?aai/ay a?oiia ii ea/aieth eioa?eoa ieiea?aea
Aa?iiaeneiai iauanoaa ea?aeeieiaia
Ino?ue eioa?eo ieiea?aea:
aeinoaoeeiia?iia e noaoeeiia?iia ea/aiea
OTHIAIUe 1997
IIENAIEA INO?IAI EIOA?EOA IEIEA?AeA
Nai? aiaiiaca i?e ino?ii eioa?eoa ieiea?aea auaaao cao?oaeiai ii ?yaeo
i?e/ei: oe?ieia ?ani?ino?aiaiea eioa?eoa ni neaaiau?aaeaiiuie
neiioiiaie, /anoioa nia?oaeueiuo neo/aaa io ino?ie ei?iia?iie
iaaeinoaoi/iinoe aia aieueieoeu e aa?uee?iaaiea niiniaia aeeaaiinoeee. A
?aaioao, i?iaiaeeiuo /eaiaie Iauanoaa, eiinoaoe?iaaeinue, /oi iauee
eaoaeueiue enoiae i?e ino?uo na?aea/iuo i?enooiao a ia?aue ianyoe
ninoaaeyao ieiei 50%, a n?aaee yoeo nia?oae iieiaeia neo/aaony a ia?aua
2 /ana. Oaeay aunieay nia?oiinoue neaaea oiaiueoeeanue ca iineaaeiea 30
eao. Ii eiio?anoo ni nia?oiinoueth aia aieueieoeu iaaethaeaaony
cia/eoaeueiia nieaeaiea eaoaeueiinoe n?aaee oao, eoi ea/eeny a
aieueieoea. Aei nicaeaiey ioaeaeaiee eioaineaiie oa?aiee aeey aieueiuo n
ino?ie ei?iia?iie iaaeinoaoi/iinoueth a 1960-o, nia?oiinoue a
noaoeeiia?a, a n?aaeiai, ninoaaeyea ieiei 25-30% E. Iaci? ?aaio ii
nia?oiinoe a aeio?iiaieeoe/aneoth y?o iieacae, /oi n?aaeiyy nia?oiinoue
a na?aaeeia 1980-o aiaeia ninoaaeyea 18%. Iauay nia?oiinoue ca ianyoe, n
oao ii?, nieceeanue, ii ana aua inoaaony aunieie, ianiio?y ia oe?ieia
eniieueciaaiea o?iiaieeoe/aneeo i?aia?aoia e anie?eia. Oae, a iaaeaaiai
enneaaeiaaiee MONICA (iiieoi?eia iai?aaeaiee e ii?aaeaeythueo oaeoi?ia
na?aea/ii-ninoaeenouo caaieaaaiee) iyoe e?oiiuo ai?iaeia nia?oiinoue ca
28 aeiae ninoaaeea 13-27%. A ae?oaeo ?aaioao niiauaaony i iany/iie
nia?oiinoe a i?aaeaeao 10-20% .
Iiiai eao iacaae auei onoaiiaeaii, /oi ioaeaeueiua i?eciaee yaeythony
i?aaeaanoieeaie nia?oe iaoeeaioia, aeinoaaeaiiuo a aieueieoeo n
eioa?eoii ieiea?aea E. Aeaaiuie n?aaee ieo yaeythony aic?ano,
i?aaeoanoaiaaaoea caaieaaaiey (aeeaaao, ia?aianaiiue eioa?eo),
iaoe?iinoue eioa?eoa, aeeth/ay aai ianoiiieiaeaiea (ia?aaeiee eee
ieaeiee), ieceia enoiaeiia e?iayiia aeaaeaiea, iaee/ea canoiy a iaeii
e?oaa e?iaiia?auaiey e ?ani?ino?aiaiea eoaiee, auyaeaiiie ia
yeaeo?iea?aeeia?aiia ii iiieaeaieth e/eee iiauoaieth ST. Yoe oaeoi?u
inoathony aeaenoaaiiuie e naaiaeiy.
OeAEE EA*AIEss
A oi a?aiy eae ia?aiia/aeueiay caaioa oa?aiaaoia caeeth/aaony a
i?aaeioa?auaiee eaoaeueiiai enoiaea, ?aaioa oao, eoi ooaaeeaaao ca
aea?oaaie eioa?eoa ieiea?aea iaoeaeaia ia nieaeaiea aei ieieioia
aeeneiioi?oa e iaaeiiiaaiey iaoeeaioia, a oaeaea ia ia?aie/aiea
?ani?ino?aiaiey iia?aaeaeaiey ieiea?aea. Aeey oaeianoaa eo?n ea/aiey
iiaeao auoue ?acaeaeai ia o?e oacu:
(1) Iaioeiaeiay iiiiuue, eiaaea iniiaiua oneeey iai?aaeaiu ia nieaeaiea
aiee e i?aaeioa?auaiea eee ea/aiea inoaiiaee na?aeoea.
(2) ?aiiaa ea/aiea, ai a?aiy eioi?iai iniiaiia aieiaiea iai?aaeaii ia
i?iaaaeaiea ?aia?ooceiiiie oa?aiee n oeaeueth ia?aie/aiey ciiu eioa?eoa,
a oaeaea ea/aiea aicieeoeo ineiaeiaiee a aeaea iaaeinoaoi/iinoe ianiniie
ooieoeee na?aeoea, oiea e iianiuo aeey aeecie a?eoiee.
(3) Iineaaeothuaa ea/aiea, iai?aaeaiiia ia i?aaeioa?auaiea ianooiathueo
iau/ii iicaea ineiaeiaiee, a iniiaiia aieiaiea oaeaeyaony
i?aaeoi?aaeaeaieth aicieeiiaaiey iiaiai eioa?eoa e nia?oe.
Yoe oacu iiaoo niioaaonoaiaaoue aeinoaoeeiia?iiio ea/aieth, ea/aieth a
ioaeaeaiee eioaineaiie oa?aiee aeey aieueiuo n ino?ie ei?iia?iie
iaaeinoaoi/iinoueth (aeie eioaineaiie oa?aiee) e i?aauaaieth a iaeaoa
iinea aeiea eioaineaiie oa?aiee, ii iie iiaoo a cia/eoaeueiie ia?a
ia?aieaoaoueny, oae /oi i?aaei?eiyoia aeaeaiea ia eaoaai?ee yaeyaony
eneonnoaaiiui.
IAIOEIAEIAss IIIIUUe
IA*AEUeIUE AeEAAIIC
Nia/aea neaaeoao iinoaaeoue ?aai/ee aeeaaiic eioa?eoa ieiea?aea. Iau/ii
ii iniiauaaaony ia iaee/ee neeueiie aiee a a?oaeiie iaeanoe,
i?iaeieaeathuaeny 15 e aieaa ieioo, iaeoie?othuaeny ieo?iaeeoea?eiii.
