Використання мембранного безперервного плазмаферезу в комплексному лікуванні пізніх гестозів: Автореф. дис… канд. мед. наук / Н.А. Резніченко, Ін-т

?INOEOOO IAAe?AO???, AEOOA?NOAA OA A?IAEIEIA??

Aeaaeai?? Iaaee/ieo Iaoe OE?A?IE

?aci?/aiei Iaoaey Aiaoie??aia

OAeE 618.3(008.6(085.382

Aeei?enoaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaeniiio
e?eoaaii?

i?ci?o aanoic?a

14.01.01 ( Aeooa?noai oa a?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a ( 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i. I.Ai?ueeiai IIC Oe?a?ie

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

*aeea Aieiaeeie? Ee?eeiae/,

caa?aeoth/ee eaoaae?ith aeooa?noaa, a?iaeieia?? oa ia?eiaoieia??
oaeoeueoaoo i?neyaeeieiiii? ina?oe Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?i. I.Ai?ueeiai IIC Oe?a?ie

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? AeAOEAAE* AAEAIOEIA
?AAeIEEI?AIA, caa?aeoth/a aeooa?nueeei a?aeae?eaiiyi aeno?aaai?oaeueieo
caoai?thaaiue aaa?oieo ?inoeoooo iaae?ao???, aeooa?noaa ? a?iaeieia??
AII Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani? Aaioeuee?anueeee Ai?en Ieoaeeiae/
caa?aeoth/ee eaoaae?ith aeooa?noaa ? a?iaeieia?? ? 1 Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey IIC Oe?a?ie

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe
?i.I.E.Ooieea IIC Oe?a?ie,
eaoaae?a aeooa?noaa, a?iaeieia?? oa ia?eiaoieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 11 ” n?/iy 2000 ?ieo i 13 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.553.01 ii caoenoo
aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaoe ca
niaoe?aeueiinoyie “Iaae?ao??y”, “Aeooa?noai ? a?iaeieia?y” i?e ?inoeooo?
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (04050, i. Ee?a, aoe.
Iaio?euenueeiai, 8).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?inoeoooo iaae?ao???,
aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (04050, i. Ee?a,
aoe. Iaio?euenueeiai, 8).

Aaoi?aoa?ao ?ic?neaiee “ 17 ” eenoiiaaea 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
Eaaoi?ia E.A.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. I?iaeaia i?ci?o aanoic?a — iaeia c iaeaeooaeuei?oeo
a no/ani?e iaaeeoeei?, ine?eueee ? iniiaiith i?e/eiith iaoa?einueei? oa
ia?eiaoaeueii? caoai?thaaiino? oa nia?oiino?. Iacaaaeath/e ia aaeeeo
e?euee?noue oai??e ?icaeoeo aanoico, aei oeueiai /ano ia ?nio? ?aeeiiai
iiaeyaeo ia iaoiaaiac oeueiai caoai?thaaiiy. A inoaii? ?iee c’yaeeeny
iia?aeiieaiiy i?i oa, ui a iniia? aeieeiaiiy ? ?icaeoeo aanoic?a
eaaeaoue ii?ooaiiy ?ioiieia?/ii? ?aaeoeaiino? iaoa??, a ie?ae c iiceoe??
?ioiieia?? ?icaeyaea?oueny ye aeeio?aiieaioao [Ianiai I.I. e niaao.,
1996].

?ioiia iaaeinoaoi?noue, ui aeieea? o iaoa??, i?eaiaeeoue aei
aaiiaeeiai?/ieo, aaiinoac?ieia?/ieo oa ?aieia?/ieo ii?ooaiue. Aiane?aeie
oeueiai aeieea? iie?i?aaiia ? iie?nenoaiia iaaeinoaoi?noue c ianooiiei
iaeiie/aiiyi a i?aai?ci? i?iaeoeo?a ii?ooaiiai iai?io — aiaeioienei?a,
oeeee?/ieo ?ioiieo eiiieaen?a, na?aaei?o iieaeoe, acioenoeo oeae?a.

O ca’yceo c oeei iiooe iaoiae?a aoaeoeaiiai e?eoaaiiy ae?iie c i?ci?i
aanoicii ? aeooaeueiith i?iaeaiith no/aniiai aeooa?noaa.

A inoaii? aeanyoe??//y ana a?eueoo oaaao ee?i?oeeno?a i?eaa?oathoue
iaiaaeeeaiaioici? aoaeoeai? iaoiaee e?eoaaiiy iie?aaeaioii? ae??, ye?
aeicaieythoue aeaanoe c i?aai?cio iaoieia?/i? aeaiaioe c iaoith
ei?aeoe?? noaio aaa?oii? [Aa?ai/aiei A.A. e niaao., 1990].

Iaeiei c iaea?eueo aoaeoeaieo iaoiae?a aoa?aioii? oa?ai?? ? iaia?aiiee
aacia?a?aiee ieaciaoa?ac (IA) [Aa?ai/aiei A.A. e niaao., 1990;
Aaoaaee?iaa A.I., Aa?aiia E.E., 1993; Aeeaiacyi Y.E., 1991].
E?eoaaeueiee aieea iaia?aiiiai aacia?a?aiiai IA, ii aeaiei aaoi??a,
?aae?co?oueny caaaeyee aeac?ioieneeaoe?eiiio, ?ioiiei?eaoth/iio,
?aiei?eaoth/iio oa aeeoociiio iaoai?ciai: aeaiaeyoueny aooiaioeo?ea,
?ioii? eiiieaene, i?iaeoeoe iaoaaie?cio, eiiiiiaioe ii?ooaieo oeaiei ?
ee?oei, iie?auo?oueny i?e?ioee?eoeyoe?y, ?aieia?/i? aeanoeaino? e?ia?,
o?ainii?o eenith.

A e?oa?aoo?? cono??/athoueny ?iaioe, i?enay/ai? canoinoaaiith IA o
aaa?oieo c i?aaeeaiin??th oyaeeiai nooiaiy [Aa?ai/aiei A.A. e niaao.,
1990; Aeeaiacyi Y.E., 1991; Aa?aiia E.E. e niaao., 1996], aea i?e
oeueiio a?aenooi? aeai? i?i aieea oeueiai iaoiaeo e?eoaaiiy ia ?ioiio
nenoaio oeeo ae?iie, iaia? oaeiae /?oei? noaie canoinoaaiiy oeueiai
aoa?aioiiai iaoiaeo oa?ai?? i?e aanoicao ??ciiai nooiaiy oyaeeino?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia ca?aeii c ieaiii IAe? IAe? iaaee/ieo i?iaeai n?i’? ? ?
o?aaiaioii eiiieaenii? oaie “Aacia/ia iaoa?einoai — a?ae ca/aooy aei
ia?iaeaeaiiy” IIC Oe?a?ie (? aea?ae. ?a?no?aoe?? 0197V002121, oeo? oaie
IE 97.06.17). Aaoi? ? aeeiiaaoeai oaie.

Iaoa aeine?aeaeaiiy. ?ic?iaeoe iaoeiai iaa?oioiaaio noaio e?eoaaiiy
i?ci?o aanoic?a oeyoii aeeoa?aioe?eiaaiiai canoinoaaiiy iaia?aiiiai
aacia?a?aiiai ieaciaoa?aco aeey cieaeaiiy ia?eiaoaeueii? caoai?thaaiino?
oa nia?oiino?.

Caaea/? aeine?aeaeaiiy.

Aea/eoe noai nenoaie aaiinoaco, ?ioiiee noaoon ? ??aaiue a?io?i?/ieo
ia?aiao??a ieacie e?ia? o ae?iie c o?c?ieia?/iei ia?aa?aii aaa?oiino?, c
aanoaoe?eiith a?ia?oaic??th oa c i?aaeeaiin??th na?aaeiueiai nooiaiy
oyaeeino?.

Ioe?ieoe noai ieiaea ? ooieoe?iiaeuei? iniaeeaino? oaoiieaoeaioa?iiai
eiiieaeno o aaa?oieo c i?ci?i aanoicii ??ciiai nooiaiy oyaeeino?.

Aea/eoe aieea iaia?aiiiai aacia?a?aiiai IA ia noai nenoaie aaiinoaco,
a?io?i?/i? oa ?ioiieia?/i? iieacieee e?ia? o ae?iie c aanoaoe?eiith
a?ia?oaic??th oa i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?.

