaiiy (o
70,0% aeiaaeeao iaea i?noea eiioeaio?e/ia a?ia?o?io?y aac ca?eueoaiiy
ia’?io e?aiai oeoii/ea ? a 30,0% — aenoeaio?e/ia c? ca?eueoaiiyi
e?ioeaaiai ae?anoie?/iiai ia’?io e?aiai oeoii/ea). A?ia?o?io?th e?aiai
oeoii/ea cia/ii /ano?oa ae?aaiinoiaaii i?e o?ii?/iiio aa??aio? IA. O
oaeeo oai?eo aoee yaii aeua iana ? ?iaeaen iane i?iea?aea e?aiai
oeoii/ea. O 10,2% oai?eo ia IA c ia?eoa?e/ieie oioonaie aecia/aeeny
ae?eyiee a?ia?aoiaaiiino? o i?aeoeoii/eia?e ia?aoeioe? (o 2/3) ? a
caaei?e no?ioe? e?aiai oeoii/ea (o 1/3). I?e AoiEA o aeiaeiiai
ianoaaeaiiai ia aeyaeaii eieaeueieo cii a?ii- ? ae?iaec??, ui na?ae/eei
a i?i ?oai?/i? (?oaoeia?) ci?ie i?iea?aeo.

Na?aae oai?eo c ?cieueiaaiith i?o?aeueiith iaaeinoaoiinoth (35,7% a?ae
caaaeueiiai /enea iaoe??io?a c iiaeaa?e/ieie aaaeaie na?oey) ca?eueoaiiy
o?aeoe?? aeeeaeo eiinoaoiaaii o 20,0%. Na?aae oai?eo c ?cieueiaaiith
ai?oaeueiith iaaeinoaoiinoth (25,0% a?ae caaaeueiiai /enea iaoe??io?a c
iiaeaa?e/ieie aaaeaie na?oey) iaee i?noea ca?eueoaiiy e?aiai
ia?aaena?aey ? e?aiai oeoii/ea, a oaeiae o??iio?iiy ia?aaeiuei? nooeee
i?o?aeueiiai eeaiaio (o 42,9% oai?eo), o?a?ic nooeie (o 57,1%, i?e/iio o
28,6% c aeaiaioaie a?ia?aoiaaiino? ??cieo ae?eyiie). Iaaeinoaoi?noue
ai?oaeueiiai eeaiaio ? nooiaith eiinoaoiaaii o 28,6% aeiaaee?a, ??-???
nooiaith – o 71,4%. Na?aae oai?eo c? niieo/aiith i?o?aeueii-ai?oaeueiith
iaaeinoaoiinoth (28,6%) ca?eueoaiiy e?aiai ia?aaena?aey niinoa??aaeiny o
37,5% aeiaaee?a, a e?aiai oeoii/ea – o 25,0%.

Ia iie?ea?ae?ia?aiao i?e caiaeueieo caoai?thaaiiyo noaeia?a aeyaeyeeny
ii?ooaiiy ooieoe?iiaeueiiai noaio i?iea?aea e?aiai oeoii/ea na?oey. Aiie
oa?aeoa?ecoaaeeny ca?eueoaiiyi o?eaaeino? oace iai?oaeaiiy ca ?aooiie
?ciiao?e/iiai nei?i/aiiy, ciaioaiiyi aioo??oiueinenoie?/iiai iieacieea ?
oaeaeeino? i?aeeiio aioo??oiueioeoii/eiaiai oeneo. I?e ?A-aeine?aeaeaii?
aeyaeyeeny iciaee ci?ie aaiiaeeiai?ee o iaeiio eie? e?iaiia?ao ?
oaiaeaioe?y aei iia??oaiiy ooieoe?iiaeueiiai noaio i?iea?aea i?aaiai
oeoii/ea. Ii?ooaiiy ?A oa?aeoa?ecoaaeeny i?aeaeuaiiyi o?eaaeino? oace
iai?oaeaiiy nenoiee i?aaiai oeoii/ea, ciaioaiiyie aaee/ei iaoai?/iiai
eiao?oe??ioo, aioo??oiueinenoie?/iiai iieacieea, ca?eueoaiiyie ?iaeaeno
iai?oaeaiiy i?iea?aeo oa /ano iia?eueiiai iaiiaiaiiy. Cnoae o
ooieoe?iiaeueiiio noai? i?iea?aea iaee oaiaeaioe?th aei c?inoaiiy ca
ca?eueoaiiyi o?eaaeino? caoai?thaaiiy ? aeoeaiino? iaoieia?/iiai
i?ioeano. ?A-iciaee ii?ooaiiy aeanoe/iino? ? i?aeaeuaiiy oiiono noaeei
iaeiai eae?a?o a nenoai? eaaaiaaiai e?iaiia?ao niinoa??aaeeny o
a?eueoino? oai?eo ia ?A. Aioo??oiueina?oeaaa aaiiaeeiai?ea i?e a?o?eoao
oa?aeoa?ecoaaeany ia?aaaaith iiaiiai aai ia?oeeaeueiiai neiae?iio
a?iiaeeiai?? iaeiiai /e iaio oeoii/e?a na?oey. I?e oeueiio aaee/eie
aneio?iiiiai oa ?ciiao?e/iiai nei?i/aiiy, ia??iae?a iai?oaeaiiy oa
aeaaiyiiy, aioo??oiueinenoie?/iiai iieacieea, eiao?oe??io?a Aethiaa?aa?a
iaio oeoii/e?a aoee iaioa, i?ae a eiio?ie?, a ?iaeaen i?iea?aeo ?
aaiiaeeiai?/iee iieaciee – a?eueoa.

I?e *NAN ia?aaena?aeue iaoiaeii oao?aiiey?ii? a?oaeii? ?A aea/aii
iieacieee ea?ae?iaaiiaeeiai?ee o oai?eo ia ?A ? IA. I?iaaaeaiiy *NAN o
a?oi? oai?eo ia iiaeaa?o noi?iaiaeaeoaaeiny cieaeaiiyi na?oeaaiai
aeeeaeo ca ?aooiie oaea?iiai ?iaeaeno, a oaeiae iiaeaeuaiiyi oeneo
iaiiaiaiiy e?aiai oeoii/ea. O oai?eo ia ?A i?e *NAN cieaeaiiy oaea?iiai
?iaeaeno ? ca?eueoaiiy oeneo iaiiaiaiiy e?aiai oeoii/ea iineei iaio
ae?aaeaiee oa?aeoa?.

AOAe na?oey i?iaaaeaii o oai?eo ?A ? IA c NNNA. No?eea neioniaa
a?aaeeea?ae?y i?e neiae?ii? a?aaee-oao?ea?ae?? c /anoioith na?oeaaeo
nei?i/aiue (<40 ca oaeeeio) niinoa??aaeany o 1/3 oai?eo, n?ieiiaeuei? noaie – o ?, /anoa aeno?anenoie?y (>10 ca aiaeeio) – o 1/5.
Niinoa??aaeiny ca?eueoaiiy ONOe, *AONA ? *NAI, i?aeaeuaiiy E*AONA ?
ciaioaiiy A?II. Oeoii/eiaa ?iieaioaoe?y aeaeo?inoeioeyoi?a i?ecaiaeeea
aei ua a?eueoiai c?inoaiiy ONOe, oiae? ye ?iieaioaoe?y o ia?aaena?aey oa
aeaieaia?ia aeaeo?iea?ae?inoeioeyoe?y aeeeeeaee ciaioaiiy oeueiai
aeaeo?io?c?ieia?/iiai iieacieea. O?ainaaiicia aeaeo?iaeano?oeoe?y aai
aaeyoe?y ao??iaaio?eeoey?iiai c’?aeiaiiy ni?eyee ii?iae?caoe?? A?II.

O?aeoe?? e?ia? ??cieo oai?eo, ui i?noeee ea?ae?iaeai?aneaiee oaeoi?,
a?iioaoe/ii iiaeii? aoee /eieoe iaeiioeiiaee aieea ia ooieoe?iiaeueiee
noai ?cieueiaaiiai na?oey. Iaeiae aeyaeaii iaaio iicieia?/io
ni?yiiaai?noue aeeiai?ee iieaciee?a ia aoaiao aenia?eiaioo. O oai?eo ia
IA ae?yeeny a?eueo ae?aaeai? ci?ie ii a?aeiioaiith aei ii/aoeiaeo
cia/aiue. sseui i?e ?A aei 2-? oaeeeie o a?eueoiio nooiai? c?inoaa NOeo
? ciaiooaaeiny –dP/dT, oi i?e IA ia oeueiio aoai? i?aeaeuoaaany AeOeo ?
i?eai?/oaaeiny +dP/dT. Aei 5-? oaeeeie i?ney oaaaeaiiy aeno?aeoo o
oai?eo ia ?A ia?a?aoiaai? ia?aiao?e ii/eiaee iaaeeaeaoeny aei aeo?aeieo
cia/aiue, a a a?oi? IA AeOeo ua a?eueoa c?inoaa. I?e IA caa?oaei ia naaa
oaaao aeiaie? ae?aaeaia ca?eueoaiiy +dP/dT ? –dP/dT a i?ioean?
iaaaioaaeoaaeueieo ni?ia, a i?e ?A cieaeaiiy +dP/dT a i?ioean?
ia?aaeiaaaioaaeaiiy.