Iaeiaei, aieue iiaeao auoue e ia i/aiue neeueiie, iniaaiii o iiaeeeuo
ethaeae; ae?oaea i?eciaee, oaeea eae iaeuoea, aieiaie?oaeaiea eee
iaii?ie oe?iei ?ani?ino?aiaiu. Aaaeiuie e?eoa?eyie yaeythony
i?aaeoanoaiaaaoay eoaie/aneay aieaciue na?aeoea, a oaeaea e??aaeeaoeey
aiee a oath, ieaeithth /aethnoue eee eaaoth ?oeo. Ia nouanoaoao
eiaeeaeaeoaeueiuo oece/aneeo i?eciaeia aeey aeeaaiinoeee eioa?eoa
ieiea?aea, ii o aieueoeinoaa iaoeeaioia au?aaeaia aeoeaaoeey
aaaaoaoeaiie ia?aiie nenoaiu (aeaaeiinoue, iioiioaeaeaiea), a oaeaea
eeai aeiioaicey, eeai nieaeaiiia ioeueniaia a?oa?eaeueiia aeaaeaiea.
Neiioiiu iiaoo oaeaea aeeth/aoue a?eoieth, a?aaeeea?aeeth eee
oaoeea?aeeth, 3 oii na?aeoea e aacaeueiua o?eiu. Yeaeo?iea?aeeia?aiio
neaaeoao niyoue eae iiaeii nei?aa. Aeaaea ia ?aiiae noaaeee YEA i/aiue
?aaeei auaaao ii?iaeueiie. Oai ia iaiaa, a ia?aua /anu YEA /anoi iayniay
e aeaaea i?e iiaeoaa?aeaeaiiii eioa?eoa iiaeao ia iieacaoue eeanne/aneea
i?eciaee iiauoaiey ST e iiyaeaiey coaoeia Q. Neaaeoao naeaeaoue
iiaoi?iua caiene YEA e, ii aiciiaeiinoe, n?aaieoue eo ni naeaeaiiuie
?aiaa. Iiieoi?e?iaaiea YEA neaaeoao ia/aoue eae iiaeii nei?aa o anao
aieueiuo aeey iaia?oaeaiey oa?iaeathueo aeecie a?eoiee. Anee aeeaaiic
iaoiaeeony iiae niiiaieai, aaaeii i?iaanoe auno?ue oano ia?ea?ia
nuai?ioee e?iae. A o?oaeiuo neo/ayo iiaoo iiii/ue yoiea?aeeia?aoey e
aiaeia?aoey.
EOIE?IAAIEA AIEE, IAeUOEE E NO?AOA
Eoie?iaaiea aiee eiaao ia?ainoaiaiiia cia/aiea ia oieueei ec /enoi
/aeiaa/aneeo niia?aaeaiee, a iioiio, /oi aieue nii?iaiaeaeaaony
neiiaoe/aneei aicaoaeaeaieai, eioi?ia aucuaaao noaeaiea e?iaaiiniuo
ninoaeia e oneeeaaao ?aaioo na?aeoea. A yoii neo/aa aioo?eninoaeenoua
ia?eioe/aneea i?aia?aou – ii?oei eee, oai, aaea anoue aiciiaeiinoue,
aeeaii?oei – yaeythony iaeaieaa ?ani?ino?aiaiiuie aiaeueaaoeeaie;
aioo?eiuoa/iuo eiuaeoeee neaaeoao ecaaaaoue. Aiciiaeii iiiaaeiayony
iiaoi?iua aeicu. Iiai/iua yooaeou caeeth/athony a iiyaeaiee oioiiou e
?aiou, aeiioaicee n a?aaeeea?aeeae, a oaeaea a oaiaoaiee aeuoaiey.
I?ioeai?aioiua n?aaenoaa iiaoo iacia/aoueny iaeiia?aiaiii n ia?eioeeaie.
Aeiioaicey e a?aaeeea?aeey iau/ii /oanoaeoaeueiu e ao?iieio, a oaiaoaiea
aeuoaiey e iaeieniio, eioi?iai anaaaea aeieaeii auoue a aeinoaoea a
aieueieoea. Anee ia?eioeee ia nieaeatho aieue iinea iaiaeiie?aoiiai
i?eiaiaiey, a yoii neo/aa i/aiue yooaeoeaiu aioo?eaaiiua aaoa-aeieaoi?u
eee ieo?aou. A ?anii?yaeaiee ia?aiaaeeeia eiaaony ia?aie/aiiue auai? ia
aucuaathueo i?eaueaiey ia?eioeeia, eniieueciaaiea aa?uee?oao a ?aciuo
no?aiao. Eenei?iae iacia/aaony niaoeeaeueii oai, o eiai iaaethaeaaony
iaeuoea, eiathony i?eciaee na?aea/iie iaaeinoaoi/iinoe eee oie.
No?ao – anoanoaaiiay ?aaeoeey ia aieue e ianoiyoaeuenoaa, ie?oaeathuea
na?aea/iue i?enooi. Oniieaeaaiea aieueiuo e oao, eoi iaoiaeeony ?yaeii n
ieie, eiaao aaaeiia cia/aiea. Anee aieueiie noaiiaeony /?acau/aeii
aaniieieiui, iiaeii iacia/eoue o?aieaeeecaoi?, ii /aua anaai
ia?eioe/aneeo n?aaenoa aiieia aeinoaoi/ii.
INOAIIAEA NA?AeOeA.
Iniiau aeeciaiaania/aiey
Oai, eoi ia iao/ai eee ia eiaao niioaaonoaothuae aiia?aoo?u aeey
ieacaiey eaaeeoeoee?iaaiiie iaaeeoeeineie iiiiue, neaaeoao ia/aoue
auiieiyoue iniiaiua i?aaeea iaania/aiey aeecie /aeiaaea,
?aeiiaiaeiaaiiua Aa?iiaeneei niaaoii ii ?aaieiaoeee.
I?ia?anneaiay oaoiieiaey aeeciaiaania/aiey
Iao/aiiua ia?aiaaeeee e ae?oaea i?ioanneiiaeu aeieaeiu ieacaoue
ea/anoaaiioth iiiiuue a niioaaonoaee n ?aeiiaiaeaoeeyie Aa?iiaeneiai
niaaoa ii ?aaieiaoeee.
?AIIEE YOAI EA*AIEss
AINNOAAEAIEA E IIAeAeA?AEAIEA I?IOIAeEIINOE EIOA?EO-NAssCAIIIE A?OA?EE.
Aieueiui n eeeie/aneeie i?iyaeaieyie eioa?eoa ieiea?aea e iiauoaieai ST
eee aeieaaeie io/ea Aena aeieaeia auoue i?iaaaeaia ?aiiyy ?aia?oocey.
O?iiaieeoe/aneia ea/aiea
Aeieacaoaeuenoai iieaciinoe. Aieaa 100 000 aieueiuo aoiaeeee a ninoaa
a?oii aeey enneaaeiaaiey i?eiaiaiey o?iiaieeoe/aneeo n?aaenoa e
n?aaieoaeueiiai eco/aiey iaeiie no?aoaaee ea/aiey o?iiaieeoeeaie n
ae?oaie. Aeieacaia ni anae i/aaeaeiinoueth iieueca io aaaaeaiey aieueiui
o?iiaieeoe/aneeo n?aaenoa a oa/aiea 12 /ania n iiiaioa iiyaeaiey
neiioiiia eioa?eoa.
