I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO

IIEIEIA?? ? ?AAe?IEIA??

OAeE 616.611-002-053.2-073.75

OAIAN?*OE-AAAEE?AA Iaoae?y Aieiaeeie??aia

?IOAA?AEUeIA OA?AEOA?ENOEEA NOAIO IA*?IEE, I?AeOEOIEIAI? CAEICE, OEOIEO
I?E AEIIA?OEIIAO?EO? O Ae?OAE (EE?I?EI —

AOI?AAe?IIOEE?AeI? AeINE?AeAEAIIss)

14.01.23 — i?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia ia eaoaae?? iaaee/ii? ?aae?ieia?? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. I.I. Aiaiiieueoey oa eaoaae?? iaaee/ii?
?aae?ieia?? Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.
Ai?ueeiai.

Iaoeia? eiinoeueoaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eaca? A. I. — caa. eaoaae?ith
iaaee/ii? ?aae?ieia?? Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i. I.I.
Aiaiiieueoey,

aeieoi? iaaee/ieo iaoe, i?ioani? Aaaaeana?iaa ?. A. — caa.
a?aeae?eaiiyi aeeoy/i? iao?ieia?? ?inoeoooo o?ieia?? oa iao?ieia?? AII
Oe?a?ie.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Oeoe?ia A. A. — aieiaiee iaoeiaee
ni?a?ia?oiee, eiinoeueoaio a?aeae?eo ?aae?aoe?eii? iieieia?? oa yaea?ii?
iaaeeoeeie Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo iieieia?? oa
?aae?ieia?? IIC Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani? Oeeaaieia A. O. — i?ioani? eaoaae?e
a?enueeiai? oieneeieia??, ?aae?ieia?? ? iaaee/iiai caoenoo
A?enueeiai-iaaee/iiai ?inoeoooo OAIA

aeieoi? iaaee/ieo iaoe, Aeaieniaa I. O. — caa. a?aeae?eaiiyi
aano?iaioa?ieia?? ?inoeoooo iaae?ao???, aeooa?noaa ? a?iaeieia?? AII
Oe?a?ie.

I?ia?aeia onoaiiaa — Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?
ina?oe ?i. I. E. Ooieea (eaoaae?a iaaee/ii? ?aae?ieia??) IIC
Oe?a?ie.

Caoeno a?aeaoaeaoueny “17” 12 1998 ?. i ___ aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.619.01 i?e Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? iieieia?? oa ?aae?ieia?? IIC Oe?a?ie
(252022 i. Ee?a, aoe. Eiiiiiniaa 33/43).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo.

Aaoi?aoa?ao ?ic?neaiee “___” ________ 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe Aeeeai ?. I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie

Aeiia?oeiiao?eo (AI) caeia? aeii?ioth/a i?noea na?aae ia?aioeiaoicieo
caoai?thaaiue ie?ie, ye? iae/ano?oa ni?e/eiythoue ?iaae?ae?caoe?th oa
nia?oi?noue a iieiaeiio i?aoeacaeaoiiio a?oe? (I.N. Eaiaoiaa, 1989; E.A.
Ei?iaeia ? ni?aaao., 1990; I.ss. ?aoia? ? ni?aaao.,1992; B.Curtis,
1988).

A inoaii? ?iee i?e AI niinoa??aathoueny iaaaoeai? aoaeoe c aieo ?ioeo
i?aai?a oa nenoai, iaoiiaeai? ai?aaiaoe/ieie oaeoi?aie (i?iieneia?
a?aeoiaee, iane?aeee aaa??? ia *AAN, n?euenueeiainiiaea?nuee?
aeiaeaoee), cieaeaiiyi ?ioii?aaeoeaiino? i?aai?cio, ci?iith
a??oeaioiino? i?e?ii?aai?ci?a, ni?eyth/eo ?icaeoeo AI oiui (E.A.
Aaaaeana?iaa ? ni?aaao., 1991; A.E. Iaoiiaa, 1991; I.O. Aic?aiia, 1995;
A.A. Eaaiia ? ni?aaao.,1996; M. Wyszinska ? ni?aaao., 1984; A.Y.
Barakat, 1990). Ia aeeeth/aii, ui iaoieia?/iee i?ioean a ie?eao
iia’ycaiee ?c noaiii nenoaie o?aaeaiiy,nooo?aa ?ieue yei? a iie?i?aaiieo
aca?iiae?yo oa a?aeiia?aeieo ?aaeoe?yo i?aai?cio a?aeiia (E.A.Iu?ea,
I.ss. Iaeueiai, 1982; A.E. Ooeooei, 1995; A.Alvestrand, J. Bergston,
1984; C. Am?el ? ni?aaao., 1991; T, Seno ? ni?aaaao, 1995; D.
Haussinger, 1996).

Caaaeath/e ia oa, ui ?icaeoie iie?i?aaiii? neiioiiaoeee ye
a?aeiia?aeii? ?aaeoe?? i?aai?cio ia AI a ?yae? aeiaaee?a cia/ii iaoyaeo?
ia?aa?a oa i?ecaiaeeoue aei i?ia?anoaaiiy i?ioeano a ie?eao, aea/aiiy
ooieoe?iiaeueieo, no?oeoo?ieo, aaiiaeeiai?/ieo ci?i a i?aaiao o?aaeaiiy
yaey?oueny aeooaeueiei oa iaiao?aeiei aeey ?ic?iaee e?eoaaeueii —
i?io?eaeoe/ieo caoiae?a i?e AI.

Oaeiae iaaeinoaoiuei ae??oai? aeaye? aaaeeea? ieoaiiy, iia’ycai? c
e?eoaaiiyi iao?ioe/ii? (IO) oa ci?oaii? (CO) oi?i AI (I.A. Iooei, 1987;
A.A. Eaiaiaaaaa ? ni?aaao., 1991; A.A. Eaaiia, 1993; I.I. Eieaniee,
1995). Aaaaoi??/iee aeina?ae canoinoaaiiy aetheiei?oeei?ae?a (AE) oa
oeeoinoaoee?a (OeN) na?ae/eoue i?i oa, ui ia o?eueee naii caoai?thaaiiy
aieeaa? ia ?icaeoie iie?i?aaiii? neiioiiaoeee, aea ? aeei?enoaiiy
iaoiaaiaoe/ii? oa?ai?? aeeeeea? iaaaaeai? iia?/i? aoaeoe oa oneeaaeiaiiy
(I.A. Iaaeaioeaa, A.I. Oei/aiei, 1988; E.A. Ia?eiaa ? ni?aaao., 1994;
A.A. Iaiayi, I.Ae. Naaaieiaa, 1997; P. Tarshish ? ni?aaao., 1992).

?icaeoie o aeayeeo oai?eo aaiaoeoo, noa?i?aeiiai ae?aaaoo, ae?acee
oeoieo, aoeeae?cio iaiaaeo? canoinoaaiiy AE ? OeN oa i?ecaiaeeoue, a
naith /a?ao, aei i?ia?anoaaiiy ? o?ii?caoe?? AI. A ca’yceo c oei, ui
ia?oei aa?’??ii aeey oeeo i?aia?ao?a i?e ia?i?aeueiiio canoinoaaii?
yaeythoueny i?aaie o?aaeaiiy, aea/aiiy nooiaiy iioeiaeaeaiiy inoaii?o
iio?aao? niaoe?aeueieo aeine?aeaeaiue, ni?yiiaaieo ia ae?aaiinoeeo
noaee?i?/ii? aano?iaioa?ieia?/ii? neiioiiaoeee.

A e?oa?aoo?? ?niothoue eeoa ie?ai? iia?aeiieaiiy i?i ee?i?ei —
eaai?aoi?i?, iaoiii?oieia?/i?, aiaeineii?/i? aeine?aeaeaiiy i?aai?a
o?aaeaiiy i?e AI (A.A. Iaeiaaoeeay, 1979; A.A. Ai?aieue ? ni?aaao.,
1982; A.N. ?unn ? ni?aaao., 1989; I.N. Iiue/, O.A. Aeiiae, 1990). I?ioa
aiie o?ea/ano?, ia a?aeaeaathoue aca?iica’ycie i?ae noaiii nenoaie
o?aaeaiiy oa iaoieia?/iei i?ioeanii a ie?eao, ia a?aoiaothoue aieeao
iaoiaaiaoe/ii? oa?ai??.

A iaai?e i??? oea iiaeia iiynieoe iaaeinoaoi?i aeei?enoaiiyi no/anieo
aeniei?ioi?iaoeaieo, iao?aaiaoe/ieo ?aae?iioee?aeieo oa oeueo?acaoeiaeo
iaoiae?a ae?aaiinoeee, ye? aeicaieythoue iaea?aeaoe ia’?eoeaia oyaeaiiy
i?i ooieoe?iiaeuei? ci?ie i?aai?a o?aaeaiiy. A iaae?ao???, iniaeeai a
oiiaao aeieia?? Oe?a?ie, e?aua aeei?enoiaoaaoe iaoiaee, ui aeicaieythoue
oieeaoe ii?ii?iaiiy oai?eo — ?aae?i?ioiieia?/iee aiae?c (??A),
oeueo?acaoeiaa neaioaaiiy, aeiiiea?iaoia?ao?y (E.I. Aaa?thoiaa ?
ni?aaao., 1991; E.A. Aeai?yeianeee, 1994; A.O. Eeeiaiei, 1995; H.B.
Patriquin ? ni?aaao.,1990; R. Leppek ? ni?aaao., 1995). A oie aea /an ie
aaaaea?ii ca aeioe?eueia aeeth/aoe a eiiieaen aeine?aeaeaiue ?
aaiianoeeioea?ao?th — iacai?iiee iaoiae ooieoe?iiaeueii? ae?aaiinoeee,
yeee noai?th? i?i?iaeueia i?iiaiaaa iaaaioaaeaiiy ia aeeoy/ee i?aai?ci
(O.I. Neaa/aiei ? ni?aaao., 1991; I.E. Ieeeiaiei ? ni?aaao., 1992; K.
Kostic ? ni?aaao., 1995).

Caaaeaia aeua iaa?oioiao? iaiao?aei?noue eiiieaeniiai
aoi?aae?iioee?aeiiai aeine?aeaeaiiy i?aai?a o?aaeaiiy aeey nai?/anii?
ae?aaiinoeee, i?iaiicoaaiiy ooieoe?iiaeueieo ?iceaae?a oa iioei?caoe??
oaeoeee e?eoaaiiy AI o ae?oae.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie

?iaioa aeeiiaia ca?aeii c ieaiii IAe? Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i. I.I. Aiaiiieueoey oa ?inoeoooo o?ieia?? oa iao?ieia??
AII Oe?a?ie ? yaey?oueny o?aaiaioii eiiieaenii? oaie “Iaoeiai
iaa?oiooaaoe nenoaio i?io?eaeoe/ieo oa e?eoaaeueieo caoiae?a aeey ae?oae
c caoai?thaaiiyi ie?ie, i?iaeeaath/eo a cii? iineeaiiai ?aae?aoe?eiiai
eiio?ieth, ia i?aenoaa? iiaeo iaoiaee/ieo i?aeoiae?a uiaei ae?aaiinoeee,
?aaa?e?oaoe?? oa canoinoaaiiy aioa?ini?aaio?a a eiiieaen? iaoiaaiaoe/ii?
oa?ai??”. Aea?ae. ?a?no?aoe?y oaie ? 292/3.

Iaoa ?iaioe

Iioei?caoe?y ae?aaiinoeee ?aii?o no?oeoo?ii-ooieoe?iiaeueieo ii?ooaiue
i?aai?a o?aaeaiiy a aeeiai?oe? iaoiaaiaoe/ii? oa?ai?? aeiia?oeiiao?eoo o
ae?oae oeyoii ?ic?iaee aeai?eoio eiiieaeniiai i?iiaiaaiai aeine?aeaeaiiy
aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy, noai?aiiy
e?eoaaeueii-i?io?eaeoe/ieo caoiae?a, caiia?aath/eo ?icaeoeo o?ii?/ii?
ie?eiai? iaaeinoaoiino?.

Caaaeaiiy aeine?aeaeaiiy

1. Aea/eoe ooieoe?iiaeueiee noai ia/?iee, i?aeoeoieiai? caeice, oeoieo
i?e iao?ioe/i?e oi?i? AI o ae?oae ca aeiiiiiaith ??A, oeueo?acaoeiaiai
aeine?aeaeaiiy (OCAe), noeeioea?ao?? a caeaaeiino? a?ae ia?aa?ao oa
oi?ie AI, aoaio iaoiaaiaoe/ii? oa?ai??, noao?, a?eo oai?eo, iayaiino?
noiooi?o caoai?thaaiue i?aai?a o?aaeaiiy.

2. Aea/eoe ooieoe?iiaeueiee noai iae?ioaaaeueii? nenoaie ia/?iee ?
aioo?eoiueiia/?ieiai? aaiiaeeiai?ee ca aeiiiiiaith aaiaoinoeeioea?ao??
(ANA) c 99i On-eiei?aeii ? aeiiiea?ioeoiiao??? (AeOI) ia aoaiao
e?eoaaiiy AI.

3. Ioa?aeoa?ecoaaoe ooieoe?iiaeueiee noai aaiaoia?e?a?ii? nenoaie ca
aeaieie aeeiai?/ii? aaiaoia?e?noeeioea?ao?? (AANA) c 99mOn — IACEAeA ?
?aae?i?ioiieia?/iiai aecia/aiiy oie?eae?oeeio (OA) a ne?iaaooe? e?ia? o
ae?oae c AI.

4. Anoaiiaeoe iniaeeaino? no?oeoo?ii — ooieoe?iiaeueiiai noaio
aecie?eiii? oa aiaeie?eiii? /anoei i?aeoeoieiai? caeice i?e AI ca
aeaieie ??A o?eineio, aetheaaiio, N — iaioeaeo, ?inoe?io a ne?iaaooe?
e?ia? oa aoia?ao??.

5. Aecia/eoe ?ieue aano?i?ioanoeiaeueieo ai?iii?a — aano?eio,
nae?aoeio, aaciaeoeaiiai ?ioanoeiaeueiiai iie?iaioeaeo (A?I), oeoieiaiai
?ia?a?oi?iiai iaioeaeo (O?I), ?a/iaeie ? a ooieoe?iiaeueieo ci?iao
o?aaiiai eaiaeo i?e AI.

6. ?ic?iaeoe ee?i?ei — aoi?aae?iioee?aei? e?eoa??? ii?ooaiue ooieoe??
i?aai?a o?aaeaiiy i?e AI o ae?oae aiane?aeie canoinoaaiiy
aetheiei?oeei?ae?a oa oeeoinoaoee?a.

7. Aecia/eoe caeaaei?noue i?ae noaiii i?aai?a o?aaeaiiy ca aeaieie
aoi?aae?iioee?aeieo aeine?aeaeaiue oa ?icaeoeii iia?/ieo ae?e oa
oneeaaeiaiue iaoiaaiaoe/ii? oa?ai??, oi?ioaaiiyi ai?iiii/ooeeaino? oa
aoaeoeai?noth e?eoaaiiy AI.

8. ?ic?iaeoe oa iaa?oiooaaoe canoinoaaiiy ae?aaiinoe/iiai aeai?eoio
aoi?aae?iioee?aeieo aeine?aeaeaiue a i?ioean? iaoiaaiaoe/ii? oa?ai?? AI
o ae?oae aeey iioei?caoe??? aeine?aeaeaiiy ? i?aeaeuaiiy aoaeoeaiino?
e?eoaaiiy.

Iaoeiaa iiaecia ?iaioe

Aeena?oaoe?eia ?iaioa ae??oo? aeooaeueio aeey i?iiaiaai? ae?aaiinoeee
oa aeeoy/i? iao?ieia?? i?iaeaio — i?aeaeuaiiy aoaeoeaiino? ae?aaiinoeee
oa e?eoaaiiy caoai?thaaiue ie?ie o ae?oae oa i?io?eaeoeee oneeaaeiaiue
iaoiaaiaoe/ii? oa?ai?? iao?ioe/ii? oi?ie AI.

