Морфофункціональна та математична оцінка стану жовчного русла в залежності від виду біліодигестивного сполучення (експериментальне дослідження): Автор

I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OA?III?EUeNUeEA AeA?AEAAIA IAAeE*IA

AEAAeAI?ss ?I. ?. AI?AA*AANUeEIAI

IEUeOIIssE Ieaenaiae? Ieaenaiae?iae/

OAeE 611-018.5(083.3):611.361:616-089.86

ii?oiooieoe?iiaeueia oa iaoaiaoe/ia ioe?iea noaio aeia/iiai ?onea a
caeaaeiino? a?ae aeaeo a?e?iaeeaanoeaiiai niieo/aiiy

(aenia?eiaioaeueia aeine?aeaeaiiy)

14.03.01 – ii?iaeueia aiaoii?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaith

eaiaeeaeaoa iaaee/ieo iaoe

Oa?iii?eue – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia O A?iieoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I. Ie?iaiaa IIC Oe?a?ie

IAOEIAEE EA??AIEE:

aeieoi? iaaee/ieo iaoe, i?ioani? EINOTHE A?eai??e sseiae/, caa?aeoaa/
eaoaae?e oiiia?ao?/ii? aiaoii?? oa iia?aoeaii? o??o?a?? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I. Ie?iaiaa IIC Oe?a?ie

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, i?ioani? AIA?EE ?aai ?aaiiae/, caa?aeoaa/
eaoaae?e ii?iaeueii? aiaoii?? Ee?anueeiai iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i. I. Aiaiiieueoey

aeieoi? iaaee/ieo iaoe, i?ioani? AAEAeA ?iiai Eineiiae/, caa?aeoaa/
eaoaae?e oiiia?ao?/ii? aiaoii?? oa iia?aoeaii? o??o?a?? Oa?iii?euenueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?. Ai?aa/aanueeiai

I?IA?AeIA ONOAIIAA:

?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y

Eaoaae?a ii?iaeueii? aiaoii??

Caoeno a?aeaoaeaoueny “ 22 n?/iy ” 1999 ?. i 12-00 aiaeei?

ia can?aeaii? niaoe?ae?ciaaii? A/aii? ?aaee E 58.601.01. i?e
Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai?? ?i. ?. Ai?aa/aanueeiai
IIC Oe?a?ie.

Aae?ana: 280001, i. Oa?iii?eue, Iaeaeai Aie?, 1.

C aeenna?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?iii?euenueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.Ai?aa/aanueeiai IIC Oe?a?ie
(280001, i.Oa?iii?eue, Iaeaeai Aie?, 1)

Aaoi?aoa?ao ?ic?neaii “ 18 a?oaeiy ” 1998 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

A/aii? ?aaee, ae.i.i., i?ioani? E?o I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

AEOOAEUeI?NOUe OAIE. I?ia?aeio ?ieue a ?ino?oiaioaeue-i?e ae?aaiinoeoe?
iai?io?aeiino? aeia/iaea?aeieo oeyo?a ii i?aao caeia? eiio?anoia
?aioaaiia?ao?y (A.A.Aeiia?aaeia, 1977; A.A.Ei?ieaa, 1990; G.Ghilardi et
al., 1989). I?ioa aeai?, io?eiai? iath aeineoue /anoi noia?a/eea? ? ia
caaaeaee a??ia?aei?. Iia’ycaii oea c oei, ui ieiueiia a?aeia?aaeaiiy ia
iaia?? ia iiaea aooe a?aeiia?aeiei a?aeia?aaeaiiyi i?inoi?iai? aoaeiae.
Oaeiae aeineoue iaei aeine?aeaeaiue, o yeeo ae aaeiny ni?anoaaeaiiy ci?i
a?ae?iaeeiai?ee aeia/? oa i?inoi?iaiai noaio aeia/ieo i?ioie
(I.A.Eo?eao, 1989; A.A.Oeae e niaa. 1989, 1994; I.A.Neaaee, 1995). E??i
oiai, io?eiai? aeaieie aaoi?aie ?acoeueoaoe oa?aeoa?ecoaaee i?inoi?iaee
noai eeoa ie?aii acyoiai ii?yaeeo aeia/ieo i?ioie.

*?eueia i?noea na?aae niinia?a o??o?a?/iiai e?eoaaiiy iai?io?aei?no?
aeia/iiai ?onea caeia? oi?ioaaiiy ooo/iiai niieo/aiiy i?ae caaaeueiith
aeia/iith i?ioieith ? oiieith eeoeith. Aeoaea aaaeeeai noai?thaaoe
a?aoetheni? aianoiiice, ye? aeicaieeee a i?e caa?aaeaii?
aiaoiii-ooieoe?iiaeueii? ?cieyoe?? aeia/iiai ?onea a?ae eeoeiaiai o?aeoo
caiia?aaoe iiya? aeno?aeiiai oieaia?iaaiaoeoo (E.A.Eioia, 1982;
ss.Ae.Aeoaaneee, 1988; Oaeeiia N.A., 1991; A.Chlumska et al., 1986 ).
I?ioa /a?ac a?aenooi?noue iaae?eiiai caie?ath/iai iaoai?cio ?nioth/?
a?aoetheni? aianoiiice ia io?eiaee oe?ieiai canoinoaaiiy o e?eoaaii?
a?e?a?ii? iaoieia??. Oiio ?ic?iaea iiaeo a?aoethenieo aianoiiic?a, ye? a
o iaea?eueo?e i??? caa??aaee aiaoiii-o?c?ieia?/io iniiao ooieoe?iioaaiiy
aeaiiai a?aeae?eo, a oaeiae noai?thaaee a iaiao?aei? oiiae aeey
cai?ioiueiai ?icaeoeo iaoieia?/ieo ci?i a i?aai?ci? ? iaaecae/aeii
aeooaeueiith.

Iaaiith i??ith ia nueiaiaei?oi?e aeaiue caeeoa?oueny a?aee?eoei ieoaiiy
ia?ea?a ia?aaoaeiae aeia/iiai ?onea i?e iaoo?aoe?eiiio oieanoac? oa
i?ney eiai ei?aeoe?? (I.A.Ieeiiia, 1981; A.A.Aeiia?aaeia, 1985;
A.A.Oaeeiia, 1990; I.A.Neaaee, 1995; T.Porolla, 1985; M.Staritz, 1986).
Ae??oaiiy aeaiiai ieoaiiy aeiiiiiaea iie?aueoe ae?aaiinoeeo oa e?eoaaiiy
aeaii? iaoieia??.

CA’ssCIE ?IAIOE C IAOEIAEIE I?IA?AIAIE, IEAIAIE, OAIAIE.

Aeeiiai? aeine?aeaeaiiy ? /anoeiith iaoeiai? ?iaioe eaoaae?e
oiiia?ao?/ii? aiaoii?? oa iia?aoeaii? o??o?a?? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?.Ie?iaiaa
«Ii?oiooieoe?iiaeueia iaa?oiooaaiiy iiaeo niinia?a o??o?a?/iiai
e?eoaaiiy caoai?thaaiue i?aai?a /a?aaii? ii?iaeieie a aenia?eiaio?», N
aea?ae?a?no?aoe?? 0196 U 004913. Oaia aeena?oaoe?? aoea caoaa?aeaeaia ia
can?aeaii? A/aii? ?aaee AAeIO 18 ea?oiy 1996 ?ieo (i?ioieie can?aeaiiy N
6).

IAOA ? CAAeA*? AeINE?AeAEAIIss: ia iniia? ii?oiooieoe?iiaeueieo
aeine?aeaeaiue oa iaoaiaoe/iiai aiae?co i?inoi?iai? aoaeiae aeia/iiai
aea?aaa ?ic?iaeoe iioeiaeueiee aa??aio a?e?iaeeaanoeaiiai niieo/aiiy.

1.Anoaiiaeoe iniaeeaino? i?inoi?iai? aoaeiae aeia/iaea?aeieo oeyo?a ca
oiia ii?ie.

2.?ic?iaeoe iaoiaaiaoe/ii aaeaeaaoio iiaeaeue iecueei? iai?io?aeiino?
aeia/ieo oeyo?a.

3.Aea/eoe aieea ii?oiooieoe?iiaeueiiai noaio aeia/iiai ?onea ia eiai
i?inoi?iai-noa?aiiao?e/io aoaeiao oa ia ?icaeoie aiaeiaaiii?
?ioieneeaoe?? i?aai?cio a caeaaeiino? a?ae aeaeo a?e?iaeeaanoeaiiai
niieo/aiiy.

