Ефективність лаферона і стрептонітола в комплексному лікуванні бешихи у моряків: Автореф. дис… канд. мед. наук / В.Я. Купрата, Держ. п-во ‘Укр. НДІ

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ieAea?aeaaia i?aei?e?inoai
“Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ii?nueei? iaaeeoeeie”

Eoi?aoa A??a ss?ineaa?aia.

OAeE 616.98.862.1/-085.37

Aoaeoeai?noue eaoa?iia ? no?aioii?oiea a eiiieaeniiio e?eoaaii? aaoeoe o
ii?ye?a.

14.01.34 — aa?aoe?eia, eini?/ia oa ii?nueea iaaeeoeeia

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Iaeana — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia ia aac? aea?aeaaiiai i?aei?e?inoaa “Oe?a?inueeee
iaoeiai-aeine?aeiee ?inoeooo ii?nueei? iaaeeoeeie”

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, aeioeaio Caii?iae/aiei
Ai?en Na?a?eiae/ , caa?aeoaa/ o??o?a?/iith ee?i?eith aea?aeaaiiai
i?aei?e?inoaa “Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ii?nueei?
iaaeeoeeie”

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? A?oai?e Aieiaeeie?
Aieiaeeie?iae/, caa?aeoaa/ eaoaae?e oieoaeueii? o??o?a?? Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo;aeieoi? iaaee/ieo iaoe Aeaaoy?aiei
Oaoyia Aieiaeeie??aia, i?ia?aeiee iaoeiaee ni?a?ia?oiee eaai?aoi??? oa
iaoiii?oieia?? oeaiei ?inoeooo i/ieo oai?ia ? oeaiaai? oa?ai??
?i.A.I.O?eaoiaa AII Oe?a?ie.

I?ia?aeia onoaiiaa: Oa?e?anueea aeaaeai?y i?neyaeeieiiii? ina?oe IIC
Oe?a?ie.

Caoeno a?aeaoaeaoueny “11” aeiaoiy 1999 ?. i 13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.617.01 AeI “Oe?a?inueeee
iaoeiai-aeine?aeiee ?inoeooo ii?nueei? iaaeeoeeie” ca aae?anith: 270049,
i. Iaeana, aoe. Noaeiiaoae?aia, 1.

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? AeI “Oe?a?inueeee
iaoeiai-aeine?aeiee ?inoeooo ii?nueei? iaaeeoeeie”.

Aaoi?aoa?ao ?ic?neaiee “16” na?iiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee e.iaae.i., aeioeaio
I.A.Ieaoue?aa

Aeooaeueiinoue oaie. Caoai?thaaiiy ia aaoeoo caeia? iaeia c
iaeaaaeeeaioeo iinoeue a iaoieiai? ethaeeie i aiaeiineoueny aei /enea
nioeiaeueii-cia/oueo iaaee/ieo i?iaeai o ca’yceo ic cia/iith /anoioith,
oyaeinoth oa aaaeeeie ianeiaeeaie caoai?thaaiiy (A. E. *a?eania, 1993,
A. I. O?ieia, 1994 oa ii.).

?iaaiue caoai?thaaiiy aaoeoith ca aeaieie Ananaioiuei? i?aaiicaoei?
ioi?iie caei?ia’y ca inoaiii aeanyoeeiooy cia/ii c?in i neeaaea? 20-22
/ieiaiea ia 10000 ianaeaiiy, ia? /ioei ae?aaeaio oaiaeaioeith aei
caieueoaiiy o?iii/ieo i ?aoeeaeeaoth/eo oi?i (Atheaoaiue AE?IC, 1987, N
6).

Iacaaaeath/e ia iaai? oniioe iaaeeeaiaioiciiai i oi?o?ai/iiai eieoaaiiy
aaoeoe, i?iaeaia ?ic?iaee aoaeoeaieo iaoiaeia eieoaaiiy aeaiiai
caoai?thaaiiy ? aeaeaeith aiae ?? ae?ioaiiy. Oea iaoiiaeaii ye
neeaaeiinoth iaoiaaiaoe/ieo iaoaiiciia ?icaeoeo aaoeoe, iaaeinoaoiueith
aoaeoeaiinoth inioth/eo iaoiaeia eieoaaiiy, oae i no?iieei c?inoii
caoai?thaaiiy ia aaoeoo a oeeaieiciaaieo e?a?iao, a oiio /enei i a
Oe?a?ii, ui, c o?aooaaiiyi cia/ii? ao?aoe i?aoeacaeaoiinoi i aeniei?
iiaaeiaeecaoei?, iaaea? i?iaeaii eieoaaiiy oai?eo ia aaoeoo /ioei
nioeiaeueiee oa?aeoa?.

Ca aeaieie A. N. Caii?iae/aiei i ni?aaao., 1998 caoai?thaaiiy ia aaoeoo
na?aae ii?yeia o 2 ?ace aeua iaaaaeaiiai iieacieea, ui aecia/a?oueny
niaoeeoi/ieie oiiaaie ?iaioe, aieeaii ia i?aaiici ii?yea iaaaoeaieo
iaoa?iieiai/ieo, eeiiaoe/ieo, a oaeiae oice/ieo i oiii/ieo oaeoi?ia
ae?iaie/iai na?aaeiaeua — aaaeeeo iiiia, ia?ia ?ic/eiia, ?icieo aeaeia
oaieiaiai aei?iiiithaaiiy.

Aiaeii/aii oaeoi?e yaeythoueny no?aniaeie, ui ii?yae ic c?inoii
iie?io?aaiaoecio na?aae ii?yeia, ic iiieaeaiiyi iioiieiai/ii?
?aaeoeaiinoi i?aaiicio a ?aeni ni?ey? aeieeiaiith aaoeoe o ii?yeia i ?
i?e/eiith ianoieueee /anoiai caoai?thaaiiy aaoeoith (A. I. Eiaaiei, A.
N. Caii?iae/aiei, 1995). ?acii c oei, aiiaeaiiieiaiy aaoeoe, iiaeeeaee
aieea i?ioaniiiaeueii? aeiyeueiinoi ii?yea i noa?e aeeooy o Naioiaiio
ieaaii ia aoiiiaoiaaiaoe/ii iiiaioe caoai?thaaiiy caeeoathoueny
iaaeinoaoiuei aea/aii.

Cia/iee aieea ia oiae ?aia?aoeaieo i?ioeania ia? iie?iaia ianiyiinoue i
oa?aeoa? iie?ioei?e aaoeoe. Iie?ioei?a i?eaii/o? caoenio ?aaeoeith,
aoii?aeueii i eeioeiii oaeoi?e a?iaeaeaiiai iioiioaoo, i?ecaiaeeoue aei
aiieii-caiaethaaeueieo oneeaaeiaiue, oiiaieueith? i?ioean oi?ioaaiiy
a?aioeyoeieii? oeaieie.

O i?aoeyo aiaeiieo o/aieo aeiaaaeaii ?icaeoie aoi?eiii? iioiieiai/ii?
iaaeinoaoiinoi ia oiii aiia?naineaieicaoei? aei aea?aaio aaiieioe/iiai
no?aioieiea (A. E. *a?eania, 1977, 1986; I. A. Ia?anaaeii, 1984, 1989;
I. A. Aaea, 1987, 1990; A. I. O?ieia, 1985; I. A. Aaneaeia, 1987; A. O.
?acaieiaa, 1988 oa ii.).

Iaeiae, a aoiiiaoiaaiaci aaoeoe iiaeooue a?aoe o/anoue e iioi
iie?ii?aaiicie, yei ni?eythoue caaino?aiith ia?aaiao caoai?thaaiiy (A.
A. I?ineo?ia, 1970; I.A. THnoiia, ?. I. ssoa?ia, 1988; A. A. Iioaiai,
1987). Oeae oaeo iaaeinoaoiuei a?aoiao?oueny i?e i?iaaaeaiii iinoeaaiai
i caaaeueiiai eieoaaiiy aaoeoe i iiynith? eiai iaaeinoaoith
aoaeoeaiinoue ia?aci.

No/aniee aoai iaoeiaeo aeineiaeaeaiue aiaecia/eany aaeeeeie oniioaie a
iaeanoi aea/aiiy iioiiiiaeoeyoi?ia, a aeaiiio ?aci iioa?oa?iia (IOI),
iaoaiicio eiai ooai?aiiy i aei?, iniaeeainoi eiai aieeao ia ?icii
ooieoei? eeioei i iiaeo?eieo aiiainoaca i?aaiicio (A. Ae. Nieiaeia, O.
A. Aaeoaii?ia, 1984).

O ca’yceo c oiiaa?naeueii oe?ieei niaeo?ii aeoeaiinoi (aioeai?oniei,
aioei?ieioa?aoeaiei i iioiiiiaeoethth/ei IOI) ana aieueoo oaaao
i?eaa?oa? niaoeiaeino?a ?iciiai i?ioieth. Aei oaia?ioiueiai /ano a ?yaei
?iaio inaioeaii ieoaiiy oa?aii? aaoeoe a iniiaiiio c aeei?enoaiiyi ?o ye
iioiiiiaeoeyoi?ia: iaoieo?aoeeea, aeaea?ina, oaeoiaiia i nieaiiia (I. A.
Aaea, 1987; I. I. Aaneaeia, 1987; A. O. ?acaieiaa, 1988).

Noai?aiiy oe?a?inueeeie a/aieie iiae ea?iaieoeoaii A. A. Eo?aethi
?aeiiaiiaioiiai aeueoa 2-a iioa?oa?iia – Eaoa?iia aeaei iiaeeeainoue
i?iaanoe iaoeiai aeineiaeaeaiiy aoaeoeaiinoi aeaiiai i?aia?aoa i?e
aaoeni.

