AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOOo EA?Ae?IEIA??

?i. aeaae. I.Ae. NO?AAEANEA

?AIAOAIEI A?eai??e Aiaoie?eiae/

OAeE 616.72-002:622

AeAAAIA?AOEAII-CAIAEUeI?

CAOAI?THAAIIss NOAEIA?A O OAOOA??A (?ICIIANTHAeAEAI?NOUe, INIAEEAINO?

IA?AA?AO, Ae?AAIINOEEA, IEOAIIss

IAOIAAIACO, E?EOAAIIss)

14.01.12 – ?aaiaoieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I.Ai?ueeiai IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, i?ioani? Neiy/aiei Ieaa Aieiaeeie?iae/,
Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I. Ai?ueeiai IIC
Oe?a?ie, caa?aeoaa/ eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Na?ioeeoeueeee Aiaoie?e Noai?neaaiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey IIC Oe?a?ie
(i. Ee?a), caa?aeoaa/ eaoaae?e aini?oaeueii? oa?ai?? ?2.

aeieoi? iaaee/ieo iaoe, i?ioani? Oaaae Ieeiea ?aaiiae/, Oa?iii?euenueea
iaaee/ia aeaaeai?y ?i. ?.ss. Ai?aa/aanueeiai IIC Oe?a?ie, caa?aeoaa/
eaoaae?e oaeoeueoaonueei? oa?ai??.

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Aa?aneiaiei Na?a?e
?aaiiae/, Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo o?aaiaoieia?? oa
i?oiiaae?? IIC Oe?a?ie (i. Ee?a), canooiiee aee?aeoi?a ii ee?i?oe?.

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC
Oe?a?ie, eaoaae?a aini?oaeueii? oa?ai?? ?2.

Caoeno a?aeaoaeaoueny 18 o?aaiy 1999 ?. i 10 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01 i?e ?inoeooo? ea?ae?ieia??
?i. aeaae. I.Ae. No?aaeanea AII Oe?a?ie (252151, i.
Ee?a, aoe. Ia?iaeiiai iiie/aiiy, 5).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae. No?aaeanea AII Oe?a?ie (252151, i. Ee?a,
aoe. Ia?iaeiiai iiie/aiiy, 5).

Aaoi?aoa?ao ?ic?neaiee 17 ea?oiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Aeaye N.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca inoaii? ?iee anthaee niinoa??aa?oueny ??no
/enaeueiino? ethaeae ?c aeaaaia?aoeaii-caiaeueieie caoai?thaaiiyie
iii?ii-?ooiaiai aia?aoo (I?A) [Aiiniaa E.I. oa ?io., 1992; Aaiaea ?.I.,
1995; Ianiiiaa A.I. oa ?io., 1998]. Aeooaeuei?noue ai?ioueae c oe??th
iaoieia??th aecia/a?oueny o?aaeaiiyi in?a i?aoeacaeaoiiai a?eo, ui
i?ecaiaeeoue aei aaeeeeo iaoa??aeueieo cao?ao o ca’yceo c o?eaaeith
oei/aniaith iai?aoeacaeaoi?noth oa aenieith ?iaae?aeecaoe??th
[Oa?eiaaiei I.I. oa ?io., 1995].

?aaiaoe/i? oai?iae a Oe?a?i? ca ??aiai ?iciianthaeaeaiino? caeiathoue
o?ao? i?noea (6 600 ia 100 oen. ianaeaiiy) [Eiaaeaiei A.I. oa ?io.,
1994, 1997]. Ia aeayeeo ae?iaieoeoaao, aea aeei?enoiao?oueny aaaeea
o?ce/ia i?aoey, oei/aniaa iai?aoeacaeaoi?noue o ?acoeueoao? noaeiaiai?
iaoieia?? nyaa? i?eaeecii 100 aeiaaee?a ia 100 i?aoethth/eo [Eoiae??a
TH.?. oa ?io., 1990; Ianiiiaa A.I., Oieii??aa I.I., 1991]. O ?icaeiooeo
e?a?iao aiane?aeie aeaaaia?aoeaii-caiaeueieo caoai?thaaiue eieiiioi?iiai
aia?aoo ui??/i? aeiiii?/i? ao?aoe neeaaeathoue aeecueei 1% caaaeueiiai
iaoe?iiaeueiiai i?iaeoeoo. Caoai?thaai?noue ia oai?iae noaeia?a na?aae
i?aaenoaaiee?a ie?aieo i?iieneiaeo i?aei?e?inoa cia/ii ia?aaeuo?
iieacieee a iiioeyoe?? [Aei?ioaiei TH.A. oa ?io., 1991; Aeceaoiiaa I.I.,
1994; ?oaei?a I.N., 1995; Neiy/aiei I.A. oa ?io., 1997].

Oiiae i?aoe? o aoa?eueieo oaooao oa?aeoa?ecothoueny iayai?noth eiiieaeno
iani?eyoeeaeo oaeoi??a ae?iaie/iai na?aaeiaeua, ye? nooo?ai aieeaathoue
ia noai caei?ia’y a??iee?a [Eanoeia Ae.I., 1995; I?iyeei I.?., 1995;
Noe/einueea I.A., Aeioeaiei O.I., 1995; Aaeooeeia A.I. oa ?io., 1996].
Aeecueei 70 % i/enieo aeai?a ciaoiaeeoueny ca?ac o cii? neeaaeieo
a??ie/iaaieia?/ieo oiia [Eiaaoeue A.I. oa ?io., 1992; Iooee?ia I.I.,
Iaea?aanueea A.A., 1995]. Caeeoa?oueny aenieith /anoea ?o/ii? i?aoe? o
oaoiieia?? ae?iee aoa?eey, yea ?icaeyaea?oueny ye oyaeea ? iai?oaeaia
[I?iyeei I.?., Oeoeye ?.A., 1994], a iaoai?caoe?y iniiaieo ae?iaie/eo
i?ioean?a ia caaaeaee ni?ey? cieaeaiith oyaeeino? i?aoe? o ca’yceo c
eiai ?ioaineo?eaoe??th [Nieaeae ?.?. oa ?io., 1998]. O i?ioean?
o?oaeiai? ae?yeueiino? ia i?aai?ci oaooa??a ae?? noeoii?noue ae?iaie/eo
oaeoi??a, ye? iia’ycai? c i?ioeanaie aoaeaaeaeiaooeo – aoa?eueiee ?
ii?iaeiee iee, ooi, a?a?aoe?y, aaciiiae?ai? i?iaeoeoe aeaooo,
iiaa?oiaai-aeoeai? ?a/iaeie (IA?), i?aeaeuaia oaiia?aoo?a ? aeniea
a?aeiinia aieia?noue iia?o?y, iaaeeeoie aa?iiao?e/iiai oeneo [Caieyeiaa
E.O., Iaooeueei N.I., 1995; I?iyeei I.?., 1995; Ia?aaea??e A.N., 1995].
Aei iniiaieo oaeoi??a ?eceeo caoai?thaaiue noaeia?a o ?ia?oiee?a
aoa?eueieo oaoo iaeaaeaoue i?e?iee?iaoe/i? aieeae, noaoe/i?,
noaoeei-aeeiai?/i? oa ?io? aeaee iai?oae eieiiioi?iiai aia?aoo o
ii?aeiaii? c i?e?io?aaiaoecaoe??th noaeia?a, iiiioiii? iaeiiiai?oi?
?ooe, ciooaia iieiaeaiiy o?ea, oene, oa?oy, eiacaiiy ca’yceiaiai aia?aoo
[Eiaaoeue A.I. oa ?io., 1992; Nieaeae ?.?. oa ?io., 1998]. ?ioaa?aeueiee
eiao?oe??io caoai?thaaiino? c oei/aniaith ao?aoith i?aoeacaeaoiino? eeoa
ca 7 ?ie?a ca?eueoeany a?eueo, i?ae ao?e/? [Neiy/aiei I.A. oa ?io.,
1997], ui i?yii ei?aeth? c aeeaeiith ?ic?iaie ? eooii iaoeeo aoa?eueieo
oa??a [Ieoaeeiaa O.A., Aieueae?i A.A., 1995]. Ia aeaeue, iiee a?aenooi?
aeine?aeaeaiiy, ye? noinothoueny aea/aiiy ?iciianthaeaeaiino?,
ee?i?/iiai ia?aa?ao ? iaoiaaiaco caoai?thaaiue I?A na?aae oaooa??a
??cieo i?ioan?eieo a?oi caeaaeii a?ae a??ie/iaaieia?/ieo oaeoi??a oaoo.
Ie??i oiai, ? iaaaeueia iio?aaa oaeineiiaeaiiy a?aeiii? oa?ai?? ?
?ic?iaee i?eioeeiiai iiaeo iaoiae?a e?eoaaiiy oaei? eaoaai??? oai?eo
[Aecye A.A., Eia?iia N.A., 1995; Iaeei ?.I., Aieiaa/ ?.TH., 1998;
Aaaei?ia E.ss., Aaioea O.I., 1997; Iaoyaeaiei A.C., Iaeue/aanueea O.E.,
1998].

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue a?aeiia?aeii c iniiaiei ieaiii IAe? Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ? ? o?aaiaioii eiieo?nieo
eiiieaenieo oai IIC Oe?a?ie “Iaa?oiooaaoe, ?ic?iaeoe ? ai?iaaaeeoe
iaaee/io oaoiieia?th ae?aaiinoeee e e?eoaaiiy aeaaaia?aoeaieo,
caiaeueieo ? iaoaaie?/ieo caoai?thaaiue noaeia?a o a??iee?a aoa?eueieo
oaoo” (? aea?ae?a?no?aoe?? 019008145), “?ic?iaea ? ai?iaaaeaeaiiy
caoiae?a uiaei ?aiiuei? ae?aaiinoeee oa aoaeoeaiiai e?eoaaiiy
caoai?thaaiue noaeia?a o ?ia?oiee?a aoa?eueii? i?iieneiaino?” (?
aea?ae?a?no?aoe?? 0195V023598) oa “Aea/eoe noai aeeiai?/iiai
iiaa?oiaaiai iaoyao a?ieia?/ieo ??aeei o caei?iaeo ethaeae oa oai?eo c
??ciiiai?oieie caoai?thaaiiyie oa?aiaaoe/iiai i?io?eth” (?
aea?ae?a?no?aoe?? 0197V002098). Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie,
ieaiaie, oaiaie. ?iaioa aeeiioaaeanue a?aeiia?aeii c iniiaiei ieaiii
IAe? Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ? ? o?aaiaioii
eiieo?nieo eiiieaenieo oai IIC Oe?a?ie “Iaa?oiooaaoe, ?ic?iaeoe ?
ai?iaaaeeoe iaaee/io oaoiieia?th ae?aaiinoeee e e?eoaaiiy
aeaaaia?aoeaieo, caiaeueieo ? iaoaaie?/ieo caoai?thaaiue noaeia?a o
a??iee?a aoa?eueieo oaoo” (? aea?ae?a?no?aoe?? 019008145), “?ic?iaea ?
ai?iaaaeaeaiiy caoiae?a uiaei ?aiiuei? ae?aaiinoeee oa aoaeoeaiiai
e?eoaaiiy caoai?thaaiue noaeia?a o ?ia?oiee?a aoa?eueii? i?iieneiaino?”
(? aea?ae?a?no?aoe?? 0195V023598) oa “Aea/eoe noai aeeiai?/iiai
iiaa?oiaaiai iaoyao a?ieia?/ieo ??aeei o caei?iaeo ethaeae oa oai?eo c
??ciiiai?oieie caoai?thaaiiyie oa?aiaaoe/iiai i?io?eth” (?
aea?ae?a?no?aoe?? 0197V002098).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa ?iaioe – aecia/eoe caeaaei?noue
?iciianthaeaeaiiy aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a a?ae
a??ie/iaaieia?/ieo oiia i?aoe? oaooa??a, i?aeaeueoe ye?noue ae?aaiinoeee
e e?eoaaiiy inoaia?o?ico (IA), oai?iae ?aeoa?a (O?), iiaeaa?e/iiai
a?o?eoo (IA), ?aaiaoi?aeiiai a?o?eoo (?A) ? oai?iae A?oo???aa (OA) o
a??iee?a aoa?eueieo oaoo ??cieo i?ioan?eieo a?oi. O ca’yceo c oeei aoei
iinoaaeaii oae? caaea/?:

1. I?iaanoe ai?aeai?ieia?/i? aeine?aeaeaiiy oaoo c ??cieie
a??ie/iaaieia?/ieie oaeoi?aie uiaei aeyaeaiiy aeaaaia?aoeaii-caiaeueieo
oai?ia I?A o ?ia?oiee?a ??cieo i?ioan?eieo a?oi, ioe?ieoe ?ioaa?aeueiee
eiao?oe??io caoai?thaaiino? c oei/aniaith ao?aoith i?aoeacaeaoiino?.

2. Aecia/eoe cia/aiiy aaiaoe/ieo oaeoi??a noeeueiino? aei
aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o
oaooa??a-aoa?eueiee?a.

3. Ioe?ieoe ee?i?ei-?aioaaiieia?/iee ia?aa?a ie?aieo caoai?thaaiue
eieiiioi?iiai aia?aoo o i?io?aeiee?a (I?), a??iee?a i/eniiai aeaith
(A?IA), i?aecaiieo a??iee?a (IA?), e??ieeueiee?a (E?), iaoei?no?a
a??ie/iae?iieo iaoei (IAAI), i?aecaiieo aeaeo?inethna??a (IAN),
i?ae?eaiee?a (I?ae), a??ie/eo iaeno??a (AI) a caeaaeiino? a?ae
a??ie/iaaieia?/ieo oiia ?o i?aoe?, a oaeiae o ?ia?oiee?a iaoaooa?nueeeo
i?ioan?e.

4. Aeine?aeeoe noai e?i?aeiiai, io?eiiaiai oa eaeueoe??aiai iai?i?a,
ai?iiiaeueiiai noaoono, iieaciee?a ia?aeeniiai ieeneaiiy e?i?ae?a (IIE)
oa aioeieneaeaioieo nenoai o caei?iaeo oaooa??a iniiaieo oa aeiiii?aeieo
i?ioan?e, o /ieia?e?a – iaoaooa??a ? oai?eo ia aeaaaia?aoeaii-caiaeuei?
caoai?thaaiiy noaeia?a.

5. Aea/eoe a e?ia? caei?iaeo ? oai?eo oaooa??a eiioeaio?aoe?? ?2 —
i?e?iaeiaoe?io (?2-IA), oeeee?/ieo ioeeaioeae?a (OeI), i?inoaaeaiaeei?a
(IA) A2 ? F2?, a oaeiae ??aaiue i?icaiaeueieo e?ciniiieo oa?iaio?a oa
aaeaaceaiiai aenieiiieaeoey?iiai a?eea a neiia?aeuei?e ??aeei? (N?) ca
i?ioan?eiiai IA.

6. Aeyaeoe ci?ie ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a ? iaeo?io?e?a,
iai?oaeai?noue aoii?aeueiiai ?ioi?oaoo i?e IA oa a?o?eoao o oaooa??a
caeaaeii a?ae a??ie/iaaieia?/ieo oiia ?o i?aoe?.

7. Aeeiiaoe aeeiai?/io i?aeoacio oaic?iiao??th ne?iaaoee e?ia? oa na/?
i?e ??cieo caoai?thaaiiyo noaeia?a o oaooa??a, aecia/eoe ae?aaiinoe/io
cia/ou?noue aeine?aeaeaiiy iiaa?oiaaiai iaoyao (II) a?ieia?/ieo ??aeei
oa eiai ?ieue aeey ioe?iee aoaeoeaiino? ca e?eoaaeueieie caoiaeaie, ui
i?iaiaeyoueny.

8. Ioe?ieoe aoaeoeai?noue caaaeueii-a?aeiieo ?aaa?e?oaoe?eieo caoiae?a
i?e ie?aieo aeaaaia?aoeaii-caiaeueieo caoai?thaaiiyo I?A o oaooa??a
iniiaieo oa aeiiii?aeieo i?ioan?e ? iaa?oiooaaoe aeioe?euei?noue
canoinoaaiiy iiaeo iaoiae?a e?eoaaiiy c a?aooaaiiyi iniaeeainoae
iaoiaaiaco caoai?thaaiue o oaeeo oai?eo.

9. ?ic?iaeoe ? ai?iaaaeeoe oaoiieia?th iaaeeeaiaioicii? oa?ai?? IA oa
a?o?eo?a o a??iee?a c aeei?enoaiiyi eiiieaeniooai?thth/eo oa
o?eeiii?iae?coth/eo i?aia?ao?a, oiiae?ii?ioaeoi??a, aiae?iaai?a,
aioeieneaeaio?a oa iie?oa?iaioieo cania?a.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aea/aii /anoioo
iin?enoaa aioeaai?a nenoaie HLA (ethaenueeee eaeeioeeoa?iee aioeaai) oa
a?eo?ioeeoa?ieo aioeaai?a o oaooa??a c iaoieia??th I?A. Aia?oa ioe?iaii
noai e?i?aeiiai, io?eiiaiai oa eaeueoe??aiai iai?i?a, ai?iiiaeueiiai
noaoono, IIE ? aioeieneaeaioieo nenoai o a??iee?a iniiaieo ?
aeiiii?aeieo i?ioan?e, eio?? no?aaeaeathoue ia IA oa a?o?eoe. Aia?oa
aeyaeaii ci?ie OeI ? IA a e?ia? oai?eo c caoai?thaaiiyie eieiiioi?iiai
aia?aoo, a oaeiae ii?ooaiiy ooieoe?? ?ioiieiiiaoaioieo ee?oei caeaaeii
a?ae i?ioan?? ?ia?oiee?a oa a??ie/iaaieia?/ieo oaeoi??a oaoo. Aia?oa
onoaiiaeaii cia/aiiy ?2-IA oa i?ioecaiaeueieo e?ciniiieo oa?iaio?a o
aaiac? aoi?eiiiai ?aaeoeaiiai neiia?oo (?N) o oai?eo c i?ioan?eiei IA, a
oaeiae ii?ooaiiy e?iaiia?ao a a?oeeoey?ieo oeaieiao o iaoiaaiac? oeueiai
caoai?thaaiiy. Aia?oa i?iaaaeaii aeeiai?/io i?aeoacio oaic?iiao??th
ne?iaaoee e?ia?, na/? i?e oai?iaao noaeia?a o oaooa??a ? iaoaooa??a,
ioe?iaii ?ieue ii?ooaiue II a?ieia?/ieo ??aeei aeey ae?aaiinoeee
iaoieia?? I?A. Ca oaiith aeena?oaoe?? io?eiaii iaoaio ia aeiao?ae 24689
A a?ae 04.08.98, oa iaea?aeaii iiceoeaia ??oaiiy i?i aeaea/o iaoaioo ia
aeiao?ae (?a?no?aoe?eiee iiia? cayaee 97125773 a?ae 01.10.98).

