Диференційована інтенсивна респіраторна терапія та її вплив на антиінфекційний захист органів дихання у хворих з бронхоастматичним статусом (клінічне

Aei?i?iiao?ianueea aea?aeaaia iaaee/ia

aeaaeai?y

Naoeooa Na?a?e Aaneeueiae/

OAeE 615:612.017.1+616.248-084-056.24

Aeeoa?aioe?eiaaia ?ioaineaia ?ani??aoi?ia oa?ai?y oa ?? aieea ia
aioe?ioaeoe?eiee caoeno i?aai?a aeeoaiiy o oai?eo c a?iioianoiaoe/iei
noaoonii

(ee?i?/ia aeine?aeaeaiiy)

14.01.30 — Aianoac?ieia?y oa ?ioaineaia oa?ai?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Aei?i?iiao?ianuee, 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? NI?OeEI Ieaa Ieeieaeiae/, Eoaainueeee
aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee eaoaae?ith
aeno?aiaeueii? oa a?enueeiai? iaaeeoeeie c aianoac?ieia??th.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Ni?na?ue Aieiaeeie? ?aaiiae/, i?ioani?
eaoaae?e aianoac?ieia?? oa ?aai?iaoieia?? Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai??

aeieoi? iaaee/ieo iaoe, i?ioani? EO?AIIA ?aaai Iao?iae/, caa?aeoth/ee

eaoaae?ith aianoac?ieia?? oa ?ioaineaii? oa?ai?? Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo

I?ia?aeia onoaiiaa:

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, eaoaae?a iaaeeoeeie
iaa?aeeeaaeieo noai?a oa aianoac?ieia??, IIC Oe?a?ie, i. Oa?e?a.

Caoeno a?aeaoaeaoueny » _30__ » _ea?oiy_ 1999 ?. i _13_ aiae. a aoae.
?_9_ ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 08.601.01 o
Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai?? (320044, i.
Aei?i?iiao?ianuee, aoe. Aeca?aeeinueeiai, 9).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (322044, i. Aei?i?iiao?ianuee, aoe.
Aeca?aeeinueeiai, 9).

Aaoi?aoa?ao ?ic?neaiee » _27_ » _aa?aciy_ 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii?

?aaee, aeioeaio A.I.Oea/aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie.

Oeueiai /ano a?iio?aeueia anoia (AA) yaey? niaith iaeio c oeaio?aeueieo
i?iaeai aioo??oiuei? iaaeeoeeie, ye?e i?eae?eythoue aaeeeo oaaao ?
oai?aoeee, ? ee?i?oeenoe- oa?aiaaoe, ioeueiiiieiae, ?aai?iaoieiae ?
iaa?oue o??o?ae. Iiynith?oueny oea oei, ui a inoaii? ?iee AA
ia?aoai?eeanue o iioe?aia caoai?thaaiiy, ui o?aaea? aieiaiei /eiii
iieiaeee, iaea?eueo i?aoeacaeaoiee eiioeiaaio ianaeaiiy; ca?eueoo?oueny
e?euee?noue oyaeeeo oi?i AA, ?inoa eaoaeuei?noue (A.I.Neaei?aiei, 1991).

Iaea?eueo oyaeeei ? iaaacia/iei aeey aeeooy oneeaaeiaiiyi AA ?
a?iioianoiaoe/iee noaoon (AAN). Aeey eiai onoiaiiy oe?iei
canoiniaothoueny ??ciiia-i?oi? iaoiaee ?ioaineaii? ?ani??aoi?ii? ?
iaaeeeaiaioicii? oa?ai??. I?ioa ca aeiiiiiaith oeeo iaoiae?a e?eoaaiiy
ia caaaeaee aaea?oueny onoiooe ?icaeoie caiaeueieo i?ioean?a a i?aaiao
aeeoaiiy, a?aeiiaeoe a?iio?aeueio i?io?aei?noue ? ciai?oi? aeeoaiiy,
aeaanoe oai?iai ?c e?eoe/iiai noaio. A?eueo oiai, /ano? ia’?ii? eaaaae?
o?aoaia?iio?aeueiiai aea?aaa (OAAe), ooo/ia aaioeeyoe?y eaaai?a (OAE) ?
o?aoainoii?y nai? iiaeooue ni?eyoe ?icaeoeo oa i?aeo?eioe?
caiaeueii-iaai?eieo oneeaaeiaiue c aieo i?aai?a aeeoaiiy, aaia?ae?caoe??
?ioaeoe?? ? naioe/ieo noai?a (A.?.O?a-ueinueeee c ni?aaao., 1985).

Aeani? niinoa?aaeaiiy ? ia/eneaii? aeai? e?oa?aoo?e aeicaieeee iai
aeneiaeoe i?eiouaiiy, ui iaaeinoaoiy aoaeoeai?noue ?nioth/eo iaoiae?a
?i-oaineaii? ?ani??aoi?ii? oa?ai?? (??O) ? aenieee i?ioeaio oneeaaeiaiue
aiane?aeie ?o canoinoaaiiy o oai?eo c AAN iica’ycai? c oei, ui i?e oe?e
iaoieia?? ia iiai?noth a?aoiaothoueny ii?ooaiiy o iaoai?ciao
naiii/euaiiy a?iio?a ? noai ?ioi?oaoo aeeoaeueii? nenoaie (?AeN).

Iiaeeaeaia aea/aiiy ? aiae?c ii?ooaiue a ?AeN, a oaeiae ?ic?iaea niiniao
??O, yeee ae ni?eya a?eueo aoaeoeaiiio ?o onoiaiith, aeicaieyoue
iie?aueoe ?acoeueoaoe e?eoaaiiy oeeo oai?eo ? a cia/i?e i???
iioei?coaaoe i?iaiic i?e AAN. Iniaeeai? cia/eiino? iaaoaa? ?ica’ycaiiy
oeeo caaea/ aeey i?aeoe/ii? ioi?iie caei?ia’y, eiee a?eueo ae?aaeaiee
ee?i?/iee aoaeo aeinyaa?oueny aac caeo/aiiy aeiaeaoeiaeo cania?a ?
??aee?niiai aei?iaiai iniauaiiy (uiaei aa?oino?).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?y ? o?aaiaioii eiiieaenii? oaie eaoaae?e aeno?aiaeueii? oa
a?enueeiai? iaaeeoeeie c aianoac?ieia??th EAeIO «?ic?iaea ?aa?iia?ieo
iaoiae?a aeaoieneeaoe?? i?e e?eoe/ieo noaiao, iaoiiaeaieo
?ioaeoe?eii-caiaeueieie oneeaaeiaiiyie caieo i?aai?a aeeoaiiy oa
/a?aaii? ii?iaeieie», ? aea?ae?a?no?aoe?? 01950070035, oeo? ?I-9.95.

Iaoa ? caaea/? aeine?aeaeaiiy.

I?aeaeueoe aoaeoeai?noue iaoiae?a ?ioaineaii? ?ani??aoi?ii? oa?ai?? o
oai-?eo c a?iioianoiaoe/iei noaoonii, oeyoii aeeoa?aioe?eiaaiiai ?o
canoinoaai-iy, c a?aooaaiiyi ae?aciino? aino?i? aeeoaeueii?
iaaeinoaoiino?, noaio aioe?i-oaeoe?eiiai caoenoo ? ?ioiii? ?aaeoeaiino?
i?aai?a aeeoaiiy.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/?:

1. O oai?eo c AAN, a caeaaeiino? a?ae noaae?? aino?i? aeeoaeueii?
iaaeinoaoiino? (AAeI), aea/eoe aiaeineii?/io ea?oeio neeciai? iaieiiee
o?aoaia?ii-o?aeueiiai aea?aaa, ioe?ieoe oeeoieia?/i? ? aaeoa??ieia?/i?
iieacieee a?iio?-aeueiiai nae?aoo.

2. Aeine?aeeoe ianiaoeeo?/i? ? niaoeeo?/i? iieacieee i?noeaaiai caoenoo
i?aai?a aeeoaiiy: ooieoe?eiee noai a?yeueiiai ai?oae?th ca ?iaeaenii
eiai aeaaaia?aoe??; oaaioeeoa?io ? aaeoa?eoeeaeio aeoeai?noue
aeueaaiey?ieo iae?ioaa?a; iieacieee ?I, caaaeueiiai a?eea, n?aeiaeo
eeneio ? oa?iaioo io?ai?aeace o a?iio?aeueiiio nae?ao?; eiioeaio?aoe?th
o iueiio ?ioiiaeiaoe?i?a eean?a A, G ? M.

3. Anoaiiaeoe o aeaieo oai?eo caeaaei?noue i?ae ci?iaie a ?AeN ?
nooiaiai ae?aciino? AAeI.

4. Aeine?aeeoe aieea o?aaeeoe?eii? ??O ia ooieoe?eiee noai
a?iioieaaaiaai? nenoaie ?, a ia?oo /a?ao, ia ianiaoeeo?/i? ? niaoeeo?/i?
iaoai?cie i?noeaaiai caoenoo i?aai?a aeeoaiiy.

5. Ia iniia? io?eiaieo ?acoeueoao?a ?ic?iaeoe niin?a aeeoa?aioe?eiaaii?
??O, aea/eoe aieea ?? iaoiae?a ia ?AeN ? aecia/eoe ?o aoaeoeai?noue o
caaaeueiiio eiiieaen? caoiae?a ?ioaineaii? oa?ai?? i?e AAN.