Aeeth/aiiy a eiiieaenio oa?aiith aaoeoe eaoa?iia cia/ii iie?auo?
eeiiiei-iioiieiai/ii iieacieee, i?ecaiaeeoue aei cieaeaiiy /anoioe
aiieii-caiaeueieo oneeaaeiaiue oa ianeiaeeiaeo yaeu (eiioinoaca,
iiaeo?aoeaiee iaa?ye), a oaeiae ?aoeeaeeaia aaoeoe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoeiy aeeiiaia aiaeiiaiaeii aei ieaio iaoeiai-aeineiaeieo ?iaio
AeI IAe? ii?nueei? iaaeeoeeie i ? o?aaiaioii aeineiaeaeaiue ieaiiai?
iaoeiai-aeineiaeii? oaie ca ? aea?aeaaii? ?a?no?aoei? 01.86.000.6102.

Iaoith ?iaioe aoei noai?aiiy aenieiaoaeoeaiiai eiiieaeniiai eieoaaiiy
oai?eo aino?eie i o?iii/ieie oi?iaie aaoeoe ia iniiai ia’?aeiaiiy
iioiiei?aaoth/i? oa?aii? eaoa?iiii, aioeaaeoa?iaeueii? oa?aii? i
iinoeaaiai canoinoaaiiy no?aioiiioieo, aeoiaey/e ic aeineiaeaeaiiy ?iei
iioiii? nenoaie a iaoaiiciao aeieeiaiiy i ?icaeoeo aaoeoe.

Iniiaii caaaeaiiy aeineiaeaeaiiy aoee oaeeie:

Aea/eoe ?iaaiue caoai?thaaiiy ia aaoeoo na?aae ia?niiaeo iniiaieo
ii?nueeeo i?ioanie, iniaeeainoi eeiii/iiai ia?aaiao oa
ao?iiaoiaaiaoe/ieo oaeoi??a, ye? ni?eythoue ?aoeaaeeaoaaiith aeaiiai
caoai?thaaiiy o ii?yeia.

I?iaanoe aeineiaeaeaiiy ia /ooo?ainoue iioiiioeeoia aei eaoa?iio ia
iniiai aeei?enoaiiy iioiieiai/ieo iaoiaeia.

Aea/eoe noai aeayeeo oaeoi?ia aoii?aeueiiai i eeioeiiiai iioiioaoo a
oiiaao o?aaeeoeieii? oa?aii? i oa?aii? c aeeth/aiiyi ?ioiiiiaeoeyoi?a –
eaoa?iia.

Aea/eoe aaciina?aaeii ?acoeueoaoe eiiieaeniiai eieoaaiiy oai?eo
aaoeoith, aeeth/ath/e iioiiiei?aeyoeith oa iinoeaaa canoinoaaiiy iaci
“No?aioiiioie”.

Aea/eoe iniaeeainoi o?oaeiai? i i?ioanieii? ?aaaieioaoei? ii?yeia
iiney eiiieaeniiai eieoaaiiy aaoeoe eaoa?iiii i iinoeaaiai canoinoaaiiy
no?aioiiioiea.

Iaoeiaa iiaecia. Aia?oa a iaaee/iie i?aeoeoei aea/aii ?iaaiue
caoai?thaaiiy aaoeoith o ii?yeia i ?iciiaeie oeueiai caoai?thaaiiy
na?aae inia iniiaieo ii?nueeeo i?ioanie.

Aia?oa i?e eieoaaiii aaoeoe aoei canoiniaaii aio/eciyiee iioiiee
i?aia?ao “Eaoa?ii”.

Aia?oa aecia/aii aeico eaoa?iia i?e ?icieo oi?iao caoai?thaaiiy
aaoeoith o ii?ye?a.

Aia?oa aeyaeaii, ui eiiieaenia canoinoaaiiy “Eaoa?iia” i iaci
“No?aioiiioie” caeienith? ae?aaeaiee eieoaaeueiee aoaeo aiaeiinii
ii?ooaiue iioiieiai/ii? ?aaeoeaiinoi o oai?eo aaoeoith.

Aia?oa anoaiiaeaii iiceoeaiee eeiii/iee aoaeo canoinoaaiiy iaci ia
aiae?ioieueiie iniiai “No?aioiiioie” a eiiieaeniiio eieoaaiii aaoeoe o
ii?yeia i?ae /an ?o ia?aaoaaiiy o a?aee?eoiio ii??.

Aia?oa i?e eaoa?iiioa?aii? i canoinoaaii? iaci “No?aioiiioie” aecia/aii
iaeaieueo ni?eyoeeao (??-o) oaco ?aiaaiai i?ioeano o oai?eo aaoeoith.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoaoia. Iiai aeaii, iaea?aeaii a
?iaioi, iathoue oai?aoe/ia i i?aeoe/ia cia/aiiy. Noai?aii ia?aaeoiiae
aeey iiaeaeueoiai aeineiaeaeaiiy i aecia/aiiy iniaeeainoae aaoeoe i
iiooe iiaeo caniaia ?? eieoaaiiy o ii?ye?a.

Aeoiaey/e c io?eiaieo aeaieo, oai?aoe/ii iaa?oioiaaii canoinoaaiiy
iioiiiei?aaoth/i? oa?aii? i?aia?aoa “Eaoa?ii”, a oaeiae iinoeaaiai
eieoaaiiy iaci “No?aioiiioie” i aeyaeaii aenieo aoaeoeaiinoue
cai?iiiiiaaii? oa?aii? o oai?eo ia aaoeoo.

Aecia/aii iioeiaeueii aeice canoinoaaiiy eaoa?iia o oai?eo aaoeoith.

?ic?iaeaii niinia eieoaaiiy aaoeoe c aeei?enoaiiyi iaci “No?aioiiioie”.

Ai?iaaaeaeaii i ioioeieii ca?a?no?iaaii cayaeo ia iaoaio N 96052167
“Niinia eieoaaiiy aaoeoe”.

Iaaeaii ?aeiiaiaeaoei? ii aeei?enoaiith eaoa?iia oa no?aioiiioiea i?e
?icieo oi?iao aaoeoe o ii?ye?a.

?acoeueoaoe ?iaioe ai?iaaaeaeaii o aeiyeueiinoue oi?o?ai/ieo
aiaeaeieaiue Icia?euenueei? aanaeiiai?, Ieei/ianueei?, Ieeiea?anueei?,
?aiienueei? oa Eieienueei? ii?oiaeo eiea?aiue oa noaeiaeo aiaoeaoi??e.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioea iniaenoi i?iaaea
iaoaioii-iioi?iaoeieiee iiooe, aecia/eea iaoiaee/ii iiaeoiaee, aeeiiaea
eeiii/ii aeineiaeaeaiiy oa i?iaaea eiiieaenia eieoaaiiy oai?eo aaoeoith
iiaei aio/eciyiei iioiiiiiaeoethth/ei i?aia?aoii “Eaoa?ii” a eiiaiiaoei?
c iaccth “No?aioiiioie”. Aaoi?ii caeieniaii aiaeic, nenoaiaoecaoeiy i
ia?iaea ?acoeueoaoia aeineiaeaeaiue. Ia iniiai io?eiaieo aeaieo
?ic?iaeaii iniiaii iieiaeaiiy aeena?oaoei?. Iaa?oioiaaii iaoeiai
aeniiaee i i?aeoe/ii ?aeiiaiaeaoei?.

Ai?iaaoeiy ?acoeueoaoia aeineiaeaeaiiy. Iniiaii iieiaeaiiy
aeena?oaoeieii? ?iaioe aeiiiaiaeaeenue ia XIII c’?caei Oe?a?inueeiai
iaoeiaiai oiaa?enoaa iie?iaiieiaia, aiiaeaiiieiaia oa ia?aceoieiaia ii.
Ae. E. Caaieioiiai (Ee?a-Aiiieoey, 1996); anaoe?a?inueeie
iaoeiai-i?aeoe/iie eiioa?aioei? 10-?i//th eaoaae?e aeaciioaeoieiai? i
i?ioieaeoeee aioo?ioiueieiea?iyieo iioaeoeie oa i?iaeai aeaciioaeoieiai?
(Oa?eia, 1997); Iiaeia?iaeiie iaoeiaie eiioa?aioei?, i?enay/aii?
110-?i//th Oa?eianueeiai iaoeiai-aeineiaeiiai iinoeoooo iie?iaiieiai? i
iioiieiai? ii. I. I. Ia/ieeiaa “Aeooaeueii ieoaiiy ai?ioueae c
iioaeoeieieie caoai?thaaiiyie” (Oa?eia, 1997); VI-ie anaoe?a?inueeie
eiioa?aioei? caaeaoaae? caaaeueieo oi?o?aie iaaee/ieo aocia Oe?a?ie
(Aiiieoey, 1998); 2-iio Iiaeia?iaeiiio iaaee/iiio eiia?ani nooaeaioia i
iieiaeeo a/aieo (Oa?iiiieue, 1998); 2-iio Eiia?ani oi?o?aia Oe?a?ie
(Ee?a-Aeiiaoeuee, 1998); ia iaoeiai-i?aeoe/iie i iaa/aeueii-iaoiaee/iie
eiioa?aioei? eaoaae? caaaeueii? oi?o?ai? iaae.aocia Oe?a?ie III-IV
?iaiia ae?aaeeoaoei? (Iaeana, 1998). Ia eiioa?aioe?? eaoaae? caaaeueii?
o??o?a??, aini?oaeueii? o??o?a?? oa eaoaae?e ii?nueei? iaaeeoeeie
Iaeanueeiai iaaeoi?aa?neoaoo (1998 ?.).