Aia?oa ca aeiiiiiaith eiiieaeno aoi?aae?iioee?aeieo aeine?aeaeaiue
aecia/ai? iniaeeaino? ooieoe?iiaeueiiai noaio ia/?iee, i?aeoeoieiai?
caeice, oeoieo o ae?oae, oai?eo ia AI a aeeiai?oe? iaoiaaiaoe/ii?
oa?ai??. Aia?oa ia i?aenoaa? aaaaoioaeoi?iiai ei?aeyoe?eiiai aiae?co
aeyaeaii aca?iica’ycie ooieoe?iiaeueieo ii?ooaiue i?aai?a o?aaeaiiy ?c
ia?aa?aii AI, aoaiii aetheiei?oeei?aeii? oa oeeoinoaoe/ii? oa?ai??,
anoaiiaeai? caeiiii??iino? aeuacaaaeaieo ci?i a caeaaeiino? a?ae
aa??aioo ai?iiii/ooeeaino? oa aoaeoo e?eoaaiiy. Aecia/aia ?ieue ie?aieo
aoi?aae?iioee?aeieo iieaciee?a ye ?aii?o ia?ea??a iiaeeeaeo oneeaaeiaiue
oa iia?/ii? ae?? i?aia?ao?a iaoiaaiaoe/ii? oa?ai??. Aia?oa aeyaeai?
iniaeeaino? aano?i?ioanoeiaeueiiai noaoono ia i?aenoaa? aeaieo
?aae?i?ioiieia?/iiai aecia/aiiy ?aaoeyoi?ieo iaioeae?a ne?iaaoee e?ia?
i?e iao?ioe/i?e oi?i? AI o ae?oae a aeeiai?oe? e?eoaaiiy.

?ic?iaeaii ae?aaiinoe/iee aeai?eoi aeey nai?/aniiai aeyaeaiiy
aano?iaioa?ieia?/ieo ii?ooaiue i?e AI o ae?oae oa ?aoe?iiaeuei?e ?o
ei?aeoe?? ia aoai? canoinoaaiiy iaeneiaeueieo aeic aetheiei?oeei?ae?a oa
oeeoinoaoee?a. Cai?iiiiiaaiee aeai?eoi yaey? niaith oaoiieia?/ia
??oaiiy, ?aae?caoe?y eio?iai aiineoue iiceoeaiee aianie a
iaoeiai-oaoi?/iee i?ia?an a aaeoc? i?iiaiaai? ae?aaiinoeee oa aeeoy/i?
iao?ieia??, ine?eueee ni?ey? i?aeaeuaiith aoaeoeaiino? e?eoaaiiy oa
ia?aoeiaeaeo? o?ii?caoe?? i?ioeano a ie?eao o ae?oae oai?eo ia
iao?ioe/io oi?io AI.

I?aeoe/ia oe?ii?noue ?iaioe

Aeieacaia iiaeeea?noue oni?oiiai aeei?enoaiiy ?aae?iioee?aeieo oa
oeueo?acaoeiaeo iaoiae?a aeey aea/aiiy noaio ia/?iee, i?aeoeoieiai?
caeice, oeoieo i?e iao?ioe/i?e oi?i? AI o ae?oae oa ia’?eoeaii? ioe?iee
?o ooieoe?iiaeueiiai noaio i?ae aieeaii iaoiaaiaoe/ii? oa?ai??.
Iaa?oioiaaii aoaiia aeine?aeaeaiiy oai?eo ca aeiiiiiaith ?ic?iaeaiiai
ae?aaiinoe/iiai eiiieaeno a ia??iae canoinoaaiiy iaeneiaeueieo aeic
aetheiei?oeei?ae?a ? oeeoinoaoee?a oa iaiao?aei?noue o?eaaeiai
aeeniaina?iiai niinoa?aaeaiiy ca oai?eie i?ae /an ee?i?ei — eaai?aoi?ii?
?ai?n??.

Anoaiiaeai? caeiiii??iino? ?icaeoeo ooieoe?iiaeueieo oa no?oeoo?ieo
ci?i aaiaoia?e?a?ii? nenoaie, i?aeoeoieiai? caeice ? oeoieo a i?ioean?
iaoiaaiaoe/ii? oa?ai?? AI o ae?oae aeicaieeee iaa?oiooaaoe oa aecia/eoe
iniiai? iai?yiee aaeaeaaoii? ei?aeoe?? ciaeaeaieo ii?ooaiue.

Eiiieaenia ?aae?i?ioiieia?/ia aeine?aeaeaiiy ai?iii?a i?aeoeoieiai?
caeice, o?eineio aeicaiey? nai?/anii aecia/eoe ?icaeoie
aeeniaie?aaoecio, iaie?aaoe/ii? iaaeinoaoiino?, ?aaeoeaiiai iaie?aaoeoo,
ioe?ieoe ?aca?ai? iiaeeeaino? i?aeoeoieiai? caeice i?e aeieeiaii?
yo?iaaiiiai neiae?iio Eooeiaa.

A?iiaano?eiai?y, ciaeaeaia ia oii? e?eoaaiiy AI, yaey?oueny
i?iaiinoe/ii iani?eyoeeaith iciaeith ?icaeoeo iaaeeeaiaioiciiai
o?aaeaiiy oeoieo o ae?oae, ui aeicaiey? iaa?oiooaaoe iaiao?aei?noue eiai
i?io?eaeoeee.

Ioe?iea ooieoe?iiaeueiiai ? iaoaaie?/iiai noaio ia/?iee, i?aeoeoieiai?
caeice, oa?aeoa? ia/?ieiai? aaiiaeeiai?ee aeicaiey? aecia/eoe nooi?iue
iaaee/ii? ?aaa?e?oaoe?? i?e iao?ioe/iiio neiae?ii? AI o ae?oae oa
niaoeeo?eo aeeniaina?iiai niinoa?aaeaiiy.

Iniiai? iieiaeaiiy aei caoenoo

1. ?aae?i?ioiieia?/iee aiae?c, aeiiiea?ioeoiiao??y, noeeioea?ao?y
ia/?iee c 99iOn- eiei?aeii oa 99iOn- IACEAeA, aoia?ao?y iiaeooue aooe
aeei?enoai? ye aenieiaoaeoeai? iaoiaee ioe?iee iaoaaie?/ieo,
ai?iiiaeueieo, noaeeiieo, ooieoe?iiaeueieo ? no?oeoo?ieo ci?i i?aai?a
o?aaeaiiy a aeeiai?oe? e?eoaaiiy AI o ae?oae.

2. Nooi?iue ae?aaeaiino? ii?ooaiue i?aai?a o?aaeaiiy i?e AI o ae?oae
caeaaeeoue a?ae ia?aa?ao, oi?ie, noaae?? caoai?thaaiiy, aeei?enoiaoaaieo
e?eoaaeueieo i?aia?ao?a, a?eo, noao? iaoe??io?a, iayaiino? noiooi?o
aano?iaioa?ieia?/ieo caoai?thaaiue.

3. ?acoeueoaoe ioe?iee noaio ia/?iee, i?aeoeoieiai? caeice, oeoieo
iathoue a??ia?aei? a?aei?ie o oai?eo c ??ciei aoaeoii e?eoaaiiy,
aa??aioii ai?iiii/ooeeaino?, i?e ?icaeoeo oneeaaeiaiue oa iia?/ieo yaeu
iaoiaaiaoe/ii? oa?ai??.

4. Aeyaeai? ci?ie iae?ioaaaeueii? ? aaiaoia?e?a?ii? nenoai, ii?ooaiiy
aioo??oiueiia/?ieiai? aaiiaeeiai?ee, aiaeie?eiii? ? aecie?eiii?
iaie?aaoe/ieo ooieoe?e, iniaeeaino? aano?i?ioanoeiaeueiiai noaoono o
ae?oae c iao?ioe/iith oi?iith AI iio?aaothoue nai?/anii? aaeaeaaoii?
ei?aeoe?? aeey oni?oiiai i?iaaaeaiiy iaoiaaiaoe/ii? oa?ai??.

5. Ae?aaiinoe/iee aeai?eoi aeicaiey? aecia/eoe oaeoeeo
aeeoa?aioe?eiaaiiai eiiieaeniiai ianoaaeaiiy oai?eo ia AI i?ae /an
e?eoaaiiy.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? o i?aeoe/io ae?yeuei?noue
iaeanii? aeeoy/i? ee?i?/ii? e?ea?i? i. Aeiiaoeueea, iao?ieia?/ieo
a?aeae?eaiiue i?nueeeo aeeoy/eo e?ea?aiue i. Ee?aa (? 1, ? 6 ? ? 7), i.
Neioa?iiiey, i. Aei?i?iiao?ianueea, aeeth/ai? aei iaa/aeueieo i?ia?ai
eaoaae? iaaee/ii? ?aae?ieia?? oa aeeoy/eo oai?ia Aeiiaoeueeiai
iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a

Aaoi?ii iniaenoi cai?iiiiiaaii eiiieaen aoi?aae?iioee?aeieo
aeine?aeaeaiue aeey ioe?iee noaio i?aai?a o?aaeaiiy i?e AI o ae?oae.
Aaoi? iniaenoi i?iaiaeea a?aea?? oai?eo ca a?oiaie ca?aeii oe?eyi ?
caaaeaiiyi aeine?aeaeaiiy, i?eeiaa o/anoue a iaoiaeao, ee?i?/ieo
?icai?ao oa iaoeiaeo eiioa?aioe?yo a?aeae?eaiiy aeeoy/i? iao?ieia?? ?OI,
aea ae??ooaaeenue ae?aaiinoe/i? ieoaiiy uiaei noaae?? oai?iae, ?ai?n??,
i?ecia/aeenue eaai?aoi?i? oa a?io?i?/i? aeine?aeaeaiiy, ?ic?iaeyeanue
oaeoeea oa?ai??, ioe?ithaaeanue ?? aoaeoeai?noue. Iniaenoi i?iaaaeaia
?ic?iaea ?noi??e oai?iae oa noai?aia aaca aeaieo. Aaoi?ii iniaenoi
?ic?iaeaia i?ia?aia aiae?co ?acoeueoao?a niinoa?aaeaiue, cai?iiiiiaaii
eiiieaen oaeoi??a aeey i?iaaaeaiiy ei?aeyoe?eiiai aiae?co, aeeiiaii
aiae?c io?eiaieo ?acoeueoao?a, noai?aii ae?aaiinoe/iee aeai?eoi,
c?iaeai? aeaiaee, i?aeoe/i? ?aeiiaiaeaoe??.

?aae?iioee?aei? aeine?aeaeaiiy (noeeioea?ao?y ? ?aae?i?ioiieia?/ia
oanooaaiiy) aeeiiai? aaoi?ii iniaenoi, niiia?ao?/i? aeine?aeaeaiiy
i?iaaaeai? ni?eueii c e?ea?ai oeueo?acaoeiai? ae?aaiinoeee.

Ai?iaaoe?y ?iaioe

Ai?iaaoe?y i?iaaaeaia ia iaoeia?e eiioa?aioe?? eaoaae?e iaaee/ii?
?aae?ieia?? Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i. I.I.
Aiaiiieueoey oa a?aeae?eaiiy aeeoy/i? iao?ieia?? ?inoeoooo o?ieia?? oa
iao?ieia?? AII Oe?a?ie.

Iniiai? iieiaeaiiy aeena?oaoe?? aeeeaaeai? ia Oe?a?inueeeo iaoeiai —
i?aeoe/ieo eiioa?aioe?yo c i?iiaiaai? ae?aaiinoeee (Aeiiaoeuee, 1993,
Aeoooa, 1996, Oa?e?a, 1997), 30 -iio Eiia?an? ?a?iiaenueeiai oiaa?enoaa
aeeoy/eo ?aae?ieia?a (Aaeeeia?eoai?y, Eiiaeii, 1993), Oe?a?inueeiio
Eiia?an? ?aae?ieia?a (Ee?a,1995), I?aeia?iaeieo neiiic?oiao “Iia?
iai?yiee a aaiaoieia??” (Naieo-Iaoa?ao?a, 1996, Euea?a, 1997), XIY
i?aeia?iaei?e eiioa?aioe?? “AEia/i? eeneioe ? aaiaoia?e?a?i?
caoai?thaaiiy“ (I?ia//eia, O?aeao?a, 1996), 10 -iio Ac?aonueei —
Oeoiieaainueeiio Eiia?an? c aano?iaioa?ieia?? (ssiii?y, Eieiaaia, 1996).

No?oeoo?a oa ianya aeena?oaoe??

Aeena?oaoe?y aeeeaaeaia ia 344 noi??ieao iaoeiiieno, neeaaea?oueny ?c
anooio, 6 aeaa, iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiiy, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae e?oa?aoo?e (564
aeaea?aea), ?c ieo 279 — ?iicaiieo aaoi??a. ?iaioa i?noeoue 124
iaethiea, 27 oaaeeoeue.

Ioae?eaoe??

?acoeueoaoe aeena?oaoe?? aeeeaaeai? o 43 ioae?eaoe?yo (na?aae ieo 15
noaoae) o aeo?iaeao, ca??ieeao iaoeiaeo i?aoeue, iaoa??aeao ? oacao
Oe?a?inueeeo oa i?aeia?iaeieo eiioa?aioe?e oa eiia?an?a. Iniaenoi
iaienai? ? i?aeaioiaeai? aei ae?oeo 38 iaoeiaeo i?aoeue, a ni?aaaoi?noa?
— 5 ?ia?o.

CI?NO ?IAIOE

Caaaeueia oa?aeoa?enoeea ianoaaeaieo oai?eo

? iaoiaee aeine?aeaeaiiy

I?iaaaeaii eiiieaenia ee?i?ei — aoi?aae?iioee?aeia aeine?aeaeaiiy o 325
ae?oae c AI, ye? e?eoaaeeny ii ?aeeiei noaiai iaoiaaiaoe/ii? oa?ai?? a
?inoeooo? o?ieia?? oa iao?ieia?? AII Oe?a?ie. Na?aae 143 ianoaaeaieo c
aino?ei AI o 104 ae?aaiinoiaaii iao?ioe/iee neiae?ii, o 39 — ci?oaio
oi?io AI (iao?ioe/iee neiae?ii c aaiaoo???th oa/aai a?ia?oaic??th).
O?ii?/iee AI anoaiiaeaii o 182 oai?eo, na?aae ieo c IO — 138, ?c CO —
44. A?e ae?oae a?ae 3 aei 15 ?ie?a, oeii/eee neeaaeaee 58,2%, ae?a/aoea
— 41,8%.

An?i oai?ei cae?eniaii oi?o?eiaaiee eiiieaen ee?i?ei — eaai?aoi?ieo,
a?io?i?/ieo, ?ioiieia?/ieo, aoi?aae?iioee?aeieo aeine?aeaeaiue a
aeeiai?oe? iaoiaaiaoe/ii? oa?ai??: a ia??iae aeoeaieo i?iya?a AI aei
e?eoaaiiy; iai?ee?ioe? canoinoaaiiy iaeneiaeueieo aeic AE ? OeN; ia oii?
oeeeeiaiai e?eoaaiiy AE oa i?aeo?eioth/eo aeic OeN; a eaoaiiac? i?ney
a?aei?ie oa?ai??.

Anueiai c?iaeaii 1733 aeine?aeaeaiiy: ?aae?iioee?aeieo ?i a?ai — 261,
?i a?o?i — 1124, oeueo?acaoeiaeo — 348 (oaae.1). O 55 ae?oae
eiio?ieueii? a?oie aeeiiaii 227 aeine?aeaeaiiy.

Aeeiai?/io noeeioea?ao?th aeeiioaaee ia aaiia — eaia?? PHO GAMMA LFOV,
yea neiiieaeoiaaia c eiii’thoa?ii PDP 11/34 (DEK), ca?aeii c
caaaeueiiaeciaieie iaoiaeeeaie.

Aeey ioe?iee noaio iae?ioaaaeueii? nenoaie ia/?iee oa
aioo??oiueiia/?ieiai? aaiiaeeiai?ee aeei?enoiaoaaee ANA c 99iOn —
eiei?aeii. Ioe?ithaaee ne?aeoth/e iieacieee ANA: eiinoaioa ?aoaioe?? o
e?ia? (E?E); eiinoaioa ?aoaioe?? o ia/?ioe? (E?I); ?iaeaen ia/?ieiaiai
caoaaoo (?IC); aeiey naeac?iee (AeN); ?ioaa?aeueiee iae?ioaaaeueiee
?iaeaen (OAI); aoaeoeaiee ia/?ieiaee e?iaiieei (AIE) .