6. Cieceoe caaaeueio eaoaeuei?noue o oai?eo c AAN.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa ia iniia? eiiieaeniiai aeine?aeaeaiiy aiaeineii?/ieo,
oeeoieia?/ieo, aaeoa??ieia?/ieo, a?io?i?/ieo ? ?ioiieia?/ieo iieaciee?a
a?iioieaaaiaai? nenoaie anoaiiaeaii, ui ?nioth/? iaoiaee ??O nooo?ai ia
aieeaathoue ia ii?ooaiee ?AeN o oai?eo c AAN. Iieacaii, ui OAE ? /ano?
ia’?ii? eaaaae? OAAe iaaaoeaii aieeaathoue ia aoii?aeuei? oaeoi?e ?AeN.
Anoaiiaeaii, ui i?e AAN ? caeaaei?noue i?ae aeeaeiith iioeiaeaeaiue o
i?noeaaiio aioe?ioaeoe?eiiio caoeno? ? nooiaiai ae?aciino? AAeI.
Iiaeaeueoee ?icaeoie io?eiaea eiioeaioe?y aeeoa?aioe?eiiai canoinoaaiiy
iaoiae?a ??O o caeaaeiino? a?ae aeaeo aiaeia?iio?oo ? nooiaiy ii?ooaiue
a ?AeN. Oaeineiiaeaii oaoiieia?th e?eoaaiiy oai?eo c AAN.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

A ee?i?/io i?aeoeeo ai?iaaaeaeaiee niin?a aeeoa?aioe?eii? ??O i?e AAN,
yeee a?eueo aoaeoeaii ni?ey? a?aeiiaeaiith ooieoe?? ciai?oiueiai
aeeoaiiy ? ii?ooaieo iieaciee?a ?AeN, a oaeiae ciaioo? iaaaoeaiee aieea
iaoiae?a ??O ia aioe?ioaeoe?eiee caoeno i?aai?a aeeoaiiy. Oea ni?ey?,
aac canoinoaaiiy ??aee?nieo ? aei?iaieioooth/eo iaaeeeaiaio?a ?
aia?aoo?e, ciaioaiith e?eueeino? ?ioaeoe?eii-caiaeueieo oneeaaeiaiue,
i?aeaeuaiith aoaeoeaiino? e?eoaaiiy ? cieaeaiith eaoaeueiino? i?e AAN ia
6,25%. Niin?a aeeoa?aioe?eii? ??O ia? aaeeea i?aeoe/ia cia/aiiy ?
ai?iaaaeaeaiee o e?eoaaeueiee i?ioean eo?no aianoac?ieia?? ? ?ioaineaii?
oa?ai?? E?einueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
?i.N.?.Aai?a??anueeiai (aeo ai?iaaaeaeaiiy a?ae 04.05.1998 ?.),
Eoaainueeiai i?nueeiai oeaio?o ?ioaineaii? oa?ai?? ? ?aai?iaoe?? (aeo
ai?iaaaeaeaiiy a?ae 15.10.1998 ?.).

Iaoa??aee aeena?oaoe?? aeei?enoiaothoueny o iaa/aeueiiio i?ioean? aeey
nooaeaio?a, e?ea??a-?ioa?i?a ? e?ea??a-eo?naio?a ia eaoaae?ao
aianoac?ieia?? ? ?aai?iaoieia?? E?einueeiai ? Eoaainueeiai aea?aeaaieo
iaaee/ieo oi?aa?neoao?a.

Iniaenoee aianie caeiaoaa/a.

Aaoi?ii naiinoieii i?iaiaeiciaaia eioa?aoo?a ca ia?aiith i?iaeaiith,
i?iaaaeaiee aeeaieee iioi?iaoeieiee iiooe. ?acii c iaoeiaei ea?iaieeii
aeieoi?ii iaae.iaoe, i?io.Niioeeiei I.I. aecia/aii iaoa i caaea/i
aeineiaeaeaiue, iaaiai?aii i noi?ioeueiaaii iniiaii iieiaeaiiy aeaa
aeanieo aeineiaeaeaiue, aeniiaee, i?aeoe/ii ?aeiiaiaeaoei?. Aaoi?ii
aea/aiee aieea iaoiaeia I?O ia a?iioieaaaiaao nenoaio. Aeineiaeaeaiiy
nenoaie iinoeaaiai iioiioaoo i?aaiia aeeoaiiy aeeiiaii o
eeiiiei-iioiieiai/iie eaai?aoi?i? Eoaainueeiai aea?aeaaiiai iaaee/iiai
oiiaa?neoaoo ?acii c caa. eaai?aoi?i?th Naa?i N.I. Aaoi?ii
aaeineiiaeaiee i ai?iaaaeaeaiee o i?aeoeeo iaoiae aeeoa?aioeieiaaii?
I?O. O eeiii/iiio ianoaaeaiii i eieoaaiii anio iaoei?ioia aaoi? a?aa
aaciina?aaeith o/anoue. O niieueieo ae?oeiaaieo ?iaioao aaoi?o
iaeaaeeoue 85% iaeae i ?ic?iaie.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

Iaoa?iaee aeena?oaoei? aeeeaaeaii ia 2 Iiaeia?iaeiiio eiia?ani iieiaeeo
a/aieo o i.Oa?iiiiei, 1998 ?., ia XIV Iaoeiiiaeueiiio c’?caei oa?aiaaoia
o i.Ee?ai, 1998, ia 2 Eiia?ani c iiaeia?iaeiith o/anoth «Iaeeeaoeaiay
iaaeeoeeia e ?aaaeeeoaoeey a cae?aaiio?aiaiee», i.Iineaa, 1998 ?., ia
eiioa?aioei?, i?enay/aiie 25-?i//th eaoaae?e aianoaciieiai? i
?aaiiiaoieiai? Aeiii?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeaii?,
i.Aeiii?iiao?ianuee, 1998.

Ioae?eaoe??.

Ca oaiith aeena?oaoei? aaoi? iioaeieoaaa 11 iaoeiaeo i?aoeue, c ieo 5 o
oaoiaeo aeaeaiiyo (1 noaooy o aeo?iaei «Oe?a?inueeee iaaee/iee
aeueiaiao», 4 noaooi o aeo?iaei «Ainiee i?iaeai aiieiai? i iaaeeoeeie»),
6 iioaeieiaaii o oi?ii oac aeiiiaiaeae ia eiioa?aioeiyo i eiia?anao.

Ianya oa no?oeoo?a aeena?oaoe??.

Aeena?oaoeiy aeeeaaeaia ia 149 noi?iieao iaoeiiieniiai oaenoo,
iethno?iaaia 37 oaaeeoeyie i 4 iaethieaie, yei caeiathoue 11 noi?iiie.
Neeaaea?oueny ic anooio, 4 ?icaeieia (iaeyae eioa?aoo?e, iaoa?iaeia i
iaoiaeia aeineiaeaeaiue, 2 ?icae?e?a aeanieo aeine?aeaeaiue), aiaeico i
ocaaaeueiaiiy ?acoeueoaoia aeineiaeaeaiiy, aeniiaeia, i?aeoe/ieo
?aeiiaiaeaoeie i iieaae/eea eioa?aoo?e, yeee ia? 201 aeaea?aei, c yeeo
108 ee?eeeoeath i 93 eaoeieoeath.

Iniiaia /anoeia

Iaoa??aee ? iaoiaee aeine?aeaeaiiy.

A iniiao ?iaioe iieeaaeai? aeai? ee?i?/iiai niinoa?aaeaiiy, ianoaaeaiiy
? e?eoaaiiy 120 oai?eo c AAN, yeee ?icaeioany ia oii?
?ioaeoe?eii-caeaaeii? AA. In?a /ieia?/i? noao? aoei 52 (43,3%), ae?ii/i?
-68 (56,7%). Iaea?eueoee i?ioeaio (73,33%) iaoe??io?a neeaaeaee iniae
iieiaeiai ? i?aoeacaeaoiiai a?eo a?ae 21 aei 50 ?ie?a.

Aeey aecia/aiiy nooiaiy aaaeeino? caoai?thaaiiy aeei?enoaia
eeaneo?eaoe?y anoiaoe/iiai noaio AIAe? ioeueiiiieia?? o iiaeeo?eaoe??
A.?.O?aueinueeiai c ni?aaao. (1985), yea ia?aaeaa/a? 3 noaae?? AAN: I
noaae?y – a?aeiinii? eiiiainaoe?? AAeI; II noaae?y — aeaeiiiainaoe??
AAeI; III noaae?y – a?iienai?/ii? eiie.

On? ianoaaeai? oai??, c a?aooaaiiyi canoiniaaii? iaoiaeeee ??O ?
a?aeiia?aeii aei aeacaii? eeaneo?eaoe??, aoee iiae?eai? ia 2 a?oie ii 60
/ieia?e.

I a?oia: 20 oai?eo o noaae?? a?aeiinii? eiiiainaoe?? ? 40 oai?eo o
noaae?? aeaeiiiainaoe?? AAeI. O oe?e a?oi? canoiniaoaaany o?aaeeoe?eiee
i?aeo?ae aei ??O AAN.

II a?oia: 28 oai?eo o noaae?? a?aeiinii? eiiiainaoe?? AAeI ? 32
iaoe??ioa o noaae?? aeaeiiiainaoe??. O oe?e a?oi? oai?eo
canoiniaoaaeanue aeeoa?aioe?eiaaia ??O.

Aeey eiiieaenii? ioe?iee noaio a?iioieaaaiaai? nenoaie o an?o oai?eo
ii?yae c caaaeueiiee?i?/iith ? eaai?aoi?iith ae?aaiinoeeith
canoiniaoaaeenue ooieoe?ei?, ?aioaaiieia?/i? ? ?ioiieia?/i? iaoiaee
aeine?aeaeaiue.

Aeey aea/aiiy ooieoe?eiiai noaio i?aai?a aeeoaiiy caeo/aeanue
aiethiao??y, aeine?aeaeoaaeenue iieacieee eeneioii-iniiaiiai noaio ?
aaciaiai neeaaeo e?ia?.

?aioaaiieia?/i? iaoiaee aeeth/aee ?aioaaiia?ao?th i?aai?a aeeoaiiy.

Aiaeineii?/i? iaoiaee iieyaaee o aea/aii? noaio neeciai? iaieiiee OAAe ?
eiai i?io?aeiino? ca aeiiiiiaith ?ea?aeiiai a?iioineiio O?eaeaey c
?iaeaeoe?eiith OAE ? o?a?ia?iioineiia o??ie «Ie?iion». A?iioineii?/ia
ioe?iea caiaeueieo ci?i a?iio?a i?iaiaeeeanue ca eeaneo?eaoe??th
A.A.Aa?an?ia (1981).