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Onoaiiaeaii ?ioaa?aeuei?
eiao?oe??ioe caoai?thaaiino? ia IA, O?, IA, ?A oa OA c oei/aniaith
ao?aoith i?aoeacaeaoiino? oai?eo a??iee?a, ui aeicaieeei i?aeaeueoe
ye?noue aeeniaina?ecaoe?? ia aoa?eueieo oaooao. Aecia/aii
?ioi?iaoeai?noue ee?i?ei-?aioaaiieia?/ieo iieaciee?a ae?aaiinoeee
ie?aieo oai?ia noaeia?a o iaoaooa??a oa oaooa??a iniiaieo ? aeiiii?aeieo
i?ioan?e. ?ic?iaeaii iniaeeaino? ?aaa?e?oaoe?? oai?eo I?, A?IA, IA?, E?,
IAAI, IAN, I?ae, AI, eio?? i?aoeththoue a ??cieo a??ie/iaaieia?/ieo
oiiaao. Iniiai? ?acoeueoaoe iaea?aeaieo aeine?aeaeaiue ai?iaaaeaeaii a
i?aeoeeo 16 e?eoaaeueieo onoaiia Aeiiaoeueei?, Eoaainueei? oa
Iieoaanueei? iaeanoae (iaoiaee/iee iin?aiee “Aeine?aeaeaiiy noaeia?a”,
1992, iaoiaee/i? ?aeiiaiaeaoe??: “Inoaia?o?ic o oaooa??a
(?iciianthaeaeai?noue, iaoiaaiac, ae?aaiinoeea, e?eoaaiiy)”, 1994,
“Iaiaaeeeaiaioicia e?eoaaiiy oai?ia noaeia?a o ?ia?oiee?a i?iieneiaeo
i?aei?e?inoa”, 1994), oa a iaa/aeueiee i?ioean iaaee/ieo aoc?a
(iaa/aeueiee iaoiaee/iee iin?aiee “Iaoiaee aeine?aeaeaiiy noaeia?a”,
1995), ui a?aeaeca?eaeaii a a?aeiia?aeieo aeoao ai?iaaaeaeaiiy.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a a iaea?aeai? ?acoeueoaoe
iaoeiaeo aeine?aeaeaiue ? iniiaiei ? iieyaa? o i?iaaaeaii?
ai?aeai?ieia?/ieo aeine?aeaeaiue ia oaooao, ianoaaeaii? oa e?eoaaii?
oai?eo o ee?i?oe?, eiinoeueoaoe?yo e?ea??a o iie?ee?i?oe?, o aeeiiaii?
oeueo?acaoeiaiai oa ?aia?ao?/iiai iaoiae?a aeine?aeaeaiiy, aiae?c?
aeaieo a?io?i?/iiai, ?aae?i?cioiiiiai, ?ioiieia?/iiai, ?ioiioa?iaioiiai
oa a?io?ce/iiai iaoiae?a aea/aiiy a?ieia?/ieo ??aeei o caei?iaeo
/ieia?e?a oa ?ia?oiee?a ??cieo i?ioan?e. Caeiaoaa/ ?ic?iaea iaaee/io
oaoiieia?th ?aaa?e?oaoe?? oaooa??a c iaoieia??th noaeia?a, cai?iiiioaaa
? ai?iaaaeea o i?aeoeeo ioi?iie caei?ia’y iia? iaoiaee e?eoaaiiy oaeeo
oai?eo. Aaoi? naiino?eii i?ia?a noaoenoe/io ia?iaeo iaea?aeaieo
?acoeueoao?a. Aeena?oaioii ia aoei aeei?enoaii ?acoeueoaoe e ?aea?
ni?aaaoi??a ioae?eaoe?e.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe?eii?
?iaioe aeeeaaeaii ia I eiia?an? ?aaiaoieia?a Oe?a?ie (Oa?iii?eue, 1993),
ia Oe?a?inuee?e iaoeia?e eiioa?aioe?? “I?iiaiaaa ae?aaiinoeea oa
i?iiaiaaa oa?ai?y i?ioan?iiaeueieo ? nenoaiieo caoai?thaaiue”
(Aeiiaoeuee, 1993), iaoeia?e eiioa?aioe?? “No/ani? i?iaeaie ee?i?/ii?
aiaeie?eiieia?? “ (Oa?e?a, 1993), Oe?a?inuee?e eiioa?aioe?? “Aeooaeuei?
ieoaiiy aeiaaiaoeee oa ?ioiieia?? “ (Iieoaaa, 1994), Oe?a?inuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? i?iaeaie o?ce/iiai aeoiaaiiy
o aoc? “ (Aeiiaoeuee,1995), Oe?a?inuee?e eiioa?aioe?? c i?aeia?iaeiith
o/anoth “Aeooaeuei? ieoaiiy a?a??ie i?aoe?, i?ioiaoieia?? oa iaaee/iiai
caaacia/aiiy i?aoe?aiee?a i?iieneiaeo i?aei?e?inoa” (Aeiiaoeuee, 1995),
I c’?cae? Oe?a?inueeiai oiaa?enoaa e??ia?ieia?? ? e??iiaaeeoeeie”
(Oa?e?a, 1995), iaoeia?e eiioa?aioe?? “Aeooaeuei? ieoaiiy oai?aoe/ii? oa
ee?i?/ii? iaaeeoeeie ia no/aniiio ??ai? “ (Iieoaaa, 1996), eiioa?aioe??
?aaiaoieia?a Oe?a?ie “No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”
(Aeiiaoeuee, 1996), II Iaoe?iiaeueiiio eiia?an? ?aaiaoieia?a Oe?a?ie
(Ee?a, 1997), X ?a?iiaenueeiio neiiic?oi? ?aaiaoieia?a
(A?aeaiue,Aano??y, 1997), XIV c’?cae? oa?aiaao?a Oe?a?ie (Ee?a, 1998),
iaoeiai-i?aeoe/ieo eiioa?aioe?yo e?ea??a-oa?aiaao?a, ?aaiaoieia?a,
ii?oieia?a, a?a??i?no?a oa a/aieo Aeiiaano (Aeiiaoeuee, 1992-1998),
ni?eueiiio can?aeaii? eaoaae? i?iiaaeaaoeee aioo??oi?o oai?ia,
aini?oaeueii? oa?ai??, a?noieia??, ?ioiieia??, a?a??ie, i?ioan?eieo
caoai?thaaiue oa a?aeae?eo Oe?a?inueeiai iaoeiaiai oeaio?o oaoi?/ii?
aeieia?? (Aeiiaoeuee, 1999).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii iiiia?ao?th
“Aeine?aeaeaiiy noaeia?a” (9 naiino?eieo aeaa) oa 44 iaoeiaeo i?aoe?, a
oiio /ene? a aeo?iaeao “A?o?a ee?i?/ii? oa aenia?eiaioaeueii?
iaaeeoeeie” (5), “E?ea?nueea ni?aaa” (3), “Oe?a?inueeee ea?ae?ieia?/iee
aeo?iae” (2), “Iaaeeoeeia i?aoe? oa i?iieneiaa aeieia?y” (2),
“?aaiaoieia?y” (1), “A?niee a?a??ie oa ai?aeai?ieia?? “ (1), “Aaciaea
i?aoe? o i?iieneiaino? “ (1), “E?ee” (1), “Iaoieia?/ia o?c?ieia?y oa
aenia?eiaioaeueia oa?ai?y” (1), “Ee?i?/ia oa?iaeieia?y, o?c?ieia?y,
a?io?i?y” (1), “Oeiea ooiaeaiaioaeueii? iaaeeoeeie” (2), “I?oiiaae?y,
o?aaiaoieia?y, i?ioacoaaiiy” (1), ca??eao iaoeiaeo i?aoeue (6),
iaoa??aeao ? oacao iaoeiaeo oi?oi?a (16). Iaea?aeaii iaoaio ia aeiao?ae.

No?oeoo?a aeena?oaoe??. Aeena?oaoe?th aeeeaaeaii ia 359 noi??ieao
ae?oeiaaiiai oaenoo ? aiia neeaaea?oueny ?c anooio, 6 ?icae?e?a (a oiio
/ene? iaeyaeo e?oa?aoo?e, iaoa??ae?a oa iaoiae?a aeine?aeaeaiiy, 4
?icae?e?a aeanieo aeine?aeaeaiue), aeniiae?a, nieneo aeei?enoaieo
aeaea?ae, yeee i?noeoue 359 iaeiaioaaiue ? aeiaeaoeo. ?iaioa
?ethno?iaaia 114 oaaeeoeyie oa 69 ?enoieaie.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. I?iaaaeaii ianoaaeaiiy 1000 oaooa??a
ia 5 oaooao c ??cieie a??ie/iaaieia?/ieie oiiaaie. ?ic?iaeaii
niaoe?aeueio aieaoo, ui aeicaieeea iiia?aaeiuei ae?aaiinooaaoe
aeaaaia?aoeaii-caiaeuei? caoai?thaaiiy noaeia?a o a??iee?a. Iaoieia?th
noaeia?a cai?aeic?aii o 388 (38,8%) c ieo. Na?aae ianoaaeaieo oaooa??a
30,6% aoee I?, 16,2% – A?IA, 9,7% – IA?, 7,2% – E?, 15,7% – IAN, 10,7% –
AI, 9,9% – IAAI. sseui a a?oi? oaooa??a c oai?iaaie I?A ni?aa?aeiioaiiy
ca i?ioan?yie noaiiaeoue: I? : AI : IAN : A?IA : IAAI : IA? : E? = 12 :
4 : 3 : 2 : 2 : 2 : 1, oi a ?ioeo ?ia?oiee?a – I?: AI: IAN: A?IA: IAAI:
IA?: E? = 2 : 1 : 2 : 2 : 1 : 1 : 1. Ia?o? iciaee caoai?thaaiue noaeia?a
o IAN, I? ? AI c’yaeeeny /a?ac 6-7 ?ie?a i?ney ii/aoeo ?iaioe a oaoo?, o
oie /an ye o E?, IAAI ? IA? noaae ?iaioe a oaoo? ia ii/aoie
caoai?thaaiiy noaiiaea 14-16 ?ie?a.

On?o oaooa??a ?c aeaaaia?aoeaii-caiaeueieie caoai?thaaiiyie noaeia?a ie
oiiaii iiae?eeee ia 2 a?oie: aei 1-? (iniiaii?) caianai? i?aaenoaaieee
iniiaieo oaooa?nueeeo i?ioan?e (IOI) (I?, A?IA, E?, IA?, IAAI), a aei
2-? (eiio?ieueii?) – aeiiii?aeieo (IAN, AI, iaoai?ee, I?ae).

IA aiane?aeie i?ioan?eii? ae?yeueiino? oaooa??a aeyaeaii o 31,9%
ianoaaeaieo a??iee?a ? o 82,0% a?ae e?eueeino? in?a c iaoieia??th
eieiiioi?iiai aia?aoo, IA – o 3,9% ? 10,1%, O? – o 2,4% ? 6,2%, ?A – o
0,4% ? 1,0%, OA – o 0,2% ? 0,5% a?aeiia?aeii. Ia /anoeo A?IA ? I?
i?eiaaea? iaeaea iieiaeia a?ae on?o aeiaaee?a IA (a?aeiia?aeii 25,9%
aoee A?IA ? 20,4% – I?). O oie aea /an o oaooa??a aeiiii?aeieo i?ioan?e
IA niinoa??aa?oueny iaeaea aaea?/? ??aeoa ii??aiyii c iniiaiith a?oiith.
O IA? cia/ii /ano?oa cono??/aeeny caiaeuei? caoai?thaaiiy noaeia?a.
sseui na?aae on?o ianoaaeaieo a??iee?a IA? aoei 9,7% in?a, oi na?aae
oai?eo ia IA – o?eueee 2,7%.

A iaea?eueo ?aii? no?iee a?ae ii/aoeo o?oaeiai? ae?yeueiino? a oaoo?
oi?iothoueny aai iiiiie?aia?o?ic aac neiia?oo, aai iie?inoaia?o?ic, aea
aaea c ?N. Ui noino?oueny ?A ? O?, oi aiie ?icaeaaeenue ua ?ai?oa a?ae
ii/aoeo ae?iaie/i? ae?yeueiino?, noaae ?iaioe i?e oeueiio ia ii/aoie
caoai?thaaiiy neeaaeaa 4,7±0,8 ? 4,9±0,5 ?ie?a a?aeiia?aeii.

Aeey I? ? IAAI a?eueoith i??ith oa?aeoa?iee iiiiie?aia?o?ic aac
neiia?oo, aeey A?IA ? IA? – iiiiie?aia?o?ic c neiia?oii, aeey IAN –
iie?inoaia?o?ic aac neiia?oo, aeey AI – iie?inoaia?o?ic ?c neiia?oii. IA
? O? a?eueoa oa?aeoa?i? aeey I?, o oie /an ye ?A, a iniiaiiio,
i?eoaiaiia IAN, IAAI ? AI. OA iaeiaeiai /anoi cono??/a?oueny o IAAI ?
AI.

*anoeio oai?eo aoei a?ae?a?aii aeey aeaoaeueiiai ianoaaeaiiy a oiiaao
ee?i?ee. Noi?iiaaia a?oia oaooa??a, ye? no?aaeaeathoue ia IA (147 in?a),
?A (57 in?a), O? (123 iniae), OA (42 iniae), IA (106 in?a). On? aiie
?iciiae?eai? ia a?oio a??iee?a iniiaieo i?ioan?e ? a?oio aeiiii?aeieo
i?ioan?e. Ua iaeio a?oio ii??aiyiiy neeaee 200 /ieia?e?a ?c
caiaeueii-aeaaaia?aoeaieie caoai?thaaiiyie noaeia?a, aea i?aaenoaaiee?a
aaeocae iaoeiiaoaeoaaiiy, iaoaeo?a?? oa eienio?i??. On? oe? iaoe??ioe
aoee ?ia?oieeaie ? aoee a?aeiia?aeieie a?oiai oai?eo oaooa??a ca a?eii.

Eiiieaen ianoaaeaiiy oai?eo oaooa??a aoei iiaoaeiaaii ia ee?i?/iiio,
eaai?aoi?iiio, ?aioaaiieia?/iiio, ?aae?i?cioiiiiio (noeeio?a?ao?y),
oeueo?acaoeiaiio (niiia?ao?y) oa ?ino?oiaioaeueiiio (?aia?ao?y) iaoiaeao
aeine?aeaeaiiy noaeia?a.

A ne?iaaooe? e?ia? aeine?aeaeaii eiioeaio?aoe?? caaaeueiiai a?eeo,
aeueaoi?i?a, o?aeoe?e aeiaoe?i?a ? ?ioiiaeiaoe?i?a (?A), oee?eoethth/eo
?ioiieo eiiieaen?a (Oe?E), ?2-IA, na/iai? eeneioe (NE), ieneio?eiieo
(II), enaioeiieneaeace (EI), oieanoa?eio (ON), ?-ON, o?eae?oea?eae?a
(OA), e?iii?ioa?ae?a aeniei? aonoeie (EIAA), e?iii?ioa?ae?a iecueei?
aonoeie (EIIA), e?iii?ioa?ae?a aeoaea iecueei? aonoeie (EIAeIA), IA-A2,
IA-F2?, i?inoaoeeee?io, o?iiaienaio, eaeueoe?th (Na) ? ?ii?ciaaiiai
eaeueoe?th (Na++), eoaeii? oinoaoace, oinoi?o, ai?iii?a (ia?aoe?ai?aeiee
ai?iii (IOA), eaeueoeeoii?i (EO), eaeueoeeo?eie (EO?), ei?oecie,
oe?aio?iiiee ai?iii, o?eeiaeoe?iiei, oe?ienei, oanoinoa?ii (O),
ano?aae?ie (A), i?iaanoa?ii (I), oie?o?ii?i (O), etho?ii?i (E)).
Aeei?enoai? aia?aoe “Eiia-I?ia?an-Iethn”, “Eiia-Niaoeeo?e”, “I?e?ie?o”,
“Oaeaia-I?ioean-24”, “Aeaeanei”, “Aaiia-12”, “Ae?A-Iethn” o??i
O?ieyiae??, O?aioe??, ssiii??, Oe?a?ie, Oaaeoea???, ?in??, iaai?e aeey
?aae?i?ioiieo aeine?aeaeaiue ae?iaieoeoaa A?ei?on?, NOA (“Clinical
Assays”), Oai?ueie (“Institute of Isotopes”), O?aioe??
(“Cis-International”) Oaaeoea??? (“Buhlman”) oa Oaaoe?? (“Phadebas”), a
aeey ?ioiioa?iaioieo – ?in?? oa Oaaeoea???.

Ia?aeaeueii c ai?noii IA a ieaci? e?ia? ?aae?i?ioiiei iaoiaeii aecia/aee
??aaiue oeeee?/iiai aaeaiiceiiiiioinoaoo (oeAIO) oa oeeee?/iiai
aoaieiiiiioinoaoo (oeAIO). Aeei?enoai? iaai?e o??ie “Amersham” (Aaeeea
A?eoai?y).

Oi?o?eiaaieie iaoiaeaie c aeei?enoaiiyi oethi?eiao??? oa
niaeo?ioioiiao??? aecia/aee eiioeaio?aoe?th oaeoi??a IIE ?
aioeieneaeaioieo nenoai – ae??iiaeo eii’thaao?a (AeE), iaeiiiaiai
aeeaeueaeaa?aeo (IAe), noia?ieneaeaeeniooace (NIAe),
aeooao?iiia?ieneaeace, aeueoa-oieioa?ieo (OO).

Na?aae ?ioiieia?/ieo iieaciee?a ioe?ithaaee ai?no O-e?ioioeeo?a oa
A-e?ioioeeo?a o e?ia?, ?o noaiiioeyoe?e, ooieoe?iiaeueio aeoeai?noue
ee?oei o ?aaeoe?? aeanoii? o?ainoi?iaoe?? e?ioioeeo?a (?AOE) ia
o?oiaaiaaethoei?i (OAA) ? eiieaiaaae?i-A (Eii), eiioeaio?aoe?th ?A G, A,
M, ??aaiue aioeo?e aei iaoeaii? AeIE (a-iAeIE), aioeo?e aei
aeaiaoo?iaaii? AeIE (a-aeAeIE) oa aioeo?e aei AAA (a-AAA),
i?ioeneiia?aeueieo aioeo?e (INA) ? i?ioeo?yuiaeo aioeo?e (IOA) a
?aaeoe?? ianeaii? aaiaaethoeiaoe??.

Aeey aeyaeaiiy aioeaai?a a?noinoi?noino? aeei?enoiaoaaee eiia?oe?ei?
ne?iaaoee “Behring” (I?ia//eia), “Biotest” (I?ia//eia), “Pel-Freez”
(NOA), “Hoechst” (I?ia//eia) oa Naieo-Iaoa?ao?cueeiai IAe? aaiaoieia??
(?in?y).

Aea/aiiy aeeiai?/iiai II ne?iaaoee e?ia?, na/? oa neiia?th aeeiiaii
iaoiaeii iaeneiaeueiiai oeneo a aoeueaaooe?, ui ?aae?ciaaiee a
eiii’thoa?ieo oaic?iiao?ao I?O-1 ? I?O-2 (LAUDA, I?ia//eia). Aeey
?ioaa?aeueii? ioe?iee II a?ieia?/ieo ??aeei ia oaic?ia?aiao aecia/aee
oi/ee, ye? a?aeiia?aeaee t=0,01n (II1) ? t=1n (II2), a oaeiae
??aiiaaaiiiio (noaoe/iiio) II (II3) i?e t??. Ie??i oiai, i?ae?aoiaoaaee
eoo iaoeeo e?eai? (EIE) a eii?aeeiaoao II t-1/2.

