?inoeooo iaae?ao???, aeooa?noaa OA a?iaeieia??

Aeaaeai?? iaaee/ieo iaoe Oe?a?ie

Aaiaaeeaa Iaoae?y Aanee?aia

OAeE: 616.233/.24-091-053.2

Ee?i?ei-iaoiaaiaoe/i? aniaeoe o?ii?/ieo ? ?aoeeaeeaoth/eo ianiaoeeo?/ieo
a?iioieaaaiaaeo caoai?thaaiue o aeeoy/iio a?oe?

oa ?o e?eoaaiiy

14.01.10 – iaae?ao??y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999 Aeena?oaoe?y ? ?oeiienii.

?iaioo aeeiiaii a Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai??
?i. ?.ss.Ai?aa/aanueeiai IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, i?ioani?, /eai-ei?aniiiaeaio AII Oe?a?ie Ni?yi
?aai Naiaiiae/, Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y
?i. ?.ss.Ai?aa/aanueeiai IIC Oe?a?ie, caa?aeoaa/ eaoaae?e iaae?ao???.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?, Caneoaeaiee ae?y/ iaoee ? oaoi?ee
Oe?a?ie Aiae?ouoe Ae?na Iiaian?aia, Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i. I.I.Aiaiiieueoey IIC Oe?a?ie (i. Ee?a), i?ioani? eaoaae?e iaae?ao???
?1;

aeieoi? iaaee/ieo iaoe, i?ioani? Eaneoey Ieueaa ?ea??ii?aia, Ee?anueea
iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,
caa?aeoth/a eaoaae?e iaae?ao??? ?1, aieiaiee aeeoy/ee aea?aieia IIC
Oe?a?ie;

aeieoi? iaaee/ieo iaoe, i?ioani?, Caneoaeaiee ae?y/ iaoee ? oaoi?ee
Oe?a?ie E?nyiee Ieeiea ?aaiiae/, ?inoeooo iae?io??o?a?? AII Oe?a?ie,
caa?aeoaa/ a?aeae?eii iae?i?ioiieia??.

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC
Oe?a?ie, eaoaae?a aini?oaeueii? iaae?ao??? ?2.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 9 ” eenoiiaaea 1999 ?ieo i 13
 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae. 26.553.01 ii
caoenoo aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaoe ca
niaoe?aeueiinoyie “Iaae?ao??y”, “Aeooa?noai oa a?iaeieia?y” i?e
?inoeooo? iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050,
i. Ee?a, aoe. Iaio?euenueeiai, 8)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i. Ee?a,
aoe. Iaio?euenueeiai, 8)

Aaoi?aoa?ao ?ic?neaiee “8 ” aeiaoiy  1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Eaaoi?ia E.A.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. A?iioieaaaiaaa iaoieia?y o ae?oae a no/anieo oiiaao
iaaoea noaoono aeieia?/ii aeaoa?i?iiaaii? iaoieia?? (I.I.Eoe’yiiaa,
1996; Ae.Ae.Ca?a?ii, 1995; ?.N.Ni?yi, 1998), a oiio ?aoeeaeeaoth/a oa
o?ii?/ia i?eaa?oa? iniaeeao oaaao i?ia?aeieo iaoeiaoe?a oa ee?i?oeeno?a.
A ?? no?oeoo?? aeii?iothoue ?aoeeaeeaoth/ee a?iio?o, a?iio?aeueia anoia,
eio?? noaee i?aaeiaoii aeine?aeaeaiiy. Aea?? iaoiiaeaiee aiaeii/an
neooaoe??th, ui neeaeany i?ioyaii inoaii?o ?ie?a i?ae aieeaii eiiieaeno
aeieia?/ieo eaoano?io ia Oe?a?i? ? iieyaa? o o??aae? i?ia?aeieo
iicieia?/ieo oi?i: iaoieia?y i?aai?a aeeoaiiy, aea?a?/i? caoai?thaaiiy,
aiai?? (I.I.Eoe’yiiaa, 1995; TH.A.Aioeie?i, 1996; TH.A.Aaeueoeuaa,
1996).

Aeooaeuei?noue i?iaeaie ia ciaioo?oueny, iacaaaeath/e ia /enaeuei?
iaoeia? ?ic?iaee (?.A.Aa?acthe, 1996; I.?.Aaee/ei, 1997; A.A.Ii/eaaeia,
1998), ine?eueee caoai?thaai?noue a?iio?aeueiith anoiith,
?aoeeaeeaoth/ei a?iio?oii c?inoa?, a oaeiae ?i i?eoaiaii? ?aii?e ii/aoie
oai?iae (TH.E.Aieueaio, 1994; I.?.Eaneoey, 1994, 1998). ?aoeeaeeaoth/o
oa o?ii?/io a?iioieaaaiaao iaoieia?th aecia/a? aeeaeia caiaeaiiy
(N.TH.Eaaaiia, 1995, 1999; C.I.Iaiaec?e, 1996; A.O.Iicaeaanueeee, 1998),
eio?a ??ciia?/ii aea/aeiny (?.I.Eaio?, 1993; I.E.Aycieeiaa, 1997;
A.A.Eeeiaineay, 1998). Iaeiae, ? aeioaia? ?niothoue o?oaeiiu?
?aeaioeo?eoaaoe aeeaeio caiaeueiiai i?ioeano ee?i?/ii, eaai?aoi?ii,
aiaeineii?/ii, a c oeei – ? a?aoiaoaaoe eiai aeeiai?eo. A oiio a ?iaio?
ai?iaiaai? iia? eiiieaene eaai?aoi?ieo oano?a aeyaeaiiy nooiaiy
caiaeaiiy i?e caaino?aii? a?iioieaaaiaaeo caoai?thaaiue. ?o ?ic?iaea
coiiaeaia oei, ui ia aeaiiio aoai? caiaeaiiy oa?aeoa?eco?oueny ?aii?i,
aeeaieei ? aeeoociei o?aaeaiiyi neeciai? a?iio?a o ii?aeiaii? c
ii?ooaiiyi aaioeeyoe?eii? caeaoiino? eaaaiue.

Oeaio?aeueiei i?noeai ?icaeoeo caiaeueiiai i?ioeano a?ae neeciai?
a?iio?a aei ia?aio?ie eaaaiue – ? niieo/iioeaieii? aeaiaioe. ?o iai?i o
cia/i?e i??? aieeaa? ia ooieoe?iiaeuei? ?aca?ae i?aai?a aeeoaiiy, iaeiae
iaoeia? aeine?aeaeaiiy iiiaeeiie? (E.A.Aiaaaeaeueieeia, 1991;
A.A.Aa?aneiia e niaao, 1991; A.I.Eiiae?aoue?a, 1998). Aiaeii/an i?e
?aoeeaeeaoth/iio a?iio?o? oeei aniaeoai ia iaaea?oueny iaeaaeia oaaaa
aeeoy/eie ioeueiiiieiaaie.

Eiiieaen aeine?aeaeaiue, i?enay/aieo aea/aiith cia/aiiy
iaia?aiiaeano?oeoeaieo i?ioean?a (E.I.Eaiaoiien e niaao., 1994;
A.A.Eoaeoe?i, 1994; A.E.I?aoei e niaao., 1997), ?ioiieia?/ieo iaoai?ci?a
(A.A.Aiai?aae e niaao., 1996; TH.A.Aaiaineee e niaao., 1998) o
iaoiaaiac? ?aoeeaeeaoth/eo ? o?ii?/ieo a?iioieaaaiaaeo caoai?thaaiue,
caeaa?eueoiai ?icaeyaeathoue ?o ?ic??ciaii, ia i?noyoue e?eoa???a
ae?aaiinoeee aeeaeie caiaeaiiy. Iiaeeaeaiee aiae?c caeiiii??iinoae
ia?ieneaeaoe?? e?i?ae?a, aeoeaiino? cania?a ??cieo ??ai?a
aioeieneaeaioiiai caoenoo iaeii/anii aea? iiaeeea?noue ioa?aeoa?ecoaaoe
oyaee?noue caiaeueiiai i?ioeano.

Iaiiiaeeiie? ni?iae aaeineiiaeeoe ?nioth/? i?aeoiaee aei e?eoaaiiy
o?ii?/ii? oa ?aoeeaeeaoth/i? iaoieia?? i?aai?a aeeoaiiy caeaa?eueoiai
a?oioothoueny ia i?aaiaii? nei?eaoaaoe oo /e ?ioo eaieo niioai?aiiai
aiiainoaco. Iaeiae, no/ania oa?ai?y iiaeiia aacoaaoeny ia i?eioeeiao
iioeiaeueii i?i?iaeueiiai iaaeeeaiaioiciiai e?eoaaiiy, a oaeiae
eiiieaeniino? eiai ae??. C oeeo iiceoe?e aaa/a?oueny aeioe?eueiith
ai?iaaoe?y iiaeo noai e?eoaaiiy, eio?? a caaacia/eee o?eaaeo ?ai?n?th,
oieeath/e iie?i?aaiac??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, oaiaie. Aeena?oaoe?eia ?iaioa ?
o?aaiaioii iaoeiai? ?iaioe “Aiaeiaaiia ?ioieneeaoe?y o ae?oae c ??ciith
iaoieia??th oa ?? aieea ia iaoieia?/i? iaoai?cie ? ee?i?/i? i?iyae
caoai?thaaiue” (iiia? aea?ae?a?no?aoe?? – 0196U023277) eaoaae?e
iaae?ao??? Oa?iii?euenueei? iaaee/ii? aeaaeai?? ?i. ?.ss.Ai?aa/aanueeiai
IIC Oe?a?ie.

Iaoa ?iaioe. Aaeineiiaeeoe iaoiaee ae?aaiinoeee aeoeaiino? caiaeueiiai
i?ioeano oa i?aeaeueoe aoaeoeai?noue e?eoaaeueieo caoiae?a i?e
?aoeeaeeaoth/iio, o?ii?/iiio a?iio?o?, aoi?eii?e o?ii?/i?e iiaaiii??,
a?iio?aeuei?e anoi? o ae?oae.

Caaea/? aeine?aeaeaiiy.

Aeine?aeeoe noai iaoaaie?cio niieo/iioeaieiieo aeaiaio?a i?e caaino?aii?
?aoeeaeeaoth/iai a?iio?oo, o?ii?/iiai a?iio?oo, aoi?eiii? iiaaiii?? oa
a?iio?aeueii? anoie.

Anoaiiaeoe nooi?iue ?ioiieia?/ii? iaaeinoaoiino? oa ni?aa?aeiioaiiy
oa?iaio?a ??cieo e?i?e aioeieneaeaioiiai caoenoo i?e caaino?aii?
?aoeeaeeaoth/iai a?iio?oo, a?iio?aeueii? anoie, o?ii?/ieo a?iio?oo oa
aoi?eiii? iiaaiii??.

C’ynoaaoe noaae?ei?noue ?icaeoeo aiaeiaaiii? ?ioieneeaoe?? o ae?oae ?c
?aoeeaeeaoth/ei oa o?ii?/iei a?iio?oii, aoi?eiiith iiaaiii??th,
a?iio?aeueiith anoiith.

Aea/eoe e?eoa??? aeoeaiino? oa aeeaeie aiaeia?iio?oo i?e aoi?eii?e
o?ii?/i?e iiaaiii??, ?aoeeaeeaoth/iio a?iio?o?, a?iio?aeuei?e anoi? ca
aeaieie aeine?aeaeaiiy a?iioiaeueaaiey?iiai cieao.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ai?iaoaaoe iia? noaie e?eoaaiiy
a caeaaeiino? a?ae aeeaeie iaoaaie?/ieo c?ooaiue.

Aea/eoe a eaoaiiac? noai ??cieo iieaciee?a aiiainoaco i?ney
iiaeeo?eiaaiiai e?eoaaiiy ?aoeeaeeaoth/i? oa o?ii?/ii? iaoieia??
eaaaiue.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Ia iniia? i?iaaaeaieo
ee?i?ei-eaai?aoi?ieo oa ?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy
aeyaeaii, ui caaino?aiiy ?aoeeaeeaoth/iai a?iio?oo, a?iio?aeueii? anoie,
o?ii?/ii? iaoieia?? eaaaiue oa?aeoa?eco?oueny eiiieaenii ci?i o nenoai?
aiiainoaco, ye? aecia/athoue aeeaeio caiaeueiiai i?ioeano oa oyaee?noue
ia?aa?ao caoai?thaaiiy.

Aia?oa aeine?aeaeaia aeoeai?noue i?ioean?a ?oiaeiiaioeo?eiooai?aiiy i?e
?aoeeaeeaoth/iio a?iio?o?, o?ii?/i?e iiaaiii??, a?iio?aeuei?e anoi?, ui
ianooue ?ioi?iaoe?th i?i aeeaeio caiaeaiiy oa caeaaeaoue a?ae o?eaaeino?
iniiaiiai caoai?thaaiiy, ia’?io o?aaeaiiy oa no?oeoo?e noiooiuei?
iaoieia??.

I?inoaaeaii iniaeeaino? iaoaaie?cio niieo/iioeaieiieo aeaiaio?a o ae?oae
?c caaino?aiiyi ?aoeeaeeaoth/iai a?iio?oo oa ae?noaei iiaeaeueoiai
?icaeoeo aea/aiiy caaaeaieo i?ioean?a i?e o?ii?/i?e iaoieia??.
Aeaci?aai?caoe?y niieo/ii? oeaieie oo?eio?oueny ? a ia??iae? ee?i?/ii?
?ai?n??, ui iiaea aooe i?eaiaeii aei /a?aiaiai caaino?aiiy.

Aeaoaeueii i?aaenoaaeai? i?e/eii? ca’ycee i?ae aeenaaeainii
aioeieenethth/eo cania?a o?ueio e?i?e aioeieneaeaioii? nenoaie e
aeoeai?noth a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a o ia??iae
caaino?aiiy o?ii?/ieo ? ?aoeeaeeaoth/eo a?iioieaaaiaaeo caoai?thaaiue, a
oaeiae aecia/aiee oaeoi? aioeieneaeaioiiai noaio. Iaa?oioiaaii, ui
caaino?aiiy a?iio?aeueii? anoie a?aeiia?aea? noaio oieiai?
iaia?aiiiao??, a ?aoeeaeeaoth/iai a?iio?oo, o?ii?/ieo a?iio?oo oa
aoi?eiii? iiaaiii?? – iaia?aiiiao??.

Icia/aia no?oeoo?a ci?i ?ioiia?io?i?/iiai i?io?eth a?iioiaeueaaiey?iiai
cieao oa aecia/ai? oaiaeaioe?? ?o ?icaeoeo a caeaaeiino? a?ae nooiaiy
aiaeia?iio?oo i?e ie?aieo iicieia?/ieo oi?iao.

Aia?oa iaoiaaiaoe/ii iaa?oioiaaii, ai?iaiaaii oa i?iaaaeaii ioe?ieo
aoaeoeaiino? aeei?enoaiiy e?iinoaa?eo, ?eaieneio aeey ei?aeoe?? c?ooaiue
aiiainoaco i?e o?ii?/i?e ? ?aoeeaeeaoth/?e a?iioieaaaiaa?e iaoieia??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?acoeueoaoe aeine?aeaeaiue
aea/aiiy ?ioiieia?/ii? ??aiiaaae, iaoaaie?cio niieo/ii? oeaieie,
ooieoe?iiaeueiiai noaio aioeieneaeaioii? nenoaie, ia?aa?ao oa
noaae?eiino? neiae?iio aiaeiaaiii? ?ioieneeaoe??, ?ioiieia?/ieo oa
a?io?i?/ieo oa?aeoa?enoee a?iioiaeueaaiey?iiai cieao a ae?oae ?c
?aoeeaeeaoth/ei ? o?ii?/iei a?iio?oii oa a?iio?aeueiith anoiith,
?ice?eaathoue iniaeeaino? iaoiaaiaco o?ii?/ieo ? ?aoeeaeeaoth/eo
a?iioieaaaiaaeo caoai?thaaiue. Aiie aeathoue /?oe? e?eoa??? ioe?iee
aeoeaiino? caiaeueiiai i?ioeano a aeeoaeuei?e nenoai?, ui aeiiiiiaea
e?ea?th /?oei ?aeaioeo?eoaaoe ia??iae caaino?aiiy /e ?ai?n??. Ie??i
oiai, ?acoeueoaoe niaoe?aeueieo iaoiae?a aeine?aeaeaiiy aeathoue ciiao
aeeoa?aioe?thaaoe ie?ai? iicieia?/i? oi?ie.

Aeine?aeaeaia aeoeai?noue i?ioean?a eieaaaiiooai?aiiy, ui ?ethno?othoue
caiaeueiee i?ioean i?e a?iioieaaaiaa?e iaoieia?? a oiiaao aoi?eiiiai
?ioiiaeao?oeeoiiai noaio, a oiio aieeaathoue ia oyaee?noue ia?aa?ao
oai?iae. Aeine?aeaeaiiy ooieoe?iiaeueii? ni?iiiaeiino? i?e?iaei?o
aeaoieneeaoe?eieo nenoai (ie?ee, a?eo?ioeeoe) oa ??aiy aiaeioienai?? o
oeeo oai?eo aeaee i?aenoaae iaoiaaiaoe/ii iaa?oiooaaoe aeioe?euei?noue
aeeoa?aioe?eiaaiiai aeei?enoaiiy aioa?ini?aoe??.

Ai?iaiaai? oae? ianiaoeeo?/i? ?ioiiiiaeoeyoi?e, ye ?eaienei, e?iinoaa?e
i?e o?ii?/i?e ? ?aoeeaeeaoth/?e a?iioieaaaiaa?e iaoieia?? oa aea/aiee ?o
aieea ia ?io? iieacieee aiiainoaco. ?acoeueoaoe ?iaioe iaoeiai
iaa?oioiaothoue ?iaeea?aeoaeuei? i?aeoiaee aei e?eoaaiiy oa
?aaa?e?oaoe??, ui ni?ey? ae??oaiith i?iaeaie ?iaeea?aeoaeueii?
iaoiaaiaoe/ii? oa?ai??.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo. ?acoeueoaoe i?iaaaeaieo
aeine?aeaeaiue ai?iaaaeaeai? ia aac? ioeueiiiieia?/ieo a?aeae?eaiue
aeeoy/i? iaeanii? ee?i?/ii? oa i?nueei? e?ea?aiue i. Oa?iiiiey, aeeoy/eo
a?aeae?eaiue Oe?E Caa?acueeiai, E?aiaiaoeueeiai, Eic?anueeiai,
Oa?aaiaeyinueeiai ?aeii?a Oa?iii?euenueei? iaeano?, Aeoai?anueei? Oe?E
??aiainueei? iaeano?, Ieanueei? ?aeiiii? e?ea?i? Euea?anueei? iaeano?,
?iiainueei? Oe?E Noinueei? iaeano?, iaeanii? aeeoy/i? e?ea?i?
i. Oaeai?iae, ?iaaoeinueeiai oa?eoi??aeueiiai iaaee/iiai ia’?aeiaiiy
?aaii-O?aie?anueei? iaeano?.