4.Aeine?aeeoe o ii??aiyeueiiio aniaeo? a?aoethenio ooieoe?th iaea?eueo
aaeeaaieo oieaaeioiaeoiaeaiaeueieo aianoiiic?a (ca niiniaaie
TH?ao-Aeiia?aaeiaa, A?oaanueeiai) ? ca aeaniei niiniaii oa aeaoe ?o
ii?oiooieoe?iiaeueio ioe?ieo.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAO?A.

Ia a?aei?io a?ae ?nioth/eo ?ic?iaeaia i?inoa ? iaoiaaiaoe/ii
iaa?oioiaaia iiaeaeue iai?io?aeiino? aeia/ieo oeyo?a, yea aeaea ciiao
eiiieaenii aeine?aeeoe iaoieia?/i? ci?ie o ii?oiooieoe?iiaeueiiio noai?
aeia/iiai ?onea. Ae?noaei iiaeaeueoiai ?icaeoeo aecia/aiiy ca’yce?a i?ae
ia?aiao?aie a?e?a?ii? a?ia?oaic??, aiaeiaaiii? ?ioiene-eaoe?? oa
ii?oinoa?aiiao?e/iei noaiii aeia/ieo oeyo?a ca oiia ii?ie,
iai?io?aeiino? aeia/iiai ?onea ? ianooiii? ?? o??o?a?/ii? ei?aeoe??.
Iiaeaeueoa aea/aiiy i?inoi?iai-noa?aiiao?e/ii? aoaeiae aeia/iiai aea?aaa
aeicaieeei ?ic?iaeoe eiiieaen e?eoa???a aeey ae?aaiinoeee iaoo?aoe?eiiai
oieanoaco, yeee aeiiiiiaa? i?ine?aeeiaoaaoe cai?ioi?noue iaoieia?/ieo
i?ioean?a i?ney o??o?a?/ii? ei?aeoe??. Cai?iiiiiaaii iiaee ?iaeaen
?ioieneeaoe?? aeey a?eueo aeaoaeueiiai aea/aiiy aiaeiaaiii?
?ioieneeaoe??. ?ic?iaeaii iiaee niin?a oi?ioaaiiy a?e?iaeeaanoeaiiai
aianoiiico, yeee iaae?eii iiia?aaeaeo? ?icaeoie aeno?aeiiai
oeaia?iaaiaoeoo. ?ic?iaeaii iiaee niin?a ?io?aiia?aoe?eiiai aecia/aiiy
ooieoe?iiaeueieo iiaeeeainoae a?aoethenieo aianoiiic?a.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAO?A.

Ia iniia? ca’yce?a a?e?a?ii? a?ia?oaic??, aiaeiaaiii? ?ioieneeaoe?? oa
ii?oinoa?aiiao?e/iiai noaio aeia/iiai ?onea noai?aii ae?aaiinoe/iee
eiiieaen e?eoa???a. Inoai?e aeicaiey? i?iaiicoaaoe iiaeeea? oneeaaeiaiiy
i?e ia?aa?ao ? e?eoaaii? iai?io?aeiino? aeia/ieo oeyo?a. Noai?aiee
a?aoetheniee a?e?iaeeaanoeaiee aianoiiic iiaea oe?iei canoiniaoaaoeny a
o??o?a?? aeia/ieo oeyo?a, ine?eueee iaae?eii caiia?aa? ?icaeoeo
aeno?aeiiai oieaia?oo a i?neyiia?aoe?eiiio ia??iae?. ?ic?iaeaiee iiaee
niin?a aecia/aiiy ooieoe?iiaeueii? ni?iiiaeiino? aianoiiic?a aeicaiey?
nai?/anii onoaaoe iaaeie?ee i?e ?o oi?ioaaii?.

Iaoeia? ?acoeueoaoe aeena?oaoe?? ai?iaaaeaeaii? o i?ia?aio o/aiaiai
i?ioeano oa aeey aeei?enoaiiy o iaoeia?e ?iaio? ia eaoaae?ao iia?aoeaii?
o??o?a?? ? oiiia?ao?/ii? aiaoii??, ii?iaeueii? aiaoii??, iaoieia?/ii?
aiaoii??, a?noieia?? oa aia??ieia??, caaaeueii? o??o?a??,
iaoeiai-aeine?aeiiai oeaio?o A?iieoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

INIAENOEE AIANIE CAeIAOAA*A.

Aaoi?ii naiino?eii aeeiiai? aenia?eiaioaeuei? aeine?aeaeaiiy,
aeaioiaeai? ei??ic?ei?, a?noieia?/i? i?aia?aoe aeia/iaea?aeieo oeyo?a c
?o iiaeaeueoith ii?oiiao???th. ?ic?iaea noa?aiiao?e/iiai aiae?co
i?inoi?iai? aoaeiae aeia/iiai ?onea cae?eniaia i?e aeiiiiic? anenoaioa
eaoaae?e iaaee/ii? o?ceee A?iieoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo Eiaaeue/oea I.I. O ?ic?iaoe? aeanii? iaoiaeeee
aeine?aeaeaiiy ooieoe?? eeaiaiieo aia?ao?a, niiniao a?aoetheniiai
a?e?iaeeaanoeaiiai aianoiiico a?aee o/anoue ni?a?ia?oieee eaoaae?e
oiiia?ao?/ii? aiaoii?? oa iia?aoeaii? o??o?a?? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. Naiino?eii aeeiiaia noaoenoe/ia
ia?iaea iaea?aeaieo oeeo?iaeo aeaieo. Aaoi? a?aa o/anoue o i?iaaaeaii?
i?e?ia?ieia?/ieo aeine?aeaeaiue.

AI?IAAOe?ss ?ACOEUeOAO?A AeENA?OAOe??.

Ca ?acoeueoaoaie aeine?aeaeaiue, ui oa?eoee aei aeena?oaoe??, c?iaeaii
aeiiia?ae? ia 5-e ?anioae?eainuee?e o/aiai-iaoiaee/i?e oa iaoeia?e
eiioa?aioe?? caa?aeoth/eo eaoaae?aie caaaeueii? o??o?a?? iaaeaoc?a
Oe?a?ie (Oa?iii?eue, 1996), ia i?aeia?iaei?e eiioa?aioe?? «Aeooaeuei?
ieoaiiy ii?oieia??» (Oa?iii?eue, 1996), ia
aano?i-oai?nueei-neiaaoeueeiio neiiic?oi? «Oieanoaoe/i? iioeiaeaeaiiy
ia/?iee» (A?ao?neaaa, 1996), ia XIV i?aeia?iaeiiio neiiic?oi? «AEia/i?
eeneioe i?e aaiaoia?e?a?ieo caoai?thaaiiyo» (O?aeao?a, 1996), ia
i?aeia?iaei?e iaoeia?e eiioa?aioe?? «Aeooaeuei? ieoaiiy no/anii?
o??o?a??» (Oaeai?iae, 1997).

Aeena?oaoe?y ai?iaiaaia 29 ea?oiy 1998 ?ieo ia i?aeeaoaae?aeueiiio
can?aeaii? A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.
I.?.Ie?iaiaa.

IOAE?EAOe??.

?acoeueoaoe aeena?oaoe?? iioae?eiaai? o 3 iaoeiaeo aeo?iaeueieo noaooyo,
a 1 ca??ieeo iaoeiaeo i?aoeue, o 4 iaoa??aeao eiioa?aioe?e. Iaea?aeaii 4
aeia?aeee i?i i??i?eoao ia aeiao?ae, 2 iina?ae/aiiy ia
?aoe?iiae?caoi?nueeo i?iiiceoe?th.

NO?OEOO?A OA IA’?I AeENA?OAOe??.

Aeena?oaoe?y neeaaea?oueny c? anooio, iaeyaeo e?oa-?aoo?e, iieno
iaoa??ae?a ? iaoiae?a aeine?aeaeaiiy, /ioe?ueio ?icae?e?a aeanieo
aeine?aeaeaiue, ?icae?eo iaaiai?aiiy ?acoeueoao?a aeanieo
aeine?aeaeaiue, aeniiae?a, nieneo aeei?enoaieo e?oa?aoo?ieo aeaea?ae
(157 i?aoeue ia oe?a?inuee?e ? ?in?enuee?e iiaao ? 92 ia iiaao
aeaeueiueiai ca?oa?aeaey). Aeena?oaoe?y aeeeaaeaia ia 189 noi??ieao
iaoeiiieniiai oaenoo, ?ethno?iaaia 13 oaaeeoeyie oa 48 ?enoieaie.

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy.

Aenia?eiaioaeuei? aeine?aeaeaiiy i?iaaaeaii ia 48 aacii??aeieo niaaeao
ianith a?ae 4 aei 8 ea. A caeaaeiino? a?ae oa?aeoa?o iia?aoeaiiai
ao?o/aiiy an? oaa?eie aoee iiae?eai? ia 5 aenia?eiaioaeueieo a?oi.