Ioe?ieoe noai ieiaea ? ooieoe?th oaoiieaoeaioa?iiai eiiieaeno i?ney
canoinoaaiiy iaia?aiiiai aacia?a?aiiai IA a eiiieaeniiio e?eoaaii?
i?ciueiai aanoico.

Aeaoe ee?i?/io ioe?ieo aoaeoeaiino? oa iaa?oiooaaoe ia?aaaae aeeth/aiiy
iaia?aiiiai aacia?a?aiiai IA aei eiiieaeno e?eoaaiiy ae?iie c
aanoaoe?eiith a?ia?oaic??th oa i?aaeeaiin??th na?aaeiueiai nooiaiy
oyaeeino?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aea/aii aieea
iaia?aiiiai aacia?a?aiiai IA ia iieacieee ee?oeiiiai oa aoii?aeueiiai
?ioi?oaoo o ae?iie c aanoaoe?eiith a?ia?oaic??th oa i?aaeeaiin??th
na?aaeiueiai nooiaiy oyaeeino?.

Aia?oa aeaia ioe?iea noaio oaoiieaoeaioa?iiai eiiieaeno a ?acoeueoao?
canoinoaaiiy iaia?aiiiai aacia?a?aiiai IA a eiiieaeni?e oa?ai?? ae?iie c
aanoaoe?eiith a?ia?oaic??th oa i?aaeeaiin??th na?aaeiueiai nooiaiy
oyaeeino?.

Aia?oa aea/aii aieea iaia?aiiiai aacia?a?aiiai IA ia iieacieee nenoaie
aaiinoaco o ae?iie c i?ci?ie aanoicaie ??ciiai nooiaiy oyaeeino?.

Aeaia ee?i?/ia ioe?iea aoaeoeaiino? oa iaoeiaa iaa?oiooaaiiy aeeth/aiiy
iaia?aiiiai aacia?a?aiiai IA aei eiiieaeniiai e?eoaaiiy ae?iie c
aanoaoe?eiith a?ia?oaic??th oa i?aaeeaiin??th na?aaeiueiai nooiaiy
oyaeeino? ? ?ic?iaeai? noaie eiai aeai?/iai aeei?enoaiiy.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeaia aeey i?aeoe/ii?
ioi?iie caei?ia’y noaia aeeoa?aioe?eiaaiiai aeeth/aiiy iaia?aiiiai
aacia?a?aiiai IA aei eiiieaenii? oa?ai?? i?ci?o aanoic?a a?aeiia?aeii
aei nooiaiy oyaeeino? inoaii?o, aeicaiey? aeinyaoe a?eueo ae?aaeaiiai
ee?i?/iiai aoaeoo — cieaeaiiy aeiaaee?a aeeaiin?? ia 28%, ia?aaaae
a?eueo eaaeeo oi?i oeueiai oneeaaeiaiiy aaa?oiino?, ciaioaiiy a 2 ?ace
/anoioe ia?eiaoaeueii? iaoieia??.

Cai?iiiiiaaia noaia eiiieaeniiai e?eoaaiiy i?ciueiai aanoico c
aeeth/aiiyi iaia?aiiiai aacia?a?aiiai IA aeei?enoiao?oueny a iieiaiaeo
a?aeae?eaiiyo Aeiiaoeueeiai aea?aeaaiiai ?aa?iiaeueiiai oeaio?o ioi?iie
iaoa?einoaa oa aeeoeinoaa, Aei?i?iiao?ianueei? iaeanii? ee?i?/ii?
e?ea?i?, i?nueei? e?ea?i? ? 2 i?noa Ia??oiiey, oeaio?aeuei?e i?nuee?e
e?ea?i? i?noa ?iae??ai, i?nueei? e?ea?iy ? 1 i?noa Iae??aee oa
oeaio?aeueii? i?nueei? e?ea?i? i?noa Aieiaea?nueea.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii i?iaaaeaii ianoaaeaiiy 150
aaa?oieo ae?iie o oa?i?i? 25(36 oeaei?a c aanoaoe?eiith a?ia?oaic??th oa
i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?, a oaeiae 26 ae?iie c
o?c?ieia?/iei ia?aa?aii aaa?oiino?.

Aaoi? naiino?eii e?eoaaea ae?iie c aanoaoe?eiith a?ia?oaic??th oa c
i?aaeeaiin??th na?aaeiueiai nooiaiy. Iaa?oiooaaea noaio aeei?enoaiiy
iaia?aiiiai aacia?a?aiiai IA, yeee ia? ?ioii?aiei?eaoth/o ae?th oa
aeac?ioieneeaoe?eiee aoaeo. I?iaiaeeea naiino?eii i?ioeaaeo?o IA.

Naiino?eii i?iaiaeeea e?oa?aoo?iee iiooe, aiae?c oa iai??eiaoaaiiy c
i?eaa?oaiiyi no/anii? e?oa?aoo?e, iienoaaea ?acoeueoaoe aeine?aeaeaiue,
aeaaaea ?o ?ioa?i?aoaoe?th. I?iaaaeaii aiae?c io?eiaieo ?acoeueoao?a oa
?o iaoaiaoe/ia ia?iaea.

Ai?iaaoe?y ?acoeueoao?a aeine?aeaeaiiy. Iniiai? iieiaeaiiy aeena?oaoe??
oa ?acoeueoaoe iaoeiaeo aeine?aeaeaiue aeieeaaeaii e iaaiai?aii ia
can?aeaii? eaoaae?e aeooa?noaa, a?iaeieia?? oa ia?eiaoieia?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo (1998), can?aeaii? A/aii? ?aaee IAe? iaaee/ieo i?iaeai
n?i’? (1999), iaeaniiio oiaa?enoa? aeooa??a-a?iaeieia?a Aeiiaoeueei?
iaeano? (1998), X-io c’?cae? aeooa??a-a?iaeieia?a Oe?a?ie (1996).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 8 iaoeiaeo i?aoeue, c
ieo 3 noaoo? a oeaio?aeueieo iaaee/ieo aeo?iaeao, 2 a ca??ieeao iaoeiaeo
i?aoeue, 3 – o oacao aeiiia?aeae ia c’?cae? ? eiioa?aioe??.

Ianya ? no?oeoo?a aeena?oaoe??. ?iaioa aeeeaaeaia ia 146 noi??ieao
iaoeiiieniiai oaenoo ? neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e,
/ioe?ueio ?icae?e?a aeanieo aeine?aeaeaiue, aiae?co ? ocaaaeueiaiiy
?acoeueoao?a aeine?aeaeaiue, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e,
nieneo aeei?enoaieo aeaea?ae. Nienie aeei?enoaieo aeaea?ae i?noeoue 162
?iaioe ? caeia? 20 noi??iie. Aeena?oaoe?y ?ethno?iaaia 27 oaaeeoeyie ? 7
?enoieaie, ye? caeiathoue 24 noi??iee.

Iniiaiee ci?no ?iAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy.

Iaie i?iaaaeaii ianoaaeaiiy 150 aaa?oieo a oa?i?iao 25(36 oeaei?a, eio??
iaee ??ci? neiioiie i?ciueiai aanoico.

Ia?oo a?oio neeaee 76 ae?iie, ye? io?eioaaee a eiiieaeniiio e?eoaaii?
i?ciueiai aanoico aacia?a?aiee iaia?aiiee ieaciaoa?ac. C ieo Ia a?oia —
55 ae?iie — iaoe??ioee c aanoaoe?eiith a?ia?oaic??th, Ia a?oia — 21
ae?iea — iaoe??ioee c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?.

Aei ae?oai? a?oie oa?eoee 74 aaa?oi?, eio?? io?eioaaee caaaeueiii?eeiyoo
noaio oa?ai??, ca?aeii c iaoiaee/ieie ?aeiiaiaeaoe?yie IIC Oe?a?ie
(1997), c ieo IIa a?oia — 52 ae?iee — iaoe??ioee c aanoaoe?eiith
a?ia?oaic??th, IIa a?oia — 22 aaa?oi? — c i?aaeeaiin??th na?aaeiueiai
nooiaiy oyaeeino?. Eiio?ieueio a?oio neeaee 26 ae?iie c o?c?ieia?/iei
ia?aa?aii aaa?oiino?.