Ec 1000 aieueiuo, eiio a oa/aiea 6 /ania n iiiaioa iiyaeaiey neiioiiia e
iiauoaiey ST eee iaee/ey aeieaaeu io/ea Aena aaaee o?iiaieeoeee. auei
nianaii, i?eaeeceoaeueii, 30 /aeiaae; ec oao, eoi iieo/ee ea/aiea a
i?iiaaeooea io 7 aei 12 /ania, auee nianaiu 20 /aeiaae ia 1000 aieueiuo.
Ia eiaaony oaaaeeoaeueiuo aeieacaoaeuenoa iieaciinoe ea/aiey ii
i?ioanoaee 12 /ania aeey anae a?oiiu a oeaeii.
?aaioa, i?iaaaeaiiay ISIS-2, iieacaea aaaeiinoue aeiiieieoaeueiiai
i?eiaiaiey anie?eia, /oi iiiiaei nianoe, i?eaeeceoaeueii, 50 aeeciae ia
1000 aieueiuo, iieo/eaoeo ea/aiea. I?ineaaeeaaaony iinoiyinoai
iieiaeeoaeueiiai aicaeaenoaey eae i?e n?aaiaiee a?oii i?aaeaa?eoaeueii
no?aoeoeoee?iaaiiuo aieueiuo, oae e i?e aiaeeca aeaiiuo, iieo/aiiuo
aioo?e iiaea?oii. Iaeaieueoee, aaniethoiue iieiaeeoaeueiue ?acoeueoao
iaaethaeaaony n?aaee iaoeeaioia ec a?oiiu iaeaieueoaai ?enea, aeaaea
anee a i?iii?oeeiiaeueiii au?aaeaiee ?acoeueoao iiaeao auoue
iaeeiaeiaui. Oae, aieueoaa /enei aeeciae nianaaony a ?an/aoa ia 1000
aieueiuo ec a?oiiu n iiauoaiiui ?eneii; iai?eia?, oao, /ae aic?ano
i?aauoaao- 65 eao. oao, o eiai nenoiee/aneia aeaaeaiea 180 mm Hg)
Eaca?iay oa?aiey nao/aoee, i?iaaaeaiiay iaaeaaii
Niiniau i?eiaiaiey Oaaeeoea 1.
Noaia i?eiaiaiey o?iiaieeoe/aneeo n?aaenoa i?e eioa?eoa ieiea?aea
Ia/aeueiia ea/aiea
I?eiaiaiea aaia?eia Iniaua i?ioeaiiieacaiey
No?aioieeiaca (NE)
1,5 iei. aae.
100 ie 5% aeaeno?icu eee 0,9% oec.?-?a ieiei 30-60 iei Iao eee
iiaeeiaeii 12 500 A.ae. 2 ?. a aeaiue.
I?aaeoanoaothuee
(>5 aeiae) i?eai NE/aieno?aieacu
Aieno?aieaca
30 aae. ca 3-5 iei a/a
I?aaeoanoaothuee i?eai NE eee aieno?aieacu > 5 aeiae.
Auyaeaiiay aeea?ae/aneay ?aaeoeey ia NE/aieno?aieaco.
Aeueoaieaca ( t PA)
15 ia a/a aiethn 0,75 ia. ea-1 ieiei 30 iei., caoai 0,5 ia. ea-1
ieiei 60iei. a/a.
Iauay aeica ia aeieaeia i?aauoaoue 100 ia. a/a a oa/aiea 48 /an*
O?ieeiaca**
2 iei. Aae a ea/anoaa a/a aiethna eee 1,5 iei. aae. aiethn + 1,5
iei. aae. a oa/aiea 1 /ana. a\a a oa/aiea 48 /an*
A aeaiiie oaaeeoea i?eaaaeaiu iaeaieaa /anoi oiio?aaeyaiua noaiu ia/aiey
o?iiaieeoeeaie . Ae?oaea noaiu e iiaua n?aaenoaa iiaoo eiaoue
i?aeiouanoaa iaae aeaiiuie noaiaie, ii aiciiaeiua i?aeiouanoaa ia auee
iienaiu a ?aaioao.
* Aeice?iaea eiio?iee?oaony ii?aaeaeaieai A *OA.
** A ioaeaeueiuo ainoaea?noaao ia eeoeaice?iaai a ea/anoaa i?aia?aoa,
i?eiaiyaiiai aeey ea/aiey eioa?eoa ieiea?aea. N.B. Anie?ei neaaeoao
aeaaaoue anai iaoeeaioai aac i?ioeaiiieacaiee.
Iiaoi?iia iacia/aiea o?iiaieeoe/aneeo n?aaenoa. Anee eiaaony
iiaeoaa?aeaeaiea iiaoi?iie ieeethcee eee ?aoeeaeeaa eioa?eoa n iiauoaiey
ST eee aeieaaeie io/ea Aena, neaaeoao iacia/eoue aeaeueiaeooth
o?iiaieeoe/aneoth oa?aieth eee ?anniio?aoue aii?in i ieanoe/aneie
iia?aoeee ia ninoaeao. No?aioieeiaco e aieno?aieaco iaeuecy iacia/aoue n
i?iiaaeooeii a 5 aeiae e ieieioi /a?ac 2 aiaea iinea ia?aiia/aeueiiai
ea/aiey ethaui ec oeacaiiuo i?aia?aoia. Aioeoaea e no?aioieeiaca
nio?aiytho onoie/eainoue ieieioi 2 aiaea ia o?iaia, aeinoaoi/iii aeey
ia?ooaiey aeoeaiinoe i?aia?aoa. A ?acoeueoaoa i?eaia aeueoaieacu (t-PA)
e o?ieeiacu aioeoaea ia au?aaaouaathony.
Aeiiieieoaeueiua aioeo?iiaioe/aneea e aioeo?iiaioeeoa?iua ea/aaiua
.ia?ii?eyoey. Iacaaeneiay aeiiieieoaeueiay iieueca anie?eia iienuaaeanue
?aiaa. Ia nianai ynii, aeaenoaoao ee anie?ei, oneeeaay o?iiaieecen,
i?aaeioa?auay iiaoi?ioth ieeethceth, eee ia?aie/eaay aicaeaenoaea
aeoeaaoeee o?iiaioeeoia ia iee?ioee?eoeyoeeth. A ?aaioao, iinayuaiiuo
iicaeiae ?aieeethcee, anie?ei ieacaeny aieaa yooaeoeaiui i?e
i?ioeeaeoeea ?aoeeaeeae?othuaai oa/aiey caaieaaaiey, /ai a
iiaeaea?aeaiee i?ioiaeeiinoe ninoaeia. Ia?aiia/aeueiay aeica 150-160 ia
ia?i?aeueii, a caoai oaeay aea aeica aeaaony aaeaaeiaaii.