Iniiai? iieiaeaiiy ?iaioe aeei?enoiaothoueny ia i?aeoe/ieo caiyooyo
nooaeaio?a c oaeoeueoaonueei? iaae?ao??? iaaee/iiai oaeoeueoaoo
Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??
?i. ?.ss.Ai?aa/aanueeiai IIC Oe?a?ie. ?acoeueoaoe ?iaioe ai?uai? o 2
ee?i?/ieo eaeoe?yo, aeaeaieo aeey nooaeaio?a, oa 3 ?aoe?iiae?caoi?nueeeo
i?iiiceoe?yo:

eaai?aoi?i? e?eoa??? aiaeiaaiii? ?ioieneeaoe?? i?e caoai?thaaiiyo
a?iioieaaaiaai? nenoaie a aeeoy/iio a?oe? ?17 a?ae 18.06.1994 ?.;

eiiieaenia e?eoaaiiy ii?ooaiue ?ioiiaaiaco i?e a?iio?aeuei?e anoi? o
ae?oae ca aeiiiiiaith aioa?ini?aoe?? oa oeiae?io ?20 a?ae 27.06.1994 ?.;

canoinoaaiiy aioa?ini?aoe?? o eiiieaeniiio e?eoaaii? a?iio?aeueii? anoie
o ae?oae ?18 a?ae 21.06.1994 ?.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aea?aiee iai?yiie
?iaioe, ia’?i iaoeiaiai aeine?aeaeaiiy, iniaenoi i?iaaaeaiee aiae?c
a?o/eciyii? oa ?iicaiii? e?oa?aoo?e ca ia?aiith i?iaeaiith,
noi?ioeueiaai? iaoa oa caaaeaiiy aeine?aeaeaiiy. Naiino?eii i?iaaaeaia
ieaioaaiiy aeine?aeaeaiue, a?aea?? oai?eo, noai?aiiy aace eiiieaeniiai
ianoaaeaiiy ae?oae on?o a?oi oa i?iaaaeaiiy o ieo aeeoa?aioe?eiaaieo
iaoiae?a e?eoaaiiy, aiae?c oa noaoenoe/ia ia?iaea aeaieo, ocaaaeueiaiiy
?acoeueoao?a aeine?aeaeaiiy. Aeena?oaioii i?iaaaeaiee aiae?c
ei?aeyoe?eieo aca?iica’yce?a aeine?aeaeoaaieo iieaciee?a. Aaoi?
naiino?eii iaa?oiooaaea ? noi?ioethaaea ?aeiiaiaeaoe?? ii e?eoaaiith
ae?oae ?c o?ii?/iith oa ?aoeeaeeaoth/ith ianiaoeeo?/iith
a?iioieaaaiaaith iaoieia??th.

Ai?iaaoe?y aeena?oaoe??. Iniiai? iieiaeaiiy ?iaioe aeiiia?aeaeeny ia
ui??/ieo i?aenoieiaeo iaoeiai-i?aeoe/ieo eiioa?aioe?yo Oa?iii?euenueei?
iaaee/ii? aeaaeai?? (1994–1999 ??.), ia can?aeaiiyo iaeanii? anioe?aoe??
aeeoy/eo e?ea??a (1996–1998 ??.), Ieaioi? iaoeiai-iaaee/iiai oiaa?enoaa
aeeoy/eo e?ea??a “?aaa?e?oaoe?y a iaae?ao???” (Ee?a–Oa?iii?eue, 1995), ?
I?aeia?iaeiiio eiia?an? c ?ioaa?aoeaii? aio?iiieia?? (Oa?iii?eue, 1995),
I?aeia?iaeiiio eiia?an? iieiaeeo a/aieo Oe?a?ie (?aaii-O?aie?anuee,
1995), I?aeia?iaei?e eiioa?aioe?? “Aeooaeuei? ieoaiiy ii?oieia??”
(Oa?iii?eue, 1996), eiioa?aioe?? “Aeooaeuei? ieoaiiy oai?aoe/ii? oa
ee?i?/ii? iaaeeoeeie ia no/aniiio ??ai?” (Iieoaaa, 1996), Ia?oiio
Oe?a?inueeiio eiia?an? aano?iaioa?ieia?a (Aei?i?iiao?ianuee, 1996),
eiioa?aioe?? “Aeieia?y oa noai caei?ia’y ianaeaiiy a no/anieo oiiaao”
(Oaeai?iae, 1996), ? iaoeiai-i?aeoe/i?e eiioa?aioe?? “A?ini?aoe?ei?
iaoiaee ? i?aia?aoe a i?io?eaeoe/i?e oa e?eoaaeuei?e i?aeoeoe?” (Ee?a,
1997), eiioa?aioe?? “Iaoiaeieia?/i? iniiae aeeeaaeaiiy oa iaoeia?
i?iaeaie aeieia?? nueiaiaeaiiy” (Oa?iii?eue, 1997), ? Iaoe?iiaeueiiio
eiia?an? o?c?ioa?aiaao?a ? eo?i?oieia?a Oe?a?ie “O?ce/i? /eiieee a
iaaee/i?e ?aaa?e?oaoe??” (Oi?eueiee, 1998), ?? I?aeia?iaeiiio eiia?an? c
?ioaa?aoeaii? aio?iiieia?? (A?iieoey, 1998), ?? eiioa?aioe?? Anioe?aoe??
aeeoy/eo e?ea??a Oe?a?ie “E?eoaaeueii-i?io?eaeoe/ia oa?/oaaiiy oa
i?ia?ioeee a iaae?ao???” (Ee?a, 1998), ? Iaoe?iiaeueiiio eiia?an?
Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe?? (Aeoooa, 1998),
Oe?a?inuee?e ?anioae?eainuee?e eiioa?aioe?? “Aeooaeuei? ieoaiiy
ee?i?/ii? iaaeeoeeie oa aeieia??” (Iieoaaa, 1998), ?anioae?eainuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? ieoaiiy iaaeeoeeie”
(Oiaeueieoeueeee, 1998), i?aeia?iaeiiio neiiic?oi?, A?ei?on?y, A?iaeii
(1998), ??? I?aeia?iaeiiio eiia?an? iieiaeeo a/aieo ? nooaeaio?a
(Oa?iii?eue, 1999).

Ioae?eaoe??. ?acoeueoaoe iaoeiaeo aeine?aeaeaiue, ui i?noeoue
aeena?oaoe?y, aena?oeai? o 35 iaoeiaeo i?aoeyo, c ieo: 1 iiiia?ao?y, 22
aeo?iaeuei? noaoo?, 12 ?ia?o o ca??ieeao iaoeiaeo i?aoeue, iaoa??aeao
eiia?an?a, eiioa?aioe?e.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 367 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e, iieno
iaoa??ae?a ? iaoiae?a aeine?aeaeaiiy, 4 ?icae?e?a aeanieo
aeine?aeaeaiue, aiae?co io?eiaieo ?acoeueoao?a, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, ia?ae?eo aeei?enoaii? e?oa?aoo?e (466 aeaea?ae, ?c ieo
329 a?o/eciyieo ? 167 ?iicaiieo, ye? caeiathoue 55 noi??iie). ?iaioa
?ethno?iaaia 32 oaaeeoeyie ? 34 ?enoieaie, ui caeiathoue 69 noi??iie, 4
aeieneaie c ?noi??e oai?iae ae?oae, ui aoee i?ae niinoa?aaeaiiyi.

Ci?no ?iaioe

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. Ianoaaeaii 556 ae?oae a?eii a?ae 2
aei 14 ?ie?a, ?c ieo 330 oai??ee a?iio?aeueiith anoiith (AA), 134 –
?aoeeaeeaoth/ei a?iio?oii (?A), 22 – o?ii?/iith aoi?eiiith iiaaiii??th,
70 – o?ii?/iei a?iio?oii, eio?? ciaoiaeeeeny ia noaoe?iia?iiio e?eoaaii?
a ioeueiiiieia?/iiio a?aeae?eaii? Oa?iii?euenueei? iaeanii? aeeoy/i?
ee?i?/ii? e?ea?i? c i?eaiaeo caaino?aiiy iniiaiiai caoai?thaaiiy. A?oio
eiio?ieth neeaee 80 caei?iaeo ae?oae aiaeia?/ii? a?eiai? eaoaai???.

Aa?eo?eaoe?y ee?i?/iiai ae?aaiico i?iaiaeeeany o a?aeiia?aeiino? c
a?o/eciyiith eeaneo?eaoe??th a?iioieaaaiaaeo caoai?thaaiue o ae?oae oa
eiinainonii c ieoaiue AA (Ee?a, 1998) ?c a?aooaaiiyi ?acoeueoao?a
ee?i?ei-eaai?aoi?ieo, ?ino?oiaioaeueieo ? ooieoe?iiaeueieo iaoiae?a
aeine?aeaeaiiy.

Ianoaaeaiiy ioiiethaaei niaoe?aeuei? iaoiaee. Aeoeai?noue iaoaaie?cio
niieo/ii? oeaieie ioe?ithaaee oeyoii aecia/aiiy ienei?ie?io oa n?aeiaeo
eeneio o ne?iaaooe? e?ia? (A.A.Iaiueoeeia, 1987) oa ?oiaeiiiaeo aioeo?e
(N.A.Aaiainii e niaao., 1992).

I?ioeane a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a ioe?ithaaee ca ai?noii
iaeiiiaiai aeeaeueaeaa?aeo (IAeA) a e?ia? (E.Ae.Noaeueiay,
O.A.Aa?eoaeee, 1977). Aecia/aany ??aaiue oa?iaio?a aioeieneaeaioiiai
caoenoo – noia?ieneaeaeeniooace (NIAe) o aaiie?cao? (N.*aaa?e e niaao.,
1985), eaoaeace (E) a a?eo?ioeeoao (N.*aaa?e, O.Aiaeye, 1991),
oea?oeiieaci?io (OeI) a ieaci? ca ?aa?iii (1969),
noeoeeiaoaeaa?ae?iaaiace (NAeA) o ne?iaaooe? (?.A.Iao?inyi, 1971), a
oaeiae ai?no SH-a?oi (E.N.O?aaeia, 1972).

Aeine?aeaeaiiy ee?oeiiiai ?ioi?oaoo iieyaaei a ?aeaioeo?eaoe?? A-?OE,
AAN-?OE ca aeiiiiiaith niiioaiiiai ?icaoeiooai?aiiy ca Mendes o
iiaeeo?eaoe?? O.?.A??oeia, N.Itheea?a, A.O.O?ieiaa (1984). E?euee?noue
aeoeaieo O-e?ioioeeo?a (AA-?OE) aecia/aee ca iaoiaeii R.Smith oa
ni?aaaoi??a (1975) o iiaeeo?eaoe?? A.I.*a?aae??aa (1988).
Eiioeaio?aoe?y ?ioiiaeiaoe?i?a o ne?iaaooe? e?ia? (eean?a A, M, G)
anoaiiaeaia ca aeiiiiiaith ?aae?aeueii? ?ioiiaeeooc?? a aae? ca
G.Mancini (1965). Aecia/aiiy ?ioiiaeiaoe?io A i?iaiaeeeiny a ?aaeoe??
niiaeeaaiiy eiiieaiaioo (A.A.AEaeoaae, A.I.*aeioeei, 1978).
Eiioeaio?aoe?th oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) o ne?iaaooe?
e?ia? aecia/aee ca iaoiaeii V.Haskova o iiaeeo?eaoe?? TH.A.A??iaae/a
(1986). ??aaiue eiiieaiaioo aeine?aeaeoaaany oeyoii oeo?oaaiiy ca 50%
aaiie?cii (E.A.Ceeueaa?, 1968).

Aeeaeia aiaeiaaiii? ?ioieneeaoe?? ioe?ithaaeany ca ai?noii iieaeoe
na?aaeiuei? iane (INI) o e?ia? oa na/? ca iaoiaeii I.?.Aaa??aeyia,
A.?.E?iaoiaa (1984) i?e aeaio aeiaaeeiao oaee?: 254 ? 280 ii.

?acoeueoaoe aeine?aeaeaiue ii?aoeueiaai? noaoenoe/ii ca aeiiiiiaith
iaeaoa i?eeeaaeieo noaoenoe/ieo i?ia?ai ia ia?niiaeueiiio eiii’thoa??
IBM-486 PC/AT-100.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy.

Na?aae ianoaaeaieo oai?eo ?c AA o 72.7% iaoe??io?a ae?aaiinoiaaia
aoii?/ia oi?ia, o 27.3% – ?ioaeoe?eii-aea?a?/ia. Caaaeath/e ia
aeecuee?noue iaoiaaiaoe/ieo ? ee?i?/ieo oa?aeoa?enoee o?ii?/iiai
a?iio?oo oa aoi?eiii? o?ii?/ii? iiaaiii??, aiie aoee ia’?aeiai? a a?oio
o?ii?/ii? iaoieia?? (OI) eaaaiue. ?iciiae?e ae?oae ca iicieia?/ieie
iaeeieoeyie ni?aiaaea? c? no?oeoo?ith o?ii?/ii? oa ?aoeeaeeaoth/i?
iaoieia?? (O?I) i?aai?a aeeoaiiy (A.O.Iicaeaanueeee, 1991;
TH.E.Aieueaio, 1994; N.TH.Eaaaiia e niaao., 1998), aea aaaiii
ia?aaaaeathoue ?A oa AA. Na?aae iaoe??io?a oaea?/? a?eueoa aoei
oeii/ee?a (67.3%), ai?ae ae?a/aoie (32.7%).

Eiaeiee o?ao?e iaoe??io ?c O?I i?aai?a aeeoaiiy aoa o a?oe? 11-14 ?ie?a.
?iciiae?e oai?eo i?e eiaei?e ie?ai?e iicieia?/i?e oi?i? iaa nai?
caeiiii??iino?. Cie?aia, iieiaeio aeine?aeaeoaaieo ?c ?A neeaee ae?oe
aeioe?eueiiai a?eo, ia ui aeacothoue oaeiae ?io? aeine?aeieee
(?.I.Ea?thoeeia e niaao., 1993; A.O.Iicaeaanueeee, 1994). Iaoe??ioe c AA
aoee i?aaenoaaeai? aeaiia i?ia?aeieie a?eiaeie a?oiaie: aeioe?eueiyo
(35.1%) oa noa?oeo 10 ?ie?a (35.9%). Aiaeii/an, ne?ae iiaiaeeoeny c
aeoieith ie?aieo iaoeiaoe?a (O.A.Ia?oeaaa e niaao., 1994; A.A.Aiaaeaiiaa
? ni?aaao., 1998), eio?? aeacothoue ia iaaaeaeaaoio noaoenoeeo
caoai?thaaiino? AA na?aae ae?oae aeioe?eueiiai a?eo. Ae?enii, ?aoaeueiee
aiae?c oi?ioaaiiy AA a ianoaaeaieo aeyaea o?eaaeee ia??iae ianeoaaiiy
ae?aaiico i?ae ?ioeie. OI eaaaiue na?aae aeioe?eueiyo aoea
ae?aaiinoiaaia o eiaeiiai /aoaa?oiai oai?iai, a iaeaeua caoai?thaai?noue
cono??/aeany na?aae oeiey??a (74.7%), c ieo 66.2% – ae?oe, noa?o? 10
?ie?a.

On? o?e iicieia?/i? oi?ie O?I ia’?aeioaaei oa, ui c iiiaioo ?icoe?aiiy
eiea ni?eeoaaiiy ae?oae i?e a?aea?aeoaaii? aeeoy/eo caeeaae?a
(aeeonaaeie ( oeiea) aeiaeueiaoaaeany e?eaa ?inoo caoai?thaaiino? ?A,
OI, AA. Naia oeae a?eiaee ia??iae ? e?eoe/iei aeey i?aai?a aeeoaiiy e
?ioiii? nenoaie, a oiio, ia aeoieo aeayeeo aaoi??a (O.A.Aiae?eaae/,
1991; E.A.Miles et al., 1994; TH.A.Aaeeinueeee ? ni?aaao, 1998), oea
ni?ey? o?ii?caoe?? a?iioieaaaiaaiai i?ioeano.

No?oeoo?a O?I i?aai?a aeeoaiiy na?aae ianoaaeaieo oa?aeoa?ecoaaeany:
1) o aeiaaeeo AA ia?aaaaeaea aoii?/ia oi?ia (72.7%) oa na?aaeiueioyaeeee
ia?aa?a oai?iae (54.2%), a 1.6 ?ac?a /ano?oa oyaeeee ia?aa?a yaeooe
anoaiiaeaiee i?e ?ioaeoe?eii-aea?a?/i?e oi?i? AA; 2) na?aae ianoaaeaieo
?c OI o 23.1% aeiaaee?a ae?aaiinoiaaia aoi?eiia iiaaiii?y, ui
a?aeiia?aea? no/aniiio aa/aiith aeaii? i?iaeaie.

Iniiaio /anoeio aeine?aeaeoaaieo neeaee ae?oe c o?eaaeei ia?aa?aii
caoai?thaaiiy: aei 3 ?ie?a (26.1%), aei 5 ?ie?a (22.5%) oa aei 10 ?ie?a
(15.5%). Oea aea? i?aenoaae noaa?aeaeoaaoe i?i noi?iiaaio iaoieia?th,
eio?a oa?aeoa?eco?oueny iaaieie ee?i?/ieie iciaeaie. Oei ia/a, ui o
eiaeiiai i’yoiai iaoe??ioa caoai?thaaiiy aa?a ii/aoie o ?aiiueiio a?oe?.

Ia iiiaio anooio aei noaoe?iia?o noai 327 (59.4%) iaoe??io?a
a?aeiia?aeaa na?aaeiueioyaeeiio, 86 (15.5%) – oyaeeiio. I?ia?aeia
neiioiiaoeea o?aaeaiue na?aae ianoaaeaieo ia’?aeioaaeany ?ani??aoi?iei
neiae?iiii (82.6%), ianooiieie ca /anoioith aoee nea?ae ia i?enooie
yaeooe (48.4%), i?iyae ?ioieneeaoe?eiiai neiae?iio (28.9%).

Iiaia ee?i?/ia aeine?aeaeaiiy ae?oae aeaei ciiao iiai?noth aa?eo?eoaaoe
ee?i?/iee ae?aaiic oa ae?aaiinooaaoe noiooith iaoieia?th. O no?oeoo??
yei? aeae?eaii o?e i?ia?aei? a?oie (?en. 1). O aeiaaeeo AA oa ?A ia?oa
i?noea iin?aeaee naia aiaieua o?ii?/ii? ?ioaeoe??, c ia?aaaaith
eieae?caoe?? a iini?ioiaeiooe?, a i?e OI eaaaiue ?c iaea?eueoith
/anoioith cono??/aeany aaiaoia?e?a?ia iaoieia?y (?en. 1).

Iaaaeueia i?iaeaia no/anii? ioeueiiiieia?? a aoaeoeaieo caniaao
ae?aaiinoeee aeoeaiino? caiaeueiiai eiiiiiaioo oa aeeaeie aeenaaeaino
eieaaaiiooai?aiiy i?e ?aoeeaeeaoth/iio, o?ii?/iiio a?iioieaaaiaaiio
i?ioean?. Aaciina?aaeiuei oe? aeaa oaeoi?e aecia/athoue ia?aa?a O?I
eaaaiue. Ine?eueee iiaaiineea?ioe/i? ci?ie iiaeooue aeieeaoe i?ae ae??th
??ciiiai?oieo /eiiee?a oaea i?e ?aoeeaeeaoth/iio o?aaeaii?
a?iioieaaaiaai? nenoaie, a oaeiae ioiieththoue ia?o? eaiee caoyaeiiai
caiaeueiiai i?ioeano a eaaaiyo.

Aeine?aeaeaiiy ia?ea??a niieo/ii? oeaieie – ienei?ie?io, n?aeiaeo eeneio
(NE), ?oiaeiiiaeo aioeo?e (?iAo) c’ynoaaei, ui aeeaeia ?o aeenaaeaino
caeaaeaea a?ae oyaeeino? ia?aa?ao O?I. Cie?aia anoaiiaeaii, ui i?e an?o
iicieia?/ieo oi?iao aeinoia??ii c?inoa? ai?no ienei?ie?io a e?ia?, c
iaeneioiii o oai?eo ?c ?ioaeoe?eii-aea?a?/iith AA (48.2±1.7 ieiieue/e,
P<0.001) oa o?ii?/iei a?iio?oii (49.2±1.9 ieiieue/e, P<0.001). Aeniea iaoaaie?/ia aeoeai?noue ienei?ie?io c?inoaea a iine?aeiaiino? ?A(AA(OI ? aeiaiaeeea aeoeai?noue caiaeueiiai i?ioeano. Iaoii?noue, aecia/aiiy NE o e?ia? i?e an?o caoai?thaaiiyo aeyaeei ?o o?c?ieia?/iee ??aaiue (P>0.05), a oiio ia iaei ae??oaeueiiai cia/aiiy aeey ?ioa?i?aoaoe??
caiaeueiiai i?ioeano.