Aca?iica’ycie o?aaeaiue noaeia?a ? na?oey i?e a?o?eoao. I?e ?A c
o?aaeaiiyi na?oey /ano?oa eiinoaoiaaii na?iiiceoeaiee aa??aio oai?iae
(<0,001), a iieacieee ?aaeoe?? Aaaea?a-?ioca ? eaoaen-oanoo ?noioii ia?aaaaeaee aiaeia?/i? o 2-e a?oi? ianoaaeaieo (a?aeiia?aeii 1:31,5±1,19 ? 1:170,7±1,08, 1:38,1±1,16 ? 1:221,4±1,29). O oai?eo ia ?A 2-? a?oie cia/ii /ano?oa a i?ioean aoyaoaaeeny eeth/e/ii-ae?ii?aeuei?, iea/ia?, e?eoueia? oa eie?ii? noaeiae (noia a?aeiinii? cia/eiino? oaei? eieae?caoe?? a?o?eo?a neeaaeaea 101,1%, oiae? ye o 1-e a?oi? – anueiai 17,0%). I?ae oei o?aaeaiiy i’yniioaeaiaiaeo noaeia?a aeyaeeiny a?eueo oa?aeoa?iei aeey oai?eo aac ea?ae?iiao?? (?2=7,98, p<0,005). Aeano?oeoe?th noaeia?a i?e ?aioaaiieia?/iiio ianoaaeaii? aeyaeaii o 92,1% oai?eo 1-? a?oie ? o 98,1% - 2-? (?2=5,07, p<0,05). Ea?ae?aeueia iaoieia?y /ano?oa niieo/aeany c aeeoociei inoaiii?icii, e?oiieie eenoiiiae?aieie i?ina?oeaiiyie, oco?aoe?yie e?noie, i?aecaeoiaiiyie. Anoaiiaeaii i?yi? ei?aeyoe?ei? ca’ycee oyaeeino? o?aaeaiiy na?oey c ?aioaaiieia?/iith noaae??th oai?iae, ?iaeaenaie ??/? e Eainao??, iieacieeaie ?aaiaoi?aeiiai oaeoi?o a e?ia?. Noaeiaiaee ?aooiie o 1-e a?oi? ianoaaeaieo c O? neeaaeaa 4,3±0,19, a a 2-e – 6,8±0,51, ?iaeaen ??/? – a?aeiia?aeii 7,7±0,35 ? 13,2±0,75, ?iaeaen Eainao?? – a?aeiia?aeii 81,5±4,56 ? 122,5±5,98 (an? a?aei?iiino? noaoenoe/ii aeinoia??i?). C noaeiaiaei ?aooieii ? ?iaeaenii ??/? a??ia?aeii ei?aethaaea oyaee?noue o?aaeaiiy na?oey. Noia?ia a?aeiinia cia/ei?noue iciae o?aaeaiiy noaeia?a o oai?eo aac iaoieia?? na?oey neeaaeaea 53,2%, a o iaoe??io?a c ea?ae?aeueiith iaoieia??th – 255,4%. I?iaiiciaaaoeaieie oaeoi?aie ii a?aeiioaiith o?aaeaiiy na?oey i?e OA aoee aoyaiaiiy a iaoieia?/iee i?ioean e?eaeicaeooaeiieo c’?aeiaiue, e?eoueiaeo oa i?iiaiaai-cai’ynoeiaeo noaeia?a (?2 a?aeiia?aeii neeaaeaa 21,46, 17,21 ? 27,06, p<0,001). Ci?ie ?aioaaiia?ai noaeia?a aeyaeaii o 43,2% oai?eo 1-? a?oie ? o 79,3% - 2-?, a noia a?aeiinii? cia/eiino? ?aioaaiieia?/ieo ia?aiao??a a?aeiia?aeii neeaaeaea 15,8% ? 64,4%. Iayai?noue a?o?eoo e?eaeicaeooaeiieo noaeia?a iina?aaeiuei aeacoaaea ia iiaeeea?noue ?icaeoeo ea?ae?aeueii? iaoieia?? o oai?eo ia OA. Iaaiaee, aeey oaeeo iaoe??io?a aoei iaoa?aeoa?ii aoyaoaaiiy a iaoieia?/iee i?ioean noaeia?a ?oe. Noia?ia cia/ei?noue oeeo iciae iaaaaaoi ia?aaeuoaaea aiaeia?/i? iieacieee o i?aaenoaaiee?a iniiaii? a?oie ianoaaeaieo. Aenieith niaoeeo?/iinoth aeey oai?eo c ea?ae?iiao??th aieiae?ee iaaeieinoaeiaiaee inoaiii?ic (75,3%), ae??ai? eenoiiiae?ai? i?ina?oeaiiy (100,0%), oco?aoe?y e?noie (64,7%), noaoiiae?aeueiee neea?ic (64,6%), neiioii “aaiaoeiai? iaeee” (100,0%), aaiiyeia?noue ca’yce?a o?aaoe?a (100,0%) ? nae?i?ea?o (64,6%). O oai?eo ia IA c o?aaeaiiyi na?oey a 1,7 ?ace /ano?oa cono??/aeeny oyaeeee ia?aa?a noaeiaiaiai neiae?iio ? ia?eoa?e/i? oioone. O?eueee o 2-e a?oi? oai?eo i?e ?aioaaiieia?/iiio aeine?aeaeaii? aeyaeyeeny i?aeaiaeaeaiiy aioo??oiueie?noeiaeie eiiaeiia?aoaie na/ieeneeo nieae ei?oeeaeueiiai oa?o ie?noy, e?oii? e?noeia? oco?e ? inoaie?c oaeaia iaeueoe?a. A?ae oi?ie a?o?eoo iayai?noue aai a?aenooi?noue ea?ae?aeueii? iaoieia?? ia caeaaeaee. sseui o oai?eo 1-? a?oie ?ioa?i?ooth/ee ? o?ii?/iee a?o?eo aeyaeaii a?aeiia?aeii o 44,4% ? 55,6% niinoa?aaeaiue, oi o 2-e – a?aeiia?aeii o 41,0% ? 59,0%. ?icaeoie ci?i n aieo na?oey o oai?eo ia iiaeaa?o ia caeaaeaei a?ae oeio ii?ooaiue io?eiiaiai iai?io: iaoaaie?/iee, ie?eiaee ? ci?oaiee aa??aioe a?ia?o?eeai?? anoaiiaeaii o 51,9%, 11,1% ? 37,0% oai?eo 1-? oa 59,8%, 10,7% ? 29,5% oai?eo 2-? a?oie. Ii?oieia?/i? ci?ie o na?oe? i?e caiaeueieo oai?iaao noaeia?a (ee?i?ei-aenia?eiaioaeueia aeine?aeaeaiiy). I?e iaoieiaiaiaoii?/iiio aeine?aeaeaiith na?oey o 50,0% oai?eo ia ?A niinoa??aaany ea?ae?ineea?ic, o 36,8% - o?aaeaiiy ia?eea?aeo, o 31,6% - neea?ic eeaiai?a ? i?eno?ieiaiai aiaeiea?aeo, o 23,7% - i?iea?aeeo, o 18,4% - ei?iia??o, o 15,8% - aiaeiea?aeeo, o 13,2% - ai?ei?aeic, o 5,3% - ?aaiaoi?aei? aoceeee. Aoea iayai?noue aaneoe?o?a ae??aieo a?oa??e, a?oa??ie, aaioe, eai?ey??o?a, iaa?ye iaaeooi/ii? oeaieie, e?iaiaeeea?a, aeeoocii? ?io?eueo?aoe?? e?ioioeeoaie, iae?ioaaaie, ieaciaoe/ieie ee?oeiaie, iiiaeeiieeie eaeeioeeoaie, ui noi?iaiaeaeoaaeinue ae?aaeaieie aeeno?io?/ieie ci?iaie i’ycaaeo aieieii. Aaneoe?oe iineee i?ie?oa?aoeaiee aai aeano?oeoeaii-i?ie?oa?aoeaiee oa?aeoa? c o?a?eii?aeieie ci?iaie noaeeiii? no?iee. ?aaiaoi?aei? aoceeee aeyaeyeeny o i?iea?ae?, eeaiaiieo no?oeoo?ao na?oey, ia?aaaaeii o i?aeaaeeie i?o?aeueiiai e ai?oaeueiiai eeaiai?a, o cii? o?a?icieo e?eaoeue. Aoceeee aoee iiaeai? aiaieuai o?a?eii?aeiiai iae?ico, aei yeiai i?eeo/aeeny iae?niiiae?aiee aae ?c a?no?ioeeo?a, e?ioioeeo?a, iae?ioaa?a ? ieaciaoe/ieo ee?oei. C??aeee cono??/aeeny a?aaionuee? ee?oeie. O eeaiai? ?aaiaoi?aei? aoceeee ?icoaoiaoaaeeny o oeaio?aeuei?e /anoei?, caeeoay iaiioeiaeaeaiei ia?eoa??th. I?e OA aeyaeyeeny aeeoocia ou?eueiaiiy oa ooiauaiiy no?iee ai?oe, ?icoe?aiiy ?? ae?ea, ou?eueiaiiy i?ai?nyoe?a, ci?ie aiaeiea?aeo o noaai?oaeuei?e cii?. A?noieia?/ia aeine?aeaeaiiy aeicaieeei aeyaeoe ??cueeo a?ia?o?io?th i’ycaaeo aieieii na?oey, o?a?iaeanoic ? neea?ic ai?oaeueiiai e i?o?aeueiiai eeaiai?a, noaai?oaeueiee o?a?ic, o?a?iaeanoic ai?oe c yaeuaie aiaieuaaiai iaa?yeo ?? no?iee. O oai?eo ia iiaeaa?o i’yc na?oey oa?aeoa?ecoaaany iaeii??aeiei iioeiaeaeaiiyi i?iea?ae?ioeeo?a. Ia ia?oeo aoaiao aeieeaea eeoa /anoeiaa ? iai?ioiy aeano?oeoe?y i’ycaaeo ee?oei, eio?a oa?aeoa?ecoaaeany nei?i/aieie na?eii??aie, a iio?i ianoaaaee iaiai?ioi? i?ioeane e?ceno ee?oeiieo no?oeoo? (?iciaae i?io?a?ee, i?oioiiae??e oa ?ioeo i?aaiae ee?oeie) o eiio?aeoo?ieo i?ioeeoao. E?c??iaai? aieieia cai?uoaaeeny niieo/aiioeaieiieie ?oaoeyie. O aeayeeo niinoa?aaeaiiyo o i?iea?ae? cono??/aeeny oeiia? o?aoi? oioone. O oeaio?? oaeeo aoceee?a ia oe? aeeno?io?/ieo ? iae?ioe/ieo ci?i aeyaeyeeny e?enoaee na/iai? eeneioe, /anoi ?icoaoiaai? ?aae?aeueii, iaaeiei yeeo aoea ciia caiaeueii? ?aaeoe?? c i?ie?oa?aoe??th a?no?ioeeo?a, a?aaionueeeo ee?oei, e?ioioeeo?a, ieaciioeeo?a ? o?a?iaeano?a. Iao?een /anoeiai eaeueoeeo?eoaaany c iiyaith na?aeeo aeaiiceo?a e?enoae?/ieo ? aii?oieo nieae na/iai? eeneioe. Iaaeiei oioon?a oi?ioaaeany o?a?icia niieo/ia oeaieia, ui ai?uoaaea aaeeeo e?euee?noue eieaaaiiaeo aieieii. O 5 iiia?eeo oai?eo ia iiaeaa?o (nia?oue o?aieeany aiane?aeie i?ia?anoth/i? ie?eiai? iaaeinoaoiino?) ia naeoe?? aeyaeaii i?o?aeueii-ai?oaeuei? aaaee na?oey (iaaeinoaoi?noue eeaiai?a). I?e iaoiii?oieia?/iiio aeine?aeaeaiiy ii e?ayo i?o?aeueiiai e ai?oaeueiiai eeaiai?a niinoa??aaeeny a?e? ooiauaiiy, a o i?aeaaeeie ? ia aioo??oi?e iiaa?oi? – aaaaoi/enaeuei? ooai?thaaiiy eai’yii? eiiiaeoiino? aeiaoiaaoiai eieuei?o ?ici??aie a?ae 2 aei 15 ii. Aiaeia?/i?, aea iiiaeeiie? ooai?thaaiiy aeyaeaii oaeiae o ?ioei? ai?oe ? i?aeia?aaena?aeiuei? ia?aoeiee. O i?o?aeueiiio e ai?oaeueiiio eeaiaiao ?icoaoiaoaaeeny oioone, ioi/ai? aeaaionueeeie ee?oeiaie ? a?no?ioeeoaie. Iiaeae? a?ae oeaio?o oioona iaee i?noea e?ioioeeoa?i? ?io?eueo?aoe, o?a?iaeanoe ? i?e?ieaeueoeeiaoe ia oe? a?ae?iico ? o?a?icii? niieo/aii? oeaieie c aaeeeith e?eueeinoth eieaaaiiaeo aieieii. O o?eeoni?aeaeueiiio eeaiai? niinoa??aaeeny ae?aaeaia ioei?aeia iaa?yeaiiy, ooiauaiiy eieaaaiiaiai oa?o, a?ae?iic ? neea?ic, aea aac a?aeeeaaeaiiy nieae na/iai? eeneioe. O 96,8% oaa?ei c aenia?eiaioaeueiith iiaeaa?ith aeyaeyeiny ooiauaiiy no?iee ae??aieo a?oa??e ? a?oa??ie i?iea?aeo, ??aiii??ia e oee?eoey?ia, c??aeea naaiaioa?ia. Niinoa??aaeany a?ia?ieac?y i’ycaaeo aieieii noaeei, ?o ieaciaoe/ia i?iniieooaaiiy oa a?ae?iic. A ooiauai?e no?ioe? ae??aieo a?oa??e niinoa??aaeeny e?oaeyno? oa iaaeuei? aaeoie?, a oaeiae i?ie?oa?aoe?y aiaeioae?th. Cono??/aeeny noaeeie c? neea?icii no?iie. O 45,2% niinoa?aaeaiue a?aei?/aany ia?eaaneoey?iee neea?ic, i?e/iio o eiaeiiio ae?oaiio aeiaaeeo a?i niieo/aany c e?ioia?no?ioeeoa?ieie ?io?eueo?aoaie iaaeiai noaeei. E?ioia?no?ioeeoa?io ?io?eueo?aoe?th aeyaeyee o no?ii? i?iea?aea, i?ae ie?aieie ea?ae?ii?ioeeoaie; ?io?eueo?aoe ?icoaoiaoaaeeny noaaiaeiea?ae?aeueii. O 9,7% oaa?ei na?aae ee?oeiiiai ?io?eueo?aoa cono??/aeeny e?oii? iae?ioaae, a ie?ai? c ieo aoee caaaeii a?aaionueeeo ?ici???a. Iaiaaeai? ee?oeii? ?io?eueo?aoe iaaeiei noaeei, c e?oiieie iae?ioacaie o oeaio??, ca no?oeoo?ith iaaaaeoaaee iiaeaa?e/i? oioone, iaeiae iae?ic oeaieie aoa a?aenooi?e. O an?o uo??a a?aecia/aany neea?ic o i?aeaaeeie eeaiaio, o 90% c ieo – c iayai?noth e?ioia?no?ioeeoa?iiai ?io?eueo?aoo. Na?aae ee?oei ?io?eueo?aoo cono??/aeeny iieiae? o?a?iaeanoe, iae?ioaae, iiiaeeiie? a?aaionuee? ee?oeie ? ieaciioeeoe. Anueiai e?ioia?no?ioeeoa?i? ?io?eueo?aoe o no?ii? i?iea?aeo o i?aeaaeeie eeaiai?a ? iaaeiei noaeei a?aecia/aeeny o 67,7% niinoa?aaeaiue, i?e/iio o eiaeiiio aeanyoiio c ieo o ee?oeiiiio ?io?eueo?ao? aeyaeyeeny ieaciioeeoe. O i?iea?ae? 35,5% uo??a aeyaeyeeny a?ia?o?ioiaai? i?iea?ae?ioeeoe. O an?o oaa?ei iaee i?noea aeeno?io?/i? ci?ie i?iea?ae?ioeeo?a, o 80,7% iii??ii? ae?aaeaiino? ? oyaee?, c ae?eyieaie aaeoieueii? ? aee?iai? aeeno?io??, a o 19,4% - o?aaiaioaoe?y i’ycaaeo aieieii. Na?aae aeiaaee?a c? na?aaeiueiaaaeeith ? oyaeeith aeeno?io??th i?iea?ae?ioeeo?a cono??/aeeny ae?eyiee c ??cei oiieeie, ?ieiee a’thiaoenoeie i’ycaaeie aieieiaie, /anoi na?aae iaa?yeo no?iie, oiaoi ci?ie, ui oa?aeoa?ecothoue i?iea?ae?ie?c?n. E?ioia?no?ioeeoa?ia ?io?eueo?aoe?y o i?iea?ae? /ano?oa cono??