Aeey ioe?iee nooiaiy oyaeeino? aanoico ie ei?enooaaeeny “I?aeia?iaeiith
eeaneo?eaoe??th caoai?thaaiue, o?aai ? i?e/ei nia?o? X ia?aaeyaeo”. —
AEaiaaa: AIC, 1995. — O. 1 (/anoeia 2). — N. 54(56.

A?io?i?/i? ianoaaeaiiy i?iaiaeeee oeyoii aecia/aiiy ??ai?a i?yiiai e
iai?yiiai a?e??oa?io, caaaeueiiai a?eea, e?aaoeieio, aetheice, o?aeoe?e
a?eea, oa?iaio?a: ania?oaoai?iio?ainoa?ace (AnAO),
aeai?iai?iio?ainoa?ace (AeAO), eoaeii? oinoaoace (EO), a oaeiae
aeaeo?ie?o?a: Ca2+, Na+, K+, aeey /iai aeei?enoiaoaaee noaiaea?oi?
?aaeoeae o??i “Medix” (O?ieyiae?y), “Merck” (I?ia//eia), “BMGmbh”
(Aano??y) oa a?io?i?/i? aiae?caoi?e OI(9, OI(901 (O?ieyiae?y) c
i?e?ii?ioeani?ii ? iaai?ii a?aeiia?aeieo eaai?aoi?ieo i?ia?ai.

Aeine?aeaeoaaee ?ia?a?oi?e cai?oaiiy ? ia?ea?e aioo??oiueinoaeeiiiai
o?iiaiooai?aiiy: aeoeai?noue AO III — ca aeiiiiiaith o?iiiaaiieo iaai??a
noano?ao?a c iaai?o Berichrom — AO III Behringwerke (I?ia//eia);
eiioeaio?aoe?th AO III — iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ia
ieanoeieao Nor-Partigen; eiioeaio?aoe?th eiiieaeno o?iia?i-aioeo?iia?i
III (OAO) — ca aeiiiiiaith ?ioiioa?iaioii? nenoaie Ensynost-OAO ia
i?eeaae? Vitatron (Aieaiae?y); eiioeaio?aoe?th o?a?iiaeoeio — iaoiaeii
?aae?aeueii? ?ioiiaeeooc?? ia ieanoeieao LC-Partigen; aeoeai?noue
i?ioa?io C — a?oai?i K caeaaeiiai ?ia?a?oi?o aeoeaiaaieo aenaea?ao?a
cai?oaiiy Va ? VIIIa — ca aeiiiiiaith o?iiiaaiieo noano?ao?a ?c
noaiaea?oieo iaai??a Behringwerke; eiioeaio?aoe?th
Acid-(-Glycoprotein-a?eea “aeoeaii? oace” oa ?ia?a?oi?o aa?aaaoe??
o?iiaioeeo?a — iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ia ieanoeieao
Nor-Partigen; eiioeaio?aoe?th ieaci?iiaaio (PL) — iniiaiiai noano?aoo
o?a?eiie?oe/ii? nenoaie — ca aeiiiiiaith ?aae?aeueii? ?ioiiaeeooc?? ia
ieanoeieao M-Partigen; ai?no ?ia?a?oi?o aeoeaaoi?a ieaci?iiaaio (PAY) —
ca aeiiiiiaith oano-iaai?o PAY-Oano Behringwerke.

E?euee?noue O-, A-e?ioioeeo?a, ?o noaiiioeyoe?e oa NK-ee?oei aecia/aee a
ia?eoa?e/i?e e?ia? ianoaaeaieo a?oi ae?iie iaoiaeii iai?yii? ?ioii
oeoi?anoeaioe?? c aioiaeie ei?aeyoe?eieie iaai?aie a?aeiia?aeieo
iiiieeiiaeueieo aioeo?e, i?/aieo O?OOe o??ie Ortho Diagnostics (NOA).
I?e oeueiio ee?oeie, aeyaeai? CD3 iiiieeiiaeueieie aioeo?eaie,
?aeaioeo?eoaaee ye caaaeuei? O-e?ioioeeoe, CD4 — ye
O-oaeia?e/?iaeoeoi?e, CD8 — ye O-noi?ani?e/oeeoioiene/i? ee?oeie, CD22 —
ye A-e?ioioeeoe ? CD16 — ye “ioeueia?” ee?oeie aai iaoo?aeuei? e?ea?e
(NK-ee?oeie).

Aeey ioe?iee ?ioii?aaoeyoe?? iaie aoei ?ic?aoiaaii ?ioii?aaoeyoi?ia
ni?aa?aeiioaiiy O-oaeia??a aei O-noi?ani??a, ye CD4 aei CD8 (CD4/CD8).

Ai?no Ig G, A, M a ne?iaaooe? e?ia? aecia/aee iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? a aae? ca Mancini (1965).

Eiioeaio?aoe?th ano??ieo (A3), i?iaanoa?iio (Ia), ieaoeaioa?iiai
eaeoiaaio (IE) aecia/aee ?aae?i?ioiieia?/iei iaoiaeii c aeei?enoaiiyi
eiia?oe?eieo noaiaea?oieo iaai??a ?aaeoea?a o??ie “Immunotech” (*ao?y) ?
OII “EAIO” (Aaea?onue). Aiae?c aeeiioaaee a oi/i?e a?aeiia?aeiino? aei
aeac?aie ?ino?oeoe?? c aeei?enoaiiy iaai??a.

I?iae ?aae?iiao?oaaee ia i?ioyc? 1 oaeeeie ia e?/eeueieeo (-?iioeuen?a
“AAIIA” (Oai?ueia). ?acoeueoaoe aiae?co ai?iii?a ae?aaeaee a iiieue/e.

E?ia aeey eaai?aoi?ieo aeine?aeaeaiue caae?aee a oiiaao iai?ioeyoe?eiiai
eaa?iaoo c aeei?enoaiiyi iaiao?aeieo i?aaee anaioeee e aioenaioeee i?e
iino?ei?e aieiaino? 70(80 % oa ina?oeaiino? 250 ethen/i2 a?aioe? c 800
aei 900 iaoua c eoa?oaeueii? aaie a ia’?i? 10 ie. sse eiina?aaio
aeei?enoiaoaaee AAeOA a aeic? 1 ia/ie e?ia?. Iaaaeii i?ney caai?o e?ia
oeaio?eooaoaaee ia i?ioyc? 30 oaeeei i?e 3000 g ia oeaio?eooc? E-23
(I?ia//eia). Io?eiaio ieacio e?ia? cae?aee a iie?i?ii?eaiia? o?oae
ia’?iii 1,5 ie oeio “Yiiaiaei?o” ? aei i?iaaaeaiiy aiae?co caa??aaee i?e
oaiia?aoo?? +4(C; aeey a?eueo o?eaaeiai caa??aaiiy (aea ia a?eueo aeaio
oeaei?a) e?ia caii?iaeoaaee ? caa??aaee i?e oaiia?aoo?? (20( C a
ii?iceeuei?e eaia??.