I?iaaaeaiiy aecia/aiiy ?iAo o e?ia? ae?oae ?c O?I i?aai?a aeeoaiiy
c’ynoaaei eiai aenieo ?ioi?iaoeai?noue. Iaeneiaeueiei ooai?aiiyi ?iAo
noi?iaiaeaeoaaeanue aeoeaaoe?y caiaeueiiai i?ioeano a iaoe??io?a ?c OI,
?o ??aaiue ia?aaeuoaaa iieacieee caei?iaeo o 2.4–2.6 ?ac?a. Caaino?aiiy
AA oa ?A ia?aa?aaei c aeoeaaoe??th neioaco ?iAo, ai?no yeeo aoa ?noioii
aenieei ? na?ae/ea i?i iineeaiee neioac eieaaaiiaeo no?oeoo? niieo/ii?
oeaieie oa ?? ?aia?aoeaii? ooieoe??. ??aaiue ?iAo ei?aethaaa ?c
aeeaeiith caiaeueiiai i?ioeano i?e O?I i?aai?a aeeoaiiy , ui
aeiaiaeeeiny ee?i?ei-eaai?aoi?ieie e?eoa??yie.

Ie??i oiai, ??aaiue ?iAo iaa caeaaei?noue a?ae aeoeaiino? aiaieu
o?ii?/ii? ?ioaeoe??, cie?aia EI?-i?aai?a. Oae, o ae?oae ?c ?A ??aaiue
?iAo nyaaa 24.8±0.7 oi.iae., oiae? ye i?e ii?aeiaii? c caaino?aiiyi
o?ii?/iiai neion?oo noaiiaea 32.5±0.6 oi.iae. (P<0.05). Oaeei /eiii, caaino?aiith O?I a?iioieaaaiaai? nenoaie a?aeiia?aea? iaeneiaeueia i?enei?aiiy ?aia?aoeaii? oa eieaaaiooai?thth/i? ooieoe?? niieo/ii? oeaieie. Ine?eueee ae?aaiinoiaaiee ?noioii aenieee ??aaiue ienei?ie?io, ui ? aeieacii iineeaiiai neioaco oa eaoaaie?cio eieaaaio aiaeii/an. Ae?aaiinoe/ia oe?ii?noue aecia/aiiy ienei?ie?io oa ?iAo iieyaa? a iiaeeeaino? ioa?aeoa?ecoaaoe aeeaeio caiaeaiiy oa aeaci?aai?caoe?? niieo/ii? oeaieie. Aeine?aeaeoaaio O?I i?aai?a aeeoaiiy o ae?oae ia’?aeio? ? a?iiene/iee neiae?ii, ui cae?enith? ??ciiieaiia? aieeae ia iieacieee aiiainoaco. Anoaiiaeaii, ui caaino?aiiy aeaii? iaoieia?? ii?aeio?oueny c aeoeaaoe??th a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a. Cie?aia, ai?no IAeA o e?ia? ?noioii ia?aaeuoaaa o?c?ieia?/iee (oaae. 1). O aeiaaeeo OI oa ?A ??aaiue IAeA ia?aaeuoaaa o 1.9-1.7 ?ac?a ii?io, a i?e AA – a?eueo, ye oaea?/?. Io?eiai? ?acoeueoaoe ocaiaeaeothoueny c ?iaioaie ?ioeo aeine?aeiee?a (O.A.Aaaeiaaeaaneay e niaao., 1991; A.O.Iicaeaanueeee ? ni?aaao., 1992; N.TH.Oa?auaiei, 1996) ? iiynith?oueny ooai?aiiyi aeoeaieo oi?i eenith ca oiia a?iien??. I?enei?aiiy i?ioean?a ia?ieneaeaoe?? e?i?ae?a aieeaa? ia ooieoe?iiaeueiee noai cania?a aioeieneaeaioiiai caoenoo (AIC). Aecia/aiiy ai?noo aicei?a ia?oi? e?i?? AIC c’ynoaaei, ui a iiiaio caaino?aiiy O?I i?aai?a aeeoaiiy aeieea? ?noioiee aeao?oeeo NIAe, NAeA, E (oaae. 1). Iaeneioi i?eai?/aiiy neioaco aioo??oiueiee?oeiieo oa?iaio?a o ii?aeiaii? c iaeaeuei ??aiai IAeA a e?ia? i?eoaiaii? AA. Aacoiiaii, oyaee?noue ia?aa?ao yaeooe, /ano? ?aoeeaeeae aecia/athoue aeeaeio a?iien??, a c oei ? nooi?iue c?ooaiue ia?ieneaeaoe?? e?i?ae?a. Ni?aa?aeiioaiiy i?ae ai?noii i?iaeoeo?a IIE oa aioo??oiueiee?oeiieo aicei?a i?e AA aeeaaea?oueny a iiiyooy oieiai? iaia?aiiiao??. O aeiaaeeo ?A ? OI eaaaiue oi?ioaaiiy a?iien?? i?eaiaeeoue aei aeniaaeaiiy cania?a ia?oi? e?i?? AIC, ui a?aeiia?aea? noaio iaia?aiiiao??. C iaoith ioe?iee aeoeaiino? aaaeeeaeo aicei?a ? ??aiy ia?ieneaeaoe?? e?i?ae?a aecia/aany oaeoi? aioeieneaeaioiiai noaio (N.*aaa?e, O.Aiaeye, 1991). I?e an?o oi?iao O?I a?iioieaaaiaai? nenoaie anoaiiaeaii ?noioia cieaeaiiy oaeoi?o a ii??aiyii? c iieacieeaie o caei?iaeo (?en. 2). Iaeiae iaeneiaeueii iecueeee oaeoi? aioeieneaeaioiiai noaio a?aeiia?aea? AA, ui ? na?ae/aiiyi iaea?iaaii? noeioeyoe?? a oiiaao a?iien?? a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a ona?aaeei? ee?oei. Ae?aaiinoiaaia iaia?aiiiao?y o oai?eo ?c O?I i?aai?a aeeoaiiy noi?iaiaeaeoaaeany iaaei??iei aea?eueiaiiyi n??eiai?nieo niieoe – SH-a?oi (oaae. 1). Aiie aieiae?thoue aioeieenethth/eie aeanoeainoyie, a oiio ?noioii aenieee ?o ai?no o ae?oae ?c AA, ?A, OI iineoue oa?aeoa? i?ioeae?? aeoeaaoe?? IIE. C?inoaiiy ai?noo SH-a?oi ? iane?aeeii ieeneaiiy n??eiai?nieo a?ee?a a oiiaao iaea?iaaiiai IIE. C oeeo oyaeaiue, ? i?aenoaae ?icoe?ithaaoe cia/aiiy SH-a?oi ye a?aeiia?aeue cania?a ae?oai? e?i?? AIC, ? ye oano aeoeaiino? caiaeueiiai i?ioeano. Aaaiiei oaeoi?ii i?ioeae?? ?i?oe?eiaaiiio IIE i?e caaino?aii? O?I i?aai?a aeeoaiiy aoa ??aaiue OeI, ui iaeaaeeoue aei o?aouei? e?i?? AIC (oaae. 1). OeI ia/a noai?th? caoenio iaieiieo, ui iaa??aa? a?eo?ioeeoe a?ae ?oei?aiiai aieeao oienei?a, ia?aeenieo niieoe, a?ieia?/ii aeoeaieo ?a/iaei, ui iio?aieythoue o e?iaiiinia ?onei c? ci?iaieo oeaiei /e i?e AA, /e i?e OI eaaaiue, /e i?e ?A. Ai?no OeI i?e an?o aeine?aeaeoaaieo oi?iao o 2.8 ?ac?a ia?aaeuoaaa NIAe, NAeA, E ? na?ae/eoue i?i oa, ui naia a?i a?ae?a?a? i?ia?aeio ?ieue o oi?ioaaii? caoenieo iaoai?ci?a a?ae iaaei??iiai iaeiie/aiiy iaaeiieeneaieo i?iaeoeo?a. Aieea ?ioaeoe?eieo ? ia?ioaeoe?eieo aaaio?a, oienei?a, a?iien?? i?e o?ii?/iiio /e ?aoeeaeeaoth/iio a?iioieaaaiaaiio i?ioean? aaaea aei iineeaiiy a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a ee?oeiieo iaia?ai, i?eai?/aiiy aioeieneaeaioieo oa?iaio?a, ui noi?iaiaeaeo?oueny iaeiie/aiiyi aea?eaao?a IIE, ye? cae?eniththoue oeeoioiene/iee aieea ia a?iiaia?aie. Aiaeii/an, aeoeai? oi?ie eenith, ui ooai?ththoueny i?e o?eaae?e a?iien??, caeaoi? ?iaeoeoaaoe i?ioeane IIE. Ee?i?/i? iniaeeaino? ia?aa?ao ?A, OI, AA cia/iith i??ith caeaaei? a?ae noaio ?ioiieia?/ii? ??aiiaaae i?aai?cio aeeoeie. I?iaaaeaiiy ?ioiieia?/iiai aeine?aeaeaiiy c’ynoaaei, ui caaino?aiiy o?ii?/iiai a?iio?oo oa aoi?eiii? o?ii?/ii? iiaaiii?? o aeioe?eueiyo ii?aeioaaeiny c iaea?eueoei i?eai?/aiiyi aeoeaiino? ee?oeiiiai ?ioi?oaoo. Aoi?eiiee ee?oeiiee ?ioiiaeao?oeeo o oai?eo ia AA iieyaaa o ciaioaii? A-?OE ? AA-?OE (P<0.001), a oaeiae aeao?oeeo? oaio?e?i/ooeeaeo ee?oei. Aeao?oeeo ? nooiaiy na?aae aeioe?eueiyo aeyaeaiee: i?e aoii?/i?e AA – o 69.4% , ?ioaeoe?eii-aea?a?/i?e – o 75.0% aeiaaee?a; a na?aae oeiey??a: i?e aoii?/i?e – o 58.8% , ?ioaeoe?eii-aea?a?/i?e – o 70.5% oai?eo. Aiaeii/an c?inea e?euee?noue ae?oae ?c AA noa?oa 6 ?ie?a, o eio?eo ae?aaiinoiaaiee ?ioiiaeao?oeeo ee?oeiii? eaiee ?ioi?oaoo ?? nooiaiy: aoii?/ia – 41.1%, ?ioaeoe?eii-aea?a?/ia – 29.4%. Iiaeeaeaiiy ?ioiiaeao?oeeoo o oai?eo oe?eueiiai a?eo iiynith?oueny a?oiith oaeoi??a: a?eueoa o?eaae?noue caoai?thaaiiy, aenieee ?iaeaen aiaieu o?ii?/ii? ?ioaeoe??, noiooiuei? iaoieia?? c aieo aioo??oi?o i?aai?a. O oe?eiio, iniiaiei i?e/eiii-cia/eiei iiiaioii aoei iiaeeaeaiiy yaeu a?iien??, ui i?eoaiaiia AA ye o?ii?/iiio caoai?thaaiith. Noai ee?oeiiiai ?ioi?oaoo o iaoe??io?a ?c ?A caciaa cia/ii iaioeo ci?i o ii??aiyii? c AA /e OI. Cie?aia, cieaeaiiy A-?OE, AA-?OE (P<0.001) oa ii?ooaiiy ni?aa?aeiioaiiy i?ae ie?aieie noaiiioeyoe?yie na?aae aeioe?eueiyo o 88.4% aeiaaee?a a?aeiia?aeaei ?ioiiaeao?oeeoo ? nooiaiy, a na?aae oeiey??a – o 81.2% oai?eo. Ae?aaiinoiaaiee aoi?eiiee ?ioiiaeao?oeeo ee?oeiii? eaiee ?ioi?oaoo a ae?oae ?c O?I noi?iaiaeaeoaaany ci?iaie c aieo aoii?aeueii? eaiee. Ni?eueiei aeey o?ii?/ieo ? ?aoeeaeeaoth/eo caoai?thaaiue i?aai?a aeeoaiiy aoei aeoeaaoe?y neioaco Ig M, i?e oeueiio a?i aoa ?noioii aenieei o iiiaio caaino?aiiy (P<0.001). A?ia?i?iaeoeoe?y Ig M iiynith?oueny iecueeei ??aiai Ig G (P<0.05) oa i?e?iaiei iaecaaeai aeeoaeueieo oeyo?a i?e eiaei?e ie?ai?e iicieia?/i?e oi?i?, ia ui aeacothoue ? ?io? aeine?aeieee (E.I.Iia?iaa e niaao., 1991; N.I.Aaaaeia e niaao., 1992; M.V.Konstan et al., 1994). Iaeiae oaea aeen?ioiiaeiaoe?iai?y a cia/i?e i??? caeaaeia a?ae neioaco Ig A, ui e iaoiiaeth? niaoeeo?eo eiaeii? ie?aii? iaoieia??. Ia?aaeon?i o oai?eo ia aoii?/io AA aeioe?eueiiai a?eo ??aaiue Ig A aoa ?noioii iecueeei (P<0.01). Cieaeaiiy ai?noo Ig A a e?ia? ? iane?aeeii ia eeoa o?ii?/iiai caiaeaiiy, aea e ?aoeeaeeaiiai oa?aeoa?o AA, ui a oe?eiio ni?eyei aeoea?caoe?? iaoai?ci?a neioaco Ig E. ??aaiue Ig E ?noioii aenieee (P<0.001), ui iineeth?oueny aeeeaeii a?ieia?/ii aeoeaieo ?a/iaei o e?iaiiinia ?onei a ia??iae caaino?aiiy. O aeiaaeeo OI i?aai?a aeeoaiiy a?ia??ioiiaeiaoe?iai?y I coiiaeaia iecueeei ??aiai Ig G (P<0.01) ia oii? aeao?oeeoo Ig A (P<0.05), ui aeiaiaeeoue ?ioaeoe?eiee aaiac o?ii?/iiai caiaeueiiai i?ioeano. Iaoii?noue na?aae iaoe??io?a ?c ?A aenieee ??aaiue Ig M ae?aaiinoiaaiee o aeioe?eueiyo ia oii? aeao?oeeoo Ig A (P<0.05), a o oeiey??a i?e noaii?iaeueiiio ai?no? Ig A, ui ni?e/eiaii a?eiaeie aniaeoaie ?ioiii? nenoaie o ae?oae. Aiae?coth/e eiioeaio?aoe?th Oe?E o e?ia? iaoe??io?a ?c O?I i?aai?a aeeoaiiy, aeyaeaii, ui caaino?aiiy caiaeueiiai i?ioeano anioe?thaaeiny c i?aeaeuaiiyi Oe?E o 2.3-3 ?ace. Aiii iaoiiaethaaei aeoeaaoe?th nenoaie eiiieaiaioo c iineeaiei eiai niiaeeaaiiyi, a oiio ai?no eiai ciaioeany a 1.6-2.1 ?ace. Ocaaaeueithth/e io?eiai? aeai?, ye? aeaiiino?othoue noeoii?noue aeieac?a niioai?aiiai iaoaaie?cio a iiiaio caaino?aiiy O?I i?aai?a aeeoaiiy, aeieea? ?aaeueia iio?aaa c’ynoaaoe iniaeeaino? aiaeioienai??. O ?iaio? aeei?enoaia iaoiaeeea aecia/aiiy INI o o?ueio a?ieia?/ieo nenoaiao (a?eo?ioeeoe, ieacia, na/a), ui aeaei iiaeeea?noue ioe?ieoe ia eeoa ??aaiue iaeiie/aiiy i?ii?aeieo ? e?ioeaaeo i?iaeoeo?a, a e iiaeeea? oeyoe ?o aeaaaeaiiy. Anoaiiaeaii, ui caaino?aiiy OI ? AA o ae?oae (iacaeaaeii a?ae a?eo) noi?iaiaeaeo?oueny ?noioiith aiaeioienai??th ca ?aooiie aenieiai ai?noo INI iaio ioe?a o a?eo?ioeeoao (P<0.001) oa ieaci? (P<0.05-0.01). Iaeii/anii c’yniaaia ?noioia o?eueo?aoe?y INI ?c na/ath (P<0.05-0.001), eio?a ? iaaeinoaoiueith aeey e?ea?aeoaaiiy aenieeo eiioeaio?aoe?e oiene/ieo niieoe ?c e?ia?. O oe?eiio oea na?ae/eoue i?i oa, ui caaino?aiiy AA ? OI noi?iaiaeaeo?oueny noaae??th cai?ioiuei? aeaeiiiainaoe?? aiaeiaaiii? ?ioieneeaoe??. Caaino?aiiy ?A o ae?oae niiioea? aei aeieeiaiiy aiaeioienai?? ca ?aooiie ?noioii aenieeo ??ai?a INI (P<0.001) a a?eo?ioeeoao i?e noaii?iaeueiiio ?o ai?no? o ieaci? (P>0.05) oa ii?aeio?oueny c o?c?ieia?/iith o?eueo?aoe??th oienei?a ?c
na/ath. Aacoiiaii, oaeee ia?a?iciiae?e INI o a?ieia?/ieo na?aaeiaeuao
na?ae/eoue ia ei?enoue aeaeiiiainiaaiiai aiaeioienai??.

Iaaaaeai? aeai? ?ethno?othoue ee?i?/ii iaeiiai?oanoio aiaeiaaiio
?ioieneeaoe?th o oac? caaino?aiiy AA, ?A, OI, ui iineoue
aeaeiiiainiaaiee oa?aeoa?. Aeeaeia aiaeioienai?? caeaaeeoue a?ae
i?ia?aeiiai ao?iiaoiaaiaoe/iiai /eiieea (i?e ?ioaeoe?eiiio oa?aeoa?? –
aiia a?eueoa), oyaeeino? noaio aeeoeie (ia i?aenoaa? aeaieo i?e AA, OI),
ooieoe?iiaeueii? ni?iiiaeiino? i?e?iaei?o aeaoieneeoth/eo nenoai oa
nooiaiy aeeniaoaaie?/ieo c?ooaiue. Aeieacii inoaiiueiai ? ei?aeyoe?ei?
ca’ycee i?ae ai?noii INI ? aeine?aeaeoaaieo ia?aiao??a o oai?eo ae?oae.

O aeiaaeeo ?A anoaiiaeai? i?yi? o?ni? ei?aeyoe?ei? ca’ycee i?ae ai?noii
INI2 a a?eo?ioeeoao oa ??aiai ?iAo (r=0.602), Oe?E (r=0.687), Ig M
(r=0.541), a cai?ioi? – c e?euee?noth A-?OE (r=-0.562), eiiieaiaioii
(r=-0.678), NIAe (r=-0.802), c eiioeaio?aoe??th IAeA (r=0.784).

I?ia?aei? ei?aeyoe?ei? ca’ycee i?e caaino?aii? OI aoee i?aaenoaaeai?:
o?nieie i?yieie i?ae ai?noii INI2 o ieaci? ? ??aiai ?iAo (r=0.595), Oe?E
(r=0.598), Ig M (r=0.798); a oaeiae i?ae e?euee?noth INI2 a a?eo?ioeeoao
? IAeA (r=0.715), eiiieaiaioii (r=-0.561), NIAe (r=-0.643).

I?e iaio oi?iao AA anoaiiaeaia i?yia ei?aeyoe?eia caeaaei?noue i?ae
??aiai INI2 ieacie oa SH-a?oiaie (aoii?/ia: r=0.847,
?ioaeoe?eii-aea?a?/ia: r=0.783), Oe?E (a?aeiia?aeii: r=0.649 ? r=0.971);
cai?ioiy caeaaei?noue i?ae INI2 a?eo?ioeeo?a ? NIAe (a?aeiia?aeii:
r=-0.582, r=-0.534), eiiieaiaioii (a?aeiia?aeii: r=-0.548, r=-0.699), a
i?yia – c ??aiai IAeA (a?aeiia?aeii: r=0.729, r=0.716). A?aei?iieie
aoee: o?niee i?yiee ei?aeyoe?eiee ca’ycie i?ae INI2 ieacie ? OeI
(r=0.527) i?e aoii?/i?e AA, a oaeiae i?yia caeaaei?noue i?ae INI2 ieacie
? ?iAo (r=0.720) i?e ?ioaeoe?eii-aea?a?/i?e oi?i?. Ae?aaiinoiaai?
aca?iicaeaaeiino? aeiiiaiththoue aeeoa?aioe?eio oa?aeoa?enoeeo aeaio
oi?i yaeooe. C oeeo oyaeaiue aeoeai?noue OeI anioe?th?oueny c
aeoeaaoe??th aea?a?/iiai caiaeaiiy, ui noi?iaiaeaeo?oueny aea?eueiaiiyi
a?ieia?/ii aeoeaieo ?a/iaei, eio?? ca?eueoothoue aenoeioe?th INI o
ieaci?.

