?INOEOOO IAAe?AO???, AEOOA?NOAA OA A?IAEIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

Aeueii?ia Oaoyia Ieeiea?aia

OAeE 618.39 – 021.3:616.155.25 – 097

CAE*IA IAAEIIOOAAIIss AAA?OIINO?

? AIOEOINOIE?I?AeIEE NEIAe?II

14.01.01. – aeooa?noai ? a?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioa aeeiiaia a Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

?i. I.Ai?ueeiai IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio:

*aeea Aieiaeeie? Ee?eeiae/ aeieoi? iaaee/ieo iaoe, i?ioani?, caneoaeaiee
ae?y/iaaeeoeeie oa oaoi?ee Oe?a?ie, caa?aeoaa/ eaoaae?e aeooa?noaa,
a?iaeieia?? oa ia?eiaoieia?? Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?i. I.Ai?ueeiai IIC Oe?a?ie.

Io?oe?ei? iiiiiaioe:

Noaiaie?anueea Aaeeia Einoyioei?aia aeieoi? iaaee/ieo iaoe,
i?ioani?, /eai-ei?aniiiaeaio IAI ? AII Oe?a?ie, i?ioani? eaoaae?e
aeooa?noaa ? a?iaeieia?? ?1 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.
I.I. Aiaiiieueoey IIC Oe?a?ie (i. Ee?a)

Eaoo Noai?neaa Na?a?eiae/ aeieoi? iaaee/ieo iaoe, i?ioani?,
caa?aeoaa/ eaoaae?e aeooa?noaa ? a?iaeieia?? ?1 Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie (i.Ee?a);

E?nyieE Ieeiea ?aaiiae/ aeieoi? iaaee/ieo iaoe, i?ioani?,
caa?aeoth/ee a?aeae?eii iae?i?ioiieia?? ?inoeoooo iae?io??o?a?? AII
Oe?a?ie (i. Ee?a)

I?ia?aeia onoaiiaa:

Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie,
eaoaae?a aeooa?noaa oa a?iaeieia??

Caoeno a?aeaoaeaoueny «14» na?iiy 1999 ?ieo i 13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee ?c caoenoo aeena?oaoe?e ia caeiaoooy
iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeueiinoyie
«Iaae?ao??y», «Aeooa?noai ? a?iaeieia?y» (Ae 26.553.01) i?e ?inoeooo?
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i.Ee?a, aoe.
Iaio?euenueeiai, 8)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo iaae?ao???,
aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i.Ee?a, aoe.
Iaio?euenueeiai, 8)

Aaoi?aoa?ao ?ic?neaiee 8 eeiiy 1999 ?ieo

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
E.A.Eaaoi?ia

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Iaaeiiooaaiiy aaa?oiino? ? iaei??th c aeooaeueieo
i?iaeai no/aniiai aeooa?noaa /a?ac eiai i?yiee ca’ycie c ia?eiaoaeueiith
caoai?thaai?noth oa nia?oi?noth ? iio?aao? oaaaeiiai aea/aiiy aeey
i?io?eae-oeee naii/eiieo aai?o?a, ia?aae/anieo iieia?a oa ia?iaeaeaiiy
iaeiaaaiieo ae?oae. *anoioa oeueiai oneeaaeiaiiy caeeoa?oueny
noaa?eueiith i?ioyaii aaaaoueio ?ie?a ? neeaaea? 15-25 % an?o aaaeaieo
aaa?oiinoae. Aeecueei 25 % aeiaaee?a ia-aeiiooaaiue neeaaea? cae/iee
aeeeaeaiue, yeei aaa?oi?noue ia?a?eaa?oueny ia ? o?eiano?? ca oeiii
ia?icaeiooi? aaa?oiino? (Eoiaie A.I. oa ?i., 1999; Eaiae?ia I.I., 1999;
A?iiuei A.E., 1997; Neaeaeueieeiaa A. I., 1996).