Aaia?ei oe?iei i?eiaiyaony iinea o?iiaieecena, iniaaiii aianoa n
aeoeaaoi?ii ieacieiiaaia. Aaia?ei ia oeo/oaao iaiaaeeaiii oea?eiieec ,
iaeiaei ieacaeinue, /oi i?ioiaeeiinoue ninoaeia iiauoaaony a /anu eee
aeie, neaaeothuea ca o?iiaieeoe/aneie oa?aieae aeoeaaoi?ii ieacieiiaaia,
eo/oa anaai i?e aioo?eaaiiii aaaaeaiee aaia?eia . ?acieoea a
i?ioiaeeiinoe ia iaaethaeaeanue o iaoeeaioia, i?eieiaaoeo eeai
iiaeeiaeii, eeai aioo?eaaiii aaia?ei e no?aioieeiaco. I?ieiiae?iaaiiia
aioo?eaaiiia iacia/aiea aaia?eia ia i?aiyonoaoao ?aieeethcee iinea
iiaeoaa?aeaeaiey n ii iiuueth aiaeia?aoee oniaoiiai ei?iia?iiai
o?iiaieecena, oae aea eae e aioo?eaaiii ( aaaaeaiea aaia?eia, ca eioi?ui
i?eieiaaony eoiaaeei. Aeeaaiea aaia?eia iinea oa?aiee aeoeaaoi?ii
ieacieiiaaia iiaeii ioiaieoue ii i?ioanoaee 24-48 /ania.
I?aaeii/oeoaeueii i?iaiaeeoue iiieoi?eia ea/aiey aaia?eiii; cia/aiea
A*OA nauoa 9N naeoiae niioiinyo n iainii?eiui ?eneii aicieeiiaaiey
oea?aa?aeueiiai e?iaioa/aiey. A eniuoaieyo ISIS-3 aaiaeeiue iiaeeiaeii
aaia?ei (12500 Aae. 2 ?aca a aeaiue) ia ieacuaae aeeyiey ia nia?oiinoue
i?e niaaeeiaiee n anie?eiii e no?aioieeiacie, aeuethoaieacie eee
aieno?aieacie.
*?aneiaeiay o?ainethieiaeueiay ei?iia?iay aiaeiieanoeea (*OEA). ?ieue
ei?iia?iie aiaeiieanoeee a oa/aiea ia?auo /ania ?acaeoey eioa?eoa
ieiea?aea iiaeii ?acaeaeeoue ia ia?ae/ioth aiaeiieanoeeo, aiaeiieanoeeo,
niaaeeiaiioth n ea/aieai o?iiaieeoe/aneeie n?aaenoaaie e
“nianeoaeueioth” (“rescue”) aiaeiieanoeeo iinea iaoaea/iiai ea/aiey
o?iiaieeoeeaie.
Ia?ae/iay aiaeiieanoeea. Oae iacuaaaony aiaeiieanoeea aac
i?aaeaa?eoaeueiie eee niioonoaothuae o?iiaieeoe/aneie oa?aiee e
i?eiaiyaony oieueei a neo/aa auno?iai aeinooia ( 2 e . iei -1 Iiaeii aeaoue iiieaeaiiua aeicu aeiiaieia 2,5 (g. kg -1 .
min -1 aeey oeo/oaiey ooieoeee ii/ae, a oaeaea neaaeoao i?aaeoniio?aoue
aeiiieieoaeueiia iacia/aiea aeiaooaieia 5-10(g. kg -1 . min -1.
Aieueiua a ea?aeeiaaiiii oiea n/eoathony aoeeaeioe/iuie. Ei??aeoeey
aoeeaeica aaaeia, oae eae eaoaoieaieiu ieacuaatho neaaue yooaeo a eeneie
n?aaea.
N?i/iay *OEA eee iia?aoeey iiaoo iiiaaeiaeoueny aeey nianaiey aeecie
aieueiiai e neaaeoao i?aaeoniio?aoue eo ia ?aiiae noaaeee.
Iiaeaea?aeeaathuaa ea/aiea n iiiiuueth iaaiaoaoaeueiiai aaeeiia
(eiio?ioeuenaoeey) yaeyaony aaaeiui ia?aoiaeiui iiiaioii e oaeiio
aiaoaoaeuenoao.
?AC?UA NA?AeOeA E ?AAO?AEOAOeEss E?IAE I?E IAAeINOAOI*IINOE IEO?AEUeIIAI
EEAIAIA. ?AC?UA NOAIEE (IA?AAI?IAeEE)
Ineiaeiaiea ano?a/aaony a 1-3% anao ainieoaeece?iaaiiuo aieueiuo n
ino?ui eioa?eoii ieiea?aea. Ec ieo 30-50% neo/aaa i?ienoiaeeo a ia?aua
24 /ana e 80- 90% a ia?aua 2 iaaeaee.
Ino?ay oi?ia. Iia oa?aeoa?ecoaony eieeainii n yeaeo?iiaoaie/aneie
aeennioeeaoeeae, o.a. iai?a?uaiie yeaeo?e/aneie aeoeaiinoueth n iioa?ae
na?aea/iiai aua?ina e ioeuena. A oa/aiea ianeieueeeo ieioo ianooiaao
nia?oue, aieueiie ia ?aaae?oao ia iau/iua ia?u ainnoaiiaeaiey na?aea/iie
aeayoaeueiinoe e aeuoaiey. Oieueei a ?aaeeeo neo/ayo oaeaaony
aeinoaaeoue iaoeeaioa a iia?aoeeiiioth.
Iiaeino?ay oi?ia. I?eaeeceoaeueii a 25% neo/aaa iaaieueoea ii?oeee e?iae
aeinoeaatho iieinoe ia?eea?aea e nicaeatho i?ia?anne?othuoth
aaiiaeeiaie/aneoth iaa?oceo. Eeeie/aneay ea?oeia iiaeao eieoe?iaaoue
iiaoi?iue eioa?eo, ec-ca aiciaiiaeaiey aieae e iiaoi?iiai iiaeuaia
naaiaioa ST, iaeiaei /aua neo/aaony aiacaiiia oooaeoaiea aaiiaeeiaieee n
a?aiaiiie eee aeeeoaeueiie aeiioaiceae. Iiyaeythony eeanne/aneea
neiioiiu oaiiiiaaeu na?aeoea, /oi iiaeao auoue iiaeoaa?aeaeaii
yoiea?aeeia?aoeae. Neaaeoao ?aoeoueny ia iaiaaeeaiioth iia?aoeeth,
iacaaeneii io eeeie/aneiai ninoiyiey aieueiiai, oae eae a aieueoeinoaa
neo/aaa aeaeaa neaaeoao ino?ay oi?ia.
Iia?aoeey auiieiyaony ii aanoiaiie oaoiieiaee, iienaiiie Iaae?i e ae?.,
i?e eioi?ie ia o?aaoaony aiia?ao eneonnoaaiiiai e?iaiia?auaiey.