/aeany i?e ii?ooaiiyo aaiioei?/iiai aa?’??o ? ao?io?? o?eaoeue Aannaeth, ??aea – i?e ao?io?? e?ioi?aeii? oeaieie o oeion?. *?oei? caeaaeiino? i?ae /anoioith iioeiaeaeaiiy i?iea?aeo ? oa?aeoa?ii ii?oieia?/ieo ci?i o oeion? ia anoaiiaeaii. E?ioia?no?ioeeoa?ia ?io?eueo?aoe?y o i?iea?ae? /ano?oa niinoa??aaeany o aeiaaeeao ia?aaaaeaiiy A-caeaaeii? ciie o naeac?ioe? e e?ioiaoceao, ??aea i?e a?ia?ieac?? e?anii? ioeueie naeac?iee ? ao?io?? e?ioi?aeieo oie?eoe?a. Ca’yceo oyaeeino? iioeiaeaeaiiy i?iea?ae?ioeeo?a ?c ci?iaie ia?eoa?e/ieo i?aai?a ?ioiii? nenoaie, oaeiae ye ? oeiono (oeaio?aeueiiai), ia aeyaeaii. ?en. 1. ?iciiae?e aioeaai?a eieon?a A ? A nenoaie HLA o oai?eo ia a?o?eoe (±% a?aeoeeaiue a?ae /anoioe o caei?iaeo ethaeae). I?ei?oea: ? – aac o?aaeaiiy na?oey, ?? c o?aaeaiiyi na?oey; 1-8 – aioeaaie: 1 – A3, 2 – A9, 3 – A10, 4 – Aw19, 5 – A12, 6 – A13, 7 – A15, 8 – A17. ?ieue oeeoiaaiaoe/ieo aeine?aeaeaiue o iaoieia?? na?oey i?e a?o?eoao. I?e OA anoaiiaeaii aenieo /anoioo aeyaeaiiy aioeaaio HLA A27 ? ??aeeo cono??/a?iinoue aioeaai?a A9, A7, A12, A35 ? A40 (?en. 1). Aei iaea?eueo oa?aeoa?ieo HLA-anioe?aoe?e, ui iaoiiaeai? eiia?iaoe?yie aioeaai?a eieon?a A oa/aai A, a?aeiineeeny aeyaeaiiy oaiioei?a A5,27, A7,27, A12,27, A2,A27, A10,A27, A19,A27 ? cieaeaiiy cono??/a?iino? oaiioei?a A3, AO, A7, AO, A1,A8, A2,A15, A2,A40, A3,A7. Noeoii?noue iaai?o eieon?a aioeaai?a A ? A o oai?eo ia O? aeinoaoiuei ??ciiiai?oia ? cia/ii a?ae??ciy?oueny a?ae oaei? o eiio?ie?. A?aecia/a?oueny i?aeaeuaiiy /anoioe aioeaai?a A9, A12, A35, oiae? ye aioeaaie A3, A9, A10, Aw19, A28, A5, A13, A16, A21 ?a?no?othoueny ??aea, ai?ae o iiioeyoe??. Oai?ei c o?aaeaiiyi na?oey i?eoaiaiii iin?enoai A3, A15 oa A17, aea ia oeiiai i?enooi?noue A10 (o iaioiio nooiai? oea noino?oueny A9). ?en. 2. Ei?aeyoe?ei? ca’ycee i?ae oyaee?noth o?aaeaiiy na?oey oa ?ioiieia?/ieie iieacieeaie o oai?eo ia ?A. I?ei?oea. 1 – Oe?E, 2 – ?A-I, 3 – ?A-G, 4 – IIA, 5 – OI, 6 – ?2-IA, 7 – eaoaen-oano, 8 – ?A-A, 9 – ?aaeoe?y Aaaea?-?ioca, 10 – INA, 11 – O?I, 12 – /enei A-e?ioioeeo?a, 13 – OAI, 14 – /enei O-e?ioioeeo?a, 15 – /enei O-noi?ani??a, 16 – oano c INO, 17 – ?AOE ia OAA, 18 – ?AOE ia Eii. A?oie oai?eo na?iiaaaoeaiei ?A ca aioeaaiaie eieon?a A ? A nenoaie HLA ia a?ae??ci?thoueny a?ae iiioeyoe?eiiai eiio?ieth, a i?e na?iiiceoeaiiio aa??aio? caoai?thaaiiy niinoa??aa?oueny i?aeaeuaia /anoioa aioeaaio A13. O a?oi? na?iiiceoeaieo oai?eo aeua, i?ae o iaoe??io?a c na?iiaaaoeaiei aa??aioii caoai?thaaiiy, /anoioa DR4. Aei o?aaeaiiy na?oey o oai?eo ia ?A noeeuei? iniae c aioeaaiaie DR1 ? DR3.Iin??a aioeaai?a A12, A13, DR1 oa DR3 iiaeia a?aeianoe a a?oio ?eceeo ?icaeoeo ea?ae?aeueii? iaoieia?? i?e ?A. I?e O? iaaacia/i?noue o?aaeaiiy na?oey iathoue aioeaaie A3, A15 ? A17, a i?e OA – A12. O oai?eo ia O? ?c A9 oa A10 iiaeia i?iaiicoaaoe ni?eyoeeaee ia?aa?a iaoieia?/iiai i?ioeano ii a?aeiioaiith aei ci?i c aieo na?oey. Iaaiith i??ith oea ae noino?oueny oai?eo ia OA c aioeaaiii Aw19. Ieoaiiy iaoiaaiaco ea?ae?aeueii? iaoieia?? o oai?eo ia a?o?eoe. I?iyae ea?aeeoo i?e ?A i?yii aca?iiiia’ycai? c ??aiai Oe?E, ?A-I ? ?A-G, o iaioiio nooiai? c ??aiai i?ioei?iea?ae?aeueieo aioeo?e (p<0,05), a iaa?iaii – c iieacieeaie ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a o ?AOE ia i?oiaaie (Eii, OAA) ? iaeo?io?e?a o oano? c INO (?en. 2). Ii?oieia?/i? ci?ie a ?ioiieiiiaoaioieo i?aaiao i?e aenia?eiaioaeuei?e iiaeaa?? iiaeooue a?aeia?aaeaoe nenoaii? ci?ie ?ioiiiai noooono, ui aeieeathoue aiane?aeie io?eiiaiai aeenaaeaino. No?eea aeiaaio?eaaea a?ia?o?eeai?y aeeeeea? ?ioii? ii?ooaiiy, i?i ui na?ae/aoue i?eai?/aiiy oaaioeeoa?ii? ooieoe?? iaeo?io?e?a ? iae?ioaa?a, a oaeiae aenie? oeo?e aooiaioeo?e. Iiaeia i?eionoeoe ?ioiieiiieaeniee /e aooiaioeo?eueiee oa?aeoa? o?aaeaiiy na?oey o aenia?eiaioaeueieo oaa?ei. ?en. 3. Ci?ie iieaciee?a ?ioi?oaoo o oai?eo ia iiaeaa?o (±% a?aeoeeaiue a?ae ia?aiao??a o caei?iaeo ethaeae). I?ei?oea: ? – aac o?aaeaiiy na?oey, ?? – c o?aaeaiiyi na?oey; 1 – O-e?ioioeeoe, 2 – A-e?ioioeeoe, 3 – ?AOE ia OAA, 4 – ?AOE ia Eii, 5 – ?A-G, 6 – ?A-A, 7 – ?A-I, 8 – Oe?E, 9 – aioe-iAeIE, 10 – aioe-aeAeIE, 11 – IOA, 12 – INaeA, 13 – IIA. O oai?eo ia iiaeaa?o aac ee?i?ei-?ino?oiaioaeueieo iciae na?oeaai? iaoieia?? cieaeo?oueny /enei O-e?ioioeeo?a o ia?eoa?e/i?e e?ia? ? ca?eueoothoueny oeo?e aioe-iAeIE (?en. 3). Ne?ae i?aee?aneeoe, ui oae? ?ioii? cnoae noaoenoe/ii aeinoia??ii a?ae??ciythoueny ia o?eueee a?ae aiaeia?/ieo iieaciee?a o caei?iaeo ethaeae, a e o oai?eo c ea?ae?iiao??th. A oie aea /an o oai?eo c o?aaeaiiyi na?oey ?a?no?o?oueny yaia i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? O-ee?oei o oanoao c OAA ? Eii, eio?a i?io?ea? ia oe? aenieiai ai?noo Oe?E o e?ia?, a oaeiae oeo??a aooiaioeo?e aei oeaieiieo aioeaai?a. Caaaeii, c?inoaiiy oeo??a aioeo?e aei oeiono, naeac?iee ? na?oey o oaeeo iaoee?io?a iaaaaeo? ?acoeueoaoeianoaaeaiiy oaa?ei c aenia?eiaioaeueiith a?ia?o?eeai??th. Iaea?eueo? cnoae IA-A, IA-A oa IA-F2? aeieeathoue o oai?eo c o?aaeaiiyi na?oey (?en. 4). Eiioeaio?aoe?y IA i?yii ei?aeth? ?c ai?noii o e?ia? iaeiiiaiai ae?aeueaeaa?aeo – aoi?eiiiai i?iaeoeoo IIE. ?en.4. Ai?no IA o e?ia? o caei?iaeo ethaeae ? oai?eo ia ?A aa OA (ia/ie). I?ei?oea. ? – aac o?aaeaiiy na?oey, ?? – c o?aaeaiiyi na?oey. Iae?iaiaeie?eiia ?aaoeyoe?y o cia/iiio nooiai? aecia/a? ooieoe?iiaeueiee noai na?oey o oai?eo ia a?o?eoe. Iathoue i?noea ei?aeyoe?? ia?aiao??a ei?oecieai?? c oacaie oaeaeeiai aeaiaiiy oa iii??iiai iaiiaiaiiy, o?eaaeinoth ae?anoiee oa ?iaeaenii ?icneaaethaaiiy i?iea?aeo. Iaea?eueo? ci?ie ai?iiiaeueiiai noaoono aeyaeaii i?e a?ia?eeiaoe/iiio ? (o iaioiio nooiai?) i?e a?iieeiaoe/iiio oeiao aaiiaeeiai?ee, i?e/iio cnoae ai?noo E, A ? ? iaee iaeiaeiao ni?yiiaai?noue. Iaea?eueo? ii?ooaiiy ai?iiiaeueiiai noaoono aeyaeaii o oai?eo ia ?A; aiie a iniiaiiio noinoaaeeny aeoeaiino? ? (cieaeaiiy iieaciee?a) ? A (ca?eueoaiiy). sseui o oai?eo ia iiaeaa?o aac ea?ae?iiao?? ai?no oeeo ai?iii?a o e?ia? i?aeoe/ii ia a?ae/oaaa nooo?aeo ci?i, oi o ianoaaeaieo iaoe??io?a c o?aaeaiiyi na?oey ye aeoeai?noue ?, oae ? ??aaiue A cia/ii ia?aaeuoaaee aiaeia?/i? iieacieee o caei?iaeo ethaeae. Ci?ie noaoaaeo ai?iii?a oa?aeoa?ecoaaeeny i?eai?/aiiyi i?iaeoeoe?? O ? iineeaiei neioacii I. I?e ?icaeoeo na?oeaai? iaoieia?? o oai?eo ia iiaeaa?o ??cei c?inoa? aeoeai?noue A ( o 1,5 ?ace) ? I (o 2,6 ?ace). Ia oeueiio oe? i?aeaeuo?oueny ? ai?no O o e?ia? (?en. 5). Ni?aa?aeiioaiiy O/A o iaoe??io?a aac ea?ae?iiao?? neeaaea? 50:1, a i?e o?aaeaii? na?oey – 42:1. ?en. 5. Ci?ie ai?iiiaeueiiai noaoono o /ieia?e?a, ui no?aaeaeathoue ia iiaeaa?o (±% a?aeoeeaiue a?ae iieaciee?a o caei?iaeo /ieia?e?a). I?ei?oea. ? – aac o?aaeaiiy na?oey, ?? – c o?aaeaiiyi na?oey. 24 oaa?eiai c? ooo/ii noai?aiith iiaeaa?ith oaiaeeee noaiaea?oio aeico ?ae?c?iaai?iiio (140 ia/ea iane), i?ney /iai ?a?no?oaaee aeieeath/? ci?ie eiioeaio?aoe?? E o oee?eoethth/?e e?ia?. O 1-e a?oi? (12 iniaai?a) i?ney oaaaeaiiy ai?iiio niinoa??aaee i?aeaeuaiiy ??aith E a?aeiia?aeii /a?ac 5 oaeeei ia 9,6% (p>0,05) ? /a?ac 30 oaeeei ia 27,2% (p<0,01) ii a?aeiioaiith aei aeo?aeiiai ??aith, a o 2-e a?oi? (12 oaa?ei) /a?ac 5 oaeeei ae?yeiny cieaeaiiy ??aith E (ia 6,6%, p>0,05), yea /a?ac 30
oaeeei ci?ithaaeinue eiai cia/iei i?aeaeuaiiyi (ia 73,8%, p<0,001). O oai?eo ia ?A ??ai? O3, O4 ? OOA o e?ia? i?iyaeythoue oaiaeaioe?th aei i?aeaeuaiiy, i?e/iio eiioeaio?aoe?y O4 ca?eueoo?oueny o iaoe??io?a c o?aaeaiiyi na?oey, ui ei?aeth? c? nooiaiai aeoeaiino? caoai?thaaiiy. AEiaeiee oai?ee a i?ioean? ianoaaeaiiy ia io?eioaaa aetheiei?oeei?aei? ai?iiie. I?e i?i?iaeueiiio nooiai? aeoeaiino? iaoieia?/iiai i?ioeano (A?) ??aaiue O3 o e?ia? aoa ciaioaiee, a O4 – i?aeaeuaiee. Ne?ae cacia/eoe, ui a?eueo ae?aaeai? a?aeoeeaiiy a?ae ia?aiao??a ai?iiiaeueiiai noaoono o caei?iaeo ethaeae i?e A? aeyaeeeny i?eoaiaii? oai?ei aac ea?ae?aeueii? iaoieia??. Ca c?inoaiiyi aeoeaiino? oai?iae iieacieee O3 ? O4 oaeiae cia/ii i?aeaeuoaaeeny, i?e/iio i?e A??? oea aoei o a?eueoiio nooiai? oa?aeoa?ii aeey iaoe??io?a c ea?aeeoii. I?eaeecii oae? ae aeai? iaea?aeaii ? ii a?aeiioaiith aei OOA. I?e iiaeaa?? i?aeaeuo?oueny o e?ia? ??aaiue OA ? EIAeIA, oiae? ye ai?no EIIA cieaeo?oueny. A?ae??ciyeueiith iniaeeainoth aeene?i?aeai?? o iaoe??io?a c ea?ae?aeueiith iaoieia??th aoei c?inoaiiy o e?ia? eiioeaio?aoe?? OA. sseui o a?oi? caei?iaeo ethaeae eiao?oe??io aoa?iaaiino? neeaaeaa 2,1, oi o ianoaaeaieo oai?eo aac o?aaeaiiy na?oey – 2,2, a o in?a c ea?ae?iiao??th – 2,3. Ii?iaeueiee ??aaiue e?i?ae?a o oai?eo ia iiaeaa?o aac o?aaeaiiy na?oey eiinoaoiaaii o 6 ?ac?a ??aea, i?ae c ?icaeoeii ea?ae?iiao??. Inoaiiy noi?iaiaeaeoaaeanue ca?eueoaiiyi ???, ?V ? iniaeeai ??A oaiioei?a a?ia?e?i?aeai??. I?e IA /eieoueny aeoeaaoe?y i?iaeoeo?a IIE ? i?eai?/aiiy aioeieneaeaioieo nenoai, i?e/iio oea noino?oueny aeeeth/ii oai?eo c ea?ae?aeueiith iaoieia??th. Oaeoe/ii ae?aaeai? cnoae IIE anioe?ththoueny c ?icaeoeii ci?i n aieo na?oey. Iieacieee aeeiai?/iiai II ne?iaaoee e?ia? i?e ?A ?noioii ia?aaeuothaaee aiaeia?/i? o eiio?ie?, i?e/iio cia/aiiy II1, II2 ? II3 >M+3m caei?iaeo
ethaeae aeyaeaii a?aeiia?aeii o 76,7%, 62,8% ? 67,4% ianoaaeaieo
iaoe??io?a. Ne?ae a?aecia/eoe, ui ia?aiao?e EIE e?ia? oai?eo 0,05).