I?e a?io?i?/iiio aeine?aeaeaii? aea/aany ?I o?aoaia?iio?aeueiiai nae?aoo
(ca aeiiiiiaith a?o/eciyiiai ?I-iao?a), ci?no o iueiio caaaeueiiai a?eea
(a?o?aoiaei iaoiaeii) ? n?aeiaeo eeneio (iaoiae Aanna).

Oeeoieia?/i? iaoiaee aeine?aeaeaiiy ia?aaeaa/aee e?euee?nia aea/aiiy
ee?oeiiiai neeaaeo o o?aoa? ? a?iioao ca aeiiiiiaith iace?a-a?aeoene?a,
niiia-a?iin?? ? ae?aaiinoe/iiai a?iioiaeueaaiey?iiai eaaaaeo.

Ianiaoeeo?/i? iaoai?cie i?noeaaiai caoenoo i?aai?a aeeoaiiy aea/aeenue
ca ?iaeaenii aeaaaia?aoe?? a?yeueiiai ai?oae?th (?AeAA) ca iaoiaeii
A.ss.In?i?ia ? E.A.Iaoa??ai? (1978) ? ca ooieoe?eiith aeoeai?noth
aeueaaiey?ieo iae?ioaa?a (AI). I?i oaaioeeoa?io aeoeai?noue AI
ae?ciaaaeenue ca ?o aeeoo?caeaoi?noth, oaaioeeoa?iiio /eneo (O*) ?
oaaioeeoa?iiio ?iaeaeno (O?) ca iaoiaeii A.A.Aa?an?ia c ni?aaao.(1980).
Aaeoa?eoeeaeio aeoeai?noue AI ioe?ithaaee ca ?o caeaoi?noth
a?aeiiaethaaoe i?o?inei?e oao?acie?e (INO-oano) ca iaoiaeeeith
Ae.I.Iayinueeiai c ni?aaao. (1986).

Niaoeeo?/i? iaoai?cie i?noeaaiai caoenoo i?aai?a aeeoaiiy aea/aeenue ca
ai?noii o a?iio?aeueiiio nae?ao? aioeaaeoa??aeueiiai oa?iaioo
io?ai?aeace (iaoiaeii ?.O.*a?iooaiei ? A.N.Eiainiai? (1981),
?ioiiaeiaoe?i?a eean?a A, G ? M iaoiaeii ?ioiiaeeooc?? ca Iai/?i? — ca
iaoiaeeeith I.?.Ei?ieue ? A.I.Iieiaeoeiai? (1981).

Aeine?aeaeaiiy aeeiioaaeenue i?e anooi? oai?eo (1-2 aeiaa), ia 5-7 aeiao
e?eoaaiiy ? i?ney eiai cae?i/aiiy (12-15 aeiaa).

Io?eiai? aeai? ii??aithaaeenue c aeaieie eiio?ieueii? a?oie (20 /ie. aac
a?iioieaaaiaai? iaoieia??).