Ioaeieaoei?. Ca iaoa?iaeaie aeena?oaoei? iioaeieiaaii 13 iaoeiaeo ?iaio,
c yeeo 7 – naiinoieieo.

No?oeoo?a oa ianya aeena?oaoei?. Ciino ?iaioe aeeeaaeaii ia 123
noi?iieao iaoeiiieniiai oaenoo. Aeena?oaoeiy neeaaea?oueny c? anooio,
iaeyaeo eioa?aoo?e, iieno iaoiae?a aeine?aeaeaiiy, 2-o ?icaeie?a aeanieo
aeineiaeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoeie,
iieaae/eea eioa?aoo?e. Oaeno iethno?iaaii (iaethi. 16, oaaeeoeue 23).
Aiaeiia?aoiy neeaaea?oueny ic 209 aeaea?ae, 43 c yeeo iiicaiiith iiaith.

O aiaeiiaiaeiinoi aei caaaeueii? iaoe i iinoaaeaieo caaaeaiue aeaiiai
aeineiaeaeaiiy ia caoeno aeiinyoueny ianooiii iniiaii iieiaeaiiy:

1. Aieea ia i?aaiici ii?yea iaaaoeaieo oaeoi?ia iaaeieeoiueiai
na?aaeiaeua, a oaeiae iiaeaeuaiee iie?io?aaiaoeci ni?eythoue
caieueoaiith caoai?thaaiiy aaoeoith ia oeioi. Na?aae inia iniiaieo
ii?nueeeo i?ioanie iaeaeua caoai?thaaiinoue niinoa?iaa?oueny o
?iaioieeia iaeoaii? eiiaiaee, yei iaeaieueo noeeueii aei aiaeii/aieo
iaaaoeaieo oaeoi?ia.

2. Aaoeoa noi?iaiaeaeo?oueny cia/iei aeenaaeainii iioiii? nenoaie, ui ?
iaeiei ic e?eoa?i?a aaaeeinoi iaoieiai/iiai i?ioeano. Eaoa?ii i?eeia?
o/anoue o iiaeo?eioei noaaieueiinoi iioiii? nenoaie i yaey?oueny ??
ei?aeoi?ii.

3. I?e aaoeni aieueoinoi iie?ii?aaiiciia aeaeieaieo ic ina?aaeea
caiaeaiiy i?eoaiaiia aioeaiioeeinoieeinoue /e aioeaiioeeiiacaeaaeiinoue.
Iinoeaaa canoinoaaiiy iaci ia aiae?ioieueiie iniiai “No?aioiiioie”
aenieiaoaeoeaii ii nai?io aeia?aaeaeoth/iio (a ii?iaiyii c
aioeaiioeeaie) aioeiie?iaiiio aieeao, ui eeiii/ii i?iyaey?oueny o
i?enei?aiii “i?eaeooaiiy” ina?aaeeia caiaeaiiy i nei?i/aiiy no?ieia
aiioaeicaoei? ?ai.

Iniiaiee ciino ?iaioe

Iaoa?iae i iaoiaee aeineiaeaeaiiy. I?aaenoaaeaia aeineiaeaeaiiy aeeiiaii
ia eeiii/iiio iaoa?iaei Iaeanueei? iinueei? iioaeoeieii? eiea?ii,
iinueei? eeiii/ii? eiea?ii N 1 oa oi?o?ai/iiai aiaeaeieaiiy
*i?iiii?nueei? oeaio?aeueii? aanaeiiai? eeiii/ii? eiea?ii ia aiaeiiio
o?ainii?oi ca ia?iiae c 1995-1998 ??. Iioiieiai/ii aeineiaeaeaiiy
aeeiioaaeenue a eaai?aoi?iyo Oa?eianueeiai iaoeiai-aeineiaeiiai
iinoeoooo iie?iaiieiai? oa iioiieiai? ii. I. I. Ia/ieeiaa; a eaai?aoi?i?
eeiii/ii? iioiieiai? Iaeanueeiai iaeaniiai aaia?ieiai/iiai aeeniaina?o.

Aeiaaiic aaoeoe anoaiiaethaaany ia iniiai eeiii/ii? ea?oeie
caoai?thaaiiy, a?aoiaoth/e aiiaeaiiieiai/ii aeaii i ?acoeueoaoe
aaeoa?iieiai/iiai ianoaaeaiiy. I?e anoaiiaeaiii aeiaaiico a?aoiaoaaee
oi?io i oyaeinoue ia?aaiao, iayaiinoue noi?iaiaeaeoth/eo caoai?thaaiue i
oneeaaeiaiue.

Aeey ?aaeicaoei? iinoaaeaieo caaea/, ii?yae ic caaaeueiii?eeiyoeie
eeiii/ieie i eaai?aoi?ieie aeaieie (aiaeic e?iai i na/i), i?iaiaeeee
aaeoa?iieiai/iee iinia ic aeaeieyth/iai ?aie c iineiaeoth/ith
iaeaioeoieaoei?th aeaeieaieo noi?iaiaeaeoth/eo iie?ii?aaiiciia i
aecia/aiiyi /ooo?ainoi aei ieo aioeaiioeeia. Aaeoa?iieiai/ia
aeineiaeaeaiiy i?iaiaeeee a aeeiaiioei: ia ii/aoeo caoai?thaaiiy aei
aioeaiioeeioa?aii? i ia?aae aeieneith ic noaoeiiia?a.

Ie niinoa?iaaee 190 oai?eo aaoeoith, o oiio /enei 70 ii?yeia, c yeeo 1-a
a?oia – 100 iaoei?ioia eieoaaeenue caaaeueiii?eeiyoeie caniaaie
(aioeaiioeee, aioeainoaiiiii i?aia?aoe, aioaiiie), 2-a a?oia c 90 oai?eo
aeiaeaoeiai aei i?iaaaeaiiai eieoaaiiy io?eioaaea eaoa?ii ii 3 iei. II 1
?ac aioo?ioiueii’yciai i?ioyaii 5-7 aeiia.

Ca ioeiieith e?aoiinoi, oi?i i oneeaaeaiiy aaoeoe ei?enooaaeenue
eeaneoieaoei?th, yeo cai?iiiioaaa A. E. *a?eania (1977 ?.) a iaoiaee/ieo
?aeiiaiaeaoeiyo.

Oaaeeoey ? 1

Eeiii/ia oa?aeoa?enoeea ianoaaeaieo oai?eo ia aaoeoo

Iieacieee Oai?i, yei io?eiaee eaoa?ii A?oia niianoaaeaiiy

*enei ianoa-aeaieo oai?eo 90% 100%

Noaoue: /ieiai/a 26% 30%

  aeiii/a 64% 70%

Aaaeeinoue ia?aaiao caoai?thaaiiy

Eaaea 22% 26%

Na?aaeiuei? aaaeeinoi 56% 64%

Aaaeea 12% 10%

E?aoiinoue oai?iae

Ia?aeiia 63.7% 65.6%

Iiaoi?ia 20.2% 20.0%

?aoeeaeeaoth/a 16.1% 14.4%

Eieaeicaoeiy iinoeaaiai i?ioeano

Ieaeii eiioeiaee 83.7% 85.4%

Iaee//y 6.3% 5.3%

Aa?oii eiioeiaee 10% 9.3%

Oi?ia caoai?thaaiiy

A?eoaiaoicia 10.4% 11.2%

A?eoaiaoicii-aaii?aai/ia 3% 4%

A?eoaiaoicii-aoeueicia 61.2% 64.0%

Aoeueicii-aaii?aai/ia 25.4% 20.8%

Aeiaaiic anoaiiaethaaany ia iniiai aeaieo aiaiiaca, aino?iai ii/aoeo c
?icaeoeii iioieneeaoeieiiai neiae?iio (eeoiiaiea, aieiaiee aieue,
neaainoue, oeiiaeo ciii a iinoeaaiio ina?aaeeo o?aaeaiiy oei?e,
iaa?yeaiiy, aiia?aiiy c ia?iaieie /ioeeie iaaeaie, aaii?aai?, aoeee,
?aaiiia?iee eiioaaeaiio).

Aiaeic iioiia?ai oai?eo aei i iiney eieoaaiiy i?iaiaeeee aiaeiiaiaeii c
?aeiiaiaeaoeiyie E. A. Eaaaaeaaa i I. Ae. Iiiyeiii? “Eiioiia?aiia a
eeeie/aneie i?aeoeea” (I., “Iaoea”, — 1990).

Aeioeieueiinoue i?ecia/aiiy iioiiiei?aaoth/i? oa?aii? oai?ei aaoeoith ca
aeiiiiiaith eaoa?iia aecia/aee oeyoii aaeaa?ain-oanoa “in vitro” a
iiaeeoieaoei? I. A. Ia?anaaeiia (1985).

Aoaeoeaiinoue eaoa?iiioa?aii? ioeiithaaee iioiieiai/ieie iieacieeaie,
oeyoii aecia/aiiy iioa?oa?iia (IOI a ne?iaaooei e?iai a aeeiaiioei aei i
iiney i?iaaaeaiiy eieoaaiiy ii i?eaii/aiith oeeoiiaoiaaiii? aei?
oano-ai?ona a eoeueoo?i eeioei (J.E.Enders, 1959). sse iiaeeeaoi?iee
ai?on aeei?enoiaoaaee ai?on aaceeoey?iiai noiiaoeoa, yeee iana?oaaee a
ia?aeiiie eoeueoo?i oia?iieanoia aia?iiia ethaeeie i ia?ai?eaeaath/i?
eoeueoo?e eaeeioeeoia ethaeeie L-41.

Aeey noaiaea?oecaoei? io?eiaieo ?acoeueoaoia aeei?enoiaoaaee ethaenueeee
eaeeioeeoa?iee ?aoa?ain-i?aia?ao iioa?oa?iia ?-5.