AeAOAEO IAAEAEAEOAeI*EIAIE IA?AAI?IAeEE
Aeaoaeo iaaeaeaeoaei/eiaie ia?aai?iaeee (IAEI) ia?acoaony ii/oe oaco
iinea ia/aea eioa?eoa ieiea?aea, /anoioa iiyaeaiey ninoaaeyao 1-2% ec
iauaai /enea eioa?eoia. Aac oe?o?ae/aneiai aiaoaoaeuenoaa nia?oiinoue a
oa/aiea ia?aie iaaeaee ninoaaeyao 54%, a a oa/aiea ia?aiai aiaea -92%.
Aeeaaiic, nia/aea i?aaeiieaaaaiue ec-ca neeueiiai nenoiee/aneiai ooia a
aeaea io?eueaiuey, nii?iaiaeaeaaiiai ?aceei eeeie/aneei oooaeoaieai,
iiaeoaa?aeaeaaony yoiea?aeeia?aoeae e/eee iaia?oaeaieai iinooieaiey
eenei?iaea a i?aaue aeaeoaei/ae. Io?eueathuee ooi, oai ia iaiaa, iiaeao
auoue ia i/aiue a?iieei eee aiana ionoonoaiaaoue. Oa?iaeieiae/aneia
ea/aiea ninoaei?anoe?ythueie n?aaenoaaie, oaeeie eae ieo?iaeeoea?ei
aioo?eaaiii, iiaoo i?eianoe iaeioi?ia iaeaa/aiea a neo/aa, anee iao
ea?aeeiaaiiiai oiea, ii naiui yooaeoeaiui niiniaii, iaania/eaathuei
aniiiiaaoaeueiia e?iaiia?auaiea ai a?aiy iiaeaioiaee e iia?aoeee,
yaeyaony aioo?eai?oaeueiay aaeeiiiay eiio?ioeuenaoeey. Iia?aoeey
yaeyaony aaeeinoaaiiui oainii aeey auaeeaaiey i?e iaoe?iuo
iinoeioa?eoiuo aeaoaeoao IAEI n ea?aeeiaaiiui oieii. Ia?aiia/aeueiay
oeaeue ?aiiaai i?iaaaeaiey iia?aoeee caeeth/aaony a iaaeaaeiii cae?uoee
aeaoaeoa n eniieueciaaieai oaoieee iaeiaeaiey “caieaou”. Neaaeoao
i?iaanoe i?aaeiia?aoeeiiioth ei?iia?ioth aiaeia?aoeth i?e oneiaee, /oi
iia ia i?ioeaiiieacaia ii aaiiaeeiaie/aneiio ninoiyieth eee ia auciaao
iaii?aaaeaiioth ion?i/eo iia?aoeee. I?e iaiaoiaeeiinoe aeaeatho
iaoiaeiia ooioe?iaaiea. I?aaeneacaoaeyie iaaeaaiiieo/iiai ?acoeueoaoa
iia?aoeee yaeythony ea?aeeiaaiiue oie, caaeiaa ?aniieiaeaiea aeaoaeoa,
aeenooieoeey i?aaiai aeaeoaei/ea, aic?ano aieueiiai e a?aiy ion?i/ee
iia?aoeee iinea ?ac?uaa ia?aai?iaeee.. Aieueie/iay nia?oiinoue iinea
iia?aoeee ioeaieaaaony io 25 aei 60%, a 95% auaeeaoeo eiatho 1-2
ooieoeeiiaeueiue eeann o?iie/aneie na?aea/iie iaaeinoaoi/iinoe ii NYHA .
?AAO?AEOAOeEss E?IAE I?E IAAeINOAOI*IINOE IEO?AEUeIIAI EEAIAIA
Aieueoeinoai neo/aaa ?aao?aeoaoeee e?iae i?e iaaeinoaoi/iinoe
ieo?aeueiiai eeaiaia iinea eioa?eoa ieiea?aea au?aaeaiu oia?aiii,
?aoethen auaaao i?aoiaeyuei. Iaeiaei, o iaiueoae /anoe aieueiuo
au?aaeaiiay ?aao?aeoaoeey yaeyaony na?ueaciui ineiaeiaieai, i?e eioi?ii
o?aaothony eioaineaiua iaoiaeu ea/aiey, anee auno?i iinoaaeai aeeaaiic e
aeieaeii auoue i?aaei?eiyoi oe?o?ae/aneia ea/aiea. *anoioa aicieeiiaaiey
oia?aiii oyaeaeie e oyaeaeie oi?i ?aao?aeoaoeee ninoaaeyao ieiei 4%, a
nia?oiinoue aac oe?o?ae/aneiai aiaoaoaeuenoaa aaeeea: ieiei 24%. Iau/ii
iia ni/aoaaony ni cia/eoaeueiui noaeaieai eae i?aaie, oae e eaaie
iaeaathuae ei?iia?iuo a?oa?ee n ii?aaeaieai ieaeiaiaaeeaeueiie
iaieeey?iie iuooeu.
Ea?aeeiaaiiue oie e ioae eaaeeo n oyaeaeie oi?iie ?aao?aeoaoeee e?iae
i?e iaaeinoaoi/iinoe ieo?aeueiiai eeaiaia o?aaoao iaiaaeeaiiie
iia?aoeee. ?aciauaiea ianina-aaeeiia aioo?e ai?ou iiaeao ieacaoue
iiiiuue a ia?eiae iiaeaioiaee. Ei?iia?iay aiaeia?aoey i?iaiaeeony a oii
neo/aa, anee iicaieyao ninoiyiea iaoeeaioa. I?e canoieiie na?aea/iie
iaaeinoaoi/iinoe iiaeii i?aaei?eiyoue ia?ae/ioth eaoaoa?ecaoeeth e
?aia?ooceth eioa?eo-naycaiiie a?oa?ee n iiiiuueth o?iiaieecena eee *OEA.
Caiaia eeaiaia yaeyaony iia?aoeeae auai?a i?e aeenooieoeee iaieeey?iie
iuooeu e ?ac?uaa, ii iiaeao auoue i?aaei?eiyoa oieueei a ioaeaeueiuo
neo/ayo. ?aaaneoey?ecaoeey iieacaia i?e iiiaeanoaaiiie iano?oeoeee
iniiaiuo ninoaeia. A?eoiee e ia?ooaiey i?iaiaeeiinoe
A?eoiee e ia?ooaiey i?iaiaeeiinoe /?acau/aeii ?ani?ino?aiaiu a ia?aua
/anu eioa?eoa ieiea?aea. A ioaeaeueiuo neo/ayo, oaeeo eae aeaeoaei/eiaay
oaoeea?aeey e oea?eeeyoeey aeaeoaei/eia, iie oa?iaeatho aeecie aieueiiai
e o?aaotho iaiaaeeaiiie ei??aeoeee. Iaeiaei, /anoi a?eoiee naie ii naaa
ia iianiu, ii iie yaeythony i?eciaeii na?ueaciuo ne?uouo ?anno?ienoa,
iai?eia? i?iaeieaeeoaeueiie eoaiee, aaaoniiai ia?aiai?yaeaiey eee
yeaeo?ieeoiuo ia?ooaiee, eioi?ua o?aaotho iniaiai aieiaiey.