Ia?oa a?oia aoea eiio?ieueiith (6 niaae). O oaa?ei ae?oai? a?oie (6
niaae) noai?thaaee iiaeaeue iecueei? iai?io?aeiino? aeia/iiai ?onea.
Aeey oeueiai caaaeueio aeia/io i?ioieo nea?eo?eoaaee ? ia?aa’ycoaaee
oeyoii noana?iciiai iaeeaaeaiiy eenaoiiai oaa. Inoaii?e caoyaoaaee oae,
uia i?ina?o i?ioiee noaiiaea 1 ii. (Iina?ae/aiiy ia paoe?iiae?caoi?nueeo
i?iiiceoe?th N3 a?ae 12.01.98., aeaeaia A?iieoeueeei aea?aeaaiei
iaaee/iei oi?aa?neoaoii ?i. I.?.Ie?iaiaa.) O oaa?ei o?aouei?, /aoaa?oi?,
i’yoi? a?oi (ii 12 oaa?ei ia a?oio) cae?enithaaee e?eoaaiiy 7-aeiaiaiai
iaoo?aoe?eiiai oieanoaco oeyoii oi?ioaaiiy oieaaeioiaeoiaeaiaeueieo
aianoiiic?a ca iaoiaeaie TH?ao-Aeiia?aaeiaa, A?oaanueeiai oa aeanii?
eiino?oeoe??. Ii?oiooieoe?iiaeuei? aeine?aeaeaiiy i?iaiaeeee /a?ac 21 ?
90 ae?a i?ney o??o?a?/ii? ei?aeoe?? iai?io?aeiino? aeia/iiai ?onea.

Niin?a oi?ioaaiiy aioe?aoetheniiai oieaaeioiaeoiaeaiaeueiiai aianoiiico
aeanii? eiino?oeoe?? iieyaa? o oiio, ui ?ic??c na?icii-i’ycaaiai oa?o
aeaaiaaeoeyoeiaei? eeoee i?iaiaeyoue o iiia?a/iiio iai?yieo, a
neeciai-i?aeneeciaiai oa?o — o iicaeiaaeiueiio iai?yieo ? ii iaeaea?
noi?iie a?ae c’?aeiaiiy oi?iothoue iicaeiaaeith neeaaeeo ?c
neeciai-i?aeneeciaiai oa?o aeaaiaaeoeyoeiaei? eeoee. (I??i?eoaoia
??oaiiy Aea?aeiaoaioo Oe?a?ie ia aeiao?ae «Niin?a oi?ioaaiiy
aioe?aoetheniiai aianoiiico» N97104982 a?ae 10.10.1997 ?.)

Aeey i?aiaaeeeaoe?? aeei?enoiaoaaee aioo??oiueii’yciaa aaaaeaiiy 2,5%
?ic/eio ai?iaceio, 1% — ae?iaae?ieo, 0,1% — iaoaoeeio. Aaceniee ia?eic
i?iaiaeeee oeyoii aioo??oiueiieaa?aeueiiai aaaaeaiy 10% ?ic/eio
o?iiaioaeo- iao??th. Aaoaiac?th oaa?ei cae?enithaaee oaeaeeei
aioo??oiueiaaiiei aaaaeaiiyi 10-20 ie 2% ?ic/eio o?iiaioaeo-iao??th.

Aeine?aeaeaiiy iniaeeainoae i?inoi?iai? aoaeiae aeia/iiai aea?aaa
cae?enithaaee oeyoii aiae?co 5 ?io?aiia?aoe?eieo oieaia?ia?ai oai?eo
ethaeae ?c iai?io?aei?noth aeia/ieo oeyo?a, a oaeiae aeaioiaeaieo
ei??ic?eieo i?aia?ao?a aeia/iiai aea?aaa na?aeio?oiii? ia/?iee ethaeae
(5 i?aia?ao?a) oa oaa?ei (ii 5 i?aia?ao?a ia eiaeio a?oio oaa?ei). Ca
aeiiiiiaith aaeioiaiai ieoey?i?e?iiao?a IIA-1-15o
aa??aoe?eii-noaoenoe/ieie iaoiaeaie aecia/aee ae?aiao?e aeia/ieo i?ioie.

Ia oeeo i?aia?aoao aoei anoaiiaeaii, ui iaei??th c iciae i?inoi?iai?
aoaeiae aeia/iaea?aeii? nenoaie niaaee ? ethaeeie ? aneiao?e/i?noue.
Aiia iieyaa? o iaiaeiaeiaiio i?ina?o? a?eie i?ney /a?aiaiai
?icaaeoaeaiiy — ae?aiao? iaei??? a?eee caaaeaee a?eueoee ca ae?aiao?
ae?oai?. Oiio ie aecia/aee na?aaei? ae?aiao?e a?eie a?eueoiai ? iaioiai
i?ina?o?a o eiaeiiio ii?yaeeo. Ie i?eionoeee, ui ciaioaiiy na?aaei?o
ae?aiao??a a?eie aeia/iiai aea?aaa a?ae ai??o ia/?iee aei eiai ia?eoa???
a?aeaoaa?oueny ca aeniiiaioe?eiith caeaaei?noth. C iaoith aecia/aiiy
i?aaii??iino? aeei?enoaiiy ooieoe?? D=e-kz+b (D- ae?aiao? i?ioiee a
ii?yaeeo a?eie z, k -oaeaee?noue ci?ie na?aaei?o ae?aiao??a, b —
eiaa?eoi ae?aiao?o i?ioiee i?e z=0, e — aeniiiaioe?eia eiinoaioa)
noiniaii i?inoi?iai? aoaeiae aeia/iiai aea?aaa aenia?eiaioaeueii
ciaeaeai? na?aaei? ae?aiao?e i?ioie iaioiai oa a?eueoiai i?ina?o?a
eiaeiiai ei??ic?eiiai i?aia?aoo ii??aithaaeenue ?c oai?aoe/ii
ae?aooaaieie ca aeaiith oi?ioeith. Ia?aiao?e k ? b ae?aoiaoaaee ie?aii
aeey i?ioie iaioiai ( k1, b1) ? a?eueoiai (k2, b2) i?ina?o?a ianooiiei
/eiii:

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???????????yyy????.????1?????? ??????? @
???&??yyyy?????AyyyAyyya?????? ???&?
?MathType??a????&??yyyy???????????????????†???????????????????????
????

aea — noia; z? –

on? a?aoiaai? ii?yaeee; lnD? — iaoo?aeueiee eiaa?eoi on?o na?aaei?o
ae?aiao??a i?ioie a?aoiaaieo ii?yaee?a; n — e?euee?noue a?aoiaaieo
ii?yaee?a.

E??i oiai, aecia/aee eiao?oe??io aneiao?e/iino?, ye ni?aa?aeiioaiiy
oaeaeeinoae ci?ie na?aaei?o ae?aiao??a i?ioie iaioeo i?ina?o?a aei
a?eueoeo:

Ka = k1 / k2,

aea Ka — eiao?oe??io aneiao?e/iino?, k1 — oaeaee?noue ci?ie na?aaei?o
ae?aiao??a i?ioie iaioeo i?ina?o?a, k2 — oaeaee?noue ci?ie na?aaei?o
ae?aiao??a i?ioie a?eueoeo i?ina?o?a.

Ia iniia? aeei?enoaiiy oeeo noa?aiiao?e/ieo eiinoaio aoei ?ic?iaeaii
aeaniee niin?a ae?aaiinoeee iaoo?aoe?eiiai oieanoaco (I??i?eoaoia
??oaiiy Aea?aeiaoaioo Oe?a?ie ia aeiao?ae «Niin?a ae?aaiinoeee
iaoo?aoe?eiiai oieanoaco» N97104983 a?ae 10.10.1997 ?.).

Ioe?ieo ii?oieia?/iiai noaio aianoiiico, aeia/ieo i?ioie ? ia?aio?ie
ia/?iee i?iaiaeeee ia iniia? a?noieia?/iiai aeine?aeaeaiiy. C oe??th
iaoith oeaieie o?e-noaaee a 10% ?ic/ei? ii?iaeueiiai oi?iae?io, caeeaaee
o ia?ao?iia? aeiee. C??ce oiaueiith 5 -7 iei oa?aoaaee
aaiaoienee?i-aiceiii ? ca aai-A?cii.