Oaaeeoey 1

Ianya aeeiiaieo aeine?aeaeaiue i?e aeiia?oeiiao?eo? o ae?oae

Iaoiaeeee K?euee?noue aeine?aeaeaiue

A?oie ianoaaeaieo Anueiai aeine?aeaeaiue

Aino?ee AI O?ii?/iee AI Kiio?ieueia a?oia

1. Caaaeueia eieueeinoue eeiii/ieo aeineiaeaeaiue 136 189 55 380

2. Aaiaoinoeeioea?aoiy c 99mOn — eieiiaeii 40 67 20 127

3. Aaiaoiaieinoeeioea?aoiy c 99mOn -IACEAeA 61 93 20 174

?aaeiiiiioiieiai/iee aiaeic:

4. Xieieaeioeei 61 93 20 174

5. Aano?ei 36 57 15 108

6. Nae?aoei 36 57 15 108

7. Aetheaaii 36 57 15 108

8. N — iaioeae 36 57 15 108

9. Iinoeii 36 57 12 105

10. ?a/iaeia ? 36 57 10 103

11. O?einei 36 57 15 108

12. AII 36 57 10 103

13. OII 13 19 — 32

14. Niiaoinoaoei 12 16 — 28

15. Eaeoeei — aieaoaeii 24 39 — 63

16. b — aiaei?oii 11 13 — 24

17. oeAIO 34 45 10 89

18. Aoiaeiiiea?ia?aoiy 56 118 30 204

19. Niiia?aoiy iiaeoeoieiai? caeice 56 118 20 194

Aeey ioe?iee aeia/iooai?aiiy oa aeia/iaeae?eaiiy aeeiioaaee AANA c
99mOn — IACEAeA. Aiae?coaaee ne?aeoth/e iieacieee: ?iaeaen ia/?ieiaiai
caoaaoo (?IC), a?aenioie ?aae?ioa?ii?aia?aoo (?OI), yeee aeaiaeeoueny ?c
ia/?iee iai?ee?ioe? aeine?aeaeaiiy (Ai%), /an iaaeoiaeaeaiiy ?OI a
aeia/iee i?oo? (Oi), eaoaioiee /an (Oe), iieaciee aaaeoaoi?ii?
caeaoiino? aeia/iiai i?oo?a (Ai%), iiaeaeueia eiinoaioa oaeaeeino?
ia?aoiaeo ?OI ?c ieacie a aaiaoioeeo (E12).

?aae?iioee?aei? eiio?ieuei? aeine?aeaeaiiy i?iaaaeaii o 20 ae?oae a?eii
a?ae 5 aei 14 ?ie?a, ianoaaeaieo /a?ac 3 — 5 ?ie?a i?ney ia?aianaiiai
a??oniiai aaiaoeoo A (eaaeee ia?aa?a) aac ee?i?ei — a?io?i?/ii? oa
oeueo?acaoeiai? neiioiiaoeee o?aaeaiiy ia/?iee.

?aae?i?ioiieia?/iee aiae?c aeia/ieo eeneio oa aano?i?ioanoeiaeueieo
ai?iii?a, o?eineio (aeea. oaae.1) cae?eniaii ca?aeii c ?ino?oeoe?yie
o??i — aeaioiaethaa/?a. ?aae?iiao??th i?ia aeeiioaaee ca aeiiiiiaith
aaiia — e?/eeueieea “Aaiia — 12” (N?N?).

Oeueo?acaoeia? aeine?aeaeaiiy ia/?iee (c aoaiii AeOI) oa i?aeoeoieiai?
caeice c?iaeaii ca aeiiiiiaith aia?aoa NEI — 5000, eio?ee aeeth/a?
naeoi?iee neaia? 3,5 IAoe oa ?iioeuenio aeiiiea? — i?enoaaeo, yea
aeei?enoiaoaaeanue aeey ioe?iee ia/?ieiai? aaiiaeeiai?ee. Ioe?ithaaee
iao?e/i? oa aeonoe/i? oa?aeoa?enoeee ia/?iee, aeia/iiai i?oo?a, noai
noaeeiii? nenoaie (oiaueio, u?euei?noue noaeeiieo no?iie, ae?aiao?
noaeei, ia’?iiee e?iaiieei o ai??oi?e aai?, oei e?eaeo e?iaiieeio
iaoiaeii AeOI).

Aea/aee ?ici??e aie?aee, o?ea, oainoa i?aeoeoieiai? caeice, nooi?iue
aoiaaiiino? ia?aioeie.

Aeei?enoaii a?eia? ii?ie ?ici???a i?aeoeoieiai? caeice ca aeaieie
A.Aeai?yeianeiai, 1984.

Niaoeeo?ea ooieoe?iioaaiiy ia/?iee, i?aeoeoieiai? caeice, oeoieo,
ai?iiiaeueii? aano?i?ioanoeiaeueii? nenoaie ioe?ithaaeany a oiiaao ae??
iecee /eiiee?a: O1 — ia?aa?a AI; O2 — oi?ia AI; O3 -canoinoaaiiy
iaaeeeaiaioicieo i?aia?ao?a; O4 — iayai?noue HBs — aioeaaio; O7 — a?e
oai?eo; O8 — noaoue oai?eo; O9 — noaae?y iaoiaaiaoe/iiai e?eoaaiiy; O10
-noiooi? caoai?thaaiiy; Z1- ai?iiii/ooeea?noue; Z2- aoaeoeai?noue
e?eoaaiiy; Z3 — oneeaaeiaiiy, aeyaeai? a i?ioean? e?eoaaiiy AE oa OeN;
Z4 — iia?/i? yaeua oa?ai??.

O naith /a?ao, ia?ae?/ai? /eiieee aa??ththoue ia ??cieo ??aiyo: O1 = 1
— aino?ee ia?aa?a AI; O1 = 2 — o?ii?/iee ia?aa?a AI; O2 = 1 —
iao?ioe/iee neiae?ii; O2 = 2 — IO; O2 = 3 — CO; O2 = 4 — iaiiaiee
iao?ioe/iee neiae?ii; O3 = 0 — aac aeei?enoaiiy e?ea?nueeeo i?aia?ao?a;
O3 = 1 — AE; O3 = 2 — AE oa OeN; O3 = 3 — iine?aeiaia canoinoaaiiy
i?aia?ao?a; O3 = 4 — AE oa aeaeaa?e; O4 = 1 — iayai?noue HBs — aioeaaio;
O4 = 2 — a?aenooi?noue HBs — aioeaaio; O9 = 0 — aei e?eoaaiiy; O9 = 1 —
ia noaae?? iaeneiaeueieo aeic AE oa OeN; O9 = 2 — ia noaae??
i?aeo?eioth/eo aeic; O9 = 3 — a eaoaiiac?; O10 = 0 — a?aenooi?noue
noiooi?o caoai?thaaiue; O10 = 1 — iayai?noue noiooi?o caoai?thaaiue; Z1
= 1 — ai?iiii/ooeeaee aa??aio AI; Z1 = 2 — ai?iiiicaeaaeiee; Z1 = 3 —
/anoeiai ai?iiii?acenoaioiee; Z1= 4 — ai?iiii?acenoaioiee; Z2 = 1 —
iiaia ee?i?ei- eaai?aoi?ia ?ai?n?y (IEE?); Z2 = 2 — /anoeiaa
ee?i?ei-eaai?aoi?ia ?ai?n?y (*EE?); Z2 = 3 — a?aenooi?noue aoaeoo
e?eoaaiiy (AA); Z3=0 — a?aenooi?noue oneeaaeiaiue oa?ai??; Z3 =1 —
iciaee iaaeeeaiaioiciiai aaiaoeoo; Z4 = 0 — a?aenooi?noue iia?/ieo yaeu
oa?ai??; Z4=1 — iayai?noue iia?/ieo yaeu.

Noaoenoe/io ia?iaeo ?acoeueoao?a aeine?aeaeaiiy i?iaiaeeee ia
ia?niiaeueiiio eiii’thoa?? IBM PC — Pentium ?c aeei?enooaaiiyi iaeaoo
i?ia?ai Statistica 4.3 aeey Windows (NOA).