Noaoenoe/io ia?iaeo io?eiaieo aeaieo i?iaiaeeee iaoiaeaie aa??aoe?eii?
noaoenoeee ? ei?aeyoe?eiiai aiae?co ca aeiiiiiaith iaeaoo i?eeeaaeieo
i?ia?ai “Microsoft Exel for Windows 97” ia AII IBM “Pentium-166”.
A??ia?aei?noue ??cieoeue i?ae a?oiaie, eio?? ii??aithaaee aecia/aee ca
iaoiaeii No’thaeaioa, a oaeiae eooiaiai ia?aoai?aiiy ca O?oa?ii. A
?iaio? a?aoiaoaaeeny o?eueee a??ia?aei? (P<0,05) ei?aeyoe?ei? ca'ycee. ?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Aeai? aiaiiaco, ia?aa?ao aaa?oiino?, iieia?a ? noai iiaiia?iaeaeaieo aea/aee ii ?iaeea?aeoaeueieo ea?oeao, ?noi??yi iieia?a oa ea?oeao ?icaeoeo iiaiia?iaeaeaieo. A?eiaee ? nioe?aeueiee neeaae ae?iie ianoaaeaieo a?oi ?iciiae?eeeeny ianooiiei /eiii. sseui a eiio?ieuei?e a?oi? iaea?eueoa e?euee?noue aaa?oieo aoea o a?oe? a?ae 20 aei 25 ?ie?a (41,5 %), oi a iniiai?e a?oi? oa a?oi? ii??aiyiiy — a?ae 26 aei 35 ?ie?a (28,9 % ? 32,3 % a?aeiia?aeii), ui na?ae/eoue i?i na?eicio ?ieue a?eo ye oaeoi?a ?eceeo iaoieia??, yea aea/aeany. Iaiao?aeii oaeiae a?aecia/eoe aeinoia??ii aenieo /anoioo o/i?a (nooaeaio?a) a iniiai?e a?oi? (21,0 %) ? a?oi? ii??aiyiiy (17,5 %). A?aeiinia e?euee?noue ia?oi- ? iiaoi?iiaaa?oieo ia?oi?iaey/eo (30,2 % ? 36,8 % a iniiai?e; 34,3 % ? 32,3 % a a?oi? ii??aiyiiy; 41,5 % ? 26,9 % a eiio?ieuei?e), a oaeiae iiaoi?iiaaa?oieo iiaoi?ii?iaey/eo (33,0 %, 33,4 %, 33,3 % a?aeiia?aeii) i?eaeecii iaeiaeiaa a ianoaaeaieo a?oiao. Iaea?eueo /anoei ? ?aii?i neiioiiii i?ciueiai aanoico aoei iii??ia ca?eueoaiiy iane o?ea, eio?a a 17,1 % ? a 16,2 % aeiaaee?a niinoa??aaeiny o ae?iie iniiaii? a?oie ? a?oie ii??aiyiiy a I o?eiano?? aaa?oiino? oa a 63,2 % ? a 58,1 % aeiaaee?a a?aeiia?aeii aei 25 oeaei?a. Iaea?eueo i?ci?i neiioiiii niinoa??aaany na/iaee neiae?ii. Oaeoi?aie ?eceeo ?icaeoeo i?ciueiai aanoico aoee: ?aii?e ii/aoie ia?oi? iaino?oaoe?? (11,76 % aeiaaee?a), o?ii?/i? caiaeuei? caoai?thaaiiy aai?oae?e (15,0 %); iaaee/i? e naiia?euei? aai?oe (10,29 % ? 13,2 % a?aeiia?aeii), ia?aianaiee i?ci?e aanoic i?ae /an iiia?aaei?o aaa?oiinoae (19,23 %). Iaea?eueo /anoeie oneeaaeiaiiyie oe??? aaa?oiino? (67,1 % ae?iie iniiaii? a?oie ? 77,9 % a?oie ii??aiyiiy) aoee aiai?y (a oa?i?iao 15(40 oeaei?a o 67,5 % ? o 77,9 % a?aeiia?aeii) oa caa?ica ia?a?eaaiiy aaa?oiino? c 15 ii 28 oeaei?. Aeey eaaeiai ia?aa?ao i?ciueiai aanoico oa?aeoa?iee a?eueo iecueeee ai?no caaaeueiiai a?eea e aeueaoi?i?a a ne?iaaooe? e?ia? o 28,6 % aaa?oieo oa a?aenooi?noue aoaeue-yeeo aeinoia??ii cia/oueo ci?i a eiioeaio?aoe?? caaaeueiiai a?e??oa?io, e?aaoeieio ? aetheice, a oaeiae aeaeo?ie?o?a Na+, K+, Ca2+ ? oa?iaio?a AeAO, AnAO, EO a ne?iaaooe? e?ia?. Ia?aa?a i?aaeeaiin?? na?aaeiueiai nooiaiy oyaeeino? noi?iaiaeaeo?oueny aeinoia??ii a?eueo iecueeei ai?noii caaaeueiiai a?eea oa eiai aeueaoi?iiai? o?aeoe??, cieaeaiith eiioeaio?aoe??th K+ ? Ca2+ a ieaci? e?ia? ia oii? i?aeaeuaiiai ai?noo Na+ ? EO o an?o ae?iie oe??? a?oie. O 32,8 % aaa?oieo niinoa??aaeany i?aeaeuaia eiioeaio?aoe?y e?aaoeieio, o 34,6 % iaoe??ioie — a?eueo aenieee ??aaiue oieanoa?eio a ieaci? e?ia? oa o 56,8 % oe??? a?oie — i?aeaeuaia eiioeaio?aoe?y AeAO e AnAO a ieaci? e?ia?. ?c c?inoaiiyi oyaeeino? i?ciueiai aanoico c?inoaee i?iyae a?ia?eiaaoeyoe?? a nenoai? aaiinoaco (oaae.). Iaie anoaiiaeaii, ui o ae?iie ?c na?aaei?i nooiaiai oyaeeino? i?aaeeaiin?? niinoa??aa?oueny i?aeaeuaiee ai?no (0,22(0,02 a/e, P<0,05) ? aeniea aeoeai?noue ieaci?iiaaio (126,8(7,7 %, P<0,05) a ii?aeiaii? c aeayeei i?aeaeuaiiyi eiioeaio?aoe?? o?a?iiaeoeio (0,39(0,03 a/e). Ioaea, o?a?eiie?oe/iee iioaioe?ae e?ia? i?aeaeuaiee, aea i?e oeueiio, ye aeacaii aeua, ?ia?a??oaaiiy o?a?eiie?co cieaeaii. O?iia?i-aioeo?iia?i ???, eeneee (1-ae?eii?ioa?i ? o?a?eiiaai iiaeia ?icaeyaeaoe ye ia?ea?e aioo??oiueinoaeeiii? aeoeaaoe?? cai?oaiiy e?ia?. O aaa?oieo c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino? i?aeaeuaia eiioeaio?aoe?y OAO (0,37(0,01 a/e, P<0,05), eeneiai (1-ae?eii?ioa?io (0,89(0,02 a/e, P<0,05) ? o?a?eiiaaio (6,3(0,6 a/e, P<0,05). O?a?eiiooai?aiiy oa o?iiaoaaiiy i?e?inoaeei, a oiio /ene? ? a ieaoeaio?, a?ae?a?athoue aaeeeo ?ieue o ?icaeoeo aeooa?nueeeo ? ia?eiaoaeueieo oneeaaeiaiue. I?e ?icaeoeo i?ciueiai aanoico iaie aeyaeai? cia/i? ci?ie O-nenoaie ?ioi?oaoo o ii??aiyii? c o?c?ieia?/iith aaa?oi?noth (?en.). C ia?inoaiiyi nooiaiy oyaeeino? caoai?thaaiiy aeinoia??ii cieaeo?oueny caaaeueia e?euee?noue e?ioioeeo?a e?ia? oa a?aeiiniee ??aaiue O-e?ioioeeo?a (CD3-ee?oei) ? O-noi?ani??a/oeeoioiene/ieo ee?oei (CD8-e?ioioeeo?a) ia oii? a?aeiiniiai ca?eueoaiiy CD4-e?ioioeeo?a (O-oaeia??a/?iaeoeoi??a) i?e eaaeiio ia?aa?ao i?ciueiai aanoico ? cieaeaiiy ??aiy inoaii?o i?e i?aaeeaiin?? na?aaeiueiai nooiaiy oyaeeino?. Ni?aa?aeiioaiiy CD4/CD8 i?aeaeuo?oueny aei 1,93 i?e aanoaoe?ei?e a?ia?oaic?? oa cieaeo?oueny aei 1,32 i?e na?aaeiueiio ia?aa?ao caoai?thaaiiy. Ci?ie a ?ioii?e nenoai? ia oii? ?icaeoeo ee?i?