sseui ii??aiyoe i?ae niaith a?oie uo??a, ye? a?ae??ciyeeny iieacieeaie
aeaeo?e/ii? noaa?eueiino? na?oey, oi uiaei nainiiioi?ii? ei?e ?
a?iieaiio ?iciiae?e aeoeaiino? aeine?aeaeaieo oa?iaio?a aoa ianooiiei:
5I o 1 a?.>2 a?., oiae? ye AAeA – o 1 a?.=2 a?. Aeoeai?noue 5I
aeyaeeanue iaea?eueo aenieith naia o 1-e a?oi? ? nyaaea 10,1±0,76 iiieue
?i/oa ia a?eeo. O 3-e (eiio?ieuei?e) a?oi? aioo??oiueii’ycaaa oaaaeaiiy
ianea ia /eieei aoaeue-yeiai ?noioiiai aieeao ia ??aaiue oeeee?/ieo
ioeeaioeae?a o no?oeoo?ao aieiaiiai iiceo. Ai?no oeAIO ? oeAIO o
nainiiioi?i?e ei??, a?iioaeaion? ? a?iieaii? ciaoiaeeany o iaaeao
cia/aiue ?ioaeoieo oaa?ei. O 4-e (ae?oa?e eiio?ieuei?e) a?oi? i?ney
oaaaeaiiy AeIEA aeyaeaii caaaeueio caeiiii??i?noue ci?i oeeee?/ieo
ioeeaioeae?a aeey nainiiioi?ii? ei?e ? a?iieaiio, eio?a i?noeoueny o
oiio, ui i?ioyaii 1 aiaeeie ae?yeinue cieaeaiiy ??aith oeAIO ?
ca?eueoaiiy oeAIO, yea /a?ac 6 aiaeei ci?ithaaeinue ?o ?iaa?n??th.
Iaea?eueo ae?aaeai? ci?ie noinoaaeeny a?iieaiio, aea ??aaiue oeAIO /a?ac
1 aiaeeio nyaaa 62,2% ? oeAIO – 242,0% aeo?aeieo cia/aiue. A
a?iioaeaion? niinoa??aaee ia?aeaeueia i?aeaeuaiiy ??aiae oeAIO oa oeAIO
i?ioyaii 1 aiaeeie (a?aeiia?aeii ia 35,5%, p<0,001 ? 22,5%, p>0,05) ? ?o
??ciini?yiiaaio aeeiai?eo o ianooiiiio. *a?ac 6 aiaeei iaeneiaeueiee
nooi?iue ae?aaeaiino? oeAIO iaa i?noea o nainiiioi?i?e ei?? (217,0% o
ii??aiyii? c eiai ??aiai aei oaaaeaiiy AeIEA), naia ooo a?aecia/aee ?
iaea?eueo iecueeee ??aaiue oeAIO o ii??aiyii? c a?iieaiiii ?
a?iioaeaionii. I?i?iaeueio ?aaeoe?th oeAIO aeyaeaii o a?iioaeaion?
(68,5% a?ae aeo?aeieo aeaieo; aeey ii??aiyiiy o a?iieaii? – 131,2%).