Ine?eueee /eiieee, ye? oa?aeoa?ecothoue oai?iai ia AI, ae?aaeai? ia a
e?euee?nieo oeaeao, aeey ioe?iee iacaeaaeiino? iciae aeei?enoiaoaaee
iaia?aiao?e/i?, cie?aia ?aiaia? iaoiaee [I. Oieeaiaea?, Ae. Aoeueo,
1983, TH.I. Oth?ei, A.A. Ia?eia. 1995]. Aecia/aeeny eiao?oe??ioe
?aiaiai? ei?aeyoe?? Eaiaeaeea — t(? = 0,95 aai P < 0,05). I?iaaaeaii e?i?eiee ei?aeyoe?eiee aiae?c e?euee?nieo iieaciee?a c aecia/aiiyi eiao?oe??ioo ei?aeyoe?? I??niia - r. ?acoeueoaoe aeine?aeaeaiiy Noai iae?ioaaaeueii? nenoaie ia/?iee oa ia/?ieiai? aaiiaeeiai?ee i?e aeiia?oeiiao?eo? o ae?oae A ia??iae aeoeaieo i?iya?a AI ca ?acoeueoaoaie ANA c 99mOn -eiei?aeii aoee aeyaeai? ii?ooaiiy aioo??oiueinenoaiii? aaiiaeeiai?ee i?e aino?iio AI o 80,2%, oa i?e o?ii?/iiio AI o 89,1% aeiaaee?a. A?eueo ae?aaeaia cieaeaiiy AIE niinoa??aaeiny i?e o?ii?/iiio AI (oaae. 2). Ca ?acoeueoaoaie AeOI aecia/aeeny: aeaiooaciaa e?eaa e?iaiieeio (41,8% aeiaaee?a), oiae? ye a ii?i? ia niiia?ai? ia/?ieiaeo aai aeieoiaioo?oueny o?e oace; cieaeaiiy aiie?ooaee oacieo inoeeeyoe?e (23%); aeaoi?iaoe?y e?eai? (19,3%), ui a?aeaeaaei ii?ooaiiy ia/?ieiai? aaiiaeeiai?ee i?ae /an iaa?yeiaiai neiae?iio. O 58% ae?oae aeyaeyeiny caoaeaiiy ae?aiao?a ia/?ieiaeo aai a ii??aiyii? c a?eiaith ii?iith, o 30,6% oai?eo aecia/aeiny ou?eueiaiiy noaeeiieo no?iie ai??oii? aaie, ia?aaaaeii i?e /anoi ?aoeeaeeaoth/iio o?ii?/iiio AI. I?e aino?iio AI i?aeoe/ii o an?o oai?eo iaei i?noea i?eai?/aiiy E?I, oiae? ye i?e o?ii?/iiio AI cieaeaiiy oeueiai iieacieea aecia/aii eeoa o 44,8% iaoe??io?a ia oii? cao?eiee i/euaiiy e?ia? a?ae ?aae?ieiei?aeo. Iiaeeeai, o ae?oae, ye? aia?oa caoai??ee ia AI, iae?ioaaaeueia nenoaia i?aai?cio aia?oa noeea?oueny c ae??th iaoieia?/ieo /eiiee?a, ? ?? a?aeiia?aeia ?aaeoe?y a?eueo ae?aaeaia, i?ae i?ae /an o?ii?/iiai ia?aa?ao iao?eoo. ?icaeaa?oueny eiiiainiaaia aeieaaea iae?ioaa?a, ui ia oe? noaa?euei?oiai noaio ia/?ieiai? aaiiaeeiai?ee caaacia/o? noia?io ooieoe?th nenoaie - i/euaiiy i?aai?cio a?ae /oaei??aeieo aaaio?a. I?e aino?iio AI cieaeaiiy i/euaiiy e?ia? a?ae ?OI, iaaooue, aoei coiiaeaii ci?iith AeN. Oae, ca?aeii c na?aaeiueinoaoenoe/ieie aeaieie, AeN i?e aino?iio oa o?ii?/iiio AI ia?aaeuoaaea ii?iaeuei? cia/aiiy a 1,5 ?aco, ui na?ae/eoue i?i oa, ui nenoaia “ia/?iea - naeac?iea” i?e iao?ioe/iiio neiae?ii? AI, i/aaeaeii, ooieoe?iio? a oiiaao i?aeaeuaiieo iaaaioaaeaiue. Aeyaeaii noaoenoe/ii cia/ou? ca’ycee (? < 0,05) i?ae iieacieeaie ANA oa a?eii ae?oae (oaae. 2). Oae, iaeaeu? cia/aiiy e?iaiieeio a?aei?/aii o ae?oae iieiaeoi? a?eiai? a?oie. Iaea?eueo ae?aaeai? c?ooaiiy ia/?ieiai? aaiiaeeiai?ee a?aecia/aii o ae?oae na?aaeiueiai oa noa?oiai oe?eueiiai a?eo c o?ii?/iei, /anoi ?aoeeaeeaoth/ei ia?aa?aii CO AI. Aecia/aii aeaye? caeiiii??iino? iiaaae?iee iieaciee?a ANA o ae?oae ??cii? noao?. Iai?eeeaae, o ae?a/ao aoei a??ia?aeia (?<0,05) i?aeaeuaiiy E?E a 1,4 ?aco i?ioe ii?iaeueieo cia/aiue, oa ia?aa?eueoaiiy iieacieea ia 20% o ii??aiyii? c oeii/eeaie, ui iiaea aooe iia’ycaiei c? noaoaaei aeeii?o?ciii ia/?iee. Aiane?aeie aetheiei?oeei?aeii? oa?ai?? i?aeoe/ii o an?o oai?eo ii?iae?coaaeeny aoi?aae?iioee?aei? oanoe. O 82,1% ae?oae iieacieee na?aaeiueiai ia’?iiiai e?iaiieeio a ai??oi?e aai? i?aeaeuoaaee ii?io a 1,5 ?aco aiane?aeie ?aaoethth/i? ae?? AE ia nei?i/oaaeueio caeaoi?noue aaneoey?ieo oa a?noea?aeueieo aeaaeeeo i’yc?a /a?ac iaoai?ci i?eai?/aiiy ?o aeaeo?iiaoai?/ii? aeoeaiino?. I?e o?ii?/iiio AI oi/a ? a?aecia/aeiny iie?ioaiiy e?iaiieeio, ii??aiyeueii c aeo?aeieie aeaieie, iaeiae oeeo?e AIE ia aeinyaaee ii?ie, o 32,5% oai?eo niinoa??aaeany aeaiooaciaa e?eaa c ii?ooaiiyi eai?ia?iiai e?iaiieeio. Oaaeeoey 2 Oa?aeoa?enoeea ?aiaiai? ei?aeyoe?? (ca e?eoa???i Kaiaeaeea) i?ae iieacieeaie ANA oa aeine?aeaeoaaieie /eiieeaie i?e aeiia?oeiiao?eo? o ae?oae (?<0,05) ) ?iaaiue cia/ouinoi ? K?KE (YA1N) (ia?aaia AI) O1 107 0,151868 0,020426 EK?KE (YA1N) (noaoue oai?eo) O8 107 - 162026 0,015379 EK?I (YA2N) (ia?aaia AI) O1 107 0,206180 0,001646 K?I (YA2N) (eiea?nueei i?aia?aoe) O3 107 0,222033 0,000700 EK?I (YA2N) (aoaeo eieoaaiiy) Z2 107 - 0,149744 0,022284 K?I (YA2N) (noaaeiy eieoaaiiy) O9 107 0,153612 0,019034 K?I (YA2N) (aie oai?eo) O7 107 0,224303 0,000617 AIKE (YA4N) (ia?aaia AI) O1 107 - 0,151985 0,020329 AIKE (YA4N) (eiea?nueei i?aia?aoe) O3 107 0,250514 0,000131 AIKE (YA4N) (aie oai?eo) O7 107 - 0,160771 0,005786 AeN (YA5N) (noiooii caoai?thaaiiy)O10 107 0,162449 0,013139 YAO (oi?ia AI) O2 107 - 0,149083 0,022851 YAO (eiea?nueei i?aia?aoe) O3 107 0,129019 0,048892 Iaiao?aei?noue aaeaioaoe?? i?aai?cio aei aaeeeeo aeic ?ioiiaeai?anaio?a i?aeoaa?aeaeoaaeanue oaeiae ci?iaie E?I oa OAI, iniaeeai ia oii? iaeii/aniiai i?eeiio AE oa OeN. ?noioia cieaeaiiy E?I oa c?inoaiiy OAI a?aeaeca?eaethaaee ii?ooaiiy oaaioeeoa?ii? ooieoe?? iae?ioaa?a ?, iia’ycaia c iei, eiiiainaoi?ia ca?eueoaiiy aeoeaiino? naeac?iee. Aaaaoioaeoi?iee ei?aeyoe?eiee aiae?c aecia/ea caeaaei?noue i?ae ooieoe?iiaeueiei noaiii iae?ioaaaeueii? nenoaie oa aoaeoeai?noth e?eoaaiiy, ?icaeoeii ai?iiii?acenoaioiino?, aeieeiaiiyi oneeaaeiaiue ? iia?/ieo yaeu oa?ai??. Iecuee? cia/aiiy E?I niinoa??aaeeny o 86,6% ae?oae c ai?iiii?acenoaioiei aa??aioii AI ?c aecia/aiith *EE? aai a?aenooi?noth aoaeoo e?eoaaiiy (oaae. 2). Eiio?ieuei? niiiaeiiiea?ia?ao?/i? aeine?aeaeaiiy ia aoai? i?aeo?eioth/eo aeic AE oa OeN iieacaee ii?iae?caoe?th ai??oii? aaiiaeeiai?ee, i?ioa o 23,4% oai?eo, ia?aaaaeii i?e oi?i?aeiiio ia?aa?ao CO AI, niinoa??aaeiny cieaeaiiy oeeo? ai??oiiai e?iaiieeio ia oii? iioiauaiiy oa ou?eueiaiiy noaeeiieo no?iie oa a?eie ai??oii? aaie. O?aaa a?aei?oeoe, ui o 83,3% oai?eo ?c iao?ioe/iei neiae?iiii AI noiooi?e a??oniee aaiaoeo, iaa?oue o noaae?? ?ai?n??, ca a?aenooiino? ee?i?ei - eaai?aoi?ieo iciae o?aaeaiiy ia/?iee, ni?e/eiya a??ia?aeia i?aeaeuaiiy AeN, i?e/iio o 44,4% oai?eo - a 2,5 - 4 ?ace. O 80,3% aeiaaee?a aeieoiaiooaaeiny ou?eueiaiiy noaeeiieo no?iie a?eie ai??oii? aaie ? caa??aaeiny 3 - 9 i?nyoe?a ?ai?n?? AI oa a eaoaiiac?. No?ee? cieaeaiiy iieaciee?a ia’?iiiai e?iaiieeio aoee a e?i?ei?e ei?aeyoe?ei?e caeaaeiino? c? no?oeoo?ieie oa ooieoe?iiaeueieie iciaeaie aeoeaiino? iaoieia?/iiai i?ioeano a ia/?ioe?. A eaoaiiac? o oai?eo ?c IEE? i?ney ia?aianaiiy IO AI ii?iae?coaaeanue ooieoe?iiaeueia aeoeai?noue iae?ioaa?a (75,1% aeiaaee?a), a?aeiiaethaaeeny e?ea? e?iaiieeio (100%) oaeaee?noue ai??oiiai e?iaiieeio (81,7%). O an?o oai?eo ia CO AI caa??aaeanue aeaeiiiainiaaia aeieaaea iae?ioaa?a oa o 50% - cieaeaiiy iieaciee?a ai??oiiai e?iaiieeio. Noai aaiaoia?e?a?ii? nenoaie i?e aeiia?oeiiao?eo? o ae?oae ca aeaieie ?aae?iioee?aeieo aeine?aeaeaiue A ia??iae ?iciaeo aino?iai AI, eiee niinoa??aaeiny ia?inoaiiy iaa?ye?a ??ciiai nooiaiy ae?aaeaiino? e ?ioien?eaoe?eiee neiae?ii, i?aeoe/ii o an?o oai?eo (98,6%) ii?oooaaeany ae?yeuei?noue aaiaoia?e?a?ii? nenoaie. Ia?aa?a AI, ca aeaieie ei?aeyoe?eiiai aiae?co, cia/oua aieeaaa ia noai iaia?aie aaiaoioeeo?a, ui a?aeaeaaeiny i?aeaeuaiiyi iiaeaeueii? eiinoaioe oaeaeeino? ia?ao?aeo ?OI ?c e?ia? a aaiaoioeeo oa iaa?iaii - E12 (oaae. 3). I?enei?aiiy e?iaoeee ?OI, a?eueo cia/ii i?e o?ii?/iiio AI, iaoiiaeaii, ca iaoith aeoieith, cieaeaiiyi aaiiaeeiai?ee a ia/?ioe? oa eiiiainaoi?ieie i?ioeanaie ia ??ai? iaia?aie aaiaoioeeoa, ui aeicaiey? ee?oei? i?aeo?eioaaoe aeeoo?ae?yeuei?noue a iiaeo oiiaao. C ae?oaiai aieo, iiae?aiee noai aacaeueii? iaia?aie ia/?ieiaeo ee?oei i?e AI i?ecaiaeea aei aeaeiiiainaoe?? ?o ooieoe??, ?iceaae?a iaoaaie?/ieo oa e?iaoe/ieo i?ioean?a a aaiaoioeeoao, ui ni?e/eiy? ii?ooaiiy neioaco oa e?iaoeee iio?aeieo oieanoa?eio-aeia/ieo eeneio. Ca?aeii c aeaieie ??A ci?ie OA a ne?iaaooe? e?ia? a??ia?aeii a?aecia/aii o 92% oai?eo, /ano?oa - i?e o?ii?/iiio AI. I?aeaeuaiiy ??aiy OA iaei i?noea i?e an?o oi?iao AI, aea aoei a?eueo ae?aaeaiei o ae?oae ?c CO (ia 25% aeua a?ae ii?iaeueiiai ??aiy). Aeyaeaii caeaaeiino? i?ae ??aiai OA o e?ia? oa iayai?noth ?aoeeaeea?a AI a aiaiiac?. Oaeeueiiiae?aiee, /anoi ?aoeeaeeaoth/ee ia?aa?a caoai?thaaiiy noi?iaiaeaeoaaany a?eueo ae?aaeaiei oieanoacii. Ia aeeeth/aii, ui ia na?aaeiueinoaoenoe/i? cia/aiiy OA aieeioa cia/iee a?aenioie o oe??? a?oie iaoe??io?a ?c HBs-aioeaaiai??th oa noiooi?i o?aaeaiiyi ia/?iee, ia?aaaaeii a??oniiai iioiaeaeaiiy. Ei?aeyoe?eiee aiae?c i?aeoaa?aeea aieea (P<0,05) iayaiino? iiaa?oiaaiai aioeaaio a??oniiai aaiaoeoo A ia aacaeueio iaia?aio aaiaoioeeo?a (oaae. 3). O HBs-iiceoeaieo iaoe??io?a E12 i?aeoe/ii ia ci?ithaaeany, oiae? ye o ae?oae aac HBs-aioeaaiai?? E12 i?aeaeuoaaeany ia 30-40%. A?aenooi?noue i?enei?aiiy e?iaoe/ieo i?ioean?a, ye? ?aae?cothoueny /a?ac aacaeueio iaia?aio, na?ae/eoue i?i ?? ?acenoaioi?noue aei o?eaaeiai aieeao a??onieo aaaio?a. Ae?y iaoieia?/iiai i?ioeano a ie?eao a?aeaeaaeany ia noai? aeae?eueii? ooieoe?? aeia/iiai i?oo?a, yeo a?aeaeca?eaeth? Ai%. Iaea??o? cia/aiiy iieacieea niinoa??aaeeny i?e CO o?ii?/iiai AI o ae?oae c oaeeueiiiae?aiei ?aoeeaeeaoth/ei ia?aa?aii caoai?thaaiiy (oaae. 3). Ca aeaieie aoia?ao?? o 38,4% oai?eo aeieoiaioiaai? aeaoi?iaoe?? aeia/iiai i?oo?a, ye? a 10% aeiaaee?a noi?iaiaeaeoaaeeny iciaeaie caiaethaaeueiiai i?ioeano. O ae?oae ?c caaino?aiiyi o?ii?/iiai AI (27%), ye? iaee a aiaiiac? o?e oa a?eueoa eo?n?a aetheiei?oeei?aeii? oa?ai?? a ca’yceo c ai?iiiicaeaaeiei aa??aioii caoai?thaaiiy, a?aecia/aeiny ca?eueoaiiy ?ici???a aeia/iiai i?oo?a. Oaaeeoey 3 Oa?aeoa?enoeea ?aiaiai? ei?aeyoe?? (ca e?eoa???i eaiaeaeea) i?ae ?aae?iioee?aeieie iieacieeaie oa aeine?aeaeoaaieie /eiieeaie i?e aeiia?oeiiao?eo? o ae?oae (?<0,05) Cay'cie ia?e ciiiieo *enei niinoa?aaeaiue Eiaoioei?io ei?aeyoei? Eaiaeaeea t ?iaaiue cia/ouinoi ? IIC (eiea?nueei i?aia?aoe) O3 154 - 0,1763 0,0011 IIC (ai?iiii/ooeeainoue) Z1 154 - 0,1205 0,0264 IIC (aie oai?eo) O7 154 0,1193 0,0280 IIC (noaaeiy eieoaaiiy) O9 154 0,1094 0,0439 IIC (oneeaaeiaiiy) Z3 154 - 0,1859 0,0006 A % (oneeaaeiaiiy) Z3 154 - 0,1172 0,0308 Ai % (ia?aaia AI) O1 154 - 0,1091 0,0445 Ai % (oi?ia AI) O2 154 - 0,1104 0,0419 Ai % (eiea?nueei i?aia?aoe) O3 154 - 0,1310 0,0158 Ee12 (ia?aaia AI) O1 154 0,1139 0,0359 Ee12 (HBs-aioeaai) O4 154 0,1178 0,0300 OA (ia?aaia AI) O1 154 0,1520 0,0051 OA (oi?ia AI) O2 154 0,1588 0,0034 OA (eiea?nueei i?aia?aoe) O3 154 0,2351 0,0000 OA (HBs-aioeaai) O4 154 - 0,2057 0,0001 OA (ai?iiii/ooeeainoue) Z1 154 0,2103 0,0001 OA (aoaeo eieoaaiiy) Z2 154 0,2246 0,0000 OA (noiooii caoai?thaaiiy) O10 154 0,2941 0,0000 OA (oneeaaeiaiiy) Z3 154 0,2626 0,0000 I?ae /an iaoiaaiaoe/ii? oa?ai?? AI ciaeaeaia oaiaeaioe?y aei cieaeaiiy a?aeiia?aeieo ?aaeoe?e c aieo aaiaoia?e?a?ii? nenoaie, ui ciaeoei a?aeaeoie a ??ciiiai?oieo ci?iao ?aae?iioee?aeieo iieaciee?a (oaae. 3). Canoinoaaiiy AE a iaeneiaeueieo aeicao i?aeoe/ii ia ci?ithaaei aeo?aeiiai ??aiy ?IC o ae?oae an?o a?eiaeo a?oi. Ia oii? canoinoaaiiy AE oa OeN aeieoiaiooaaeiny cieaeaiiy iaeiie/oaaiiy ?OI a ia/?ioe?, a?eueoa o oai?eo a?eii a?ae 3 aei 7 ?ie?a ?c CO o?ii?