Noaoenoe/ia ia?iaea ?acoeueoaoia aeineiaeaeaiiy i?iaiaeeeanue iaoiaeii
iaoaiaoe/ii? noaoenoeee c ae/eneaiiyi na?aaeiuei? a?eoiaoe/ii? i
na?aaeiuei? iiieeee na?aaeiuei? a?eoiaoe/ii?. Ia?iaea aeaieo
iioiieiai/ieo aeineiaeaeaiue i?iaiaeeeanue ca i?aaeeii iiia?ii ca’ycaieo
aa?iaioia c ia/eneaiiyi na?aaeiuei? ?ica?aeiinoi i na?aaeiuei? iiieeee
?icaiaeiinoi. Aeinoiai?iinoue ?acoeueoaoia ioeiithaaeanue ca e?eoa?i?i
Nouethaeaioa.

?acoeueoaoe iioiieiai/ieo aeineiaeaeaiue, i?iaaaeaii a aeeiaiioei
caoai?thaaiiy aaoeoith i?e ?icieo eeiii/ieo oi?iao, aeyaeee neiaeoth/a:
caaaeueia eieueeinoue O-eiioioeeoia (A-?IE %) a aino?iio ia?iiaei
aeinoiai?ii cieaeoaaeanue, neeaaeath/e a na?aaeiueiio 49±0.7, a oie /an,
ye oeae iieaciee o caei?iaeo neeaaeaa 65%. 1.5o109/e, ?<0.01. Anoaiiaeaiii, ui nooiiiue cieaeaiiy ?iaiy A-?IE caeaaeaa aiae iniaeeainoae ia?aaiao iioaeoeieiiai i?ioeano, iayaiinoi noi?iaiaeaeoth/i? iaoieiai? oa oneeaaeiaiue i?e aaoeni. Iaeaieueo ae?aaeaia cieaeaiiy /enea O-eiioioeeoia aiaeii/aeinue o oai?eo c ?icaeiooeie a aino?iio ia?iiaei (o 13 iaoei?ioia) oneeaaeiaiue aiieii-naioe/iiai oa?aeoa?o (oeaaiiia, aanoean, o?iiaioeaaio iiaa?oiaeo aai aiiieee). 31±0.5%; 0.30±0.2o109/e ?<0.01. I?e iaoneeaaeiaiiio ia?aaiao ia?aeiii? i iiaoi?ii? aaoeoe /enei O-eiioioeeoia aei iiiaioo aeienee iaaeeaeaeinue aei aieiai? ii?ie 0.85±0.1o109/e. O oai?eo ia?aeiii? aaoeoe i?e iayaiinoi iiii?ieo ciii a iinoeaaiio ina?aaeeo ii i?ioeaioiiio i aaniethoiiio aiinoo na?aaei? /enei O-eeioei neeaei 45±3%, 0.54±0.04o109/e, aiaeiiaiaeii i?e yaiie noi?iaiaeaeoth/ie iaoieiai? c ?? /ioeith eeiii/iith iaiioanoaoei?th (oeoe?iaee aeiaaao, iaee?iiiy, neiiiainoue, o?iii/ia aaiicia iaaeinoaoiinoue) eieueeinoue O-eiioioeeoia aoei cieaeaii iaeaieueo nooo?ai i ?o aaniethoiee i aiaeiiniee aiino neeaaeaa 30±3%/0.40±0.03o109/e. Ciaeaeaii oaeiae ?icieoeth ?iaiia A-?IE a a?oiao oai?eo iioeeiai i noa?iai aieo. O inia iioeeiai aieo  O-eeioei neeaaeaei a aino?iio ia?iiaei a na?aaeiueiio 38±4 /0.48±0.05o109/e ?<0.05 o i?enoa?ieeo oai?eo 29±3% /e 0.3±0.4o109/e. O oai?eo iioeeiai i noa?iai aieo aaoeoa niinoa?iaaeanue cia/iei /eneii noi?iaiaeaeoth/eo oai?ia, i aiie iaee, ye i?aaeei, aieueo ae?aaeaiee nooiiiue eeiii/ii? iaiioanoaoei? ii iciaeai iayaiinoi caiaethaaeueiiai i?ioeano i?e aaoeni. Eieueeinoue O-eiioioeeoia o oai?eo noa?oeo 60-oe ?ieia a na?aaeiueiio neeaei 32±0.4% /0.4±0.02o109/e. O aieiaeo a?oiao aei 60-oe ?ieia oeae iieaciee aoa aeinoiai?ii aeuee a ii?iaiyiii c a?oiith aieueo iioeeiai aieo i neeaaeaa 40±0.4% i /0.6±0.05o109/e, ?<0.05 ii aiaeiiniiio i aaniethoiiio aiinoo aiaeiiaiaeii. ?iaaiue A-eeioei i?aeoe/ii ia ciiithaaany i?e ?icieo oi?iao aaoeoe i a na?aaeiueiio neeaa 21±3%, ?<0.01. Iaeiae a oeieiio iaoieiai/ii c?ooaiiy o aiinoi oioaeueii? iiioeyoei? A-eiioioeeoia a aino?iio ia?iiaei aaoeoe aoee iaaaeeei a ii?iaiyiii c eiio?ieueieie i ?iciiiai?aaeaieie a caeaaeiinoi aiae eeiii/ieo oi?i aaoeoe. ?acii c oei i?e ia?aeiiie i iiaoi?iie aaoeni /enei O-eiioioeeoia iiiaei iaaeeaeaeinue aei ieaeiuei? iaaei ii?ie: 1.07±0.2o109/e, a i?e /anoi ?aoeeaeeaoth/ie aaoeni aiii caeeoaeinue aeinoiai?ii cieaeaiei: 0.43±0.04o109/e, 38±4% ?<0.01 i iiaa?iaiiy oeueiai iieacieea aei ii?ie ia niinoa?iaaeinue. ?iaaiue I-eiioioeeoia cieaeoaaany ia?aeaeueii ic iienaieie aeua ciiiaie /enea O-eeioei a caeaaeiinoi aiae eeiiiee aaoeoe, a oie /an i?e ?aoeeaeeaoth/ie aaoeni eieueeinoue I-eeioei caa?iaaeinue ia aenieeo oeeo?ao i naiae/eei i?i aoaeoeaiinoue niaoeeoi/ii? iioiieiai/ii? aiaeiiaiaei. Nooo?ai ciiie aeyaeaii oaeiae i?e aeineiaeaeaiii noaiiioeyoei? oaioieiicaeaaeieo O-eiioioeeoia. ?iaaiue O-oaeia?ia (OO?) aeinoiai?ii cieaeoaaany, i?e /iio nooiiiue oeueiai cieaeaiiy caeaaeaea aiae eeiii/ii? oi?ie caoai?thaaiiy i iayaiinoi noi?iaiaeaeoth/i? iaoieiai?. Eieueeinoue (OO*) eeioei O-noi?ani?e, iaaiaee, o aieueoinoi ianoaaeaieo oai?eo aoei o iaaeao aieiai? ii?ie /e iiii?ii iiaeaeuaiei. O ca’yceo c oeei iiiyeinue niiaaiaeiioaiiy O-oaeia?ia/O-noi?ani?ia o oai?eo aaoeoith. Oei aeaii naiae/aoue i?i oi?ioaaiiy aiaeiiniiai noi?ani?iiai aa?iaioa aoi?eiii? iioiieiai/ii? iaaeinoaoiinoi o oai?eo aaoeoith i i?i eiai aieueo cia/io ae?aciinoue i?e ?aoeeaeeaoth/iio ia?aaiao caoai?thaaiiy. Iioiiaeiaoe?ie (Ig) ne?iaaoee e?iai eeania A, M, G aea/aii o 90 oai?eo aaoeoith. I?e ia?aeiiie i iiaoi?iie aaoeni o ?iciae oai?iae aeinoiai?ii iiaeaeuoaaany ?iaaiue iioiiaeiaoeiiia eeania: M - 2.0±1.5 a/e, ?<0.05; G - 12.2±0.9 a/e, ?<0.05 a ii?iaiyiii ic caei?iaeie iniaaie, a oie /an, ye aiino Ig A ia aeoiaeea ca aa?oith iaaeo ii?ie - 2.20±0.88, ?<0.01 i neeaei 1.9±2.5 a/e. A ia?iiae ?aiiuei? ?aeiiaaeinoeaioei? ?iaaiue Ig A i Ig M aeaui c?inoaa, ui naiae/eoue i?i aeoeaaoeith aoii?aeueieo iaoaiiciia, aeineiaeaeaieo o oai?eo aaoeoith a ia?iiae iaeoaeaiiy. C iaoith aea/aiiy iaoiaaiaoe/ii? ?iei OeIE i?e aaoeni ianoaaeaii 90 iaoei?ioia c ?icieie eeiii/ieie caoai?thaaiiyie. I?e oeueiio anoaiiaeaii, ui ia ?iaaiue OeIE aieeaaea, ia?o ca ana, /anoioa ia?aaeoth/eo ?aoeeaeeaia i iayaiinoue noi?iaiaeaeoth/i? iaoieiai?. A aino?iio ia?iiaei i iiaoi?ii? aaoeoe aeyaeaii iiaeaeuaiiy ?iaiy OeIE, yea noaiiaeei a ?iciae oai?iae o na?aaeiueiio: 18.3±1.8, 13±1.1, ?<0.05. Aiaeiiaiaeiee iieaciee o caei?iaeo o ii?ii 0-10. I?e aiaenooiinoi ?aoeeaeoaaiiy /e ?iaeeeo ?aoeeaeeaao aei iiiaioo aeienee oai?iai aiaeaoaaeinue cieaeaiiy ?iaiy OeIE c oaiaeaioei?th aei ii?ie: 15.2±1.5; 11.2±1.1, ?<0.05. I?e ?aoeeaeeaoth/ie aaoeni a aino?iio ia?iiaei (o 15 oai?eo) iiaeaeuaiiy ?iaiy OeIE aoei aieueo ae?aaeaii: 41.2±4.1; 26.6±2.1, ?<0.001. ?iaaiue OeIE o oai?eo aei 60-oe ?ieia neeaa o aino?iio ia?iiaei a na?aaeiueiio 18.0±1.8;13.1±1.3, ?