O?aaeeoe?eia eiiieaenia ianoaaeaiiy, ui aeeth/a? aeine?aeaeaiiy
o?iii-nii, ai?iiiaeueiiai oiio iaoa??, ioe?ieo iaoi/ieo oa
oea?a?eaeueieo ii?o-oaiue, i?e?iaaeoa??ieia?? aai?oaeueiiai o?aeoo
aeicaieythoue ooi/ieoe i?e/eio iaaeiiooaaiiy ia a?eueoa, i?ae o 60 % ia?
(Ianiiia A.E. e ae?., 1998; Iaeaoea-?ey A.Ae. e ae?., 1993).

Ao?ieia?/i? oaeoi?e a?eueoino? oaoaeueieo ao?ao caeeoathoueny
iaa?aei-ieie oa oa?aeoa?ecothoueny ye ?ae?iiaoe/i?. A inoaii?e /an
?ae?iiaoe/ia iaae-iiooaaiiy ?yae a?o/eciyieo oa ca?oa?aeieo aaoi??a
iia’ycothoue c iayai?noth o ae?iie aooi?ioiiiai noaio, eio?ee ee?i?/ii
ia i?iyaey?oueny, ? iaoe??ioee ii-/oaathoueny oe?eeii caei?iaeie.
Iaeiae, c ianoaiiyi aaa?oiino? eiaeia aooi-?ioiia caoai?thaaiiy ?c noaio
?ai?n?? ia?aoiaeeoue a caaino?aiiy, oeo? aooi-aioeo?e oa ?o aa?an?y
c?inoathoue, ianoa? ia?a?eaaiiy aaa?oiino?. A 1986 ?ioe? aiae?enuee?
aeine?aeieee iienaee neiioiiieiiieaen, iacaaiee ieie ye
aioe-oinoie?i?aeiee neiae?ii (AON), iniiaieie i?iyaaie yeiai ?:
?ai?iaeoeoeai? ao?aoe aoaeue-yeiai no?ieo aanoaoe??, o?iiaice ??cii?
eieae?caoe??, o?iiaioeeoi-iai?y, iayai?noue a e?ia? niaoeeo?/ieo
aioeoinoie?i?aeieo aioeo?e (AOEA). *anoioa AON o iaoe??ioie c
ia?eiaoaeueieie ao?aoaie neeaaea? ca aeaieie ??c-ieo aaoi??a
(?iaeeianueea I.I., 1998; Iiiiia?aaa E.A., 1997; Hughes G.R.V., Harris
E. N., Gharavi A. E., 1986) a?ae 27 aei 41 %. I?ioa, ao?ieia?y oa
iaoiaaiac oeueiai caoai?thaaiiy aei oaia??oiueiai /ano ua ia aea/ai? aei
e?ioey. Iaoeiaee oa i?aeoe/iee ?ioa?an aeeeeea? aea/aiiy iniaeeainoae
aaia?aoeaii? ooie-oe??, ia?aa?a aaa?oiino? e iieia?a, a oaeiae noai
iiaiia?iaeaeaieo o oe??? a?oie ae?iie. Aeai? e?oa?aoo?e a oeueiio
iai?yi? ia/eneaii? oa noia?a/i?.

Ia aeine?aeaeaii ieoaiiy i?i aieea nioe?aeueii-aeieia?/ieo oaeoi??a ye
ni?eyoeeaeo /eiiee?a aeieeiaiiy ? ?icaeoeo AON /a?ac iioeiaeaeaiiy
?ioi-ii? nenoaie i?aai?cio. Ia aena?oeaii oae? i?iaeaie, ye e?eoa???
i?ieiiaaoe?? oa iniaeeaino? oa?ai?? a ? o?eiano?? aaa?oiino? i?e
?aoeeaeeaoth/?e caa?ic? ia-?a?eaaiiy aaa?oiino?, ?aoe?iiaeuei? niiniae
?ic?iaeaeaiiy, ioe?iea noaio caei-?ia’y iiaiia?iaeaeaiiai oa iaoiaee
ei?aeoe?? aeyaeaieo ii?ooaiue. Iaia? aea-ieo i?i ineoiaiioe?eiee noai
iaoe??ioie c AON a ia??iae ieaioaaiiy aaa?o-iino?, a oaeiae a?aenooiy
/?oea i?ia?aia ineoioa?aiaaoe/ii? ?aaa?e?oaoe??. Iniaeeai? oaaae
caneoaiao? i?iaeaia aca?iica’yceo ineoiaiioe?eiiai noaoo-no c
ai?iiiaeueiith oa ?ioiiith nenoaiaie ? ?ieue o?ii?/iiai no?ano a
iaoiaa-iac? aeieeiaiiy aooi?ioiieo ii?ooaiue ye i?e/eie ia?eiaoaeueieo
ao?ao i?e AON.