/ii? ea?oeie i?ciueiai aanoico a caeaaeiino? a?ae nooiaiy oyaeeino? caoai?thaaiiy aoee ianooiieie. Aanoaoe?eia a?ia?oaic?y noi?iaiaeaeo?oueny aeinoia??iei cieaeaiiyi an?o eean?a ?ioiiaeiaoe?i?a, caaaeueii? e?eueeino? e?ioioeeo?a, a?aeiiniiai ??aiy O-ee?oei ? O-noi?ani??a (CD8-e?ioioeeo?a/oeeoioiene/ieo ee?oei) ia oii? a?aeiiniiai ca?eueoaiiy CD4-e?ioioeeo?a (O-oaeia??a/?iaeoeoi??a), a oaeiae i?aeaeuaiiyi ni?aa?aeiioaiiy CD4/CD8. ?icaeoie i?aaeeaiin?? na?aaeiueiai nooiaiy oyaeeino? oa?aeoa?eco?oueny ae?aaeaiei i?eai?/aiiyi aioeo?eiaaiaco, iaae?iiyi ??aiy O-e?ioioeeo?a (CD3) oa ??ceei cieaeaiiyi e?eueeino? CD4-ee?oei (O-oaeia??a/?iaeoeoi??a) ? CD8-e?ioioeeo?a (O-noi?ani??a/oeeoioiene/ieo ee?oei), a oaeiae cieaeaiiyi ni?aa?aeiioaiiy i?ae ieie aei 1,32. Io?eiai? ?acoeueoaoe ni?aiaaeathoue c aeaieie A.I.Naaaeueaaie (1998); A.E.eoeaeiaa (1998). ?acoeueoaoe i?iaaaeaieo iaie aeine?aeaeaiue oo?iaiiai ieiaea o aaa?oieo c i?ci?i aanoicii na?ae/aoue i?i iani?eyoeeaee aieea oeueiai oneeaaeiaiiy aaa?oiino? ia na?oeaao ae?yeuei?noue ? aaeaioaoe?eii-eiiiainaoi?i? iiaeeeaino? ieiaea oei a?eueoa, /ei oyae/a ia?aa?a i?ciueiai aanoico. Ia iniia? io?eiaieo aeaieo iaoiaaiaoe/ii iaa?oioiaaiei aoei aeeth/aiiy a eiiieaenio oa?ai?th i?ciueiai aanoico aacia?a?aiiai iaia?aiiiai ieaciaoa?aco, e?eoaaeueia ae?y yeiai ?aae?co?oueny caaaeyee aeac?ioieneeaoe?eiiio, ?ioiiei?eaoth/iio oa aeeoociiio iaoai?ciai. An? aaa?oi? iniiaii? a?oie ? a?oie ii??aiyiiy io?eioaaee eiiieaenio oa?ai?th i?ciueiai aanoico ??ciiai nooiaiy oyaeeino? ca?aeii c iaoiaee/ieie ?aeiiaiaeaoe?yie IIC Oe?a?ie (1997). AE?ieai iniiaii? a?oie aei eiiieaeno e?eoaaeueieo caoiae?a aoei aeeth/aii iaia?aiiee aacia?a?aiee IA. I?ae /an i?ioeaaeo?e a?aeaoaa?oueny iaaaeeeee caa?? e?ia? (aei 15 ie) ? aiaeii/an — iiaa?oaiiy a?eo?ioeeoa?ii? iane a e?ia’yia ?onei. I?e aaa?oiino?, yea oneeaaeith?oueny i?aaeeaiin??th, aeieea? aeao?oeeo IOeE, ? a?aa?oaoe?eiee IA noa? aa?aneaiei. Naaine iaia?aiiiai aacia?a?aiiai IA i?iaiaeeee ca aeiiiiiaith aia?aoa “Aaiin(IA” (?in?y), /a?ac iaia?aiiee ieaciio?eueo? IIA(800 (o?eueo?aoe?eia ieiua — 800 ni2). Ca naain aeaiaeeee 800,0(50,0 ie aenoocaoo, oiaoi 600,0(50,0 ie ieacie. Eo?n neeaaeaany c aeaio naain?a c ?ioa?aaeii 7 aei?a. Noaiaea?oia ieaciia?aeiiaeaiiy i?e aoa?ac? neeaaeaeiny c 100(200 ie 10(15 % ?ic/eio aeueaoi?io, 200 ie ?aiiie?aethe?io, 400(500 ie o?c?ieia?/iiai ?ic/eio (ni?aa?aeiioaiiy aeaaaeaii? ieacie ? ieaciicai?uoaa/?a neeaei 1 : 1,4). Aeuacacia/ai? ?ic/eie oa ?o ni?aa?aeiioaiiy, ia iaoo aeoieo, ? iioeiaeueieie i?e i?iaaaeaii? iaia?aiiiai aacia?a?aiiai IA o aaa?oieo c i?ci?i aanoicii. O?eaae?noue iaia?aiiiai aacia?a?aiiai IA a na?aaeiueiio neeaaea? 1,3(0,15 aiaeeie. Aei ? i?ney eiaeii? i?ioeaaeo?e ioe?ithaaee noai aaa?oii?, aecia/aee /anoioo na?oeaaeo nei?i/aiue, a?oa??aeueiee oene nenoie?/iee oa ae?anoie?/iee ia iaio ?oeao. Oneeaaeiaiue i?e i?iaaaeaii? iaia?aiiiai aacia?a?aiiai IA ia niinoa??aaeiny. Aeyaeaii a?eueo ni?eyoeeaee ia?aa?a aaa?oiino?, ?iaeiaiai aeoo ? i?neyiieiaiaiai ia??iaeo o ae?iie iniiaii? a?oie ia a?aei?io a?ae a?oie ii??aiyiiy. *anoioa oneeaaeiaiue cia/ii ieae/a, i?ae o ae?iie, ye? io?eioaaee o?eueee e?eoaaiiy ca?aeii iaoiaee/ieo ?aeiiaiaeaoe?e (p < 0,05). Cieaeo?oueny /anoioa a?iien?? ieiaea a?eueo i?ae o 2 ?ace oa ano?en?? iiaiia?iaeaeaiiai. E??i oiai, a a?oi? ii??aiyiiy aeoaea aenieee a?aenioie aaaeii?iaeueiiai ?ic?iaeaeaiiy (66,7 % ? 45,0 % a?aeiia?aeii), aea iaeiei c iieacaiue aoea iaaoaeoeai?noue oa?ai??. Iieacieee o?ce/iiai ?icaeoeo ae?oae o ae?iie, eio?ei aoei i?iaaaeaii iaia?aiiee aacia?a?aiee IA aoee aeueie, i?ae o ae?iie, ye? aeio?eioaaeenue cae/aeii? oa?ai??. I?iaaaeai? iaie aeine?aeaeaiiy ii??aiyeueii? ioe?iee aieeao caaaeueiii?eeiyoi? oa?ai?? o ae?iie c aanoaoe?eiith a?ia?oaic??th oa c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino? c aeeth/aiiyi iaia?aiiiai aacia?a?aiiai IA ia a?io?i?/i? iieacieee, ye? aea/aeeny, aeicaieeee c?iaeoe ianooii? aeniiaee. Aeei?enoaiiy iaia?aiiiai aacia?a?aiiai IA a eiiieaeniiio e?eoaaii? aaa?oieo c i?ci?i aanoicii Ia ? Ia a?oi ia? ae?aaeaiee iiceoeaiee aieea ia aeeiai?eo caaaeueiiai a?eea, eiioeaio?aoe?th aeueaoi?i?a, ((aeiaoe?i?a, e?aaoeieio, oieanoa?eio ? oa?iaio?a AnAO ? EO i?ney e?eoaaiiy, ii?iae?coth/e ?o ai?no a ne?iaaooe? e?ia? o aeinoia??ii a?eueoi? e?eueeino? aaa?oieo, i?ae o?aaeeoe?eia oa?ai?y (p < 0,05). Aeeth/aiiy iaia?aiiiai aacia?a?aiiai IA ia iaei aeinoia??iiai aieeao ia /anoioo aeiaaee?a o?c?ieia?/ii? eiioeaio?aoe?? aeaeo?ie?o?a K+, Na+ ? Ca2+ a ieaci? e?ia? aaa?oieo Ia ? Ia a?oi. Aiai?y/e i?i ci?ie a nenoai? aaiinoaco o aaa?oieo c i?ci?i aanoicii, iiaeia c?iaeoe aeniiaie, ui i?ney i?iaaaeaiiy iaia?aiiiai aacia?a?aiiai IA cia/ii /ano?oa cieaeo?oueny ? i?eoiaeeoue aei ii?ie eiaaoeyoe?eiee iioaioe?ae e?ia? ca ?aooiie ieaciaii? oa o?iiaioeeoa?ii? eaiie. Ca?eueoeeanue e?euee?noue o?iiaioeeo?a o 97,7 % ae?iie c a?oa??aeueiith a?ia?oaic??th ? o 89,3 % - c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?, a ?o aa?aaaoe?eia aeoeai?noue ciaioeeanue ia 9,9 %. I?e oeueiio aeoeai?noue ?ia?a?oi??a cai?oaiiy ? o?a?eiie?co oa o?a?eiie?oe/iee iioaioe?ae caeeoathoueny ia iiia?aaeiueiio ??ai?. A oie aea /an ia?ea?e (o?iia?i-aioeo?iia?i ???, (1-ae?eii?ioa?i, o?a?eiiaai) na?ae/aoue i?i cieaeaiiy i?ioean?a aioo??oiueinoaeeiiiai cai?oaiiy e?ia?. Oaeei /eiii, aeeth/aiiy iaia?aiiiai aacia?a?aiiai IA a eiiieaenio oa?ai?th aaa?oieo c i?ci?i aanoicii aaeueio? ia?aa?a o?ii?