E?eoaaiiy iaoieia?? na?oey i?e a?o?eoao. Anoaiiaeaii iiceoeaio
aeeiai?eo iieaciee?a AoiEA o oai?eo ia ?A e IA o i?ioean? e?eoaaiiy
aiaeai?eeaie ii 10-20 ia/aeia. I?aeaeuaiiy aeiaaeueii? nei?i/oaaeueii?
caeaoiino? i?iea?aeo e?aiai oeoii/eo i?ae aieeaii aeaioeaeaeiaai?
oa?ai?? ?AIO iaoiiaeaii cieaeaiiyi ia?aaaaeii iinoiaaaioaaeaiiy ca
?aooiie aaciae?eaoaoe?eii? ae??. I?e iiaeaa?? niinoa??aa?oueny iacia/ia
i?aeaeuaiiy aeoeaiino? C ieacie ? cieaeaiiy eiioeaio?aoe?? A.
I?aee?aneei, ui oe? i?aia?aoe /eiyoue a?iio?eeai?/io (o?eeico??/io)
ae?th.

Ne?ae cacia/eoe, ui i?e caiaeueieo caoai?thaaiiyo noaeia?a AE iieacaie
i?aeoe/ii o an?o iaoe??io?a, iacaeaaeii a?ae iayaiino? /e a?aenooiino?
ea?ae?aeueii? iaoieia??, ai aeeeeeathoue /?oeo a?oa??iey?io
aaciae?eaoaoe?th, a aacieiino??eoe?y i?eoaiaiia oaeei oai?ei. AA o
oai?eo ia a?o?eoe iineaaeththoue ciaaiethth/ee e i?ioecaiaeueiee aoaeoe
IICI, a /anoi-aonoi aeeeeeathoue ? a?ia?o?eeai?th, ui caaaaeaa ?o
aeei?enoaiith i?e IA ? aeiaaa? a?aeiia?aeiiai eiio?ieth ??ith NE o
e?ia?.

Caaaeueiia?aeiia oa?ai?y iiaeaa?e ni?eyea ciaioaiith o e?ia? o?eueee
eiioeaio?aoe?e NE ? EI, oiae? ye i?e?aeiaiiy aei eiiieaeno e?eoaaeueieo
caoiae?a aiaaiceio (aei 18 ae?/aeia) noi?iaiaeaeoaaeinue i?eai?/aiiyi
ii/aoeiai i?aeaeuaiiai ai?noo II, 5I ? AAeA. Ci?ie aeoeaiino? oa?iaio?a
io?eiiaiai iai?io ia oe? nenoaiii? aiceiioa?ai?? /eieeeny ia?aeaeueii
a?aeiiaethaaiith ??aiae iiia?aaeiee?a iaoaaie?cio io?ei?a – ae?oe?io,
aethoai?io e ania?aaeiiai? eeneioe. Aiaaiceiioa?ai?y caeaoia iiceoeaii
aieeaaoe iaeii/anii ? ia noaeiaiaee, ? ia ea?ae?aeueiee i?ioean o oai?eo
ia a?o?eoe, ae?th/e i?ioecaiaeueiee, ciaaiethth/ee, ?ioiiiiaeoethth/ee,
aioeieneaeaioiee, a?iie?i?aeai?/iee oa ?io? iiceoeai? aoaeoe.