Iaiaoiaeeiinoue ea/aiey e n?i/iinoue , a iniiaiii, caaeneo io
aaiiaeeiaie/aneeo iineaaenoaee ?anno?ienoaa ?eoia.
AEAEOAeI*EIAUA A?EOIEE
AEaeoaei/eiaua yeoiie/aneea ?eoiu. AEaeoaei/eiaua ?eoiu ii/oe anaaaea
oieaa?naeueiu a ia?aue aeaiue, /anoi i?enoonoaoao eiiieaen a?eoiee
(iiiaiia?aciua eiiieaenu, e?aoeia?aiaiiua i?iaaaeee aeaeoaei/eiaie
oaoeea?aeee eee oaiiiai R-ia-O). Eo cia/eiinoue a ea/anoaa i?eciaeia
oea?eeeyoeee aeaeoaei/eia nii?ia; eeai aeaeoaei/eiaay oea?eeeyoeey
neaaeoao oae auno?i, /oi iaaiciiaeii i?eiyoue i?ioeeaeoe/aneea ia?u,
eeai ia neaaeoao na?ueaciuo a?eoiee.
AEaeoaei/eiaay ia?ieneciaeueiay oaoeea?aeey. Ei?ioeea i?iaaaeee
aeaeoaei/eiaie oaoeea?aeee iiaoo oi?ioi ia?aiineoueny e ia o?aaotho
ea/aiey, iaeiaei aieaa i?iaeieaeeoaeueiua neo/ae iiaoo’ aucaaoue
aeiioaiceth e na?aea/ioth iaaeinoaoi/iinoue. Eeaeieaei – aio oi
eaea?noai, eioi?ia auae?aaony a ia?aoth i/a?aaeue, iaeiaei, anoue e
ianeieueei ae?oaeo eaea?noaaiiuo n?aaenoa, eioi?ua oaeaea iiaoo
ieacaoueny yooaeoeaiuie. Iau/ii aeaaony ia/aeueiay aeica eeaeieaeia 1
ia. ea-1 aioo?eaaiii, iieiaeia yoie aeicu iiaoi?yaony eaaeaeua 8-10
ieioo, aeioiaey aei iaeneiaeueiie, eioi?ay ninoaaeyao 4 ia. ea-1. Ca iae
iiaeao neaaeiaaoue aioo?eaaiiia aeeaaiea aeey i?aaeioa?auaiey
?aoeeaeeaa. Yeaeo?ieiioeueniay oa?aiey iieacaia, anee aaiiaeeiaie/anee
cia/eiay aeaeoaei/eiaay oaoeea?aeey inoaaony onoie/eaie.
Aaaeii ioee/eoue enoeiioth aeaeoaei/eiaoth oaoeea?aeeth io onei?aiiiai
eaeeiaaio?eeoey?iiai ?eoia, iau/ii aaca?aaeiiai iineaaenoaey ?aia?oocee,
i?e eioi?ii aeaeoaei/eiaue ?eoi auaaao ieaea 120 oaea?ia. iei.
Oea?eeeyoeey aeaeoaei/eia. Anee anoue aeaoea?eeeyoi?, neaaeoao i?iaanoe
aeaoea?eeeyoeeth. Anee aai iao, oiaaea noieo iaianoe ?aceee oaea? ii
ieaeiae o?aoe a?oaeeiu. Neaaeoeoa ?aeiiaiaeaoeeyi Aa?iiaeneiai iauanoaa
ii ?aaieiaoeee (?en. 1 ).
NOI?AAAIO?EEOEss?IUA A?EOIEE
Ia?oeaoaeueiay a?eoiey yaeyaony ineiaeiaieai a 15-20% neo/ayo eioa?eoa
ieiea?aea e /anoi ni/aoaaony n na?ueaciui iia?aaeaeaieai eaaiai
aeaeoaei/ea e na?aea/iie iaaeinoaoi/iinoueth. Iau/ii iia naiinoiyoaeueii
eoie?oaony. A ?aciuo neo/ayo iia iiaeao aeeeoueny io ianeieueeeo /ania
aei ianeieueeeo ieioo, i/aiue /anoi n ?aoeeaeeaaie. Ai iiiaeo neo/ayo
aeaeoaei/eiaue ?eoi ia i/aiue auno?ue, a?eoiey oi?ioi ia?aiineony, ia
o?aaoaony ea/aiey. A inoaeueiuo neo/ayo auno?ue ?eoi niinianoaoao
na?aea/iie iaaeinoaoi/iinoe e o?aaoao iacaiaaeeeoaeueiiai ea/aiey.
Aeeaienei yooaeoeaai aeey nieaeaiey ?eoia ai iiiaeo neo/ayo, iaeiaei
aieiaea?ii iiaeao ieacaoueny aieaa yooaeoeaiui aeey i?ae?auaiey a?eoiee
. Iiaeii oaeaea eniieueciaaoue yeaeo?ieiioeuenioth oa?aieth, ii aa
neaaeoao i?iaiaeeoue auai?i/ii, oieueei a neo/aa, anee ?aoeeaeeau
o/auathony.
Ae?oaea oi?iu noi?aaaio?eeoey?iuo a?eoiee ano?a/athony ?aaeei e iau/ii
naiinoiyoaeueii eoie?othony. Iie iiaoo ?aaae?iaaoue i?e iaaeaaeeaaiee ia
ea?ioeaeiue neion. Iiaoo ieacaoueny yooaeoeaiuie aaoa-aeieaoi?u, anee
iao- i?ioeaiiieacaiee, iaeiaei aa?aiaiee ia ?aeiiaiaeoaony. Anee a?eoiey
ieioi ia?aiineony, neaaeoao iii?iaiaaoue yeaeo?ieiioeuenioth oa?aieth.
NEIONIAAss A?AAeEEA?AeEss E AEIEAAeA NA?AeOeA
Neioniaay a?aaeeea?aeey /anoi ano?a/aaony a ia?aue /an, iniaaiii i?e
ieaeiai eioa?eoa ieiea?aea. A ioaeaeueiuo neo/ayo a ?acoeueoaoa
aeaenoaey ia?eioe/aneeo n?aaenoa. Iia iiaeao nii?iaiaeaeaoueny oyaeaeie
oi?iie aeiioaicee, a yoii neo/aa neaaeoao i?eiaiyoue ao?iiei
aioo?eaaiii, ia/eiay n 0,3-0,5 ia, iiaoi?yy aei aaaaeaiey iauae aeicu
1,5-2,0 ia. Iicaea, i?e ea/aiee eioa?eoa ieiea?aea, iia yaeyaony
aeaaii?eyoiui i?eciaeii e ia o?aaoao ea/aiey. Eiiaaea iia, oai ia iaiaa,
iiaeao ni/aoaoueny n aeiioaiceae. Anee ia aoaeao ?aaeoeee ia ao?iiei,
oiaaea iiaeii iiniaaoiaaoue e?aoeia?aiaiioth yeaeo?iea?aeeinoeioeyoeeth.