Aeooaeueieie aei oeueiai /ano caeeoathoueny oae? ieoaiiy, ye
ae?aaiinoeea oa e?eoaaiiy AON iica ? i?ae /an aaa?oiino?, iaoiaee
i?iaiicoaaiiy e eiio?i-eth ca aoaeoeai?noth i?ecia/aii? oa?ai??,
i?io?eaeoeea oneeaaeiaiue iieiaiai-ai aeoo ? ?aoe?iiaeueia ?ic?iaeaeaiiy
oeueiai eiioeiaaioo ae?iie, ?ic?iaea i?ei-oeei?a iioeiaeueieo
e?eoaaeueii-i?io?eaeoe/ieo caoiae?a c iaoith cieaeaiiy ia?eiaoaeueii?
caoai?thaaiino? oa nia?oiino?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Ia?aiee
iai?yiie aeine?aeaeaiiy o?nii iia’ycaiee c ieaiii iaoeiai-aeine?aeieo
?ia?o Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.
Ai?ueeiai oa iaoeiai-aeine?aeiiai ?inoeoooo iaaee/ieo i?iaeai n?i’?
(oaia “Aacia/ia iaoa?einoai a?ae caie?aeiaiiy aei ia?iaeaeaiiy”, ?
aea?ae?a?no?aoe?? 0197V002121).

Iaoa ?iaioe. ?ic?iaea iaoeiai-iaa?oioiaaieo noai ae?aaiinoeee,
e?eoaaiiy, i?io?eaeoeee oa i?aeaioiaee caieaiiaaii? aaa?oiino? o ae?iie
c? cae/iei iaaeiiooaaiiyi aaa?oiino? (CIA) i?e AON aeey cieaeaiiy
/anoioe ia?eiaoaeueieo ao?ao.

Caaea/? aeine?aeaeaiiy.

I?iaanoe ?ao?iniaeoeaiee ee?i?ei-noaoenoe/iee aiae?c ia?aa?ao
aa-a?oiino?, iieia?a, /anoioe ia?eiaoaeueieo ao?ao o ae?iie c? CIA,
iaoiiaeaiei AON.

Aea/eoe nioe?ieia?/i? oaeoi?e a a?oiao aaa?oieo ae?iie, ui oai??thoue ia
CIA aeey anoaiiaeaiiy ai?aeai?ieia?/ieo i?e/ei iaaeiiooaaiiy aaa?oiin-o?
a Aeiiaoeueeiio ?aa?ii?.

?ic?iaeoe aeey i?aeoe/iiai aeooa?noaa oa canoinoaaoe iaoiaee
ae?aa-iinoeee oa i?eioeeie ?aaa?e?oaoe?? AON ye iaei??? c i?e/ei
?ae?iiaoe/iiai iaaeiiooaaiiy aaa?oiino?, i?iaanoe
e?eoaaeueii-i?io?eaeoe/i? caoiaee ye ia noaae?? ieaioaaiiy aaa?oiino?,
oae ? c ?? ianoaiiyi.

C’ynoaaoe iniaeeaino? ?ioiiiai noaoono, nainea?e?caoe?? aei oaoaeueieo
aioeaai?a, iieacieee nenoaie aiiainoaco iica oa i?ae /an aaa?oiino? oa
?o aca?-iica’ycie c aaeaioeaieie ? noa?i?aeieie ai?iiiaie, iaae?aoi?aie
no?ano a ca-eaaeiino? a?ae oace iaino?oaeueiiai oeeeeo oa no?ie?a
aanoaoe??.

Aea/eoe ineoiaiioe?eiee noaoon iaoe??ioie c? CIA i?e AON oa ia oe?e
iniia? ?ic?iaeoe niaoe?aeueio i?ia?aio ineoioa?aiaaoe/ii? ?aa?e?oaoe??
iiae-?oaeiuei? ia?e a ia??iaee ieaioaaiiy aaa?oiino? oa ?? ianoaiiy.