Ie aeei?enoiaoaaee e?iaii? ii 100 ia/aeia i?ioyaii 3 i?nyoe?a o oai?eo
ia iiaeaa?o. E?iaii? aoaeoeaai i?e an?o oeiao a?ia?e?i?aeai?? ? ?
i?aia?aoii ia?oiai ?yaeo aeey e?eoaaiiy a?ia?o?eae?oea?eaeai?? ia
o?eueee o oai?eo ia IA, a e i?e ?ioeo caoai?thaaiiyo noaeia?a.
I?e?i?iiciaaiee oaiio?a?ao e?iaio?e 200I (i?ioeaoioai) i?iiiio?oueny
aeey e?eoaaiiy oai?ia noaeia?a c o?aaeaiiyi na?oey ye c?o/iee o
aeei?enoaii? (iaeii?aciaee uiaeaiiee i?eeii), aacia/iee ? aoaeoeaiee
a?iie?i?aeai?/iee i?aia?ao. E?iaio?e /eiea oaeiae ae?aaeaio
a?iio?eeai?/io (o?eeico??/io) ae?th, oiio a?i iaeaaeeoue aei i?aia?ao?a
aea??o i?e iiaeaa?? c o?aaeaiiyi na?oey.

Aea/aii aeeiai?eo ii?oieia?/ieo ci?i o na?oe? i?e aenia?eiaioaeuei?e
iiaeaa?? i?ney i?ecia/aiiy aeiio?eiieo. A oiiaao ao??iiai ia?eico oeyoii
aeaeai?oaoe?? /a?ac 4 oeaeaei? /anoeo oaa?ei aeaiaeeee c aenia?eiaioo
(1-a a?oia), a ?ioei (2-a a?oia) ia oe? a?ia?o?eeai?/iiai ?aoe?iio ca
aeiiiiiaith niaoe?aeueiiai ciiaeo o oeoiie oaiaeeee aeiio?eiie (25
ia/ea/aeia). Oaeee aenia?eiaio o?eaaany ua i?nyoeue. O i?ioean?
e?eoaaiiy oaa?ei aeiio?eiieii eiinoaoiaaii ciaioaiiy oiaueie no?iee
a?oa??e ? a?oa??ie, a?ia?ieac?? i’ycaaeo aieieii, ?o ieaciaoe/iiai
i?iniieooaaiiy, i?ie?oa?aoe?? aiaeioae?th. Iaea?eueo nooo?ai
i?eai?/oaaeany ia?eaaneoey?ia ?io?eueo?aoe?y. Anoaiiaeaii cieaeaiiy
aeeno?io?/ieo ci?i i?iea?ae?ioeeo?a, a oaeiae o?aaiaioaoe?? i’yca?eo
aieieii.

Oai?ei c iiaeaa?ith aeiio?eiie i?ecia/aee o aeic? 300-600 ia/aeia ?
aeei?enoiaoaaee eiai aac aoaeue-yeeo ea?ae?io?iiieo cania?a. *a?ac 3-4
oeaeaei? ia oe? aeiio?eiieoa?ai?? o 14% oai?eo cieeea ia?aooeaaa
a?eoi?y, o 33% — aeno?anenoie?/ia a?eoi?y, o 18% — ae?anoie?/ia
aeenooieoe?y e?aiai oeoii/ea, o 33% — ca?eueoaeany o?aeoe?y aeeeaeo
e?ia?. I?ae aieeaii aeiio?eiieo ciaioeany ??aaiue o e?ia? NE ? EI,
cia/ii iie?aueany noai IIE (?en.6).

?en. 6. Aeeiai?ea iieaciee?a io?eiiaiai e e?i?aeiiai iai?i?a, IIE oa
ai?iiiaeueiiai noooono a i?ioean? e?eoaaiiy oai?eo ia iiaeaa?o
aeiio?eiieii

(±% a?aeoeeaiue a?ae ia?aiao??a o caei?iaeo ethaeae).

O oai?eo c na?iiiceoeaiei aa??aioii ?A i?iaaaeaii ieaciaoa?ac (5
iaoe??ioai) ? aaiini?aoe?th (6). Eiio?ieueia a?oia iaei a?ae??ciyeany
a?ae iniiaii? (c o?aaeaiiyi na?oey) ca aeiaaio?eaaeinoth caoai?thaaiiy,
noaae??th ?A ? nooiaiai aeoeaiino? iaoieia?/iiai i?ioeano. Ia oe?
aeno?aei?ii?aeueiiai i/euaiiy e?ia? o iaei??? oai?i? c ia?aooeaaith
a?eoi??th a?aeiiaeany neioniaee ?eoi, ua o iaei??? c aeaio iaoe??ioie
cieeea AEIIA. E?ioeaaee nenoie?/iee ?ici?? e?aiai oeoii/ea i?ney
aoa?aioii? oa?ai?? o iniiai?e a?oi? ca?eueoeany c 2,4±0,12 ni aei
3,0±0,11 ni (p<0,01), a e?ioeaaee nenoie?/iee ia’?i – c 21,9±1,39 ie aei 34,8±1,94 ie (p<0,005). Eiinoaoiaaii i?aeaeuaiiy o?aeoe?? aeeeaeo e?ia?, oi/a noaoenoe/ii iaaeinoia??ia (a?aeiia?aeii 69,5±2,07% aei e?eoaaiiy ? 74,0±2,55% i?ney e?eoaaiiy). ?ic?iaeaii ianooiio iaaee/io oaoiieia?th e?eoaaiiy oai?eo ia a?o?eoe c o?aaeaiiyi na?oey. I?e aenieiio nooiaith aeoeaiino? caoai?thaaiiy c ?icaeoeii i?iea?aeeo?a ? i?e a?aenooiino? aoaeoo iaaeeeaiaioicii? oa?ai?? ia iiia?aaei?o aoaiao e?eoaaiiy ne?ae ii/eiaoe e?eoaaiiy c aoa?aioieo aeno?aei?ii?aeueieo iaoiae?a (aaiini?aoe??, ieaciaoa?aco). O iiaeaeueoiio an?i oai?ei, iacaeaaeii a?ae iicieia?/ii? oi?ie, nooiaith aeoeaiino? ? iayaiino? oeo /e ?ioeo a?noea?eo?a, aeioe?eueii i?e?aeiaiiy aacenii? nenoaiii? aiceiii? oa?ai?? i?ioyaii aeaio ? a?eueoa i?nyoe?a (iai?eeeaae, aiaaiceio aai oeiaaiceio, ui /eiyoue i?ioecaiaeueio, i?ioeiaa?yeiao, ?ioiiiiaeoethth/o, ciaaiethth/o, a?iie?i?aeai?/io ? aioeieneaeaioio ae?th). Iayai?noue a?ia?o?eeai?? i?e oai?iaao noaeia?a aeiaaa? i?ecia/aiiy aeiio?eiieo (i?eo??oo, oeeei??eo, oeeeii?eio), ae?y yeeo iioaioeo?oueny ia?aeaeueiei aeei?enoaiiyi aiaaiceio. ?ia?a?oi?e EI i?e caiaeueieo oai?iaao noaeia?a aieiae?thoue ia eeoa o?eeiaeai?aneaiei aoaeoii, a e aioeieneaeaioiei. ?icaeoie a?ia?e?i?aeai?? (a?ia?oieanoa?eiai??, a?ia?o?eae?oea?eaeai??, i?aeaeuaiiy EIIA ? EIAeIA) aeeeoo? iaiao?aei?noue i?ecia/aiiy e?iaii?o /e e?iaioeeo. I?e ae?aaeaieo ?ioiieo ?iceaaeao, eiee eii/a iio??aii i?iaaaeaiiy ?ioiiiiaeoeyoe??, nii/aoeo iieacaii eo?niaa e?eoaaiiy oeiae?iii, a aaea iio?i ia?a?aoiaaieie a?iie?i?aeai?/ieie i?aia?aoaie. Aeei?enoaiiy e?iaii?o ? e?iaioeeo iiaeeeai aeoaea o?eaaeee /an, aea aaea ii cae?i/aiith nenoaiii? aiceiioa?ai??. Oai?ei c? noiaaiith nenoie?/iith oa ae?anoie?/iith aeenooieoe??th e?aiai oeoii/ea iaiao?aeii i?ecia/aiiy ?AIO, a i?e aacneiioiii?e o?eueee aeeanoie?/i?e aeenooieoe?? iiaeooue aeei?enoaoeny AE. Inoaii? ne?ae i?ecia/aoe oai?eo c ia?aooeaaith a?eoi??th. Nenoie?/ia aeenooieoe?y e?aiai oeoii/ea c iayai?noth ea?ae?aeueii? iaaeinoaoiino? aeiaaa? i?aeeeth/aiiy na?oeaaeo ae?eiceae?a, a nenoie?/ia ? ae?anoie?/ia aeenooieoe?y o oaeeo oai?eo – ae?o?aoee?a. O?aaa iai’yoaoe, ui oai?ei c IA i?ecia/aiiy naeo?aoee?a i?ioeiieacaii (a?ia?o?eeai?/iee aoaeo). Oaaeeoey Aoaeoeai?noue e?eoaaiiy oai?eo ??cieo a?oi Aoaeoeai?noue e?eoaaiiy A?oie oai?eo Anueiai (n=180) oniiaia (n=53) eiio?ieueia (n=127) Cia/ia iie?ioaiiy Iie?ioaiiy Aac aeeiai?ee Iia??oaiiy 9 (17,0%) 33 (62,3%) 11 (20,8%) - 2 (1,6%) 91 (71,7%) 31 (24,4%) 3 (2,4%) 11 (6,1%) 124 (68,9%) 42 (23,3%) 3 (1,7%) A?aoiaoth/e ?ic?iaeaio oaoiieia?th aoei i?ie?eiaaii 53 oai?eo c caiaeueieie caoai?thaaiiyie noaeia?a (1-a, iniiaia a?oia). 127 iaoe??io?a, eio?eo e?eoaaee caaaeueiiaeciaieie caniaaie, neeaee 2-o (eiio?ieueio) a?oio. Iaeaea? a?oie ia a?ae??ciyeeny i?ae niaith ca iicieia?/ieie oi?iaie a?o?eo?a, aa??aioaie o?aaeaiiy na?oey, noaooth, a?eii, aeiaaio?eaaeinoth caoai?thaaiiy, nooiaiai aeoeaiino? iaoieia?/iiai i?ioeano, iaoiaeaie e?eoaaiiy ia iiia?aaei?o aoaiao. Iieacieee ?2 neeaee a?ae 0,11 aei 2,68 (p>0,05). A?aoiaoth/e
caaaeuei?noue ee?i?/ii? ea?oeie ? iaoiaaiaco o?aaeaiiy na?oey i?e
caiaeueieo oai?iaao noaeia?a on?o oaeeo oai?eo ia’?aeiaee o iaeio
iniiaio a?oio. O ?ic?iaeo ia aoei aeeth/aii iaoe??io?a c aaaeaie na?oey
? ia?eea?aeeoii.

Ioe?ieo aoaeoeaiino? i?iaaaeaii iacaeaaeieie aenia?oaie
(ni?a?ia?oieeaie Aeiiaoeueeiai iaeaniiai ?aaiaoieia?/iiai oeaio?o). I?e
ioe?ioe? aoaeoeaiino? e?eoaaiiy ei?enooaaeeny ianooiieie ia?aiao?aie.
I?ae “cia/iei iie?ioaiiyi” ?icoi?ee cieeiaiiy nea?a c aieo na?oey,
a?aeiiaeaiiy ia?aiao??a nenoie?/ii? ? ae?anoie?/ii? ooieoe?? e?aiai
oeoii/ea, ii?iae?caoe?th na?oeaaiai ?eoio. Iia??oaiiy aeo?aeieo
ia?aiao??a AoiEA, iiyao aeieaae, ia?aooeaai? oa aeno?anenoie?/ii?
a?eoi?? ?icoe?ithaaee ye “iia??oaiiy”, iacaeaaeii a?ae noa’?eoeaiiai
a?ae/oooy oai?iai. ?acoeueoaoe e?eoaaiiy ioe?ithaaee /a?ac 8-18 i?nyoe?a
a?ae eiai ii/aoeo (oaaeeoey).