/iiai AI, ai?iiii?acenoaioiei aa??aioii caoai?thaaiiy. Nooo?aa i?eai?/aiiy ooieoe?iiaeueii? cae?aiino? iie?aiiaeueieo ee?oei niinoa??aaeiny ia aoai? i?aeo?eioth/eo aeic AE oa OeN o iaoe??io?a iieiaeoiai a?eo. Aeioe?eueii a?aecia/eoe, ui a eaoaiiac? i?ney a?aei?ie e?eoaaiiy a noaae?? ?ai?n?? AI o 50% ae?oae i?inoaaeoaaeanue ii?iae?caoe?y ooieoe?? aaiaoioeeo?a, aea ?? a?aeiiaethaaiiy, a cia/i?e i???, aoei oa?aeoa?ia aeey a?oie noa?oiai oe?eueiiai a?eo. O ae?oae iieiaeoiai a?eo iaeiie/oaaeueia ooieoe?y iie?aiiaeueieo ee?oei caeeoaeany cieaeaiith. A aeeiai?oe? oa?ai?? cia/ii i?eai?/oaaeany nei?i/oaaeueia ooieoe?y aeia/iiai i?oo?a, cia/aiiy Ai% cieaeoaaeeny a 2,5-3 ?ace a ii??aiyii? c eiio?ieai. Iaea??o? iieacieee ciaeaeai? o oai?eo ?c CO, ye? aaaaoi?aciai io?eioaaee eo?ne iaoiaaiaoe/ii? oa?ai?? c i?eaiaeo ?aoeeaeeaoth/iai ia?aa?ao o?ii?/iiai AI. Ooieoe?iiaeueii a?aeeeth/aiee aeia/iee i?oo? (17,5% aeiaaee?a) cao?eniaaii ia aoai? iaeneiaeueieo aeic AE oa OeN o ae?oae c iiaaiei aoaeoii e?eoaaiiy. A?iioii?y aeia/iiai i?oo?a, ca ?acoeueoaoaie AANA, noi?iaiaeaeoaaeany o?eaaeith ae?eyoaoe??th i?aaia o 32% ae?oae ca aeaieie aoia?ao??. I?aeo?eioth/e aeice ?ioiiaeai?anaio?a ua a a?eueo?e i??? ii?oooaaee noai aeia/iaeae?ethaaeueii? nenoaie. AEia/iee i?oo? ia a?coae?coaaany o 23% ae?oae, niinoa??aaany oa?i?iiaee niaci no?ieoa?o ia/?ieiai? i?ioiee oa a?iioii?y no?ieoa?o aaeeeiai aeoiaeaiaeueiiai ninea. Ae?y AE aeaui i?aeaeuoaaea ??aaiue OA o e?ia? ia?aaaaeii o ae?oae c o?ii?/iei ia?aa?aii AI oa CO. A?eueoee nooi?iue ?icaeoeo oieanoaco niinoa??aaany i?e iaeii/aniiio i?eeiaii? AE oa OeN. Aeeiai?/i? niinoa?aaeaiiy i?aeoaa?aeeee a?eueo ae?aaeaiee ?icaeoie oieanoaco ia aoai? i?aeo?eioth/eo i?aia?ao?a ? ii?iae?caoe?th OA a eaoaiiac? o 76% ae?oae. Aenieee ??aaiue aeia/ieo eeneio aecia/aii o iaoe??io?a ?c noiooi?ie caoai?thaaiiyie ia/?iee, HBs-aioeaaiai??th, iaaeeeaiaioiciei aaiaoeoii (oaae. 3), a oaeiae o i’yoe ae?oae ?c CO o?ii?/iiai AI. Aeyaeai? caeiiii??iino? ci?i ??aiy OA aiae?coaaeeny c o?aooaaiiyi ??cii? ai?iiii/ooeeaino? oai?eo (oaae. 3). Ii?iaeuei? cia/aiiy aeacaiiiai iieacieea aeieoiaioiaaii o ai?iiiicaeaaeieo oa ai?iiii/ooeeaeo iaoe??io?a ia oe? IEE?, i?e ai?iiiicaeaaeiiio aa??aio? AI i?ae /an *EE? a?i ia?aaeuoaaa ii?io ia 15%, o ai?iiii?acenoaioieo oai?eo - aoa iaeaeuei. Ua iai/i?oa i?inoaaeoaaany ?icaeoie oieanoaco i?e aiae?c? aoaeoo e?eoaaiiy (oaae. 3). Iaeaeueie aoee cia/aiiy aeia/ieo eeneio o ae?oae c *EE? oa AA, ui na?ae/eoue i?i iayai?noue o ieo cia/iiai oieanoaco, coiiaeaiiai, iaaooue, aieeaii iani?eyoeeai? oi?ie caoai?thaaiiy (ye i?aaeei, CO), a oaeiae aaaaoie?aoieie eo?naie ?ioiiaeai?aneaii? oa?ai??. Aa?oi cacia/eoe, ui ia?aaaaeii oai?? c noiooi?ie a??onieie caoai?thaaiiyie ia/?iee oa iaaeeeaiaioiciei aaiaoeoii ia aoaiao e?eoaaiiy AE oa OeN iaee iaeaeuee ai?no a e?ia? OA, yeee a 4-5 ?ac?a ia?aaeuoaaa ii?io. I?eaa?oa? oaaao oie oaeo, ui o 35,2% aeiaaee?a c?inoaiiy eiioeaio?aoe?? OA ei?aethaaei (P<0,05) ?c aacneiioiiiei i?aeaeuaiiyi ??aiy ia/?ieiaeo oa?iaio?a a e?ia? i?ae /an oa?ai??. Aecia/ai? i?e oeueiio iecuee? iieacieee AANA (?IC oa A%) i?aeoaa?aeaeothoue cieaeaiiy iaeiie/oaaeueii-aeae?eueii? ooieoe?? ia/?iee ? ?icaeoie aioo?eoiueiee?oeiiiai oieanoaco, ui aea? i?aenoaae aeoiaoe i?i aeeaie? iaia?aii? ii?ooaiiy oa aeenooieoe?th aiaeiieaciaoe/iiai ?aoeeoeoio aaiaoioeeo?a o oai?eo ia AI ae?oae aiane?aeie o?eaaeiai aaeeaaiiy ?ioiiaeai?anaio?a. Ioaea, ?acoeueoaoe ee?i?ei-?aae?iioee?aeieo niinoa?aaeaiue aee?eee aoyaiaiiy ia/?iee a caaaeueiee iaoieia?/iee i?ioean i?e IO AI, ci?ie ?? ooieoe?? i?ae ae??th AE oa OeN, aca?iica’ycie i?ae noaiii aaiaoioeeo?a, aeia/iiai i?oo?a oa aoaeoeai?noth e?eoaaiiy. Anoaiiaeaia caeiiii??i?noue ci?i aaiaoia?e?a?ii? nenoaie i?e iayaiino? noiooiueiai a??oniiai o?aaeaiiy ia/?iee, a oaeiae iaaeeeaiaioiciiai aaiaoeoo. Aecie?eiia oa aiaeie?eiia ooieoe?y i?aeoeoieiai? caeice i?e aeiia?oeiiao?eo? o ae?oae I?iaaaeai? ?aae?i?ioiieia?/i? aeine?aeaeaiiy iaie?aaoe/ieo ai?iii?a oa oa?iaio?a aeyaeee a??ia?aei? ii?ooaiiy aecie?eiii? oa aiaeie?eiii? ae?yeueiino? i?aeoeoieiai? caeice ia aoaiao iaoiaaiaoe/ii? oa?ai?? AI (oaae 4). A ia??iae ?iciaeo AI o 90% ae?oae, iacaeaaeii a?ae oi?ie oa ia?aa?ao caoai?thaaiiy, aacaeueia eiioeaio?aoe?y o?eineio a e?ia? cieaeoaaeany a 4 - 5 ?ac?a a ii??aiyii? c ii?iith, ui aeaco? ia aoyaiaiiy i?aeoeoieiai? caeice a caaaeueiee iaoieia?/iee i?ioean, cieaeaiiy nae?aoe?? o?eineio, iiaeeeai, aiane?aeie a?iii?ioa?iai??, cano?eieo yaeu oa aeenoee?eoeyoi?ieo ?iceaae?a i?e iao?ioe/iiio neiae?ii?, ye? ii?ooothoue nae?aoi?iee eiiaae?? a aoeeia?ieo ee?oeiao. O 90% oai?eo niinoa??aaeeny ci?ie ?ie?aoi?ii? ooieoe?? o aeaeyae? aacaeueii? ?inoe?iai?? (??aaiue ?inoe?io ia?aaeuoaaa ii?io a 2-4 ?ace), ui a?aeaeaa? ii?ooaiiy aoaeaaiaeiiai iai?io, iaoaaie?/i? oa ai?iiiaeuei? aeenooieoe??, ye? noi?iaiaeaeothoue iao?ioe/iee neiae?ii. Ii?yae c oeei, ii?iiae?eai?th ia oii? a?ia??inoe?iai?? iiaeia iiynieoe ?inoe?iiaith ?acenoaioi?noth ia?eoa??eieo oeaiei. O 60% ae?oae caaeieoiaioiaaii a?iiaetheaaiiai?th (na?aaei? cia/aiiy ai?iiia aoee ieae/a ca ii?io ia 45%), iiaeeeai, iia’ycaio c i?eai?/aiiyi a-ee?oei i?aeoeoieiai? caeice oa/aai ?ici??ii aeiaiai? i?ioa?io???, yea aeinyaaea 6,5a. A ia??iae canoinoaaiiy ?ioiiaeai?anaio?a aecie?eiia ooieoe?y i?aeoeoieiai? caeice cia/ii aeoea?coaaeany (oaae. 4) , o 45,8% oai?eo ??aaiue o?eineio a e?ia? a??ia?aeii ia?aaeuoaaa ii?io, a?eueo nooo?ai ia aoai? e?eoaaiiy iaeneiaeueieie aeicaie AE. A?ia?oa?iaioai?y na?ae/eoue i?i ?icaeoie aeeniaie?aaoecio, yeee iaa iai?ioiee oa?aeoa? o ia?aaaaeii? e?eueeino? ae?oae. Iaea?eueo aenie? cia/aiiy oa?iaioo, ye? niinoa??aaeeny o aeayeeo oai?eo, ye i?aaeei, ia oii? oa?/iai? nain?a?e?caoe??, noi?iaiaeaeoaaeeny ee?i?/iith neiioiiaoeeith oa na?ae/eee i?i ?icaeoie aeeniaie?aaoecio /e ?aaeoeaiiai iaie?aaoeoo. Ia i?aeo?eioth/eo aeicao i?aia?ao?a ??aaiue o?eineio, ca na?aaeiueinoaoenoe/ieie aeaieie, ii?iae?coaaany, ii?yae c oeei o 20% oai?eo, ye? iaeii/anii io?eioaaee AE oa OeN, eiioeaio?aoe?y oa?iaioo aoea aeaui i?aeaeuaiith. Ia aoai? iaeneiaeueieo oa i?aeo?eioth/eo aeic AE oa OeN a?ia??inoe?iai?y niinoa??aaeany o 100% oai?eo. Iaea?eueo? a?aeoeeaiiy ?inoe?io, ye? a 3-5 ?ac?a ia?aaeuoaaee eiio?ieuei? iieacieee, ciaeaeaii o ae?oae a?eii 3 - 7 ?ie?a, ia?aaaaeii c aino?ei ia?aa?aii caoai?thaaiiy. Oaaeeoey 4 Oa?aeoa?enoeea ?aiaiai? ei?aeyoe?? (ca e?eoa???i eaiaeaeea) i?ae o?eineiii, aetheaaiiii, N-iaioeaeii, ?inoe?iii oa aeine?aeaeoaaieie /eiieeaie i?e aeiia?oeiiao?eo? o ae?oae (?<0,05) Ca'ycie ia?e ciiiieo *enei niinoa?aaeaiue eiaoioei?io ei?aeyoei? eaiaeaeea (t) ?iaaiue cia/ouinoi ? O?einei (eiea?nueei i?aia?aoe) O3 93 0,1775 0,0117 O?einei (noaaeiy eieoaaiiy) O9 93 0,1863 0,0082 O?einei (noaoue oai?eo) O8 93 0,1589 0,0240 N -iaioeae (iiai/ii yaeua) Z4 93 0,1643 0,0096 Aetheaaii (eiea?nueei i?aia?aoe) O3 93 0.2644 0,0001 Aetheaaii (noaaeiy eieoaaiiy) O9 93 0,2088 0,0030 Aetheaaii (iiai/ii yaeua) Z4 93 - 0,2563 0,0002 Iinoeii (aoaeo eieoaaiiy) Z2 93 0,1502 0,0329 Iinoeii (aie oai?eo) O7 93 - 0,1778 0,0115 Iinoeii (noaaeiy eieoaaiiy) O9 93 - 0,3094 0,0000 Iinoeii (iiai/ii yaeua) Z4 93 0,1799 0,0106 Aeyaeaii caeaaei?noue i?ae ??aiai ?inoe?io o e?ia? oa aoaeoii e?eoaaiiy: *EE? oa AA noi?iaiaeaeoaaeeny a?eueo ae?aaeaiith ?inoe?iai??th a ii??aiyii? c IEE?. A ia??iae iaoiaaiaoe/ii? oa?ai?? o 70,8% oai?eo i?aeaeuoaaany ??aaiue aetheaaiio a e?ia?, a?eueo cia/ii i?ae aieeaii iaeii/aniiai canoinoaaiiy AE oa OeN. Iii??ia aetheaaiiai?y caeeoaeany o 56% iaoe??io?a ? ia i?aeo?eioth/eo aeicao. Ciaeaeaii caeiiii??iino? (P<0,05) i?ae ci?iaie iaie?aaoe/ieo ai?iii?a oa ?icaeoeii iia?/ieo yaeu oa?ai?? (oaae. 4). I?aeaeuaiiy eiioeaio?aoe?? a e?ia? ?inoe?io, N-iaio?aeo, cieaeaiiy aetheaaiio noi?iaiaeaeoaaei yo?iaaiiee neiioiiieiiieaen Eooeiaa. Ii?ooaiiy ooieoe?iiaeueieo ?aca?a?a a-ee?oei i?aeoeoieiai? caeice, iiaeeeai, i?aeo?eio?oueny aoe?i??th, yea aeeeeeaia AE, oa aeicaiey? ?aeiiaiaeoaaoe iaiaaeoaaeueio ae??oo e aeiciaaia oa?/oaaiiy a ia??iae canoinoaaiiy iaeneiaeueieo aeic i?aaeiecieiio. O ia?aaaaeii? e?eueeino? oai?eo ia IO AI, ye? iaee HBs-aioeaaiai?th, iaaeeeaiaioiciee aaiaoeo, neiae?ii oeeoie?co, i?inoaaeoaaeany oaiaeaioe?y aei a?ia??inoe?iai??, ui a?aeaeaa? nooo?ao ?ieue ia/?iee uiaei iaoaaie?cio ?inoe?io. A eaoaiiac? o 58,3% ae?oae ooieoe?y aoeeia?iiai aia?aoo noaa?e?coaaeany, o 37,5% aeiaaee?a niinoa??aaeany iii??ia a?iio?eineiai?y ia?aaaaeii i?e ai?iiii?acenoaioiiio aa??aio? AI i?ae /an *EE?. O 68% ae?oae oe??? a?oie aeieoiaiooaaeany HBs-aioeaaiai?y. Ii?iae?caoe?y ?ie?aoi?ii? ooieoe?? caeice o a?eueoino? iaoe??io?a na?ae/eoue i?i aeinoaoi? ?aca?ai? iiaeeeaino? i?aai?cio, a?eueo ae?aaeai? o iieiaeo?e a?eia?e a?oi?. I/aaeaeii, niia?eueiaiiy a?aeiiaeaiiy ?inoe?io a e?ia? o ae?oae na?aaeiueiai oa noa?oiai a?eo iaoiiaeaii o?ii?/iei ia?aa?aii AI, iaiaeii?aciaeie eo?naie iaoiaaiaoe/ii? oa?ai??, eio?a ni?e/eiy? a?ia?ieac?th an?o no?oeoo? i?aeoeoieiai? caeice ? ci?iaiiy ?o ooieoe?iiaeueiiai noaio. Iacaaaeath/e ia ??ciini?yiiaai?noue niinoa??aa?ieo c?ooaiue aecie?eiii? oa aiaeie?eiii? ooieoe?? i?aeoeoieiai? caeice i?e AI o ae?oae, iiaeia i?eionoeoe, ui aiie, ia?aaaaeii, iathoue eiiiainaoi?ii-i?enoinoaaeueiee oa?aeoa?, oa ni?eythoue i?aeo?eioe? aiiainoaco ia ?aaoeyoi?iiio oa ai?iiiaeueiiio ??aiyo. Iniaeeaino? aano?i?ioanoeiaeueiiai noaoono i?e aeiia?oeiiao?eo? o ae?oae O a?eueoino? ae?oae c AI aeyaeai? nooo?a? ci?ie aano?i?ioanoeiaeueieo ai?iii?a caeaaeii a?ae aeoeaiino? iaoieia?/iiai i?ioeano a ie?eao. A aeoeai?e oac? aino?iai oa o?ii?