Iaoii?noue, i?e ?ioaeoe?eii-aea?a?/i?e AA aeoeaaoe?y o?ii?/iiai
caiaeaiiy anioe?th?oueny c ?noioieie c?ooaiiyie iaoaaie?cio
niieo/iioeaieiieo aeaiaio?a, i?iaeoeoe yeiai aieeaathoue ia ??aaiue
aiaeiaaiii? ?ioieneeaoe??. Naia oeei iiynith?oueny o?niee i?yiee
ei?aeyoe?eiee ca’ycie i?ae INI2 ieacie oa ??aiai ?iAo (r=0.720).

Iiaia oa?aeoa?enoeea aeeaeie caiaeueiiai i?ioeano i?e O?I i?aai?a
aeeoaiiy ia?aaeaa/a? a?iioineii?/ia aeine?aeaeaiiy. A?iioineii?y c
ianooiiei aeine?aeaeaiiyi a?iioiaeueaaiey?iiai cieao i?iaaaeaia 78
iaoe??ioai, ye? a?ae?a?ai? ca /?oeeie iieacaie. Aeeaeia aiaeia?iio?oo
aecia/aeany ca?aeii c ?nioth/ith eeaneo?eaoe??th (A.A.Eeeiaineay e
niaao., 1992).

Iaea?eueo /anoith oi?iith aoa eaoa?aeueii-ai?eiee aiaeia?iio?o (55.1%).
O eiai no?oeoo?? aaaiia i?noea caeiaee iaoe??ioe c OI (48.8%) oa AA
(25.5%). Ianooiiei aoa ai?eiee aiaeia?iio?o (24.3%), yeee
noi?iaiaeaeoaaa caeaa?eueoiai caaino?aiiy OI (63.1%) aai
?ioaeoe?eii-aea?a?/ii? oi?ie AA (26.3%). Ieoiia aaaa eaoa?aeueiiai
aiaeia?iio?oo neeaea 20.5% aeiaaee?a, aoea oa?aeoa?ia aeey AA (56.2%) oa
?A (31.2%).

Oaeei /eiii, iaea?eueo iioe?aiei i?e caaino?aii? O?I aoa
eaoa?aeueii-ai?eiee aiaeia?iio?o. Ii a?aeiioaiith aei no?oeoo?e aeaiiai
aiaeia?iio?oo, oi ne?ae a?aei?oeoe eiai aenieo /anoioo na?aae ae?oae ?c
AA. Ia ??no eaoa?aeueii-ai?eiiai aiaeia?iio?oo o iaoe??io?a ?c yaeooith
caa?ioee oaaao e ?io? aeine?aeieee (A.B.Kay, 1991; N.I.Aaaaeia, 1992;
A.O.Iicaeaanueeee, 1996), ui ? iani?eyoeeai i?iaiinoe/iith iciaeith.
Ine?eueee aeaia aeeaeia caiaeueieo ci?i o neecia?e a?iio?a na?ae/eoue
i?i iaaeinoaoith ooieoe?iiaeueio ni?iiiaei?noue i?noeaaeo iaoai?ci?a
?ioiieia?/iiai caoenoo (B.M.Kershengolts et al., 1997), ii?ooaiiy
ae?aiaaeii? oa aaaeoaoi?ii? ooieoe?e a?iio?a (A.A.Eeeiaiia e niaao.,
1991; A.A.Eeeiaineay e niaao., 1999). Iaeiae, iaiao?aeii caoaaaeeoe, ui
a?iioineii?y, a iniiaiiio, aeeiioaaeany ae?oyi ?c
?ioaeoe?eii-aea?a?/iith oi?iith yaeooe oa ca oiia ai?eiiai
aiaeia?iio?oo. Aacoiiaii, oe? ianoaaeie aecia/eee nooi?iue caiaeaiiy
neeciai? a?iio?a.

Ianoi?iaeo? ? oa ianoaaeia, ui o eiaeii? aeaa’yoi? aeeoeie c ?A
ae?aaiinoiaaiee ai?eiee aiaeia?iio?o. Ai?eiee aiaeia?iio?o o iaoe??io?a
?c AA aoa aeyaeaiee o?eueee i?e ?ioaeoe?eii-aea?a?/i?e oi?i?.

?ioaeoe?ei? /eiieee iaee aieea ia aeeaeio caiaeueieo yaeu. Ca aeaieie
aaeoa??ieia?/iiai aeine?aeaeaiiy ai?noo a?iio?a, aeii?ioth/ith aoea
eieiaa oei?a. I?e eaoa?aeueii-ai?eiiio aiaeia?iio?o? aen?aaeeny
noao?eieiee (41.8%) oa no?aioieiee (39.5%). Ai?eiee oa?aeoa?
aiaeia?iio?oo aoa aeeeeeaiee eieiaith oei?ith oa o 18.6% aeiaaee?a – P.
aeruginosa.

Iaeiae, a?coaeueia oa?aeoa?enoeea nooiaiy aiaeia?iio?oo ? a?aeiiniith,
ine?eueee caeaaeeoue a?ae eiiiaoaioiino? e?ea?y-a?iioieiaa. C oeeo
i??eoaaiue aoa aeei?enoaiee AAE, yeee nai?i a?io?i?/ii-?ioiieia?/iei
niaeo?ii aeiiiaithaaa aiaeineii?/io ea?oeio (oaae. 2).

Ca aeaieie AAE, anoaiiaeaii, ui eaoa?aeueiiio aiaeia?iio?oo (? nooiaiy)
oa?aeoa?i?: i?aeaeuaiee ai?no Ig G, caaaeueiiai a?eea, n?aeiaeo eeneio,
e?cioeeio i?e o?c?ieia?/ieo – Ig M ? Ig A. I?i?iaeuei? i?iyae
caiaeueiiai oa?aeoa?o iaoiiaeai? aeae?eueeiia iaoai?ciaie: 1) aenieith
e?cioeeiiith aeoeai?noth a?iio?aeueiiai nae?aoo (o 6.7 ?ac?a
ia?aaeuoaaea ii?io); 2) a?ia?i?iaeoeoe?y NE oa a?eea (o 2.5 ?ac?a)
niiioeaea aei ooai?aiiy n?aeiiooeei?a; 3) aenieee oeo? aioeo?e eeano
Ig G i?e o?c?ieia?/iiio – Ig A caaacia/eee ea?iaaiee oa?aeoa? caiaeaiiy.
Aiaeii/an, oea iiynith? neecenoee oa?aeoa? ai?noo a?iio?a.

Eaoa?aeueii-ai?eiiio aiaeia?iio?oo i?eoaiaii?: ca?eueoaiiy a 2.5 ?ace
ai?noo Ig G, aeao?oeeo Ig A i?e ii?iaeueiiio ??ai? Ig M; c?inoaiiy
ao?e/? ai?noo a?eea, oaea?/? – NE, o 3.6 ?ace – e?cioeeio, o ii??aiyii?
c eiio?ieueiith a?oiith (oaae. 2). I/aaeaeiei ? c?inoaiiy cia/aiiy
?ioaeoe?eiiai oaeoi?o o iiaeeaeaii? caiaeueieo ci?i ia oii? aeniaaeaiiy
i?e?iaei?o iaoai?ci?a caoenoo, cie?aia neioaco Ig A. Iacaaaeath/e ia oa,
ui ??ai? NE, e?cioeeio ?noioii aenie?, aiie ieae/? ca aiaeia?/i? i?e
eaoa?aeueiiio aiaeia?iio?o? (P<0.05). Aiaeii/an, ae?aaiinoiaaiee a?eueoee ai?no a?eea, ui iiynith? a?eueoo e?euee?noue a?iio?aeueiiai nae?aoo i?e a?coaeuei?e ioe?ioe? eaoa?aeueii-ai?eiiai aiaeia?iio?oo. Aeenaaeain i?ae iieacieeaie niaoeeo?/iiai oa ianiaoeeo?/iiai caoenoo iaoiiaea neecenoi-ai?eiee oa?aeoa? ai?noo a?iio?a. ?ioii-a?io?i?/iee i?io?eue ai?eiiai aiaeia?iio?oo (oaae. 2) oa?aeoa?ecoaaany: ao?e/? ca?eueoaiei ??aiai Ig G, oaiaeaioe??th aei c?inoaiiy Ig M, ae?aaeaiei aeao?oeeoii Ig A, c?inoaiiyi o 7.5 ?ac?a ai?noo a?eea, i?e o?c?ieia?/iiio ai?no? NE oa e?cioeeio. Ai?eiee oa?aeoa? a?iio?aeueiiai ai?noo aoa iaoiiaeaiee a?aenooi?noth caoeniiai neioaco aioeo?e eeano Ig A, ui ni?eyei aeoea?caoe?? i?iaeoeoe?? aioeo?e eeano Ig M. Ie??i oiai, iioe?aiith a?iio?aeueiiai caiaeaiiy ia iiaee i?ioeae?yoe noaii?iaeuei? ??ai? ianiaoeeo?/ieo oaeoi??a ?ioiieia?/iiai caoenoo. Aiaeii/an, a?ia?i?iaeoeoe?y a?eea a oiiaao ?ioiiaeao?oeeoo Ig A niiioeaea aei iiyae aaeeei? e?eueeino? a’yceiai, ai?eiiai oa?aeoa?o oa?eioeiiy. I?e eaoa?aeueiiio aiaeia?iio?o? i?iieeeea?noue noaeeiii-oeaieiiiai aa?’??o ca?eueoo?oueny, ui i?ecaiaeeoue aei iineeaiiy o?ainnoaeaoe?? ? ia?aoiaeo a a?iio?aeueiee nae?ao a?ee?a. O i??o i?ia?anoaaiiy caiaeueiiai i?ioeano a a?e ai?eiiai aiaeia?iio?oo, ai?no a?eea o AAC ?noioii c?inoa? (P<0.001). Oaeei /eiii, o oiae? aeine?aeaeaiiy anoaiiaeaii, ui a i??o i?ia?anoaaiiy caiaeueiiai i?ioeano a a?iio?aeueiiio aea?aa? aeieeathoue “iiaeeoe?”: iineeaiiio neioaco a?eea, Ig G, Ig M a?aeiia?aea? i?eai?/aiiy oaeoi??a caoenoo: Ig A, NE, e?cioeeio. Aa?o/e aei oaaae aaaaoia?aii?noue ae?aaiinoiaaieo c?ooaiue aiiainoaco, aoee ai?iaiaai? aeeoa?aioe?eiaai? noaie e?eoaaiiy. Aei ? a?oie aa?eoee oai?? ia O?I aeeoaeueii? nenoaie, ye? io?eioaaee oa?ai?th ca?aeii caaaeueiiaeciaieo noai e?eoaaiiy eiaeii? ie?aii? iicieia?/ii? oi?ie. Aei a?oie aa?eoei 126 ae?oae: 80 no?aaeaeaee AA, 20 – OI, 26 – ?A. Ae?oao a?oio neeaee 128 oai?eo (?c AA – 75 ae?oae, ?c OI – 21, c ?A – 32 ae?oae), eio?ei o?aaeeoe?eia e?eoaaiiy aeiiiaithaaeiny ei?ioeei eo?nii aioa?ini?aoe?? (5-7 aei?a). Oaea ei?aeoe?y e?eoaaiiy iaoiiaeaia aenieith /anoioith ae?aaiinoiaaii? aiaeiaaiii? ?ioieneeaoe?? na?aae ae?oae ?c o?ii?/ieie a?iioieaaaiaaeie caoai?thaaiiyie. Aioa?ini?aaio ea?ainoa? aeicoaaany c ?ic?aooieo 0.2 a/ea iane o?ea ia aeiao, o 3-4 i?eeiie, /a?ac 40-60 oaeeei i?ney i?eeiio e?e?a /e ?ae?. Aioa?ini?aoe?y ia noi?iaiaeaeoaaeany aoaeue-yeeie iia?/ieie ae?yie, aeia?a ni?eeiaeany ae?oueie. O?aoy a?oia (n=97: AA – o 60, OI – o 13, ?A – o 24 ae?oae) ioiiethaaea ianooiio noaio e?eoaaiiy: aacenia oa?ai?y aeiiiaithaaeanue aioa?ini?aoe??th (ca?aeii aeuaiaaaaeaiiai aeicoaaiiy), a aeae? aaeeaaiiyi ?eaieneio. ?eaienei – ?eaioo?aiiceea?iienaioei (?a?no?aoe?eiee iiia? – 78/868/10). Aaeeaaiiy ?eaieneio o ae?oae ia noi?iaiaeaeoaaeany aoaeue-yeeie iia?/ieie i?iyaaie. I?aia?ao i?ecia/aany o oaaeaoiaai?e oi?i?, c ?ic?aooieo 0.02 a/ea iane o?ea/aeiao, i?ioyaii 2 oeaei?a. Aei /aoaa?oi? a?oie (n=100: AA – 50, OI – 19, ?A – 31) a?aeianai? iaoe??ioe, eio?ei i?iaiaeeany eo?n e?eoaaiiy: ia oii? aacenii? oa?ai?? eiiieaen aioa?ini?aoe?y + ?aoi?ioai. ?aoi?ioai – i?ii?iiiaa eeneioa (?a?no?aoe?eiee iiia? – 82/374/12), ui ia? i?ioecaiaeueio ae?th. I?ecia/aany c ?ic?aooieo 15-20 ia/ea iane/aeiao, o 3 i?eeiie, i?ioyaii 2 oeaei?a. ?aoi?ioai aeia?a ia?aiineany oa ia noi?iaiaeaeoaaany aoaeue-yeeie iia?/ieie aoaeoaie na?aae ianoaaeaieo, o oiio ae /ene? o aeiaaeeo AA. Ca?aeii iieiaeaiue oa?iaeiia?, ?aoi?ioai ia ?aeiiaiaeo?oueny aaeeaaoe i?e AA, iaeiae o oiae? aeine?aeaeaiiy ia aoei aeyaeaii ani??eiiai? oi?ie yaeooe, ui e caaacia/eei a?aenooi?noue oneeaaeiaiue. Ae?oe, eio?? a eiiieaeni?e oa?ai?? o?ii?/iiai a?iioieaaaiaaiai caoai?thaaiiy io?eioaaee 5-7-aeaiiee eo?n aioa?ini?aoe??, a oaeiae e?iinoaa?e (?a?no?aoe?eiee iiia? – 414244/07.93), oa?eoee aei V a?oie oai?eo (n=79: c AA – 40, OI – 18, ?A - 21). Aeei?enoiaoaaany aioo??oiueiaaiii e?aieeiii, ia o?c?ieia?/iiio ?ic/ei? NaCl, i?e oeueiio e?iinoaa?e aeicoaaany c ?ic?aooieo 0.1-0.2 ie/ea iane/aaaaeaiiy, 1 ?ac ia aeaiue, i?ioyaii 5-7 aei?a. Canoinoaaiiy i?aia?aoo ia aeeeeeaei oneeaaeiaiue /e iia??oaiiy noaio oai?iai. Ioe?iea aoaeoeaiino? aeei?enoaieo iaoiae?a e?eoaaiiy aacoaaeany ia aiae?c? aeeiai?ee ee?i?/ieo neiioii?a, aeaieo eaai?aoi?ii-?ino?oiaioaeueieo iaoiae?a ianoaaeaiiy. Cie?aia, na?aae ae?oae, eio?? io?eioaaee caaaeueiii?eeiyoo oa?ai?th (? a?oia), iie?auaiiy naiiii/oooy niinoa??aaeinue o e?ioe? ia?oiai – ia ii/aoeo ae?oaiai oeaeiy. Oae, i?enooiiee ia??iae i?e aoii?/i?e oi?i? o?eaaa 3.2±0.7 aei?a, a i?e ?ioaeoe?eii-aea?a?/i?e AA – 3.7±0.8 aei?a. O 24.1% oai?eo i?enooie yaeooe a?aeiiaethaaeenue o noaoe?iia??, caeaa?eueoiai ia ae?oaiio oeaei? ia?aaoaaiiy. O aeai?e a?oi? o?eaaei oo?eioaaeeny nea?ae ia eaoaeue. Cie?aia, i?e aoii?/i?e oi?i? AA – 15.3±1.2 aei?, a i?e ?ioaeoe?eii-aea?a?/i?e – 16.8±2.9 aei?a, ui iaoiiaeaii a?eueo ae?aaeaiei aiaeia?iio?oii. O?eaae?noue iaoieia?/ieo aoneoeueoaoeaieo aeaieo c aieo eaaaiue i?e aoii?/i?e AA – 13.2±1.1 aei?a, a i?e ?ioaeoe?eii-aea?a?/i?e oi?i? – aiie oo?eioaaeenue 11.8±1.8 aei?a. Ee?i?/i? iciaee aiaeioienai?? ciaiooaaeeny ia ae?oaiio, cieeaee – ia o?aoueiio oeaei? noaoe?iia?iiai e?eoaaiiy. O eiaeii? /aoaa?oi? aeeoeie i?e aeienoe? oo?eioaaeanue aiceiio?e?y (7.4±2.1%), a o 10.8% aeiaaee?a – iaee/eiyaea?iee cnoa eaeeioi?ioee ae?ai ca aeaieie aaiia?aie. Na?aae oai?eo ia OI ?ani??aoi?iee neiae?ii aoa iaea?eueo o?eaaeei – 21.7±5.2 aei?a (P<0.05), iaa i?noea eaoaeue, a i?ioyaii 20.2±5.1 aei?a aeneooiaoaaeeny aieia? o?eie. Naiiii/oooy ae?oae o aeai?e a?oi? iie?auoaaeiny niia?eueiaii, caeaa?eueoiai a e?ioe? ae?oaiai oeaeiy. Ca aeaieie aaiia?aie, o 19.5% ae?oae ia iiiaio aeienee oo?eioaaany iaee/eiyaea?iee cnoa eaeeioeeoa?ii? oi?ioee. Ocaaaeueithth/e aeai? aoaeoeaiino? o?aaeeoe?eiiai e?eoaaiiy, anoaiiaeaii, ui iaea?eueoeo coneeue iio?aaoaaee ae?oe c OI eaaaiue, eio?? ciaoiaeeeeny ia noaoee?eoaaii? i?ioyaii 24.4±5.8 aei?a. Iaeoaeaeoa ee?i?/iee aoaeo aoa aeinyaiooee o ae?oae ?c ?A (18.7±3.8 aei?a). I?iaaaeaia e?eoaaiiy ca aeeoa?aioe?eiaaieie noaiaie ni?eyei oaeaeoiio cai?ioiueiio ?icaeoeo ee?i?/ii? neiioiiaoeee. Cie?aia, aaea i?e aaaaeaii? a eiiieaen oa?ai?? aioa?ini?aoe?? (?? a?oia) c 3-4 aeiy iie?auoaaeiny naiiii/oooy, nei?i/oaaeany o?eaae?noue ?ani??aoi?iiai neiae?iio, iai?eeeaae, i?e ?A ia 2.8±0.8 aei?a; o 89.7% oai?eo aeinyaiooi ii?iae?caoe?? ai?noo aiceiio?e?a o aaiia?ai?. O oe?eiio oea caaacia/eei nei?i/aiiy oa?i?i?a ia?aaoaaiiy a noaoe?iia?? (oaae. 3). Aeei?enoaiiy ianooiieo noai e?eoaaiiy (???–V a?oie) noi?iaiaeaeoaaeiny i?enei?aiiyi i?ioean?a aeaeoaeaiiy. A naia, i?e AA, ?A ? OI o?eaae?noue neiioii?a ?ani??aoi?iiai neiae?iio nei?ioeeany oaea?/? ? a?eueoa, iaoieia?/i? aoneoeueoaoeai? aeai? a eaaaiyo oo?eioaaeeny ia 5-7 aei?a ei?iooa. Iaeiae, iacaeaaeii a?ae oi?ie O?I aeeoaeueii? nenoaie, iaeneiaeueii ei?ioei oo?aoaaee nea?ae oa aecia/aeeny iaoieia?/i? o?c?eaeuei? aeai? c aieo a?iioieaaaiaaiai eiiieaeno a iaoe??io?a, ye? io?eioaaee noaio c aeei?enoaiiyi e?iinoaa?eo (V a?oia). O ae?oae, ui aa?eoee aei ???, IV, V a?oi, i?ae aieeaii aeeoa?aioe?eiaaieo iaoiae?a e?eoaaiiy nei?i/oaaeeny oa?i?ie ia?aaoaaiiy a noaoe?iia?? (oaae. 3). Ca aeaieie niaoeeo?/ieo iaoiae?a aeine?aeaeaiiy, anoaiiaeaii, ui ia oii? aacenii? oa?ai?? niia?eueithaaeeny i?ioeane ia?ieneaeaoe?? e?i?ae?a. Aeieacii /iai aoei cieaeaiiy ??aiy IAeA a e?ia? i?e an?o iicieia?/ieo oi?iao (? a?oia), iaeiae, cia/aiiy ?noioii ia?aaeuoaaee iieacieee o caei?iaeo. I?e oeueiio, iaeaeuee ai?no IAeA aeyaeaiee o oai?eo ?c ?ioaeoe?eii-aea?a?/iith AA (4.6±0.2 ieiieue/e, P<0.05) oa OI (4.5±0.2 ieiieue/e, P<0.05). Oea, ciiao ae oaee, ia?aeiio? o oiio, ui i?enooi yaeooe, aiaieua ?ioaeoe?eiiai i?ioeano aeeeeeathoue iaeneiaeueia ca?aeiaiiy caaacia/aiino? eeniai ee?oei, a c oeei – ?i?oe?ththoue ia?a?iaeaeaiiy e?i?aeiiai neeaaeo ee?oeiieo iaia?ai. Io?eiai? aeai? ocaiaeaeothoueny c ?acoeueoaoaie ?ia?o, o yeeo ae?aaiinoiaaia i?enei?aiiy i?ioean?a ia?ieneaeaoe?? a ia??iae ?aeiiaaeanoeaioe?? O?I i?aai?a aeeoaiiy (TH.A.Aieueaeaiaa?a e niaao., 1991; A.Kh.Kogan et al., 1993). Ianoaa?euei?noue i?ioean?a IIE o ia??iae aeaeoaeaiiy ae?oae ?c AA, OI, ?A niiioea? aei ooieoe?iiaeueiiai aeenaaeaino AIN. Ia?aaeon?i, aioo??oiueiee?oeii? aiceie (NIAe, E, NAeA) iaee eeoa oaiaeaioe?th aei c?inoaiiy i?e AA ? ?A (P>0.05), aea caeeoaeeny ?noioii ieae/eie ca
iieacieee o caei?iaeo. A i?e OI eaaaiue ai?no NIAe ? E iaa oaiaeaioe?th
aei iiaeaeueoiai cieaeaiiy (P>0.05). Oiaoi, aeoeai?noue
aioo??oiueiee?oeiieo cania?a aioeieneaeaioiiai caoenoo a ia??iae
aeaeoaeaiiy iaoe??io?a ?c AA, OI, ?A caeeoa?oueny ?noioii iecueeith
(P<0.05-0.001). Io?eiai? aeai? ocaiaeaeothoueny c aeniiaeaie aeine?aeiee?a, ui aeniaaeaiiy aeoeaiino? NIAe, E, NAeA o a?aeiia?aeue ia caiaeueiee i?ioean ? niaoeeo?/iith ?enith ci?i IIE (I.A.Ai?aethaiaa, 1993; E.A.Aiaaaeaeueieeia e niaao., 1993; J.M.Shoffner, 1995), a oaeiae caeaaeeoue a?ae oyaeeino? ee?i?/iiai ia?aa?ao (E.Ae.Neaei?iaa e niaao., 1994). Aecia/aiiy ??aiy SH-a?oi o aeai?e a?oi? oai?eo c’ynoaaei, ui o aeiaaeeo AA a?i cieaeo?oueny, o ii??aiyii? c aiaeia?/ieie aei e?eoaaiiy (P<0.01), a i?e OI oa ?A eieeaaiiy ia nooo?a? (P>0.05). Iaeiae, o an?o ianoaaeaieo
iieacieee SH-a?oi a?ae??ciyeeny a?ae o?c?ieia?/ieo (P<0.05-0.01), ui aeiaiaeeoue aeoeai?noue ia?ieneaeaoe?? e?i?ae?a o ia??iae aeaeoaeaiiy. Oe? aeai? aeathoue i?aenoaae noaa?aeaeoaaoe, ui aenieee ai?no SH-a?oi o ae?oae ?c O?I ? e?eoa???i aeoeaiino? caiaeueiiai i?ioeano. Aeeiai?ea OeI o ae?oae ?c aoii?/iith AA oa ?A i?iyaeyeany ?noioiei cieaeaiiyi eiai ai?noo (P<0.01), a i?e ?ioaeoe?eii-aea?a?/i?e AA oa OI aoea a?aenooiy. Aiaeii/an, o an?o oai?eo ? a?oie ai?no OeI o e?ia? aoa ?noioii aeuee ca iieacieee o caei?iaeo (P<0.01). Ne?ae iiaiaeeoeny c oeoia/aiiyi, ui aenieee ai?no OeI aeiaiaeeoue ?ioaeoe?eio i?e?iaeo caoai?thaaiiy (I.A.Ieiaethe e niaao., 1988; *.?.?aaeiia e niaao., 1992), ine?eueee a?i ? o ia??iae? ?aeiiaaeanoeaioe?? iaeneiaeueiei aoa o oai?eo ?c OI oa ?ioaeoe?eii-aea?a?/iith AA. I?ioa, OeI ? oe?iiei e?eoa???i aino?ioe caiaeueiiai i?ioeano, a oiio aeiaiaeeoue aeoeai?noue caiaeaiiy i?e OI i?aai?a aeeoaiiy, AA, ?A o ia??iae aeaeoaeaiiy. Ocaaaeueithth/e io?eiai? ?acoeueoaoe, ne?ae cacia/eoe, ui i?ioeane ?aeiiaaeanoeaioe?? ae?oae ?c O?I i?aai?a aeeoaiiy i?ney aacenii? oa?ai?? oa?aeoa?ecothoueny niia?eueiaieie oaiiaie noaa?e?caoe?? ooieoe?iioaaiiy ee?oeiieo iaia?ai. Oa ianoaaeia, ui oo?eio?oueny iaeiie/aiiy aenieeo eiioeaio?aoe?e i?iaeoeo?a IIE oa aeao?oeeo aicei?a ? e?i?? AIN, aeiaiaeeoue aeoeai?noue caiaeueiiai i?ioeano, oa?aeoa?eco? nooi?iue a?iien??. Aeine?aeaeaiiy iniiaieo iaoaaie?o?a niieo/ii? oeaieie o iaoe??io?a ? a?oie c’ynoaaei, ui oo?eiothoueny ?noioi? ii?ooaiiy eieaaaiiooai?aiiy. Cie?aia, ai?no ?iAo cacia? nooo?aiai cieaeaiiy eeoa i?e OI (ia 20.1%), a i?e ?A oa aoii?/i?e AA caeeoa?oueny iaci?iiei (P>0.05). Oiaoi, ia iiiaio
aeienee c? noaoe?iia?o i?ioeane ?oiaeiiaioeo?eiooai?aiiy aoee
i?enei?aieie o an?o oai?eo ? a?oie, a oiio na?ae/eee i?i o?eaaeo
aeaci?aai?caoe?th aeanoe/iiai ea?eano.