/iiai AeAC-neiae?iio. O aaa?oieo iniiaii? a?oie cia/ii iie?aueeeny iieacieee ?ioiia?aie. Ii?iae?coaaany ai?no O-ee?oei (ND3) o 95,3 % c eaaeei ia?aa?aii aanoico oa o 88,5 % c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?. Ni?aa?aeiioaiiy O-oaeia??a aei O-noi?ani??a o 86,4 % iaaeeaeaeinue aei iieaciee?a i?e o?c?ieia?/i?e aaa?oiino?. Oea ia? aaeeea cia/aiiy, ine?eueee a iao /an aaaaea?oueny, ui ci?ie aaeaino O-oaeia??a ? O-noi?ani??a a a?e noi?an?? ? aaaeeeaei iaoai?ciii ?ioiieia?/iiai caaacia/aiiy aaa?oiino?. ?acoeueoaoe i?iaaaeaieo iaie aeine?aeaeaiue aia?oa aeiaaee aenieiaoaeoeaiee ?ioiiiiaeoethth/ee aieea iaia?aiiiai aacia?a?aiiai IA ia i?aai?ci aaa?oieo ae?iie c aanoaoe?eiith a?ia?oaic??th oa c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino? ? ? na?eiciith i?aenoaaith aeey aeeth/aiiy oeueiai iaoiaeo e?eoaaiiy aei noaie oa?ai?? aeaiiai oneeaaeiaiiy aaa?oiino?. Ooieoe?iiaeueia aeoeai?noue oaoiieaoeaioa?ii? nenoaie o aaa?oieo c i?ci?i aanoicii i?ney i?iaaaeaiiy iaia?aiiiai aacia?a?aiiai IA i?aeaeueeany (p < 0,05). O ae?iie c i?ci?i aanoicii Ia a?oie aeei?enoaiiy iaia?aiiiai aacia?a?aiiai IA iaei i?yiee iiceoeaiee aieea ia na?oeaao ae?yeuei?noue ieiaea, i?eaaei aei ii?iae?caoe?? iieaciee?a ea?ae?ioieia?ao?? a na?aaeiueiio o 90,8 % ae?iie ? o 80,4 % aeiaaee?a iie?aueeeny aaeaioaoe?eii-eiiiainaoi?i? iiaeeeaino? ieiaea, ui ia 21,9 % a?eueoa, i?ae a ?acoeueoao? caaaeueiii?eeiyoi? oa?ai??. Oaeei /eiii, ?acoeueoaoe aeine?aeaeaiue i?aeoaa?aeeee aenieo aoaeoeai?noue ?ic?iaeaii? iaie oa?ai?? i?ciueiai aanoico, ui aeicaiey? ?aeiiaiaeoaaoe ?? aeey ai?iaaaeaeaiiy a i?aeoeeo ?iaioe ?iaeiiii?aeieo caeeaae?a Oe?a?ie. Aeniiaee ?icaeoie i?ciueiai aanoico aaa?oieo noi?iaiaeaeo?oueny cieaeaiiyi caaaeueiiai a?eea, aeueaoi?iiai? o?aeoe??, a oaeiae aeinoia??iei c?inoaiiyi (-aeiaoe?i?a, AaAO, AnAO ? eoaeii? oinoaoace. C?inoaiiy nooiaiy oyaeeino? i?ciueiai aanoico noi?iaiaeaeo?oueny ci?iith eiaaoeio?a?eiie?oe/ieo aeanoeainoae e?ia? o iai?yieo a?ia?eiaaoeyoe??. Ca?eueoo?oueny eiioeaio?aoe?y o?a?eiiaaio, na?aaei? cia/aiiy ?iaeaeno o?iiaiieanoe/iiai iioaioe?aeo ia oii? cieaeaiiy iieacieea o?iiaiaeanoia?aie ? i?aeaeuaiiy aa?aaaoe?eieo aeanoeainoae o?iiaioeeo?a ye i?e noeioeyoe?? AAeO, oae ? i?e aieea? eieaaaio. ?ioiia a?aeiia?aeue o aaa?oieo c aanoaoe?eiith a?ia?oaic??th ? c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino? oa?aeoa?eco?oueny cieaeaiiyi aaniethoii? ? a?aeiinii? e?eueeino? O-e?ioioeeo?a (CD3), ?o oaeia?ii? noaiiioeyoe?? (CD4) ? a?aeiinii? e?eueeino? O-noi?ani??a/oeeoioiene/ieo ee?oei (CD8). Aeey i?ciueiai aanoico oa?aeoa?i? oaeiae ci?ie a oaoiieaoeaioa?iiio eiiieaen?, eio?? ae?aaeathoueny a cieaeaii? eiioeaio?aoe?? ano??ieo ? ieaoeaioa?iiai eaeoiaaio o 36,5 % ae?iie c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino? oa ci?ie a na?oeaa?e ae?yeueiino? ieiaea o aeaeyae? cieaeaiiy aaea?/? /anoioe ieoo?aeo inoeeeyoe?e oa aiie?ooaee aenaea?aoe?e, a oaeiae iiyaa aeaoeaea?aoe?e aei 3,6(0,5 ? a?eueoa. Aeeth/aiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaenio oa?ai?th i?ciueiai aanoico ia? ae?aaeaiee iiceoeaiee aieea ia an? iieacieee aiiainoaco, ye? aea/aeeny. Ai?no caaaeueiiai a?eea a ne?iaaooe? e?ia? ii?iae?co?oueny o 98,2 % aaa?oieo c aanoaoe?eiith a?ia?oaic??th ? o 76,1 % ae?iie c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?. Niinoa??aa?oueny ii?iae?caoe?y eiioeaio?aoe?? aeueaoi?i?a, (-aeiaoe?i?a, ??aiy e?aaoeieio ? oieanoa?eio a ne?iaaooe? e?ia?, eiioeaio?aoe?? AnAO ? eoaeii? oinoaoace. Iaia?aiiee aacia?a?aiee ieaciaoa?ac ni?ey? i?aeaeuaiith e?eueeino? o?iiaioeeo?a, ii?iae?co? iieacieee o?iiaiaeanoia?aie oa ?iaeaen o?iiaiieanoe/iiai iioaioe?aeo, cieaeo? aa?aaaoe?ei? aeanoeaino? o?iiaioeeo?a, i?eaiaeeoue aei ii?iae?caoe?? ai?noo o?a?eiiaaio o 96,3 % ae?iie c aanoaoe?eiith a?ia?oaic??th ? o 86,7 % — c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?. Aeei?enoaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaeniiio e?eoaaii? i?ciueiai aanoico ni?ey? i?aeaeuaiith ai?noo O-ee?oei (NAe3) o 95,3 % ae?iie c eaaeei ia?aa?aii aeaiiai oneeaaeiaiiy aaa?oiino? oa o 88,5 % — c i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino?, a oaeiae e?eueeino? O-oaeia??a/?iaeoeoi??a (NAe4) ? eiioeaio?aoe?? O-noi?ani??a/oeeoi-oiene/ieo ee?oei (NAe8), ui a e?ioeaaiio ?acoeueoao? ii?iae?co? ooieoe?iioaaiiy aoaeoeaieo eaiie ?ioi?oaoo. ?ic?iaeaia noaia ? ?aaeei i?iaaaeaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaeni?e oa?ai?? i?ciueiai aanoico iiceoeaii aieeaa? ia caaaeueiee noai ae?iee, ia?aa?a aaa?oiino?, iieia?a, noai ieiaea ? iiaiia?iaeaeaiiai, ni?ey? ciaioaiith oyaeeeo oi?i oeueiai oneeaaeiaiiy, i?ieiiaaoe?? aaa?oiino?. Aeniea aoaeoeai?noue ?ic?iaeaiiai eiiieaeno oa?ai?? aeicaiey? ?aeiiaiaeoaaoe eiai aeey oe?ieiai ai?iaaaeaeaiiy a i?aeoeeo ioi?iie caei?ia'y. I?aeoe/i? ?aeiiaiaeaoe?? Aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy aaa?oieo c i?ci?i aanoicii, cieaeaiiy iia?