O ?ac? i?aeic?e ia ?aaeoeaiee oeai?ae?eiee o?iaai?oaeueiee a?o?eo o an?o
oaooa??a i?iaaaeaii aaeoa??ieia?/ia ianoaaeaiiy cieao c o?ao?e
ia?aaei?oo?iaiai nieo ia oeai?ae??. O a?eueoino? oaeeo oai?eo a e?ia?
aecia/aee ??aaiue i?ioeoeai?ae?eieo aioeo?e oa iayai?noue oeai?ae?eiiai
aioeaaio.

Iaie i?iaiae?ciaaii ?acoeueoaoe ?aaa?e?oaoe?? 470 oaooa??a, eio??
no?aaeaeathoue ia aeaaaia?aoeaii-caiaeuei? caoai?thaaiiy I?A. IA aoa
iayaiee o 197 oai?eo (?c ieo o 76 eiinoaoiaaii iie?inoaia?o?ic, a o 105
– iciaee aoi?eiiiai ?N), IA – o 134 (o?ii?/iee aa??aio aeyaeaii o 62
niinoa?aaeaiiyo, ?ioa?i?ooth/ee – o 72), O? – o 61, ?A – o 43 (a on?o
aeiaaeeao aeyaeaii iie?a?o?eo, o 29 – na?iiiceoeaiee), o 35 – OA
(oeaio?aeueia, ?eciiae?/ia oa ia?eoa?e/ia oi?ie).

Oai?eo oiiaii iiae?eeee ia 3 a?oie: aei 1-i? aeeth/eee 304 iniae, eio??
iaea?aeoaaee o?eueee iaaeeeaiaioici? caniae, aei 2-i? (91 oai?ee)
oa?eoee ?ia?oieee, yeei aeiaeaoeiai i?aeeeth/aee o?ce/i? i?aoi?iiaai?
oaeoi?e, aei 3-i? (75 oai?eo) – eio?ei, ie??i e?ea?nueeiai oa o?ce/iiai
e?eoaaiiy i?ecia/aee aaeueiai- oa iaei?aeioa?ai?th a naiaoi?ii-eo?i?oieo
oiiaao.

I?ae?aoiaoaaee ?ioaa?aeueiee eiao?oe??io caoai?thaaiiino? c oei/aniaith
ao?aoith i?aoeacaeaoiino?, ?ioaineaiee iieaciee ?iciianthaeaeaiino?
oai?ia noaeia?a, ?ioaa?aeueiee nooi?iue ci?i o oaooa??a iai?i?a ?a/iaei,
ai?iiiaeueiiai oa ?ioiiiai noaoon?a. Aeey c?noaaeaiiy c eiio?ieueieie
cia/aiiyie an? iieacieee aeine?aeaeoaaee o 30 i?aeoe/ii caei?iaeo
/ieia?e?a iaoaooa??a ? 30 i?aeoe/ii caei?iaeo a??iee?a, ye? iiai?noth
a?aeiia?aeaee a?oiai oai?ei ca a?eii. Noaoenoe/ia ia?iaea iaea?aeaieo
aeaieo aeeiiaia ia eiii’thoa?? c aeei?enoaiiyi noaiaea?oieo iaeao?a
i?ia?ai “Microsoft Excel”.

?iciianthaeaeai?noue aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o
oaooa??a ??cieo i?ioan?eieo a?oii ? ca’ycie c a??ie/iaaieia?/ieie
oiiaaie oaoo. IA, IA, O? oa ?A ni?aa?aeiinyoueny ye 82,2 : 10,1 : 6,2 :
1,0. I?iii?oe?th /anoioe aeyaeaieo a?o?ic?a oa a?o?eo?a o I?, I?ae, IAN,
IAAI, IA?, A?IA oa E? iiaeia i?aaenoaaeoe ye 2,9 : 2,4 : 1,5 : 1,3 : 1,2
: 1,0 : 1,0.

Eiao?oe??ioe ei?aeyoe?? iieaciee?a ?iciianthaeaeaiino? caoai?thaaiue
noaeia?a o ?ia?oiee?a, eio?? i?aoeththoue a oaooao c a??ie/iaaieia?/ieie
oiiaaie a?aeia?aaeaii a oaae. 1.

Oaaeeoey 1

Eiao?oe??ioe ei?aeyoe?? i?ae iieacieeaie ?iciianthaeaeaiino?
caoai?thaaiue noaeia?a o oaooa??a oa a??ie/iaaieia?/ieie oiiaaie oaoo

Oai-

?iaeA??ie/iaaieia?/i? oaeoi?e1234567

IA

?A

O?

IA

-0,056

+0,063

+0,472*

-0,149

-0,533*

+0,461*

+0,013

+0,576*

+0,455*

-0,020

-0,233

-0,041

+0,502*

-0,167

+0,404

+0,031

-0,221

+0,448

-0,272

-0,197

+0,417

-0,499*

-0,035

+0,062

-0,279

+0,112

-0,232

+0,507*

I?ei?oee:

1. (ooo ? ia ianooiiiio iaethieo) 1 – aeeaeia ?ic?iaie, 2 – oaiia?aoo?a
iia?o?y, 3 – iiooaei?noue aoa?eueieo oa??a, 4 – eoo iaoeeo aoa?eueieo
oa??a,

5 – aeiaaeeia aeai?a, 6 – aaniethoi? aiaeii?eoiee, 7 – a?aeiini?
aiaeii?eoiee;

2. * – ei?aeyoe?y noaoenoe/ii aeinoia??ia.

Caoai?thaai?noue IA caeaaeeoue a?ae iiooaeiino? oa eooa iaoeeo
aoa?eueieo ieano?a, ?A – a?ae oaiia?aoo?e ?iai/i? ciie oa ??aiy
a?aeiinieo aiaeii?eoie?a. O?eueee ia ee?i?/ii iai?oanoiee IA no?aaeaea?
31,9% a??iee?a aoa?eueieo oaoo, ui a 11,8 ?aca ia?aaeuo? aiaeia?/i?
aeai? a iiioeyoe?? aei?ineiai /ieia?/iai ianaeaiiy. Aeyaeaii o?niee
aca?iica’ycie i?ae neeiaei iaaaioaaeaiiyi ia eie?ii? noaeiae oa
iieacieeaie iioe?aiino? aiia?o?ico. IA ca?a?no?iaaii a 31,5 ?aca, a O? a
35,8 ?aca /ano?oa, i?ae a iiioeyoe?? /ieia?e?a – iaoaooa??a.

Oyaee?noue ia?aa?ao oai?ia noaeia?a a?aeia?aaeathoue ?iaeaen ??/? (??)
oa ?iaeaen Eainao?? (?E). I?e IA oe? iieacieee a?aeiia?aeii neeaee
1,3±0,10 ? 4,0±0,32, i?e O? – 5,5±0,39 ? 10,1± 0,71, i?e IA – 8,7±0,15 ?
11,3±0,20, i?e ?A – 21,9±1,18 ? 57,2±2,80.Caeaaei?noue ?? oa ?E a?ae
a??ie/iaaieia?/ieo oa?aeoa?enoee oaoo iiaeaii a oaae. 2.

Oaaeeoey 2

Caeaaei?noue ee?i?/iiai ia?aa?ao oai?ia noaeia?a o oaooa??a a?ae
a??ie/iaaieia?/ieo oaeoi??a oaoo (r)

Oaeoi?eCaoai?thaaiiyIA?AO?IA???E???E???E???E1

2

3

4

5

6

7+0,13

-0,17

-0,47*

+0,25

-0,25

-0,06

+0,32+0,15

-0,10

-0,68*

+0,27

-0,28

-0,09

+0,33+0,10

+0,48*

-0,19

-0,11

+0,51*

-0,28

+0,21+0,10

+0,51*

-0,16

-0,19

+0,32

-0,50*

+0,10+0,51*

+0,11

-0,29

+0,35

-0,10

+0,01

-0,01+0,38

+0,02

-0,12

+0,28

-0,15

-0,11

-0,07+0,08

+0,29

-0,17

+0,02

-0,22

-0,01

+0,22-0,08

+0,54*

-0,16

-0,07

-0,11

0,11

+0,45

I?ei?oee:

1. 1 – aeeaeia ?ic?iaie, 2 – oaiia?aoo?a iia?o?y, 3 – iiooaei?noue
aoa?eueieo oa??a, 4 – eoo iaoeeo aoa?eueieo oa??a, 5 – aeiaaeeia aeai?a,
6 – aaniethoi? aiaeii?eoiee, 7 – a?aeiini? aiaeii?eoiee;

2. * – ei??aeyoe?y noaoenoe/ii aeinoia??ia.