<0.01, a a iioeeiio i noa?iio aioei (noa?oi 60-oe ?ieia) - 22.7±2.3; 18.4±1.8, ?<0.05. I?iaaaeaiee aiaeic io?eiaieo ?acoeueoaoia ic noaoenoe/iith ia?iaeith aeaieo aeey iiia?ii ca’ycaieo aa?iaioia a a?oii, io?eiaaoeo eaoa?ii, aeicaieea anoaiiaeoe aeinoiai?ii aiaeiiiiinoi a nenoaii eeioeiiiai i aoii?aeueiiai iioiioaoa. Oaeei /eiii, c?iaeaia ioeiiea noaio iioiii?aaeoeaiinoi i?aaiicio. Ioeiiea ii?iaiyiiy noaio iioiieiai/iiai noaoono ii aiaeiioaiith aei iieacieeia iioiiia?aie o caei?iaeo inia. Ioeiiea iioiii?aaeoeaiinoi i?aaiicio a ianoaaeaieo oai?eo ia aaoeoo aei i iiney eieoaaiiy eaoa?iiii iieacaea, ui aeinoiai?ii aiaeiiiiinoi aei noaio iioiiiai noaoona aiae?iciythoueny ii oaeei iieacieeai, ye O-oaeia?ia i O-noi?ani?ia aeoeaiinoue, oaaioeeoa?ia /enei, oaaioeeoa?ia aeoeaiinoue, aiino Ig A, M, G a ne?iaaooei e?iai i ?icieoey O-aeoeaieo A-?IE. Eeiii/ii aeineiaeaeaiiy aoaeoeaiinoi iaci “No?aioiiioie” i?iaiaeeeenue a ii?iaiyeueiiio aniaeoi c aoaeoeaiinoth oa?aii? aaoeoe aioeaiioeeaie o 90 oai?eo. A I-e a?oii ic 55 /ieiaie eieoaaiiy i?iaiaeeeenue ca caaaeueiii?eeiyoith noaiith: aioeaiioeee, aioeainoaiiiii i?aia?aoe, noeueoaiieaiiaee, eaoa?ii ii 3 iei IA 1 ?ac a aeaiue aioo?ioiueii’yciai i?ioyaii 5-7 aeiia, aeaceioieneeaoeieia oa?aiiy, OOI, ia?aa’ycee c aeei?enoaiiyi oo?aoeeeiia 1:5000, oei?aaeneaeeia. O II-e a?oii 35 /ieiaie - aeiaeaoeiai aei iienaiiai eieoaaiiy iinoeaai canoiniaoaaee 1 ?ac ia aeiao iacue “No?aioiiioie” ia a?icieii iiaa?oii i aoeee, yei aiaee?eeenue iiney ia?iaee ?ic/eiii oo?aoeeeiia 1:5000 iacue iaiineee ia ia?eaao iia’yceo oiieei oa?ii 1 ?ac ia aeaiue. Aeey aecia/aiiy /ooo?ainoi iie?iaii? oei?e a ina?aaeeo caiaeaiiy aei “No?aioiiioieo” i iniiaiei aioeaiioeeii aoei i?iaaaeaii aaeoa?iieiai/ia aeineiaeaeaiiy 67 oai?eo ic ?icieie oi?iaie aaoeoe. Aei ii/aoeo eieoaaiiy i i?e inoaiiueiio eiio?ieueiiio ianoaaeaiii aoee i?iaaaeaii aaeoa?iieiaiyii oanoe. Ianiyiinoue ?ai cia/ii ciaioeeanue, ui aeaco? ia aioeiie?iaio aeith i?aia?aoa. Iiai/ieo aoaeoia ia aeyaeeinue. Iaeoaeaiiy /e iie?auaiiy ianooieei o 90 % oai?eo, noai ia ciiieany o 10%. Aea?ai/ieo ?aaeoeie ia aiaeii/aeinue. Oai?i eaaei canai?ee oaoiieo naiinoieiiai eieoaaiiy. C iaoith aea/aiiy aeeiaiiee caai?iiy ?ai o ae?oaie oaci ?aiaaiai i?ioeano iiae aieeaii caaaeueiii?eeiyoeo i?aia?aoia iaie ianoaaeaii 65 oai?eo. Aeey eieoaaiiy oai?eo a eiio?ieueiie a?oii aeei?enoiaoaaee ?ic/ei oo?aoeeeiio 1:5000, iacue Aeoiaanueeiai, aiia?oiii/iee ?ic/ei NaCl (10% i 5%). Iiae /an ia?aa’ycie o ae?oaie oaci ?aiaaiai i?ioeano ie ia i?iieaaee ?aie ?ic/eiii ia?aeeno aiaeith, yeee, ia iaoo aeoieo, i?eiiea? a?aioeyoei?. Aeey i?iieaaiiy ?ai aeei?enoiaoaaee ?ic/eie aeaoa?aaioia, a oaeiae ?ic/ei oo?aoeeeiio. Aeeiaiieo caaithaaiiy ?ai o ae?oaie oaci ?aiaaiai i?ioeano aea/eee ia 50-oe oai?eo oeyoii aecia/aiiy ia’?io ii?iaeieie i ieiui ?ai. Aeineiaeaeaiue ii aecia/aiith ?inoo a?aioeyoeie i?iaaaeaii 100, ii aecia/aiith aiioaeicaoei? ?ai - 150. A ?acoeueoaoi iaie anoaiiaeaii, ui ?ino a?aioeyoei? ca iaeio aeiao iiae aieeaii ?ic/eio oo?aoeeeiio neeaa 7.0 ± 0.7%, aiioaeicaoeiy - 6.4 ± 0.6%. Iiae aieeaii iaci Aeoiaanueeiai aeiaiaee ?ino a?aioeyoei? neeaa - 8.4 ± 0.7%, aeiaiaa aiioaeicaoeiy - 6.3% ± 0.4%. Iiae aieeaii aiia?oiii/iiai ?ic/eio NaCl aeiaiaee ?ino a?aioeyoeie aei?iaithaaa - 2.3% ± 0.5%, aiioaeicaoeiy -0.2 ± 0.7%, oaae. ? 2. Oaaeeoey ? 2 Aieea ?icieo i?aia?aoia ia caaithaaiiy ?ai ? I?aia?ao I?ioeaio ?inoo I?ioeaio aiioaeicaoei? ca ca iaeio aeiao iaeio aeiao 1. Oo?aoeeeii 7.0 ± 0.7 6.4 ± 0.6 2. Iacue Aeoiaanueeiai 8.4 ± 0.7 6.3 ± 0.4 3. Aiia?oiii/iee ?ic/ei 2.3 ± 0.5 0.2 ± 0.7 4. Aiae?ioieueia iacue 14.7 ±0.8 11.6 ± 0.5 A ?acoeueoaoi i?iaaaeaieo aeineiaeaeaiue iaie anoaiiaeaii, ui aeiaiaa aeeiaiiea ?inoo a?aioeyoei? iiae aieeaii iaci ia aiae?ioieueiie iniiai “No?aioiiioie” neeaa 14.7 ± 0.8%, aeeiaiiea aiioaeicaoei? - 11.6 ± 0.5%. Aeeoa?aioeieiee aeai? iaoiaeia iinoeaaiai eieoaaiiy aeicaieea nei?ioeoe o?eaaeinoue eieoaaiiy oai?eo a ii?iaiyiii c eiio?ieueiith a?oiith o aeaa ?ace. Na?aaeiie no?ie eieoaaiiy oai?eo ic canoinoaaiiyi o?aaeeoeieieo i?aia?aoia neeaa - 21 ± 5 aeiia, ic canoinoaaiiyi iaci “No?aioiiioie” - 14 ± 3 aeiy. Oai?eo iaio a?oi aeienoaaee ic noaoeiiia?o iiney iiaiiai caaithaaiiy ?ai. No?iee ia?aaoaaiiy oai?eo ia eiea?iyiiio eenoi oaeiae nei?i/oaaeenue o aeaa ?ace. Iaiaoiaeii oaeiae aiaeiioeoe, ui iiae aieeaii aiae?ioieueii? iaci iiaiinoth i?eieiythoueny aieueiai aiae/oooy a iaeanoi ?ai. ssaeua caiaeaiiy iaaeiei ?ai aiaenooii. /Ioaea, ii?iaiyeueiee aiaeic aeeiaiiee ?aa?ani? eeiii/ieo i?iyaia aaoeoe i?e o?aaeeoeieieo iaoiaeao iinoeaaiai eieoaaiiy i iaci “No?aioiiioie” aeyaea aeinoiai?ii iiceoeaiee aieea ia ia?aaia caoai?thaaiiy. Aiaeaeaeaii ?acoeueoaoe eiiieaeniiai eieoaaiiy ii?yeia, yei no?aaeaeathoue aaoeoith no?ieii aiae 1 aei 5 ?ieia aea/aii o 62 oai?eo, a oiio /enei o 30-oe oai?eo iiney o?aaeeoeieieo iaoiaeia oa?aii? i o 32-o iiney eiiieaeniiai eieoaaiiy eaoa?iiii i no?aioiiioieii. Oi?ioee ?acoeueoao (aiaenooiinoue ?aoeeaeeao caoai?thaaiiy, ii?iaeueia ooieoeiy eiioeiaie) niinoa?iaaany o 12 oai?eo (40%) ia?oi? a?oie i o 21 oai?eo (65.6%) - ae?oai? a?oie. Caaeiaieueiee ?acoeueoao (iaeei) ?aoeeaeea caoai?thaaiiy aac ii?ooaiiy ooieoei? eiioeiaie aiaeii/aiee aiaeiiaiaeii o 10 (33.3%) i o 8 (25%) oai?eo. Iacaaeiaieueiee ?acoeueoao (iiaoi?ii ?aoeeaeeae, neiiiainoue, ii?ooaiiy ooieoei? eiioeiaie, iiaaeiaeecaoeiy) aiaeii/aany aiaeiiaiaeii o 8 (26.7%) i o 3 (9.4%) oai?eo. Aeineiaeaeaiiyi no?ieia iiaa?iaiiy oai?eo aei ?iaioe ii niaoeiaeueiinoi ia oeio? anoaiiaeaii, ui /a?ac 4-6 iinyoeia i?enooieee 8 (26.6%) oai?eo, /a?ac 9-12 iinyoeia - 13 (43.3%). 