Aecia/aiiy iieaciee?a a?e?iaeeiai?ee i?iaiaeeeiny ca iaoiaeii
A.A.Aeiia?aaeiaa (1972). I?e aei??thaaii? oeneo o ai??oi?e aai? aia?aoii
Aaeueaeiaia nenoaio o?oaie caiiaithaaee 0,85% ?ic/eiii oei?eaeo iao??th
c aaia?eiii (2500 IA ia 2000 ie ?ic/eio). Aioo??oiueiaeoiaeaiaeueiee
oene aecia/aee ca iaoiaeii «a?aee?eoiai eaoaoa?a» aia?aoii Aaeueaeiaia.

Aea/aiiy iaoai?/ii? i?oeiino? oa?a oieaaeioiaeoiaeaiaeueiiai aianoiiico
aeeiioaaee iaoiaeii iiaaiii?an??. Aecia/aiiy ooieoe?iiaeueii?
ni?iiiaeiino? noi?iiaaieo aianoiiic?a aeeiioaaee ca aeaniei iaoiaeii,
eio?ee iieyaaa o ?iciianthaeaeaii? eiio?anoii? ?a/iaeie ii eeooe? i?ae
ae??th ?iioeueniiai aeaeo?e/iiai no?oio ii iaeaeaa aiee a?ae aianoiiico
c iaeii/aniith ?a?no?aoe??th oeneo o caaaeuei?e aeia/i?e i?ioioe?.
(I??i?eoaoia ??oaiiy Aea?aeiaoaioo Oe?a?ie ia aeiao?ae «Niin?a
aecia/aiiy ooieoe?iiaeueii? ni?iiiaeiino? aioe?aoethenieo aianoiiic?a»
N97104981 a?ae 10.10.1997 ?.)

Nooi?iue ae?aaeaiino? aeiaoyieoe? ioe?ithaaany ia iniia? aecia/aiiy
ai?noo caaaeueiiai a?e??oa?io o ne?iaaooe? e?ia? ca iaoiaeii ?iae?aoeea.
Aecia/aiiy eeneioii-eoaeiiai noaio aeia/? i?iaiaeeee ca aeiiiiiaith
aia?aoo «EEAE-2».

Eaai?aoi?ia aea/aiiy ae?aaeaiino? aiaeiaaiii? ?ioieneeaoe?? (A?)
i?iaiaeeeiny ia iniia? aecia/aiiy eaeeioeeoa?iiai ?iaeaeno ?ioieneeaoe??
(E??) ca oi?ioeith ss.ss.Eaeueo-Eaeeoa (1941) o aeani?e iiaeeo?eaoe??
(iina?ae/aiiy ia paoe?iiae?caoi?nueeo i?iiiceoe?th N4 a?ae 12.01.98.,
aeaeaia A?iieoeueeei aea?aeaaiei iaaee/iei oi?aa?neoaoii ?i.
I.?.Ie?iaiaa), ??aiy iieaeoe na?aaeiuei? iane (INI) o ne?iaaooe? e?ia?
ca iaoiaeii I.E.Aaa?eaeyi (1985), ni?aoe?eii? cae?aiino? a?eo?ioeeo?a
(NCA) ca iaoiaeii A.A.Oiaaeaa?aa (1988). C iaoith a?eueo aeaoaeueiiai
aea/aiiy A? i?e oieanoac? oa ioe?iee aoaeoeaiino? canoiniaaieo iaie
e?eoaaeueieo caoiae?a cai?iiiiiaaii aeei?enoaiiy aeiaeaoeiaiai ?iaeaeno
— ne?iaaoeia?eo?ioeeoa?iiai ?iaeaeno ?ioieneeaoe?? (NA??). Aaee/eia
?iaeaeno aei??aith? a?aeiioaiith ??aiy iieaeoe na?aaeiuei? iane aei
??aiy ni?aoe?eii? cae?aiino? a?eo?ioeeo?a. (I??i?eoaoia ??oaiiy
Aea?aeiaoaioo Oe?a?ie ia aeiao?ae «Niin?a aecia/aiiy aiaeiaaiii?
?ioieneeaoe?? i?aai?cio» N95020681 a?ae 15.02.1995 ?.)

Aeey aeyaeaiiy caoaeiee?a caiaeueiiai i?ioeano o aeia/ieo oeyoao
i?iaiaeeee i?e?ia?ieia?/ia aeine?aeaeaiiy aeia/?, aeeiioth/e aen?aaiiy
?? ?icaaaeaiue ia iiaeeai? na?aaeiaeua c iiaeaeueoei aeae?eaiiyi /enoeo
eoeueoo? aaeoa??e ? ?o ?aeaioeo?eaoe??.

Noaoenoe/ia ia?iaea an?o iaea?aeaieo oeeo?iaeo aeaieo i?iaiaeeee ca
aeiiiiiaith i?ia?aie «Stat», a iaoaiaoe/io oa a?ao?/io ia?iaeo aeaieo
ii?oiiao??? aeia/ieo i?ioie ca aeiiiiiaith i?ia?aie «Quattro Pro» ia
eiii’thoa?? IBM PC-386.

Ii?oiooieoe?iiaeueia oa?aeoa?enoeea aeia/ieo oeyo?a ca oiia ii?ie oa
iecueei? iai?io?aeiino? aeia/iiai ?onea

Ii?oiiao?e/iee oa iaoaiaoe/iee aiae?c iieacaa, ui iecueeee a?aenioie
(aei 1%) a?aeoeeaiiy oai?aoe/ii ciaeaeaieo aaee/ei ae?aiao??a i?ioie
(Dt) ca oi?ioeith D=e–kz+b a?ae aenia?eiaioaeueii aei??yieo (De) ia
ei??ic?eieo i?aia?aoao i?aeoaa?aeaeo? aeniiiaioe?eiee oa?aeoa?
i?inoi?iai? aoaeiae aeia/iiai aea?aaa ethaeeie. Noa?aiiao?e/i? ia?aiao?e
b1 (i?eaeecii 2,307) ? b2 (i?eaeecii 2,036) ia aoee noaeeie ? caeaaeaee
a?ae ?ici???a ia/?iee. Ia?aiao?e k1(-0,6350,004) ? k2(-0,3640,004) ia
caeaaeaee a?ae ?ici?-??a ia/?iee, a eiao?oe??io aneiao?e/iino? (Ka)
aei??aith-aaa 1,7450,028.

Aiaeia?/i? aeai? iaie io?eiai? i?e aiae?c? ei??ic?eieo i?aia?ao?a
aeia/iiai aea?aaa niaaee. Ne?ae caoaaaeeoe, ui cia/aiiy ia?aiao??a k1,
k2, Ka aoee oaeeie ye o ethaeeie.