Aeaui ianiiae?aaieie aeyaeeeny iaaaoeai? ei?aeyoe?ei? ca’ycee ?? oa ?E c
iiooaei?noth ?ic?iaethaaieo aoa?eueieo ieano?a o a?oi? oai?eo ia IA,
ine?eueee e?euee?noue o?aaeaieo noaeia?a — noaeiaiaee ?aooiie o oeeo
oaooa??a iaea i?yio caeaaei?noue a?ae oeueiai a??ie/iaaieia?/iiai
oaeoi?a (?2 = 11,268, ?<0,01). Aei oiai ae, ?E /?oei ni?aa?aeiineoueny c? nooiaiai neeiaiai iaaaioaaeaiiy ia eie?ii? noaeiae (r = +0,485), a oa, a naith /a?ao, c oiaueiith aoa?eueieo ieano?a (r = +0,936). Ia?aaaaeio a?eueo?noue c caoai?thaaiiyie noaeia?a neeaaeaee oaooa?? c I (I) oa A (II) a?oiaie e?ia? ? Rh+. Iaeiae ia i?ioeaaao caei?iaei a??ieeai AA (IV) oa A (III) a?oie e?ia? c Rh- cono??/aeenue iaeiaeiai /anoi. Aa?oi caoaaaeeoe, ui oaooa?yi, eio?? no?aaeaeathoue ia IA, iaea?eueo oeiiaa A (II) Rh- a?oia e?ia?, iaeiaio – AA (IV) Rh-, a c caiaeueieie caoai?thaaiiyie noaeia?a - I (I) Rh+, oiae? ye AA (IV) Rh+ acaaae? iaoa?aeoa?ia. Aeniea /anoioa aeyaeaiiy aioeaaio HLA A27 i?e OA noaea oaea o?anoiiao?eiith. Iii?oia oaeiae cieaeaiiy /anoioe, c yeith o?aieythoueny aioeaaie A9, A7, A12, A35 oa A40. HLA-oaiioeie A5 ? A27, A7 ? A12, A12 ? A27, A1 ? A27, A2 ? A27, A10 ? A27, A11 ? A27, A19 ? A27 neoaeaoue iiceoeaieie ia?ea?aie aeey oeaio?aeueii? ? ia?eoa?e/ii? oi?i caoai?thaaiiy. Aeey ia?eoa?e/ii? OA ia a?aei?io a?ae eiio?ieth oa oeaio?aeueii? oi?ie oa?aeoa?ia i?aeaeuaiiy /anoioe, c yeith cono??/athoueny A1 ? A11, A2 ? A13. A iaoiaaiac? oa ae?aaiinoeoe? O? o oaooa??a aaaeeeai? ?ie? iaaea?oueny oaeiae aioeaaio a?noinoi?niino? A27. A?aei?/a?oueny i?aeaeuaiiy /anoioe aioeaai?a A9, A12, A35, oiae? ye aioeaaie A3, A9, A10, Aw19, A28, A5, A13, A16 – A21 ?a?no?othoueny ??aeoa, i?ae o iiioeyoe??. Uiaei aioeaai?a eieono N, oi onoaiiaeaii cieaeaiiy ?iciianthaeaeaiino? na?aae oai?eo O? Nw3 oa Nw6. Ii?aeiaiiy A2, A27, Nw2, yea aeyaey?oueny o ianoaaeaieo c O?, ia cono??/a?oueny a a?oi? caei?iaeo ethaeae. Iniaeeaino? ia?aa?ao caoai?thaaiue noaeia?a o oaooa??a-aoa?eueiee?a. A??ieee c IA iiaeaeoaee a?ae/oaathoue a?o?aea?? o niiei?. O A?IA, IA? oa I? iiaea niinoa??aaoeny ia iineeaiiy, a iineaaeaiiy aieth i?ae /an ?ooo ia e?iaoeue ?iai/i? ci?ie c /a?aiaei aeieeiaiiyi ?o aii/? (/iai, aei ?a/?, ia a?ae/oaathoue oaooa?? ?ioeo i?ioan?e). O 13,6% oaooa??a iniiaieo a??ie/eo i?ioan?e IA ee?i?/ii aino?i aeaathoo? c neiia?oo, ia oa?aeoa?iee “neiioii aeieaaee”, a /anoi ?aeeiith eieae?caoe??th noa? caeo/aiiy aei iaoieia?/iiai i?ioeano iea/iaeo oa e?eoueiaeo noaeia?a. ?aieiaa neoo?noue i?eoaiaiia caoai?thaaiith o 2/3 IA? ? I?. 81,0% IAN oa 95,2% IAAI a?o?aea?? a eie?iieo c/eaioaaiiyo a?ae/oaathoue ia aa/?? i?ae /an oiaeueae. I?e/eiaie aieth o ?ac? i?ioan?eiiai IA o oaooa??a ? ?N, ia?ea?o?eo ? niaci i?eeaaeeo i’yc?a. Iaea?eueo /anoith eieae?caoe??th IA a aeaatho? caoai?thaaiiy ? eie?ii? noaeiae, ui a?aei?/aii a?eueo ye o 2/3 oai?eo. Ne?ae cacia/eoe, ui c aiia?o?ico ii/eia?oueny iaoieia?/iee i?ioean a on?o aac aeiyoeo E? ? IA?. O I?, A?IA oa IAAI cia/ii /ano?oa cono??/athoueny o?aaeaiiy iea/iaeo ? e?eoueiaeo noaeia?a. Cia/ia ?iciianthaeaeai?noue noaeiaiaiai neiae?iio niinoa??aa?oueny o I?, IAAI, IAN oa AI. O?oaeiaa ae?yeuei?noue A?IA o?nii iia’ycaia c a?o?icii e?eoueiaeo noaeia?a, I? – iea/iaeo oa e?eoueiaeo, E? – eie?iieo, IAAI – e?eoueiaeo, eie?iieo oa aii?eeiainoiiieo, IA? – eie?iieo oa aii?eeiainoiiieo, IAN – i?iiaiaaicai’ynoeiaeo, iaeueoe?a ?oe ? ieneiainoaaiiaeo, AI – eie?iieo ? aii?eeiainoiiieo. Neiao?e/i?noue o?aaeaiiy noaeia?a aeineoue oeiiaa aeey A?IA ? IAAI, ?aieiaa neoo?noue – aeey IA?, iineeaiiy aieth ia e?iaoeue aeiy – aeey A?IA, IAAI oa IAN, ciaioaiiy aieth ia e?iaoeue aeiy – aeey E? ? IA?. O A?IA ? IA? IA ia?aa?aa?, ye i?aaeei, c ?N. Aoi?eiia caiaeaiiy noaeiaiai? iaia?aie i?e iie?inoaia?o?ic? aeineoue oa?aeoa?ia aeey AI. ?icaeoie iie?inoaia?o?ico o A?IA caaaeaee noi?iaiaeaeo?oueny ? neiia?oii. I?ae oei, iiiiie?aia?o?ic c neiia?oii o IAAI niinoa??aa?oueny aeoaea ??aeei. O iaoaeo?a?a, eienio?i?e?a oa iaoeiiaoae?aiee?a cia/ii ??aeoa ?icaeaa?oueny aoi?eiiee ?N. Iniaeeai ae?aci? ?ica?aeiino? niinoa??aathoueny a?aeiinii iniiaii? a?oie a??iee?a. Oaooa?yi iniiaieo i?ioan?e aeanoeaee iiaeaeoaee ?aoeeaeeaoth/ee ia?aa?a ?N ? a?eueo oaeaeea i?ia?anoaaiiy IA. Aeey iaoaooa??a aaniethoii iaoeiiaee aino?ee ii/aoie IA oa iineaaeaiiy aieth i?e ?ooao, iaea cia/aiiy ia? noa?oiaa neoo?noue. sseui o a??iee?a noia iieaciee?a a?aeiinii? cia/ouino? oeeo iciae neeaaea? 48,7%, oi a ?ioeo ?iai/eo – 1,6%. Iaeoyae/a oi?ia oai?iae oa?aeoa?ia aeey A?IA oa IA?, a iaea?eueo eaae? - E? oa I?. Oyaee?noue ia?aa?ao IA caeaaeeoue a?ae iiooaeiino? aoa?eueieo oa??a. Oaeaeei i?ia?anoth/ee IA eiinoaoiaaii o 40,9% oai?eo iniiaieo i?ioan?eieo a?oi ? eeoa o 24,1% - aeiiii?aeieo (?2 = 4,377). Aac iii?oiiai i?ia?anoaaiiy oai?iaa ia?aa?aa? a?aeiia?aeii o 2,2% ? o 20,4% ?ia?oiee?a ( ?2= 13,970). A oe?eiio ?aioaaiieia?/i? iciaee IA o iaoaooa??a aoee a?eueo ??ciiiai?oieie, i?e/iio caoaeaiiy noaeiaiai? u?eeie, iaaeieinoaeiaiaee oa i?aeo?yuiaee inoaineea?ic, a oaeiae inoaio?oic ca?a?no?iaaii aaea?/? /ano?oa, i?ae o a??iee?a. Iai?ioe, e?aaiaioic aeyaeany oa?aeoa?iei eeoa aeey oaooa??a. Noia on?o iieaciee?a cia/ouino? ?aioaaiieia?/ieo iciae o 1-?e a?oi? neeaea 22,4%, a 2-?e – 57,5%. Iaie i?iaaaeaii ii?oieia?/i? naeoe?ei? aeine?aeaeaiiy eie?iieo noaeia?a o 21 a??ieea, ye? caaeioee aiane?aeie oaooii? o?aaie. A on?o aac aeiyoeo a??iee?a, noaae ?iaioe yeeo o oaoo? neeaaea? iiiaae 5 ?ie?a, a ?acoeueoao? ii?oieia?/ieo aeine?aeaeaiue aeyaeaii ii?ooaiiy no?oeoo?e o?yua. *ano?oa iaae ona ciaiooaaeiny /enei oiiae?ioeeo?a (OOe) (a 100,0% aeiaaee?a), cieeaea iaoao?iiac?y (a 76,2%), ?icaeaaeiny ?icaieieiaiiy, o?aaiaioaoe?y oa ?ico??neoaaiiy o?yua (a 66,6%), ??aeoa cono??/aeeny aeaaaia?aoeaii-iae?ioe/i? ci?iaiiy OOe (33,3%). A neiia?aeuei?e iaieiioe? ao?iooaaeeny iie?eai? ee?oeie (71,4% niinoa?aaeaiue), ciaiooaaeany oiaueia oa?o neiia?ioeeo?a (61,9%), c’yaeyeiny neea?icoaaiiy no?iie (28,6%) oa iaa?yeaiiy aiaeioae?th eai?ey??a (19,1%), iae?ioaaaeueia ?io?eueo?aoe?y (23,8%), a?aeeeaaeaiiy o?a?eio ia iiaa?oi? ai?neiie (19,1%), ia?eaaneoey?ia ieaciaoe/ia iane/oaaiiy (14,3%). Iniaeeaino? ee?i?/iiai ia?aa?ao IA iieyaathoue a aoeiia?e eieae?caoe?? a?o?eoo a aeaatho? caoai?thaaiiy (c caeo/aiiyi eie?iiiai, aii?eeiainoiiiiai oa i?iiaiaaicai’ynoeiaiai noaeia?a) ? a oa?aeoa?? aino?iai /e i?aeaino?iai iie?a?o?eoo. Eeane/ia ea?oeia noaeiaiai? e?ece o a??iee?a aoa?eueieo oaoo a aeaatho? caoai?thaaiiy o aeaeyae? aneiao?e/iiai a?o?eoo ia?oiai ieaniioaeaiaiaiai noaeiaa niinoa??aa?oueny o 4/5 oai?eo IOI oa 3/4 - aeiiii?aeieo oaooa?nueeeo i?ioan?e (AeOI). ?icaeoie ?ioa?i?ooth/i? aai o?ii?/ii? oi?ie IA o oai?eo a??iee?a caeaaeeoue a?ae aeeaeie ?ic?iaie, oaiia?aoo?e iia?o?y, iiooaeiino? oa?a, eooa iaae?iiy, aeiaaeeie aeai?a, a?aeiinieo aiaeii?eoie?a. Eeane/iee ae?aaiinoe/iee e?eoa??e iiaeaa?e - e?noeia? oioone – ye i?aaeei, aeieeathoue /a?ac 2-3 ?iee c iiiaioo ii/aoeo ia?oi? noaeiaiai? e?ece, oi/a o oai?eo IOI o 6,5% aeiaaee?a niinoa??aaeeny i?ae /an ?aioaaiieia?/iiai aeine?aeaeaiiy iiyae “neiioiio i?iaeaa/a” oaea i?ney iaeii?aciai? aoaee. O 8,3% aeiaaee?a oai?eo AeOI c o?ii?/iith oi?iith IA aeano?oeoe?? e?noee ia aoei. Iaeii/anii iiaeia iiaa/eoe caoaeaiiy noaeiaiai? u?eeie, iioiauaiiy i’yeeo iaaeieinoaeiaiaeo oeaiei aiane?aeie o?ii?/iiai caiaeaiiy oa ?io?eueo?aoe?? o?aoaie. O ?ac? ?icaeoeo aoi?eiiiai IA aei oeeo iciae aeiaea?oueny a?eueo /e iaio ae?aaeaiee e?aeiaee inoaio?oic. Aeaui ??aeoa aeyaeyeeny e?oii? e ae??ai? e?noiiiae?ai? i?ina?oeaiiy, i?e/iio o in?a iniiaii? a?oie ia?aaaaeaee ae??ai? e?noiiiae?ai? i?ina?oeaiiy, a o eiio?ieueii? – e?oii? (?2= 4,123). Niaoeeo?/i?noue inoaiii?ico o oai?eo iniiaii? a?oie neeaaea? 65,5%, oi e?aeiaeo oco? - 85,0%. A?aei?/aii noaoenoe/ii aeinoia??i? a?aei?iiino? /anoioe, c yeith cono??/athoueny e?aeia? oco?e (?2= 11,362). A?aeeeaaeaiiy eaeueoe?th aeyaeyeiny o eiaeiiai i’yoiai oai?iai IOI, oiae? ye o oai?eo eiio?ieueii? a?oie aiii niinoa??aaeinue a /ioe?e, a o ?ia?oiee?a - iaoaooa??a – a aeaa ?ace ??aeoa. O oai?eo iniiaii? a?oie oi?ioaaiiy caoaeaiiy noaeiaiai? u?eeie caeaaeaei a?ae iiooaeiino? oa?a, ?icaeoie aea e?aeiaeo oco? aoa iia’ycaiee c iiooaei?noth oa eooii iaae?iiy oa?a. O oai?eo eiio?ieueii? a?oie i?ine?aeeiaoaaany aca?iica’ycie ?aioaaiieia?/ii aeyaeaieo e?aeiaeo oco? oa iiooaeiino?, a oaeiae eooa iaae?iiy oa?a. Ia ooai?aiiy e?noiiiae?aieo i?ina?oeaiue aecia/aeueiee aieea iaee oaeiae aeaa aeuacacia/aieo a??ie/iaaieia?/ieo oaeoi?e. Ia?oeie a on?o oai?eo oaooa??a o aeaatho? O? o?aaeathoueny aii?eeiainoiii? noaeiae. Ianooiieie iaeaea c iaeiaeiaith /anoioith a iaio a?oiao aeaathoothoue eie?ii? noaeiae, ci?ie ae c aieo noaeia?a noii ia?aaaaeathoue o oai?eo iniiaii? a?oie. Oa?aeoa? o?oaeiai? ae?yeueiino? ?ia?oiee?a IOI ni?ey? ?icaeoeo caiaeaiiy a i?iiaiaaicai’ynoeiaeo noaeiaao oa iaeueoeyo ?oe, a?eueo /anoiio caeo/aiith aei iaoieia?/iiai i?ioeano ieneiainoaaiiaeo oa eie?iieo noaeia?a. Noia iieaciee?a a?aeiinii? cia/ouino? oeeo iciae o oai?eo iniiaii? a?oie neeaaea? 81,8%, oiae? ye o oai?eo eiio?ieueii? a?oie eeoa 6,7%. Oyaee?noue o?aaeaiiy eieiiioi?iiai aia?aoo o oaooa??a iniiaieo i?ioan?e aeua, i?ae o i?aaenoaaiee?a aeiiii?aeieo i?ioan?e. Aiia ia? i?yiee ei?aeyoe?eiee ca’ycie c aeeaeiith ?ic?iaie oa eooii iaoeeo aoa?eueieo oa??a. sseui nooi?iue e?noeiai? aeano?oeoe?? ia?eoa?e/ieo noaeia?a i?e O? cia/ii aeuee o i?aaenoaaiee?a AeOI (a ai?o?ca?iee inoaiii?ic ia? iaa?oue a?aeiinio cia/ou?noue), oi ?icaeoie nae?i?ea?oo aeyaey?oueny a?eueo aeanoeaei oaooa?yi iniiaieo a??ie/eo i?ioan?e. E??i o?aaeaiiy e?eaeiai-caeooaeiieo c/eaioaaiue, ?aooa ?aioaaiieia?/ieo iciae ia ? niaoeeo?/ieie aeey O?, a iiaeooue aooe i?iyaii noiooiueiai i?ioan?eiiai IA. Aeaatho ?A c o?aaeaiiyi iea/iaeo noaeia?a oa noaeia?a noii ??aeei cono??/a?oueny o ?ia?oiee?a IOI, a oie /an ye aeey oai?eo AeOI oaea eieae?caoe?y noaeiaiaiai i?ioeano acaaae? iaoa?aeoa?ia. Caoai?thaaiiy ia ?A a on?o oaooa??a /ano?oa iaae ona ii/eia?oueny c o?aaeaiiy noaeia?a eeno?a, eie?iieo oa aii?eeiainoiiieo noaeia?a. Noaeiaiaee ?iaeaen, ?? oa ?E ?noioii aeuee o oai?eo iniiaii? a?oie, ui na?ae/eoue i?i a?eueo iioe?aiee ? oyaeeee noaeiaiaee neiae?ii oe??? eaoaai??? oai?eo. ?? i?yii ei?aeth? c oaiia?aoo?ith iaaeieeoiueiai na?aaeiaeua, aeiaaeeiith aeai?a, a oie /an, ye ?E - c oaiia?aoo?ith iaaeieeoiueiai na?aaeiaeua oa cai?ioii ei?aeth? c aaniethoieie aiaeii?eoieaie. Iaea?eueo iaoiaiiiii?/iei ia ?aii?o noaae?yo caoai?thaaiiy a iaio a?oiao oaooa??a aeyaey?oueny ii?aeiaiiy caoaeaiiy noaeiaiai? u?eeie oa iaaeieinoaeiaiaiai inoaiii?ico. Oco?aoe?y noaeiaiaeo iiaa?oiiue, yea cono??/a?oueny a ianooiieo ?aioaaiieia?/ieo noaae?yo, /ano?oa niinoa??aa?oueny o oai?eo eiio?ieueii? a?oie. I?aeaeaeo?a o oai?eo IOI iaie ia aoei aeyaeaii. Iaea?eueo iaoiaiiiii?/iith iciaeith OA a on?o oai?eo oaooa??a ? o?aaeaiiy o?aaoa a ??cieo eiai a?aeae?eao. *ano?oa iaae ona o?aaea?oueny iiia?aeiaee a?aeae?e o a??iee?a, iacaeaaeii a?ae ?o i?ioan??, o?ioe ??aeoa e?eaeiai-caeooaeiia c/eaioaaiiy oa oeeiee a?aeae?e o?aaoa, uii?aaaea, o in?a AeOI inoaii? aeaa a?aeae?ee o?aaoa aei iaoieia?/iiai i?ioeano caeo/athoueny ??aeoa. A oie aea /an ci?ie, ui a?aeaoeeny a a?oaeiiio a?aeae?e? o?aaoa oai?eo iniiaii? a?oie, iinooiathoueny ca /anoioith ia?aae eiio?ieueiith a?oiith. Iaea?eueo /anoiai o?aaeaiiy o oai?eo iniiaii? a?oie caciathoue eie?ii? noaeiae, a oie /an ye o eiio?ieuei?e a?oi? aiii cono??/a?oueny iaeaea a 4 ?ace ??aeoa. A?o?eo eie?iiiai noaeiaa o oaooa??a, eio?? no?aaeaeathoue ia OA, ia?aa?aa?, iane?aeoth/e oei o?ii?/iiai a?ae?ia?o?ico c aeiioii neaaeicaiaeueiiai oa?aeoa?o ? aeineoue ??aeei caaa?oo?oueny e?noeiaei aie?eicii. Aeineoue /anoi o?aaeathoueny i?iiaiaaicai’ynoeia? noaeiae, iaeiae a eiio?ieuei?e a?oi? oey eieae?caoe?y i?ioeano oaeiae iaeaea aaea?/? iinooia?oueny ia?aae iniiaiith a?oiith. O eiaeiiai i’yoiai ?ia?oieea IOI, eio?? no?aaeaeathoue ia OA, iayai? ci?ie aii?eeiainoiiieo noaeia?a ? noaeia?a eeno?, oiae? ye o in?a AeOI oeacai? ci?ie iaeioa?aeoa?i?. ?noioia c?inoaiiy ?? oa ?E a iniiai?e a?oi? na?ae/eoue i?i a?eueoa iioe?aiiy ? oyaee?noue noaeiaiaiai i?ioeano o oe??? eaoaai??? oai?eo, ? ui ia iaio aaaeeeai – i?i a?eueo /anoa o?aaeaiiy o ieo e?oiieo noaeia?a. Iaea?eueo ?aiiueith ? aenieiniaoeeo?/iith iciaeith caoai?thaaiiy ? o?aaeaiiy e?eaeiai-caeooaeiieo c/eaioaaiue – aeainoi?iii?e nae?i?ea?o, iayaiee o 4/5 oai?eo iniiaii? a?oie ? iaeaea o 3/4 – eiio?ieueii?. O 76,9% ?ia?oiee?a IOI, eio?? no?aaeaeathoue ia OA oa 50,0% aeiiii?aeieo – aeyaey?oueny aeainoi?iii?e i?ioean. Aeineoue /anoi ?aioaaiieia?