9 oai?eo aiaeiiaeeenue aiae iiaeaeueoi? ?iaioe ia noaeiao ii?nueeiai o?ainii?oo. Ic 32 ianoaaeaieo oai?eo ae?oai? a?oie /a?ac 4-6 iinyoeia aei ?iaioe ca oaoii iiaa?ioeenue 14 (43.7%) oai?eo, /a?ac 9-12 iinyoeia oaeiae 14 (43.7%) oai?eo. 4 oai?eo caeeoeee ?iaioo ia ii?nueeiio oeioi. Oaeei /eiii, ?acoeueoaoe eieoaaiiy oai?eo aaoeoith o cia/iie ii?i ca’ycaii c aeai?ii oaeoeee eieoaaiiy. Aeeoa?aioeieiee aeai? aaeaeaaoii? aioeaaeoa?iaeueii?, iioiiiiiaeoethth/i? oa?aii? i iinoeaaiai eieoaaiiy aeicaieea aeinyaoe oi?ioeo i caaeiaieueieo ?acoeueoaoia o 96.2% oai?eo. Aieueo, iiae 90% ii?ye?a, yei io?eiaee eiiieaenia eieoaaiiy c i?eaiaeo aaoeoe, aoee i?ioanieii ?aaaieioiaaii a no?iee aiae 4 aei 12 iinyoeia. Aeniiaee 1. A ?acoeueoaoi aieeao ia i?aaiici ii?yeia iaaaoeaieo oaeoi?ia noa?e aeeooy i i?ioanieii? aeiyeueiinoi, o ieo ?icaeaa?oueny ii?ooaiiy neeaaeiiai eiiieaeno caoenii-i?enoinoaaeueiiai iaoaiicio aei ?iaioe o Naioiaiio ieaaii, ui aeyaey?oueny o aeaeyaei ciii ineoieiai/ii?, oice/ii? oa iioiieiai/ii? ?aaeoeaiinoi i?aaiicio. Oei ciiie ?acii c iiaeaeuaiei iie?io?aaiaoeciii ia ii?nueeiio oeioi ni?eythoue caieueoaiith ?iaiy caoai?thaaiinoi aaoeoe na?aae ii?yeia, yeee neeaaea? 6-8 /ieiaie ia 1000 ?iaioieeia ii?nueeiai o?ainii?oo i, oaeei /eiii, aieueo iiae a 2 ?ace ia?aaeuo? caoai?thaaiiy na?aae ethaeae iaii?nueeeo i?ioanie. 2. Iaeaieueo aeniea caoai?thaaiinoue aaoeoith na?aae inia iniiaieo ii?nueeeo i?ioanie niinoa?iaa?oueny o ?iaioieeia iaeoaii? eiiaiaee, iniaeeai ?yaeiaiai neeaaeo - iao?inia, iaeaieueo iiaeaeaoeeaeo iie?io?aaiaoecio, ia?aioieiaeaeaiith iiae /an oaa?oiaee, aeiaaio?eaaei? ?iaioe ia aiaee?eoie iaeoai oa aieeao oaeoi?ia caaaeueiiai ii?yaeeo. Caoai?thaaiiy aaoeoith o ?iaioieeia iaeoaii? eiiaiaee o 2 ?ace ia?aaeuo? caoai?thaaiinoue aeaiith oai?iaith na?aae ?iaioieeia iaoeiii? eiiaiaee i a 5 ?acia - na?aae ianeoaiaoth/iai ia?niiaeo. ?yaeiaee neeaae iaeoaii? eiiaiaee o 2.5 ?ace /anoioa oai?i? aaoeoith o ii?iaiyiii c eiiaiaeiei neeaaeii. 3. O ii?yeia, yei no?aaeaeathoue aaoeoith, niinoa?iaathoueny ae?aaeaii ciiie iioiieiai/ii? ?aaeoeaiinoi: c aieo eeioeiiiai eaioethaa aiaeii/a?oueny caieueoaiiy eieueeinoi ?icaoeiooai?thth/eo eeioei (?IE), cieaeaiiy eieueeinoi O-eiioioeeoia, oeae iieaciee a aino?ie noaaei? caoai?thaaiiy a na?aaeiueiio aei?iaithaaa 49 ± 0.7%, a eiio?ieueiie a?oii (caei?iai) aii neeaaeaa 65%. Aoii?aeueiee eaioetha iioiioaoo i?e aaoeni oa?aeoa?eco?oueny iiaeaeuaiei ?iaiai iioiiaeiaoeiiia (Ig). Canoinoaaiiy iioiiiiiaeoeyoi?a - eaoa?iia a aeici 3 iei II 1 ?ac ia aeaiue ni?eyei aeinoiai?iie ii?iaeicaoei? iieacieeia eeioeiiiai i aoii?aeueiiai iioiioaoo. 4. I?e aaoeni nooiiiue i oa?iii ii?ooaiue c aieo eeioeiiiai eaioethaa iioiioaoo ei?eaothoue ci noaaeai ?iaioe ii?yeia ia ii?nueeiio o?ainii?oi, aieii oai?eo, iayaiinoth noi?iaiaeaeoth/eo oai?ia i /anoioith ?aoeeaeeaia aaoeoe. Aeei?enoaiiy iioiieiai/iiai iaoiaeo aecia/aiiy /ooo?aino? iioiioeeoia aei eaoa?iio aeicaieeei iiaeaeueoe aoaeoeaiinoue eieoaaiiy (i?e ioeiioei eiai ca eeiii/ieie iieacieeaie i aeeiaiioei iioiinoaoono oai?eo) a na?aaeiueiio o 2 ?ace. 5. I?e aaoeni eaoa?iiioa?aiiy o eiiieaeni c iinoeaaei eieoaaiiyi iaci “No?aioiiioie” aiaeii/a?oueny ei?aeoeiy iioiiiiaoieiai/ieo c?ooaiue (aeoeaaoeiy O-oaeia?ii? i O-noi?ani?ii? aeoeaiinoi, oaaioeeoica, ii?iaeicaoeiy ?iaiia iioiiaeiaoeiiia) oa ii?ooaiiy iinoeaaiai iioiioaoo, ui i?iyaey?oueny a iiaeaeuaiiio aiinoi nae?aoi?iiai iioiiaeiaoeiio A a ne?iaaooei e?iai. 6. Canoinoaaiiy eaoa?iiioa?aii? oa ?? ii?aeiaiiy c iaccth “No?aioiiioie” o oai?eo aaoeoith i?eaiaeeoue aei iiceoeaii? eeiii/ii? aeeiaiiee, ui i?iyaey?oueny o nei?i/aiii oa?iiio ia?iiaeo eeoiiaiee, aieaaiai neiae?iio, iinoeaaeo caiaethaaeueieo ciii, caaaeueiith iioieneeaoei?th, no?ieii eieoaaiiy oai?eo o noaoeiiia?i i cia/iei ciaioaiiyi /anoioe ?aoeeaeeaia oa oneeaaeiaiue. 7. Aaciina?aaeii oa aiaeaeaeaii ?acoeueoaoe aaoeoe o cia/iie ii?i ca’ycaii c aeai?ii ?aoeiiiaeueii? oaeoeee eieoaaiiy. Aeeoa?aioeieiee aeai? aioeaaeoa?iaeueii? iioiiiiaeoethth/i? oa?aii? aeicaieea aeinyaoe oi?ioeo i caaeiaieueieo ?acoeueoaoia o 96.2% oai?eo. Aieueo iiae 90% ii?yeia, yei io?eiaee eiiieaenia eieoaaiiy eaoa?iiii i no?aioiiioieii, iiaeeyaathoue i?ioanieiie ?aaaieioaoei? a no?iee aiae 4 aei 12 iinyoeia. 8. O aiaeaeaeaiiio ia?iiaei ?aaaieioaoei? oai?eo aaoeoith ooieoeiiiaeueii iieacieee noaio iioiioaoo (eeioeiiiai i aoii?aeueiiai) aieueo aeniei o a?oii, aea a eiiieaenia eieoaaiiy aeeth/aany eaoa?ii i no?aioiiioie. I?aeoe/ii ?aeiiaiaeaoei? 1. C iaoith iaeaieueo iioeiaeueiiai i?iaaaeaiiy eiiieaeniiai eieoaaiiy ii?yeia, oai?eo ia aaoeoo, a eiiieaen eieoaaeueieo caoiaeia iaiaoiaeii aaiaeeoe iioiiiiiaeoeyoi? - eaoa?ii, yeee neiae aeei?enoiaoaaoe o aeaeyaei aioo?ioiueii’yciaeo ii’?eoeie ii 3 iei II 1 ?ac ia aeaiue i?ioyaii 5-7 aeiia. 2. I?e i?iaaaeaiii iioiiiei?aaoth/i? oa?aii? eaoa?iiii c iaoith eiio?iey aoaeoeaiinoi eieoaaiiy neiae aecia/eoe /ooo?ainoue aei eaoa?iia. 3. C iaoith iioeiicaoei? eieoaaeueiiai i?ioeano i?e aaoeni aeioeieueii aeeth/aoe iinoeaaa canoinoaaiiy iaci ia aiae?ioieueiie iniiai - “No?aioiiioie”, yea ia? ae?aciee aioeaaeoa?iaeueiee, i?ioecaiaeueiee, aiioaeicoth/ee aieea. 4. ?aeiiaiaeiaaia eiiieaenia oa?aiiy aio/eciyieie i?aia?aoaie “Eaoa?iiii” i “No?aioiiioieii” a?aoiaioiaaia aeiiiii/ii ca i?eioeeiii “iecueea oeiia - aeniea yeinoue”. Nienie i?aoeue, iioae?eiaaieo ca oaiith aeena?oaoe?? 1. Eoi?aoa A.ss. I?eiaiaiea eaoa?iia a eiiieaeniie oa?aiee aieueiuo ?iaeae //A?niee i?iaeai a?ieia?? ? iaaeeoeeie. - Iieoaaa-Oa?e?a. - 1998. - N16. - N. 117-120. 