?en. 1. ?aeiiaiaeaoeee Aa?iiaeneiai iauanoaa ?aaieiaoeee ii ea/aieth
oea?eeiyoeee aeaeoaei/eia.
OEA?EEEssOeEss AEAEOAeI*EIA EEE AEAEOAeI*EIAAess
IA?IENECIAEUeIAss OAOEEA?AeEss I?E IONOONAEE IOEUeNA
I?aea?aeeaeueiue oaea?
Aeaoea?eeeyoeey 200 J (1)
Aeaoea?eeeyoeey 200 J (2)
Aeaoea?eeeyoeey 360 J (3)
Anee ia iiiiaei:
eiooaaoeey
a/a aeinooi
Aae?aiaeei 1 ia a/a
10 na?ee na?aea/ii-eaai/iie ?aaieiaoeee ec 5:1 eiii?anney/aaioeeyoeey
Aeaoea?eeeyoeey 360 J (4)
Aeaoea?eeeyoeey 360 J (5)
Aeaoea?eeeyoeey 360 J (6)
Eioa?aae iaaeaeo 3 e 4 aeaoea?eeeyoeeyie ia aeieaeai auoue > 2 ieioo.
Iiaoi?iua aaaaeaiey aae?aiaeeia /a?ac eaaeaeua 2-3 ieioou. Iiaoi?iua
aeaenoaey i?iecaiaeyo oae aeieai, iiea iieacaia aeaoea?eeeyoeey. Iinea
3-o e?aoiuo aeaenoaee 3-6:
•n?aaenoai aeey iuaea/eaaiey ?I e?iae
•i?ioeaia?eoie/aneia n?aaenoai
Ia?aay noaiaiue aeieaaeu na?aeoea ia ioaeaeaaony a ea/aiee.
Aoi?ay noaiaiue: oei I (Aaieaaao) AA (ao?eiaaio?eeoey?iie) aeieaaeu
iau/ii ni/aoaaony n ieaeiei eioa?eoii ieiea?aea e ?aaeei aucuaaao
iiai/iua aaiiaeeiaie/aneea yooaeou. Oai ia iaiaa, anee oae neo/eeinue,
nia/aea ioaeii aeaoue ao?iiei; anee ii ia iiiia, iacia/atho
yeaeo?inoeioeyoeeth.
Aoi?ay noaiaiue: oei II (Iiaeoe) e iieiay AA aeieaaea neoaeao
iieacaieyie e aaaaeaieth yeaeo?iaeia. Yeaeo?inoeioeyoeeth neaaeoao
i?aaei?eiyoue, anee iaaethaeaaony caiaaeeaiiay /anoioa na?aea/iuo
nie?auaiee, /oi iiaeao aucaaoue aeiioaiceth eee na?aea/ioth
iaaeinoaoi/iinoue. Anee aaiiaeeiaie/aneia ia?ooaiea iineo na?ueaciue
oa?aeoa?, neaaeoao i?aaeoniio?aoue iai?a?uaioth yeaeo?inoeioeyoeeth.
Anenoieey iiaeao iineaaeiaaoue ca AA aeieaaeie, aeaoo- eee o?aoio/eiaie
aeieaaeie eee yeaeo?ieiioeueniie oa?aieae. Anee yeaeo?iae iaoiaeeony ia
ianoa, neaaeoao i?aaei?eiyoue yeaeo?inoeioeyoeeth. Eee aea neaaeoao
iii?iaiaaoue eiii?anneth e aaioeeyoeeth a?oaeiie eeaoee e ia/aoue
aiaoithth yeaeo?inoeioeyoeeth. O?ainaaiiciue yeaeo?iae neaaeoao
aaiaeeoue, eae iienuaaeinue ?aiaa, i?e iaee/ee i?ia?anne?othuae
aio?eiaaio?eeoey?iie aeieaaeu, a oaeaea ii?aaeaeeoue ?acaeaaaony aeaoo –
eee o?aoio/eiaay aeieaaea. Iiiaea ea?aeeieiae ioaeatho i?aaeii/oaiea
iiaeeeth/e/iiio aeinooio, ii aai neaaeoao ecaaaaoue i?e i?iaaaeaiee
o?iiaieecena eee aioeeiaaoeyioiie oa?aiee. Ae?oaea o/anoee auae?athony
ii neooaoeee.
I?IOEEAEOE*ANEAss OA?AIEss A INO?IE OACA
Anie?ei. Oaaaeeoaeueiia aeieacaoaeuenoai yooaeoeaiinoe anie?eia auei
i?iaeaiiino?e?iaaii a enneaaeiaaiee ISIS-2, a eioi?ii iieacaee, /oi
iaaethaeaaony aeiiieieoaeueiue yooaeo io i?eiaiaiey anie?eia e
no?aioieeiacu. A yoii enneaaeiaaiee aieaa 17 000 iaoeeaioia
ia?aiia/aeueii i?eiyee 160 ia anie?eia a oaaeaoeao, caoai aaeaaeiaaii
i?iaeaouaaee iaeio 160 ia oaaeaoeo. Nia?oiinoue n?aaee oao, eoi i?eieiae
anie?ei a ISIS-2, ninoaaeea 9,4°/i, ii n?aaiaieth n 11,8%, i?eieiaaoeo
ieaoeaai. Yooaeoeaiinoue iaaethaeaeanue eae n?aaee oao, eoi iieo/ae, oae
e oao, eoi ia iieo/ae o?iiaieeoe/aneea n?aaenoaa. I?e iaci?a anao
enneaaeiaaiee n anie?eiii i?ineaaeeaaeinue aeiiieieoaeueiia nieaeaiea
nia?oiinoe ia 29% , i?e nia?oiinoe 1 1,7% io na?aea/ii-ninoaeenouo
caaieaaaiee a eiio?ieueiie a?oiia e 9,3% n?aaee i?eieiaaoeo anie?ei: yoi
icia/aao 24 nianaiiuo aeecie ec eaaeaeie 1000 aieueiuo. A i?iea/aiiie
a?oiia ca?aaeno?e?iaaii oaeaea ianeieueei iaoaoaeueiuo ia?ooaiee
iicaiaiai e?iaiia?auaiey e iaoaoaeueiuo iiaoi?iuo eioa?eoia ieiea?aea.