/iith iciaeith ? caoaeaiiy noaeiaiaeo u?eei noaeia?a, yea niinoa??aa?oueny iaio ye o iieiaeie oai?eo iniiaii? a?oie, a oie /an ye o oai?eo eiio?ieueii? a?oie oey iciaea i?iyaey?oueny aaea?/? ??aeoa. Ineo?eaoe?y ca’ycie o?aaoe?a oa?aeoa?ia aeey a?eueo i?ciuei? noaae?? oai?iae ? aecia/a?oueny o 1/3 oai?eo iniiaii? a?oie oa 1/4 - eiio?ieueii?. O eiaeiiai i’yoiai oai?iai OA IOI aeieea? e?noiiiae?aia ia?aaoaeiaa noaoiiae?aeueii? e?noee, cieaeaiiy aenioe i?aeo?aaoeaaeo aeene?a, i?aeo?yuiaee inoaineea?ic, a oie /an ye aeey oai?eo aeiiii?aeieo i?ioan?e ia?o? aea? iciaee iaio oa?aeoa?i?, a i?aeo?yuiaee inoaineea?ic, iaaiaee, ? a?eueo oeiiaei. Ieoaiiy iaoiaaiaco aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o a??iee?a aoa?eueieo oaoo. Iniiaiith i?e/eiith ?icaeoeo caoai?thaaiue noaeia?a o a??iee?a aoa?eueieo oaoo ? iaa?aeiia?aei?noue i?ae iaoai?/iei iaaaioaaeaiiyi, yea iaaea? ia noaeiaiao iiaa?oith o?yua, ? eiai iiaeeeainoyie /eieoe ii?? oeueiio iaaaioaaeaiith. Iiae?aia neooaoe?y noai?th?oueny i?ae /an oyaeei? o?ce/ii? i?aoe? c /anoi iiaoi?thaaieie noa?aioeiieie ?ooaie, ye? aieeaathoue ia iaei? e o? ae noaeiae. Na?aae aeiaeaoeiaeo iaoiaaiaoe/ieo iiiaio?a IA, e??i o?eaaei? i?e?io?aaiaoecaoe?? ? ooieoe?iiaeueiiai ia?aaaioaaeaiiy noaeia?a, aaeeeiai cia/aiiy iaaea?oueny noaeeiiei a?oeeoey?iei ?iceaaeai. Ii?ooaiiy e?iaiia?ao aaaaoi a /iio iaa?oue aecia/a? ia?aa?a oai?iae. ?aia?ao?/i? ci?ie aeacothoue ia ae?aaeai? ii?ooaiiy iniiaieo iieaciee?a ?aa?iia?iiai e?iaiia?ao, aeeth/ath/e oiion noaeei ? oiiae e?iaioieo. A?eueoa oiai, oe? ii?ooaiiy ei?aeththoue c oyaee?noth noaeiaiaiai i?ioeano. Aaaeea o?ce/ia i?aoey oaooa??a a oiiaao iaa??aath/iai i?e?iee?iaoo aeeeeea? ci?ie ??aiy e?i?ae?a ? noaoaaeo ai?iii?a o e?ia?, ye? o?nii iia’ycai? c a??ie/iaaieia?/ieie oiiaaie oaoo. Iaa?oue o i?aeoe/ii caei?iaeo a??iee?a niinoa??aa?oueny i?aeaeuaiiy a ne?iaaooe? e?ia? ON ? OA, a?aeaoaa?oueny aeenaaeain ai?noo e?iii?ioa?ae?a (EI), i?eai?/o?oueny nae?aoe?y O. O oaae. 3 iiaeai? cia/aiiy caaaeueiiai ON, OA ? ie?aieo o?aeoe?e EI o e?ia? ianoaaeaieo oaooa??a. Ai?no OA, caaaeueiiai ON ? ON ?-EI o a?eueo?e i??? ca?eueooaaany i?e IA. O oai?eo ia ?A eiioeaio?aoe?y OA ?noioii ia i?aeaeuo?oueny, a o ?ia?oiee?a c IA ? O? oe? iieacieee acaaae? ia ci?ithaaeenue. Oaaeeoey 3 ??aaiue e?i?ae?a o e?ia? oaooa??a (M±m) A?oie oaooa??aE?i?aeeONOAe?iii?ioa?aee (%)(iiie/e)(iiie/e)?i?a-??Oai??: IA ?A O? IA 5,5±0,12 5,1±0,17 6,0±0,33 7,7±0,21* 1,6±0,08 2,1±0,24* 1,2±0,03 3,2±0,13* 23,9±0,45* 28,5±0,93* 26,5±1,58* 29,7±1,97 20,2±0,34* 25,7±0,68 22,6±2,11 35,4±2,28* 55,9±0,87* 45,8±1,20* 51,0±3,65* 34,4±1,15*Caei?ia?5,3±0,151,4±0,1032,7±0,7626,5±0,5941,7±0,92 I?ei?oea. * – a?aei?iiino? i?ae aiaeia?/ieie iieacieeaie o oai?eo ? caei?iaeo noaoenoe/ii aeinoia??i?. O eiaei?e ?c niinoa?aaeoaaieo a?oi oai?eo eiinoaoiaaii ia?a?iciiae?e ON o ??cieo eeanao EI. I?e IA ??aaiue ON i?a-?-EI ? ON ?-EI neeaa a?aeiia?aeii 130,9% oa 115,5% eiio?ieueieo cia/aiue, a i?e IA – a?aeiia?aeii 195,2% oa 155,5%. ?A oa?aeoa?ecoaaany cieaeaiiyi ai?noo ON i?a-?-EI ia 19,1% ? iacia/iei i?aeaeuaiiyi ON ?-EI ia 11,4%. Oae, o A?IA, AI ? IAAI ??aaiue O a e?ia? aoa aeinoia??ii ieae/ei, i?ae o ?ia?oiee?a ?ioeo i?ioan?e. Iieacieee I oaeiae ?noioii cieaeai? o A?IA, IA?, AI ? IAAI. ??aaiue A i?aeoe/ii ia a?ae??ciy?oueny eeoa o IA? ? AI, iaeiae yeui o AI a?i aeinoia??ii i?aaaeth? iaae iieacieeaie caei?iaeo – iaoaooa??a, oi o I?, A?IA, E?, IAN, IAAI a?i ?noioii cieaeo?oueny. O a??iee?a c ?A iaie aeyaeaia ??cea i?eai?/aiiy ??aiy O, yeee ia caeaaeeoue a?ae i?ioan?? ianoaaeaieo (oaae. 4). Oaaeeoey 4 ??aaiue noaoaaeo oa aiiaaeio?iiieo ai?iii?a o e?ia? oaooa??a (M±m) Ai?iiieAei??A?oie ianoaaeaieo oaooa??aoai??caei?ia?IA?AIA????????? O A I E O iiie/e iiie/e iiie/e II/ie II/ie 12,5± 0,66* 0,05± 0,002* 2,7± 0,84* 10,2± 0,55* 6,8± 0,22 11,9± 0,54* 0,04± 0,005* 0,7± 0,09*)** 8,9± 0,32* 6,9± 0,31 6,2± 0,43* 0,10± 0,008 0,9± 0,10 8,0± 0,54* 6,8± 0,27 6,1± 0,32* 0,16± 0,007*)** 1,0± 0,09* 9,1± 0,55* 7,2± 0,68 7,0± 0,58* 0,04± 0,004* 9,0± 1,15* 15,2± 0,70* 6,5± 0,29 8,3± 0,62* 0,05± 0,003* 3,1± 0,35*)** 13,1± 1,12* 7,3± 0,81 19,8± 0,89 0,09± 0,009 0,62± 0,077 5,8± 0,18 6,6± 0,39 I?ei?oee: 1. ? – oaooa?? iniiaieo i?ioan?e, ?? – oaooa?? aeiiii?aeieo i?ioan?e; 2. * – a?aei?iiino? i?ae aiaeia?/ieie iieacieeaie o oai?eo oa caei?iaeo noaoenoe/ii aeinoia??i?; 3. ** – a?aei?iiino? i?ae aiaeia?/ieie iieacieeaie o oai?eo oaooa??a iniiaieo oa aeiiii?aeieo i?ioan?e noaoenoe/ii aeinoia??i?. sseui o oai?eo ia ?A a a?oi? IOI ai?no A ? I ia a?ae??ciy?oueny a?ae caei?iaeo a??iee?a, oi o oaooa??a aeiiii?aeieo i?ioan?e a?aecia/aeenue /?oea a?ia?ano?aae?ieai?y ? a?ia?i?iaanoa?iiai?y. Ni?aa?aeiioaiiy A/O a 1-e a?oi? noaiiaeoue 16,1 . 10 –3, a 2-e – 26,2 . 10 –3. Ie aaaaea?ii, ui iaio ae?aaeai? ai?iiiaeuei? ii?ooaiiy o oai?eo ia ?A IOI coiiaeai? ia oa?aeoa?ii i?ioan?eii? ae?yeueiino?, a iniaeeainoyie ia?aa?ao caoai?thaaiiy. O oai?eo ia IA a iaio a?oiao aeyaeaii ??aiioe?iia ciaioaiiy a e?ia? O ? A. sseui o oaooa??a aeiiii?aeieo i?ioan?e ai?no I iaeaea ia ci?ith?oueny, oi o oaooa??a iniiaieo i?ioan?e niinoa??aaeanue i/aaeaeia a?ia?i?iaanoa?iiai?y. I?e IA aeyaeaii cieaeaiiy a e?ia? aiae?iaai?a ? ano?iaai?a, iaeiae oanoinoa?iiai?y a 1-e a?oi? i?eai?/oaaeanue o a?eueo?e i???, ? a?aeiia?aei? iieacieee aeinoia??ii a?ae??ciyeenue ia o?eueee a?ae eiio?ieueieo aaee/ei (caei?iaeo oaooa??a), aea e a?ae oai?eo 2-? a?oie. Eiioeaio?aoe? EIIA ? EIAeIA o oai?eo ia IA iaee i?yi? ei?aeyoe?ei? ca’ycee c aeeaeiith aoa?eueieo ?ic?iaie (a?aeiia?aeii r = +0,49 i r = +0,51). A iaio?e i??? ?o ??aaiue o oai?eo ia IA caeaaeaa a?ae oaooieo aiaeii?eoie?a (r = +0,34 i r = +0,32). A a?oiao oaooa??a, ui no?aaeaeathoue ia IA ? ?A, iaie aeyaeaia i?yia caeaaei?noue ON ?-EI a?ae ai?noo a ieaci? O (a?aeiia?aeii r = +0,42 i r = +0,32). O oai?eo ia IA ? IA ca?a?no?iaaia iaaaoeaia ei?aeyoe?y aiae?iaaio c ??aiai ON ?-EI (a?aeiia?aeii r = -0,44 i r = -0,45). O an?o a?oiao onoaiiaeaii noaoenoe/ii aeinoia??iee cai?ioiee ca’ycie oanoinoa?iiai?? c o?eae?oea?eaeai??th (r neeaaea? a?ae – 0,36 aei – 0,66). E??i oiai, i?e IA ? IA niinoa??aaeanue iiceoeaia ei?aeyoe?y i?ae eiioeaio?aoe?yie ON ?-EI ? A (a?aeiia?aeii r = +0,36 i r = +0,56). I?e aeaaaia?aoeaii-caiaeueieo caoai?thaaiiyo noaeia?a c?inoa? ai?no AeE ? i?eaeooo?oueny ??aaiue OO, i?e/iio o a??iee?a oe? ci?ie aeyaeeenue iaaaaaoi ?noioi?oeie. A?eueoa oiai, noa? aeoaea aenieith ? eiioeaio?aoe?y IAe. Inoaiiy ianoaaeia, aacia?a/ii, iaeo?ni?oa iia’ycaia c oiiaaie i?ioan?eii? ae?yeueiino? oaooa??a, iani?eyoeeaeie oaeoi?aie oaoo. Iayaia ? ca?eueoaiiy ii?ooaiue IIE o oai?eo oaooa??a iniiaieo i?ioan?e ii??aiyii c oai?eie a??ieeaie aeiiii?aeieo i?ioan?e. Aa?oa oaaae oa, ui aenieee ??aaiue AeE (a?eueoa 2,9 I/ie aai > M+3m caei?iaeo
?iai/eo) ? iecueeee OO (iaioa 7,06 iiieue/e aai < I – 3m caei?iaeo) anoaiiaeaiee iaie o an?o aac aeiyoeo i?aecaiieo ?iai/eo. I?ioan?eia ae?yeuei?noue a??iee?a iia’ycaia ?c ca?eueoaiiyi o e?ia? eiioeaio?aoe?? NE, II ? EI. O oai?eo ia IA iaee i?noea ae?aaeai? c?ooaiiy iaoaaie?cio io?ei?a, aea o i?aaenoaaiee?a 1-? a?oie aiie aeyaeeenue iaaaaaoi ?noioi?oeie. Iaie anoaiiaeaiee ei?aeyoe?eiee ca’ycie i?ae iieacieeaie io?eiiaiai iai?io i?e iiaeaa?? o a??iee?a ? a??ie/iaaieia?/ieie oiiaaie oaoo. Aeaui ianiiae?aaieie aeyaeeenue ?acoeueoaoe ianoaaeaiiy oai?eo ia ?A, i?e yeiio oaeiae aeyaeaiee aeineoue cia/iee aeeniaoaaie?ci io?ei?a, i?e/iio o oaooa??a 1-? a?oie a?i aoa ae?aci?oee. A?eueoa oiai, eiioeaio?aoe?y EI noaoenoe/ii aeinoia??ii ia?aaeuoaaea oaeo ae naio o 2-e a?oi? oai?eo. IA o a??iee?a noi?iaiaeaeo?oueny a?ia?o?eeai??th, ui cian?i iaoeiiaa aeey ia?aa?ao oai?iae. O 2-e a?oi? ? eeoa oaiaeaioe?y aei i?aeaeuaiiy ??aiy NE o e?ia?, a na?aaei? iieacieee caeeoathoueny aeiionoeieie aeey caei?iaeo /ieia?e?a. Naia ?iaioa a oaoo?, iaa?oue o caei?iaeo ?ia?oiee?a, aiineoue nai? ei?aeoeae o ??aaiue OeI ? IA o e?ia? (oaae. 5). Oae, yeui o i?aaenoaaiee?a iaoaooa?nueeeo i?ioan?e aeyaeaiee i?yiee ei?aeyoe?eiee ca’ycie i?ae ai?noii oeAIO ? IA-A2, oi a a??iee?a – cai?ioia caeaaei?noue OeI c eiioeaio?aoe??th IA-F2?. Oaaeeoey 5 ??aaiue oeeee?/ieo ioeeaioeae?a oa i?inoaaeaiaeei?a a e?ia? o ianoaaeaieo ?ia?oiee?a (M±m) IieacieeeA?oie ianoaaeaieoIIIIIIIVOeAIO (ieiie/ie) oeAIO (ieiie/ie) IA-A2 (ia/ie) IA-F2? (ia/ie) 15,6±2,04 1)4) 27,3±3,15 1) 18,8±2,26 1)4) 26,4±2,72 1)4) 23,9±1,89 2) 29,1±2,15 2) 1,7±0,38 16,0±2,52 2) 28,3±1,36 3) 5,9±0,37 3) 1,4±0,12 6,2±0,70 34,5±2,17 10,1±1,12 1,3±0,15 5,8±0,66 I?ei?oee: 1. ? – oai?? oaooa??, ?? – oai?? iaoaooa??, ??? – caei?ia? oaooa??, IV – caei?ia? iaoaooa??; 2. 1) – a?aei?iiino? i?ae iieacieeaie o oai?eo ? caei?iaeo oaooa??a noaoenoe/ii aeinoia??i?, 2) – a?aei?iiino? i?ae iieacieeaie o oai?eo ? caei?iaeo iaoaooa??a noaoenoe/ii aeinoia??i?, 3) – a?aei?iiino? i?ae iieacieeaie o caei?iaeo oaooa??a ? iaoaooa??a noaoenoe/ii aeinoia??i?, 4) – a?aei?iiino? i?ae iieacieeaie o oai?eo oaooa??a ? iaoaooa??a noaoenoe/ii aeinoia??i?. O a?oi? caei?iaeo oaooa??a a?aei?/ai? a?eueo iecuee? cia/aiiy oeAIO ? oeAIO o ieaci? e?ia? ii??aiyii ?c caei?iaeie iaoaooa?yie. Ai?no IA-A2 ? IA-F2? o aeacaieo a?oiao ?noioii ia a?ae??ciyeenue. A?aecia/eii, ui o oai?eo a??iee?a ??aaiue oeAIO aoa aeinoia??ii ieae/ee, a oeAIO – aeuee a?ae a?aeiia?aeieo iieaciee?a caei?iaeo oaooa??a. I?e oeueiio ai?no IA-A2 ? IA-F2? o ieaci? e?ia? ?acth/a i?aaaethaaa o a??iee?a ?c caoai?thaaiiyie noaeia?a. Iaea?eueo ae?aaeai? cnoae a?aecia/ai? o oai?eo oaooa??a, ye? no?aaeaeathoue ia ?A, i?e oeueiio o a?eueo?e i??? ca?eueooaaany ??aaiue IA-A2, o iaio?e – IA-F2?. I?e IA ? O? o oaooa??a niinoa??aaeenue aiaeia?/i? ci?ie ??aiy IA o e?ia?, iaeiae aiie iineee iaio yne?aaee oa?aeoa?. IA o a??iee?a noi?iaiaeaeoaaany i?i?iaeueieie a?aeoeeaiiyie aeacaieo ia?aiao??a. Caaaeueia /enei O-e?ioioeeo?a ? /enei ?o noaiiioeyoe?e, e?euee?noue A-ee?oei, iieacieee ?AOE ia i?oiaaie ? oaaioeeoa?ii? ooieoe?? iaeo?io?e?a (OOI), a oaeiae eiioeaio?aoe?y on?o ne?iaaoeiaeo ?A o oai?eo ? caei?iaeo oaooa??a i?aeoe/ii ia a?ae??ciyeenue i?ae niaith (oaae. 6). Oaaeeoey 6 Iieacieee ?ioi?oaoo o oai?eo ia IA oa caei?iaeo oaooa??a (M±m) IieacieeeA?oie oai?eo oaooa??aCaei?ia? oaooa??????A-G (a/e) ?A-A (a/e) ?A-I (a/e) ?2-IA (a/e) Oe?E (a/e) INA IOA a-AAA10,9±0,19 2,0±0,11 0,8±0,07 3,9±0,33* 1,3±0,11* 2,77±0,105* 1,84±0,102* 1,6±0,086*10,7±0,28 2,1±0,16 0,9±0,05 3,5±0,24* 0,8±0,08** 2,09±0,099*)** 1,82±0,105* 1,31±0,09210,1±0,25 1,8±0,09 0,8±0,04 1,7±0,49 0,6±0,04 1,13±0,083 1,19±0,101 1,09±0,076 I?ei?oee: 1. ? – oaooa?? iniiaieo i?ioan?e, ?? – oaooa?? aeiiii?aeieo i?ioan?e; 2. Aioeo?ea iiaeaii a eiaa?eoiao cai?ioieo oeo??a; 3. * – a?aei?iiino? i?ae iieacieeaie o oai?eo oa caei?iaeo noaoenoe/ii aeinoia??i?, ** – a?aei?iiino? i?ae iieacieeaie o oai?eo iaio a?oi noaoenoe/ii aeinoia??i?. I?e IA iacaeaaeii a?ae i?ioan?? ianoaaeaieo anoaiiaeaii noaoenoe/ii aeinoia??ia i?aeaeuaiiy o e?ia? ai?noo ?2-IA, IOA ? INA. Iaiao?aeii a?aecia/eoe, ui ??aaiue Oe?E ? a-AAA c?inoaa o e?ia? o?eueee a iaoe??io?a 1-? a?oie, aeinoia??ii a?ae??ciyth/e ?o a?ae iieaciee?a caei?iaeo oaooa??a. Aei oiai ae a?aecia/ai? noaoenoe/ii aeinoia??i? a?aei?iiino? ??aiy Oe?E o oai?eo oaooa??a iniiaieo ? aeiiii?aeieo i?ioan?e. ?AOE ia OAA ? Eii cai?ioii caeaaeaee a?ae aeeaeie ?ic?iaie (a?aeiia?aeii r = -0,409 i r = -0,477), a oeo?e a-AAA – a?ae iiooaeiino? aoa?eueieo ieano?a (r = -0,510). O oai?eo 1-? a?oie INA ii/anoe ni?aa?aeiineeenue ?c nooiaiai oaooieo aiaeieo i?eoie?a (r = +0,364). ??aaiue ?2-IA o caei?iaeo oaooa??a ??cieo i?ioan?e iineoue ??ciini?yiiaaiee oa?aeoa? ii??aiyii c i?aaenoaaieeaie ?ioeo i?ioan?e. I?e ?A, iacaeaaeii a?ae i?ioan?? aoa?eueiee?a, a?ae??ciy?oueny ae?aaeaia ?2-IA-ai?y (?en. 1). Ia a?aei?io a?ae IA i?e caiaeueieo caoai?thaaiiyo noaeia?a o oaooa??a ?noioii ciaioo?oueny caaaeueia /enei O-e?ioioeeo?a oa ?o noaiiioeyoe?e, i?e/iio ae?aaeaia aeai?an?y niinoa??aa?oueny o oai?eo IOI. O oie aea /an ia? i?noea a?ia?aeoeaaoe?y A-e?ioioeeo?a a iaio a?oiao oai?eo oaooa??a, ui i?iyaey?oueny i?aeaeuaiiyi ?o e?eueeino?, a oaeiae i?aeaeuaiiyi ai?noo o ne?iaaooe? e?ia? IA-G, IA-I, Oe?E, INA ? IOA. Onoaiiaeai? ei?aeyoe?? aeacaieo ci?i ?ioiiiai noaoono c aeoeai?noth noaeiaiaiai i?ioeano. O oai?eo ia ?A a?aei?