/ii? ae?? e?ea?nueeeo i?aia?ao?a ia i?aai?ci iaoa?? oa ieiaea iieacaii aeeth/aiiy a eiiieaenio oa?ai?th aeaii? iaoieia?? iaia?aiiiai aacia?a?aiiai ieaciaoa?aco. Iieacaiiyie aeey i?iaaaeaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco ? a?aenooi?noue aoaeoo a?ae iaaeeeaiaioicii? oa?ai?? o aaa?oieo c aanoaoe?eiith a?ia?oaic??th oa i?aaeeaiin??th na?aaeiueiai nooiaiy oyaeeino? ia i?ioyc? 7 ? a?eueoa aei?a, a oaeiae a?iii?ioa?iai?y oa a?iiaeueaoi?iai?y, a?ia?-(-aeiaoe?iai?y, a?ia?iao???i?y ? a?ia?eaeueoe??i?y ia oii? a?ia?eae??i??, i?aeaeuaiiy eiioeaio?aoe?? AeAO (aei 46,7 4,7 Iae/e ? aeua), AnAO aei 451,6(5,4 Iae/e oa eoaeii? oinoaoace aei 402,0(19,0 Iae/e. E?eoa??yie i?ecia/aiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco ? i?aeaeuaiiy eiioeaio?aoe?? o?a?eiiaaio aei 5,6(0,5 a/e ? a?eueoa, ?iaeaeno o?iiaiieanoe/iiai iioaioe?aeo aei 27,2(2,1 o.i. ? aeua, i?aeaeuaiiy aa?aaaoe?eieo aeanoeainoae o?iiaioeeo?a, a oaeiae ca?eueoaiiy ?ioii?aaoeyoi?iiai ni?aa?aeiioaiiy NAe4/NAe8 a?eueoa ca 1,28(0,08 aai ??cea eiai cieaeaiiy, iecueeee ??aaiue ai?iii?a oaoi-ieaoeaioa?iiai eiiieaeno oa ci?ie a na?oeaa?e ae?yeueiino? ieiaea o aeaeyae? cieaeaiiy aaea?/? /anoioe ieoo?aeo inoeeeyoe?e oa aiie?ooaee aenaea?aoe?e, a oaeiae iiyaa aeaoeaea?aoe?e aei 3,6(0,5 ? a?eueoa. I?e e?eoaaii? aaa?oieo c i?ci?i aanoicii iaiao?aeii i?iaaaeaiiy eo?no iaia?aiiiai aacia?a?aiiai ieaciaoa?aco c o?ueio i?ioeaaeo?, ?ioa?aaeii 2(5 aei?a. Ieaciiaa cai?uaiiy iiaeiii iaia'yceiai aeeth/aoe a?eeia? ?ic/eie oa ?aieia?/ii aeoeai? eiei?aee, ni?aa?aeiioaiiy aeaaaeaii? ieacie aei ieaciicai?uoaa/?a — 1 : 1,4. I?iaaaeaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco o aaa?oieo c i?ci?i aanoicii ne?ae aeeiioaaoe a ?ci- oa a?ia?aieai?/iiio ?aaeei?, aeey oeueiai aenooc?? e?ia? iiaeiii iiia?aaeaeoaaoe aaaaeaiiy aaia?eio a aeic? 2,5(7,5 oen. Iae. a caeaaeiino? a?ae iieaciee?a aaiinoac?ia?aie. I?ioeiieacaiiyie aeey i?iaaaeaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco o aaa?oieo c i?ci?i aanoicii ?: a?iieiaaoeyoe?y ca aeaieie aaiinoac?ia?aie, aea?a?/i? ?aaeoe?? ia a?eeia? ? eiei?aei? ?ic/eie. I?e o?eaaeiio ia?aa?ao i?ciueiai aanoico, yeee ia i?aeaea?oueny eiiieaeni?e oa?ai?? c aeeth/aiiyi iaia?aiiiai aacia?a?aiiai ieaciaoa?aco, iieacaii ia?aae/ania ?ic?iaeaeaiiy. Nienie ?ia?o, iioae?eiaaieo ii oai? aeena?oaoe?? Aeeyiea iai?a?uaiiai iaia?aiiiai ieaciaoa?aca ia eiioiiaaiinoaceieiae/aneea acaeiiaeaenoaey o aa?aiaiiuo n IIA-aanoicii // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee. — 1998. — O. 3, ? 2. — N. 24(28 (ni?aaao. *aeea A.E., Aeaieia O.I.) Aieea aacia?a?aiiai iaia?aiiiai ieaciaoa?aco ia ?ioiiaaiinoac?ieia?/i? aca?iica’ycee o aaa?oieo c i?aaeeaiin??th // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. — 1999. — Aei. 8. — N. 31(34. Aeai?/a aeeth/aiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco aei eiiieaenii? oa?ai?? i?aaeeaiin?? // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu. — 1999. — O. 8, ? 1. — N. 147(149. Ni?aoeeiiiay aeaoieneeaoeey o aa?aiaiiuo n iicaeieie oieneeicaie // Iaoa?eaeu 53-e eoiaiaie nooaeai/aneie iao/iie eiioa?aioeee, 13(15 iay 1991. — Aeiiaoee, 1991. — N. 149(150 (ni?aaao. O?oa/aieiia A.E., Iaca?ia A.A.). E aii?ino eiiiuethoa?ecaoeee e?eoe/aneeo ninoiyiee a aeooa?noaa // Iaoa?eaeu 53-e eoiaiaie nooaeai/aneie iao/iie eiioa?aioeee, 13(15 iay 1991. — Aeiiaoee, 1991. — N. 150(151 (ni?aaao. O?oa/aieiia A.E., Iaca?ia A.A.). Iiuo e ia?niaeoeau i?eiaiaiey yooa?aioiuo iaoiaeia oa?aiee a aeooa?noaa // Aeooaeueiua i?iaeaiu iaaeeoeeiu Aeiiaanna: Oac. aeiee. iao/. eiio. — Aeiiaoee, 1996. — N. 133 (ni?aaao. Einoaiei A.N., Ieo?ioei I.A., ?acie/aiei A.A.). Opportunities of plasmapheresis in pragnants with accompanying obstetrical and extragenital pathologyIntensive care medicine (official Journal of the European Society of intensive Care Medicine and the European Society of Pediatric intensive Care) // 8th European Congress of intensive Care Medicine. — 1995. — Vol. 21, Suppl. 1. — P. 181 (ni?aaao. Kostenko V., Kabanko T., Galalu S., Shramenko K.). Iia? i?aeoiaee aei aeei?enoaiiy aoa?aioieo iaoiae?a oa?ai?? a aeooa?nueei-a?iaeieia?/i?e i?aeoeoe? // X c‘?cae aeooa??a-a?iaeieia?a Oe?a?ie. — Iaeana, 1996. — N. 65 (ni?aaao. Aaeaeo N.?., Einoaiei A.N.). AIIOAOe?ss ?aci?/aiei I.A. Aeei?enoaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaeniiio e?eoaaii? i?ci?o aanoic?a. — ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 — aeooa?noai oa a?iaeieia?y. — ?inoeooo iaae?ao???, aeooa?noaa ? a?iaeieia?? AII Oe?a?ie. Ee?a, 1999. ?iaioa i?enay/aia ieoaiiyi aeei?enoaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaeniiio e?eoaaii? i?ci?o aanoic?a. Aea/ai? iieacieee aaiinoaco, ?ioiii? a?aeiia?ae?, ai?iiiaeueiiai, a?io?i?/iiai i?io?e?a, oaoiieaoeaioa?iiai eiiieaeno, noaio ieiaea ca aeaieie ea?ae?ioieia?ao?? aei ? i?ney i?iaaaeaiiy eo?n?a iaia?aiiiai aacia?a?aiiai ieaciaoa?aco. ?ic?iaeaia ? iaoeiai iaa?oioiaaia noaia aeei?enoaiiy iaia?aiiiai aacia?a?aiiai ieaciaoa?aco a eiiieaeniiio e?eoaaii? aaa?oieo c i?ci?i aanoicii, yea aeicaiey? cieceoe /anoioo aeooa?nueeeo ? ia?eiaoaeueieo oneeaaeiaiue i?e oe?e iaoieia??, iieacaia ?? aoaeoeai?noue. Eeth/ia? neiaa: i?ci?e aanoic, ieaciaoa?ac, aaiinoac?ieia?