Iaoaiaoe/iee aiae?c io?eiaieo ?acoeueoao?a i?iaiaeeany ia ia?niiaeuei?e
AII ?AI ?N AO c canoinoaaiiyi i?ia?aie MS «Excel-95», aeinoia??i?noue
ioe?ithaaeanue ca e?eoa???i Nouethaeaioa. Aeinoia??ieie aaaaeaeenue
iieacieee i?e ?<0,05. ?acoeueoaoe aeanieo aeine?aeaeaiue. Aiae?c ?acoeueoao?a aiaeineii?/ieo aeine?aeaeaiue, i?iaaaeaieo o oai?eo iaio a?oi ia 1 aoai?, iieacaa, ui o 1 noaae?? AAN o 80% iaoe??io?a AAeI i?io?eaea ia oii? eaoa?aeueiiai aiaeia?iio?oo, a o 20% - ia oii? ai?eiiai. O 2 noaae?? AAN eaoa?aeueiee aiaeia?iio?o aoa ae?aaiinoiaaiee o 40% niinoa?aaeaiue, ai?eiee aiaeia?iio?o o 60%. Ni?aa?aeiioaiiy aen?yii? c OAAe i?e?ioei?e a iaio noaae?yo aoei i?eaeecii iaeiaeiaei ? iaei oaeee aeaeyae: no?aioieie - 30,1%, iaenna??? - 23%, noao?eieie - 18,7%, nei?ai?eia iaee/ea - 8,7%, ee?an??ee - 7,8%, ae??ae/? - 3,8%, eeoa/ia iaee/ea - 3,2%, i?ioae - 1,8%, iiaaiieiee - 0,9%. Aeai? aeine?aeaeaiiy ianiaoeeo?/ieo ? niaoeeo?/ieo iieaciee?a i?noeaaiai caoenoo i?aai?a aeeoaiiy o oai?eo 1 ? 2 a?oi ia 1 aoai? niinoa?aaeaiue na?ae/eee i?i iayai?noue ae?aaeaieo ii?ooaiue o eiai iniiaieo eaieao (oaae.1). Oaaeeoey 1 Iieacieee iinoeaaiai caoenoo i?aaiia aeeoaiiy ia ia?oiio aoaii aeineiaeaeaiue IieacieeEiio?ieue1 noaaeiy AAN2 noaaeiy AAN?I7,2±0,27,7±0,2*7,9±0,2**Aieie, a/e0,7±0,110,9±0,8*13,8±2,3**Niaeiai eeneioe, oi.iae.24,4±4,5101,4±12,1*125±11**I?iaeiaaeaiiy oaae. 1Io?aiiaeaca, a/e6,3±1,22,6±0,9*1,3±0,3**IAeAA0,23±0,040,31±0,06*0,39±0,01**AEeoo?caea oiinoue AI, %88,3±2,254,3±4,5*37,9±3,4**Oaaioeeoa?ia /enei (O*), %47,5±2,731,2±6,7*17,7±5,4**Oaaioeeoa?iee iiaeaen (OI)7,3±1,35,3±1,3*2,5±1,3**n-INO-oano, %11,1±1,930,6±3,4*41,1±4,1**n-INO-oano (NOeE)0,64±0,040,70±0,05*0,76±0,06**S?gA0,22±0,020,15±0,04*0,08±0,03**Ig G0,14±0,030,23±0,02*0,13±0,04**IgM--0,01±0,02**I?eiioea: iaeia ci?i/ea - aiaeiiiiinoi aeinoiai?ii o ii?iaiyiii c eiio?ieai (i?e ?<0,001), aeai ci?i/ee - oa ae o ii?iaiyiii iiae a?oiaie. C oaae.1, aa/eii, ui ii?ooaiiy a aioe?ioaeoe?eiiio caoeno? iineee ??ciiiai?aaeaiee oa?aeoa? ? caeaaeaee a?ae noaae?? AAN ? aeaeo aiaeia?iio?oo. Oae, o ii??aiyii? c eiio?ieueieie iieacieeaie, a 1 ? 2 noaae?yo AAeI a?aecia/aeinue ca?eueoaiiy ?I a?iio?aeueiiai nae?aoo. I?e oeueiio aoei iii?/aii, ui /ei ae?aaeai?oei aoa nooi?iue caiaeueieo ci?i o OAAe, oei a?eueo eoaeiith aoea ?I a?iio?aeueiiai nae?aoo. O niinoa?aaeaiiyo, aea oeae iieaciee a?aeiia?aeaa eoaei?e aai neaaeieoaei?e ?aaeoe?? (?I 7,4-7,7 ? a?eueoa) aen?aaeinue iaea?eueoa e?euee?noue eoeueoo? iaoiaaiieo i?e?ii?aai?ci?a. Iai?ioe, iaeo?aeueia aai neaaeieenea na?aaeiaeua (?I 7,2-6,9) aoei iani?eyoeeaith oiiaith aeey ?o ?icaeoeo. Eiioeaio?aoe?y io?ai?aeace a 1 noaae?? cieaeoaaeanue o 2,4 ?ace, a o 2 - i?aeoe/ii o 5 ?ac?a. Aeyaeai? ii?ooaiiy ooieoe?eii? aeoeaiino? AI oa?aeoa?ecoaaeenue cieaeaiiyi oaiiiaio ?o aaeaac?? aei neea, ciaioaiiyi e?eueeino? ee?oei, ye? a?aee o/anoue o oaaioeeoic? o ?yae? niinoa?aaeaiue aei 19-20%, ? cieaeaiiyi ?o oaaioeeoa?ii? aeoeaiino? ii a?aeiioaiith aei /anoeiie eaoaeno. Caa?oaei ia naaa oaaao ca?eueoaiiy e?eueeino? INO-iiceoeaieo AI ? na?aaeiueiai oeeoio?i?/iiai eiao?oe??ioo (NOeE). Aiaeii/an, nooi?iue ?o oao?acie??ai? aeoeaiino? aoa iecueeei ?, ye i?aaeei, a 1 noaae?? ia ia?aaeuoaaa 2 nooi?iue, a o ae?oa?e noaae?? - 1 nooi?iue. I?i?iaeueia ooieoe?eia aeoeai?noue AI aeyaeyeanue o oai?eo c ai?eiei aiaeia?iio?oii i?e iaeneiaeueii ae?aaeaieo yaeuao a?iioiiaoo?aoe??. Iaaiaee, aenie? iieacieee ooieoe?eii? aeoeaiino? AI aeyaeyeenue o iaoe??io?a c eaoa?aeueiei aiaeia?iio?oii. Aoii?aeuei? oaeoi?e ?ioiiiai caoenoo i?aai?a aeeoaiiy o oai?eo a 1 noaae?? AAN ciaoiaeeeenue o noai? a?aeiinii? aai ae?aaeaii? iai?oae - niinoa??aaeinue aeinoia??ia i?aeaeuaiiy eiioeaio?aoe?? IgG ? cieaeaiiy SIgA, aieiaiei /eiii o iaoe??io?a c ai?eiei aiaeia?iio?oii. O 2 noaae?? niinoa??aaeinue iiaeaeueoa cieaeaiiy SIgA ? cieaeaiiy IgG. E??i oiai, o 2 noaae?? aoea iii?/aia aeinoia??ia iiyaa o a?iio?aeueiiio nae?ao? IgM, ui aoei iciaeith aeaeiiiainaoe?? o ?AeN. Oaeei /eiii, aiae?c ?acoeueoao?a aeine?aeaeaiue iieacaa, ui /ei cia/i?oeie aoee ii?ooaiiy o iieacieeao, ui oa?aeoa?ecothoue noai ianiaoeeo?/ieo ? niaoeeo?/ieo iaoai?ci?a i?noeaaiai caoenoo i?aai?a aeeoaiiy, oei a?eueoa ae?aaeaieie aoee a ieo caiaeuei? ? iano?oeoeai? yaeua, oei cia/i?oei aoa nooi?iue ae?aciino? AAN. Io?eiai? aeai? aeaee i?aenoaae aeey ?ic?iaee oa aea/aiiy aieeao ia ?AeN iaoiaeo aeeoa?aioe?eiaaii? ??O. Aoaeoaaeanue aiia c o?aooaaiiyi noaae?? AAeI, aeaeo aiaeia?iio?oo ? nooiaiy ae?aciino? ii?ooaiue a aioe?ioaeoe?eiiio caoeno? i?aai?a aeeoaiiy. ?? iniiai? i?eioeeie iieyaaee a oaeiio. O oai?eo II a?oie, aea aoea ae?aaiinoeeiaaia 1 noaae?y AAN c yaeuaie eaoa?aeueiiai aiaeia?iio?oo c? neeciaith a?ia?nae?aoe??th, naiaoe?y OAAe i?iaiaeeeanue a oiiaao o?a?ia?iioineii?? c ?ioa?aaeii 7-8 aei?a ? ?iaaeyoe?eii? oa?ai??. I?e eaoa?aeueiiio aiaeia?iio?o? c? neeciai-ai?eiith a?ia?nae?aoe??th ?ioa?aae i?ae a?iioineii?yie nei?i/oaaany aei 5-6 aei?a. A?iioineii?/i? naiaoe?? aeiiiaithaaeenue uiaeaiieie ?iaaeyoe?yie ? o?aino?aoaaeueieie ?inoeeyoe?yie. I?e ai?eiiio aiaeia?iio?o? naiaoe?y OAAe i?iaiaeeeanue ca aeiiiiiaith ?ea?aeiiai a?iioineiio c ?iaeaeoe?eiith OAE c ?ioa?aaeii 4-5 aei?a ? o?aino?aoaaeueieo ?inoeeyoe?e. O 2 noaae?? AAN i?e eaoa?aeueiiio aiaeia?iio?o? c? neeciai-ai?eiith a?ia?nae?aoe??th naiaoe?th OAAe i?iaiaeeee o?eueee a oiiaao ?ea?aeii? a?iioineii?? c OAE c ?ioa?aaeii 5-6 aei?a. I?e ae?aaeai?e aeaeiiiainaoe?? o aaciiai?i? ? iayaiino? ai?eiiai aiaeia?iio?oo naiaoe?y i?iaiaeeeanue /a?ac ?iooaaoe?eio o?oaeo ia oii? aeiiii?aeii? aai OAE. Iieacaiiyie ia?aaaaeaiiy oai?eo ia OAE aoee ?aNI2 aeua 7,98 eIa ? ?aI2 ieae/a 7,89 eIa. I?ney onoiaiiy aeaeiiiainaoe?? o aaciiai?i? (?aNI2 5,78 eIa, ?aI2 8 eIa c FiO2 ieae/a 0,4) a eiiieaen e?eoaaeueieo caoiae?a aeeth/aee a?iioineii?? c ?ioa?aaeii 4 aei? ? o?aino?aoaaeuei? ?inoeeyoe??. Aeey onoiaiiy ii?ooaiue o a?io?i?/ieo, oeeoieia?/ieo ? ?ioiieia?/ieo iieacieeao a?iio?aeueiiai nae?aoo aaaeeeaiai cia/aiiy iaaeaaaee i?aaeeueiiio i?aeai?o ? niiniao aaaaeaiiy i?noeaaiae?th/eo e?ea?nueeeo i?aia?ao?a, ye? iiaeii? a?aeiia?aeaoe iniaeeainoyi iaoieia?/iiai i?ioeano o aeeoaeueieo oeyoao. A yeino? aaciai? ??aeeie aeey naiaoe?e, ?iaaeyoe?e ? ?inoeeyoe?e aeei?enoiaoaaee noa?eeueiee i?ae?a??oee aei 37iN 0,9% ?ic/ei NaCl. Aeey iioei?caoe?? a?io?i?/ieo aeanoeainoae a?iio?aeueiiai nae?aoo ei?aaoethaaee ?I ?ic/eio. I?e e?eoaaii? eaoa?aeueiiai aiaeia?iio?oo a?i neeaaeaa 7,2, ai?eiiai - 5,9-6,0. O oai?eo c eaoa?aeueiei aiaeia?iio?oii ? neeciaith a?ia?nae?aoe??th aa?icieue-oa?ai?y i?iaiaeeeanue 3-4 ?ace ia aeaiue. C iaoith iie?ioaiiy ?aieia?/ieo aeanoeainoae a?iio?aeueiiai nae?aoo ? a?aeiiaeaiiy no?oaeoaioa aei neeaaeo ??aeeie aeey ?? i?iaaaeaiiy aaiaeeee eacieaai ii 15 ia ? o??inei ii 10 ia ia 1 ?iaaeyoe?th. I?e eaoa?aeueiiio aiaeia?iio?o? c? neeciai-ai?eiith a?ia?nae?aoe??th 1 ?ac ia aeiao i?iaiaeeee o?aino?aoaaeuei? ?inoeeyoe??, a e?euee?noue ?iaaeyoe?e nei?i/oaaee aei 2 ia aeaiue. Aei neeaaeo ??aeeie aeey naiaoe?e OAAe aeiaeaoeiai aeeth/aee: 4% ?ic/ei aoeaoeeoeenoa?io 2-4 ia, 0,1% ?ic/ei aaeanei?a?io - 5 ia ? 6% ?ic/ei o?ai?io a?ii?aeo - 1 ia (c iaoith iie?ioaiiy ?aaaia?aoe?? a?yeueiiai ai?oae?th), aeico eacieaaio ia 1 ?iaaeyoe?th ca?eueooaaee aei 25 ia. I?e ai?eiiio aiaeia?iio?o?, a oaeiae o iaoe??io?a c iiieaeaiei eaoeaaei ?aoeaenii iaea?eueo aoaeoeaiei iaoiaeii naiaoe?? OAAe, o ia?a?aao i?ae a?iioineii?yie, aoea ?inoeeyoe?y e?ea?nueeeo ?a/iaei ca aeiiiiiaith eaoaoa?ecaoe?? o?aoa? ii 5-10 ie ?ic/eio ia eiaeio ?c eaaai?a 1-3 ?ace ia aeiao. sse?niee neeaae ??aeeie i?e oeueiio ia a?ae??ciyany a?ae iienaiiai aeua. Aeiaeaoeiai oeei iaoe??ioai aioo??oiueiaaiii aaiaeeee eacieaai ii 15 ia 2 ?ac ia aeaiue. I?e i?iaaaeaii? i?iaeiaaeaii? OAE, c iaoith iioei?caoe?? ooieoe?eiiai noaio aiaeioae?ioeeo?a eaaaiaaeo eai?ey??a aioo??oiueiaaiii aaiaeeee iaioieneo?e?i (na?aaeiy aeiaiaa aeica 150 ia). ?iooc?eia ? iaaeeeaiaioicia oa?ai?y o oai?eo iaio a?oi i?iaiaeeeanue ca noaiaea?oieie iaoiaeeeaie. Aiae?c ?acoeueoao?a aeine?aeaeaiue a?iioieaaaiaai? nenoaie a 1 noaae?? AAN iieacaa, ui a?aeiiaeaiiy iieaciee?a ooieoe?? ciai?oiueiai aeeoaiiy, eeneioii-iniiaiiai noaio ? aaciaiai neeaaeo e?ia? o oai?eo a i?ioean? i?iaaaeaiiy aeeoa?aioe?eiaaii? ??O a?aeaoaaeinue i?eaeecii o o? ae no?iee, ui ? a I a?oi? oai?eo. I?e oeueiio aoei anoaiiaeaii, ui ii?yae c? oaeaeoei iie?ioaiiyi aiaeineii?/ii? ea?oeie, aeeoa?aioe?eiaaia ??O ni?eyea cia/iei ci?iai ? a a?io?i?/ieo iieacieeao a?iio?aeueiiai nae?aoo. Oae, aaea ia 2 aoai? aeine?aeaeaiiy ?I a?iio?aeueiiai nae?aoo o oai?eo II a?oie cieceany aei 7,21±0,17, e?euee?noue caaaeueiiai a?eea aei 7,5±0,9a/e, eiioeaio?aoe?y n?aeiaeo eeneio ciaioeeanue aei 86,6±6,8 oi.iae., a eiioeaio?aoe?y io?ai?aeace ae?inea aei 4,55±0,65 a/e. Aiaeia?/i? iieacieee o oai?eo I a?oie neeaaeaee: 7,5±0,3, 10,32±1,15 a/e, 113,4±11,6 oi. iae. ? 2,8±0,7 a/e, a?aeiia?aeii. Ia 12-15 aeiao aeeoa?aioe?eiaaii? ??O ?I a?iio?aeueiiai nae?aoo ii?iae?coaaany ? aoa ia 0,36±0,28 ieae/a, i?ae o oai?eo I a?oie (oaae.2). Oaaeeoey 2 Aiioiii/ii iieacieee a?iioiaeueiiai nae?aoo o oai?eo c AAN ia 12-15 aeiao I?O (M±m) A?oia oai?eo?IAieie, a/eNiaeiai eeneioe, oi.iaeIo?aiiaeaca, a/eI. 1 noaaeiy AAN 2 noaaeiy AAN7,4±0,3** 7,4±0,3**9,8±2,0** 11±2**110±14** 121±10**3,1±0,4** 1,6±0,4**II.1 noaaeiy AAN 2 noaaeiy AAN7,0±0,1 7,1±0,26,8±0,8* 8,2±1,7*54,0±5,4* 103±9*5,0±0,4* 4,9±1,6*Eiio?ieueia a?oia7,2±0,20,7±0,124±56,3±1,2I?eiioea: iaeia ci?i/ea - aiaeiiiiinoi aeinoiai?ii o ii?iaiyiii c eiio?ieai (i?e ?<0,001), 2 - iiae a?oiaie. ?AeAA o oai?eo ? a?oie cieaeoaaany eeoa ia 12-15 aeiao e?eoaaiiy; a oie /an, ye oeae iieaciee o oai?eo ?? a?oie aaea ia 2 aoai? aeine?aeaeaiiy aoa a??ia?aeii aeeae/a aei eiio?ieth. Iiceoeaiee aieea iaoiae?a aeeoa?aioe?eiaaii? ??O ia eeth/ia? ianiaoeeo?/i? iaoai?cie aioe?ioaeoe?eiiai caoenoo i?aai?a aeeoaiiy ciaoiaeea nai? a?aeia?aaeaiiy o iie?ioaii? aeaieo aaeoa??ieia?/ieo aeine?aeaeaiue. Oae, o oai?eo II a?oie a?aecia/aeinue cieaeaiiy aen?yiino? iaoiaaiii? i?e?ioei?e c 40% aei 30% ? ca?eueoaiiy /enea noa?eeueieo iin?a?a aei 7, i?ioe 4 o oai?eo ? a?oie. O ii??aiyii? c I a?oiith ia 2 aoai? aeine?aeaeaiiy, e?euee?noue aeeoo?caeaoieo AI o oai?eo II a?oie ca?eueooaaeanue o na?aaeiueiio aei 72±3%, O* aei 41,6±2,2%, a O? aei 7,12±1,5 i?ioe 64±3%, 34±2% ? 5,66±1,09 a ? a?oi? oai?eo a?aeiia?aeii. Ia oaeaeoa ciaioaiiy caiaeueiiai i?ioeano o OAAe o oai?eo ?? a?oie aeacoaaei cieaeaiiy /enea INO iiceoeaieo AI o 1,5 ?ace, a oie /an, eiee oeae iieaciee o oai?eo ? a?oie ia ci?ieany. NOeE n-INO-oanoa o oai?eo ?? a?oie neeaaeaa 0,94±0,06, a o ? a?oi? 0,70±0,03. Aiaeia?/ia ni?yiiaai?noue o a?aeiiaeaii? ooieoe?eii? aeoeaiino? AI caa??aaeanue ? ia 3 aoai? aeine?aeaeaiiy (oaae.3). Oaaeeoey 3 Iniiaii iieacieee ooieoeieii? aeoeaiinoi AI o oai?eo c AAN ia 12-15 aeiao I?O A?oia oai?eoAEeoo?caeaoiinoue AI, %O*, % OI N-INO-oano, % n-INO-oano (NOeE)I. 1 noaae?y AAN 2 noaae?y AAN75±4* 45±3*39±3* 30±5*6,2±1,3* 4,2±1,0*20±5* 28±5*0,7±0,1* 0,7±0,1*II. 1 noaae?y AAN 2 noaae?y AAN82±3** 67±4**49±2** 47±5**9,2±1,2** 8,8±1,2**16±2** 20±1**0,86±0,04** 0,99±0,10**Eiio?ieueia a?oia88±247±37,3±1,311±20,64±0,04I?eiioea: iaeia ci?i/ea - aiaeiiiiinoi aeinoiai?ii o ii?iaiyiii c eiio?ieai (i?e ?<0,001), 2 - iiae a?oiaie. A oie aea /an aeeoa?aioe?eiaaia ??O ia iaea ae?aciiai iiceoeaiiai aieeao ia aoii?aeueio eaieo ?AeN. Aeyaeeinue, ui ia an?o aoaiao ??O aeinoia??ii? ci?ie ci?noo SIgA o a?iio?aeueiiio nae?ao? iii?/aii ia aoei a iaio a?oiao (iae.1). wmetafile8? ??Rz????0z??????????? ??????? y?u????0z??C ?I???y?u????y?u????(???u??y????????? ????????????????????????????? ?? ? ???????????????? ?? ?? ?!!!?"""?###?$$$?%%%?&&&?'''?(((?)))?***?+++?,,,?---?...?///?000?111?222 ?333?444?555?666?777?888?999?:::?;;;?<<>>?????@@@?AAA?BBB?CCC?DDD
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Eiio?ieue1 aeiaa5-7 aeiaa12-15 aeiaaSIgA 1 a?oiaSIgA 2 a?oiaIgG 1
a?oiaIgG 2 a?oia