I?aeoe/ii aiaeia?/ia neooaoe?y niinoa??aaeany ii a?aeiioaiith aei
ienei?ie?io. A naia, i?e ?ioaeoe?eii-aea?a?/i?e AA oa OI eiai ai?no
ciaiooaaany ia ?noioii (P>0.05), a i?e ?A oa aoii?/i?e AA – caeeoaany
iiia?aaeiuei aenieei (P<0.01-0.001). Aenieee ??aaiue ienei?ie?io o ae?oae o ia??iae ?aeiiaaeanoeaioe?? ? na?ae/aiiyi iineeaiiai eiai neioaco e o/ano? o ?aia?aoeaieo ooieoe?yo niieo/ii? oeaieie ia caaa?oaeueiiio aoai? caiaeaiiy. Ia a?aenooi?noue ii?iae?caoe?? ai?noo ienei?ie?io aeacothoue ? ?io? aeine?aeieee (E.N.A?iae e niaao., 1989; A.A.Aa?aneiia e niaao., 1991), ine?eueee a oiiaao o?ii?/ii? a?iien?? a?aeaoaa?oueny iineeaiee neioac eieaaaio c ?icaeoeii o?a?icieo ci?i o a?iioieaaaiaaiio eiiieaen?. Aeeiai?ea NE o oai?eo ? a?oie iieyaaea o ?o ii?iae?caoe?? i?e OI oa ?A, a o aeiaaeeo AA – caeeoaeeny i?aeaeuaieie (P<0.05). Ioaea, io?eiai? a ? a?oi? aeai? aeiaiaeyoue, ui a ia??iae? aeaeoaeaiiy i?e AA, OI, ?A oo?eio?oueny yaeua aeeniaoaaie?cio niieo/ii? oeaieie. O oiae? caaaeueiiaeciaiiai e?eoaaiiy AA, OI, ?A (? a?oia) ia aoei aeinyaiooi nooo?aiai aieeao ia noai ee?oeiii? eaiee ?ioi?oaoo, a naia, e?euee?noue A-?OE oa AA-?OE i?e AA iaee oaiaeaioe?th aei iiaeaeueoiai cieaeaiiy (P>0.05), a i?e OI oa ?A – caeeoaeeny ia ??ai?, ui
a?aeiia?aeaa ii/aoeiaiio. Iaeiae, i?e an?o caoai?thaaiiyo aoa ?noioii
ieae/ei ca ii?io (P<0.01-0.001). Aiaeii/an, oo?eioaaany aeenaaeain ?ioii?aaoeyoi?ieo O-e?ioioeeo?a: ae?aaeaiee aeao?oeeo O*E, noaii?iaeueiee ai?no O?E. ??aaiue AAN-?OE oo?eioaaany a iaaeao o?c?ieia?/iiai, aeiyoie neeaee eeoa ae?oe c ?ioaeoe?eii-aea?a?/iith oi?iith AA, o eio?eo a?i ia?aaeuoaaa ii?io (P<0.05). Noai aoii?aeueiiai ?ioi?oaoo o oai?eo ? a?oie aecia/aea iicieia?/ia oi?ia O?I. Cie?aia, ai?no ?ioiiaeiaoe?i?a i?e aoii?/i?e AA oa?aeoa?ecoaaany eeoa oaiaeaioe??th aei cieaeaiiy Ig E, ca?eueoaiiy Ig G oa Ig A (P>0.05), a ioaea, caeeoathoueny ieae/eie a?ae ii?ie. Ii?yae ?c
oeei, oo?eio?oueny aenieee ??aaiue Ig M (2.4±0.1 a/e, P<0.001). O iaoe??io?a ?c ?ioaeoe?eii-aea?a?/iith oi?iith AA oo?eioaaany aeao?oeeo Ig G, Ig A ia oii? ii?iaeueiiai ai?noo Ig M oa a?ia??ioiiaeiaoe?iai?? A (P<0.05). A?aenooi?noue ii?iae?caoe?? iieaciee?a ?ioiiaeiaoe?i?a aeyaeaia o ae?oae ?c OI oa AA, ia ei?enoue ?noioii? iaaeinoaoiino? aioeo?e eeano Ig A oa Ig G (P<0.05). A?aeiii, ui a Ig M oa Ig G i?noyoueny aioeo?ea aei ee?oeiii? no?iee aaeoa??e-caoaeiee?a, ie??i oiai, a Ig G – aei oiene/ieo niieoe, ui aeae?ey? i?e?iaia ee?oeia, aai ye? ca?eueiythoueny i?e ?oeioaaii? ee?oeiieo iaia?ai. A oiio aeao?oeeo Ig G o ae?oae ?c caoooath/ei a?iioieaaaiaaei i?ioeanii ? iane?aeeii aeieoaaiiy oieneiaie neioaco aioeo?e. A on?o oai?eo ? a?oie a ia??iae aeaeoaeaiiy niinoa??aaeany i?aeaeuaia e?euee?noue Oe?E o e?ia? (P<0.01-0.05) oa oo?eioaaany aeao?oeeo eiiieaiaioo, ui aeiaiaeeei aeoeai?noue caiaeaiiy a oiiaao aoi?eiiiai ?ioiiaeao?oeeoo. Aeeiai?/ia aecia/aiiy INI o a?ieia?/ieo nenoaiao o oai?eo ?c AA, OI, ?A c’ynoaaei o 2/3 ianoaaeaieo aiaeioieneeic oo?eioaaany o noaae?? cai?ioiuei? aeaeiiiainaoe?? o ia??iae ?aeiiaaeanoeaioe??. I?ney o?aaeeoe?eiiai e?eoaaiiy o oai?eo ?c aoii?/iith AA oa OI oo?eioaaeeny aenieeie INI iaio ioe?a o ieaci? (P<0.05) oa a?eo?ioeeoao (P<0.01) i?e i?aeaeuai?e o?eueo?aoe?? INI ?c na/ath (P<0.05-0.001). Na?aae ae?oae ?c ?A aiaeiaaiia ?ioieneeaoe?y oo?eioaaeany ia iiia?aaeiueiio ??ai?, ui a?aeiia?aea? noaeiiiainiaai?e noaae??. O oai?eo ?c ?ioaeoe?eii-aea?a?/iith AA i?ney e?eoaaiiy aeinyaiooi ii?iae?caoe?? ai?noo INI a a?eo?ioeeoao oa ieaci?, ui noi?iaiaeaeoaaeiny i?aeaeuaiei ?o ??aiai o na/? (P<0.01). Oaeei /eiii, eiiieaenia oa?ai?y ?A, OI, AA ia caaacia/oaaea e?ea?aeaoe?? aiaeioienai??, ui ocaiaeaeo?oueny ?c ?ai?oa aeyaeaieie ii?ooaiiyie o nenoai? ia?ieneaeaoe?? e?i?ae?a, iai?i? niieo/ii? oeaieie oa ?ioa. Ca?aeii caaaeueieo iieiaeaiue, aeuacaaaeai? ci?ie iiaeooue aooe i?e/eiith ianooiiiai ?aoeeaeeao. A oe?eiio oea niiioeaei aei ai?iaaoe?? iiaeeo?eiaaieo noai e?eoaaiiy c iaoith noaa?e?caoe?? iieaciee?a aiiainoaco. Aecia/aiiy noaio ??aiiaaae oi?eaeueii? nenoaie IIE–AIN c’ynoaaei, ui canoinoaaiiy aioa?ini?aoe?? o oai?eo ?c ?A, AA, OI (?? a?oia) ia?aaeon?i ?noioii ciaiooaaei iaeiie/aiiy i?iaeoeo?a a?eueii?aaeeeaeueiiai ieeneaiiy (P<0.001). Iaeneiaeueii iecueeiai ai?noo IAeA o e?ia? aeinyaiooi i?e ?A, yeee noaiiaea 3.3±0.1 ieiieue/e (P<0.01) ? aoa ?noioii aeuei ca ii?io. Iaeiae, aeeoa?aioe?eiaaia aeiiiaiaiiy e?eoaaeueieo caoiae?a iaeiei ?c i?aia?ao?a cae?enithaaei a?eueo ae?aaeaiee aoaeo. ??aaiue IAeA ciaiooaaany o iine?aeiaiino? a?ae ?? aei V a?oie, a inoaii?e nyaaa o?c?ieia?/iiai ??aiy. Oaeei /eiii, i?ae aieeaii iiaeeo?eiaaieo noai e?eoaaiiy aeinyaiooi eiio?ieueiaaiee ??aaiue i?iaeoeo?a IIE. O?c?ieia?/iee ai?no IAeA (P>0.05) ae?aaiinoiaaiee eeoa o
ae?oae V a?oie, a a ?aooe ? /?oea oaiaeaioe?y aei ii?iae?caoe??.

Eiioeaio?aoe?y i?iaeoeo?a a?eueii?aaeeeaeueiiai ieeneaiiy ciaoiaeeeany o
??aiiaac? c ooieoe?iiaeueiith aeoeai?noth aioo??oiueiee?oeiieo aicei?a
AIN. Oae, aeiiiaiaiiy e?eoaaiiy aioa?ini?aoe??th (?? a?oia) ni?eyei
c?inoaiith aeoeaiino? E, NIAe, NAeA (P<0.05) o oai?eo ?c AA aoii?/iith oa ?A, iaeiae, iieacieee aoee ieae/? ii?ie (P<0.05-0.001). I?e OI oa ?ioaeoe?eii-aea?a?/i?e AA ??aaiue aioo??oiueiee?oeiieo oa?iaio?a ia caciaaaa nooo?aeo ci?i (P>0.05), caeeoath/enue ?noioii iecueeei. Oiaoi,
onoiaiiy eeoa aiaeioienai?? oeyoii aioa?ini?aoe?? ? iaaeinoaoi?i aeey
a?aeiiaeaiiy aeoeaiino? AIN. Aaeaea, oo?eio?oueny oeaieiia a?iien?y, ca
oiia yei? aeoeai?noue NIAe, E, NAeA caeeoa?oueny iecueeith.