/iiai AI o 90% oai?eo niinoa??aaeiny a??ia?aeia (P<0,05) ciaioaiiy aacaeueiiai aano?eio a e?ia? a ii??aiyii? c eiio?ieai (oaae. 5). A?iiaano?eiai?y caeaaeaea a?ae ?ici???a aeiaiai? i?ioa?io??? oa, ?iia??ii, aoea iaoiiaeaia i?eai?/aiiyi aano?eiae?iaeyth/eo ee?oei ? ii?ooaiiyi aaiiaeeiai?ee neeciai? iaieiiee oeoieo ia oe? iaa?yeiaiai neiae?iio. Iiae?aia oaiaeaioe?y i?inoaaeaia a ci?iao A?I oa ?a/iaeie ?, ui a?aeaeaaeiny cieaeaiiyi ??ai?a oeeo ai?iii?a o 90% aeiaaee?a, a?eueo cia/ii i?e aino?iio AI. Ui noino?oueny nae?aoeio, oi i?e iayaiino? i?aeoe/ii ii?iaeueieo na?aaeiueinoaoenoe/ieo cia/aiue, 45% ae?oae iaee iii??ia cieaeaiiy oeueiai iieacieea, aaee/eia yeiai ciaoiaeeeany a caeaaeiino? a?ae nooiaiy i?ioa?io???. Iai?ee?ioe? iaeneiaeueieo aeic AE oa OeN ii i??? auooaiiy ie?eiaiai i?ioeano ia?aeaeueii ciaioaiith ee?i?/ieo i?iya?a AI oa ii?iae?caoe?? eaai?aoi?ieo iieaciee?a, a?aeaoaaeany iinooiiaa iiceoeaia aeeiai?ea aano?eio o 33,4% ae?oae. O 41,6% oai?eo aano?ei i?aeaeuoaaany a 3-4 ?ace a ii??aiyii? c aeo?aeieie aeaieie, iniaeeai i?ae aieeaii iaeii/aniiai canoinoaaiiy AE oa OeN. Iaea?eueo? cia/aiiy aano?eio i?inoaaeaii o 16,6% ae?oae c /anoi ?aoeeaeeaoth/ei ia?aa?aii AI, *EE?, ii?ooaiiyi acioiaeae?eueii? ooieoe?? ie?ie. A?aeaoaaany oaeiae c??no nae?aoeio o 2,2 ?ace a ii??aiyii? c ii/aoeiaei ??aiai. O 41,2% aeiaaee?a a?ia?nae?aoeiai?y noi?iaiaeaeoaaeany a?ia?aano?eiai??th, a ?aoo? aeiaaee?a ci?ie ai?iii?a - aioaaii?no?a iaee ??ciini?yiiaaiee oa?aeoa?. Oaaeeoey 5 Oa?aeoa?enoeea ?aiaiai? ei?aeyoe?? (ca e?eoa???i eaiaeaeea) i?ae aano?eiii, nae?aoeiii, ?a/iaeiith ?, A?I oa aeine?aeaeoaaieie /eiieeaie i?e aeiia?oeiiao?eo? o ae?oae (?<0,05) Cay'cie ia?e ciiiieo *enei niinoa?aaeaiue Eiaoioei?io ei?aeyoei? Eaiaeaeea t ?iaaiue cia/ouinoi ? Aano?ei (eiea?nueei i?aia?aoe) O3 93 0,3049 0,0000 Aano?ei (noaaeiy eieoaaiiy) O9 93 0,3046 0,0000 Aano?ei (oneeaaeiaiiy) Z3 93 - 0,1545 0,0282 Nae?aoei (eiea?nueei i?aia?aoe) O3 93 0,0298 0,0008 ?a/iaeia ?(eiea?nueei i?aia?aoe) O3 93 0,2313 0,0010 ?a/iaeia ? (aoaeo eieoaaiiy) Z2 93 0,1590 0,0239 AII (eiea?nueei i?aia?aoe) O3 93 0,2331 0,0009 I?ae aieeaii iaoiaaiaoe/ii? oa?ai?? a?aeaoaaeiny i?aeaeuaiiy ??ai?a o e?ia? ?a/iaeie ?, A?I,O?I, niiaoinoaoeio, yea a?aeaeaa? aoaeoe iaaeeeoeo AE uiaei ci?ie ia?aiao??a ooieoe?iioaaiiy aiaeie?eiieo ee?oei o?aaii? nenoaie oa noai?aiiy iaaaeaeaaoieo oiia aeey ae?yeueiino? aa?oi?o a?aeae?e?a o?aaiiai eaiaeo. Iie?oaa?y, yea aeieeaea ia oeueiio oe?, iineethaaea aeenaaeain oeoieiai? nae?aoe??. I?aeaeuaiiy aeoeaiino? ai?iiiiaeoeaieo ee?oei ne?ciai? iaieiiee oeoieo, ae?iaeyth/eo aano?ei, ei?aethaaei c ??aiai o?iiaineio a na/?. Ia i?aeo?eioth/eo aeicao i?aia?ao?a aeyaeyeany oaiaeaioe?y aei ii?iae?caoe?? i?aeoe/ii an?o aano?i?ioanoeiaeueieo ai?iii?a. I?ioa o aeayeeo oai?eo caeeoaeeny ??ciiiai?oi? ci?ie ?aaoethth/eo iaioeae?a a e?ia?, ye? ia iaee ei?aeyoe?? ?c aea/a?ieie /eiieeaie. Anoaiiaeaia oaiaeaioe?y (P<0,05) aei cieaeaiiy aano?eio i?e iayaiino? oneeaaeiaiue (aano?iaeoiaeai?o, ae?acea oeoieo), ye? aeieeaee i?ae /an canoinoaaiiy iaeneiaeueieo aeic AE oa OeN (oaae.5). ?iia??ii, aiia iaoiiaeaia c?eaii eiiiainaoi?ii-i?eeaooiaieo ?aaeoe?e o i?ioean? aeniaaeaiiy ?o ?aca?aieo iiaeeeainoae ? aeenaaeainii oaeoi??a aa?an?? oa caoenoo a neecia?e iaieiioe? oeoieo, ui iio?aao? i?iaaaeaiiy niaoe?aeueieo aeine?aeaeaiue. A eaoaiiac? /a?ac ??e i?ney a?aei?ie oa?ai?? o a?eueoino? iaoe??io?a niinoa??aaeany noaa?e?caoe?y ??aiae aano?eio, ?a/iaeie ?, A?I. I?ioa o oai?eo ia CO ?c ai?iiii?acenoaioiei aa??aioii AI, *EE? oa AA caa??aaeeny iii??i? ??ciini?yiiaai? ii?ooaiiy eiioeaio?aoe?? ai?iii?a o e?ia?. Oaeei /eiii, aeeiai?/i? ee?i?ei-?aae?i?ioiieia?/i? niinoa?aaeaiiy aeyaeee, ui AE oa OeN iaeii/anii i?aeaeuothoue ye ??aaiue aano?eio, noeioethth/iai oeoieiao nae?aoe?th, oae ? eiai aioaaii?no?a - nae?aoeio, A?I, ye? i?eai?/othoue nae?aoe?th nieyii? eeneioe. Oaea i?iii?oe?eia c?inoaiiy eiioeaio?aoe?? aanoi?ioanoeiaeueieo ai?iii?a c aioaaii?noe/ieie aeanoeainoyie iiaea aooe i?e/eiith ci?ie ae?yeueiino? o?aaiiai eaiaeo o ae?oae a aeeiai?oe? iaoiaaiaoe/ii? oa?ai??. I?ioa ia aeeeth/aii, ui iiae?ai? a?aeiia?aei? ?aaeoe?? c aieo ?aaoethth/eo iaioeae?a a?aeaeaathoue eiiiainaoi?ii-aaeaioaoe?eio ?aaeoe?th i?aai?cio ia aieea no?ani?iiai oaeoi?o - ?ioiiaeai?aneaii? oa?ai??. Aeoea?caoe?y aiaeie?eiii? nenoaie o?aaiiai eaiaeo ia aoaiao e?eoaaiiy AI oa?aeoa?eco? ci?io ooieoe?? eiaeiiai oeio ee?oei oa eiie?aoieo i?aai?a, iniaeeaino? aeiaai/aniaiai aoaio aaeaioioe?? nenoaie o?aaeaiiy aei o?eaaeiai canoinoaaiiy aaeeeeo aeic AE oa OeN. ?acoeueoaoe oeueo?acaoeiaiai aeine?aeaeaiiy i?aeoeoieiai? caeice i?e aeiia?oeiiao?eo? o ae?oae A ia??iae aeoeaieo ee?i?/ieo i?iya?a IO AI ia oe? iaa?ye?a ca aeaieie aoia?ao?? o 28% iaoe??io?a niinoa??aaeiny aeeoocia ca?eueoaiiy ?ici???a i?aeoeoieiai? caeice, a?eueo ae?aaeaia i?e o?ii?/iiio ia?aa?ao AI, ia?aaaaeii o ae?oae a?eii a?ae 3 aei 6 ?ie?a. O oai?eo ia CO AI ca?eueoaiiy ?ici???a caeice a?aeaoaaeiny o an?o a?eiaeo a?oiao. O?aaa a?aei?oeoe, ui ia an?o aoaiao aeine?aeaeaiiy ?ici??e aie?aee, o?ea, oainoa i?aeoeoieiai? caeice ciaoiaeeeeny a e?i?ei?e caeaaeiino? a?ae a?eo, aeinyaath/e iaeaeueo ia?aiao??a o ae?oae noa?oi? a?oie (oaae. 6). Iaeii/anii niinoa??aaeany noaoaaa ??cieoey i?aeoeoieiai? caeice (oaae. 6), yea i?iyaeyeany aeae?eueea a?eueoeie ?ici??aie i?aaia o ae?a/ao an?o a?eiaeo a?oi a ii??aiyii? c oeii/eeaie, a?eueo cia/ii o a?oe? 14 - 15 ?ie?a. Ia aoai? canoinoaaiiy iaeneiaeueieo aeic AE oa OeN a ia??iae noaa?e?caoe?? AI a 30,2% aeiaaee?a caaeieoiaioiaaii ca?eueoaiiy i?aeoeoieiai? caeice, /ano?oa aie?aee oa oainoa. O 20,8% oai?eo ci?ithaaany no?oeoo?iee noai caeice, ui a?aecia/aeiny i?aeneeaiiyi aoiaaiiino?, iaiaeii?iaei?noth ia?aioeie (oaae. 6). Iniaeeai iai/ii ou?eueiaiiy ia?aioeie i?inoaaeaii i?e iiaaiiio aoaeo? e?eoaaiiy o ai?iiii?acenoaioieo iaoe??io?a. O ae?oae iieiaeoiai a?eo ou?eueiaiiy caeice noi?iaiaeaeoaaei aeeoocia aai eieaeueia ca?eueoaiiy caeice, a na?aaeiuei? oa noa?oi? a?eiaeo a?oiao iaei ia?aaaao i?aeneeaiiy aoiaaiiino? ia?aioeie ii?yae c ii?iaeueieie ?ici??aie i?aaio, aai eieaeueiei ca?eueoaiiyi aie?aee oa oainoa. I?e eiio?ieueieo aeine?aeaeaiiyo a ia??iae i?aeo?eioth/eo aeic AE oa OeN o 40,4% oai?eo caeeoaeeny ??ci? ii?oieia?/i? ci?ie caeice. O ae?oae 3 - 6 ?ie?a niinoa??aaeeny o?ioe ca?eueoai? ?ici??e i?aaio, a a?oi? ae?oae 7 - 13 ?ie?a ci?ie, ia?aaaaeii, i?noeeeny a ou?eueiaii? ia?aioeie, iaiaeii?iaeiino? aoino?oeoo?e ca ?aooiie neeueieo aoineaiae?a, ?iciianthaeaeaiieo ii anueiio ia’?io caeice. Ci?ie aoino?oeoo?e niinoa??aaeeny ia?aaaaeii o ae?oae c *EE?, a?aenooi?noth aoaeoo e?eoaaiiy, oi?i?aeiei ia?aa?aii oai?iae. Caa?oa? ia naaa oaaao oie oaeo, ui o oai?eo c aaeeeith e?euee?noth ?aoeeaeea?a AI, /anoeie eo?naie iaoiaaiaoe/ii? oa?ai?? ou?eueiaiiy ia?aioeie ii?aeioaaeiny ?c ciaioaiiyi ?ici???a oainoa caeice. Oaaeeoey 6 Oa?aeoa?enoeea ?aiaiai? ei?aeyoe?? (ca e?eoa???i eaiaeaeea) i?ae ?ici??aie aie?aee, o?ea, oainoa i?aeoeoieiai? caeice, aoiaaii?noth ia?aioeie oa aeine?aeaeoaaieie /eiieeaie i?e aeiia?oeiiao?eo? o ae?oae (?<0,05) Cay'cie ia?e ciiiieo *enei niinoa?aaeaiue Eiaoioei?io ei?aeyoei? Eaiaeaeea t ?iaaiue cia/ouinoi ? Y1 (ia?aaia AI) O1 174 0,179 0,0004 Y1 (oi?ia AI) O2 174 0,179 0,0004 Y1 (ai?iiii/ooeeainoue) Z1 174 0,145 0,0046 Y1 (aoaeo eieoaaiiy) Z2 174 0,117 0,0221 Y1 (aie oai?eo) O7 174 0,453 0,0000 Y1 (noaoue oai?eo) O8 174 - 0,165 0,0012 Y1 - (iiai/ii yaeua) Z4 174 - 0,103 0,0424 Y2 (ia?aaia AI) O1 174 0,234 0,0000 Y2 (oi?ia AI) O2 174 0,172 0,0007 Y2 (aoaeo eieoaaiiy) Z2 174 0,116 0,0226 Y2 (aie oai?eo) O7 174 0,415 0,0000 Y2 (noaoue oai?eo) O8 174 -0,170 0,0008 Y2 (noiooii caoai?thaaiiy) O10 174 -0,114 0,0257 Y3 (ia?aaia AI) O1 174 -0,146 0,0041 Y3 (oi?ia AI) O2 174 0,169 0,0009 Y3 (HBS-aioeaai) O4 174 0,101 0,0468 Y3 (ai?iiii/ooeeainoue) Z1 174 0,110 0,0304 Y3 (aoaeo eieoaaiiy) Z2 174 0,116 0,0229 Y3 (aie oai?eo) O7 174 0,376 0,0000 Y3 - (noaaeiy eieoaaiiy) O9 174 0,115 0,0244 Y4 - (eiea?nueei i?aia?aoe) O3 174 -0,124 0,0152 Y4 (ai?iiii/ooeeainoue) Z1 174 -0,131 0,0101 Y4 (aie oai?eo) O7 174 -0,133 0,0092 Ciaeaeaii ei?aeyoe?eiee ca’ycie (P<0,05) i?ae ci?iaie i?aeoeoieiai? caeice ? noiooi?ie caoai?thaaiiyie aaiaoia?e?a?ii? nenoaie, HBs-aioeaaiai??th, a oaeiae yo?iaaiiei neiae?iiii Eooeiaa (oaae.6). Iayai?noue oeeo oaeoi??a ni?eyea a?aeiiniiio ciaioaiith aie?aee, o?ea, oainoa caeice a ii??aiyii? c ?ici??aie i?aaia o oai?eo ia AI oiai ae a?eo aac aeaii? iaoieia??. A eaoaiiac? o a?eueoino? ae?oae c AI niinoa??aaeany cae/aeia aoia?ao?/ia ea?oeia caeice. A oie aea /an o 17,7% iaoe??io?a caeeoaeiny eieaeueia aaiaeeoocia ca?eueoaiiy i?aaia. Ou?eueiaiiy ia?aioeie aeieoiaiooaaeiny o 20% ae?oae c ??aiith /anoioith o an?o a?eiaeo a?oiao. Ca?eueoaiiy i?aeoeoieiai? caeice, ye i?aaeei, eieaeueia, ca ?aooiie aie?aee aai oainoa aecia/aeiny o ae?oae c oa?/iaith aea?a??th. ssei? iaaoaeue a??ia?aeii? caeaaeiino? ii?oieia?/ieo ci?i i?aeoeoieiai? caeice a?ae ae?aaeaiino? ai?iiiaeueieo oa oa?iaioieo c?ooaiue ia aeyaeaii. I?ioa, o aeayeeo oai?eo ?c ci?iaieie ia?aiao?aie caeice a?aeaeaaeeny ??ciini?yiiaai? ii?ooaiiy cacia/aieo iieaciee?a, ia?aaaaeii a ia??iae canoinoaaiiy iaeneiaeueieo aeic AE oa OeN. Oaeei /eiii, ee?i?ei-aoia?ao?/i? aeine?aeaeaiiy i?aeoeoieiai? caeice a aeeiai?oe? e?eoaaiiy AI aeicaieythoue aeaanoe, ui ia caaaeath/e ia iai?ioi?noue no?oeoo?ieo ii?ooaiue, o iaai?e e?eueeino? iaoe??io?a caeeoathoueny ii?oieia?/i? ci?ie i?aaio ia aoai? i?aeo?eioth/eo aeic ? a eaoaiiac?, ui iaaaoeaii aieeaa? ia aoaeoeai?noue oa?ai??, o?eaae?noue ?ai?n?? oa iio?aao? aeeniaina?iiai niinoa?aaeaiiy ca oe??th eaoaai???th oai?eo. Ae?aaiinoe/iee aeai?eoi ianoaaeaiiy I?iaaaeai? ee?i?ei-aoi?aae?iioee?aei? aeine?aeaeaiiy aecia/eee ae?aaiinoe/i? e?eoa??? ia i?aenoaa? iieaciee?a ANA, AANA, aoia?ao?? i?aeoeoieiai? caeice ? ia/?iee c aoaiii AeOI, ai?iii?a oa oa?iaio?a i?aeoeoieiai? caeice ? ?aaoeyoi?ieo iaioeae?a o?aaiiai eaiaeo aeicaieeee ?ic?iaeoe aeaioaoaiiee aeai?eoi (oaae. 7), yeee aeioe?eueii aeei?enoiaoaaoe a ia??iae canoinoaaiiy iaeneiaeueieo aeic AE oa OeN (3-4 oeaeaeaiue a?ae ii/aoeo i?eeiio i?aia?ao?a) aeey aecia/aiiy oai?eo c ?eceeii aeieeiaiiy iaaeeeaiaioicieo o?aaeaiue i?aai?a o?aaeaiiy. ?icaeyiaii aeaye? eaiee aeai?eoio. I?aeaeuaiiy OA a e?ia? a 2 oa a?eueo ?ace, ciaeaeaia ia ia?oiio aoai? ianoaaeaiiy, yaey?oueny e?eoa???i ae?aaiinoeee oieanoaco ia aeiee?i?