Iae.1. Ii?iaiyeueia ioeiiea noaio aoii?aeueiiai iioiioaoo aeeoaeueii?
nenoaie o oai?eo a 1 noaaei? AAN ia ?icieo aoaiao I?O.

?acii c oeei, ci?no IgG ia 2 ? 3 aoaiao aeine?aeaeaiiy o oai?eo ??
a?oie aoa aeinoia??ii aeua, i?ae o oai?eo ? a?oie. Iia’ycaii oea aoei c
iie?ioaiiyi eiiia?aoeaii? aca?iiae?? ?ioiieiiiaoaioieo ee?oei a
aeenoaeueieo a?aeae?eao a?iio?a o ?acoeueoao? a?eueo aoaeoeaiiai
onoiaiiy caiaeueieo ci?i a OAAe o oai?eo 2 a?oie.

O 2 noaae?? AAN, aea ??O i?iaiaeeeanue aac OAE, aaea ia 5-7 aeiao o
oai?eo a iaio a?oiao a?aeiiaethaaeanue a?iio?aeueia i?io?aei?noue. A oie
aea /an, aiaeineii?/ia ea?oeia cai?ioiiai ?icaeoeo caiaeueiiai i?ioeano
o OAAe aoea a?eueo ae?aaeaia i?e i?iaaaeaii? aeeoa?aioe?eiaaii? ??O. O
a?oi? oai?eo, aea i?iaiaeeeanue OAE, aoei anoaiiaeaii, ui aiia
iani?eyoeeai aieeaa? ia ia?aa?a caiaeueiiai i?ioeano a i?aaiao aeeoaiiy.
Aeyaeeinue, ui OAE caeaoia noaa?e?coaaoe ? iaa?oue, ia??aeei,
aeoea?coaaoe oeae i?ioean. I?e oeueiio aoaeoeai?noue ??O o i?ioean? OAE
cieaeoaaeanue.

Aiae?c a?io?i?/ieo ?acoeueoao?a aeine?aeaeaiue iieacaa, ui oae, ye ? o 1
noaae?? AAN, o 2 noaae?? aeeoa?aioe?eiaaia ??O a?eueo ae?acii iiceoeaii
aieeaaea ia iniiai? iieacieee a?iio?aeueiiai nae?aoo. Oae, o ?? a?oi?
oai?eo, ia 2 aoai? aeine?aeaeaiiy ?I a?iio?aeueiiai nae?aoo neeaaeaa
7,4±0,2, eiioeaio?aoe?y caaaeueiiai a?eea 9,7±1,4 a/e a oie /an, eiee o
? a?oi? oe? iieacieee neeaaeaee: 7,67±0,29 ? 12,13±1,26 a/e,
a?aeiia?aeii. Ci?no n?aeiaeo eeneio o a?iio?aeueiiio nae?ao? o oai?eo ??
a?oie ia 2 aoai? aeine?aeaeaiue aoa ia 17,4±1,61 oi.iae., a ia 3 aoai?
ia 18,5±1,6 oi.iae. ieae/a, i?ae o oai?eo ? a?oie. Ia 3 aoai?
eiioeaio?aoeiy io?aiiaeace o oai?eo ?? a?oie aeyaeeanue aeua ia 2,9±0,8
a/e (aeea. oaae.2).

?AeAA o oai?eo ? a?oie ia an?o aoaiao ??O i?aeoe/ii ia ci?ithaaany, a a
niinoa?aaeaiiyo, aea i?iaiaeeeanue OAE a??ia?aeii c?inoaa. Iai?ioe, o
oai?eo ?? a?oie oeae iieaciee ia 3 aoai? aeine?aeaeaiiy a??ia?aeii
cieaeoaaany, ui aeacoaaei ia iie?ioaiiy ooieoe?eiiai noaio a?yeueiiai
ai?oae?th i?e canoinoaaii? aeeoa?aioe?eiaaii? ??O.

Iieiioaiiy aiioiii/ieo iieacieeia a?iioiaeueiiai nae?aoo, cieaeaiiy
nooiaiy ae?aciino? caiaeueieo ciii o OAAe a oiiaao aeeoa?aioeieiaaii?
I?O noi?iaiaeaeoaaeinue ciiiaie o aaeoa?iaeueiiio niaeo?i aeniyii? c
aeeoaeueieo oeyoia iie?ioei?e. Ia 12-15 aeiao aeeoa?aioeieiaaii? I?O o
oai?eo iiii/aeinue cia/ia caieueoaiiy aeniyiinoi nai?ioioii? oei?e c
?iaeo iaena?ie aei 45% i?ioe 4,2% i eeaani?e aei 24% i?ioe 4,4%, o
ii?iaiyiii c ? a?oiith oai?eo. Ia oeueiio oiii o ?? a?oii aiaeaoaaeinue
cieaeaiiy aeniyiinoi iaoiaaiieo eoeueoo? noao?eieiea aei 5% i?ioe 8,5%,
no?aioieiea aei 10% i?ioe 19,4% i a?aiaiae’?iieo aioa?iaaeoa?ie i
nei?aiieii? iaee/ee aei 16% i?ioe 30,2% o oai?eo a ? a?oii.