C iiiaioo aeei?enoaiiy ?eaieneio aai ?aoi?ioaio, /e e?iinoaa?eo
ooieoe?iiaeuei? ?aca?ae aioo??oiueiee?oeiieo aicei?a o oe?e
iine?aeiaiino? aeeiai?/ii c?inoathoue (P<0.01), aea ia ii?iae?cothoueny. Iaeneiaeueii aeoeaiei ii a?aeiioaiith aei E, NAeA, NIAe aoei canoinoaaiiy e?iinoaa?eo i?e an?o oi?iao O?I i?aai?a aeeoaiiy. O ae?oae ??, ???, ?V a?oi aeoeaiaaiiio a ia??iae caaino?aiiy a?eueii?aaeeeaeueiiio ieeneaiith e?i?ae?a i?ioeae?yee caniae ?? e?i?? aioeieneaeaioiiai caoenoo. A naia, iacaeaaeii a?ae iicieia?/ii? oi?ie, oo?eioaaeeny i?aeaeuaieie SH-a?oie a e?ia? (P<0.05). Naia aiie cae?enithaaee iaeneiaeueiee aieea ia aeieoaaiiy i?ioean?a ia?ieneaeaoe?? ia noaae?? “aaeoaeaiiy” eaioethaa (TH.I.Aieueaeaiaa?a, 1991; E.A.Naa/aieiaa, 1996). Iaoii?noue, o oai?eo V a?oie ai?no SH-a?oi nyaioa cia/aiiy ii?ie, ine?eueee ??aaiue i?iaeoeo?a IIE a?aeiia?aeaa o?c?ieia?/iiio; a oei naiei, i?aeo?eioaaeany ??aiiaaaa nenoaie IIE–AIN. Ia oii? aaeineiiaeaieo noai e?eoaaiiy, o iaoe??io?a ??–V a?oi i?ioeane a?eueii?aaeeeaeueiiai ieeneaiiy iaaoee ea?iaaiiai oa?aeoa?o. Aeieacii /iai aoei cieaeaiiy ??aiy OeI, eio?ee, oi/ ? oo?eioaaany i?aeaeuaiei i?e aeei?enoaii? ni?aaio?a, aai c aeiiiaiaiiyi ?eaieneio /e ?aoi?ioaio (P<0.05–0.01). Iaeiae o iaoe??io?a V a?oie neioac OeI ii?iae?coaaany. Oaeei /eiii, ai?iaiaai? noaie e?eoaaiiy aieiae?thoue iaia?aiio?iiieie aeanoeainoyie, iaeiae cae?eniththoue ??ciee ii nee? iaia?aiinoaa?e?coth/ee aoaeo o oai?eo ?c AA, OI, ?A. Aeania aeiiiaiaiiy e?eoaaiiy aioa?ini?aoe??th (?? a?oia) cae?enith? ianiaoeeo?/iee aieea ia aeanoaa?e?ciaai? ee?oeii? iaia?aie. A naia, aiia caaacia/o? ni?aoe?th oiene/ieo i?iaeoeo?a e?i?aeiiai iioiaeaeaiiy (cieaeaiiy ??aiy IAeA), ui ciaioo? yaeua aiaeioienai??, a ca oeeo oiia c?inoa? aeoeai?noue aioo??oiueiee?oeiieo oa?iaio?a; cieea? iio?aaa o iineeaiiio neioac? OeI. Eo?n aioa?ini?aoe?? o ae?oae ?c AA, OI, ?A (?? a?oia) caaacia/oaaa ciyooy aeieo oiene/ieie ?a/iaeiaie ?aoeaioi??a, i?aeaeuaiiy no?eeino? oa niaoeeo?/iino? /ooeeaino? ee?oeiieo iaia?ai aei ciai?oi?o aieea?a. Aiaeii/an, c?inoa? aeoeai?noue a?oie ?aoeaioi??a aei ae?? iaaeeeaiaio?a, ui eyaei a iniiao eiiieaenii? oa?ai?? o oai?eo ???, IV, V a?oi. E?eoaaeueiee aoaeo a?ae canoinoaaiiy ?eaieneio (??? a?oia) iieyaa? o ca?eueoaii? aia?aaoe/iiai iioaioe?aeo ee?oeie, ine?eueee a?i ? iina?aaeieeii AOO. Oiaoi, ciaioaiiy i?iya?a oeaieiii? a?iien?? aaeueio? a?eueii?aaeeeaeuei? i?ioeane ieeneaiiy e?i?ae?a, ii?iae?co? ni?aa?aeiioaiiy i?ae aioo??oiuei- oa iicaee?oeiieie aioeieneaeaioieie oa?iaioaie. Noaa?e?coth/ee aieea ia i?ioeane ia?ieneaeaoe?? e?i?ae?a, a oiio – ? ia noai ee?oeiieo iaia?ai, cae?enithaaa ?aoi?ioai. Noaa?e?caoe?y IIE caaacia/o?oueny ciaioaiiyi a?iien?? caaaeyee iie?auaiith, ia?aaeon?i, i?e?ioee?eoeyoe?? a oeaieiao, a c oeei ca?eueoo?oueny iinooieaiiy a ee?oeio a?iaioeieneaeaio?a cciai?. Iaea?eueo aoaeoeaiei aoa e?iinoaa?e (V a?oia), eio?ee ii?aeiaa o nia? aeanoeaino? iaia?aiii?ioaeoi?a oa iaia?aiinoaa?e?caoi?a. Cie?aia, caaaeyee ai?noo a iueiio anaioe?aeueieo oinoie?i?ae?a, a?aeaoaa?oueny iiiaeaiiy e?i?aeiiai niaeo?o ee?oeiieo iaia?ai. Ie??i oiai, a?i aeieo? ia?ieneaeaoe?th e?i?ae?a ia ??ai? aaeoaeaiiy iaoieia?/iiai eaioethaa, a oiio ni?ey? ae??aithaaiith iica- oa aioo??oiueiee?oeiieo aicei?a AIN ia ei?enoue aeoeaaoe?? inoaii?o. E?iinoaa?e aieiae?? caeaoi?noth a?aeiiaethaaoe i?e?ioee?eoeyoe?th oa aa?’??io ooieoe?th a?iio?a oeyoii noeioeyoe?? i?ioean?a oeeoio?ii – ?-450-caeaaeii? iiiiieneaaiacii? nenoaie (A.Ae.Oea?aai?iaeoeaa, 1994). Io?eiai? aeai? aeathoue i?aenoaae aeeoa?aioe?eiaaii aeei?enoiaoaaoe ai?iaiaai? noaie, a caeaaeiino? a?ae aeeaeie aeano?oeoeaieo i?ioean?a o ee?oeiao oa ooieoe?iiaeueii? aeoeaiino? cania?a AIN. Aeinyaiaiiy ea?iaaiiai oa?aeoa?o ia?ieneaeaoe?? e?i?ae?a i?ae aieeaii aeeoa?aioe?eiaaieo iaoiae?a e?eoaaiiy noi?iaiaeaeoaaeiny iiceoeaiei aieeaii ia noai ?ioiieia?/ii? ??aiiaaae. Ia?oei “e?ieii oia?aae” aoei canoinoaaiiy aioa?ini?aoe??, yea caaacia/eea (?? a?oia) ciyooy aeieo oieneiaie iaoai?cio ae?iaeaiiy oa aeeoa?aioe?thaaiiy ?ioiieiiiaoaioieo ee?oei. Cie?aia, ia oii? oaiaeaioe?? aei ca?eueoaiiy A-?OE, ?noioii c?inoathoue AA-?OE oa iaiaaeo?oueny aeeeae o e?iaiiinia ?onei iaaeeoa?aioe?eiaaieo “0”-ee?oei. Aieea aioa?ini?aaio?a ianiaoeeo?/iee, a oiio ia a ciic? caaacia/eoe e?ioeaao ii?iae?caoe?th ee?oeiiiai ?ioi?oaoo i?e AA, ?A, OI. Iieacieee aoii?aeueiiai ?ioi?oaoo o oai?eo ?? a?oie caciaee ianooiieo ci?i. Ia?aaeon?i, aeei?enoaiiy aioa?ini?aaio?a caaacia/eei ii?iae?caoe?th ai?noo Ig E, aeoea?caoe?th neioaco aioeo?e Ig A o ae?oae ?c AA. Aioa?ini?aoe?y ni?eyea ciaioaiith ai?noo Ig M, iaeiae, ii?iae?coaaany a?i eeoa i?e aoii?/i?e AA (P<0.05). Eiiieaenia e?eoaaiiy oai?eo ?? a?oie noi?iaiaeaeoaaeiny oaiaeaioe??th aei ii?iae?caoe?? Ig G i?e O?I i?aai?a aeeoaiiy (P>0.05). Iie?auaiiy ni?aa?aeiioaiiy iniiaieo
?ioiiaeiaoe?i?a o oiae? aeaoieneeaoe?? ni?e/eieei ciaioaiiy Oe?E,
aeoeaaoe?th eiiieaiaioo (P<0.05), aea ?o cia/aiiy ia nyaioee iieaciee?a ye o caei?iaeo. ?acoeueoaoe, io?eiai? a ?? a?oi? iaoe??io?a, aeiaiaeyoue, ui ianiaoeeo?/iee aieea aioa?ini?aoe?? ia noai ?ioi?oaoo o ae?oae ?c ?A, AA, OI ia caaacia/o? eiai ii?iae?caoe??. Iaeiae, aeaoieneeaoe?y ? ia?oith oa ni?eyoeeaith oiiaith aei ?ioiiei?aeoe??, ine?eueee caaacia/o? iiceoeai? c?ooaiiy iaio eaiie ?ioi?oaoo. Aeiiiaiaiiy e?eoaaeueiiai eiiieaeno ?eaieneiii (??? a?oia) noi?iaiaeaeoaaeiny iiceoeaiei aieeaii ia noai ?ioi?oaoo. Anoaiiaeai? ?noioi? c?ooaiiy iieaciee?a ee?oeiii? eaiee ?ioi?oaoo a on?o iaoe??io?a ??? a?oie, o ii??aiyii? c aeaieie aei e?eoaaiiy oa o ? a?oi? (P<0.05). A naia, ca?eueooaaeany e?euee?noue A-?OE, AA-?OE, O*E, o?c?ieia?/iiio a?aeiia?aeaa ai?no AAN-?OE i?e AA, OI, ?A. Iaeiae, ii?iae?caoe?y ai?noo “I”-ee?oei oaeaeoa ianooiaea i?e aoii?/i?e, ai?ae i?e ?ioaeoe?eii-aea?a?/i?e AA. Iaea?eueo ae?aaeaia (P<0.05) iie?auaiiy noaio ee?oeiiiai ?ioi?oaoo anoaiiaeaii o ae?oae ?c OI, ui aea? i?aenoaae aaaaeaoe iaeiei ?c iniiaieo iaoai?ci?a ae?? ?eaieneio – ciaioaiiy ee?oeiii? ? oeaieiii? a?iien??, a oiio aeoea?co?oueny aeeoa?aioe?aoe?y O-e?ioioeeo?a. Caaaeath/e ia iiceoeaio aeeiai?eo nenoaie O-e?ioioeeo?a o ??? a?oi? oai?eo, i?e a?aenooiino? ?? ii?iae?caoe?? iiaeia aeei?enoiaoaaoe ?eaienei, ye ianiaoeeo?/iee ?ioiiiiaeoeyoi? i?e ?ioiiaeao?oeeo? ? nooiaiy. Aeyaeai? ?ioiiiiaeoethth/? aeanoeaino? oa?aeoa?ecoaaeeny iineeaiiyi neioaco O-ee?oei oa ooieoe?iiaeueii c??eeo (AA-?OE, O*E). Noai aoii?aeueiiai ?ioi?oaoo i?ae aieeaii ?eaieneio cacia? iiceoeaii? aeeiai?ee, o ii??aiyii? c aeaieie ia ii/aoeo e?eoaaiiy, iaeiae, ii?iae?coaaany eeoa ai?no Ig E. I?ney io?eiaiiai e?eoaaiiy o ae?oae ?c AA oa OI ai?no Ig G caeeoaany ?noioii iecueeei, a i?e ?A a?i c?inoaa (P<0.05), aea ii?ie ia nyaioa. Aiaeii/an, ??aaiue Ig M i?e an?o iicieia?/ieo oi?iao ciaiooaaany (P<0.05), aea o?c?ieia?/iiai ia nyaioa. O ae?oae ??? a?oie ia iiiaio aeienee c? noaoe?iia?o oo?eioaaany aeao?oeeo Ig A (P<0.05). Ie??i oiai, anoaiiaeaii, ui oaeaee?noue ae?i?iaoe?? Oe?E oa ii?iae?caoe?? aeoeaiino? eiiieaiaioo o oai?eo ??? a?oie iaaeinoaoi?, a oiio oaeiae i?aeo?eiothoue aeoeai?noue caiaeaiiy. Aiaeii/an, ai?iaiaaia noaia e?eoaaiiy, yea ni?yiiaaia ia iiaeieaiiy caiaeueiiai i?ioeano (IV a?oia) c ?aoi?ioaiii. Ca aeaieie aeine?aeaeaiue a aeai?e a?oi?, c’yniaaii, ui i?e O?I aeei?enoaiiy ?aoi?ioaio noi?iaiaeaeoaaeiny ca?eueoaiiyi caaaeueii? oa aeoeaii? o?aeoe?? O-e?ioioeeo?a, ii?iae?caoe??th ??aiy AAN-?OE. Iaeiae, oe? ia?aaoaeiae iaaeineiiae?, ine?eueee caaaeueiee ai?no O-e?ioioeeo?a ia nyaa? cia/aiue o caei?iaeo (P<0.05), a aeeoa?aioe?aoe?y ?ioiieiiiaoaioieo ee?oei a?aeaoaa?oueny ia ei?enoue eeoa O*E. Aoii?aeueiee ?ioi?oao o oai?eo IV a?oie oa?aeoa?ecoaaany yaeuai aeen?ioiiaeiaoe?iai??: oo?eioaaany aeao?oeeo Ig G (P<0.05), ??aaiue Ig M cieceany, aea aoa aeuei ca o?c?ieia?/iee (P<0.05), Ig E – ii?iae?coaaany. Neioac aioeo?e Ig A caeaaeaa o IV a?oi? a?ae a?eo aeine?aeaeoaaieo. Cie?aia, na?aae aeioe?eueiyo Ig A nyaioa i?e?iaeiueiai ??aiy eeoa i?e aoii?/i?e AA oa ?A. Iaoii?noue, o oeiey??a Ig A ii?iae?coaaany o an?o oai?eo, e??i iaoe??io?a ?c OI. Oea na?ae/eoue i?i oyaee?noue OI ye iaei??? c oi?i O?I i?aai?a aeeoaiiy, a oaeiae, ui o oeiey??a ii?iae?caoe?y caoenieo aioeo?e ianooia? oaeaeoa, ine?eueee ?ioiia nenoaia oe?eeiaeoi noi?iiaaia. Ia oii? i?iaaaeaii? oa?ai?? ?noioii cieceany ai?no Oe?E (P<0.05) oa aeeiai?/ii c?inoaa – eiiieaiaioo, iaeiae, iaeaeaa iieacieee ia nyaioee cia/aiue o caei?iaeo ae?oae. Ne?ae aeoiaoe, ui ianiaoeeo?/iee ?ioiiiiaeoethth/ee aoaeo ?aoi?ioaio iieyaa? o e?ea?aeaoe?? caiaeueiiai i?ioeano, a oea icia/a? iie?auaiiy i?e?ioee?eoeyoe?? oeaiei, i?eieiaiiy aeae?eaiiy iaae?aoi??a caiaeaiiy, iaeiie/aiiy i?ii?aeieo oa e?ioeaaeo i?iaeoeo?a niioai?aiiai iaoaaie?cio o?aaeaieo oeaiei. A oe?eiio, an? caaaeai? oaeoi?e a ciic? i?eai?/oaaoe i?e?iaeith ?ioiieia?/io a?aeiia?aeue. Ia ianiaoeeo?/i? ?ioiiiiaeoethth/? aeanoeaino? ?aoi?ioaio i?e AA caa?ioa oaaao eieaeoea aaoi??a (I.?.Eaneoey ? ni?aaao., 1994), ui anoaiiaeee ?i?oe?aoe?th i?ioean?a ?ioiiaaiaco i?ae aieeaii i?ioecaiaeueieo i?aia?ao?a. Ni?anoaaeyth/e aoaeoeai?noue ae?? cai?iiiiiaaieo eiiieaen?a e?eoaaiiy ia noai ?ioi?oaoo, aeyaeaii c?inoaiiy cia/eiino? o oae?e iine?aeiaiino?: aioa?ini?aoe?y ( aioa?ini?aoe?y + ?eaienei ( aioa?ini?aoe?y + ?aoi?ioai ( aioa?ini?aoe?y + e?iinoaa?e. Naia o iaoe??io?a V a?oie aeinyaiooi iaeneiaeueiiai iie?auaiiy, ui a?aeiia?aeaei cia/aiiyi o caei?iaeo ae?oae. Aeei?enoaiiy a eiiieaeni?e oa?ai?? e?iinoaa?eo o oai?eo ?c AA, OI, ?A caaacia/eei c?inoaiiy e?eueeino? A-?OE, AA-?OE, ye? a?aeiia?aeaee o?c?ieia?/i?e, ii?iae?caoe?th ai?noo AAN-?OE oa “I”-ee?oei. Ie??i e?euee?nieo ci?i ?ioii?aaoeyoi?ieo ee?oei, a?aeaoaaeeny ye?ni? ia?aaoaeiae: O?E/O*E ??aiiaaaa ii?iae?coaaeany. Noaa?e?caoe?y ee?oeiii? eaiee ?ioi?oaoo ni?eyea iie?auaiith noaio aoii?aeueii?. Ia?aaeon?i, aeaia e?eoaaiiy aeoea?coaaei neioac Ig G i?e OI, ?A, AA (V a?oia), cia/aiiy eio?iai ia ??cieeeny a?ae ii?ie (P>0.05).
I?eai?/aiiy ae?iaeaiiy aioeo?e eeano I aoei ?noioiei (P<0.01). I?e an?o iicieia?/ieo oi?iao, ?c iaeneioiii i?e OI, aeinyaiooi o?c?ieia?/iiai ??aiy Ig A c oaiaeaioe??th aei ia?aaeuaiiy ii?ie. I?e OI ??aaiue Ig A noaiiaea 1.9±0.1 a/e, ui aoa ?noioii aenieei (P<0.05). Aeoeaaoe?y i?iaeoeoe?? aioeo?e Ig A ?icoe?iaia ye aaeaioaoe?eii-caoenia ?aaeoe?y ?ioi?oaoo, ui iiaeiia caaacia/eoe o?eaaeo ?ai?n?th o?ii?/iiai a?iio?oo /e aoi?eiii? o?ii?/ii? iiaaiii??. Iacaaaeath/e ia oa, ui ai?no Ig E a ??, ???, IV a?oiao a?aeiia?aeaa ii?i?, ne?ae a?aei?oeoe, ui o ae?oae V a?oie a?i aoa iaeieae/ei. Aiaeii/an, i?iaaaeaia oa?ai?y i?ecaaea aei ciaioaiiy ai?noo Oe?E o e?ia? a 1.2–2.7 ?ac?a, o ii??aiyii? c aeo?aeieie aeaieie, a i?e ?ioaeoe?eii-aea?a?/i?e AA – aei iiaii? ii?iae?caoe??. Ia?aeaeueii c?inoaa neioac eiiieaiaioo (P<0.05–0.01), ui aeiaiaeea ciaioaiiy aeoeaiino? caiaeueiiai i?ioeano o ae?oae ?c ?A, OI, AA. Aeaeoaeaiiy ae?oae ?c O?I i?aai?a aeeoaiiy aeieea? ca oiiae cai?ioiueiai ?icaeoeo iaoieia?/ii? neiioiiaoeee iai?io niieo/iioeaieiieo aeaiaio?a. Iaeiae, ia oii? aeiiiaiaiiy aacenii? oa?ai?? aioa?ini?aoe??th (?? a?oia) ae?aaeaii? iiceoeaii? aeeiai?ee ca?a?no?iaaii ia aoei. I?e aecia/aii? ienei?ie?io a e?ia? anoaiiaeaii, ui eiai ai?no i?e AA, OI, ?A aoa oaeei, ye o ae?oae ? a?oie. Oiaoi ??aaiue ienei?ie?io o iaoe??io?a caeeoaany ?noioii i?aeaeuaiei (P<0.05–0.001). I?iaeoeoe?y niaoeeo?/ieo ?iAo ia oii? e?eoaaiiy ?noioii ciaiooaaeany i?e aoii?/i?e AA oa OI (P<0.01), a o ?aooe oai?eo eieeaaiiy aoee ia?noioieie. Eiiieaenia e?eoaaiiy iaoe??io?a ?? a?oie noi?iaiaeaeoaaeiny ii?iae?caoe??th ai?noo NE. O? c?ooaiiy, eio?? aeinyaioo? a oiae? e?eoaaiiy, iaoiiaeai? ciaioaiiyi aai ciyooyi caiaeueiiai i?ioeano a a?iioieaaaiaaiio eiiieaen?. O ??? a?oi? iaoe??io?a aeeiai?ea ai?noo ia?ea??a iai?io eieaaaiiaeo no?oeoo? aoea cia/ei?oith (P<0.05). Cie?aia, ??aaiue ienei?ie?io oa ?iAo caciaa iaeneiaeueiiai cieaeaiiy (P<0.01), o ii??aiyii? c iiia?aaei?ie aeaiia a?oiaie. Iaeiae, aiie caeeoaeeny ?noioii aeueie ca ii?io, ui aeiaiaeeei aeoeai?noue caiaeueiiai i?ioeano aea?a?/iiai (AA) oa ?ioaeoe?eiiai aaiaco (OI, ?A) o ia??iae aeaeoaeaiiy. Iai?eeeaae, na?aae oai?eo ??? a?oie iaeaeu? iieacieee ienei?ie?io a e?ia? aoee i?e aoii?/i?e AA (37.7±0.7 ieiieue/e, P<0.01), a ia i?e OI. Eia?/iei caeaaaany aeuee ??aaiue ienei?ie?io naia i?e OI, ine?eueee a?i oa?aeoa?eco? i?ioeane o?a?icieo oa neea?ioe/ieo ci?i o eaaaiyo. Iaeiae, o ae?oae ?c aoii?/iith AA o 35.4% aeiaaee?a niinoa??aaeeny aoii?/i? caoai?thaaiiy oe??e oa neeciaeo, a oiio aenieee ai?no ienei?ie?io aeiaiaeea, ui ?eaienei noeioeth? ?ioaineai?noue oa o?eaae?noue iaoaaie?cio eieaaaiiaeo a?ee?a o ?aaaia?oth/eo oeaieiao. Aeine?aeaeaiue aieeao ?eaieneio ia aeoeai?noue iai?io a niieo/i?e oeaiei? ia eeoa i?e O?I i?aai?a aeeoaiiy, aea e i?e ?io?e iaoieia?? aeeoy/iai a?eo ia ciaeaeaii. Iaeiae, ?acoeueoaoe aenia?eiaioaeueieo ?ia?o ia oaa?eiao (A.E.Aeee/, 1982) na?ae/aoue, ui ?eaienei aieeaa? ia a?aeiiai? i?ioeane o eaaaiyo, iiia?aaeaeoth/e iaaei??iee ?icaeoie aeaiaio?a niieo/ii? oeaieie. Oeo? ?iAo o oai?eo ia OI, AA, ?A ??? a?oie ?noioii cieaeoaaany (P<0.05), o ii??aiyii? c aeo?aeieie aeaieie. Aiaeii/an, i?ioeane ?oiaeiiaioeo?eiooai?aiiy oo?eioaaeeny ?ioaineai?oeie (P<0.001), ai?ae o caei?iaeo. Ca?nii, ui aeuei iieacieeai a?aeiia?aeaa oyae/ee ia?aa?a, inoaii? aeiaiaeeeiny iaeaeuei ??aiai ?iAo o iaoe??io?a ?c OI (29.0±2.1 oi.iae., P<0.05). Aecia/aiiy NE o oai?eo ?c ?A, AA, OI anoaiiaeei, ui ?o cia/aiiy nyaaee iieaciee?a ii?ie. sse ? ca aeaieie ?? a?oie, aeiaeueiao?oueny caeiiii??i?noue, ui aeaiee iaoiae ao?a/a? naith ae?aaiinoe/io oe?ii?noue i?e a?iioieaaaiaa?e iaoieia??. Io?eiai? aeai? aeaiiino?othoue aieea ?eaieneio ia aeenaaeain ?ioaineaiino? neioaco eieaaaiiaeo a?ee?a oa ?o eaoaaie?ci, iiia?aaeaeoth/e ca?eueoaiiy niieo/iioeaieiieo no?oeoo? oa a?aeiiaethth/e ni?aa?aeiioaiiy i?ae aeanoe/ieie aieieiaie e ?ioeie no?oeoo?ieie eiiiiiaioaie. Aeei?enoaiiy ?aoi?ioaio a eiiieaeni?e oa?ai?? AA, OI, ?A ni?eyei ii?iae?caoe?? ia?ea??a niieo/ii? oeaieie (IV a?oia). Cieaeaiiy ai?noo ?iAo oa ienei?ie?io aoee ?noioieie ii a?aeiioaiith aei aeo?aeieo aeaieo, aea ??cieeeny a?ae o?c?ieia?/ieo (P<0.05). ??aaiue NE i?e an?o iicieia?/ieo oi?iao ii?iae?coaaany. Noai iai?iieo i?ioean?a niieo/iioeaieiieo aeaiaio?a i?ae aieeaii e?iinoaa?eo (V a?oia) aeeiai?/ii iie?auoaaany, aea ia c??aiyany c ii?iith. I?ioa, naia o iaoe??io?a aeaii? a?oie ai?no ienei?ie?io ?noioii ia ??cieany a?ae o?c?ieia?/iiai (P>0.05), ui aeaiiino?o? a??aiiaaaeaiiy
i?ioean?a aia- oa eaoaaie?cio eieaaaio. E?iinoaa?e aaeueio? iaaei??iee
neioac niieo/iioeaieiieo no?oeoo?, a oiio iiaea caiia?aaoe oi?ioaaiith
/e iioe?aiith o?a?icieo ci?i o a?iioieaaaiaaiio eiiieaen?.