Nouanoaoao anaai ianeieueei i?ioeaiiieacaiee e iacia/aieth anie?eia: ii
ia iiaeao i?eieiaoueny i?e auyaeaiiie aeia?/oanoaeoaeueiinoe,
e?iaioa/aiee iaioe/aneie ycau. iaoieiae/aneeo eciaiaieyo e?iae eee
oyaeaeie oi?ia aaiaoeoa. Anie?ei iiaeao eiiaaea aucaaoue a?iioiniaci o
anoiaoeeia. A ioee/ea io neooaoeee n o?iiaieeoe/aneeie n?aaenoaaie, iao
/aoeiai aeieacaoaeuenoaa acaeiinayce iaaeaeo yooaeoeaiinoueth eaea?noaa
e a?aiaiai, i?ioaaeoei n iiiaioa iiyaeaiey neiioiiia. Oai ia iaiaa,
anie?ei aeieaeai aeaaaoueny anai iaoeeaioai n ino?uie ei?iia?iuie
neiae?iiaie eae iiaeii ?aiueoa iinea oiai, eae aeeaaiic noaiiaeony
aa?iyoiui. Yoi ninoaaeyao 85-95% iaoeeaioia n iiaeoaa?aeaeaiiui
eioa?eoii ieiea?aea.
Aioea?eoie/aneea eaea?noaaiiua n?aaenoaa. Ianiio?y ia oi, /oi eeaeieaei
iiaeao nieaeaoue eiee/anoai neo/aaa aicieeiiaaiey aeaeoaei/eiaie
oea?eeeyoeee a ino?ie oaca eioa?eoa ieiea?aea, yoi eaea?noai
cia/eoaeueii oaaee/eaaao iianiinoue anenoieee. Iaoa-aiaeec 14
enneaaeiaaoaeueneeo ?aaio iieacae iacia/eoaeueiia iiauoaiea nia?oiinoe o
iaoeeaioia, iieo/aaoeo eeaeieaei ii n?aaiaieth n eiio?ieai.
Eniieueciaaiea yoiai eaea?noaa, eae i?ioeeaeoe/aneiai n?aaenoaa, ia
ii?aaaeaii.
Aaoa-aeieaoi?u. Auei i?iaaaeaii iiiai enneaaeiaaiee ii aioo?eaaiiiio
aaaaeaieth aaoa-aeieaoi?ia a ino?ie oaca eioa?eoa ieiea?aea, ec-ca eo
aiciiaeiinoe ia?aie/eaaoue ciio eioa?eoa, nieaeaoue /anoioo
aicieeiiaaiey oaoaeueiuo a?eoiee e nieaeaoue aieue. N?aaee 16000
aieueiuo, i?eiyaoeo o/anoea a enneaaeiaaieyo ISIS-2 ii eco/aieth
aioo?eaaiiiai aaaaeaiey aoaiieiea, auyaeee cia/eoaeueiia (? 85%, aaoa-aeieaoi?ia >35%,
eiaeaeoi?u AIO> 20%.
Anai iaoeeaioai iaiaoiaeeii ecia?eoue o?iaaiue eeieaeia,
i?aaeii/oeoaeueii a aeaiue iinooieaiey a aieueieoeo. Oa, o eiai o?iaaiue
eeieaeia iiauoai, aeieaeiu iieo/eoue ?aeiiaiaeaoeee ioiineoaeueii
aeeaou. Anee i?e yoii o?iaaiue eeieaeia ia nieceony, a cia/eoaeueiie
ia?a, i?aaeii/oaiea aeieaeii auoue ioaeaii eaea?noaaiiui n?aaenoaai aeey
nieaeaiey o?iaiy eeieaeia, a niioaaonoaee n e?eoa?eyie Scandinavian
Simvastatin Survival Study.
Iauai?aeoeeothuei a?a/ai. A oii neo/aa, anee iauai?aeoeeothuea a?a/e
ia?auie anooieee a eiioaeo n aieueiuie, o eioi?uo iiaeic?aaaaony eioa?eo
ieiea?aea, iie aeieaeiu eeai iaiaaeeaiii iiii/ue naie, eeai aucaaoue
a?eaaaeo nei?ie iiiiue eee (i?aaeii/oeoaeueiaa) naeaeaoue e oi, e
ae?oaia.
Anee iauai?aeoeeothuea a?a/e iiaoo i?eauoue e aieueiiio auno?i e iie
aeinoaoi/ii iao/aiu e eiatho iai?oaeiaaiea, iie iiaoo yooaeoeaii
i?iaanoe aeaoea?eeeyoeeth e o?iiaieecen.
Iie aeieaeiu auoue aiaea/aiu a eii?aeeie?oaioth ianoioth i?ia?aiio ii
ieacaieth ia?aie iiiiue ea?aeeieiae/aneei aieueiui.
Iie aeieaeiu oaeaeaoue aieueiiai, eae iiaeii ?aiueoa, iinea auienee ec
aieueieoeu, oaaaeeoueny, /oi eo ?aaaeeeoaoeey aeieaeiui ia?acii
i?aaieciaaia e i?aaeoniio?aoue iiaeoiaeyuea ia?u aeey aoi?e/iie
i?ioeeaeoeee.
I?aaiu cae?aaiio?aiaiey. I?aaiu cae?aaiio?aiaiey aeieaeiu
i?aaieciauaaoue iao/aiea ianaeaiey iniiaai oaoieee ?aaieiaoeee aieueiuo
n na?aea/iuie e eaai/iuie caaieaaaieyie, a a?eaaaeu nei?ie iiiiue
iniiaiui i?ia?anneaiui niiniaai iiaeaea?aeaiey aeecie.
Iie aeieaeiu oaaaeeoueny, /oi aeey aieueiuo n iiaeic?aieai ia inoaiiaeo
na?aeoea eee eioa?eo ieiea?aea, nicaeaia iioeiaeueiay nenoaia ooiaea,
iooai eii?aeeiaoeee aeayoaeueiinoe nei?ie iiiiue, iauai?aeoeeothueo
a?a/ae e ?aaioieeia aieueieoeu.
Iie aeieaeiu oaaaeeoueny, /oi ioaeaeaiea iaioeiaeiie iiiiue eiaao
iiaeoiaeyuee i?ioieie aeey ieacaiey auno?ie iiiiue aieueiui n eioa?eoii
ieiea?aea e, /oi niaoeeaeueii iao/aiiue ia?niiae aeaaeo?eo ana a?aiy.
Iie aeieaeiu iaania/eoue aeinoaoi/iui eiee/anoaii e?iaaoae aeey
eioaineaiiai ooiaea ca aieueiuie n eioa?eoii ieiea?aea. Aeieaeiu auoue
oa?aiaaou, i?ioaaeoea niaoeeaeecaoeeth ii ea?aeeieiaee.
Iie aeieaeiu iaania/eaaoue ?aaaeeeoaoeeth aieueiuo, auienaaoeony ec
aieueieoeu iinea eioa?eoa ieiea?aea.
Iie aeieaeiu oaaaeeoueny, /oi a eo nianoaaiiie aieueieoea eee ?aeiia
eiaaony aeinoaoi/ii aiia?aoo?u aeey i?ia?anneaiuo iaoiaeia ianeaaeiaaiey
e ea/aiey aieueiuo n ineiaeiaieyie iinea eioa?eoa ieiea?aea eee, anee
iao ia ianoa, naycaoueny n eaeeie-ieaoaeue o?aoe/iuie oeaio?aie.
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