I?e aiae?c? oieaia?ia?ai ethaeae c iecueeith iai?io?aei?noth aeia/iiai
?onea ie niinoa??aaee a?eueo cia/ia ?icoe?aiiy i?ioie ii/aoeiaeo
ii?yaee?a, i?ae e?ioeaaeo; a?eueo cia/ia ?icoe?aiiy i?ioie iaioiai
ae?aiao?o, i?ae a?eueoiai o «aeia/iiio» o??eieeo. sse iieacaei
iiaeaeueoa aeine?aeaeaiiy oea i?ecaaei aei iaiaeiaeiaiai c?inoaiiy
oaeaeeinoae ci?ie na?aaei?o ae?aiao??a i?ioie iaioiai (k1=-0,8300,002) ?
a?eueoiai i?ina?o?a (k2=-0,6260,001) (P <0,001). Oiio eiao?oe??io aneiao?e/iino? o naith /a?ao cieceany aei 1,3250,006 (P <0,001). *a?ac 7 ae?a i?ney noai?aii? ca aeaniei iaoiaeii iai?io?aeiino? aeia/iiai ?onea o an?o niaae ??cei ii?ooeeanue a?e?iaeeiai?ea (oene "i?ioiaeaeaiiy" c??n o 1,92 ?ace, oene "caeeoeiaee" o 2,6 ?ace, oene "i?oo?iaee" a 1,56 ?ace, iieaciee aeaa?oiao??? cieceany a 1,67 ?ace) (P <0,001). Oiio i?e ii?oiiao?e/iiio aeine?aeaeaii? ei??ic?eieo i?aia?ao?a aoei aeyaeaii ?icoe?aiiy aeia/ieo i?ioie c oa?aeoa?ieie aeey iueiai iniaeeainoyie ye o ethaeae c iaoo?aoe?eiei oieanoacii. Ii?ooaiiy i?inoi?iai? aoaeiae aeia/iiai aea?aaa ciaeoee nai? a?aeia?aaeaiiy o cia/aiiyo noa?aiiao?e/ieo eiinoaio. Ia?aiao?e k1(0,830 0,002) ? k2(0,6260,001) c?inee ia iaeiaeiai (P <0,001), oiio eiao?oe??io aneiao?e/iino? ciaioeany aei 1,3260,003 (P <0,001). Oaeei /eiii, i?e iecuee?e iai?io?aeiino? aeia/iiai ?onea i?inoi?iaa aoaeiaa aeia/iiai aea?aaa ethaeeie ? niaaee caa??aa? aeniiiaioe?eiee oa?aeoa?. I?ioa ne?ae caoaaaeeoe, ui i?e oeueiio niinoa??aaeiny a?eueoa a?aeoeeaiiy (aei 5 %) aenia?eiaioaeueii aei??yieo ae?aiao??a i?ioie ii/aoeiaeo ii?yaee?a a?ae oai?aoe/ii ciaeaeaieo, i?ae ca oiia ii?ie (aei 1%). Ii?ooaia a?e?iaeeiai?ea oa iioi?ia ooieoe?y aeaaiaaeoeyoeiaei? eeoee (aioo??oiueieeoeiaee oene c?inoaa c 0,490,02 eIa aei 0,780,02 eIa) (P <0,001) i?ecaiaeeee aei i?iieeiaiiy i?e?ioei?e oeoieiai-eeoeiaiai o?aeoo o aeia/i? oeyoe aeine?aeieo oaa?ei (iai?eeeaae, ai?no eeoeiai? iaee/ee noaiiaea 1,6 x 1040,3 x 104 EIA/ie) c ?icaeoeii aino?iai oieaia?iaaiaoeoo. I?e a?noieia?/iiio aeine?aeaeaii? oa?aeoa?ieie eiai i?iyaaie aoee aeaneaaiaoe?y ai?oae?th, eaeeioeeoa?ia ?io?eueo?aoe?y no?iee aeia/ieo i?ioie c oi?ioaaiiyi i?e?iaanoean?a. Ia a?noieia?/ieo c??cao ia/?iee aoei a?aei?/aii ?icoe?aiiy ii?oaeueieo o?aeo?a, aeeneiiieaenaoe?th, iae?ic, nioiao aeeno?io?th aaiaoioeeo?a. ?icaeoie aino?iai oieaia?iaaiaoeoo, ii?ooaiiy ii?oaeueiiai e?iaiia?ao (ii?oaeueiee oene c?inoaa c 1,08 0,02 eIa aei 1,470,04 eIa) (P<0,001) i?ecaiaeeee aei cieaeaiiy i?aiaioiiiai?iii? (ai?no caaaeueiiai a?e??oa?io e?ia? c?inoaa c 16,250,50 ieiieue/e aei 28,50 0,79ieiieue/e) (P<0,001) oa aeaceioieneeaoe?eii? ooieoe?e ia/?iee. sse iane?aeie aeieeaei c?inoaiiy ??aiy aiaeiaaiii? ?ioieneeaoe?? (??aaiue INI c??n a 1,88 ?ace, E?? - a 5,37 ?ace, NCA - a 1,45 ?ace, NA?? - a 1,34 ?ace) (P<0,001) oa c?ooaiiy eeneioii-eoaeiiai noaio aeia/? o eeneo noi?iio (pH i?oo?iai? aeia/? c 7,450,05 aei 6,100,05, i?ioieiai? - c 7,800,05 aei 6,350,05) (P<0,001). Ii?oiooieoe?iiaeueia oa?aeoa?enoeea aeia/ieo oeyo?a i?ney oi?ioaaiiy oieaaeioiaeoiaeaiaeueieo aianoiiic?a ca niiniaii TH?ao-Aeiia?aaeiaa *a?ac 21 aeiao o niaae i?ney oi?ioaaiiy oieaaeioiaeoiaeaiaeueieo aianoiiic?a ca niiniaii TH?ao-Aeiia?aaeiaa i?iaaaeai? iaiiiao?e/i? aeine?aeaeaiiy iieacaee cieaeaiiy oeneo "i?ioiaeaeaiiy" o 1,5 ?ace ? c?inoaiiy iieacieea aeaa?oiao??? o 2,4 ?ace a?aeiinii eiio?ieth (P<0,001). Oaeee noai a?e?iaeeiai?ee na?ae/eoue i?i a?aenooi?noue aiaoiii-ooieoe?iiaeueii? ?cieyoe?? aeia/iaea?aeii? nenoaie a?ae eeoe?aieea, yea aoea i?aeoaa?aeaeaia aeaeo?io?c?ieia?/iei aeine?aeaeaiiyi a?aoetheniino? oeeo aianoiiic?a. Aeyaeaiee aeoiaeaiia?e?a?iee ?aoethen i?ecaiaeea aei aeoeaiiai ?inoo i?e?ioei?e o aeia/? (iai?eeeaae, ai?no eeoeiai? iaee/ee noaiiaea 2,5x1040,2x104 EIA/ie). Anoaiiaeaia ciaioaiiy a?e?a?iiai oeneo (oene "caeeoeiaee" ia a?ae??ciyany a?ae eiio?ieth) noi?iaiaeaeoaaeinue auooaiiyi caiaeueiiai i?ioeano o aeia/ieo oeyoao (pH i?oo?iai? aeia/? 7,150,05, a i?ioieiai? - 7,250,05) (P<0,001) oa iie?auaiiyi ooieoe?i-iaeueiiai noaio aaiaoioeeo?a. Oae, ai?no caaaeueiiai a?e?-?oa?io e?ia? cieceany aei 21,450,71 ieiieue/e (P<0,001). I?ioa iacaaaeath/e ia ?yae iiceoeaieo iiiaio?a, caeeoeeanue a?ae/ooiith ?ioieneeaoe?y i?aai?cio oaa?ei (??aaiue INI o ieo ia?aaeuoaaa eiio?ieue a 1,26 ?ace, E??- o 2,87 ?ace, NCA a 1,25 ?ace (P<0,001), a NA?? a 1,12 ?ace (P<0,01)). A?noieia?/ia aeine?aeaeaiiy ciie aianoiiico aeyaeei ii?yae ?c aeeoociith eaeeioeeoa?iith ?io?eueo?aoe??th ?ic?inoaiiy niieo/ii? oeaieie. Aeano?oeoeai? i?ioeane o aeia/ieo oeyoao oa ia?aio?i? ia/?iee o ii??aiyii? c iaoo?aoe?eiei oieanoacii iaee a?eueo ae?aaeaiee caiaeueiee oa?aeoa?. I?ioa aoea iii?oiith oaiaeaioe?y aei a?aeiiaeaiiy a?o?oaeoii?ee ia/?ieiaeo o?aaaeoe. *a?ac 90 ae?a i?ney iia?aoe?? caa??aaeanue a?aenooi?noue aiaoiii-ooieoe?iiaeueii? ?cieyoe?? aeia/iaea?aeii? nenoaie a?ae eeoe?aieea c oa?aeoa?ieie aeey ia? ii?ooaiiyi a?e?iaeeiai?ee oa i?e?iaiith caa?oaeiai?noth aeia/?. I?e a?noieia?