Ie??i oiai, i?ae aieeaii e?iinoaa?eo aaeueioaaany neioac ?iAo, ui
icia/a? noeoaiiy caiaeueiiai eiiiiiaioo, aeinyaiaiiy ea?iaaiiai noaio
ooai?aiiy e ?iaiethoe?? eieaaaiiaeo a?ee?a. Noaa?e?caoe?y
niieo/iioeaieiiiai iai?io i?e AA, OI, ?A caaacia/o?oueny eiai
iaia?aiii?ioaeoi?ieie aeanoeainoyie, ui niiioea? aei ciaioaiiy a?iien??
oeaiei oa nieiaiiy i?ioean?a eaoaaie?cio aeanoe/ieo aieieii.

Iiaeeo?eiaai? noaie e?eoaaiiy ni?e/eieee ?noioi? c?ooaiiy ia eeoa ??cieo
eaiie aiiainoaco, aea e iiaeieaiiy aeaeiiiainiaaii? noaae?? aiaeiaaiii?
?ioieneeaoe??. C iiiaioo aeiiiaiaiiy aacenii? oa?ai?? eo?nii
aioa?ini?aoe?? (?? a?oia) aoei aeinyaiooi ii?iae?caoe?? ai?noo INI iaio
ioe?a o ieaci?, ui ae?aaiinoiaaii ? a iaoe??io?a ianooiieo o?ueio
ee?i?/ieo a?oi. I?ioeane ni?aoe?? oienei?a iaia?aiaie a?eo?ioeeo?a ia
ao?aoeee naiai cia/aiiy i?e eiiieaenao e?eoaaiiy o ??? oa IV a?oiao.
Iaoii?noue, ??aaiue INI a a?eo?ioeeoao iaoe??io?a V a?oie aoa
o?c?ieia?/iei. I/aaeaeii, ui i?ae aieeaii iiooaeiiai
iaia?aiinoaa?e?caoi?a – e?iinoaa?eo – i?aeaeuo?oueny no?ee?noue
ee?oeiieo iaia?ai oa ii?iae?co?oueny i?iieeeea?noue. ??aaiue INI o e?ia?
o oai?eo iaa aiaeia?/io aeeiai?eo i?e an?o iicieia?/ieo oi?iao O?I
eaaaiue.