Ii?iaiyeueiee aiaeic ooieoeieiiai noaio AI, i?iaaaeaiee o oai?eo ? i ??
a?oi, iieacaa, ui a oiiaao aeeoa?aioeieiaaii? I?O aiaeiiaeaiiy iniiaieo
ia?aiao?ia, ui oa?aeoa?ecothoue oaaioeeoa?io aeoeaiinoue oeeo eeioei,
aiaeaoaaeinue o aieueo iiaiiio ia’?ii i a aieueo ?aiii no?iee. O ??
a?oii oai?eo ia 5-7 aeiao I?O eieueeinoue aeeoo?caeaoieo AI
caieueoeeanue aei 42±3%, O* i OI — aei 30±4% i 4,60±0,87. Aiaeiai/ii
iieacieee o ? a?oii neeaaeaee: 40±3%, 23±5%, 3,01±1,04, aiaeiiaiaeii.
Eieueeinoue n-INO-iiceoeaieo AI aoea ieae/ith o ?? a?oii ia 14,2±0,1, a
NOeE INO-oanoa aoa o oeueiio aeiaaeeo aeua ia 0,09±0,01. Ciiie
iieacieeia ooieoeieii? aeoeaiinoi AI ia 3 aoaii a iaio a?oiao iaee
noiaeo iai?aaeaiinoue, aea ?icio nooiiiue ?o aiaeiiaeaiiy. A ? a?oii
caa?iaaeenue ae?aaeaii ii?ooaiiy aeeoo?caeaoiinoi i aaeoa?eoeeaeii?
aeoeaiinoi AI (aeea. oaae.3).

Ia 5-7 aeiao eieoaaiiy o oai?eo o ?? a?oii aeinoiai?iiai ?inoo
eiioeaio?aoei? SIgA o a?iioiaeueiiio nae?aoi iiii/aii ia aoei, ye o
ii?iaiyiii c 1 aoaiii aeineiaeaeaiiy , oae i a ii?iaiyiii c 2 aoaiii o ?
a?oii (iae.2).

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?I???|?u????|?u????(???u??|?????????oe?????????????????????
??????? ?? ?
???????????????? ??

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?EEE?FFF?GGG?HHH?III?JJJ?KKK?LLL?MMM?NNN?OOO?PPP?QQQ?RRR?SSS?TTT?UUU?VVV
?WWW?XXX?YYY?ZZZ?[[[?]]]?^^^?___?«`?aaa?bbb?ccc?ddd?eee?fff?ggg?hhh?iii
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SIgA ? a?oiaS?gA ?? a?oiaIgG ? a?oiaIgG ?? a?oia

Iae.2. Ii?iaiyeueia ioeiiea noaio aoii?aeueiiai iioiioaoo aeeoaeueii?
nenoaie o oai?eo a 2 noaaei? AAN ia ?icieo aoaiao I?O.

Aieueoa oiai, iecueei eiioeaio?aoei? SIgA i ?gG caa?iaaeenue ia anio
aoaiao aeineiaeaeaiiy i aeinoiai?ii ia aiae?iciyeenue aiae oaeeo o
oai?eo o ? a?oii. Iia’ycaii oea aoei c iaaaoeaiei aieeaii OAE ia IAeN.

Iacaaaeath/e ia oea, aeeoa?aioeieiaaia I?O ni?eyea, a eiioeaaiio
?acoeueoaoi, iiaeaeuaiith aoaeoeaiinoi eieoaaiiy oai?eo c AAN (iae.3).

wmetafile8? ???‘????j‘??????????? ??????? ?? ????j‘??C
?I????? ?????? ????(??? ????????????aAIie?ioaiiyCaaaeueia
eaoaeuei?noueEaoaeuei?noue i?e OAE

Iae 3. Ii?iaiyeueia aoaeoeaiinoue o?aaeeoeieii? (a) i aeeoa?aioeieiaaii?
(a) I?O i?e AAN.

Oae, yeui a ? a?oii oai?eo cia/ia iieiioaiiy aoei aeinyaiooa a 60%
niinoa?aaeaiue, oi a ?? a?oii oeae iieaciee ae?in aei 90,6% aai aieueoa,
iiae a 1,5 ?ace. E?ii oiai, a oeo niinoa?aaeaiiyo, aea i?iaiaeeeanue
OAE, na?aaeiy ?? o?eaaeinoue cieaeoaaeanue ia 1,5 aeiae, a iio?aaa o iie
ia 8,25%. I?e oeueiio cieaeoaaeanue eaoaeueiinoue. A ?? a?oii aiia iaea
6,25% i?ioe 12,5% a ? a?oii, aai a 2 ?ace iaioa. E?ii oiai, ia 7,5% aai
a 1,6 ?ace cieaeoaaeanue eaoaeueiinoue i?e OAE.

AENIIAEE

1. Aaaeo/ei iaoaiiciii ?icaeoeo i iiaeo?eiee AAN ? iano?oeoeaii
ii?ooaiiy o aeeoaeueieo oeyoao, yei aeieeathoue o ?acoeueoaoi caiaeueieo
ciii c aieo neeciai? iaieiiee o?aoa? i a?iioia. Noaaeiy aiaeiinii?
eiiiainaoei? AAN oa?aeoa?eco?oueny aenieith /anoioith aeyaeaiiy
eaoa?aeueiiai aiaeia?iioioo. O noaaei? aeaeiiiainaoei? i?aaaeth? aiieiee
aiaeia?iioio. O aaeoa??ieia?/ieo iin?aao aeii?io? a?aiiiceoeaia
iaoiaaiia i?e?ioei?a.

2. I?e AAN aeieeathoue ae?aaeaii ii?ooaiiy a ianiaoeeoi/ieo i
niaoeeoi/ieo caoenieo iaoaiiciao i?aaiia aeeoaiiy: iiaeaeuo?oueny IAeAA,
?I a?iioiaeueiiai nae?aoo, ciino o iueiio caaaeueiiai aieea i niaeiaeo
eeneio; cieaeo?oueny ooieoeieia aeoeaiinoue AI, eiioeaio?aoeiy
io?aiiaeace, SIgA i IgG, niinoa?iaa?oueny iiyaa neiaeiaeo eiioeaio?aoeie
IgM.

3. O oai?eo c AAN inio? caeaaeiinoue iiae ciiiaie o IAeN i nooiaiai
ae?aciino? AAeI. O ia?oie noaaei? AAN noai IAeN oa?aeoa?eco?oueny
aiaeiiniith aai ae?aaeaiith iai?oaith, o ae?oaie noaaei? AAeI aii
aiaeiiaiaea? noaaei? aeaeiiiainaoei?.

4. O?aaeeoeieia I?O aeinoiai?ii iieiioo? iieacieee ianiaoeeoi/iiai
caoenoo i?aaiia aeeoaiiy. Cieaeo?oueny ?I a?iioiaeueiiai nae?aoo, o
iueiio iiaeaeuo?oueny ciino io?aiiaeace, c?inoa? ooieoeieia aeoeaiinoue
AI. O aaeoa??ieia?/ieo iin?aao aeii?io? a?aia?ae’?iia iaoiaaiia oa
oiiaii-iaoiaaiia i?e?ioei?a.

Aoaeoeaiinoue I?O aeua i?e eaoa?aeueiiio aiaeia?iioioi, i?e aiieieo
oi?iao caiaeaiiy o OAAe aiia cieaeo?oueny.

5. OAE i /anoi o?aoaia?iioiaeueii eaaaaei iaaaoeaii aieeaathoue ia
niaoeeoi/ii iaoaiicie IAeN. O i?ioeani i?iaaaeaiiy OAE, ca ?aooiie
iayaiinoi ?icaeoaii? iaiaeaoee, i?aeoe/ii i?eieiy?oueny iaaeoiaeaeaiiy
SIgA c aa?oiio aiaeaeieia aeeoaeueieo oeyoia o ieaeii. I?e eaaaaeao OAAe
aiaeaoaa?oueny anii?aoeiy c aeeoaeueieo oeyoia iioiieiiiaoaioieo eeioei
i iioiiaeiaoeiiia, a iaoaii/ia o?aaiaoecaoeiy neeciai? iaieiiee cieaeo?
?o nae?aoeith.

6. Aeeoa?aioeieia I?O iiaeiia aoaeoaaoenue c a?aooaaiiyi noaaei? AAeI i
nooiaiy ii?ooaiue a IAeN. Aiia ni?ey? aieueo oaeaeeiio aiaeiiaeaiith
iniiaieo iieacieeia aioeiioaeoeieiiai caoenoo i?aaiia aeeoaiiy ye i?e
eaoa?aeueiiio, oae i i?e aiieiiio aiaeia?iioioi. Ii?iaeico?oueny ?I
a?iioiaeueiiai nae?aoo, aiaeiiaeth?oueny ooieoeieia aeoeaiinoue AI,
ciino io?aiiaeace caieueoo?oueny aei eiio?ieueieo aaee/ei (90-98%);
ciaioo?oueny nooiiiue ae?aciino? caiaeueieo ciii o OAAe i /anoioa
?icaeoeo iioaeoeieieo oneeaaeiaiue a i?aaiao aeeoaiiy. A
aaeoa??ieia?/ieo iin?aao aeii?io? a?aia?ae’?iia oiiaii-iaoiaaiia
nai?io?oia i?e?ioei?a. Caa?iaa?oueny aeaoioeeo o niaoeeoi/iie eaioei
IAeN.

7. Aeeoa?aioeieia canoinoaaiiy iaoiaeia I?O i?e AAN ni?ey? cieaeaiith
caaaeueii? eaoaeueiinoi ia 6,25%, a eaoaeueiinoi i?e OAE ia 7,5% i
nei?i/aiith no?ieia ?? i?iaaaeaiiy ia 1,5 aeiae.

8. Iaeiei ic iaoiaeia iiaeaeueoiai oaeineiiaeaiiy aeeoa?aioeieii?
iioaineaii? ?anii?aoi?ii? oa?aii? o oai?eo c AAN iiaea aooe ?ic?iaea i
caeo/aiiy aei ?? eiiieaeno iinoeaai? iioiiiiaeoethth/i? oa?aii?.

I?aeoe/i? ?aeiiaiaeaoe??

1. I?e AAN iaiao?aeii canoiniaoaaoe aeeoa?aioe?eiaaio ??O, yea
aoaeo?oueny c iaia’yceiaei a?aooaaiiyi noaae?? AAeI, aeaeo aiaeia?iio?oo
? nooiaiy ii?ooaiue o i?noeaaeo caoenieo iaoai?ciao i?aai?a aeeoaiiy.