2. Eoi?aoa A.ss., Caii?iae/aiei A.N., Ai?aoiia A.A. Iieieaiiniay aoeeacii-iae?ioe/aneay oi?ia ?iaeenoiai ainiaeaiey // A?niee ii?nueei? iaaeeoeeie.-1998. - N1. - N. 78-80. 3. Eoi?aoa A.ss., Caii?iae/aiei A.N. Nia?aiaiiua i?eioeeiu ianoiiai ea/aiey ?iaeenoiai ainiaeaiey a oneiaeyo ieaaaiey //A?niee ii?nueei? iaaeeoeeie. - 1998. - N2. - N. 41-44. 4. Eoi?aoa A.ss. , E?oa?iia I.A. I?iaeaie ai?eieo oneeaaeiaiue aaoeoe ye oaeoi? iia??oaiiy aeieia?/ii? neooaoe?? o e?a?i? //A?niee ii?nueei? iaaeeoeeie. - 1998. - N3. - N. 56-60. 5. Eoi?aoa A.ss. ?acoeueoaou eeeie/aneie ai?iaaoeee ioa/anoaaiiiai i?aia?aoa “Eaoa?ii” i?e ea/aiee ?iaeenoiai ainiaeaiey //A ca.: Iaoa??aee VI-? anaoe?a?inueei? eiioa?aioe?? caaeaoaae? caaaeueieo o??o?a?e iaaee/ieo aoc?a Oe?a?ie. A?iieoey. - 1998. - N. 123-124. 6. Eoi?aoa A.ss. I?eiaiaiea eaoa?iia a eiiieaeniie oa?aiee aieueiuo ?iaeenoui ainiaeaieai //Oacenu aeiee. Iaaeaeoia?iaeiie iao/iie eiioa?aioeee, iinayuaiiie 110-eaoeth Oa?ueeianeiai iao/ii-enneaaeiaaoaeueneiai einoeoooa iee?iaeieiaee e eiioiieiaee ei.E.E.Ia/ieeiaa. “Aeooaeueiua aii?inu ai?ueau n eioaeoeeiiiuie caaieaaaieyie”. - Oa?ueeia. -1997. - N. 42-43. 7. Eoi?aoa A.ss., Iai/aiei E.I. Aeooaeuei? ieoaiiy i?iaeaie ai?eieo oneeaaeiaiue aaoeoe //Oac. aeii. XIII c’?caeo Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a oa ia?aceoieia?a ?i. Ae.E.Caaieioiiai. - Ee?a-A?iieoey. - 1996. - N. 193. 8. Eoi?aoa A.ss. Eiioiieiae/aneay ?aaeoeaiinoue o aieueiuo ?iaeenoui ainiaeaieai e ei??aeoeey aa ia?ooaiey n iiuueth eaoa?iia //A ca.: Iaoa??aee anaoe?a?inueei? iaoeiai-i?aeoe/ii? eiioa?aioe??, i?enay/aii? 10-??//th eaoaae?e aeac?ioaeoieia?? ? i?io?eaeoeee aioo??oiueie?ea?iyieo ioaeoe?e Oa?e?anueeiai ?inoeoooo oaeineiiaeaiiy e?ea??a. “Aeooaeuei? ieoaiiy i?io?eaeoeee aioo??oiueie?ea?iyieo ?ioaeoe?e oa i?iaeai aeac?ioaeoieia??. - Oa?e?a.- 1997. - N. 60-61. 9. Eoi?aoa A.ss. Canoinoaaiiy eaoa?iia i?e e?eoaaii? aaoeoe //Oac. aeii. 2-ai I?aeia?iaeiiai iaaee/iiai eiia?ano nooaeaio?a ? iieiaeeo a/aieo. - Oa?iii?eue.- 1998. - N. 208-209. 10. Eoi?aoa A.ss. I?eiaiaiea eaoa?iia a eiiieaeniii ea/aiee ?iaeenoiai ainiaeaiey // II Eiia?an o??o?a?a Oe?a?ie. Ca??.iaoe.?ia?o. Ee?a-Aeiiaoeuee.-1998-N.43-45. 11. Eoi?aoa A.ss., E?oaeiia I.A. Eaoa?ii a eiiieaeniiio e?eoaaii? oai?eo ia aaoeoo //Iaoa??aee iaoeiai-i?aeoe/ii? ? iaa/aeueii-iaoiaee/ii? eiioa?aioe?? eaoaae? caaaeueii? o??o?a?? iaaeaoc?a Oe?a?ie III-IV ??ai?a ae?aaeeoaoe??. - Iaeana. - 1998. - N. 59-60. 12. Iieiaeeoaeueiia ?aoaiea ii cayaea ? 96052167 “Niinia ea/aiey ?iaee” io 7.04.98 a. 13. ?aoeeiiaeecaoi?neia i?aaeeiaeaiea ?2724 Oaeinoiaa?aiea ia “Niinia ea/aiey ?iaeenoiai ainiaeaiey eaoa?iiii” auaeaii A?EC Iaeanneiai IaeCI 2.02.98 a. Aiioaoeiy Eoi?aoa A. ss. “Aoaeoeaiinoue eaoa?iia i no?aioiiioiea a eiiieaeniiio eieoaaiii aaoeoe o ii?yeia”. - ?oeiien. Aeena?oaoeiy ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoeiaeueiinoth 14.01.34. - aaiaoeieia, einii/ia oa ii?nueea iaaeeoeeia - AeI “Oe?a?inueeee IAeI ii?nueei? iaaeeoeeie”, Iaeana, 1999. Caoeua?oueny iaoeiaa ?iaioa oa 13 iaoeiaeo ioaeieaoeie. Aeena?oaoeiy i?enay/aia ?ic?iaoe? eiiieaeniiai iaoiaeo eieoaaiiy aaoeoe o ii?yeia i ianaeaiiy i. Iaeane ic canoinoaaiiyi iiaiai iioiiiiiaeoethth/iai i?aia?aoo “Eaoa?ii” - (ethaenueeee ?aeiiaiiaioiee aeueoa-2-a iioa?oa?ii), a oaeiae iinoeaaiai canoinoaaiiy iaci ia aiae?ioieueiie iniiai -”No?aioiiioie”. Eieueeinoue oai?eo aaoeoith neeaaea? 3-4%, ui neeaaea? a na?aaeiueiio 300-400 /ie. ia ?ie. O ii?ye?a oeae iieaciee noaiiaeoue 6 - 8 /ie. ia 1000 oa. Ianoaaeaii 190 oai?eo aaoeoith, a oiio /enei 70 ii?yeia. ?acii ic caaaeueiii?eeiyoeie eeiii/ieie i eaai?aoiieie aiaeicaie i?iaiaeeee aaeoa?iieiai/iee iinia ic aeaeieyth/iai ?aie c iiaeaeueoith iaeaioeoieaoei?th aeaeieaieo noi?iaiaeaeoth/eo iie?ii?aaiiciia i aecia/aiiyi /ooo?ainoi aei ieo aioeaiioeeia. Aeiaaiic aaoeoe anoaiiaethaaany ia iniiai eeiii/ii? ea?oeie caoai?thaaiiy c o?aooaaiiyi aiiaeaiiieiai/ieo aeaieo i ?acoeueoaoia aaeoa?iieiai/iiai ianoaaeaiiy. I?iaiaeeee iioiieiai/ii aeineiaeaeaiiy, aecia/aee /ooo?ainoue iioiioeeoia aei eaoa?iio. Oai?eo ?iciiaeieeee ia 2 a?oie, 100 c yeeo eieoaaeenue caaaeueiii?eeiyoeie caniaaie. Eiio?ieueia a?oia ic 90 oai?eo aeiaeaoeiai io?eioaaea eaoa?ii ii 3 iei II 1 ?ac aioo?ioiueii’yciai ia i?ioyci 5-7 aeiia. Ic oeeo 90 oai?eo - 35-i aeiaeaoeiai cai?iiiiiaaii eieoaaiiy iinoeaai ia iaeanoue ?ai -iacue “No?aioiiioie”. I?e aeineiaeaeaiii o oai?eo aaoeoith iieacaii iiceoeaiee aoaeo iioiii?aaaieioaoeieieo aeie eaoa?iiioa?aii?, yeee iiaeaeuo?oueny i?e canoinoaaiii iaci ia aiae?ioieueiie iniiai -”No?aioiiioie”, ui naiae/eoue i?i aeioeieueiinoue aeaiiai iaoiaeo eieoaaiiy oai?eo aaoeoith. Iniiaii ?acoeueoaoe ?iaioe iiaeooue aooe aeei?enoaii o eieoaaiii oai?eo aaoeoith a oi?o?ai/ieo oa iioaeoeieieo noaoeiiia?ao, a oaeiae a noaeiiaeo aiaoeaoi??yo ii?nueeiai oeioo. Eeth/iai neiaa: aaoeoa, eaoa?ii, iacue “No?aioiiioie”, eiiieaenia eieoaaiiy, iioiioao. Aiiioaoeey Eoi?aoa A. ss. “Yooaeoeaiinoue eaoa?iia e no?aioiieoiea a eiiieaeniii ea/aiee ?iaeenoiai ainiaeaiey o ii?yeia”. ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.34. — aaeaoeeiiiay, einie/aneay e ii?neay iaaeeoeeia. — AI “Oe?aeineee IEE ii?neie iaaeeoeeiu”. a. Iaeanna, 1999. Caueuaaony iao/iay ?aaioa e 13 iao/iuo ioaeeeaoeee. Aeenna?oaoeey iinayuaia ?ac?aaioea eiiieaeniiai iaoiaea ea/aiey ?iaeenoiai ainiaeaiey o ii?yeia e ianaeaiey a. Iaeannu n i?eiaiaieai iiaiai eiioiiiiaeoee?othuaai i?aia?aoa “Eaoa?ii” — (/aeiaa/aneee ?aeiiaeiaioiue aeueoa-2a eioa?oa?ii), a oaeaea ianoiiai i?eiaiaiey iace ia aeae?ioeeueiie iniiaa “No?aioiieoie”. Aeinoeaeaiey a eco/aiee yoeieiaee, iaoiaaiaca, eeeieee e ea/aiey ?iaeenoiai ainiaeaiey niinianoaiaaee i?eiaiaieth iiauo iaoiaeia ea/aiey caaieaaaiey. Oeo/oeeny i?iaiic ?iaee. Iaeiaei eiee/anoai aieueiuo ?iaeae i?iaeieaeaao ninoaaeyoue ii aeaiiui ai?iaeneie eioaeoeeiiiie aieueieoeu a. Iaeannu 3-4% io /enea ainieoaeece?iaaiiuo aieueiuo, /oi ninoaaeyao a n?aaeiai 300-400 /aeiaae a aiae. O ii?yeia yoio iieacaoaeue ?aaiyaony 6 - 8 /ae. ia 1000 aieueiuo. Nouanoaothuea iaoiaeu ea/aiey, oioy e eiatho eeeie/aneee yooaeo, ia iaania/eaatho iieiiai aucaei?iaeaiey e ia ecaaaeytho io aicieeiiaaiey ?aiieo e iicaeieo ?aoeeaeeaia, a oaeaea iiaoi?iuo caaieaaaiee. Yoi iiaeii iauynieoue nieaeaieai a ino?ii ia?eiaea oaeoi?ia eeaoi/iiai e aoii?aeueiiai eiioieoaoa, nio?aiythueiny a ia?eiaea ?aeiiaaeanoeaioeee e aeoeaiinoe ianiaoeeoe/aneeo oaeoi?ia caueou, a oaeaea au?aaeaiiie naineaeeecaoeeae i?aaiecia e iee?iao, yaeythuaiony aicaoaeeoaeai caaieaaaiey. Neaaeiaaoaeueii, aaaeiui a ea/aiee ?iaeenoiai ainiaeaiey yaeyaony ia oieueei i?eiaiaiea aioeaaeoa?eaeueiuo i?aia?aoia, ii e ei??aae?othuae oa?aiee eiioiiaeaoeoeeoiuo ninoiyiee aieueiuo, /oi o?aaoao aeaeueiaeoae aeoeaiie ?ac?aaioee eiiaeie?iaaiiuo iaoiaeia ea/aiey. Ianeaaeiaaii 190 aieueiuo ?iaeae, a oii /enea 70 ii?yeia. Ia?yaeo n iauai?eiyouie eeeie/aneeie e eaai?aoi?iuie aeaiiuie (aiaeec e?iae e ii/e), i?iaiaeeee aaeoa?eieiae/aneee iinaa ec ioaeaeyaiiai ?aiu n iineaaeothuae eaeaioeoeeaoeeae auaeaeaiiuo niioonoaothueo iee?ii?aaieciia e ii?aaeaeaieai /oanoaeoaeueiinoe e iei aioeaeioeeia. Aaeoa?eieiae/aneia enneaaeiaaiea i?iaiaeeee a aeeiaieea: a ia/aea caaieaaaiea aei aioeaeioeeioa?aiee e ia?aae auieneie ec noaoeeiia?a. Aeeaaiic ?iaeenoiai ainiaeaiey noaaeeny ia iniiaaiee eeeie/aneie ea?oeiu caaieaaaiey n o/aoii yieaeaieieiae/aneeo aeaiiuo e ?acoeueoaoia aaeoa?eieiae/aneiai ianeaaeiaaiey. I?iaiaeeee eiioiieiae/aneea iaoiaeu enneaaeiaaiey, ii?aaeaeyee /oanoaeoaeueiinoue eiioiioeeoia e eaoa?iio. Aieueiua auee ?ani?aaeaeaiu ia 2 a?oiiu, ec eioi?uo 100 iaoeeaioia ea/eeenue iauai?eiyouie n?aaenoaaie. Eiio?ieueiay a?oiia ec 90 aieueiuo aeiiieieoaeueii e i?iaiaeeiiio ea/aieth iieo/aea eaoa?ii ii 3 iei IA 1 ?ac aioo?eiuoa/ii a oa/aiea 5-7 aeiae. Ec yoeo 90 aieueiuo — 35 aeiiieieoaeueii e i?eiyoiio ea/aieth ianoii ia iaeanoue ?ai i?eiaiyee iacue “No?aioiieoie”. A eeeieeo aiaae?aiu iiaua iaoiaeu eiiieaeniiai ea/aiey aieueiuo ?iaeenoui ainiaeaieai n eniieueciaaieai eeeie/aneeo e eiioiieiae/aneeo iaoiaeia enneaaeiaaiey, iieacaia yooaeoeaiinoue eaoa?iiioa?aiee. I?e enneaaeiaaiee o aieueiuo ?iaeae ioia/aaony ei??aeoeey eiioiiiaoieiae/aneeo naeaeaia (aeoeaaoeey O-oaeia?iie e O-noi?anna?iie aeoeaiinoe, oaaioeeoica, ii?iaeecaoeee o?iaiy eiioiiaeiaoeeiia) e ia?ooaiiiai ianoiiai eiioieoaoa, /oi i?iyaeyaony a iiauoaiee niaea?aeaiey nae?aoi?iiai eiioiiaeiaoeeia A a nuai?ioea e?iae. Iieacai iieiaeeoaeueiue yooaeo eiioii?aaaeeeoaoeeiiiuo aicaeaenoaee eaoa?iiioa?aiee, eioi?ue iiauoaaony i?e i?eiaiaiee iace ia aeae?ioeeueiie iniiaa “No?aioiieoie”, /oi naeaeaoaeuenoaoao i oeaeaniia?aciinoe i?eiaiaiey aeaiiiai iaoiaea ea/aiey o aieueiuo ?iaeenoui ainiaeaieai. Iniiaiua ?acoeueoaou ?aaiou iiaoo auoue eniieueciaaiu a ea/aiee aieueiuo ?iaeae a oe?o?ae/aneeo e eioaeoeeiiiuo noaoeeiia?ao. Eeth/aaua neiaa: ?iaeenoia ainiaeaiea, eaoa?ii, iacue “No?aioiieoie”, eiiieaeniia ea/aiea, eiioieoao. Summary Kuprata V.Ya. Efficacy of lapheron and streptonin use in complex treatment of erysipelas in seafarers. - Manuscript.- The thesis for the competition of a candidate’s degree in medicine.- Speciality - 14.01/34 - aircraft, space and maritime medicine. State Enterprise “Ukrainian Research Institute of Maritime Medicine”. - Odessa, 1999. A research study and 13 learned works are defended. The thesis is devoted to the development of erysipelas method complex treatvent in seafarers and population of Odessa with the use of a new immunjmodulative remedy lapheron, a human recombinant a-2b interferon, and local use of an oinment with hydrophilic base streptonitol. The morbidity rate of erysipelas is 300 - 400 persons per year among munical population and 6 - 8 persons for 1000 among seafarers. 190 erysipelas patients among them 70 seafarers had been examined. Together with common clinical and laboratory tests they did inoculation from a wound?s discharge and identification of the microorganisms eliminated and their sensitivy to antibiotics. Erysipelas had been diagnosed on the base of clinical characterictics, epidemiological data and results of bacteriological observation. Immunological investigations had been done and immunocytes sensitivity to lapheron determined. The patients had been divided into two groups, 100 of them got commonly used remedies. Control group included 90 patients who additionally received lapheron by 3 mln IU once per day intramuscular during 5 - 7 days. 35 of them got local treament of the wounds with streptonitol. They had revealed a positive influence and immunorehabilitative action of therapy with lapheron with lapheron which increases under the combined use of hydrophilic oinment, e.g. streptonitol. The data obtained prove about advantage of the method worked out the treatment of erysipelas patients. The main results of the research may be used in surgical and infections in - patient units as well as in ship ambulatories. Key words: erypelas, lapheron, oinment “Streptonitol”, complex treatment, immunity.

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