O oiae? aioa?ini?aoe?? c?inee ooieoe?iiaeuei? iiaeeeaino? i?aai?a, ui
aoiaeyoue aei nenoaie i?e?iaeiuei? aeaoieneeaoe??. Aeieacii /iai ?
i?aeaeuaiee ai?no INI (P<0.01-0.001) iaio ioe?a o na/?. Aeoeaia o?eueo?aoe?y oienei?a ?c na/ath o ii?aeiaii? c ii?iae?caoe??th ia?a?iciiae?eo INI i?ae no?oeoo?ieie eiiiiiaioaie e?ia? caaacia/eea eoioaaiiy aeaeiiiainiaaiiai oa?aeoa?o aiaeioienai??. Eaoaiianoe/ia niinoa?aaeaiiy ca ae?oueie anoaiiaeei, ui canoinoaaiiy aeeoa?aioe?eiaaieo noai e?eoaaiiy caaacia/eei o a?eueoino? ii?iae?caoe?th aeine?aeaeoaaieo iieaciee?a, ee?i?ei-eaai?aoi?ia ?ai?n?y oo?eioaaeany iaeaeiaoith o aeiaaeeo canoinoaaiiy IV oa V eiiieaeno oa?ai??. Ie??i oiai, o?eaae?noue ?ai?n?? caeaaeeoue a?ae aaeaeaaoiiai a?aooaaiiy c?ooaiue aiiainoaco i?e ie?aieo iicieia?/ieo oi?iao, ui iaoiiaeth? aea?? iaaeeeaiaioiciiai e?eoaaiiy. Aeniiaee Caaino?aiiy o?ii?/iiai oa ?aoeeaeeaoth/iai caiaeueiiai i?ioeano noi?iaiaeaeo?oueny ?noioiei aeenaaeainii iai?iieo i?ioean?a o niieo/i?e oeaiei?, ye? a eiiieaen? c ee?i?/ieie neiioiiaie aecia/athoue oyaee?noue ia?aa?ao. Iaeneiaeuei? c?ooaiiy ae?aaiinoiaai? i?e o?ii?/ieo caoai?thaaiiyo i?aai?a aeeoaiiy, ui aeiaiaeeoueny aenieei ??aiai ?oiaeiiiaeo aioeo?e o e?ia? (P<0.001) ? na?ae/eoue i?i i?aeaeuaiee neioac a?oaiaieieienoeo eieaaaiiaeo no?oeoo?. A?aeiiaeaiiy i?enooi?a a?iio?aeueii? anoie niiioea? aei iaeiie/aiiy aenieeo eiioeaio?aoe?e e?ioeaaeo i?iaeoeo?a ia?ieneaeaoe?? e?i?ae?a (P<0.001) a oiiaao ?noioiiai aeao?oeeoo aioo??oiueiee?oeiieo aicei?a aioeieneaeaioiiai caoenoo (P<0.01), ui a?aeiia?aea? noaio oieiai? iaia?aiiiao??. Aeoeaaoe?y caiaeueiiai i?ioeano o ae?oae ?c ?aoeeaeeaoth/ei a?iio?oii, o?ii?/ieie a?iio?oii ? aoi?eiiith iiaaiii??th noi?iaiaeaeo?oueny iaia?aiiiao??th, ine?eueee ?ioaineo?eaoe?y a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a a?aeaoaa?oueny ca oiia aeniaaeaiiy aioo??oiueiee?oeiieo aioeieneaeaio?a ? c?inoaiiy iicaee?oeiieo cania?a aioeieneaeaioiiai caoenoo. Iniaeea?noth aeine?aeaeoaaii? iaoieia?? ? oa, ui aiia ?icai?oa?oueny ia oii? aoi?eiiiai ee?oeiiiai ?ioiiaeao?oeeoo ? i?e ?aoeeaeeaoth/iio ia?aa?ao noi?iaiaeaeo?oueny aeen?ioiiaeiaoe?iai??th, a i?e o?ii?/iiio – aeoeaaoe??th neioaco Ig M, ae?aaeaiei aeao?oeeoii Ig A. Caaino?aiiy ?aoeeaeeaoth/iai a?iio?oo i?ecaiaeeoue aei i?eai?/aiiy i?noeaaeo oaeoi??a caoenoo neeciai?, ui aeiaiaeeoueny noaii?iaeueiei ai?noii Ig A oa a?ia?i?iaeoeoe??th a?eea o a?iioiaeueaaiey?iiio ciea?. Caaino?aiiy o?ii?/ii? a?iioieaaaiaai? iaoieia?? noi?iaiaeaeo?oueny aenieei ai?noii o a?iioiaeueaaiey?iiio ciea? Ig G ? M, a?eea (P<0.001) i?e ?noioiiio aeao?oeeo? Ig A, eio?? iaoiiaeththoue oyaee?noue caiaeueiiai i?ioeano. Canoinoaaiiy a eiiieaeni?e oa?ai?? ?aoeeaeeaoth/iai a?iio?oo, a?iio?aeueii? anoie, o?ii?/ii? iiaaiii?? ?eaieneio cae?enith? aioea?iienaioiee, aioeieneaeaioiee aieea, ui i?enei?th? ii?iae?caoe?th iaoaaie?/ieo i?ioean?a oa aeaeoaeaiiy (P<0.05). Aeei?enoaiiy a eiiieaeni?e oa?ai?? a?iio?aeueii? anoie, ?aoeeaeeaoth/iai a?iio?oo, o?ii?/ii? iaoieia?? eaaaiue e?iinoaa?eo caaacia/o? aeia?o iaia?aiii?ioaeoi?io ae?th, i?aeaeuo? aioeieneaeaioio aeoeai?noue, ni?ey? ii?iae?caoe?? i?ioean?a iai?io niieo/iioeaieiieo aeaiaio?a, oaeaeoiio iiaeieaiith caiaeueiiai eiiiiiaioo (P<0.01), ui a oe?eiio i?enei?th? oa?i?ie ?ai?n??. I?aeoe/i? ?aeiiaiaeaoe?? Aecia/aiiy iniiaieo iaoaaie?o?a niieo/ii? oeaieie (ienei?ie?i, ?oiaeiiia? aioeo?ea) a e?ia? oa i?ia?aeieo aioeieneaeaioieo oa?iaio?a aioo??oiuei- (noia?ieneaeaeeniooaca) oa iicaee?oeiii? (oea?oeiieaci?i) ni?yiiaaiino? aea? ciiao ?aeaioeo?eoaaoe aeeaeio aeoeaiino? caiaeueiiai i?ioeano oa ee?i?ei-eaai?aoi?ii? ?ai?n?? ?aoeeaeeaoth/iai a?iio?oo, o?ii?/ieo a?iio?oo oa aoi?eiii? iiaaiii??, a?iio?aeueii? anoie o ae?oae. I?e caaino?aii? a?iioieaaaiaaeo caoai?thaaiue, ui noi?iaiaeaeothoueny noaae??th cai?ioiuei? aeaeiiiainaoe?? aiaeioienai??, ?aeiiaiaeo?oueny 5-7-aeaiiee eo?n aioa?ini?aoe?? aoaeaoeaaeie ni?aaioaie c ?ic?aooieo 100-200 ia/ea iane o?ea aeeoeie ia aeiao. Ae?oyi ?c ?aoeeaeeaoth/ei a?iio?oii ? a?iio?aeueiith anoiith, ui ii?aeiothoueny ?c aoi?eiiei ?ioiiaeao?oeeoii (ee?oeiiee ?ioiiaeao?oeeo ? nooiaiy), aeen?ioiiaeiaoe?iai??th, aeanoaa?e?caoe??th ieenii-a?aeiiaieo i?ioean?a, e?eoaaiiy iaiao?aeii aeiiiaithaaoe ei?ioeei eo?nii aioa?ini?aoe?? ca caaaeaiith iaoiaeeeith oa ?eaieneiii per os ?c ?ic?aooieo 0.02 a/ea iane o?ea, i?ioyaii 2 oeaei?a. Oai?ei ia ?aoeeaeeaoth/ee a?iio?o, o eio?eo ae?aaiinoiaai? ?noioi? aeaci?aai?caoe?y iaoaaie?cio niieo/iioeaieiieo aeaiaio?a, aoi?eiiee ee?oeiiee ?ioiiaeao?oeeo ? nooiaiy, iaia?aiiiao?y, aeaeiiiainiaaia aiaeioienai?y, e?eoaaiiy ne?ae ei?eaoaaoe aioa?ini?aoe??th (ca caaaeaiith iaoiaeeeith) oa ?aoi?ioaiii ?c ?ic?aooieo 15-20 ia/ea iane o?ea ia aeiao, 2 oeaei?. Aeoeaaoe?y caiaeaiiy o ae?oae ?c a?iio?aeueiith anoiith, ?aoeeaeeaoth/ei a?iio?oii, o?ii?/ieie a?iio?oii ? aoi?eiiith iiaaiii??th a oiiaao ae?aaeaiiai eiia?iiaaiiai ?ioiiaeao?oeeoiiai noaio (ee?oeiia iaaeinoaoi?noue ??-??? nooiaiy), iaea?iaaieo i?ioean?a iineeaiiai eieaaaiiooai?aiiy, ia?ieneaeaoe?? ee?oeiieo e?i?ae?a, aeaeiiiainiaaii? aiaeioienai?? aeiaaa? aeei?enoaiiy a e?eoaaii? aioa?ini?aoe?? (iaoiaeeea iiia?aaeiy) oa aioo??oiueiaaiiiai e?aieeiiiai aaaaeaiiy e?iinoaa?eo c ?ic?aooieo 0.1-0.2 ie/ea iane o?ea ia aaaaeaiiy, 1 ?ac ia aeiao, 5-7 aei?a. Ia aoai? a?aeiiaiiai e?eoaaiiy ?aoeeaeeaoth/iai a?iio?oo oa a?iio?aeueii? anoie c iaoith ei?aeoe?? ii?ooaiiai aiiainoaco ia?aaaao ne?ae iaaeaaaoe ?eaieneio oa e?iinoaa?eo. Nienie iaoeiaeo i?aoeue, iioae?eiaaieo ca oaiith aeena?oaoe?? A?iio?aeueia anoia aeeoy/iai a?eo. – Oa?iii?eue, 1995. – 200 n. (Ni?aaaoi? ?.N.Ni?yi). Iaaeeei-nioe?aeuei? aniaeoe a?iio?aeueii? anoie o ae?oae // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1997. – ?9. – N.38-40. Ee?i?ei-a?iioieia?/ia ea?oeia caaino?aiiy o?ii?/ii? iiaaiii?? o ae?oae // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1997. – ?2. – N.29-30. I?aeoe/i? e?eoa??? ioe?iee aeoeaiino? caiaeueiiai i?ioeano i?e o?ii?/i?e ianiaoeeo?/i?e iiaaiii?? o ae?oae // Oe?a?inueeee ioeueiiiieia?/iee aeo?iae. – 1997. – ?1. – N.45-46. Aeoeai?noue aicei?a aioeieneaeaioiiai caoenoo o ae?oae ?c caaino?aiiyi o?ii?/ii? a?iioieaaaiaai? iaoieia?? // A?niee iaoeiaeo aeine?aeaeaiue. – 1997. – ?4-5. – N.85-86. No?oeoo?a caoai?thaaiino? ae?oae oai?iaaie i?aai?a aeeoaiiy ca inoaii? aeanyoe??//y ye ia?aaeoiiaa aeey i?aai?caoe?? iicanoaoe?iia?iiai e?eoaaiiy // AEo?iae AII Oe?a?ie. – 1997. – O.3, ?2. – N.267-273. (Ni?aaaoi?e: Ni?yi ?.N., Iicaeaanueeee A.O., Iaae?eueei A.I., Ai?iioeiaa O.I., Aaa?iaoeue O.N., E?uaiei I.I., Iaaeeoei A.A.). Iniaaiiinoe eeeie/aneiai oa/aiey ?aoeeaeeae?othuaai a?iioeoa o aeaoae e aiciiaeiua iooe eo ?aaaeeeoaoeee // Iaaeaeoia?iaeiue iaaeeoeeineee aeo?iae. – 1997. – ?4. – N.88-89. Aeieia?/ii iaoiiaeaia niiaoe/ia iaoieia?y o ae?oae // I?iaeaie aeieia?? oa iaaeeoeeie. – 1998. – ?3-4. – N.14-15. (Ni?aaaoi? Eiaiaea A.O.). Noai neeciai? iaieiiee aa?oi?o a?aeae?e?a o?aaiiai eaiaeo o ae?oae i?e o?ii?/i?e a?iioieaaaiaa?e iaoieia?? // A?niee A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. – 1998. – ?1. – N.152-153. (Ni?aaaoi? Eiaiaea A.O.). Ia?a?iciiae?e na?aaei?o iieaeoe o a?ieia?/ieo na?aaeiaeuao o ae?oae ?c ?aoeeaeeaoth/ei a?iio?oii // Oe?a?inueeee iaoeiai-iaaee/iee iieiae?aeiee aeo?iae. – 1998. – ?1. – N.94-95. Aioea?iienaioia caeaoi?noue ?eaieneio a eiiieaeni?e oa?ai?? a?iio?aeueii? anoie o ae?oae // Oa?iaoeaaoe/iee aeo?iae. – 1998. – ?1. – N.70-73. Aeeiai?ea iaoaaie?/ieo c?ooaiue niieo/ii? oeaieie o ae?oae ?c a?iio?aeueiith anoiith // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1998. – ?6. – N.26-28. ?ioiiaeiaoe?iii?ioa?iiaee i?io?eue a?iioiaeueaaiey?iiai eaaaaeo o ae?oae ?c caaino?aiiyi o?ii?/ii? ianiaoeeo?/ii? a?iioieaaaiaai? iaoieia?? // A?niee iaoeiaeo aeine?aeaeaiue. – 1998. – ?3-4. – N.110-112. Aoaeoeai?noue aeei?enoaiiy ?aoi?ioaio a e?eoaaii? o?ii?/ieo a?iioieaaaiaaeo caoai?thaaiue o ae?oae // Oa?iaoeaaoe/iee aeo?iae. – 1998. – ?3. – N.43-46. Noai aioeieneaeaioii? oa ?ioiii? nenoai o ae?oae ?c ?aoeeaeeaoth/ei a?iio?oii ? a?iio?aeueiith anoiith // AEo?iae AII Oe?a?ie. – 1998. – O.4, ?3. – N.545-551. Ai?no ienei?ie?io a e?ia? – ia?aee?i?/iee e?eoa??e aeaci?aai?caoe?? niieo/ii? oeaieie o ae?oae ?c a?iio?aeueiith anoiith // Oe?a?inueeee iaoeiai-iaaee/iee iieiae?aeiee aeo?iae. – 1998. – ?2-3. – N.68-69 Noai aoii?aeueiiai oa i?noeaaiai ?ioi?oaoo o ae?oae ?c o?ii?/iith a?iioieaaaiaaith iaoieia??th // Oe?a?inueeee ioeueiiiieia?/iee aeo?iae. – 1999. – ?1. – N.46-47. Nooue neiae?iio aiaeiaaiii? ?ioieneeaoe?? o ae?oae i?e caaino?aii? a?iio?aeueii? anoie // A?niee iaoeiaeo aeine?aeaeaiue. – 1999. – ?2. – N.52-54. (Ni?aaaoi? ?iaaeuenueeee ?.I.). Ee?i?/i? ia?ea?e aea?a?? a ae?oae o no/ani?e aeieia?/i?e neooaoe?? // Aeieia?/ia o?c?ieia?y. – 1998. – ?1. – N.7-9. I?eioeeie a?aeiiaiiai e?eoaaiiy ae?oae ?c o?ii?/iith a?iioieaaaiaaith iaoieia??th // Iaaee/ia ?aaa?e?oaoe?y, eo?i?oieia?y ? o?c?ioa?ai?y (Aeiaeaoie). – 1998. – ?1. – N.150-151. ?iciianthaeaeai?noue aea?a?/ieo caoai?thaaiue na?aae ae?oae Oa?iii?euenueei? iaeano? oa iniaeeaino? ?o ia?aa?ao // Iaoeia? caienee Oa?iii?euenueeiai aea?aeaaiiai iaaeaaia?/iiai oi?aa?neoaoo ?i. Aieiaeeie?a Aiaothea. – Na??y: A?ieia?y. – 1999. – ?2 (5).– N.73-76. Noai iane/aiiy e?noie eaeueoe??i o ae?oae ?c a?iio?aeueiith anoiith // I?iaeaie inoaieia??. – 1999. – O.2, ?1. – N.95. (Ni?aaaoi?e: Ni?yi ?.N., ?iaaeuenueeee ?.I., Aieyinueea E.A., Einianueea O.I., Eaaaiaoeue N.N.) Iniaeeaino? aiaeia?iio?oo a ae?oae ?c a?iio?aeueiith anoiith oa ?aoeeaeeaoth/ei a?iio?oii // Aoeiaeinueeee iaaee/iee a?niee. – 1999. – ?3. – N.12-16. Ianiaoeeo?/i? ?ioiiiiaeoethth/? aeanoeaino? e?iinoaa?eo a e?eoaaii? ae?oae ?c a?iio?aeueiith anoiith // Oa?iaoeaaoe/iee aeo?iae. – 1999. – ?4. – N.95-97. O?aaeaiiy aa?oiueiai a?aeae?eo o?aaiiai eaiaeo o ae?oae c o?ii?/iith iiaaiii??th oa ?aoeeaeeaoth/ei a?iio?oii // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1999. – ?4. – N.110. (Ni?aaaoi?e: Ni?yi ?.N., Oe?aeeeei ?.I., Eooeoe A.I., Ii?ic ?.I., Oeyia I.A.). Aniaeou aaiaoiaeeea?iie iaoieiaee i?e a?iioeaeueiie anoia // Iao/. i?aeo. eiio. “Iiaia a aeeaaiinoeea e ea/aiee caaieaaaiee i?aaiia ieuaaa?aiey”. – Oa?ueeia, 1994. – N.118. Iaa?oiooaaiiy o?eaaeiai canoinoaaiiy iaia?aiinoaa?e?coth/i? oa?ai?? o ?aaa?e?oaoe?? ae?oae ?c ?aoeeaeeaoth/ei a?iio?oii // Iaoa?. Ieaioio iaoe.-iaae. oiaa?enoaa aeeoy/eo e?ea??a “?aaa?e?oaoe?y a iaae?ao???”. – Ee?a–Oa?iii?eue, 1995. – N.8. Aeeaeia o?aaeaiue a?ieia?/ieo iaia?ai o ae?oae, ui oai??thoue o?ii?/ieie caoai?thaaiiyie a?iioieaaaiaai? nenoaie // Iaoa?. ? I?aeia?. eiia?ano c ?ioaa?aoeaii? aio?iiieia??. – Oa?iii?eue, 1995. – N.221. (Ni?aaaoi? Eiaiaea A.O.). Cia/aiiy ooieoe?iiaeueiiai noaio oeoieiai-eeoeiaiai o?aeoo i?e a?iio?aeuei?e anoi? a aeeoy/iio a?oe? // Ia?oee Oe?a?inueeee eiia?an aano?iaioa?ieia?a. – Aei?i?iiao?ianuee, 1995. – N.139. Iniaeeaino? oi?ioaaiiy oa ia?aa?ao aiaeiaaiii? ?ioieneeaoe?? o ae?oae c a?iio?aeueiith anoiith // I?aeia?. eiia?an iieiaeeo a/aieo oe?a?ioe?a. – ?aaii-O?aie?anuee, 1995. – N.53-54. Aioeieneaeaioiee caoeno a?ieia?/ieo iaia?ai o ae?oae c ?aoeeaeeaoth/ei a?iio?oii // Iaoa?. I?aeia?. eiio. “Aeooaeuei? ieoaiiy ii?oieia??”. – Oa?iii?eue, 1996. – N.60-61. Iaoiaaiaoe/aneea iniaaiiinoe ea/aiey a?iioeaeueiie anoiu o aeaoae ia oiia eeioaoeei-aeiiieanoe/aneie aiiiaeee eiinoeoooeee // Na. iao/. o?. “Oeiiiaaaeey”. – Caii?iaeuea. – 1996. – N.65-66. (Ni?aaaoi? Eiaiaea A.O.). Ia?aa?a aea?a?/ieo caoai?thaaiue i?aai?a aeeoaiiy o ae?oae a no/anieo aeieia?/ieo oiiaao // Iaoa?. eiio. “Aeieia?y oa noai caei?ia’y ianaeaiiy a no/anieo oiiaao”. – Oaeai?iae, 1996. – N.43-44. Aeoeai?noue i?ioean?a ?oiaeiiaioeo?eiooai?aiiy i?e a?iio?aeuei?e anoi? o ae?oae // ? Iaoe?iiaeueiee eiia?an Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe??. – Aeoooa, 1998. – N.102. (Ni?aaaoi? Eiaiaea A.O.). Ee?i?ei-a?iioineii?/i? aniaeoe o?ii?/ii? iiaaiii?? o ae?oae // Iaoa?. ?ani. iaoe. i?aeo. eiio. “Aeooaeuei? ieoaiiy iaaeeoeeie”. – Oiaeueieoeueeee, 1998. – N.170-172. Aaiaaeeaa I.A. Ee?i?ei-iaoiaaiaoe/i? aniaeoe o?ii?/ieo ? ?aoeeaeeaoth/eo ianiaoeeo?/ieo a?iioieaaaiaaeo caoai?thaaiue o aeeoy/iio a?oe? oa ?o e?eoaaiiy. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.10 – iaae?ao??y. – ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, Ee?a, 1999. I?aaenoaaeai? ?acoeueoaoe ee?i?ei-eaai?aoi?ieo oa ?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy ae?oae ?c caaino?aiiyi ?aoeeaeeaoth/iai a?iio?oo, o?ii?/iiai a?iio?oo oa aoi?eiii? o?ii?/ii? iiaaiii??, a?iio?aeueii? anoie. Aeine?aeaeaia aeoeai?noue ?oiaeiiaioeo?eiooai?aiiy i?e aeai?e iaoieia??, ui ianooue ?ioi?iaoe?th i?i aeeaeio caiaeaiiy oa caeaaeaoue a?ae o?eaaeino? iniiaiiai caoai?thaaiiy, ia’?io o?aaeaiiy oa no?oeoo?e noiooiuei? iaoieia??. Aeaci?aai?caoe?y niieo/ii? oeaieie oo?eio?oueny ? a ia??iae? ee?i?/ii? ?ai?n??. Aeaoaeueii i?aaenoaaeai? i?e/eii? ca’ycee i?ae aeenaaeainii aioeieenethth/eo cania?a o?ueio e?i?e aioeieneaeaioii? nenoaie e aeoeai?noth a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a o ia??iae caaino?aiiy o?ii?/ieo ? ?aoeeaeeaoth/eo a?iioieaaaiaaeo caoai?thaaiue, a oaeiae aecia/aiee oaeoi? aioeieneaeaioiiai noaio. Icia/aia no?oeoo?a ci?i ?ioiia?io?i?/iiai i?io?eth a?iioiaeueaaiey?iiai cieao oa aecia/ai? oaiaeaioe?? ?o ?icaeoeo a caeaaeiino? a?ae nooiaiy aiaeia?iio?oo. Aeine?aeaeoaai? iieacieee aiiainoaco a ii?aeiaii? c aecia/aiiyi iieaeoe na?aaeiuei? iane o o?ueio a?inenoaiao aeaee iiaeeea?noue ae?aaiinooaaoe noaae?th cai?ioiuei? aeaeiiiainaoe?? aiaeioienai??. Iaa?oioiaai? oa aaeineiiaeai? iaoiaee ae?aaiinoeee aeoeaiino? caiaeueiiai i?ioeano i?e a?iioieaaaiaa?e iaoieia??. Iaoiaaiaoe/ii iaa?oioiaaii, ai?iaiaaii oa i?iaaaeaii ioe?ieo aoaeoeaiino? aeei?enoaiiy a eiiieaeniiio e?eoaaii? e?iinoaa?eo aeey ei?aeoe?? c?ooaiue aiiainoaco. Eeth/ia? neiaa: ae?oe, ?aoeeaeeaoth/ee a?iio?o, a?iio?aeueia anoia, o?ii?/iee a?iio?o, o?ii?/ia aoi?eiia iiaaiii?y, ?ioiia nenoaia, ?oiaeiiia? aioeo?ea, a?iioiaeueaaiey?iee ciea, aiaeioienai?y, e?eoaaeuei? caoiaee. Aaiaaeuaa I.A. Eeeieei-iaoiaaiaoe/aneea aniaeou o?iie/aneeo e ?aoeeaeeae?othueo ianiaoeeoe/aneeo a?iioieaai/iuo caaieaaaiee a aeaoneii aic?anoa e eo ea/aiea. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.10 – iaaeeao?ey. – Einoeooo iaaeeao?ee, aeooa?noaa e aeiaeieiaee AII Oe?aeiu, Eeaa, 1999. I?aaenoaaeaiu ?acoeueoaou eeeieei-eaai?aoi?iuo e eino?oiaioaeueiuo iaoiaeia enneaaeiaaiee aeaoae n iaino?aieai ?aoeeaeeae?othuaai a?iioeoa, o?iie/aneiai a?iioeoa e aoi?e/iie o?iie/aneie iiaaiiiee, a?iioeaeueiie anoiu. Auyaeai eiiieaen eciaiaiee ni noi?iiu nenoaiu aiiainoaca, eioi?ua ii?aaeaeytho aeoaeio ainiaeeoaeueiiai i?ioeanna e oyaeanoue enneaaeoaiie iaoieiaee. ?aaioa niaea?aeeo eiiieaen enneaaeiaaiee, eioi?ua auiieiaiu 556 aieueiui aeaoyi (330 – no?aaeaee a?iioeaeueiie anoiie, 134 – ?aoeeaeeae?othuei a?iioeoii, 92 – o?iie/aneie iaoieiaeae: a?iioeoii e aoi?e/iie iiaaiiieae) a aic?anoa io 2 aei 14 eao e 80 caei?iaui oaeiai aea aic?anoa. Eniieueciaaeenue eeeie/aneea, eiioiieiae/aneea, aeioeie/aneea, a?iioineiie/aneea, ?aioaaiieiae/aneea, aaeoa?eieiae/aneea iaoiaeu. Enneaaeiaaia aeoeaiinoue i?ioeannia ?oiaeiiaioeoaeiia?aciaaiey, eioi?ua aeaaeatho eioi?iaoeeae i aeoaeia ainiaeaiey e caaenyo io aeeeoaeueiinoe iniiaiiai caaieaaaiey, iauaia iia?aaeaeaiey e ninoaaa niioonoaothuae iaoieiaee. Eco/aiu iniaaiiinoe iaoaaieecia niaaeeieoaeueiie oeaie ai a?aiy iaino?aiey ?aoeeaeeae?othuaai a?iioeoa, eioi?ua caeeth/athony a eioaineaiii ia?aciaaiee ?oiaeiiiauo aioeoae, iiauoaiiii iaiaia ienei?ieeia. Aeiiieiaiu i?aaenoaaeaiey ia caeiiiia?iinoyo iaiaia niaaeeieoaeueiie oeaie o aeaoae n a?iioeaeueiie anoiie, o?iie/aneei a?iioeoii, eioi?ua naeaeaoaeuenoaotho ia oneeaiiii aia- e eaoaaieecia a?oaiaieieienouo aaeeia. Ia?ooaiiue iaoaaieeci niaaeeieoaeueiioeaiiuo yeaiaioia i?e o?iie/aneie e ?aoeeaeeae?othuae a?iioieaai/iie iaoieiaee o aeaoae i?ineaaeeaaaony e a ia?eiaea eeeie/aneie ?aiennee, /oi iiaeao noaoue i?e/eiie iineaaeothueo iaino?aiee. Iaino?aiea a?iioieaai/iie iaoieiaee nii?iaiaeaeaaony aoi?e/iui eeaoi/iui eiioiiaeaoeoeeoiui ninoiyieai e aeeneiioiiaeiaoeeiaieae. A oi aea a?aiy iaino?aieth o?iie/aneie iaoieiaee eaaeeo oa?aeoa?iu aeoeaaoeey neioaca Ig M (P<0.01), au?aaeaiiue aeaoeoeeo Ig A (P<0.01) a e?iae, /oi ii?aaeaeyao iniaaiiinoe eeeie/aneiai oa/aiey. Aeaoaeueii i?aaenoaaeaiu i?e/eiiua nayce iaaeaeo aeenaaeainii aioeieeneeoaeueiuo n?aaenoa o?ao o?iaiae aioeieneaeaioiie nenoaiu e aeoeaiinoueth naiaiaeii?aaeeeaeueiiai ieeneaiey eeieaeia a ia?eiae iaino?aiey o?iie/aneeo e ?aoeeaeeae?othueo a?iioieaai/iuo caaieaaaiee. Aia?aua ii?aaeaeai oaeoi? aioeieneaeaioiiai ninoiyiey i?e enneaaeoaiie iaoieiaee. Iainiiaaii, /oi iaino?aiea a?iioeaeueiie anoiu niioaaonoaoao ninoiyieth oieiaie iaia?aiiiaoee, a ?aoeeaeeae?othuaai, o?iie/aneiai a?iioeoia e aoi?e/iie o?iie/aneie iiaaiiiee – iaia?aiiiaoee. Ii?aaeaeaia no?oeoo?a eciaiaiee eiioiiaeioeie/aneiai i?ioeey a?iioiaeueaaiey?iiai niuaa e eo caaeneiinoue io noaiaie yiaeia?iioeoa. ?aoeeaeeae?othuee a?iioeo nii?iaiaeaeaaony nieaeaieai ianoiuo oaeoi?ia caueou neecenoie, /oi iaoneaaeeaaao noaii?iaeueiia niaea?aeaiea Ig A e aeinoiaa?ii aunieee o?iaaiue aaeea (P<0.01) a a?iioiaeueaaiey?iii niuaa. Iaino?aiea o?iie/aneie iaoieiaee eaaeeo annioeee?oaony n iiauoaiiui niaea?aeaieai a a?iioiaeueaaiey?iii niuaa Ig G e M, aaeea (P<0.001) ia oiia au?aaeaiiiai aeaoeoeeoa Ig A. Enneaaeoaiua iieacaoaee aiiainoaca a niaieoiiinoe n ii?aaeaeaieai iieaeoe n?aaeiae iannu a o?ao aeieiae/aneeo n?aaeao (y?eo?ioeeou, ieacia, ii/a) aeaee aiciiaeiinoue aeeaaiinoe?iaaoue i?e iaino?aiee o?iie/aneie eee ?aoeeaeeae?othuae iaoieiaee eaaeeo noaaeeth ia?aoiie aeaeiiiainaoeee yiaeioienaiee. Iainiiaaiu e niaa?oainoaiaaiu iaoiaeu aeeaaiinoeee aeoeaiinoe ainiaeeoaeueiiai i?ioeanna i?e a?iioieaai/iie iaoieiaee. Iaoiaaiaoe/anee iainiiaaia, ai?iae?iaaia e i?iaaaeaia ioeaiea yooaeoeaiinoe noaiu ea/aiey n eniieueciaaieai eeiinoaaeea n oeaeueth ei??aeoeee auyaeaiiuo ia?ooaiee aiiainoaca i?e o?iie/aneie e ?aoeeaeeae?othuae iaoieiaee i?aaiia aeuoaiey o aeaoae. Eeth/aaua neiaa: aeaoe, ?aoeeaeeae?othuee a?iioeo, a?iioeaeueiay anoia, o?iie/aneee a?iioeo, o?iie/aneay aoi?e/iay iiaaiiiey, eiioiiay nenoaia, ?oiaeiiiaua aioeoaea, a?iioiaeueaaiey?iue niua, yiaeioienaiey, ea/aaiua ia?ii?eyoey. Banadyga N.V. Clinico-pathogenetic aspects of chronic and relapsing non-specific bronchopulmonary diseases in childhood and their treatment. – Manuscript. The scientific work for a Doctor’s Degree in speciality 14.01.10 – Pediatrics. Institute of Pediatrics, Obstetrics and Gynecology of the Ukrainian Academy of Medical Sciences, Kyiv, 1999. The findings of clinico-laboratory and instrumental investigation methods of children with exacerbated relapsing bronchitis, bronchial astma, chronic bronchitis and secondary pneumonia were presented. The activity of the rumalon antibodies formation process was studied, it giving information about the inflammation depth and depending upon the basic disease duration, the lesion value and the associated pathology structure, respectively. Disorganization of the connective tissue was maintained in the period of clinical remission too. There were presented in detalis the causal relationships between the disbalance of the three lines means in antioxidant system and free radical lipids peroxidation activity in the exacerbation period of chronic and relapsing bronchopulmonary diseases and the antioxidant state factor was determaned as well. There was defined the immunobiochemical changes structure in bronchoalveolar lavage and the tendency to these changes development depending on endobronchitis state. The homeostasis indices indices studied in combination with defining medium-sized molecules in three biosystems enabled to diagnose the endotoxemia relapsing decompensation stage. The diagnostic methods of the inflammatory processactivity in bronchopulmonary pathology was substantiated and improved. The estimation of lipostabil efficfcy use in a complex treatment for homeostasis lesions corrections was pathogenetically grounded and approved. Key words: children, relapsing bronchtis, bronchial astma, chronic bronchitis, chronic secondary pneumonia, immune system, rumalon antibodies, bronchoalveolar lavage, endotoxemia, treating measures. IA?AE?E OIIAIEO NEI?I*AIUe AIC – aioeieneaeaioiee caoeno AA – a?iio?aeueia anoia AAC – a?iioiaeueaaiey?iee ciea E – eaoaeaca IAeA – iaeiiiaee aeeaeueaeaa?ae INI – iieaeoee na?aaeiuei? iane ?A – ?aoeeaeeaoth/ee a?iio?o ?iAo – ?oiaeiiia? aioeo?ea NAeA – noeoeeiaoaeaa?ae?iaaiaca NIAe – noia?ieneaeaeeniooaca O?I – o?ii?/ia ? ?aoeeaeeaoth/a iaoieia?y OI – o?ii?/ia iaoieia?y: a?iio?o oa aoi?eiia iiaaiii?y OeI – oea?oeiieaci?i

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