2. I?e 1 noaae?? AAN c yaeuaie eaoa?aeueiiai aiaeia?iio?oo onoiaiiy
a?iio?aeueii? iano?oeoe?? cae?enith?oueny ca aeiiiiiaith a?iioineii?/ieo
naiaoe?e c ?ioa?aaeii 7-8 aei?a ? ?iaaeyoe?eii? oa?ai??. O yeino?
aaciai? eaaaaeii? ??aeeie aeei?enoiao?oueny 0,9% ?ic/ei NaCl c
ei?aaoeueiaaiei ?I 7,2.

3. I?e 2 noaae?? AAN c yaeuaie ai?eiiai aiaeia?iio?oo ia?aaaao ne?ae
a?aeaeaaaoe naiaoe?? OAAe /a?ac aiaeio?aoaaeueio o?oaeo. I?ney onoiaiiy
aeaeiiiainaoe?? o aaciiai?i? a?iioineii?? i?iaiaeyoueny c ?ioa?aaeii 4-5
aei?a ? aeiiiaiththoueny o?aino?aoaaeueieie ?inoeeyoe?yie. O yeino?
aaciai? eaaaaeii? ??aeeie canoiniao?oueny 0,9% ?ic/ei NaCl c
ei?aaoeueiaaiei ?I 5,9-6,0.

4. Aei neeaaeo ?ic/ei?a aeey naiaoe?e, ?iaaeyoe?e ? ?inoeeyoe?e
iaiao?aeii aeeth/aoe aiaei?ic/eii? i?aia?aoe c aioeieneaeaioieie
aeanoeainoyie (aaeanei?a?i, aoeaoeeoeenoa?i) ? iiia?aaeieee no?oaeoaioa
(eacieaai).

5. I?e i?iaaaeaii? i?iaeiaaeaii? OAE ??O aeiiiaith?oueny
aioo??oiueiaaiiei aaaaeaiiyi iaioieneo?e?io.

NIENIE IIOAE?EIAAIEO I?AOeUe

1. Nieoeui I.I., Naoeooa N.A. Aeeooa?aioee?iaaiiay eioaineaiay
?anie?aoi?iay oa?aiey i?e anoiaoe/aneii noaoona // A?niee i?iaeai
a?ieia?? ? iaaeeoeeie. – 1998. — ? 18 . – N.89-96.

2. Naoeooa N.A. Aeaye? i?aenoiee oa ia?niaeoeae aeine?aeaeaiiy ?ioi?oaoo
aeeoaeueii? nenoaie o oai?eo c aino?ith aeeoaeueiith iaaeinoaoi?noth
(iaeyae) // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1998. — ? 23 . –
N.97-104.

3. Naoeooa N.A. Aeeiaieea iaeioi?uo iieacaoaeae ioeioeeeea?iiai eee?aina
o aieueiuo n a?iioianoiaoe/aneei noaoonii a i?ioeanna i?iaaaeaiey
eioaineaiie ?anie?aoi?iie oa?aiee // A?niee i?iaeai a?ieia?? ?
iaaeeoeeie. – 1998. — ? 23 . – N.104-107.

4. Nieoeui I.I., Naoeooa N.A. Aeeyiea eioaineaiie ?anie?aoi?iie oa?aiee
ia aioeeioaeoeeiiioth caueoo e eiioiioth ?aaeoeaiinoue i?aaiia aeuoaiey
o aieueiuo n a?iioianoiaoe/aneei noaoonii // Ainiee i?iaeai aiieiai? ?
iaaeeoeeie. — 1998. — ?. 24 — N.33-37.

5. Naoeooa N.A. ?ieue aioeeioaeoeeiiiie caueou e eiioiiie ?aaeoeaiinoe
i?aaiia aeuoaiey a ?acaeoee ainiaeeoaeueiuo ineiaeiaiee e IAeI o
aieueiuo n a?iioeaeueiie anoiie // Oe?a?inueeee iaaee/iee aeueiaiao. —
1998. — ?1. — N.63-68.

6. Nieoeui I.I., Naoeooa N.A. Ea/aiea ino?ie aeuoaoaeueiie
iaaeinoaoi/iinoe o aieueiuo n a?iioeaeueiie anoiie // Iaoa?. XIV
Iaoe?iiaeueiiai c’?caeo oa?aiaao?a.- Ee?a, 1998. – N.21.

7. Nieoeui I.I., Naoeooa N.A., Ieeiiiaa A.I. Eneonnoaaiiay aaioeeyoeey
eaaeeo e ianoiue eiioieoao i?e a?iioianoiaoe/aneii noaoona //
Iaeeeaoeaiay iaaeeoeeia e ?aaaeeeoaoeey a cae?aaiio?aiaiee: Na. iao/iuo
?aaio II eiia?anna n iaaeaeoia?iaeiui o/anoeai .- Iineaa, 1998. – N.123.

8. Naoeooa N.A. Ia?aaeeaia iiieoi?eiaa ianoiiai eiioieoaoa i?aaiia
aeuoaiey o aieueiuo n a?iioeaeueiie anoiie // Iaeeeaoeaiay iaaeeoeeia e
?aaaeeeoaoeey a cae?aaiio?aiaiee: Na. iao/iuo ?aaio II eiia?anna n
iaaeaeoia?iaeiui o/anoeai .- Iineaa, 1998. – N.123.

9. Naoeooa N.A. Ooieoeeiiaeueiay niiniaiinoue ia?oeaoaeueiiai yieoaeey
o?aoaia?iioeaeueiiai aea?aaa (OAAe) o aieueiuo n a?iioianoiaoe/aneei
noaoonii (AAN) // Ca. oac. aeii. II I?aeia?iaeiiai iaaee/iiai eiia?ano
nooaeaio?a ? iieiaeeo a/aieo.- Oa?iii?eue, 1998.- N.131.

10. Naoeooa N.A. Aeeiaieea aaeoa?eia?aiiu a?iioeaeueiiai nae?aoa (AN) o
aieueiuo n a?iioianoiaoe/aneei noaoonii (AAN) a i?ioeanna i?iaaaeaiey
eioaineaiie ?anie?aoi?iie oa?aiee (E?O) // Ca. oac. aeii. II
I?aeia?iaeiiai iaaee/iiai eiia?ano nooaeaio?a ? iieiaeeo a/aieo.-
Oa?iii?eue, 1998.- N.219.

11. Naoeooa N.A. Aeeyiea eneonnoaaiiie aaioeeyoeee eaaeeo (EAE) ia
eiioieoao aeuoaoaeueiie nenoaiu (EAeN) o aieueiuo n anoiaoe/aneei
noaoonii (AN) // Aianoaceieiaey e ?aaieiaoieiaey ia ?oaaaea XXI aaea:
Iaoa?. thaeeaeiie iao/.- i?aeoe/. eiio., iinayu. 25-eaoeth eaoaae?u
aianoaceieiaee e ?aaieiaoieiaee Aeiai?iiao?ianeie ainoaea?noaaiiie
iaaeeoeeineie aeaaeaiee.- Aeiai?iiao?iane, 1998.- N.116-117.

AIIOAOeIss

Naoeooa N.A. Aeeoa?aioeieiaaia iioaineaia ?anii?aoi?ia oa?aiiy oa ??
aieea ia aioeiioaeoeieiee caoeno i?aaiia aeeoaiiy o oai?eo c
a?iioianoiaoe/iei noaoonii. — ?oeiien.

Aeena?oaoeiy ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoeiaeueiinoth 14.01.30 — aianoaciieiaiy oa iioaineaia oa?aiiy. –
Aeiii?iiao-?ianueea aea?aeaaia iaaee/ia aeaaeaiiy, Aeiii?iiao?ianuee ,
1999.

Aeena?oaoeiy i?enay/aia aeooaeueiei ieoaiiyi iioaineaii?
?anii?a-oi?ii? oa?aii? a?iioianoiaoe/iiai noaoono. O ?iaioi iieacaii,
ui o?aaeeoeieia iioaineaia ?anii?aoi?ia oa?aiiy ia aiaeiiaeth? ii?ooaiee
iioiioao aeeoaeueii? nenoaie o oeeo oai?eo. Aeinoaea iiaeaeueoee
?icaeoie eiioeaioeiy aeeoa?aioeieiaaiiai canoinoaaiiy iaoiaeia I?O o
caeaaeiinoi aiae noaaei? aino?i? aeeoaeueii? iaaeinoaoiinoi i ii?ooaiue
o IAeN. Oaeineiiaeaii iaoiaeeeo eieoaaiiy oai?eo c AAN, yea ni?ey?
i?aeoe/ii iiaiiio aiaeiiaeaiith ianiaoeeoi/ieo eaiie IAeN.

Cai?iiiiiaaii iaoiaee eieoaaiiy aeicaieythoue cieceoe caaaeueio
eaoaeueiinoue i?e AAN ia 6,25%, a eaoaeueiinoue i?e ooo/iie aaioeeyoei?
eaaai?a ia 7,5%.

Eeth/iai neiaa: a?iioianoiaoe/iee noaoon, iioaineaia ?anii?aoi?ia
oa?aiiy, iioiioao aeeoaeueii? nenoaie.

AIIIOAOeEss

Naoeooa N.A. Aeeooa?aioee?iaaiiay eioaineaiay ?anie?aoi?iay oa?aiey e aa
aeeyiea ia aioeeioaeoeeiiioth caueoo i?aaiia aeuoaiey o aieueiuo n
a?iioianoiaoe/aneei noaoonii. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo
iaoe ii niaoeeaeueiinoe 14.01.30. — aianoaceieiaey e eioaineaiay
oa?aiey. — Aeiai?iiao?ianeay ainoaea?noaaiiay iaaeeoeeineay aeaaeaiey,
Aeiai?iiao?iane, 1999.