/iiio aeine?aeaeaii? ciie aianoiiico niinoa??aaeenue i?ioeane o?a?ioecaoe??, yaeua caiaeaiiy oa iaa?yeo. Aeeoocia e?ioiiae?ioaaaeueia ?io?eueo?aoe?y aeia/ieo i?ioie, ii?oaeueieo o?aeo?a oa ca?ienoa aeeno?io?y aaiaoioeeo?a cana?ae/eee iiaeaeueoa ?nioaaiiy oieaia?iaaiaoeoo o oaa?ei oe??? a?oie. O ii??aiyii? c iiia?aaei?i no?ieii niinoa?aaeaiiy, inoaii?e noi?iaiaeaeoaaany iacia/iei iia??oaiiyi i?aiaioiiiai?iii? oa aeaceioieneeaoe?eii? ooieoe?e ia/?iee. I?ioa eeneioii-eoaeiee noai aeia/? iaeaea ia ci?ieany. Ii?oiiao??y ei??ic?eieo i?aia?ao?a aeia/iiai aea?aaa oaa?ei, aaoaiiaaieo /a?ac 90 ae?a i?ney oi?ioaaiiy OAeA ca niiniaii TH?ao-Aeiia?aaeiaa, iieacaea ciaioaiiy ae?aiao??a aeia/ieo i?ioie. I?ioa a?aeoeeaiiy na?aaei?o ae?aiao??a ii/aoeiaeo ii?yaee?a aeia/ieo i?ioie, ?ic?aoiaaieo ca caeaaei?noth D=e-kz+b, a?ae aenia?eiaioaeueii aei??yieo aoei cia/iei (4-6%), ia a?aei?io a?ae a?aeoeeaiiy na?aaei?o ae?aiao??a i?ioie e?ioeaaeo ii?yaee?a (aei 2%). Io?eiai? aeai? ?acii ?c noa?aiiao?e/ieie eiinoaioaie (k1=-0,73010,0006, k2=-0,48240,0007, Ka= 1,5130,004 (P<0,001)) na?ae/aoue i?i iaaeinoaoi?noue a?aeoai?aiiy i?inoi?iai? aoaeiae aeia/iiai aea?aaa ? ia?oi/a?aiaa cieeiaiiy iaoieia?/ieo ci?i o i?ioieao e?ioeaaeo ii?yaee?a. Ii?oiooieoe?iiaeueia oa?aeoa?enoeea aeia/ieo oeyo?a i?ney oi?ioaaiiy oieaaeioiaeoiaeaiaeueieo aianoiiic?a ca niiniaii A?oaanueeiai *a?ac 21 aeiao i?ney oi?ioaaiiy OAeA ca niiniaii A?oaanueeiai i?iaaaeai? a?noieia?/i? aeine?aeaeaiiy aeyaeee aeaui a?eueoo caiaeueio ?aaeoe?th o cii? aianoiiico, aeia/ieo oeyoao oa ia/?ioe?, i?ae o a?aeiia?aeiee oa?i?i niinoa?aaeaiiy i?ney oi?ioaaiiy OAeA ca niiniaii TH?ao-Aeiia?aaeiaa. Iia'ycaii oea aoei c aeayeith cao?eieith aeia/ia?aeoieo ? a?aenooi?noth aiaoiii-ooieoe?iiaeueii? ?cieyoe?? aeia/iaea?aeii? nenoaie a?ae eeoe?aieea (oene "i?ioiaeaeaiiy" ? iieaciee aeaa?oiao??? o 1,2 ?ace ia?aaeuoaaee eiio?ieue) (P<0,05). Oiio o oaa?ei oe??? a?oie aoee aeaui a??o? iieaieee aiaeiaaiii? ?ioieneeaoe?? i?aai?cio, ai?noo a?e??oa?io o e?ia?, i?e?iaiiai oa eeneioii -eoaeiiai noaio aeia/?, i?ae o oaa?ei c OAeA ca TH?ao-Aeiia?aaeiaei. *a?ac 90 ae?a i?ney oi?ioaaiiy OAeA ca niiniaii A?oaanueeiai a?noieia?/ia aeine?aeaeaiiy aeyaeei ?icaeoie ?oaoeaaiai aianoiiiceoo. Oa?aeoa?ieie eiai i?iyaaie aoee cia/ia eaeeioeeoa?ia ?io?eueo?aoe?y oa ?ic?inoaiiy niieo/ii? oeaieie o cii? aianoiiico. Ii?ooaiiy a?e?iaeeiai?ee oa ii?oaeueiiai e?iaiia?ao aoei a?eueoei, i?ae o oaa?ei c 7-aeiaiaei iaoo?aoe?eiei oieanoacii (oene "i?ioiaeaeaiiy", oene "caeeoeiaee" c?inee a 1,08 ?ace, aaee/eia aeaa?oiao??? ciaioeeanue o 1,5 ?ace, a oene "ii?oaeueiee" c??n a 1,2 ?ace (P<0,001). E??i oiai, aoei a?aei?/aii iia??oaiiy i?e?iaiiai, eeneioii-eoaeiiai noaio aeia/? oa ooieoe?iiaeueieo iiaeeeainoae ia/?iee o a?eueo?e i???, i?ae i?e iiia?aaeiueiio oieanoac?. Oae, pH i?oo?iai? aeia/? noaiiaea 5,850,05, a i?ioieiai? -6,150,05 (P<0,001). Ai?no caaaeueiiai a?e??oa?io e?ia? noaiiaea 35,450,57 ieiieue/e (P<0,001), ??aaiue INI - 0,5500,005 oi.iae., E?? - 4,50,1, NCA - 60,40,2%, NA?? - 0,910,01 oi.iae. I?iaaaeaia a?noieia?/ia aeine?aeaeaiiy aeyaeei iciaee aino?iai oieaia?oo - iaa?ye oa ae?aaeaia eaeeioeeoa?ia ?io?eueo?aoe?y on?o oa??a no?iee i?ioie ?c oi?ioaaiiyi i?e?iaanoean?a. O ia?aio?i? ia/?iee i?ioeane aeeno?io?? aae aei iae?ia?ico aaiaoioeeo?a ia?aaaaeaee iaae yaeuaie caiaeaiiy oa ?aaaia?aoe??. Cia/ia ii?ooaiiy a?e?iaeeiai?ee oa ?icaeoie aino?iai oieaia?iaaiaoeoo ni?e/eieee cia/ia iioeiaeaeaiiy no?oeoo?ii-i?inoi?iai? aoaeiae aeia/iiai aea?aaa. Oae, ?icoe?aiiy caaaeueii? aeia/ii? i?ioiee ia 11% ia?aaeuoaaei ?? ?icoe?aiiy i?e iaoo?aoe?eiiio oieanoac? (P<0,001). Ii??aiyii c iai?io?aei?noth aeia/iiai ?onea ia?aiao?e k1(-0,85010,0002) ? k2(-0,65010,0009) c?inee ua a?eueo ia- iaeiaeiai (P<0,001). Oiio eiao?oe??io aneiao?e/iino? ua a?eueoa cieceany ? noaiiaea 1,3080,002 (P<0,001). Ii?oiooieoe?iiaeueia oa?aeoa?enoeea aeia/ieo oeyo?a i?ney oi?ioaaiiy oieaaeioiaeoiaeaiaeueieo aianoiiic?a ca aeaniei niiniaii Aeine?aeaeaiiy ooieoe?iiaeueieo aeanoeainoae OAeA aeanii? eiino?oeoe?? iieacaei, ui a?i aieiae?? aeinoaoi?ie eeaiaiieie aeanoeainoyie aeey caoeiaeaeaiiy aeieeiaiith aeoiaeaiia?e?a?iiai ?aoetheno i?e aeinoaoi?e iaoai?/i?e i?oeiino? oa?a (/a?ac 90 ae?a oae aeo?eioaaee oene 34010 ii ?o.no.). Oey eiai a?aei?ii?noue a?ae iiia?aaei?o niinia?a iiynith? cia/ii iaioo caiaeueio ?aaeoe?th o cii? aianoiiico, aeia/iaea?aeieo oeyoao, ia/?ioe? ye o aeecueeiio, oae ? o a?aeaeaeaiiio ia??iae? niinoa?aaeaiiy. A?eueoa oiai, i?e?ia?ieia?/ia aeine?aeaeaiiy aeia/? /a?ac 90 ae?a i?ney iia?aoe?? aeyaeei i?i?iaeueio i?e?iaio caa?oaeiai?noue (1,2x1020,1x102 EIA/ie), a eeneioii-eoaeiee noai aeia/? a?aeiia?aeaa eiio?ieth. Cieaeaiiy ??aiy aiaeiaaiii? ?ioie-neeaoe?? a?aeaoaaeinue oaeaeoa, i?ae o oaa?ei o?aouei? oa /aoaa?oi? a?oi, a o a?aeaeaeaiiio ia??iae? eaai?aoi?i? iieacieee aiaeiaaiii? ?ioieneeaoe?? ia a?ae??ciyeenue a?ae eiio?ieth. Eeaiaii? aeanoeaino? aianoiiico noai?thaaee iaiao?aei? oiiae aeey a?eueiiai aeia/ia?aeoieo, cieeiaiiy aioo??oiueieeoeiai? a?ia?oaic??. A?aeiiaeaiiy ii?ooaii? a?e?iaeeiai?ee iiceoeaii aieeioei ia no?oeoo?ii-i?inoi?iao aoaeiao aeia/iiai ?onea oa ii?oieia?/iee noai ia/?iee. Oae, o a?aeaeaeaiiio ia??iae? o iicaia/?ieiaeo aeia/ieo oeyoao ii?yae ?c a?aenooi?noth i?ioean?a o?a?ioecaoe??, iaa?yeo oa caiaeaiiy aoei a?aei?/aii iiyao iiaeo i'ycaaeo aieieii. Ii?oieia?/iee noai ia/?iee ia a?ae??ciyany a?ae eiio?ieth. Aiae?c ei??ic?eieo i?aia?ao?a iieacaa cia/ia ciaioaiiy ae?aiao??a i?ioie on?o ii?yaee?a: i?ioiee 4-7 ii?yaee?a iaeaea ia a?ae??ciyeenue a?ae eiio?ieth. Ia iaoo aeoieo, caeeoie ?icoe?aiiy i?ioie 1-3 ii?yaeeo o i?neyiia?aoe?eiiio ia??iae? ii'ycaii c oei, ui aiie caciaee a?eueoeo iaoieia?