/a?oueny ciaioaiiy O-oaeia??a ? O-noi?ani??a, ui i?iyaey?oueny ??ceei cieaeaiiyi iieacieea ni?aa?aeiioaiiy O-oaeia?e/O-noi?ani?e. wmetafile8? ??A?? ?$???????? ???????yyy???????????? i ??? ????'yy??? ??????? ????yyy???? ???????uiy?????? ?en. 1 Ci?ie iieaciee?a ?ioi?oaoo i?e ?A o oaooa??a ? ?ia?oiee?a ?ioeo i?ioan?e (±% a?aeoeeaiue a?ae ia?aiao??a o caei?iaeo /ieia?e?a a?aeiia?aeieo i?ioan?eieo a?oi) I?ei?oee: 1. ? – oaooa?? iniiaieo i?ioan?e, ?? – oaooa?? aeiiii?aeieo i?ioan?e, ??? – ?ia?oieee iaoaooa?nueeeo i?ioan?e; 2. 1 – O-e?ioioeeoe, 2 – O-noi?ani?e, 3 – A-e?ioioeeoe, 4 – ?AOE-OAA, 5 – ?AOE-Eii, 6 – ?A-G, 7 – ?A-A, 8 – ?A-I, 9 – ?O, 10 – ?2-IA, 11 – Oe?E, 12 – INA, 13 – IOA, 14 – O?I, 15 – OII. I?e iiaeaa??, iacaeaaeii a?ae i?ioan??, ?icaeaathoueny ?noioi? ci?ie ?ioiiiai noaoono, ye? a oe?eiio iiaeia ioe?ieoe ye i?eai?/aiiy O-nenoaie ? OOI. I?e oeueiio iaea?eueo ae?aaeaia aeai?an?y ?o, ye ? i?e ?A, niinoa??aa?oueny o oai?eo IOI. Aeieeath/ee aeenaaeain ?ioii?aaoeyoi?ieo ee?oei i?ecaiaeeoue aei i?aeaeuaiiy ??aiy ne?iaaoeiaeo IA-G, IA-M, IA-A, Oe?E o oaooa??a ??cieo i?ioan?eieo a?oi. ??aaiue IA-A, IA-M i Oe?E o oai?eo iaoaooa??a oaeiae ?noioii i?aaaethaaa iaae a?aeiia?aeieie iieacieeaie caei?iaeo oaooa??a. Oeo?e a-iAeIE o ne?iaaooe? e?ia? oai?eo oaooa??a aeinoia??ii a?ae??ciyeenue a?ae oaeeo aea o a?oi? oai?eo ?ia?oiee?a iaoaooa?nueeeo i?ioan?e, i?e/iio, yeui a in?a IOI oe? oeo?e i?aeoe/ii ia a?ae??ciyeenue a?ae iieaciee?a o caei?iaeo oaooa??a, oi a in?a AeOI – ?noioii ia?aaeuoaaee ?o. Iayai?noue a-iAeIE aeaco? ia iiaeeea?noue ?icaeoeo aooi?ioiieo ?aaeoe?e i?e iiaeaa??. ?2-IA-ai?y iaea i?noea o an?o oai?eo ia iiaeaa?o, iaeiae a in?a IOI ? AeOI aiia aeinoia??ii i?aaaethaaea iaae ??aiai ?2-IA o oai?eo iaoaooa?nueeeo i?ioan?e. O oai?eo c caiaeueieie caoai?thaaiiyie noaeia?a ??aaiue ??E-2? a i?aai?ci? ca?eueoo?oueny. Ai?no ??E-2? o caei?iaeo oaooa??a ? oai?eo ia ?A ei?aeth? c ?yaeii ee?i?ei-eaai?aoi?ieo ia?aiao??a, ye? a?aeia?aaeathoue aeoeai?noue ?A. I?e IA o oaooa??a ?icaeaa?oueny cieaeaiiy o e?ia? ??aiy Na++ ? i?aeaeuaiiy IOA ? EO?. Ai?no ia?a?aoiaaieo ai?iii?a o i?aaenoaaiee?a IOI cia/ii ia?aaeuoaaa oae? iieacieee o ?ia?oiee?a aeiiii?aeieo i?ioan?e. sseui eiioeaio?aoe?y EO o e?ia? a??iee?a iniiaii? a?oie ?noioii i?eai?/oaaeanue, oi a eiio?ieuei?e a?oi? ianoaaeaieo oai?eo i?aeoe/ii ia ci?ithaaeanue. sseui o caei?iaeo a??iee?a ni?aa?aeiioaiiy EO/IOA o e?ia? noaiiaeei a na?aaeiueiio 1:2, oi o oai?eo oaooa??a AeOI – 1:3, a a in?a IOI, ye? no?aaeaeathoue ia IA, aaea aeinyaaei 1:6. Onoaiiaeai? ei?aeyoe?ei? ca’ycee ee??aino Na ? ne?iaaoeiaiai ai?noo eaeueoe?e?aaoeth/eo ai?iii?a c aeeaeiith ?ic?iaie ? oaiia?aoo?ith iia?o?y o ?iai/?e cii? oaoo. I?e ?A oaeiae cieaeo?oueny ??aaiue Na++, iaeiae iieacieee caaaeueiiai Na o an?o oai?eo ca?eueoothoueny. Ai?no IOA ? EO? o oai?eo ia?aaeuo? iieacieee o caei?iaeo oaooa??a, oi/ ?noioi? a?aei?iiino? i?ae iniiaiith ? eiio?ieueiith a?oiaie ana-oaee a?aenooi?. Eiioeaio?aoe?y EO iaeiioeiii i?eai?/o?oueny o e?ia? oaooa??a, ye? no?aaeaeathoue ia ?A, iacaeaaeii a?ae oa?aeoa?o ?o o?oaeiai? ae?yeueiino?. ??aaiue caaaeueiiai Na o oaooa??a ??cieo i?ioan?eieo a?oi aeinoia??ii ia?aaeuo? iieacieee caei?iaeo, oiae? ye ai?no caaaeueiiai Na o e?ia? ?ia?oiee?a ?ioeo i?ioan?e ? caei?iaeo ethaeae i?aeoe/ii ia a?ae??ciyany. I?e oeueiio Na-ai?y o oai?eo IOI ?noioii i?aaaeth? iaae oaeith o ?ia?oiee?a aeiiii?aeieo i?ioan?e ? ua a a?eueo?e i??? – o ?ia?oiee?a ?ioeo i?ioan?e. O oie aea /an ??aaiue Na++ aeinoia??ii cieaeoaaany o an?o oai?eo, ye? no?aaeaeaee ia iiaeaa?o. Ai?no IOA ? EO? o ieo ia?aaeuoaaa iieacieee caei?iaeo oaooa??a, iaeiae a in?a iniiaii? a?oie aeacai? iieacieee aeinoia??ii i?aaaethaaee iaae iieacieeaie eiio?ieueii? a?oie ? ?ia?oiee?a ?ioeo i?ioan?e. Eiioeaio?aoe?y EO i?eai?/oaaeanue o oai?eo iniiaieo a??ie/eo i?ioan?e, oiae? ye o oai?eo aeiiii?aeieo i?ioan?e ? ?ia?oiee?a ?ioeo i?ioan?e aiia ia?aaeuoaaea iieacieee caei?iaeo in?a. Iaie anoaiiaeai? ei?aeyoe?ei? ca’ycee aeeiai?/ieo i?aeoacieo oaic?ia?ai (AeIO) ne?iaaoee e?ia? e na/? o caei?iaeo a??iee?a c a??ie/iaaieia?/ieie oiiaaie oaoo (?en. 2). EIE oaic?ia?ai e?ia? i?yii ei?aeth? c aiaeii?eoieaie ? cai?ioii – c aeeaeiith ?ic?iaie ? eooii iaoeeo aoa?eueieo ieano?a. A?aei?/aia i?yia ei?aeyoe?y II2 na/? ? aeeaeie ?ic?iaie, oiae? ye II3 i?yii iia’ycaiee ia o?eueee c aeeaeiith ?ic?iaie, aea e c oaiia?aoo?ith ?iai/i? ciie, eooii iaoeeo aoa?eueieo ieano?a ? aiaeii?eoie?a. O oie aea /an EIE oaic?ia?ai na/? ciaoiaeeoueny o i?yi?e ei?aeyoe?ei?e caeaaeiino? c iiooaei?noth aoa?eueieo ieano?a ? cai?ioi?e – c eooii iaoeeo aoa?eueieo ieano?a. wmetafile8? ??E???B???????? ???????yyy???????????? T??? ????'yy??? ??????? ????yyy???? ???????uiy?????? ?en. 2 Ei?aeyoe?ei? ca’ycee aeeiai?/ieo i?aeoacieo oaic?ia?ai ne?iaaoee e?ia? oa na/? o caei?iaeo a??iee?a c a??ie/iaaieia?/ieie oiiaaie oaoo I?ei?oea. 1 – aeeaeia ?ic?iaie, 2 – oaiia?aoo?a ?iai/i? ciie, 3 – iiooaei?noue aoa?eueieo oa??a, 4 – eoo iaoeeo aoa?eueieo oa??a, 5 – aiaeii?eoiee. I?e ?A o oaooa??a ? ?ia?oiee?a ?ioeo i?ioan?e a?aeaoaa?oueny i?aeaeuaiiy o e?ia? II1, oiae? ye o neoaeaiaoe?a iayaia oaiaeaioe?y aei cieaeaiiy oeueiai iieacieea. II2 ne?iaaoee e?ia? o an?o a?oiao oai?eo ia ?A aeaui ciaioo?oueny, iaeneiaeueii cieaeoth/enue o ?ia?oiee?a AeOI. ?noioiei eieeaaiiyi i?aeeyaa? II3 e?ia?. I?e oeueiio, yeui o neoaeaiaoe?a oeae iieaciee ca?eueoo?oueny o iaio?e i???, oi iaeneioio a?i aeinyaa? o oaooa??a iniiaieo i?ioan?e. I?ei?oii, ui EIE e?ia? o an?o a?oiao oai?eo ia ?A cia/ii ca?eueoo?oueny, oiae? ye EIE na/? – ciaioo?oueny. I?e oeueiio iaeneioi ca?eueoaiiy aeyaeaiee o neoaeaiaoe?a, iaeneioi cieaeaiiy – o ?ia?oiee?a AeOI. II1 ? II2 ne?iaaoee e?ia? ciaioo?oueny o an?o oai?eo ia IA o ??ci?e i???. A in?a AeOI II3 i?aeoe/ii ia a?ae??ciy?oueny a?ae caei?iaeo. O ?ia?oiee?a IOI II3 ia?aaeuo? cia/aiiy a?aeiia?aeiiai iieacieea caei?iaeo in?a, o i?aaenoaaiee?a aea ?ioeo i?ioan?e ? neoaeaiaoe?a – iaaiaee. Ci?ia EIE oaic?ia?ai ne?iaaoee e?ia? e na/? o oai?eo ia ?A iineoue iaeiini?yiiaaiee oa?aeoa? o a?aeiia?aeieo i?ioan?eieo a?oiao, a?ae??ciyth/enue i?ae niaith eeoa ??ciei nooiaiai ae?aaeaiino?. Iaea?eueoa ca?eueoo?oueny II1 ne?iaaoee e?ia? i?e O? o oai?eo IOI, ia?aaaaeath/e iaae a?aeiia?aeiei iieacieeii a in?a c ?A. II2 e?ia? iaeneiaeueii ciaioo?oueny a in?a AeOI, a?ae??ciyth/enue a?ae aiaeia?/ieo iieaciee?a o oai?eo c ?A ? IA. I?e O? a?aeaoaa?oueny i?aeaeuaiiy II3 ne?iaaoee e?ia?, aeinyaath/e iaeneiaeueieo cia/aiue o oai?eo iaoaooa??a. Ia?aiao?e i?aeoacieo oaic?ia?ai N? i?yii ei?aeththoue c II1 e?ia? (a?aeiia?aeii r = +0,73, r = +0,85, r = +0,77, r = +0,46) ? II3 e?ia? (a?aeiia?aeii r = +0,62, r = +0,81, r = +0,69, r = +0,54), aea cai?ioii c EIE (a?aeiia?aeii r = -0,70, r = -0,89, r = -0,73, r = -0,61). sseui a?aooaaoe, ui II1 ne?iaaoee ia? iaaaoeaiee ca’ycie c ??aiai ?A-A, a II2 ? II3 – c eiioeaio?aoe?yie ?A-G, caaaeueiiai ON, EIAA, EIIA ? EIAeIA, oi iiaeia i?eionoeoe, ui ia?a?aoiaai? a?eeia? oa e?i?aei? IA? caeaoi? aecia/aoe aeeiai?/iee II N?. E?eoaaiiy caoai?thaaiue noaeia?a o a??iee?a aoa?eueieo oaoo. ?acoeueoaoe eiiieaenii? oa?ai?? aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a /a?ac 2-3 ?iee a?ae ii/aoeo niinoa?aaeaiiy ca ?ia?oieeaie ie?aieo i?ioan?eieo a?oi iiaeaii a oaae. 7. Oaaeeoey 7 Aoaeoeai?noue e?eoaaiiy caoai?thaaiue noaeia?a o oaooa??a ??cieo i?ioan?eieo a?oi A?oie*enei oai?eoAoaeo e?eoaaiiycia/ia iie?ioaiiyiie?ioaiiyaac ci?iiia??oaiiyaan.%aan.%aan.%aan.% I? A?IA IA? E? IAN I?ae IAAI AI 118 90 28 32 81 18 35 68 12 2 1 - 2 2 - 5 10,2 2,2 3,6 - 2,5 11,1 - 7,4 63 38 21 12 55 2 12 39 53,4 42,2 75,0 37,5 67,9 11,1 34,3 57,4 43 40 6 20 24 14 18 24 36,4 44,4 21,4 62,5 29,6 77,8 51,4 35,3 - 10 - - - - 5 - - 11,1 - - - - 14,3 - ?acii 470 24 5,1 242 51,5 189 40,2 15 3,2 Ia aeaeue, ia an? oaooa?? noai?i aeeiioaaee aeac?aee e?ea??a: 13,7% oai?eo 1-i? a?oie, 28,9% – 2-i? ? 27,6% – 3-i? ii/anoe ?aii?oaaee ?aeiiaiaeaoe??, ui noinothoueny o?eaaeino? e?eoaaiiy, a oea, a naith /a?ao, iaaaoeaii aieeaaei ia caaaeuei? ?acoeueoaoe aoaeoeaiino? ?aaa?e?oaoe?eieo caoiae?a (?2 = 8,64, ?<0,05). A oe?eiio, ?acoeueoaoe niinoa?aaeaiiy ca oai?eie ia iiaeooue oe?eeii caaeiaieueieoe, ine?eueee eeoa o 56,6% ianoaaeaieo ?ia?oiee?a aeinyaiooi iie?ioaiiy ee?i?ei-eaai?aoi?ieo iciae caoai?thaaiue, oa e ia a on?o i?ioan?eieo a?oiao (iai?eeeaae, na?aae I?ae – o 22,2% aeiaaee?a). A?eueoa oiai, o 14,3% IAAI, a oaeiae o 11,1% A?IA eiinoaoiaaii iiaeaeueoa i?ia?anoaaiiy ia?aa?ao oai?iae. Naiaoi?ii-eo?i?oia e?eoaaiiy cia/ii iioaioe?th? ?ai?oa i?iaaaeaio oa?ai?th aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o a?oiao AI oa IAN. O?c?ioa?aiaaoe/i? iaoiaee ?aaa?e?oaoe?? oai?eo oaooa??a aeyaeeenue aeineoue ae??aeie i?e IA, IA oa ?A, a aaeueiai- oa a?ycueie?eoaaiiy – aeeeth/ii aeey ?ia?oiee?a, eio?? no?aaeaeathoue ia IA. Ie ioe?ieee ee?i?/io aoaeoeai?noue ??cieo iaoiae?a eieaeueii? (a?oeeoey?ii?) oa?ai?? eneae?oiiii oai?eo oaooa??a ia IA, ?A oa IA. I?ae iaaeyaeii ia?aaoaaei 277 oaooa??a, oai?eo ia aeaaaia?aoeaii-caiaeuei? caoai?thaaiiy noaeia?a, na?aae yeeo aoei 110 in?a, ui no?aaeaeaee ia IA, 103 – ia ?A oa 64 – ia IA. Eiaeio a?oio ?iciiae?eaii ua ia 4 ??aiioe?iieo i?aea?oie, caeaaeii a?ae iaoiae?a e?eoaaiiy. Aei ia?oi? a?oie aeeth/aii iaoe??io?a, eio?? iaea?aeoaaee uiaeiy 20-oaeeeii? i?ioeaaeo?e aeaeo?ioi?aco iiaiea?io; aei ae?oai? a?oie oa?eoee oaooa??, ye? iaea?aeoaaee 50% ?ic/ei aeeiaoeenoeueoieneaeo (AeINI) o aeaeyae? aie?eaoe?e o?aaeaieo noaeia?a; aei o?aouei? – oai??, yeei i?ecia/aany aeaeo?ioi?ac 4% ?ic/eio eneae?oiio (c eaoiaeo) ii 20 oaeeei eiaeai aeaiue, 20 i?ioeaaeo? ia eo?n; ?, ia?aoo?, aei /aoaa?oi? – iaoe??ioe, yeeo e?eoaaee aie?eaoe?yie 4% ?ic/eio eneae?oiio a 33% ?ic/ei? AeINI. sse aa/eii ia ?en. 3, i?e IA aeaeo?ioi?ac iiaiea?io aea? iaaiee ee?i?/iee aoaeo (a?oia IA1), ui ia? ia?aaaao iaae aeae?ioi?acii eneae?oiio (a?oia IA3). Iaoiaeii aeai?o a eieaeuei?e oa?ai?? aeaaaia?aoeaieo oai?ia noaeia?a o oaooa??a, ia iaoo aeoieo, iiaea aooe eneae?oii a ?ic/ei? AeINI (a?oia IA4). Aie?eaoe?? noaeia?a oaeith noi?ooth a?ae/ooii iioaioe?ththoue aoaeoe ?cieueiaaiiai aeei?enoiaoaaiiy AeINI (a?oia IA2), i?e/iio ?acoeueoaoe cia/ii ia?aaaaeathoue oae? a ?acoeueoao? canoinoaaiiy eneae?oiio ca aeiiiiiaith aeaeo?ioi?aco. Iacaeaaeii a?ae o?eaaeino? IA, ia?aa?ao oai?iae oa oi?ie a?o?eoo aoaeoeai?noue canoinoaaiiy eneae?oiio o ?ic/ei? AeINI aeua, i?ae o i?aea?oi? oaooa??a, ye? iaea?aeoaaee aeaeo?ioi?ac i?aia?aoo. Inoaii?e iiaeeeaee ca eaaeiai ia?aa?ao IA oa ?ioa?i?ooth/i? oi?ie oai?iae. Eneae?oii iicaaaeaiee iia?/ieo ae?e ? ia ia? i?ioeiieacaiue aei i?ecia/aiiy oai?ei ia IA, ?A oa IA o aeaeyae? eieaeueii? (a?oeeoey?ii?) oa?ai??. Aeaeo?ioi?ac eneae?oiio e?aua canoiniaoaaoe a??ieeai c iiiiie?aia?o?icii aac aoi?eiiiai neiia?oo, iaoe??ioai a aeaatho? ?aaiaoi?aeiiai aii?oo, a oaeiae a??ieeai c IA. Eneae?oii o ?ic/ei? AeINI iieacaiee on?i oaooa?yi c aeaaaia?aoeaii-caiaeueieie caoai?thaaiiyie noaeia?a ? ? iaoiaeii aeai?o o iieiaeeo a??iee?a, eio?? no?aaeaeathoue ia IA, o iaoe??io?a ia ?A c o?aaeaiiyi eie?iieo noaeia?a oa o oaooa??a c IA. I?e i?noeaaiio e?eoaaii? IA o a??iee?a aoa?eueieo oaoo aeioe?eueia eiia?iiaaia oa?ai?y o aeaeyae? aie?eaoe?e a?oaia?iio oa eneae?oiio o ?ic/ei? 