/iiio ??ai? oa iio?aao? iiaeeaeaiiiai aea/aiiy noaio aaiaoia?e?a?ii? nenoaie ca aeiiiiiaith AANA (ae?oaee aoai). Nooo?aa cieaeaiiy ooieoe?? aaiaoioeeo?a (?IC ieae/a 1,9±0,1), ii?ooaiiy nei?i/aiiy aeia/iiai i?oo?a (Ai% iaio i?ae 30%) yaeythoueny aeeaaiinoe/ieie iciaeaie i?eai?/aiiy ooieoe?? ia/?ieiai? ia?aioeie, ?icaeoeo aeene?iac?? aeia/iiai i?oo?a, ye? iaoiiaeai? aieeaii oa?ai??. O aeayeeo oai?eo AANA aeicaiey? aecia/eoe ooieoe?iiaeueii a?aeeeth/iee aeia/iee i?oo? oa ?io? aa??aioe aeene?iac?? aeia/ieo oeyo?a, ci?ie no?ieoa?iiai aia?aoo a?e?a?iiai o?aeoo. Ciaeaeai? ii?ooaiiy iio?aaothoue ei?aaoth/i? oa?ai?? (aaiaoii?ioaeoi?e, aeia/iaiii? caniae, oieaoeenoie?iaoeee, aioa?ini?aaioe). O aeiaaeeo aecia/aiiy ii?iaeueiiai ??aiy OA a e?ia? iaiao?aeii iiaoi?eoe aiae?c /a?ac 3 oeaeiy. Ii?iaeuei? iieacieee AANA ia oe? a?ia?oie?eae?oeeiai?? ia aeeeth/athoue ?icaeoeo ?iceaaeo noaio ia/?iee, oiio a iiae?ai?e neooaoe?? iio??ai? eiio?ieuei? ?aae?iioee?aei? aeine?aeaeaiiy ia aoai? iaeneiaeueieo oa/aai i?aeo?eioth/eo aeic AE ? OeN. Aecia/aia ca aeaieie aeoieaeniiai OCAe (ia?oee aoai) cieaeaiiy ia/?ieiaiai e?iaiieeio ia oe? aeeoocii? iaiaeii??aeiino? ia?aioeie oa ou?eueiaiiy noaeeiieo no?iie iio?aao? iiaeaeueoeo aeine?aeaeaiue - ANA c 99mOn-eiei?aeii (ae?oaee aoai). Ciaeaeai? i?iaiinoe/ii iani?eyoeea? ci?ie ?aae?iioee?aeieo iieaciee?a (AIE, E?I, AeN) na?ae/aoue i?i ii?ooaiiy iae?ioaaaeueii? nenoaie ia/?iee, eio?? a??ia?aeii a?aeaeaathoue ooieoe?iiaeueiee noai i?aaia a oe?eiio ? iio?aaothoue ci?i oaeoeee e?eoaaiiy AI, a oaeiae i?eioneathoue canoinoaaiiy cania?a, ni?yiiaaieo ia ii?iae?caoe?th noaeeiiiai oiiono, noaa?e?caoe?? aiiainoaco oiui. Oaeei /eiii, aeaiee ae?aaiinoe/iee aeai?eoi aeicaiey? ia?iaaceaieie iaoiaeaie aecia/eoe aeiee?i?/i? iioeiaeaeaiiy i?aai?a o?aaeaiiy a aeeiai?oe? e?eoaaiiy AI o ae?oae, caiia?aoe ?icaeoeo o?ii?caoe?? i?ioeano, ciaioeoe e?euee?noue ?iaaceaieo iaoiae?a aeine?aeaeaiiy. AENIIAEE 1. Eiiieaenia canoinoaaiiy i?iiaiaaeo iaoiae?a aeine?aeaeaiiy (??A, aeeiai?/ia noeeioea?ao?y, OCAe c aoaiii AeOI) aeicaiey? ia’?eoeaii ioe?ieoe ooieoe?iiaeueiee noai aaiaoia?e?a?ii? nenoaie, iae?ioaaaeueii? nenoaie ia/?iee oa naeac?iee, aioo??oiueiia/?ieiai? aaiiaeeiai?ee, aecie?eiii? ? aiaeie?eiii? aeoeaiino? i?aeoeoieiai? caeice oa aecia/eoe aano?i?ioanoeiaeueiee noaoon ye ia aoai? ia?aeiii? ae?aaiinoeee AI o ae?oae, oae ? i?ae aieeaii iaoiaaiaoe/iiai e?eoaaiiy. Ia?iaea io?eiaieo ?acoeueoao?a ?c canoinoaaiiyi oaeoi?iiai aiae?co na?ae/eoue i?i o?niee aca?iica’ycie i?ae noaiii i?aai?a o?aaeaiiy oa aoaeoeai?noth e?eoaaiiy AI, ?icaeoeii oneeaaeiaiue oa noiooi?o yaeu ?ioiiaeai?aneaii? oa?ai??. 2. Oa?aeoa? ci?i iieaciee?a ANA, AANA, ??A, AeOI a ia??iae aeoeaieo i?iya AI o ae?oae na?ae/eoue i?i aoyaiaiiy a caaaeueiee iaoieia?/iee i?ioean an?o no?oeoo? ia/?iee . Ei?aeyoe?eiee aiae?c aeyaea ??cieoeth aoi?aae?iioee?aeieo iieaciee?a o ae?oae ??ciiai a?eo oa noao?, ui aeaco? ia iayai?noue a?eiai? niaoeeo?ee aaiiaeeiai?ee, iai?io ?a/iaei, noaoaaiai ooieoe?iiaeueiiai aeeii?o?cio ia/?iee. 3. I?iaiinoe/ii iani?eyoeeaeie ?aae?iioee?aeieie e?eoa??yie aacia?a?aii ?aoeeaeeaoth/iai o?ii?/iiai ia?aa?ao AI ? iieacieee ooieoe?iiaeueiiai noaio iae?ioaa?a ia/?iee (E?I, E?E), aaiaoia?e?a?ii? nenoaie (E12, Ai%, ??aaiue OA a e?ia?), ia/?ieiai? aaiiaeeiai?ee (AIE), ci?iaiiy yeeo a?aeaeaathoue ia o?eueee i?aaii? ii?ooaiiy, aea ? nooi?iue iie?i?aaiii? iaaeinoaoiino? o oai?eo AI. 4. Iaoiaaiaoe/ia oa?ai?y aieeaa? ia ia?aiao?e ia/?ieiaiai e?iaiieeio ? noai eoioa?iaeo ee?oei. Aetheiei?oeei?aee a iaeneiaeueieo aeicao i?enei?ththoue aoi?aae?iioee?aei? aaiiaeeiai?/i? iieacieee, iniaeeai o ae?oae iieiaeoiai a?eo, aia?oa caoai??aoeo ia AI. A??ia?aei? ci?ie E?I, ocaaaeueiaiiiai iae?ioaaaeueiiai ?iaeaeno oa, iia’ycaia c ieie, c?inoaiiy AeN, a?aeaeaathoue noai i?aeaeuaiieo ooieoe?iiaeueieo iaaaioaaeaiue o nenoai? ia/?iea - naeac?iea. 5. I?ae aieeaii iaoiaaiaoe/ii? oa?ai?? noai aaiaoia?e?a?ii? nenoaie ci?ith?oueny ia iaeiaeiai. Aetheiei?oeei?aee ia /eiyoue iioeiaeaeoth/i? ae?? ia ia/?ieo; oeeoinoaoeee a??ia?aeii i?eai?/othoue ooieoe?iiaeueiee noai aaiaoioeeo?a, aeeeeeath/e oieanoac. Noeoiia canoinoaaiiy ? aetheiei?oeei?ae?a ? oeeoinoaoee?a i?ecaiaeeoue aei cia/iiai cieaeaiiy iioi?ii? ooieoe?? aeia/iiai i?oo?a, iniaeeai ia aoai? i?aeo?eioth/eo aeic. Eiiieaenia ?aae?iioee?aeia aeine?aeaeaiiy aaiaoia?e?a?ii? nenoaie aeicaiey? nai?/anii ae?aaiinooaaoe iaaeeeaiaioiciee aaiaoeo, iniiaieie ia?ea?aie yeiai ? cieaeaiiy iieaciee?a AANA (?IC oa A%) ? i?aeaeuaiiy eiioeaio?aoe?? oie?eae?oeeio o e?ia?. 6. Iaeii/ania ?aae?i?ioiieia?/ia aeine?aeaeaiiy ai?iiiiae?iaeyth/i? ooieoe?? a- ? b- ee?oei, aoeeia?iiai aia?aoo i?aeoeoieiai? caeice aeyaey? a?iio?eineiai?th (60%), a?ia??inoe?iai?th (90%) oa aeaco? ia aoyaiaiiy i?aaia a caaaeueiee iaoieia?/iee i?ioean. ??ciini?yiiaai?noue c?ooaiue a aiaeie?eii?e oa aecie?eii?e ooieoe?yo i?aeoeoieiai? caeice i?e AI o ae?oae ia? eiiiainaoi?ii-i?eeaooiaiee oa?aeoa? oa ni?ey? caa?aaeaiith aiiainoaco. 7. Oeueo?acaoeiaa aeine?aeaeaiiy c aaaaoioaeoi?iei ei?aeyoe?eiei aiae?cii ?acoeueoao?a aeicaiey? aecia/eoe iniaeeaino? no?oeoo?ieo ci?i i?aeoeoieiai? caeice a caeaaeiino? a?ae ooieoe?iiaeueiiai noaio ie?ie oa ?iaeea?aeoaeueieo oa?aeoa?enoee iaoe??io?a. No?eea ca?eueoaiiy iao?e/ieo ia?aiao??a niinoa??aa?oueny i?e ci?oai?e oi?i? o?ii?/iiai AI. A?eia? oa noao?a? iniaeeaino? iaie?aaoiaoia?ao?? i?noyoueny a ca?eueoaii? c a?eii an?o ?ici???a caeice, a?eueo o ae?a/ao noa?oiai oe?eueiiai a?eo. 8. Aetheiei?oeei?aee oa oeeoinoaoeee a iaeneiaeueieo oa?aiaaoe/ieo aeicao /eiyoue no?ani?iee aieea ia on? ee?oeii? no?oeoo?e i?aeoeoieiai? caeice, yeee a?aeaeaa?oueny ca?eueoaiiyi oee?eoeyoe?? a e?ia? iaie?aaoe/ieo ai?iii?a ? oa?iaio?a. I?iaiinoe/ii iani?eyoeeaei uiaei ?icaeoeo aeeniaie?aaoecio aai ?aaeoeaiiai iaie?aaoeoo ? cia/ia i?aeaeuaiiy o?eineio a e?ia?. I?aeaeuaiiy ai?noo a e?ia? ?inoe?io, N - iaioeaeo, cieaeaiiy aetheaaiio ia? ei?aeyoe?th c ?icaeoeii yo?iaaiiiai neiioiiieiiieaeno Eooeiaa. A?iiaetheaaiiai?y i?aeo?eio?oueny aoe?i??th, yea aeeeeeaia oa?ai??th aetheiei?oeei?aeaie, ui aeicaiey? ?aeiiaiaeoaaoe noai?ee oa?/iaee ?aaeei c iaiaaeaiiyi eaaeicanaiy?ieo aoaeaaiae?a ia ia??iae e?eoaaiiy. 9. Ia?aa?a iao?ioe/ii? oa ci?oaii? oi?ie AI o ae?oae noi?iaiaeaeo?oueny ci?iith eiioeaio?aoe?? aano?i?ioanoeiaeueieo ai?iii?a o ne?iaaooe? e?ia?. I?ae /an ?icai?iooeo i?iya aino?iai AI oa caaino?aiiy o?ii?/iiai AI cieaeaiiy ??aiae a e?ia? aano?eio, A?I, ?a/iaeie ?, nae?aoeio aecia/a?oueny aeoeai?noth i?ioeano a ie?eao, ia?o ca ana, nooiaiai i?ioa?io???. I?ae aieeaii iaoiaaiaoe/ii? oa?ai?? a?aeaoaa?oueny cia/ia aeoea?caoe?y aano?i?ioanoeiaeueiiai noaoono, ui aeyaey?oueny iaeii/aniei i?aeaeuaiiyi eiioeaio?aoe?? a e?ia? aano?eio oa eiai aioaaii?no?a o 1,5 - 2 ?ace. Oneeaaeiaiiy noa?i?aeii? oa oeeoinoaoe/ii? oa?ai?? (ae?acea oeoieo, aano?eo), ye? ciaeaeai? o 4,3% ae?oae, noi?iaiaeaeothoueny a?iiaano?eiai??th, ui na?ae/eoue i?i c?ea eiiiainaoi?ieo oa ?aca?aieo iiaeeeainoae aano?eiae?iaeyth/eo ee?oei ? aeenaaeain oaeoi??a aa?an?? oa caoenoo a neecia?e iaieiioe? oeoieo. 10. Ia aeinyaiaiiy aeia?iai aoaeoo e?eoaaiiy IO AI o ae?oae iaaaoeaii ni?eythoue cia/iee oieanoac, ianoaa?euei?noue a?aeiia?aeii? ?aaeoe?? iae?ioaaaeueii? nenoaie, no?eea a?ia??inoe?iai?y, aeacoth/a ia ?icaeoie ?inoe?iiai? iaaeinoaoiino?, ca?eueoaiiy ?ici???a ? ci?iaiiy aeonoe/ieo aeanoeainoae ia?aioeie i?aeoeoieiai? caeice. No?eea caa?aaeaiiy cacia/aieo ii?ooaiue ia aoaiao iaoiaaiaoe/ii? oa?ai?? iio?aao? o?eaaeiai aeeniaina?iiai niinoa?aaeaiiy oa nenoaie i?io?eaeoe/ieo caoiae?a aeey oe??? eaoaai??? oai?eo. 11. Ia i?aenoaa? ?ioaa?aeueii? ioe?iee noaio i?aai?a o?aaeaiiy i?e AI o ae?oae ?ic?iaeaii aeai?eoi canoinoaaiiy i?iiaiaaeo iaoiae?a aeine?aeaeaiiy aeey noi?iaiaeaeaiiy iaoiaaiaoe/ii? oa?ai??. Ia?oee aoai aeai?eoio aeeth/a? ?aae?i?ioiieia?/ia aecia/aiiy eiioeaio?aoe?? a e?ia? aeia/ieo eeneio, aano?eio, aetheaaiio oa OCAe i?aeoeoieiai? caeice ? ia/?iee c aoaiii AeOI. Ae?oaee aoai ia?aaeaa/a? i?iaaaeaiiy aeeiai?/ii? noeeioea?ao?? ia/?iee, ?aae?i?ioiieia?/iiai oanooaaiiy iaie?aaoe/ieo ai?iii?a ? oa?iaio?a, aiaeineii?/ia oa ?io? niaoe?aeuei? aeine?aeaeaiiy aa?oi?o a?aeae?e?a o?aaiiai eaiaeo. Ae?aaiinoe/ia oaeoeea canoinoaaiiy iaai?o cai?iiiiiaaieo aeey eiaeiiai aoaio iaoiae?a caaacia/o? ciaioaiiy e?eueeino? ia’?io aeiaeaoeiaeo aeine?aeaeaiue aeey aecia/aiiy iaoieia?? i?aai?a o?aaeaiiy i?e AI o ae?oae oa aeicaiey? nai?/anii canoiniaoaaoe ei?eaoth/o oa?ai?th. NIENIE IAOEIAEO ?IAIO, IIOAEIEIAAIEO CA OAIITH AeENA?OAOeI? 1. Oaiani/oe - Aaaee?aa I.A., Aaaaeana?iaa I.A., Iaaiia Ae.Ae., Iineaeaiei I.I., Aieee I.E. Ooieoeiiiaeueiee i no?oeoo?iee noai ia/iiee i?e iao?ioe/iiio neiae?iii o aeioae //Iaaeiao?iy, aeooa?noai i aiiaeieiaiy. -1993.- ? 4.- N. 15 - 19. 2.Eaca? A.I., Oaiani/oe - Aaaee?aa I.A., Aaaaeana?iaa I.A., Aieee I.E., Iaaiia Ae.Ae. I?iiaiaaa aeiaaiinoeea noaio ia/iiee i?e iao?ioe/iiio noaii o aeioae // O?AE. -1993. - ?4. - N. 257 -261. 3. Oaiane/oe - Aaaeeaaa I.A. Eeeieei - yoia?aoe/aneay ioeaiea ninoiyiey iiaeaeaeoaei/iie aeaeacu i?e aeiia?oeiiao?eoa o aeaoae //A?oea eeeie/. e yenia?ei. iaaeeoeeiu. - 1997. - O. 6, ? 2. - N. 12 -16. 4.Oaiane/oe - Aaaeeaaa I.A Yiaeie?eiiay ooieoeey iiaeaeaeoaei/iie aeaeacu a aeeiaieea ea/aiey aeiia?oeiiao?eoa o aeaoae //A?oea eeeie/.. e yenia?ei. iaaeeoeeiu. -1997. - O. 6, ? 2. - N. 8-11. 5. Iniaaiiinoe nae?aoeee o?eineia i?e aeiia?oeiiao?eoa o aeaoae ia yoaiao iaoiaaiaoe/aneie oa?aiee //A?oea eeeie/. e yenia?ei. iaaeeoeeiu.- 1988.-O.7, ?2.- N. 216-218. 6. Oaian?/oe - Aaaee?aa I.A. Aeiiiea?ioeoiiao??y a ?ici?ciaaaii? noaeeiieo ii?ooaiue ia/?iee i?e aeiia?oeiiao?eo? o ae?oae //Ee?i?/. oa aenia?ei. iaaeeoeeia. - 1997.- ? 3 - 4. - N. 7 - 8. 7. Oaian?/oe - Aaaee?aa I.A. Iniaeeaino? aano?i?ioanoeiaeueiiai ai?iiiaeueiiai noaoono i?e aeiia?oeiiao?eo? o ae?oae //Ee?i?/. oa aenia?ei. iaaeeoeeia. - 1997. - ? 3 - 4. - N.17 - 18. 8. Oaian?/oe - Aaaee?aa I.A. Noai iae?ioaaaeueii? nenoaie ia/?iee oa ia/?ieiai? aaiiaeeiai?ee i?e aeiia?oeiiao?eo? o ae?oae ca aeaieie aaiaoinoeeio?a?ao?? c 99i On - eiei?aeii //O?AE. - 1997.-O. 5, ? 4. - N. 356-359. 9.Oaian?