Aeia?a aoaeoeai?noue e?eoaaiiy nyaaea o 79,3% oai?eo 1-e ? 73,3% oai?eo
2-? a?oie (?2=0,74, p>0,05). I?ae oei “cia/ia iie?auaiiy” eiinoaoiaaii o
iaoe??io?a iniiaii? a?oie cia/ii /ano?oa (?2=13,42, p<0,001). sseui aac?acoeueoaoiei e?eoaaiiy o 1-e a?oi? a?aecia/aii o 20,8% ianoaaeaieo in?a, oi o 2-e a?oi? – o 26,8%, i?e/iio o?eueee a eiio?ie? anoaiiaeaii iia??oaiiy ia?aa?ao iaoieia?/iiai i?ioeano. A oe?eiio, a?aei?iiino? o aoaeoeaiino? cai?iiiiiaaieo ? caaaeueiia?aeiieo e?eoaaeueieo caoiae?a neeaee ?2=14,77, p<0,001. AENIIAEE: 1. O?aaeaiiy na?oey i?e caiaeueieo caoai?thaaiiyo noaeia?a iaeaaeeoue aei iaea?eueo /anoeo a?noea?eo?a ? aaaaoi a /iio aecia/a?oueny oa?aeoa?ii ia?aa?ao noaeiaiaiai neiae?iio. ?icaeoie ea?ae?iiao?? /ano?oa a?aei?/a?oueny o oai?eo ia ?A c ooyaoaaiiyi o iaoieia?/iee i?ioean na?aaei?o e e?oiieo noaeia?a, i?e OA – c iayai?noth nae?i?ea?oo, i?e O? – c a?o?eoii e?eaeicaeooaeiieo noaeia?a ? noaeia?a ?oe. Iayai?noue ea?ae?iiao?? anioe?th?oueny c a?eueo oyaeeei ee?i?ei-?aioaaiieia?/iei ia?aa?aii oai?ia iii?ii-?ooiaiai aia?aoo, a oie, a naith /a?ao, ? a?aeia?aaeaiiyi aaaeeino? o?aaeaiiy na?oey. 2. I?e a?o?eoao iacaeaaeii a?ae iicieia?? o?aaeathoueny i?iea?ae, ia?eea?ae ? aiaeiea?ae (c oi?ioaaiiyi aaae na?oey), aeieeathoue ii?ooaiiy ?eoio ? i?ia?aeiino?, ?aii oi?iothoueny ei?iia?iea?ae?ineea?ic, ui aeey ?aiiuei? ae?aaiinoeee ea?ae?iiao?? iio?aao? i?iaaaeaiiy o oai?eo eiiieaeniiai ianoaaeaiiy c aeeiiaiiyi AEA, ooieoe?iiaeueieo oa?iaeieia?/ieo i?ia, *NAN, OEI, AoiEA, ?A, a i?e iaiao?aeiino? e AOAe na?oey. 3. Ii?oieia?/ia ea?oeia na?oey i?e caiaeueieo oai?iaao noaeia?a aaeueie ??ciiiai?oia, i?e/iio ? ye caaaeuei?, oae ? niaoeeo?/i? aeey oiai /e ?ioiai caoai?thaaiiy ci?ie, ui iaoiiaeai? ?nioth/eie ?ioiieie oa iaoaaie?/ieie ?iceaaeaie. 4. Iaoiaaiac ea?ae?aeueii? iaoieia?? i?e a?o?eoao o?nii iia’ycaiee c ?ioiieie ii?ooaiiyie, i?i ui na?ae/aoue aeenaaeain iniiaieo eean?a ?ioiioeeo?a, cieaeaiiy ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a ? iie?ii?oiiioeeaa?ieo iaeo?io?e?a, a?ia?i?iaeoeoe?y ??cieo aooiaioeo?e. Oyaee?noue ci?i ?ioiieia?/ieo iieaciee?a ei?aeth? c? nooiaiai aeoeaiino? a?o?eo?a ? aecia/a? oa?aeoa? ea?ae?aeueiiai neiae?iio. ?ioii? oaeoi?e aa?ooue o/anoue o ?icaeoeo ia eeoa o?aaeaiiy na?oey i?e ?A, O? ? OA, a e i?e iiaeaa??, ui aeiaaaeaii ye ee?i?/ieie, oae ? aenia?eiaioaeueieie aeine?aeaeaiiyie c aea/aiiyi o oaa?ei no?oeoo? ?ioiieiiiaoaioieo i?aai?a ? noaio ?ioi?oaoo. 5. I?e aenia?eiaioaeuei?e iiaeaa?e/i?e ea?ae?iiao?? ae??oueny ii?ooaiiy aeaeo?e/ii? noaa?eueiino? na?oey, a aiane?aeie a?ia?o?eeai?? ci?ith?oueny aeoeai?noue oa?iaio?a io?eiiaiai iai?io a no?oeoo?ao aieiaiiai iiceo ? iia??oothoueny ?aca?ai? iiaeeeaino? iaoaaie?cio aaeaiiceio o nainiiioi?i?e ei??, a?iioaeaion?, a?iieaii?. 6. O ?icaeoeo iaoieia?? na?oey i?e caiaeueieo caoai?thaaiiyo noaeia?a aeieeathoue aeenai?iiiaeuei? ii?ooaiiy ?c ci?iaie aaeaino noaoaaeo, aiiaaeio?iiieo, oe?ai?aeieo, aetheiei?oeei?aeieo ai?iii?a ? ai?iii?a ?aiei-aia?ioaicei-aeueaeinoa?iiiai? nenoaie, eio?? aecia/athoue oa?aeoa? ia?aa?ao ea?ae?iiao??. 7. Iacaeaaeii a?ae iicieia?/ii? oi?ie a?o?eo?a ?icaeaathoueny nooo?a? ci?ie io?eiiaiai e e?i?aeiiai iai?i?a ?c aeoeaaoe??th i?ioean?a IIE ? i?eai?/aiiyi aioeieneaeaioieo nenoai, ui ei?aeth? c oa?aeoa?ii ? oyaeeinoth ia?aa?ao iaoieia?? na?oey. 8. Oi/a aianie aeayeeo HLA aei noeeueiino? ?A, O? ? OA aeinoaoiuei aenieee, a?aeiiniee ?ecee aeieeiaiiy iaoieia?? na?oey i?e oaeeo caoai?thaaiiyo aecia/athoue cian?i ?io? aioeaaie, ye? u?eueii iia’ycai? c ?icaeoeii ? ia?aeiieo oai?ia na?oey. Oea aeicaiey? o naiiio aeaatho? a?o?eoa i?iaiicoaaoe a??ia?aei?noue iiyae ia ianooiieo aoaiao ea?ae?iiao??. 9. Aeieeiaiiy iaoieia?? na?oey i?e a?o?eoao aaaea aei iiyae ea?ae?iaeai?aneaiiai oaeoi?o o e?ia?, i?e/iio o?aeoe?y ne?iaaoee oai?eo c ??cieie caoai?thaaiiyie /eieoue i?e ?cieueiaaiiio na?oe? oaa?ei ia iaeiioeiiao (/anoi-aonoi ??ciini?yiiaaio) ae?th ia noai aaiiaeeiai?ee. 10. Ci?ie ai?noo a?ee?a e e?i?ae?a o e?ia? i?e caiaeueieo oai?iaao noaeia?a i?ecaiaeyoue aei ii?ooaiiy ye?niiai ? e?euee?niiai neeaaeo no?oaeoaio?a ? iiaa?oiaai-?iaeoeaieo ?a/iaei, ui a?aeia?aaea?oueny ia noai? aeeiai?/iiai II ne?iaaoee e?ia?. Ia?aiao?e i?aeoacii? oaic?iiao??? a?aeaeca?eaeththoue iayai?noue o?aaeaiiy na?oey ? a ?ioaa?aeueiiio aeaeyae? iiaeooue aooe e?eoa??yie aoaeoeaiino? e?eoaaiiy oaei? eaoaai??? oai?eo. 11. Iaa?oioiaaii aeei?enoaiiy o e?eoaaii? ea?ae?aeueii? iaoieia?? i?e a?o?eoao ieaciaoa?aco ? aaiini?aoe?? c ianooiiei i?iaaaeaiiyi nenoaiii? aiceiioa?ai??. Ii?ooaiiy io?eiiaiai iai?io aeiaaathoue i?ecia/aiiy o?eeiaeai?aneaieo i?aia?ao?a, a aee?iaiai – a?iie?i?aeai?/ieo cania?a. Iciaee iaa?oue noiaaii? aeenooieoe?? e?aiai oeoii/ea aeeeoothoue iaaaeueio iio?aao aeei?enoaiiy o oaeeo oai?eo ?AIO oa AE. ?iaeea?aeoaeueia iaoiaaiaoe/ia e?eoaaiiy oai?eo c iaoieia??th na?oey aeicaiey? cia/ii iie?aueoe aoaeoeai?noue e?eoaaeueieo caoiae?a. NIENIE IAOEIAEO ?IA?O, UI IIOAE?EIAAII CA OAIITH AeENA?OAOe?? 1. A.E.A?eiue. Iaoieiaey na?aeoea i?e a?o?eoao.-Aeiiaoee: EEOEN, 1998.-324n. (16 ?icae?e?a). 2. Eacaeia A.I., Neiy/aiei I.A., A?iieaaaa I.A., A?eiue A.E. Aeeiaie/aneia iiaa?oiinoiia iaoyaeaiea e?iae e ii/e i?e ainiaeeoaeueii-aeaaaia?aoeaiuo caaieaaaieyo nonoaaia // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu.-1996.-O.5, ?2.-N.123-125. 3. A?eiue A.E. Ee?i?ei-aenia?eiaioaeueia aea/aiiy aoaeoeaiino? aeiio?eiieo a e?eoaaii? o?aaeaiue na?oey o oai?eo ia iiaeaa?o // E?ee.-1997.-?3.-N.35-37. 4. Neiy/aiei I.A., sseoaaiei A.Ae., Iioaiia TH.A., A?eiue A.E., Anoaoia A.E., Eaiaoaiei O.N. Ea?aeeiaeai?anneaiue oaeoi? a e?iae i?e caaieaaaieyo na?aeoea // Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.-1997.-?3.-N.55-59. 5. Neiy/aiei I.A., Iioaiia TH.A., A?eiue A.E. Eniieueciaaiea yaeieoa i?e aeia?oiie/aneie aieacie: Eeeie/aneay yooaeoeaiinoue e iaoaieciu aeaenoaey // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu.-1997.-O.6, ?1.-N.21-23. 6. Neiy/aiei I.A., Aa?eiia Y.O., A?eiue A.E., Ao?oeaaa E.A., Aaneeaiei E.A. Iaoieiaey na?aeoea i?e iiaeaa?a: Eeeie/aneia eco/aiea // Ea?aeeieiaey.-1997.-O.37, ?10.-N.49-51. 7. Neiy/aiei I.A., Aa?eiia Y.O., A?eiue A.E., I?ioianeay A.A., Ieeieaiei TH.E., Aaneeaiei E.A. Iaoieiaey na?aeoea i?e iiaeaa?a: Yenia?eiaioaeueiia eco/aiea // Ea?aeeieiaey.-1997.-O.37, ?11.-N.41-43. 8. Neiy/aiei I.A., Aeue-Oaaaaeao I.I., A?eiue A.E. Neiae?ii a?aaee-oaoeea?aeee: Eciaiaiey aaiiaeeiaieee e yeaeo?ioeceieiae/aneiai noaoona a i?ioeanna ?acee/iuo iaoiaeia ea/aiey // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu.-1998.-O.7, ?1.-N.35-41. 9. Eiaaeaiei A.I., Neiy/aiei I.A., Eaiaoaiei A.A., Oa?cia A.E., A?eiue A.E., Eaooeeia A.I. Nenoaiiay yiceiioa?aiey iiaeaa?u // Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.-1998.-?1.-N.53-56. 10. Aa?eiia Y.O., A?eiue A.E., Neiy/aiei I.A., Aiiaea?aiei I.I. Aeeyiea ia ooieoeeth na?aeoea eciaiaiee iaoaaieecia aaeaiiceia a no?oeoo?ao aieiaiiai iicaa e?un i?e iiaeaee?iaaiee aeia?o?eeaiee // Iaoieiae/aneay oeceieiaey e yenia?eiaioaeueiay oa?aiey.-1998.-?2.-N.23-26. 11. Neiy/aiei I.A., Eacaeia A.I., Oaeia?iai A.A., A?iieaaaa I.A., A?eiue A.E., Neaei?aiei E.A. Eciaiaiey aeeiaie/aneiai iiaa?oiinoiiai iaoyaeaiey e?iae e ii/e i?e ?acaeoee aenoea?eoia o aieueiuo ?aaiaoieaeiui a?o?eoii // A?a/aaiia aeaei.-1998.-?7.-N.59-61. 12. A?eiue A.E. Acaeiinaycue ii?aaeaiee nonoaaia e na?aeoea i?e ?aaiaoieaeiii a?o?eoa // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu.-1999.-O.8, ?1.-N.107-109. 13. Neiy/aiei I.A., Eaiaoaiei A.A., Caeeoianeay E.E., Aa?eiia Y.O., Aioiiia A.A., A?eiue A.E. Yieaeaieieiae/aneia enneaaeiaaiea aieaciae nonoaaia o ai?ii?aai/eo oaieueiuo oaoo // Aanoiee aeaeaiu e yieaeaieieiaee.-1999.-O.3, ?1.-N. 14. Grin V.K. Echocardiographic examination in inflammatory articular diseases // School Fundam. Med. J.-1997.-Vol.3, N2.-P.74-75. 15. Sinyachenko O.V., Ignatenko T.S., Potapov Yu.A., Grin V.K., Astakhov A.L. A correlation between echocardiographic readings and blood cardiodepressive factor in various diseases // School Fundam. Med. J.-1997.-Vol.3, N2.-P.81. 16. Neiy/aiei I.A., Neaei?aiei ?.I., Oaeaea?iei TH.I., A?eiue A.E., ?aoae?ia ?.Ae. Aeeiai?/ia i?aeoacia oaic?iiao??y a?ieia?/ieo ??aeei caei?iaeo ethaeae // O?c?ieia?/iee aeo?iae.-1998.-O.44, ?3.-N.335-336. 17. A.O.Aa?eiia, Neiy/aiei I.A., A?eiue A.E., Aiiaea?aiei I.I., Aa?eiiaa I.A. Noai oeaio?aeueieo iaoai?ci?a ?aaoeyoe?? e?iaiia?ao i?e a?ia?o?eeai?? // O?c?ieia?/iee aeo?iae.-1999.-O.45, ?1-2.-N.87-96. 18. Neiy/aiei I.A., ??iiea?aa I.A., Eacaeia A.I., ?aiaoaiei A.A., A?eiue A.E., Eaooeeia I.I. Ae?aaiinoe/ia cia/aiiy aea/aiiy aeeiai?/iiai iiaa?oiaaiai iaoyao a?ieia?/ieo ??aeei a ee?i?/i?e i?aeoeoe? // Ee?i?/ia oa?iaeieia?y, o?c?ieia?y, a?io?i?y.-1998.-?1.-N.211-214. 19. A?eiue A.E. Eciaiaiey na?aeoea i?e ainiaeeoaeueiuo caaieaaaieyo nonoaaia ii aeaiiui yeaeo?i- e yoiea?aeeia?aoee // Cae?aaiio?aiaiea Aeiiaanna.-1997.-O.2, ?1.-N.18-22. 20. Aa?eiia A.O., A?eiue A.E., Neiy/aiei I.A. Niin?a i?iaiicoaaiiy ii?ooaiue oeaio?aeueieo iaoai?ci?a ?aaoeyoe?? aiiaaeio?iiioeeo?a a?iio?co i?e a?ia?o?eeai?? // Iaoaio ia aeiao?ae.-?20885 A, Oe?a?ia.-?96124803, 07.10.97. 21. A?eiue A.E. Iaoieiaey na?aeoea i?e aieacie ?aeoa?a // Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu.-1998.-O2, ?2.-N.28-32. 22. A?eiue A.E. Ia?ooaiey eeieaeiiai iaiaia e ia?aeeniiai ieeneaiey eeieaeia o aieueiuo a?o?eoaie n ii?aaeaieai na?aeoea e iooe eo ei??aeoeee // Aeooaeuei? ieoaiiy iaaeaaiaeee, aenia?eiaioaeueii? oa ee?i?/ii? iaaeeoeeie: ?anioae?eainueea ca??ea iaoeiaeo i?aoeue.-Aeiiaoeuee.-1997.-N.95-99. 23. A?eiue A.E. Eciaiaiey na?aeoea i?e iiaeaa?a (ii aeaiiui yoiea?aeeia?aoe/aneiai e ii?oieiae/aneiai enneaaeiaaiee) // Iaoa??aee tha?eaeii? iaoeiai-i?aeoe/ii? eiioa?aioe?? “Aeooaeuei? i?iaeaie aioo??oiuei? iaoieia?? oa i?neyaeeieiiii? i?aeaioiaee e?ea??a-oa?aiaao?a”.-Ee?a.-1996.-N.114-117. 24. A?eiue A.E. Ii?aaeaiea na?aeoea i?e eaea?noaaiiie oa?aiee ainiaeeoaeueiuo caaieaaaieyo nonoaaia // Oace aeiiia?aeae iaoeiai-i?aeoe/ii? eiioa?aioe?? ?aaiaoieia?a Oe?a?ie “No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”.-Aeiiaoeuee.-1996.-N.13-14. 25. I?ioianueea I.A., A?eiue A.E., Aaneeaiei ?.A. Ee?i?ei-aenia?eiaioaeueia aeine?aeaeaiiy iiaeaa?e/ii? ea?ae?iiao?? oa iaa?oiooaaiiy iaoiaaiaoe/ii? oa?ai?? // Oace aeiiia?aeae iaoeiai-i?aeoe/ii? eiioa?aioe?? ?aaiaoieia?a Oe?a?ie “No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”.-Aeiiaoeuee.-1996.-N.44-45. 26. ?aiaoaiei O.N., Iioaiia TH.I., Oa??iai I.A., A?eiue A.E., Neiy/aiei I.A. Aeine?aeaeaiiy ea?ae?iaeai?aneaiiai oaeoi?o a e?ia? i?e ?aaiaoe/ieo caoai?thaaiiyo // Iaoa??aee iaoeiaeo i?aoeue 2-ai Iaoe?iiaeueiiai eiia?ano ?aaiaoieia?a Oe?a?ie.-Ee?a.-1997.-N.14. 27. A?eiue A.E. Aca?iica’ycie o?aaeaiue noaeia?a oa na?oey o oai?eo ia ?aaeoeaiee a?o?eo // Iaoa??aee iaoeiaeo i?aoeue 2-ai Iaoe?iiaeueiiai eiia?ano ?aaiaoieia?a Oe?a?ie.-Ee?a.-1997.-N.89. 