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00002d010700050000000902ffffff000400000004010d00040000000201020007000000 1b041e0009011200fd00050000000902000000000400000002010100040000002e011800 0a000000320a1e000e01020000002b2b0b000b00040000002e010000040000002d010600 040000002d010700040000002d010300040000002701ffff030000001e00040000002d01 0200040000002d010700040000002d010400050000000102ffffff000500000009020000 0000070000001604250074010700f600040000002d010600040000002d01070004000000 2d010300040000002701ffff030000001e00040000002d010200040000002d0107000400 00002d010400050000000102ffffff000500000009020000000007000000160425007401 0700f60009000000fa02000001000000000000002200040000002d01080004000000f001 040007000000fc02000069ffff008020040000002d010400050000000902ffffff000500 0000010269ffff000400000004010d000400000002010200070000001b041e0039011200 2d0105000000090200000000050000000102ffffff000400000002010100040000002e01 180009000000320a1e003e01010000002b000b00040000002e010000040000002d010600 040000002d010700040000002d010300040000002701ffff030000001e00040000002d01 0200040000002d010400040000002d010800050000000102ffffff000500000009020000 0000070000001604250074010700f600040000002d010600040000002d01070004000000 2d010300040000002701ffff030000001e00040000002d010200040000002d0104000400 00002d010800050000000102ffffff000500000009020000000007000000160425007401 0700f60009000000fa02000001000000000000002200040000002d01090004000000f001 0800040000002d01050004000000f0010400050000000902ffffff000500000001020000 00000400000004010d000400000002010200070000001b041e005e011200520105000000 090200000000050000000102ffffff000400000002010100040000002e01180009000000 320a1e00630101000000b1000a00040000002e010000040000002d010600040000002d01 0700040000002d010300040000002701ffff030000001e00040000002d01020004000000 2d010500040000002d010900050000000102ffffff000500000009020000000007000000 1604250074010700f600040000002d010600040000002d010700040000002d0103000400 00002701ffff030000001e00040000002d010200040000002d010500040000002d010900 050000000102ffffff000500000009020000000007000000160459015702000000000400 00002d010500040000002d01060004000000f0010900040000002701ffff050000000c02 59015702030000001e00050000000102ffffff0005000000090200000000040000002701 ffff050000000b0200000000030000001e00050000000102ffffff000500000009020000 0000040000002701ffff030000000000 ?en. 3 Aoaeoeai?noue eieaeueii? oa?ai?? caoai?thaaiue noaeia?a (%) I?ei?oea. “++” – cia/ia iie?ioaiiy, “+” – iie?ioaiiy, “±” – aac ci?i. Ca iaoeie aeaieie, i?ecia/aiiy aiaaiceio cia/ii i?aeaeuo? ?acoeueoaoe e?eoaaeueieo caoiae?a o oaooa??a, eio?? no?aaeaeathoue ia iiaeaa?o, i?e/iio oea noino?oueny ye noaeiaiaiai, oae ? ie?eiaiai neiae?ii?a. Nenoaiia aiceiioa?ai?y ni?ey? iie?ioaiith io?eiiaiai iai?io, /iai ia a?aeaoaa?oueny a oe? ae no?iee i?ney aeei?enoaiiy caaaeueiia?aeiieo iaoiae?a e?eoaaiiy caoai?thaaiiy o?eeiaeai?anaioaie oa ianoa?i?aeieie i?ioecaiaeueieie i?aia?aoaie (IICI). Canoinoaaiiy aiaaiceio o oaei? eaoaai??? oai?eo aeeeeea? a?aeiiaeaiiy ia?aiao??a AeIO ne?iaaoee e?ia?, oei naiei i?aeoaa?aeaeoth/e ee?i?/io aoaeoeai?noue i?aia?aoo. Canoinoaaiiy O oa eiai aiaeia?a o oai?eo ia iiaeaa?o /eia i?ioecaiaeueio, o?eeiaeai?aneaio oa o?eeico?e/io ae?th, ui ca aoaeoeai?noth ia?aaeuo? a?aeii? iaoiaee e?eoaaiiy. Iieacaia uiaeiaiaa oaaaeaiiy ie?eiiai ?ic/eio O i?ioyaii aeaio oeaei?a. E?eoaaiiy oaooa??a c iao?ioe/iei neiae?iiii ? ii/aoeiaeie iciaeaie o?ii?/ii? ie?eiai? iaaeinoaoiino? ?icii/eia?oueny c i?aia?ao?a O ei?ioei? ae?? (i?ioyaii 10 aei?a) c iiaeaeueoei i?ecia/aiiyi aeaii O (oanoaiaoo, nonoaiiio, oao?anoa?iio), ye? oaiaeyoue iaeei ?ac o aeaa i?nyoe?. Eiia?iiaaia oa?ai?y (aiae?iaaie oa o?eeiaeai?ani?e) aei?aaaeaia iacaeaaeii a?ae ??aiy o?eeai?? o a??iee?a c o?ii?/iith oi?iith a?o?eoo oa o?ie?o?aciei oeiii iao?iiao??. Aeei?enoaiiy aiae?iaai?a o eiiieaeniiio e?eoaaii? oai?eo ia iiaeaa?o cia/ii i?aeaeuo? aoaeoeai?noue ?ioeo oa?aiaaoe/ieo cania?a, iie?auo? i?iaiic caoai?thaaiiy. A?aoiaoth/e ana aeuaaeeeaaeaia, iaie ?ic?iaeaii iia? i?aeoiaee aei e?eoaaiiy aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o a??iee?a aoa?eueieo oaoo. 304 a??iee?a, ianoaaeaieo o ee?i?oe?, eio?? iaea?aeoaaee o?eueee iaaeeeaiaioici? caniae, ie ?iciiae?eeee ia 5 a?oi: aei 1-i? a?oie aeeth/eee oaooa??a, ye? iaea?aeoaaee o?aaeeoe?eia e?eoaaiiy; aei 2-i? a?oie - a??iee?a, o eiiieaen e?eoaaiiy yeeo aoei aeeth/aii aiaaicei (i?ioyaii 7 aei?a – ii 5 ae?aaea o?e/? ia aeiao ca 30-40 oaeeei aei i?eeiio ?ae?; 14 aei?a – ii 4 ae?aaea o?e/? ia aeiao, i?ioyaii 1 i?nyoey – ii 3 ae?aaea o?e/? ia aeiao); aei 3-i? a?oie - yeei aeiaeaoeiai i?ecia/aany OO (a aeic? 600 ia/ ia aeiao, iacaeaaeii a?ae noaio IIE ? eiioeaio?aoe?? OO a e?ia?). 4-o a?oio neeaee oaooa??, eio?? iaeii/anii n o?aaeeoe?eiei e?eoaaiiyi iaea?aeoaaee aeiio?eiie. 5-o a?oio i?aaenoaaeyee a??ieee, yeei ii?yae ?c caaaeueiiaeciaiei e?eoaaiiyi i?ecia/aee /ieia?/? noaoaa? ai?iiie (uiaeaii? i’ycia? ?i’?eoe?? O a aeic? 1 ie 1% ?ic/eio ai?iaeiaae aeaio oeaei?a, c ianooiiei ia?aaaaeaiiyi ia i?ieiiaiaai? aeaii – oi?ie i?aia?aoo 1 ?ac o 2 i?nyoe?). Iacaai? a?oie ia ??cieeeny i?ae niaith ca a?eii, o?eaae?noth caoai?thaaiiy, aeiaiaeie aeicaie IICI, ui aeaaaei iiaeeea?noue ii??aithaaoe o ieo ?acoeueoaoe e?eoaaiiy. sseui caaaeueiia?aeii? i?aeoiaee aei e?eoaaiiy aeicaieeee aeinyaoe aoaeoo o 56,6% a??iee?a (1-a a?oia), oi a 4-e ? 5-e a?oiao oai?eo – a?aeiia?aeii o 87% ? 83% ianoaaeaieo, a a 2-e ? 3-e – a?aeiia?aeii o 96% ? 91% ianoaaeaieo oaooa??a. Oeae i?aeo?ae aeicaieea i?aeaeueoe aoaeoeai?noue ?aaa?e?oaoe?? A?IA, I?, E?, AI oa IAN. ?acii c oei aa?oi caoaaaeeoe, ui iie?ioaiiy ?acoeueoao?a oaeiai eiiieaeniiai e?eoaaiiy ca?a?no?iaaii ia i?e on?o caoai?thaaiiyo noaeia?a, a o?eueee a a?oiao oai?eo ia IA (?2 = 42,65, p>0,001), O? (?2 = 24,82, p<0,001) oa IA (?2 = 13,88, p<0,005). AENIIAEE 1. ?iciianthaeaeai?noue aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o a??iee?a ui?ieo c?inoa?, i?yii ei?aethth/e c aeaeiaooeii aoa?eey o neeaaeieo a??ie/iaaieia?/ieo oiiaao oaoo. ?ioaa?aeueiee ei?o?oe?aio caoai?thaaiino? IA c oei/aniaith ao?aoith i?aoeacaeaoiino? o oaooa??a ia?aaeuo? iieacieee o /ieia?/?e iiioeyoe?? oiai ae ?aa?iio e?a?ie a 11,8 ?aca, IA – a 31,5 ?aca, O? – a 35,8 ?aca. Noeeuei?noue a??iee?a aei ?icaeoeo iaoieia?? noaeia?a iiaeaeoaee aaiaoe/ii aeaoa?i?iiaaia. 2. Ia?aa?a IA oa a?o?eo?a o I?, A?IA, E?, IA?, IAAI a?ae??ciy?oueny a?ae oaeiai o oaooa??a aeiiii?aeieo i?ioan?e oa iaoaooa??a, ui coiiaeaii oa?aeoa?ii ae?iaie/i? ae?yeueiino? (noaoe/ieie, aeeiai?/ieie iaaaioaaeaiiyie ia I?A oa i?e?io?aaiaoecaoe??th noaeia?a a oiiaao ae?? oe?aeeeaeo oaeoi??a ?iai/i? ciie). 3. O?oaeiaa ae?yeuei?noue A?IA o?nii iia’ycaia c o?aaeaiiyi e?eoueiaeo noaeia?a, I? – iea/iaeo oa e?eoueiaeo, E? – eie?iieo, IAAI – e?eoueiaeo, eie?iieo oa aii?eeiainoiiieo, IA? – eie?iieo oa aii?eeiainoiiieo, IAN – i?iiaiaaicai’ynoeiaeo, iaeueoe?a ?oe ? ieneiainoaaiiaeo, AI – eie?iieo oa aii?eeiainoiiieo. ?icaeoie ?N oa i?ia?anoaaiiy aiia?o?ico /?oei ni?aa?aeiineoueny c? nooiaiai neeiaiai iaaaioaaeaiiy ia eie?ii? noaeiae, a oie, a naith /a?ao, c iiooaei?noth aoa?eueieo oa??a. 4. A?ae iiooaeiino? aoa?eueieo ieano?a i?e IA caeaaeaoue ae?aaeai?noue caoaeaiiy noaeiaiai? u?eeie, ?icaeoie e?aeiaeo oco? oa e?noiiiae?aieo i?ina?o?a, a a?ae aeeaeie ?ic?iaie oa eooa iaoeeo aoa?eueieo oa??a – oyaee?noue o?aaeaiiy I?A i?e O?. Nooi?iue i?ia?anoaaiiy ?A i?yii ei?aeth? c oaiia?aoo?ith ?iai/i? ciie oaoo ? iaa?iaii – c aaee/eiith aiaeii?eoie?a. 5. Niaoeeo?ea i?ioan?iiaeueii? ae?yeueiino? oaooa??a a?aeaeaa?oueny ia noai? e?i?aeiiai, io?eiiaiai oa eaeueoe??aiai iai?i?a, ?ioiiiai oa ai?iiiaeueiiai noaoon?a, iieacieeao IIE oa aioeieneaeaioieo nenoai. Oe? eaiee aiiainoaco ii?ooothoueny o oai?eo c aeaaaia?aoeaii-caiaeueieie oai?iaaie noaeia?a, ui ei?aeth? c? nooiaiai aeoeaiino? iaoieia?/iiai i?ioeano e ee?i?/iei ia?aa?aii oai?iae. IA oa a?o?eoe ia?aa?aathoue c a?ia?e?i?aeai??th, a?ia?o?eeai??th, a?ia?ia?aoe?ai?aeeciii, c? cieaeaiiyi ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a oa iaeo?io?eueieo oaaioeeo?a, i?aeaeuaiiyi ooieoe?? A-e?ioioeeo?a, iineeaiiyi IIE ia oii? i?eai?/aii? aeoeaiino? aioeieneaeaioieo nenoai. 6. Oa?aeoa? o?oaeiai? ae?yeueiino? a oaoo? ni?ey? ciaioaiith a e?ia? eiioeaio?aoe?? OeI oa c?inoaiiyi ai?noo ?2-IA. Iaoieia?y I?A noi?iaiaeaeo?oueny iiaeaeueoei cieaeaiiyi oeAIO, aea ca?eueoaiiyi oeAIO o ?ac? ia?aeaeueiiai i?aeaeuaiiy IA-A2 oa IA-F2a. Oae? c?ooaiiy OeI, i?inoaii?ae?a oa aaeaaceaiiai aenieiiieaeoey?iiai i?ioa?io aaaaoi a /iio ei?aeththoue c ??aiai ?ioiiiai aeenaaeaino. 7. Ooieoe?iiaeueia aeoeai?noue e?ioioeeo?a o oanoao c OAA oa Eii i?e oai?iaao noaeia?a o a??iee?a iaa?iaii caeaaeeoue a?ae aeeaeie oaooieo ?ic?iaie, a oeo?e a-AAA – a?ae iiooaeiino? aoa?eueieo oa??a. INA i?e IA i?yii ni?aa?aeiinyoueny c? nooiaiai oaooieo aiaeii?eoie?a. C iaaaoeaieie a??ie/iaaieia?/ieie oiiaaie oaoo iia’ycaia ae?aaeai?noue iaoaaie?/ieo ?iceaaeiaiue oa IIE. 8. A iaoiaaiac? i?ioan?eiiai IA o oaooa??a aa?ooue o/anoue noaeeii? ?iceaaeiaiiy c ii?ooaiiyi e?iaiia?ao a a?oeeoey?ieo oeaieiao, a?ia?i?iaeoeoe?y i?icaiaeueieo e?ciniiieo oa?iaio?a oa ?2-IA, eio?? ei?aeththoue c? nooiaiai aeoeaiino? caoai?thaaiiy, aea ia caeaaeaoue a?ae i?ioan?? a??iee?a. 9. ?ioaa?aeueieie iieacieeaie ci?i a?eeiai-e?i?aeieo no?oaeoaio?a ? IA? o a?ieia?/ieo ??aeeiao oai?eo oaooa??a ? ia?aiao?e aeeiai?/ii? iaaeoacii? oaic?iiao??? e?ia? oa na/?. Noai II caeaaeeoue a?ae a??ie/iaaieia?/ieo oiia oaoo. Iieacieee i?aeoacii? oaic?iiao??? aecia/athoueny iicieia?/iith oi?iith oai?iae noaeia?a oa i?ioan??th ?ia?oiee?a, ui aeicaiey? aeei?enoiaoaaoe oeae iaoiae aeine?aeaeaiiy aeey ae?aaiinoeee IA ? a?o?eo?a o a??iee?a. 10. O I?, IAAI, IAN oa AI e?eoaaiiy IA caaaeaee iio?aao? canoinoaaiiy caaaeueieo iaaeeeaiaioicieo oaeoi??a, a o A?IA oa E? ii/anoe aeinoaoiuei eieaeueii? (a?oeeoey?ii?) oa?ai??. O A?IA e?eoaaiiy iiaeiia aooe ni?yiiaaia ia e?eoueia? noaeiae, o I? – ia e?eoueia? oa iea/ia?, o E? – ia eie?ii?, o IA? oa AI – ia eie?ii? oa aii?eeiainoiii?, o IAAI – ia eie?ii?, aii?eeiainoiii? oa e?eoueia?, o IAN – ia i?iiaiaaicai’ynoeia?, iaeueoe?a ?oe ? ieneiainoaaiia?. sseui o A?IA oa IAAI eieaeueio oa?ai?th iaiao?aeii cae?enithaaoe iaeii/anii ia neiao?e/i? noaeiae, a ?aaa?e?oaoe?ei? caoiaee e?aua aeeiioaaoe i?ney ?iaioe a oaoo?, oi e?eoaaiiy oai?ia I?A o IA? oa E? aaaeaii aeeiioaaoe aei ?iai/i? ci?ie, e?aua a ?aieiaee /an. 11. I?eoaiaii? ia eeoa oai?ei, a e caei?iaei a??ieeai ii?ooaiiy e?i?aeiiai, io?eiiaiai oa eaeueoe??aiai iai?i?a, IIE oa aioeieneaeaioieo nenoai, ?ioiiiai ? ai?iiiaeueiiai noaoon?a, iio?aaothoue aeei?enoaiiy a a?naiae? e?eoaaeueieo caoiae?a i?e IA oa a?o?eoao eiiieaeniooai?thth/eo i?aia?ao?a (eneae?oiio), oiiae?ii?ioaeoi??a (aeoeooiio oa ?io.), o?eeiii?iae?coth/eo cania?a (aeiio?eiieo oa ?io.), aiae?iaai?a (O oa ?io.), aioeieneaeaio?a (OO oa ?io.) oa cania?a nenoaiii? aiceiioa?ai?? (aiaaicei oa ?io.). 12. Aoaeoeai?noue iaaeeeaiaioicii? oa?ai?? noaeiaiaeo oai?ia caeaaeeoue a?ae oaoo oaooa??a, a ?acoeueoaoe aeei?enoaiiy i?aoi?iiaaieo o?ce/ieo oaeoi??a – a?ae iicieia?/ii? oi?ie caoai?thaaiiy. Iaee?aueo ?acoeueoao?a ?aaa?e?oaoe?? oai?eo ia IA aeinyaathoue o aoaey??a, eio?? ?ic?iaeythoue iiooaei? aoa?euei? oa?e. 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Ii?oieia?y oiiae?ieaeueoeeiico // Oace aeiiia?aeae V Eiia?ano iaoieiaiaiaoii?a Oe?a?ie “Aeieia?/ia oa ?ioaeoe?eia iaoieia?y: no/ani? iaoieiaiaiaoii?/i? aniaeoe”. – *a?i?a?a. – 1993. – N. 155-156. 33. Iooei E.A., Oea/aiei E.E., Neiy/aiei I.A., Aioiiia A.A., Oaa?iai A.A., Eaiaoaiei A.A., Caeeoianeay E.E. Eciaiaiey nenoaiu aeiioec-aiiaaeu i?e iiaeaa?a e yenia?eiaioaeueiie aeia?o?eeaiee // Oacenu aeieeaaeia iao/ii-i?aeoe/aneie eiioa?aioeee “Nia?aiaiiua i?iaeaiu eeeie/aneie yiaeie?eiieiaee”. – Oa?ueeia. – 1993. – N. 39-40. 34. Eaiaoaiei A.A., Aioiiia A.A., Neiy/aiei I.A., Oaa?iai A.A., Ao?aiia I.A., Aiai/aiei I.TH. Ninoiyiea eiioieoaoa o ?aai/eo aeoaieeo oaoo Aeiiaanna // Iaoa??aee aeiiia?aeae ?anioae?eainueei? iaoeiai? eiioa?aioe?? “Aeooaeuei? ieoaiiy aeiaaiaoeee oa ?ioiieia??”. – Ee?a. – 1994. – N. 56. 35. Eaiaoaiei A.A. ?ani?ino?aiaiiinoue aeaaaia?aoeaiuo, ainiaeeoaeueiuo, iaoaaiee/aneeo e iiooieaauo caaieaaaiee iii?ii-aeaeaaoaeueiiai aiia?aoa a Aeiiaoeeie iaeanoe // Oacenu aeieeaaeia thaeeaeiie iao/iie eiioa?aioeee, iinayuaiiie i?io. E.A. Caaai?iaeiaio. – Aeiiaoee. – 1994. – *.2. – N. 10-11. 36. Eaiaoaiei A.A. Iniaaiiinoe oa/aiey ainiaeeoaeueiuo caaieaaaiee nonoaaia o ?aai/eo oaieueiuo oaoo // Iaoa?eaeu thaeeaeiie iao/ii-i?aeoe/aneie eiioa?aioeee “Aeooaeueiua i?iaeaiu i?ioanneiiaeueiie iaoieiaee e ?aaeeaoeeiiiie iaaeeoeeiu”. – Aeiiaoee. – 1994. – N. 72. 37. Neiy/aiei I.A., Ieeieaiei I.E., Iooei E.A., Eaiaoaiei A.A. Ii?oieiae/aneea eciaiaiey a nonoaaao i?e yenia?eiaioaeueiie iiaeaa?a // Oace aeiiia?aeae I iaoe?iiaeueiiai eiia?ano aiaoii?a, a?noieia?a, yia??ieia?a oa oiiia?aoiaiaoii?a Oe?a?ie “Aeooaeuei? ieoaiiy ii?oieia??”. – ?aaii-O?aie?anuee. – 1994. – N. 159-160. 38. Neiy/aiei I.A., Aa?eiia Y.O., Eaiaoaiei A.A., Aioiiia A.A., ?oaeiaa A.N., O?enooeaiei A.E. Oaeoi?u ?enea e oa/aiea aeaaaia?aoeaii-ainiaeeoaeueiuo caaieaaaiee o ai?ii?aai/eo oaieueiuo oaoo // Oacenu aeieeaaeia Anaoe?aeineie eiioa?aioeee n iaaeaeoia?iaeiui o/anoeai “Aeooaeueiua aii?inu aeaeaiu o?oaea, i?ioiaoieiaee e iaaeeoeeineiai iaania/aiey o?oaeyueony i?iiuoeaiiuo i?aaei?eyoee ia nia?aiaiiii yoaia ?acaeoey oicyenoaaiiiai eiiieaena Aeiiaanna”. – Aeiiaoee. – 1995. – N. 218. 