/oe - Aaaee?aa I.A. ?aae?i?ioiieia?/ia ioe?iea oieanoaco ia aoaiao iaoiaaiaoe/ii? oa?ai?? aeiia?oeiiao?eoo o ae?oae //O?AE. - 1997. - O. 5, ? 4.-N. 353 -355. 10. Oaian?/oe - Aaaee?aa I.A. Aeaye? iieacieee ooieoe?iiaeueiiai noaio i?aeoeoieiai? caeice o ae?oae c iao?ioe/iith oi?iith aeiia?oeiiao?eoo // I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y. Ca. iaoe. ?ia?o Anioe?aoe?? ?aae?ieia?a Oe?a?ie. - Ee?a, 1997. - N. 122 - 124. 11. Oaian?/oe - Aaaee?aa I.A. Iniaeeaino? nae?aoe?? aano?eio a i?ioean? iaoiaaiaoe/ii? oa?ai?? aeiia?oeiiao?eoo o ae?oae //I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y. Ca. iaoe. ?ia?o Anioe?aoe?? ?aae?ieia?a Oe?a?ie. - Ee?a, 1997. - N. 125 - 127. 12.Oaian?/oe - Aaaee?aa I.A. Oeueo?acaoeiaa aeineiaeaeaiiy i?aeoeoieiai? caeice i?e aeiia?oeiiao?eo? o ae?oae ia aoaiao iaoiaaiaoe/iiai eieoaaiiy // I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y. Ca. iaoe. ?ia?o Anioe?aoe?? ?aae?ieia?a Oe?a?ie. - Ee?a, 1997. - N. 114 - 115. 13. Oaian?/oe - Aaaee?aa I.A. Ci?ie aeayeeo aano?i?ioanoeiaeueieo ai?iii?a i?e aeiia?oeiiao?eo? o ae?oae // I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y. Ca. iaoe. ?ia?o Anioe?aoe?? ?aae?ieia?a Oe?a?ie. - Ee?a, 1998. - N. 225 - 227. 14. Oaian?/oe - Aaaee?aa I.A. Noai i?aeoeoieiai? caeice i?e aeiia?oeiiao?eo? o ae?oae // I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y. Ca. iaoe. ?ia?o Anioe?aoe?? ?aae?ieia?a Oe?a?ie. - Ee?a, 1998. - N. 228 - 230. 15. Oaiane/oe - Aaaeeaaa I.A. Ooieoeeiiaeueiia ninoiyiea iae?ioaaaeueiie nenoaiu ia/aie i?e iao?ioe/aneii neiae?iia o aeaoae //Cae?aaiio?aiaiea Aeiiaanna.-1996.-?1.-N. 63 - 70. 16. Oaiane/oe - Aaaeeaaa I.A. Ooieoeeiiaeueiay oa?aeoa?enoeea ninoiyiey ia/aie i?e iao?ioe/aneii neiae?iia o aeaoae //Iiaeia?iaeii oi?o?ai/ii aeii aeey iieiaeeo a/aieo: Oac. aeii. - Ee?a, 1993. - N. 125 - 126. 17. Oaiane/oe - Aaaeeaaa I.A. ?aaeeieiioiiua iniaaiiinoe aano?ieioanoeiaeueiiai noaoona i?e aeiia?oeiiao?eoa o aeaoae //Oac. aeii. Oe?. eiia?ano ?aaeiieiaia. - Ee?a, 1995. - N. 120. 18.Oaiane/oe - Aaaeeaaa I.A., Aieee I.E. ?aaeeiioeeeaeiua e niiiaeiiiea?ia?aoe/aneea eciaiaiey ia/aie i?e aeiia?oeiiao?eoa o aeaoae //Oac. aeii. Oe?. eiia?ano ?aaeiieiaia. - Ee?a, 1995. - N. 121. 19. Tanasichuk - Gazhieva N.V., Moskalenko N.I. Functional characteristics of liver state with nephrotic syndrome in children //30 - th Congress European Society of Pediatric Radiology. - London (UK), 1993. - ?. 47. 20.Tanasichuk - Gazhieva N.V. Peculiarities of structural - functional state of liver with glomerulonephritis in children //New Trends in Hepatology: Falk Symposium ? 92. - St. Petersburg (Russia), 1996.- ?. 208. 21. Tanasichuk - Gazhieva N.V. Structure - function changes in liver in glomerulonephritis associated with hepatitis B surface antigen immune complex //10 th Asian - Pacific Congress of Gastroenterology. - Yo kohama (Japan), 1996. - ?. 294. 22. Tanasichuk - Gazhieva N.V. Bile acids are an early marker of drug impairment of the liver in glomerulonephritis immunodepressive therapy //Bile Acid in Hepatobiliary Diseases. Basis Research and Clinical Application: XIY Intern. Bile Acid Meeting, Falk Symposium ? 93.- Freiburg (Germ.), 1996. - P. 153. 23. Tanasichuk - Gazhieva N.V. Functional state of liver under the influences of pathogenetic therapy of glomerulonephritis in children // New Trends in Diagnosis and Treatment of Liver and Colonic Diseases: Belorussian - Polish - Ukranian Falk Symposium, Lviv (UKR), 1997. - P. 373. 24.Aieee I.E., Iaothoei ?.I., Oaian?/oe - Aaaee?aa I.A. Aeiaaiinoeea iaoiaeii aeoieaenaoia?aoii ii?ooaiue ia/iieiaii aaiiaeeiaiiee i?e aeiia?oeiiao?eoi o aeioae: - Iioi?iaoe?eiee eeno. - Ee?a, 1993. - 2n. AIIOAOe?ss Oaian?/oe - Aaaee?aa I.A. ?ioaa?aeueia oa?aeoa?enoeea noaio ia/?iee, i?aeoeoieiai? caeice, oeoieo i?e aeiia?oeiiao?eo? o ae?oae (ee?i?ei - aoi?aae?iioee?aei? aeine?aeaeaiiy). - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.23 - i?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y. - Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey, Ee?a, 1998. Ia i?aenoaa? eiiieaeniiai ee?i?ei - aoi?aae?iioee?aeiiai ianoaaeaiiy ae?oae c iao?ioe/iith oa ci?oaiith oi?iaie aeiia?oeiiao?eoo aea/ai? iniaeeaino? no?oeoo?ii - ooieoe?iiaeueiiai noaio ia/?iee, i?aeoeoieiai? caeice, oeoieo, noai ai?iiiaeueiiai aano?i?ioanoeiaeueiiai noaoono a i?ioean? iaoiaaiaoe/ii? oa?ai??. Ia aac? aaaaoioaeoi?iiai ei?aeyoe?eiiai aiae?co aecia/aii aca?iica’cie ii?ooaiue noaio i?aai?a o?aaeaiiy c oyaee?noth ia?aa?ao aeiia?oeiiao?eoo, aoaiii aetheiei?oeei?aeii? oa oeeoinoaoe/ii? oa?ai??, aa?eaioii ai?iiii/ooeeaino?, aoaeoii e?eoaaiiy. Aecia/aii ?aii? ia?ea?e iiaeeeaeo oneeaaeiaiue oa iia?/ii? ae?? aetheiei?oeei?ae?a ? oeeoinoaoee?a. C?iaeaii iaa?oiooaaiiy aioaiiiai aeine?aeaeaiiy oai?eo ca aeiiiiiaith ?ic?iaeaiiai eiiieaeno aoi?aae?iioee?aeieo iaoiae?a, aeiaaaeaii iaiao?aei?noue e?eoaaeueii - i?io?eaeoe/ieo caoiae?a, iaa?oue a ia??iae ee?i?ei - eaai?aoi?ii? ?ai?n??. Anoaiiaeaii, ui canoinoaaiiy ae?aaiinoe/iiai aeai?eoio, caniiaaiiai ia aeei?enoaii? ?aae?i?ioiieia?/iiai aiae?co, aoia?ao??, aeiiiea?ioeoiiao???, aeeiai?/ii? noeeioea?ao?? aeicaiey? ciaioeoe ianya aeine?aeaeaiue, cieceoe i?iiaiaaa iaaaioaaeaiiy ia i?aai?ci aeeoeie, a oaeiae iioei?coaaoe oa ?iaeea?aeoae?coaaoe e?eoaaiiy ae?oae oai?eo ia aeiia?oeiiao?eo. Eeth/ia? neiaa: aeiia?oeiiao?eo o ae?oae, ia/?iea, i?aeoeoieiaa caeica, oeoiie,aano?i?ioanoeiaeuei? ai?iiie, iaoiaaiaoe/ia oa?ai?y, aoi?aae?iioee?aei? iaoiaee aeine?aeaeaiiy, aoaeoeai?noue e?eoaaiiy. AIIIOAOeEss Oaiane/oe - Aaaeeaaa I.A. Eioaa?aeueiay oa?aeoa?enoeea ninoiyiey ia/aie, iiaeaeaeoaei/iie aeaeacu, aeaeoaeea i?e aeiia?oeiiao?eoa o aeaoae (eeeieei - yoi?aaeeiioeeeaeiua enneaaeiaaiey). - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.23 - eo/aaay aeeaaiinoeea, eo/aaay oa?aiey. - Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei. A.A. Aiaiiieueoea, Eeaa, 1998. Ia iniiaaiee eiiieaeniiai eeeieei - yoi?aaeeiioeeeaeiiai ianeaaeiaaiey 325 aeaoae n iao?ioe/aneie e niaoaiiie oi?iaie aeiia?oeiiao?eoa eco/aiu iniaaiiinoe no?oeoo?ii - ooieoeeiiaeueiiai ninoiyiey ia/aie, iiaeaeaeoaei/iie aeaeacu, aeaeoaeea, ninoiyiea ai?iiiaeueiiai aano?ieioanoeiaeueiiai noaoona a i?ioeanna iaoiaaiaoe/aneie oa?aiee. Ia iniiaa iiiaioaeoi?iiai ei??aeyoeeiiiiai aiaeeca auyaeaia acaeiinaycue ia?ooaiee ninoiyiey i?aaiia ieuaaa?aiey n oyaeanoueth oa/aiey aeiia?oeiiao?eoa, yoaiii aetheiei?oeeieaeiie e oeeoinoaoe/aneie oa?aiee, aa?eaioii ai?iiii/oanoaeoaeueiinoe, yooaeoii ea/aiey. Ii?aaeaeaiu ?aiiea ia?ea?u aiciiaeiuo ineiaeiaiee e iiai/iiai aeaenoaey aetheiei?oeeieaeia e oeeoinoaoeeia. Aeaii iainiiaaiea yoaiiiai enneaaeiaaiey aieueiuo n iiiiuueth ?ac?aaioaiiiai eiiieaena yoi?aaeeiioeeeaeiuo iaoiaeia, aeieacaia iaiaoiaeeiinoue ea/aaii - i?ioeeaeoe/aneeo ia?ii?eyoee aeaaea ia oiia eeeieei - eaai?aoi?iie ?aiennee. Onoaiiaeaii, /oi i?eiaiaiea aeeaaiinoe/aneiai aeai?eoia, iniiaaiiiai ia eniieueciaaiee ?aaeeieiioiieiae/aneiai aiaeeca, aeeiaie/aneie noeeioea?aoee, aeiiiea?ioeoiiao?ee iicaieyao oiaiueoeoue iauai enneaaeiaaiee, nieceoue eo/aaoth iaa?oceo ia i?aaieci ?aaaiea, a oaeaea iioeiece?iaaoue e eiaeeaeaeoaeece?iaaoue ea/aiea aeaoae, aieueiuo aeiia?oeiiao?eoii. Eeth/aaua neiaa: aeiia?oeiiao?eo o aeaoae, ia/aiue, iiaeaeaeoaei/iay aeaeaca, aeaeoaeie, aano?ieioanoeiaeueiua ai?iiiu, iaoiaaiaoe/aneay oa?aiey, yoi?aaeeiioeeeaeiua iaoiaeu enneaaeiaaiey, yooaeoeaiinoue ea/aiey. SUMMARY Tanasichuk - Gazhieva N.V. Integral characteristics of the state of the liver, pancreas, stomach in glomerulonephritis in children (clinical and echoradionuclide studies). - Manuscript. Thesis for a doctor’s of Medical Sciences degree by speciality 14.01.23 - radiation diagnosis, radiotherapy. A.A. Bogomolets National Medical University, Kyiv, 1998. The features of the structural and functional state of the liver, pancreas , stomach, gastrointestinal hormonal status in the dynamics of pathogenetic therapy have been stadied on the basis of a complex echoradionuclide examination of 325 children with nephrotic and mixed forms of glomerulonephritis. An interconnection between changes in the state of the digestive system and the severity of glomerulonephritis, the stage of glucocorticoid and cytostatic therapy, the variety of hormone sensibility and therapeutic effects have been determined using a multifactorial correlative analysis. Early markers of possible complications and side - effects of glucocorticoids and cytostatics have been found. A stage - by - stage study of patients by means of the developed complex of echoradionuclide methods has been grounded. The need for therapeutic and preventive measures even against the background in clinic and laboratory remission has been proved. The application of a diagnostic algorythm based on the use of radioimmunologic analysis, dynamic scintigraphy, echography, doppler flowmetry has been determined in order to improve and individualize the treatment of children with glomerulonephritis, to decrease the scope of studies, to lower the radial load on the child’s organism. Key words: glomerulonephritis in children, liver, pancreas, stomach, gastrointestinal hormones, pathogenetic therapy, echoradionuclide methods of study, treatment efficiency. 7 Oaaeeoey oa?ai?? aeiia?oeiiao?eoo o ae?oae. Ae?aaiinoe/iee aeai?eoi ia aoaiao iaoiaaiaoe/ii? I aoai II aoai oa?ai?y Ei?aaoth/a oeaeiy /a?ac 3 Eiio?ieue oeaeiy /a?ac 3 Eiio?ieue oa?ai?y Ei?aaoth/a oeaeiy /a?ac 3 Eiio?ieue oa?ai?y Ei?aaoth/a Ii?ia ? Ci?ie iaia? Ci?i ? Ci?ie aoaeaaiae?a ?aaeei, iaiaaeaiiy Noai?ee oa?/iaee Ci?i iaia? Ci?ie ? oeaeiy /a?ac 3 Eiio?ieue o?eineia ?ia?a?oi? e?iaca, ai?eaca, (??A), O?einei oeaeiy /a?ac 3 Eiio?ieue eiei?aeii ANA c On- oeaeiy /a?ac 3 Eiio?ieue oeaeiy /a?ac 3 Eiio?ieue i?aeaeuai? N-iaioeae ?inoe?i, neii?y o?a?iaano?i- ?I-iao??y, Ciiaeoaaiiy, oeaeiy /a?ac 3 Eiio?ieue iaceaea AANA c On iaia? Ci?i ? Ci?ie iaia? Ci?i e?iaiieeio Ci?ie caeice Aoia?ao?y iiaeoeoieiai? ia/?iee iea?iaoia?ao?y i Aei Ii?ia Cieaeaiiy i?aeaeuaiiy Ii?ia aai Cieaeaiiy Ii?ia I?aeaeuaiiy Aetheaaii Aano?ei Oie?eae?oeei aeaeaiiy aeine? Oeueo?acaoeiaa ?aae?i?ioiieia?/iee aiae?c

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