/ieo ci?i i?e oieanoac?. Noa?aiiao?e/i? eiinoaioe i?inoi?iai? aoaeiae aeia/iiai aea?aaa oaeiae aoee e?aueie, i?ae o oaa?ei o?aouei? oa /aoaa?oi? a?oi (k1=-0,68000,0005; k2=-0,41810,0009; Ka= 1,6300,003) (P<0,001). AENIIAEE 1. AEia/iiio aea?aao aeanoea? aneiao?e/i?noue oa aeniiiaioe?eiee oa?aeoa? i?inoi?iai? aoaeiae. Ca oiia ii?ie noa?aiiao?e/i? ia?aiao?e - oaeaeeino? ci?ie na?aaei?o ae?aiao??a a?eie iaioiai (k1=-0,6350,004) ? a?eueoiai (k2=-0,3640,004) i?ina?o?a oa eiao?oe??io aneiao?e/iino? (Ka=1,7450,028) ? aaee/eie noae?. 2. A?e?a?ia a?ia?oaic?y i?e aenia?eiaioaeuei?e /anoeia?e iai?io?aeiino? aeia/ieo oeyo?a i?ecaiaeeoue aei ?icaeoeo aino?iai oieaia?iaaiaoeoo (iae?ic, aeaneaaiaoe?y ai?oae?th ?c caiaeueiith ?io?eueo?aoe??th no?iee aeia/ieo i?ioie, nioiaa aeeno?io?y aaiaoioeeo?a, i?e?iaia caa?oaeiai?noue aeia/?) oa no?oeoo?ii-i?inoi?iai? ia?aaoaeiae aeia/iiai aea?aaa. Oaeaeeino? ci?ie na?aaei?o ae?aiao??a i?ioie iaioiai oa a?eueoiai i?ina?o?a c?inoathoue iaiaeiaeiai (-0,8300,002 ? -0,6260,001), a?aeiia?aeii ciaioo?oueny eiao?oe??io aneiao?e/iino? (1,3260,003). 3. O??o?a?/ia ei?aeoe?y iaoo?aoe?eiiai oieanoaco oeyoii oi?ioaaiiy oieaaeioiaeoiaeaiaeueiiai aianoiiico ca niiniaii TH?ao-Aeiia?aaeiaa, /a?ac iaaeinoaoi?noue eiai eeaiaieo aeanoeainoae, ia ni?ey? iiaiiio cai?ioiueiio ?icaeoeo oieaia?iaaiaoeoo (aeeoocia e?ioiiae?ioaaaeueia ?io?eueo?aoe?y aeia/ieo i?ioie, ii?oaeueieo o?aeo?a, ca?ienoa aeeno?io?y aaiaoioeeo?a). Oiio iiaiiai a?aeiiaeaiiy i?inoi?iai? aoaeiae aeia/iiai aea?aaa i?e aeaiiio niinia? e?eoaaiiy ia a?aeaoaaeinue (k 1= -0,7301  0,0006; k2= -0,4824 0,0007; Ka= 1,513  0,004). 4. O??o?a?/ia ei?aeoe?y iaoo?aoe?eiiai oieanoaco oeyoii oi?ioaaiiy oieaaeioiaeoiaeaiaeueiiai aianoiiico ca niiniaii A?oaanueeiai, aiane?aeie ?oaoeaaiai aianoiiiceoo (caiaeueia ?io?eueo?aoe?y oa ?ic?inoaiiy niieo/ii? oeaieie o cii? aianoiiico), i?ecaiaeeoue aei iiaeaeueoiai ?icaeoeo oieaia?iaaiaoeoo (aeeoocia caiaeueia ?io?eueo?aoe?y no?iie aeia/ieo i?ioie ?c oi?ioaaiiyi i?e?iaanoean?a, oieaeueiee eie?eaaoe?eiee iae?ic ia/?iee) oa iineeaiiy ii?ooaiue o i?inoi?ia?e aoaeia? aeia/iiai aea?aaa (k1=-0,8501 0,0002; k2=-0,65010,0009; Ka=1,3080,002). 5. Onoiaiiy ia?aoeiaee aeey aeia/ia?aeoieo oeyoii oi?ioaaiiy oieaaeioiaeoiaeaiaeueiiai aianoiiico ca aeaniith iaoiaeeeith ni?ey? a?aeiiaeaiith ii?oiooieoe?iiaeueiiai noaio ia/?iee oa aeia/ieo oeyo?a. Oea i?iyaeyeinue o cieeiaii? a?e??oa?iai??, i?e?iaii? caa?oaeiaiino? aeia/?, iciae aino?iai oieaia?iaaiaoeoo oa a?aeiiaeaii? i?inoi?iai? aoaeiae aeia/iiai aea?aaa (k1=-0,68000,0005; k2=-0,4181 0,0009; Ka=1,6300,003). 6. O??o?a?/ia e?eoaaiiy iaoo?aoe?eiiai oieanoaco oeyoii oi?ioaaiiy oieaaeioiaeoiaeaiaeueiiai aianoiiico ca aeaniith iaoiaeeeith, caaaeyee eiai eeaiaiei aeanoeainoyi, a?aeiiaeth? a?e?iaeeiai?eo aei eiio?ieueieo oeeo?. Ca aeaieie eaai?aoi?ieo iieaciee?a ??aaiue aiaeiaaiii? ?ioieneeaoe??, eeneioii-eoaeiee noai aeia/? a?aeiia?aeaee eiio?ieth. NIENIE IAOEIAEO I?AOeUe, IIOAE?EIAAIEO II OAI? AeENA?OAOe?? 1. Ieueoiiye A.A., Einothe A.ss., AEo/aiei N.I., Eiaaeue/oe I.I. Noa?aiiao?e/aneea eiinoaiou aeae/iiai aea?aaa /aeiaaea a ii?ia e i?e aiaia/aii/iii oieanoaca //A?niee ii?oieia??.- 1997.- O.3.- N1.- C.42-43. 2. Ieueoiiye I.I., Aiaa/oe N.A., I?aoi?ae A.?., Einothe A.ss., AEo/aiei N.I., sse?iaiei I.A. Ii?oiaaiac neiae?iio aiaeiaaiii? ?ioieneeaoe?? i?e oieanoac? (aenia?eiaioaeueia aeine?aeaeaiiy) //A?niee ii?oieia??.- 1997.- O.3.- N2.- C.120-122. 3. I?aoi?ae A.?., Ieueoiiye I.I., Caai?ai?iaea I.E.. Aca?iica'ycie ii?oiooieoe?iiaeueiiai noaio oeoieo, aeaaiaaeoeyoeiaei? eeoee oa nooeoo?ii-i?inoi?iai? aoaeiae aeia/iiai aea?aaa //A?niee ii?oieia??.- 1998.- O.4.- N1.- C.118-119. 4. Ieueoiiye I.I., Einothe A.ss., AEo/aiei N.I., Aiaa/oe N.A. Ii?oiooieoe?iiaeueia oa?aeoa?enoeea aeia/ieo oeyo?a a oiiaao aenia?eiaioaeueiiai oieanoaco oa eiai o??o?a?/ii? ei??aeoe?? //Iaoa??aee 5 ?anioae?eainueei? o/aiai-iaoiaee/ii? eiioa?aioe?? caa?aeoth/eo eaoaae?aie caaaeueii? o??o?a?? iaaeaoc?a Oe?a?ie, Oa?iii?eue, 1996.- N.51-52. 5. Ieueoiiye I.I., Einothe A.ss., AEo/aiei N.I. Ii?oieia?/i? aeine?aeaeaiiy a?e?iaeeaanoeaieo aianoiiic?a //Ca??iee iaoeiaeo ?ia?o i?aeia?iaeii? eiioa?aioe?? "Aeooaeuei? ieoaiiy ii?oieia??", Oa?iii?eue, 1996.- O.2.- N.488-489. 6. Ieueoiiye I.I., O?i?/ N.Ae., Einothe A.ss., AEo/aiei N.I., Aoaianthe I.?. Ii?oiooieoe?iiaeuei? aeine?aeaeaiiy o??o?a?/ii? ei??aeoe?? iicaia/?ieiaiai oieanoaco //Iaoa??aee i?aeia?iaeii? eiioa?aioe?? "Iia? oaoiieia?? a o??o?a??", Oaeai?iae, 1997.- N.58. 7. Khimich S.D., Konoplitsky V.S., Olkchomyak A.A., Kostyuk G.Y. Syndrome of endogenous intoxication with cholestasis //Austrian - Hungarian - Slovacian Falc-Symposium "Cholestatic liver diseases", Bratislava , 1996.- P.4. 8. Khimich S.D., Olkchomyak A.A., Konoplitsky V.S., Dovgan I.P. Correlation of the endogenous intoxication Syndrome (EI) with morphological changes in case of intra and extrahepatic cholestasis //XIV International Bile Acid Meeting "Bile Acids in Hepatobiliary Diseases", Freiburg, 1996.- P.147. AIIOAOe?ss Ieueoiiye I.I. Ii?oiooieoe?iiaeueia oa iaoaiaoe/ia ioe?iea noaio aeia/iiai ?onea a caeaaeiino? a?ae aeaeo a?e?iaeeaanoeaiiai niieo/aiiy (aenia?eiaioaeueia aeine?aeaeaiiy).- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.03.01 - ii?iaeueia aiaoii?y.- Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i.?.Ai?aa/aanueeiai, Oa?iii?eue, 1998. Aeena?oaoe?y i?enay/aia ieoaiith ii?oiooieoe?iiaeueiiai noaio oa i?inoi?iai? aoaeiae aeia/iaea?aeieo oeyo?a. O aeena?oaoe?? ?ic?iaey?oueny iiaa iai?aaeaiiy ae?aaiinoeee caoai?thaaiue ia/?iee ? aeia/iaea?aeieo oeyo?a, yea a?oioo?oueny ia noa?aiiao?e/iiio aiae?c? aeaieo oieaia?ia?ai oa ei??ic?eieo i?aia?ao?a aeia/iiai aea?aaa. Anoaiiaeaii, ui ii?ooaiiy a?e?iaeeiai?ee i?e iaoo?aoe?eiiio oieanoac? i?ecaiaeeoue aei iaoieia?/ieo ci?i o i?inoi?iai - noa?aiiao?e/i?e aoaeia? aeia/iiai aea?aaa. Cai?iiiiiaaiee a?aoetheniee a?e?iaeeaanoeaiee aianoiiic aeaniinii? eiino?oeoe??, ia a?aei?io a?ae aianoiiic?a TH?ao-Aeiia?aaeiaa oa A?oaanueeiai, iiia?aaeaeoth/e ?icaeoie ?aoethen-oieaia?oo, ni?ey? a?aeoai?aiith i?inoi?iai-noa?aiiao?e/ii? aoaeiae aeia/ieo oeyo?a. Eeth/ia? neiaa: aeia/i? i?ioiee, ii?oieia?y, iaoo?aoe?eiee oieanoac, a?e?iaeeaanoeaiee aianoiiic. A I I I O A Oe E ss Ieueoiiye A.A. Ii?oiooieoeeiiaeueiay e iaoaiaoe/aneay ioeaiea ninoiyiey aeae/iiai ?onea a caaeneiinoe io aeaea aeeeiaeeaanoeaiiai niaaeeiaiey (yenia?eiaioaeueiia enneaaeiaaiea).?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe - 14.03.01 - ii?iaeueiay aiaoiiey. Oa?iiiieueneay ainoaea?noaaiiay iaaeeoeeineay aeaaeaiey ei.E.Ai?aa/aaneiai, Oa?iiiieue, 1998. Aeena?oaoeey iinayuaia aii?ino ii?oiooieoeeiiaeueiiai ninoiyiey e i?ino?ainoaaiiiai no?iaiey aeae/aauaiaeyueo iooae. A aeena?oaoeee ?ac?aaaouaaaony iiaia iai?aaeaiea aeeaaiinoeee caaieaaaiee ia/aie e aeae/aauaiaeyueo iooae ia iniiaaiee noa?iiao?e/aneiai aiaeeca aeaiuo oieaiaeia?ai e ei??iceiiuo i?aia?aoia. Onoaiiaeaii, /oi iaeiei ec i?eciaeia i?ino?ainoaaiiiai no?iaiey aeae/iuo iooae yaeyaony anneiao?e/iinoue. Iineaaeiyy caeeth/aaony a iaiaeeiaeiaii aeeaiao?a i?ioieia iinea i/a?aaeiiai ?acaaoeaiey. Aoi?ui aaaeiui i?eciaeii i?ino?ainoaaiiiai no?iaiey aeae/iuo iooae yaeyaony yeniiiaioeeaeueiay caaeneiinoue oiaiueoaiey aeeaiao?ia i?ioieia io ai?io ia/aie e ia?aoe?ee i?aaia. Ioia?aaeaieai yoeo i?eciaeia yaeythony noa?aiiao?e/aneea eiinoaiou - eiyoeoeeaio anneiao?e/iinoe, nei?inoe oauaaiey aeeaiao?ia i?ioie aieueoeo e iaiueoeo i?inaaoia. A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee onoaiiaeaii, /oi ia?ooaiea aeeeiaeeiaieee i?e iaoo?aoeeiiii oieanoaca i?eaiaeeo ia oieueei e iee?iaiiio caa?yciaieth aeae/e n eciaiaieai aa eeneioii-iniiaiiai ninoiyiey, aicieeiiaaieth oieaiaeiaaiaoeoa n oaaee/aieai o?iaiy aiaeiaaiiie eioieneeaoeee, ii e e ia?ooaieth i?ino?ainoaiiiai no?iaiey aeae/iuo iooae. Oae eae, auei ioia/aiii i?aeiouanoaaiiia oaaee/aiea aeeaiao?ia i?ioieia aieueoeo i?inaaoia, iaaeaee iaiueoeo e ia/aeueiuo ii?yaeeia, iaaeaee eiia/iuo, oi nei?inoe oauaaiey aeeaiao?ia i?ioieia iaiueoeo e aieueoeo i?inaaoia au?inee iaiaeeiaeiai e eiaoeoeeaio anneiao?e/iinoe nieceeny. I?iaaaeaiiia n?aaieoaeueiia eco/aiea aiciiaeiinoae oieaaeioiaeoiaeaiaeueiuo aianoiiicia ainnoaiaaeeaaoue no?oeoo?ii-i?ino?ainoaaiiia no?iaiea aeae/aauaiaeyuae nenoaiu iieacaei neaaeothuaa. Oi?ie?iaaiea aianoiiicia ca Aeoaaneei nii?iaiaeaeaaony aua aieueoei oooaeoaieai ii?oieiae/aneiai e i?ino?ainoaaiiiai no?iaiey aeae/iuo iooae ec-ca ?oaoeiaiai aianoiiiceoa. Oi?ie?iaaiea aianoiiicia ca TH?ao-Aeiia?aaeiaui niinianoaoao ooaeaio ainoaiiaeaieth no?iaiey aeae/iuo iooae, iaaeaee oi?ie?iaaiea aianoiiicia nianoaaiiie eiino?oeoeee ec-ca ieioeo eeaiaiiuo naienoa. I?aaeeiaeaiiue a?aoetheniue aeeeiaeeaanoeaiue aianoiiic nianoaaiiie eiino?oeoeee, a ioee/ee io aianoiiicia TH?ao-Aeiia?aaeiaa e Aeoaaneiai, i?aaeoi?aaeaeay ?acaeoea ?aoethen-oieaiaeoa, niinianoaoao ainnicaeaieth i?ino?ainoaaiiiai no?iaiey aeae/iuo iooae, ii?iaeueiie aeeeiaeeiaieee, iee?iaiiai e eeneioii-iniiaiiai noaoona aeae/e, nieaeaieth o?iaiy yiaeiaaiiie eioieneeaoeee. Eeth/aaua neiaa: aeae/iua i?ioiee, ii?oieiaey, iaoo?aoeeiiue oieanoac, aeeeiaeeaanoeaiue aianoiiic. SUMMARY Olkchomyak A.A. The morphofunctional and mathematical appreciation of the condition of bile channel, depending on the type of biliodigestic complexes (Experimental research). - Manuscript. Thesis for a candidat's degree by speciality 14.03.01 - normal anatomy. The Ternopil' medical state academy named after I.Gorbachevsky, Ternopil',1998. The dissertation is devoted to the question of morphofunctional condition and spacial structure of bile ducts. In dissertation elaborated new directions in diagnostics of diseases of liver and bile ducts, on the basis of stereometric researches of given cholangiogramm and corrosive preperations. Determined that disturbance of biodynamics in obstruction cholestasis, results to pathological changes in spacial- stereometric structure of biliary tree. Suggested arefluxional biodigestive anastamosis of proper construction, in differ to that of anastamosis of Urashz - Vinogradov's and Vetabsky's, which prevents the development of cholangitis reflux, promotes in normalisation of spacial structure of bile tracts. Key words: bile ducts, morphology, obstruction cholestasis, biliodigestive anastamosis.

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