39. Aa?eiia ?.O., Neiy/aiei I.A., Aioiiia A.A., Eaiaoaiei A.A., A?iieaaaa I.A., Aeue Ianna? N.A., O?enooeaiei A.E. Iaoaieci aeaenoaey eieaeueiie e?eioa?aiee caaieaaaiee nonoaaia // Oace aeiiia?aeae ? c’?caeo Oe?a?inueeiai oiaa?enoaa e??ia?ieia?? ? e??iiaaeeoeeie. – Oa?e?a. – 1995. – N. 11-12. 40. Aa?eiia Y.O., ?oaeiaa A.N., Eaiaoaiei A.A., A?iieaaaa I.A., Caeeoianeay E.E., O?enooeaiei A.E., Aeue-Oaaaaeao I.I. I iaoiaaiaca i?ioanneiiaeueiuo caaieaaaiee nonoaaia // Iaoa?eaeu ?anioaeeeaineiai neiiiceoia “Aeooaeueiua aii?inu ?aaiaoieiaee”. – Iaeanna. – 1995. – N. 15-16. 41. Eaiaoaiei A.A. Ei??aeoeey ia?ooaiee io?eiiaiai iaiaia o oaooa?ia-oaieueueeia, no?aaeathueo ainiaeeoaeueiuie caaieaaaieyie nonoaaia // Oacenu aeieeaaeia iao/iie eiioa?aioeee “Aeooaeueiua i?iaeaiu iaaeeoeeiu Aeiiaanna”. – Aeiiaoee. – 1996. – N. 58-59. 42. Neiy/aiei I.A., Aa?eiia A.O., Eaiaoaiei A.A., Oaaei?/aiei I.A., Aioiiia A.A., O?enooeaiei A.E., Aiai/aiei I.TH., Caeeoianeay E.E. Inoaia?o?ic o ai?ii?aai/eo oaieueiuo oaoo // Iaoa??aee aeiiia?aeae iaoeiai? eiioa?aioe?? “Aeooaeuei? ieoaiiy oai?aoe/ii? oa ee?i?/ii? iaaeeoeeie ia no/aniiio ??ai?”. – Iieoaaa. – 1996. – N. 367-368. 43. Aiai/aiei I.TH., Oienoie A.A., O?enooeaiei A.E., Aioiiia A.I., Eaiaoaiei A.A., Aeue Ianna? N.A. Ii?ooaiiy io?eiiaiai iai?io oa ?o ei?aeoe?y i?e aeaaaia?aoeaii-caiaeueieo caoai?thaaiiyo noaeia?a o oaooa??a // Oace aeiiia?aeae iaoeiai-i?aeoe/ii? eiioa?aioe?? ?aaiaoieia?a Oe?a?ie “No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”. – Aeiiaoeuee. – 1996. – N. 3-4. 44. Oaaei?/aiei I.A., Aiai/aiei I.A., Caeeoianeay E.E., Eaiaoaiei A.A., Aioiiia A.A., Ua?aaeia E.N. Oaeoi?u ?enea aieaciae nonoaaia o ai?ii?aai/eo oaieueiuo oaoo // Oace aeiiia?aeae iaoeiai-i?aeoe/ii? eiioa?aioe?? ?aaiaoieia?a Oe?a?ie “No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”. – Aeiiaoeuee. – 1996. – N. 54. 45. ?aiaoaiei A.A. Oai?iaa ?aeoa?a o oaooa??a // Iaoa??aee ?? Iaoe?iiaeueiiai Eiia?ano ?aaiaoieia?a Oe?a?ie. – Ee?a. – 1997. – N. 92. AIIOAOe?ssAIIOAOe?ss ?aiaoaiei A.A. Aeaaaia?aoeaii-caiaeuei? caoai?thaaiiy noaeia?a o oaooa??a (?iciianthaeaeai?noue, iniaeeaino? ia?aa?ao, ae?aaiinoeea, ieoaiiy iaoiaaiaco, e?eoaaiiy). - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.12 – ?aaiaoieia?y. – ?inoeooo ea?ae?ieia?? ?i. aeaae. I.Ae. No?aaeanea AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?th i?enay/aii aea/aiith ?iciianthaeaeaiino? inoaia?o?ico, iiaeaa?e/iiai ? ?aaiaoi?aeiiai a?o?eo?a, oai?ia ?aeoa?a oa A?oo???aa o i?io?aeiee?a, a??iee?a i/eniiai aeaith, e??ieeueiee?a, i?aecaiieo a??iee?a, iaoei?no?a a??ie/iae?iieo iaoei, i?aecaiieo aeaeo?inethna??a, i?ae?eaiee?a, a??ie/eo iaeno??a ia oaooao c ??cieie a??ie/iaaieia?/ieie oiiaaie. Aecia/aii cia/aiiy aaiaoe/ieo oaeoi??a o noeeueiino? aei aeaaaia?aoeaii-caiaeueieo caoai?thaaiue noaeia?a o oaooa??a. Ioe?iaii ee?i?ei-?aioaaiieia?/iee ia?aa?a ie?aieo caoai?thaaiue iii?ii-?ooiaiai aia?aoo o ?ia?oiee?a ??cieo i?ioan?e caeaaeii a?ae oiia ?o i?aoe?. Aeiaaaeaii ?ieue e?i?aeiiai, io?eiiaiai oa eaeueoe??aiai iai?i?a, ai?iiiaeueiiai noaoono, iieaciee?a ia?aeeniiai ieeneaiiy e?i?ae?a ? aioeieneaeaioieo nenoai, ?2-i?e?iaeiaoe?io, oeeee?/ieo ioeeaioeae?a, i?inoaaeaiaeei?a A2 ? F2?, ci?i ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a ? iaeo?io?e?a, iieaciee?a niaoeeo?/iiai ?ioi?oaoo a iaoiaaiac? inoaia?o?ica ? ??cieo a?o?eo?a o a??iee?a aoa?eueieo oaoo. I?iaeaiiino?iaaii cia/aiiy aeeiai?/ii? i?aeoacii? oaic?iiao??? ne?iaaoee e?ia?, na/? ? neiia?aeueii? ??aeeie aeey ae?aaiinoeee caoai?thaaiue ? ioe?iee aoaeoeaiino? ?o e?eoaaiiy. Ioe?iaii aoaeoeai?noue caaaeueiia?aeiieo ?aaa?e?oaoe?eieo caoiae?a i?e iaoieia?? noaeia?a o oaooa??a ? ?ic?iaeaii iiao oaoiieia?th iaaeeeaiaioicii? oa?ai?? oaei? eaoaai??? oai?eo. Eeth/ia? neiaa: caoai?thaaiiy noaeia?a, oaooa??, ?iciianthaeaeai?noue, ae?aaiinoeea, iaoiaaiac, e?eoaaiiy. SUMMARY G.A.Ignatenko. Degenerative-and-inflammatory Diseases of the Joints in Miners. (Prevalence, Course Features, Diagnosis, Problems of Pathogenesis, Treatment). – A manuscript. The dissertation submitted for the M.D. degree in speciality 14.01.12 – rheumatology. - The M.D.Straghesko Institute of Cardiology. Academy of Medical Siences of Ukraine, Kyiv, 1999. The dissertation is devoted to the study of the prevalence of osteoarthrosis, gouty and rheumatoid arthritis, Reiter“s and Bekhterev“s diseases among drift has been, working face miners, timbermen, underground miners, combined machine operators, underground electricians, powdermen, formen and at mines with different mine geological conditions. The importance of genetic factors in susceptibility to degenerative-and-inflammatory diseases of the joints has been determined. The clinicoroengenologic course of some diseases of the locomotor system in workers various professions depending on their working conditions has been assessed. The role of lipid, purine and calcium metabolism, hormonal status, values of lipid peroxidation and antioxidant systems, ?2-microglobulin, cyclic nucleotides, prostaglandins E2 and F2?, changes of the functional activity of lymphocytes and neutrophils, specific immunity indices in the pathogenesis of osteoarthrosis and various arthritis in miners has been proved. The importance of dynamic interphase tensiometry of blood, urine and synovial fluid for both the diagnosis of the diseases assessment of their treatment has been demonstrated. The efficacy of known rehabilitative measures in articular pathology of miners has been assessed. A new technology of medicinal therapy of such a category of patients has been developed. Key words: diseases of the joints, miners, prevalence, diagnosis, pathogenesis, treatment. AIIIOAOeEss Eaiaoaiei A.A. Aeaaaia?aoeaii-ainiaeeoaeueiua caaieaaaiey nonoaaia o oaooa?ia (?ani?ino?aiaiiinoue, iniaaiiinoe oa/aiey, aeeaaiinoeea, aii?inu iaoiaaiaca, ea/aiea). - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.12 - ?aaiaoieiaey. - Einoeooo ea?aeeieiaee ei. aeaae. I.Ae. No?aaeanei AII Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia eco/aieth ?ani?ino?aiaiiinoe inoaia?o?ica (IA), iiaeaa?e/aneiai (IA) e ?aaiaoieaeiiai a?o?eoa (?A), aieaciae ?aeoa?a (A?) e Aaooa?aaa (AA) o i?ioiae/eeia (I?), ai?ii?aai/eo i/enoiuo caaiaa (A?IC), e?aieeueueeia (E?), iiaecaiiuo ai?ii?aai/eo (IA?), iaoeienoia ai?iiauaii/iuo iaoei (IAAI), iiaecaiiuo yeaeo?ineana?ae (IYN), ac?uaieeia e ai?iuo ianoa?ia (AI) ia oaooao n ?aciuie ai?iiaaieiae/aneeie oneiaeyie (aeoaeiie ?ac?aaioie, oaiia?aoo?ie ?aai/ae ciiu, iiuiinoueth e oaeii iaaeaiey oaieueiuo ieanoia, aeeeiie caaiaa, aaee/eiie ioiineoaeueiuo e aaniethoiuo aiaeii?eoieia. Eioaa?aeueiue eiyooeoeeaio caaieaaaaiinoe IA n a?aiaiiie oo?aoie o?oaeiniiniaiinoe o oaooa?ia i?aauoaao iieacaoaee a ioaeneie iiioeyoeee a 11,8 ?aca, IA - a 31,5 ?aca, A? - a 35,8 ?aca. I?ioanneiiaeueiue IA ano?a/aaony o 1/3 ai?ii?aai/eo e ia aai aeieth i?eoiaeeony 4/5 io anao aieaciae iii?ii-aeaeaaoaeueiiai aiia?aoa (IAeA). Ii?aaeaeaii cia/aiea aaiaoe/aneeo ia?ea?ia (a?oii e?iae, ?acon-oaeoi?a e eaeeioeeoa?iuo aioeaaiia) a neeiiiinoe e aeaaaia?aoeaii-ainiaeeoaeueiui caaieaaaieyi nonoaaia o oaooa?ia. Ioeaiaiu eeeie/aneia oa/aiea e ?aioaaiieiae/aneea i?eciaee ioaeaeueiuo caaieaaaiee IAeA o ?aai/eo ?aciuo i?ioannee a caaeneiinoe io oneiaee eo o?oaea. Oa/aiea IA e a?o?eoia o I?, A?IC, E?, IA? e IAAI ioee/aaony io oaeiaiai o oaooa?ia aniiiiaaoaeueiuo i?ioannee e iaoaooa?ia, /oi iaoneiaeaii noaoe/aneeie e aeeiaie/aneeie ia?aa?oceaie IAeA, a oaeaea iee?io?aaiaoecaoeeae nonoaaia a oneiaeyo aeaenoaey a?aaeiuo oaeoi?ia ?aai/ae ciiu. O?oaeiaay aeayoaeueiinoue A?IC oanii naycaia n ii?aaeaieai eieoaauo nonoaaia, I? - iea/aauo e eieoaauo, E? - eieaiiuo, IAAI - eieoaauo, eieaiiuo e aieaiinoiiiuo, IA? - eieaiiuo e aieaiinoiiiuo, IYN - eo/acaiynoiuo, iaeueoeaa ?oe e oaciaaae?aiiuo, AI - eieaiiuo e aieaiinoiiiuo. ?acaeoea ?aaeoeaiiai neiiaeoa e i?ia?anne?iaaiea aiia?o?ica /aoei niioiineony ni noaiaiueth neeiaie iaa?ocee ia eieaiiua nonoaau, a oa - n iiuiinoueth oaieueiuo ieanoia. Aeieacaii ?ieue eeieaeiiai, io?eiiaiai e eaeueoeeaaiai iaiaiia, ai?iiiaeueiiai noaoona, iieacaoaeae ia?aeeniiai ieeneaiey eeieaeia e aioeieneaeaioiuo nenoai, oeeeee/aneeo ioeeaioeaeia, i?inoaiieaeia, eciaiaiee eiioiiiai aiiainoaca a iaoiaaiaca IA e ?acee/iuo a?o?eoia o ai?ii?aai/eo oaieueiuo oaoo. Eco/ai o?iaaiue iauaai oieanoa?eia, ?-oieanoa?eia, o?eaeeoea?eaeia, eeiii?ioaeaeia aunieie, ieceie e i/aiue ieceie ieioiinoe, enaioeiieneaeacu, ii/aaie eeneiou e eo eee?ainia, iauaai e eiiece?iaaiiiai eaeueoeey, ia?aoe?eia, eaeueoeeoiieia, eaeueoeeo?eiea, oanoinoa?iia, i?iaanoa?iia, yno?aaeeiea, oieeo?iieia, etho?iieia, aeeaiiauo eiiuthaao, iaeiiiaiai aeeaeueaeaaeaea, noia?ieneaeaeeniooacu, ?-oieioa?iea, ?2-iee?iaeiaoeeia, oeeeee/aneiai aaeaiiceiiiiioinoaoa e aoaiiceiiiiioinoaoa, i?inoaaeaiaeeiia A2 e F2?, O-eeioioeeoia (oaeia?ia e noi?anni?ia), A-eeioioeeoia, aioeoae e oeaiyi neiiaeaeueiie iaiei/ee e o?yua, aeeeicaieiiaeeeaiai, iaoeaiie e aeaiaoo?e?iaaiiie AeIE, oaaioeeoa?iie aeoeaiinoe iaeo?ioeeia, ooieoeeiiaeueiie aeoeaiinoe eeioioeeoia a oanoao n oeoiaaiaaaethoeieiii e eiieaiaaaeeiii. Iineaaeiyy i?e aieaciyo nonoaaia o ai?iyeia ia?aoii caaeneo io aeoaeiu oaooiuo ?ac?aaioie, a oeo?u aioeoae e aeeeicaieiiaeeeaiai - io iiuiinoe oaieueiuo ieanoia. I?ioeaineiiaeaeueiua aioeoaea i?e IA i?yii niioiinyony ni noaiaiueth oaooiuo aiaeii?eoieia. N iaaaoeaiuie ai?iiaaieiae/aneeie oneiaeyie oaoo naycaia au?aaeaiiinoue iaoaaiee/aneeo ?anno?ienoa e ia?aeeniiai ieeneaiey eeieaeia. A iaoiaaiaca i?ioanneiiaeueiiai IA o oaooa?ia i?eieiatho o/anoea ninoaeenoua ?anno?ienoaa n ia?ooaieai e?iainiaaaeaiey a a?oeeoey?iuo oeaiyo, /oi ei??aee?oao ni noaiaiueth aeoeaiinoe caaieaaaiey, ii ia caaeneo io i?ioannee ai?iyeia. I?iaeaiiino?e?iaaii cia/aiea ia?aiao?ia aeeiaie/aneie iaaeoaciie oaiceiiao?ee e?iae, ii/e e neiiaeaeueiie aeeaeeinoe aeey iieacaoaeae iiaa?oiinoiiai iaoyaeaiey i?e a?aiaiao ?aaiuo 0,01 nae. e 1 nae., a oaeaea niioaaonoaothuaio ?aaiiaaneth aeey aeeaaiinoeee caaieaaaiee eieiiioi?iiai aiia?aoa e ioeaiee yooaeoeaiinoe eo ea/aiey. Ninoiyiea aeeiaie/aneiai iiaa?oiinoiiai iaoyaeaiey e?iae caaeneo io ai?iiaaieiae/aneeo oneiaee oaoo e ii?aaeaeyaony iicieiae/aneie oi?iie aieaciae nonoaaia e i?ioanneae ?aai/eo. Ioeaiaia yooaeoeaiinoue iauaecaanoiuo ?aaaeeeoaoeeiiiuo ia?ii?eyoee i?e ioaeaeueiuo aeaaaia?aoeaii-ainiaeeoaeueiuo caaieaaaieyo nonoaaia o oaooa?ia iniiaiuo e aniiiiaaoaeueiuo i?ioannee. Iainiiaaiu oeaeaniia?aciinoue i?eiaiaiey eiiieaeniia?acothueo i?aia?aoia (eneaeeoiia), oiiae?ii?ioaeoi?ia (aeoeooiia e ae?.), o?eeiii?iaeecothueo n?aaenoa (aeeiio?eiiea e ae?.), aiae?iaaiia (oanoinoa?iia e ae?.), aioeieneaeaioia (oieioa?iea e ae?.) e nenoaiiie yiceiioa?aiee (aiaaiceia e ae?.) n o/aoii iniaaiiinoae iaoiaaiaca caaieaaaiee o oaeeo aieueiuo. Yooaeoeaiinoue iaaeeeaiaioiciie oa?aiee nonoaaiuo aieaciae caaeneo io niaoeeaeueiinoe oaooa?ia, a ?acoeueoaou eniieueciaaiey i?aoi?ie?iaaiiuo oece/aneeo oaeoi?ia - io iicieiae/aneie oi?iu caaieaaaiey. Iaeeo/oeo ?acoeueoaoia ?aaaeeeoaoeee aieueiuo IA iiaeii aeinoe/ue o oaieueueeia, ?ac?aaaouaathueo iiuiua oaieueiua ieanou. Oeaeaiai?aaeaiiua eiiieaeniua ?aaaeeeoaoeeiiiua ia?ii?eyoey o ai?ii?aai/eo n aeaaaia?aoeaii-ainiaeeoaeueiie iaoieiaeae IAeA iicaieyao iiauneoue ?acoeueoaou a ioaeaeueiuo i?ioanneiiaeueiuo a?oiiao ia 30-40%. Eeth/aaua neiaa: caaieaaaiey nonoaaia, oaooa?u, ?ani?ino?aiaiiinoue, aeeaaiinoeea, iaoiaaiac, ea/aiea. IA?AE?E OIIAIEO NEI?I*AIUe a-AAA aioeo?ea aei ae?eicai?iiae?eai?a AI a??ie/? iaeno?e A?IA a??ie/? ?ia?oieee i/enieo aeai?a Eii eiieaiaaae?i -A E? e??ieeueieee IAAI iaoei?noe a??ie/iae?iieo iaoei IA inoaia?o?ic I?A iii?ii-?ooiaee aia?ao IA iiaeaa?e/iee a?o?eo IA? iiaa?oiaai-aeoeai? ?a/iaeie IA i?inoaaeaiaeei IA? i?aecaii? a??ie/? ?ia?oieee IAN i?aecaii? aeaeo?inethna?? II iiaa?oiaaee iaoya IIE ia?aeenia ieeneaiiy e?i?ae?a I? i?io?aeieee INA i?ioeneiia?aeuei? aioeo?ea ?A ?aaiaoi?aeiee a?o?eo ?N ?aaeoeaiee neiia?o O oanoinoa?ii OO ?-oieioa?ie OAA o?oiaaiaaethoei?i OA oai?iaa A?oo???aa O? oai?iaa ?aeoa?a oeAIO oeeee?/iee aaeaiiceiiiiioinoao oeAIO oeeee?/iee aoaieiiiiioinoao OeI oeeee?/i? ioeeaioeaee ?2-IA ?2-i?e?iaeiaoe?i Caeaii a iaa?? 22.03.1999 ?. I?aeienaii aei ae?oeo 23.03.1999 ?. Oi?iao 90o60 1/16 Ianya 2,0 oiiai. ae?oe. a?e. Oe?aae 100 i?ei. Caiia. ?360. Iaae?oeiaaii c i?ea?iae-iaeaoa a AO “Aeaeaaieoeoai “Aeiia//eia” 340118, i. Aeiiaoeuee, Ee?anueeee i?iniaeo, 48

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