A iniiao ?aaiou iieiaeaiu aeaiiua eeeie/aneiai iaaethaeaiey,
ianeaaeiaaiey e ea/aiey 120 aieueiuo n a?iioianoiaoe/aneei noaoonii
(AAN), ?acaeaoainy ia oiia eioaeoeeiiii-caaeneiie a?iioeaeueiie anoiu.
Aeey ii?aaeaeaiey noaiaie oyaeanoe caaieaaaiey eniieueciaaia
eeanneoeeaoeey anoiaoe/aneiai ninoiyiey AIEE ioeueiiiieiaee a
iiaeeoeeaoeee A.E.O?aueineiai n niaao.,1985.

Ana ianeaaeiaaiiua aieueiua, n o/aoii i?eiaiyaiie iaoiaeeee eioaineaiie
?anie?aoi?iie oa?aiee (E?O) e niaeanii oeacaiiie eeanneoeeaoeee, auee
iiaeaeaiu ia 2 a?oiiu ii 60 /aeiaae.

1 a?oiia: 20 aieueiuo a noaaeee ioiineoaeueiie eiiiainaoeee e 40
aieueiuo a noaaeee aeaeiiiainaoeee ino?ie aeuoaoaeueiie iaaeinoaoi/iinoe
(IAeI). A yoie a?oiia i?eiaiyeny o?aaeeoeeiiiue iiaeoiae e E?O AAN.

2 a?oiia: 28 aieueiuo a noaaeee ioiineoaeueiie eiiiainaoeee IAeI e 32
iaoeeaioa a noaaeee aeaeiiiainaoeee. A yoie a?oiia aieueiuo i?eiaiyeanue
aeeooa?aioee?iaaiiay E?O.

Eiio?ieueioth a?oiio ninoaaeee 20 iaoeeaioia aac a?iioieaai/iie
iaoieiaee.

Iniaia aieiaiea auei oaeaeaii eco/aieth ianiaoeeoe/aneeo e
niaoeeoe/aneeo caaiueaa ianoiie caueou eaaeeo.

I?e aeioeie/aneii enneaaeiaaiee eco/aeny ?I o?aoaia?iioeaeueiiai nae?aoa
( n iiiiuueth ioa/anoaaiiiai ?I-iao?a), niaea?aeaiea a iai iauaai aaeea
( aeo?aoiaui iaoiaeii), neaeiauo eeneio (iaoiae Aanna).

Ianiaoeeoe/aneea iaoaieciu ianoiie caueou i?aaiia aeuoaiey eco/aeenue ii
eiaeaeno aeaaaia?aoeee ia?oeaoaeueiiai yieoaeey (EAeIY) ii iaoiaeo
A.ss.Ineieia e E.A.Iaoaaaaie, ii ooieoeeiiaeueiie aeoeaiinoe
aeueaaiey?iuo iae?ioaaia (AI) ii iaoiaeeeai A.A. Aa?aneia e
Ae.I.Iayineiai e niaea?aeaieth a ieo aioeaaeoa?eaeueiiai oa?iaioa
io?aieaeacu ii iaoiaeeea A.O.*a?iooaiei e A.N.Eiainiaie.

Niaoeeoe/aneea iaoaieciu ianoiie caueou i?aaiia aeuoaiey eco/aeenue ii
niaea?aeaieth a a?iioeaeueiii nae?aoa eiioiiaeiaoeeiia eeannia A, G e I
iaoiaeii eiioiiaeeoocee ii Iai/eie — ii iaoiaeeea I.E.Ei?ieue e
A.I.Iieiaeoeiaie.

Enneaaeiaaiey auiieiyeenue i?e iinooieaiee aieueiuo (1-2 nooee), ia 5-7
nooee ea/aiey e iinea aai ieii/aiey (12-15 nooee). ?acoeueoaou
enneaaeiaaiee iiaeaa?aaeenue noaoenoe/aneie ia?aaioea.

Aiaeec ?acoeueoaoia enneaaeiaaiee, i?iaaaeaiiuo o aieueiuo iaaeo a?oii
ia 1 yoaia iieacae, /oi ia?ooaiey a aioeeioaeoeeiiiie caueoa i?aaiia
aeuoaiey iineee ?aciiiai?aaeaiiue oa?aeoa? e caaenaee io noaaeee AAN e
aeaea yiaeia?iioeoa. Oae, a n?aaiaiee n eiio?ieueiuie iieacaoaeyie, a 1
e 2 noaaeeyo IAeI ioia/aeinue oaaee/aiea ?I a?iioeaeueiiai nae?aoa.
Eiioeaio?aoeey io?aieaeacu a 1 noaaeee AAN nieaeaeanue a 2,4 ?aca, a ai
2 — a 5 ?ac. Auyaeaiiua ia?ooaiey ooieoeeiiaeueiie aeoeaiinoe AI
oa?aeoa?eciaaeenue nieaeaieai oaiiiaia eo aaeaacee e noaeeo,
oiaiueoaieai /enea eeaoie, o/anoaothueo a oaaioeeoica e nieaeaieai eo
oaaioeeoa?iie aeoeaiinoe ii ioiioaieth e /anoeoeai eaoaena.

Aoii?aeueiua oaeoi?u eiioiiie caueou i?aaiia aeuoaiey iaoiaeeeenue a
ninoiyiee ioiineoaeueiiai iai?yaeaiey — iaaethaeaeinue aeinoiaa?iia
iiauoaiea eiioeaio?aoeee IgG e nieaeaiea SIgA.

A iaaethaeaieyo, aaea i?iaiaeeeanue i?iaeeaiiay eneonnoaaiiay
aaioeeyoeey eaaeeo ioia/aeinue aeinoiaa?iia nieaeaiea niaea?aeaiey a
a?iioeaeueiii nae?aoa SIgA e IgG e iiyaeaiea IgM, /oi nii?iaiaeaeaeinue
?acaeoeai e i?ia?anne?iaaieai ainiaeeoaeueii-iaaiieoaeueiuo i?ioeannia a
i?aaiao aeuoaiey.

Aeeooa?aioee?iaaiiay E?O no?ieeanue n o/aoii noaaeee AAN, aeaea
yiaeia?iioeoa e noaiaie ia?ooaiee a EAeN. Ono?aiaiea a?iioeaeueiie
iano?oeoeee inouanoaeyeinue i?e iiiiue a?iioineiiee, eiaaeyoeeiiiie
oa?aiee, o?aino?aoaaeueiuo einoeeeyoeee e naiaoeeae /a?ac
eiooaaoeeiiioth o?oaeo. A ea/anoaa aaciaie eaaaaeiie aeeaeeinoe
eniieueciaaee 0,9% ?anoai? NaNl n ei??aae?iaaiiui ?I 6,0-7,0.A ninoaa
?anoai?ia aeey naiaoeee, eiaaeyoeee e einoeeeyoeee aeeth/aee eacieaai,
aaeanei?aei e aoeaoeeoeenoaei. I?e i?iaaaeaiee i?iaeeaiiie eneonnoaaiiay
aaioeeyoeey eaaeeo E?O aeiiieiyee aioo?eaaiiui aaaaeaieai
iaioieneoeeeeia.

N?aaieoaeueiue aiaeec aeeyiey o?aaeeoeeiiiie e aeeooa?aioee?iaaiiie E?O
iieacae, /oi iineaaeiyy niinianoaiaaea aieaa iieiiio e aieaa auno?iio
ainnoaiiaeaieth iniiaiuo caaiueaa EAeN.

Ai 2 a?oiia aieueiuo ia 2 e 3 yoaiao enneaaeiaaiey ?I a?iioeaeueiiai
nae?aoa ii?iaeeciaaeny, iieacaoaee ianiaoeeoe/aneeo iaoaieciia ianoiie
caueou i?aaiia aeuoaiey auee aeinoiaa?ii aeeaea e eiio?ieueiui
aaee/eiai, /ai aiaeiae/iua iieacaoaee a 1 a?oiia, ioia/aeinue
aeaoe?aoiia nieaeaiea aunaaaaiinoe ec OAAe iaoiaaiiie e
oneiaii-iaoiaaiiie iee?ioei?u

A oi aea a?aiy, iaoiaeu aeeooa?aioee?iaaiiie E?O ia ieacuaaee
au?aaeaiiiai iieiaeeoaeueiiai aeeyiey ia aoii?aeueiia caaii EAeN.
Ieacaeinue, /oi ia anao yoaiao E?O aeinoiaa?iiai eciaiaiey niaea?aeaiey
SIgA a a?iioeaeueiii nae?aoa ioia/aii ia auei a iaaeo a?oiiao.
Niaea?aeaiea IgG ia 2 e 3 yoaiao enneaaeiaaiey o aieueiuo 2 a?oiiu auei
aeinoiaa?ii auoa /ai o aieueiuo 1 a?oiiu.

I?aaeeiaeaiiua iaoiaeu ea/aiey iicaieytho nieceoue iauoth eaoaeueiinoue
i?e AAN ia 6,25%, a eaoaeueiinoue i?e eneonnoaaiiie aaioeeyoeee eaaeeo
ia 7,5%.

Eeth/aaua neiaa: a?iioianoiaoe/aneee noaoon, eioaineaiay ?anie?aoi?iay
oa?aiey, eiioieoao aeuoaoaeueiie nenoaiu.

ANNOTATION

Satsuta S.V. Differentiated intensive respiratory therapy and it
influence to an antiinfectious guard of organs of breath at the patients
with status asthmaticus. — Manuscript.

Thesis on competition of a scientific degree of the candidate of
medical sciences on a speciality 14.01.30. — anaesthesiology and
intensive care. — Dnepropetrovsk State Medical Academy, Dnepropetrovsk,
1999.

The thesis is devoted to actual problems of intensive respiratory
therapy (IRT) of the status asthmaticus. In the work is shown, that
traditional intensive respiratory therapy does not restore broken
immunity of a respiratory system (IRS) at these patients.

The concept of differentiated application of methods IRT in an
assotiation from a stage of acute respiratory insufficiency and
violations in IRS has received further development. The modified
technique of treatment of the patients with status asthmaticus has been
proposed. It promotes practically full restoring of unspecific links of
IRS.

The offered methods of treatment allow to reduce common mortality for
want of status asthmaticus by 6,25 %, and mortality for want of
artificial ventilation easy on 7,5%.

Key words: the status asthmaticus, intensive respiratory therapy,
immunity of a respiratory system.

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