28. A?eiue A.E. Aca?iica’ycie o?aaeaiue noaeia?a ? na?oey o oai?eo ia ?aaiaoi?aeiee a?o?eo // Iaoa??aee 14-ai c’?caeo oa?aiaao?a Oe?a?ie.-Ee?a.-1998.-N.292-294. AIIOAOe?ss A?eiue A.E. Iaoieia?y na?oey i?e caiaeueieo caoai?thaaiiyo noaeia?a (?iciianthaeaeai?noue, ae?aaiinoeea, iaoiaaiac, e?eoaaiiy). – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 – ea?ae?ieia?y. – Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?th i?enay/aii aea/aiith ?iciianthaeaeaiino?, ieoaiiyi ae?aaiinoeee, ii?oieia??, iaoiaaiaco ? e?eoaaiith o?aaeaiue na?oey i?e ?aaiaoi?aeiiio a?o?eo? (?A), iiaeaa??, oai?iaao ?aeoa?a (O?) ? A?oo???aa (OA), a oaeiae o aenia?eiaioaeueieo oaa?ei. O?aaeaiiy na?oey i?e oaeeo caoai?thaaiiyo noaeia?a aaaaoi a /iio aecia/a?oueny oa?aeoa?ii ia?aa?ao noaeiaiaiai neiae?iio. Iacaeaaeii a?ae iicieia?? iioeiaeaeothoueny i?iea?ae, ia?eea?ae e aiaeiea?ae (c oi?ioaaiiyi aaae na?oey), aeieeathoue ii?ooaiiy ?eoio ? i?ia?aeiino?, ?aii oi?io?oueny ei?iia?iea?ae?ineea?ic. Iaoiaaiac ea?ae?aeueii? iaoieia?? i?e a?o?eoao iia’ycaiee c ?ioiieie oa ai?iiiaeueieie ii?ooaiiyie, ci?iaie io?eiiaiai e e?i?aeiiai iai?i?a, ia?aeeniiai ieeneaiiy e?i?ae?a ? aioeieneaeaioieo nenoai. O noeeueiino? aei ?A, O? e OA aenie aianie eaeeioeeoa?ieo aioeaai?a. Aeieeiaiiy iaoieia?? na?oey i?e a?o?eoao i?ecaiaeeoue aei iiyae ea?ae?iaeai?aneaiiai oaeoi?o o e?ia?, ci?iai aeeiai?/iiai iiaa?oiaaiai iaoyao ne?iaaoee. Iaa?oioiaaii aeei?enoaiiy o e?eoaaii? ea?ae?aeueii? iaoieia?? i?e a?o?eoao ieaciaoa?aco ? aaiini?aoe?? c ianooiiei i?iaaaeaiiyi nenoaiii? aiceiioa?ai??. ?iaeea?aeoaeueia iaoiaaiaoe/ia e?eoaaiiy oai?eo c iaoieia??th na?oey aeicaiey? cia/ii iie?aueoe aoaeoeai?noue e?eoaaeueieo caoiae?a. Eeth/ia? neiaa: caiaeuei? caoai?thaaiiy noaeia?a, na?oea, iaoieia?y, ?iciianthaeaeai?noue, ae?aaiinoeea, iaoiaaiac, e?eoaaiiy. AIIIOAOeEss A?eiue A.E. Iaoieiaey na?aeoea i?e ainiaeeoaeueiuo caaieaaaieyo nonoaaia (?ani?ino?aiaiiinoue, aeeaaiinoeea, iaoiaaiac, ea/aiea). – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 – ea?aeeieiaey. – Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Aeenna?oaoeey iinayuaia eco/aieth ?ani?ino?aiaiiinoe, aeeaaiinoeea, aii?inai iaoiaaiaca e ea/aieth ii?aaeaiee na?aeoea i?e ?aaiaoieaeiii a?o?eoa (?A), iiaeaa?a, aieaciyo ?aeoa?a (A?) e Aaooa?aaa (AA). Ii?aaeaiea na?aeoea i?e ainiaeeoaeueiuo caaieaaaieyo nonoaaia ioiineony e iaeaieaa /anoui aenoea?eoai e ai iiiaii ii?aaeaeyaony oa?aeoa?ii oa/aiey nonoaaiiai neiae?iia. ?acaeoea ea?aeeiiaoee /aua ioia/aaony o aieueiuo ?A n aiaea/aieai a iaoieiae/aneee i?ioeann n?aaeieo e e?oiiuo nonoaaia, i?e AA – n iaee/eai nae?ieeaeoa, i?e A? – n a?o?eoii e?anooeiai-iiaeacaeioiuo ni/eaiaiee e nonoaaia ?oe. Iaee/ea ea?aeeiiaoee annioeee?oaony n aieaa oyaeaeui eeeieei-?aioaaiieiae/aneei oa/aieai aieaciae iii?ii-aeaeaaoaeueiiai aiia?aoa, a oi, a naith i/a?aaeue, yaeyaony io?aaeaieai oyaeanoe ii?aaeaiey na?aeoea. I?e a?o?eoao iacaaeneii io iicieiaee ii?aaeathony ieiea?ae, ia?eea?ae e yiaeiea?ae (n oi?ie?iaaieai ii?ieia na?aeoea), aicieeatho ia?ooaiey ?eoia e i?iaiaeeiinoe, ?aii oi?ie?oaony ei?iia?iea?aeeineea?ic, /oi aeey ?aiiae aeeaaiinoeee ea?aeeiiaoee o?aaoao i?iaaaeaiey o anao aieueiuo eiiieaeniiai ianeaaeiaaiey n auiieiaieai yeaeo?iea?aeeia?aoee, ooieoeeiiaeueiuo oa?iaeieiae/aneeo i?ia, /?anieuaaiaeiie yeaeo?iea?aeeinoeioeyoeee, oieoa?ianeiai ea?aeeiiiieoi?e?iaaiey, yoiea?aeeia?aoee, ?aia?aoee, a i?e iaiaoiaeeiinoe yeaeo?ioeceieiae/aneiai enneaaeiaaiey na?aeoea. Ii?oieiae/aneay ea?oeia a na?aeoea i?e ainiaeeoaeueiuo aieaciyo nonoaaia aanueia ?aciiia?acia, i?e/ai eiathony eae iauea, oae e niaoeeoe/aneea aeey oiai eee eiiai caaieaaaiey eciaiaiey, iaoneiaeaiiua eiioiiuie e iaoaaiee/aneeie ?anno?ienoaaie. Iaoiaaiac ea?aeeaeueiie iaoieiaee i?e a?o?eoao oanii naycai n eiioiiuie ia?ooaieyie, i /ai naeaeaoaeuenoaoao aeenaaeain iniiaiuo eeannia eiioiioeeoia, nieaeaiea ooieoeeiiaeueiie aeoeaiinoe eeioioeeoia e iieeioi?iiyaea?iuo iaeo?ioeeia, aeia?i?iaeoeoeey ?acee/iuo aooiaioeaaiia. Oyaeanoue eciaiaiee eiioiieiae/aneeo iieacaoaeae ei??aee?oao ni noaiaiueth aeoeaiinoe a?o?eoia e ii?aaeaeyao oa?aeoa? ea?aeeaeueiiai neiae?iia. Eiioiiua oaeoi?u o/anoaotho a ?acaeoee ia oieueei ii?aaeaiey na?aeoea i?e ?A, A? e AA, ii e i?e iiaeaa?a, /oi aeieacuaaaony eae eeeie/aneeie, oae e yenia?eiaioaeueiuie enneaaeiaaieyie n eco/aieai o aeeaioiuo no?oeoo? eiioiieiiiaoaioiuo i?aaiia e ninoiyiey eiioieoaoa. I?e yenia?eiaioaeueiie iiaeaa?e/aneie ea?aeeiiaoee i?ienoiaeeo ia?ooaiea yeaeo?e/aneie noaaeeueiinoe na?aeoea, a aneaaenoaea aeia?o?eeaiee eciaiyaony aeoeaiinoue oa?iaioiaa io?eiiaiai iaiaia a no?oeoo?ao aieiaiiai iicaa e oooaeoathony ?aca?aiua aiciiaeiinoe iaoaaieecia aaeaiiceia a nainiiioi?iie ei?a, aeiioaeaiona, aeiiieaiia. A ?acaeoee iaoieiaee na?aeoea i?e ainiaeeoaeueiuo caaieaaaieyo nonoaaia i?ienoiaeyo aeenai?iiiaeueiua ia?ooaiey n eciaiaieai aaeaina iieiauo, aiiaaeio?iiiuo, oe?aieaeiuo, aetheiei?oeeieaeiuo ai?iiiia e ai?iiiia ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu, eioi?ua ii?aaeaeytho oa?aeoa? oa/aiey ea?aeeiiaoee. Iacaaeneii io iicieiae/aneie oi?iu a?o?eoia i?ienoiaeyo nouanoaaiiua eciaiaiey io?eiiaiai e eeieaeiiai iaiaiia n aeoeaaoeeae i?ioeannia ia?aeeniiai ieeneaiey eeieaeia e oaiaoaieai aioeieneaeaioiuo nenoai, /oi ei??aee?oao n oa?aeoa?ii e oyaeanoueth oa/aiey iaoieiaee na?aeoea. Oioy aeeaae iaeioi?uo eaeeioeeoa?iuo aioeaaiia a i?aae?aniieiaeaiiinoue ?A, A? e AA aeinoaoi/ii aunie, ioiineoaeueiue ?ene aicieeiiaaiey iaoieiaee na?aeoea i?e oaeeo caaieaaaieyo ii?aaeaeytho niaa?oaiii ae?oaea aioeaaiu, eioi?ua oanii naycaiu n ?acaeoeai e ia?ae/iuo caaieaaaiee na?aeoea. Yoi iicaieyao a naiii aeaathoa a?o?eoa i?iaiice?iaaoue aa?iyoiinoue iiyaeaiey ia iineaaeothueo yoaiao ea?aeeiiaoee. Aicieeiiaaiea iaoieiaee na?aeoea i?e a?o?eoao aaaeao e iiyaeaieth ea?aeeiaeai?anneaiiai oaeoi?a a e?iae, i?e/ai o?aeoeey nuai?ioee aieueiuo n ?aciuie caaieaaaieyie ieacuaaao ia eciee?iaaiiia na?aeoea aeeaioiuo ia ioiioeiiia (/anoi ?aciiiai?aaeaiiia) aeaenoaea ia ninoiyiea aaiiaeeiaieee. Eciaiaiey niaea?aeaiey aaeeia e eeieaeia a e?iae i?e ainiaeeoaeueiuo aieaciyo nonoaaia aaaeao e ia?ooaieth ea/anoaaiiiai e eiee/anoaaiiiai ninoaaa no?oaeoaioia e iiaa?oiinoii-eiaeoeaiuo niaaeeiaiee, /oi io?aaeaaony ia ninoiyiee aeeiaie/aneiai iiaa?oiinoiiai iaoyaeaiey nuai?ioee. Ia?aiao?u iaaeoaciie oaiceiiao?ee io?aaeatho iaee/ea ii?aaeaiey na?aeoea e a eioaa?aeueiii aeaea iiaoo auoue e?eoa?eyie yooaeoeaiinoe ea/aiey oaeie eaoaai?ee aieueiuo. Iainiiaaii eniieueciaaiea a ea/aiee ea?aeeaeueiie iaoieiaee i?e a?o?eoao ieaciaoa?aca e aaiini?aoeee n iineaaeothuei i?iaaaeaieai nenoaiiie yiceiioa?aiee. Ia?ooaiey io?eiiaiai iaiaia o?aaotho iacia/aiey o?eeiaeai?anneaiuo i?aia?aoia, a aee?iaiai – aeiieeieaeaie/aneeo n?aaenoa. I?eciaee aeaaea ne?uoie aeenooieoeee eaaiai aeaeoaei/ea aeeeootho iaiaoiaeeiinoue i?eiaiaiey o oaeeo aieueiuo eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa e aioaaiienoia eaeueoeey. Eiaeeaeaeoaeueiia iaoiaaiaoe/aneia ea/aiea aieueiuo n iaoieiaeae na?aeoea iicaieyao cia/eoaeueii iiauneoue yooaeoeaiinoue i?iaiaeeiuo ea/aaiuo ia?ii?eyoee. Eeth/aaua neiaa: ainiaeeoaeueiua caaieaaaiey nonoaaia, na?aeoea, iaoieiaey, ?ani?ino?aiaiiinoue, aeeaaiinoeea, iaoiaaiac, ea/aiea. SUMMARY Grin V.K. Heart Pathology at Inflammation of Joints (Diffusion, Diagnostiks, Pathogenesis, Treatment). – Manuscript. The dissertation for a doctor’s degree by speciality 14.01.11 – Cardiology. – Charkov State Medical University, Charkov, 1999. The dissertation is concerned with the study of spreading, diagnostics, morphology, pathogenesis and treatment of cardiac disease at rheumatoid arthritis (RA), Gouty, Reiter disease (RD), and disease of Bechterev (BD), as well as at experimental animals. Cardiac injury at these diseases are greatly determined by the character of the development of joint syndrome. Irrespective of nozology injury is caused myocardium, pericardium and endocardium ( with the formation defects of heart), there occur disorders of rhythm and conductivity accompanied by early formation of coronary cardiosclerosis. Pathogenesis of cardiac pathology at arthritis is connected with immune and hormone disorders, deviation of purine and lipid exchange, peroxide oxidation of lipids and antioxidant systems. The contribution of leucocytic antigens diathesis to RA, BD, RD is rather great. Occurrence of cardiac pathology at arthritis causes formation of cardio depressive factor in blood, change of dynamic surface tension of serum. Application of plasmaferous and haemasorption with further system enzymotherapy during treatment of cardiac pathology at arthritis firmly substantiated. Individual pathogenically oriented approach to the patient with heart pathology allows to highly improve efficiency of applied treatment technologies. Key words: inflammation of joints, heart, diffusion, diagnostics, pathogenesis, treatment. IA?AE?E OIIAIEO NEI?I*AIUe A aeueaeinoa?ii AA ?-aae?aiiaeieaoi?e AAeA aaeaiiceiaeacai?iaca AE aioaaii?noe eaeueoe?th Aioe-aeAeIE aioeo?ea aei aeaiaoo?iaaii? AeIE Aioe-iAeIE aioeo?ea aei iaoeaii? AeIE AEIIA aeieaaea e?ai? iiaeee io/ea A?no AIIIA aeieaaea i?aai? i?aeee io/ea A?no AAI aaeia?aiiao??y AeE ae??iia? eii’thaaoe AeIE aeaciene??aiioeea?iiaa eeneioa AeOeo ae?anoie?/iee oene e?aiai oeoii/ea A ano?aae?ie AEA aeaeo?iea?ae?ia?ao?y A?II aoaeoeaiee ?ao?aeoa?iee ia??iae ia?aaena?aeue AOAe aeaeo?io?c?ieia?/ia aeine?aeaeaiiy AoiEA aoiea?ae?ia?ao?y CINI caaaeueiee ia?eoa?e/iee noaeeiiee ii?? ?AIO ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo ?A ?ioiiaeiaoe?i E ei?oecie EIE eoo iaoeeo e?eai? oaic?ia?ai EI enaioeiieneaeaca Eii eiieaiaaae?i A E*AONA ei?aaiaaiee *AONA E etho?ii?i EIAA e?iii?ioa?aee aeniei? aonoeie EIAeIA e?iii?ioa?aee aeoaea iecueei? aonoeie EIIA e?iii?ioa?aee iecueei? aonoeie ?2-IA ?2-i?e?iaeiaoe?i IAe iaeiiiaee ae?aeueaeaa?ae 5I 5-ioeeaioeaeaca IICI ianoa?i?aei? i?ioecaiaeuei? i?aia?aoe INO i?o?inei?e oao?acie?e II ieneio?eiie I i?iaanoa?ii IA iiaeaa?e/iee a?o?eo IA i?inoaaeaiaeei IIA i?ioei?iea?ae?aeuei? aioeo?ea II iiaa?oiaaee iaoya IIE ia?aeenia ieeneaiiy e?i?ae?a INA i?ioeneiia?aeuei? aioeo?ea INaeA i?ioenaeac?ieia? aioeo?ea IOA i?ioeoeioni? aioeo?ea ? ?ai?i ?A ?aaiaoi?aeiee a?o?eo ?AOE ?aaeoe?y aeanoii? o?ainoi?iaoe?? e?ioioeeo?a ?A ?aia?ao?y NE na/iaa eeneioa NNNA neiae?ii neaaeino? neioniaiai aocea NOeo nenoie?/iee oene e?aiai oeoii/ea O oanoinoa?ii O3 o?eeiaeoe?ii?i O4 oe?ienei OA o?eae?oea?eaee ONOe o?eaae?noue na?oeaaiai oeeeeo OOA oe?aio?iiiee ai?iii OO ?-oieioa?ie O oie?o?ii?i OAI oaaioeeoa?ia aeoeai?noue iaeo?io?e?a OAA o?oiaaiaaethoei?i O?I oaaioeeoa?iee ?iaeaen iaeo?io?e?a OI o?a?iiaeoei OA oai?iaa A?oo???aa O? oai?iaa ?aeoa?a ON oieanoa?ei OEI oieoa?ianueea ea?ae?iiiiaoi?oaaiiy Oe?E oee?eoethth/? ?ioii? eiiieaene *AONA /an a?aeiiaeaiiy ooieoe?? neioniaiai aocea *NAI /an neiiao??aeueiiai i?iaaaeaiiy *NAN /a?acno?aaio?aeia aeaeo?iea?ae?inoeioeyoe?y

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