/i? iieacieee. AIIIOAOeEss ?acie/aiei I.A. I?eiaiaiea iai?a?uaiiai iaia?aiiiai ieaciaoa?aca a eiiieaeniii ea/aiee iicaeieo aanoicia. — ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 — aeooa?noai e aeiaeieiaey. — Einoeooo iaaeeao?ee, aeooa?noaa e aeiaeieiaee AII Oe?aeiu. Eeaa, 1999. ?aaioa iinayuaia aii?inai i?eiaiaiey iai?a?uaiiai iaia?aiiiai ieaciaoa?aca a eiiieaeniii ea/aiee iicaeieo aanoicia. Oeaeueth iao/iie ?aaiou yaeyaony ?ac?aaioea iao/ii iainiiaaiiie noaiu ea/aiey iicaeieo aanoicia iooai aeeooa?aioee?iaaiiiai i?eiaiaiey iaia?aiiiai iai?a?uaiiai ieaciaoa?aca aeey nieaeaiey ia?eiaoaeueiie caaieaaaaiinoe e nia?oiinoe. Aeey ?aoaiey iinoaaeaiiie oeaee ianeaaeiaaii 176 aa?aiaiiuo a n?iea 25-36 iaaeaeue, ec ieo 107 aa?aiaiiuo n a?oa?eaeueiie aeia?oaiceae, 43 – n i?ayeeaiineae n?aaeiae noaiaie oyaeanoe e 26 aeaiuei n oeceieiae/aneei oa/aieai aa?aiaiiinoe (eiio?ieueiay a?oiia). 76 aeaiuei iieo/aee ?aeiiaiaeiaaiiue iaie eiiieaen oa?aiee n aeeth/aieai IA (iniiaiay a?oiia) e 74 - i?eaea?aeeaaeenue o?aaeeoeeiiiie oa?aiee niaeanii iaoiaee/aneei ?aeiiaiaeaoeeyi IC Oe?aeiu (1997). Eco/aiu iieacaoaee aaiinoaca, eiioiiiai ioaaoa, ai?iiiaeueiiai, aeioeie/aneiai, oaoiieaoeaioa?iiai eiiieaena, ninoiyiey ieiaea ii aeaiiui ea?aeeioieia?aoee aei e iinea eo?nia i?iaaaeaiey iai?a?uaiiai iaia?aiiiai ieaciaoa?aca. ?acoeueoaou i?iaaaeaiiuo enneaaeiaaiee naeaeaoaeuenoaotho i iai?yaeaiee ?acee/iuo nenoai aiiainoaca o aa?aiaiiuo n i?iyaeaieyie iicaeiaai aanoica. Nieaeaaony o?iaaiue iauaai aaeea, aeueaoieiiaie o?aeoeee e iiauoaaony eiioeaio?aoeey AEO, ANO e uaei/iie oinoaoacu (? < 0,05). Ia?anoaiea noaiaie oyaeanoe iicaeiaai aanoica nii?iaiaeaeaaony eciaiaieai eiaaoeioea?eiieeoe/aneeo iniaaiiinoae e?iae a iai?aaeaiee aeia?eiaaoeyoeee. Eciaiaiea a o?iiaioeeoa?iii caaia i?iyaeyaony aeinoiaa?iui oiaiueoaieai eiee/anoaa o?iiaioeeoia, /oi iaoneiaeaii, ia iao acaeyae, iiauoaiiui eniieueciaaieai eo a ia?eoa?a/aneii e?iaiia?auaiee (iniaaiii a iaoi/ii-ieaoeaioa?iie ciia). Yoi, a naith i/a?aaeue, niinianoaoao aua?ino a e?iayiia ?onei iieiaeuo oi?i o?iiaioeeoia. Eciaiyaony eo ooieoeeiiaeueiay aeoeaiinoue, iniaaiii i?e i?ayeeaiinee n?aaeiae noaiaie oyaeanoe. Oae, eiaeaen AAeO-eiaeooee?iaaiiie aa?aaaoeee o?iiaioeeoia ninoaaeyao o aeaiiiai eiioeiaaioa aieueiuo 51,1 % ( o caei?iauo – 44,4 %, ?<0,05). Aeey iicaeiaai aanoica oa?aeoa?iu eciaiaiey a nenoaia eiioiiaaiaca. Ioia/aaony nieaeaiea aaniethoiiai e ioiineoaeueiiai eiee/anoaa O-eeioioeeoia, eo oaeia?iie noaiiioeyoeee (NAe4) e ioiineoaeueiiai eiee/anoaa O-noi?anni?ia oeeoioiene/aneeo eeaoie (NAe8 ). Niioiioaiea O-oaeia?u/O-noi?anni?u iiauoaaony aei 1,93 i?e aanoaoeeiiiie aeia?oaicee e iaaeaao aei 1,32 – i?e n?aaeiai oa/aiee i?ayeeaiinee. Iaie iieo/aiu aeaiiua i nieaeaiee ai?iiiia oaoi-ieaoeaioa?iiai eiiieaena o 36,5 % aieueiuo n aanoicaie. I?eieiay ai aieiaiea auoaeceiaeaiiia, iaoiaaiaoe/anee iainiiaaiiui yaeeinue aeeth/aiea a eiiieaenioth oa?aieth iicaeiaai aanoica iai?a?uaiiai iaia?aiiiai ieaciaoa?aca, ea/aaiia aicaeaenoaea eioi?iai ?aaeecoaony aeaaiaea?y aeaceioieneeaoeeiiiiio, eiioiiei?eae?othuaio e aeeooociiio iaoaieciai. Oaeia iiiaieiiiiiaioiia aeaenoaea iineaaeiaai ieacaei au?aaeaiiia iieiaeeoaeueiia aeeyiea ia ana eco/aaiua iieacaoaee. ?ac?aaioaiiay e iao/ii iainiiaaiay noaia i?eiaiaiey iai?a?uaiiai iaia?aiiiai ieaciaoa?aca a eiiieaeniii ea/aiee aa?aiaiiuo n iicaeiei aanoicii iicaieeea oaeaea nieceoue /anoioo aeooa?neeo e ia?eiaoaeueiuo ineiaeiaiee i?e yoie iaoieiaee. Eeth/aaua neiaa: iicaeiee aanoic, ieaciaoa?ac, aaiinoaceieiae/aneea iieacaoaee Summary Reznichenko N.A. Application of the continuos membrane plasmapheresis for the complex treatment of preeclampsia. — Manuscript. Dissertation of the scientific degree of the candidate of medical sciences in specialty 14.01.01 — Obstetrics and Gynecology. Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences of Ukraine. Kiev, 1999. In present work effectiveness of the continuos membrane plasmaferesis for the treatment of preeclampsia was investigated. Changes in immune response, heamostasis endocrine system, fetoplacental complex and cardiotocogram patterns evaluated before and after therapy. Scientific evidence based protocol for the treatment of preeclampsia by continuos membrane plasmaferesis has been developed. This protocol allows to reduce the incidence of perinatal and obstetrical complications in this pathology. The efficacy of this protocol is being proved. Key words: preeclampsia, plasmaferesis, heamostasiologic indices Ia?ae?e oiiaieo nei?i/aiue AnAO - ania?oaoaai?iio?ainoa?ace AeAO - aeai?iai?iio?ainoa?ace AO ??? - aioeo?iia?i ??? NAe4 - O-oaeia?e NAe8 - O-noi?ani?e EOA - ea?ae?ioieia?ao?y EO - eoaeia oinoaoaca IOeE - ia'?i oee?eoethth/i? e?ia? IA - ieaciaoa?ac OAO - o?iia?i-aioeo?iia?i

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