Aeyaeoe iniaeeaino? noaio oaoiieaoeaioa?iiai eiiieaeno aaa?oieo c AON oa
?ic?iaeoe e?eoa??? i?iaiicoaaiiy eiai iaaeinoaoiino? oa aoaeoeaii-no?
e?eoaaiiy.

Ae?iaeoe oaeoeeo aaaeaiiy aaa?oiino? oa iieia?a, ?aoe?iiaeueii?
aeiiiei-aiai? i?aeaioiaee iaoe??ioie c AON ia i?aenoaa? aeyaeaieo
oneeaaeiaiue aaa?oii-no? ? iieia?a ca oiiae eiio?ieth ai?iiiaeueieo,
?ioiieia?/ieo, a?io?i?/ieo iieaciee?a oa ooieoe?iiaeueieo
aeine?aeaeaiue.

Cae?enieoe eiiieaenia ianoaaeaiiy iiaiia?iaeaeaieo o ?aiiueiio oa
i?c-iueiio iaiiaoaeueiiio ia??iaeao, aeeth/ath/e aea/aiiy ?ioiiiai
noaoono oa ineoiniiaoe/iiai ?icaeoeo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. O ?iaio? aia?oa ia no/an-iiio
iaoiaee/iiio ??ai? ?ic?iaeaii iieiaeaiiy aaaeeeai? iaaeeei-nioe?aeueii?
i?iaeaie aaa?oiino? ? iieia?a o ae?iie c ?ae?iiaoe/iei iaaeiiooaaiiyi c
ae-eeaaeaiiyi ee?i?ei-oai?aoe/ieo aniaeo?a aeieeiaiiy oa ?icaeoeo AON,
eiai aieeao ia ?ai?iaeoeoeaio oa ae?oi?iaeio ooieoe?th ae?iie, a oaeiae
ia noai caei-?ia’y ae?oae:

Anoaiiaeaii oa?aeoa?i? iniaeeaino? ?ioiiiai noaoono, nainea?e?caoe?? aei
oaoaeueieo aioeaai?a, iieacieee nenoaie aiiainoaco iica oa i?ae /an
aaa?o-iino? oa ?o aca?iica’ycie c aaeaioeaieie ? noa?i?aeieie ai?iiiaie,
iaae?aoi-?aie no?ano a caeaaeiino? a?ae oace iaino?oaeueiiai oeeeeo,
no?ieo aanoaoe?? ? ia oe?e i?aenoaa? ?ic?iaeaii eiioeaioe?th aeieeiaiiy
oa ?icaeoeo AON.

Aecia/aii e iaa?oioiaaii /eiieee, ui aieeaathoue ia iaaeiiooaaiiy
aaa?oiino? o iaoe??ioie c AON, ? ?ic?iaeaii niin?a i?io?eaeoeee
iaaeiioo-aaiiy aaa?oiino? ia aoai? ieaioaaiiy, ui aeeth/a? iaoiae
aoa?aioii? oa?ai?? (cayaea ? 98062877, ??oaiiy i?i aeaea/o iaoaioo
Oe?a?ie ia aeiao?ae a?ae 26.11.98).

Noai?aii niin?a e?eoaaiiy iaaeiiooaaiiy aaa?oiino? i?e AON, ui aeeth/a?
canoinoaaiiy aoa?aioieo iaoiae?a c ianooiiith ei?aeoe??th ?ioiiiai
aiiainoaco (a.n. N?N? ? 1733002 iioae. 15.01.92 oa cayaea ? 97126306,
??-oaiiy i?i aeaea/o iaoaioo Oe?a?ie ia aeiao?ae a?ae 28.10.98).

?ic?iaeaii oa canoiniaaii i?ia?aio e?eoaaiiy oa i?aeaioiaee iaoe??ioie c
AON aei iieia?a, ui aeeth/a? iie?ioaiiy e?iaiia?ao, ei?aeoe?th
aaiinoac?ieia?/ieo oa ?ioiieia?/ieo ii?ooaiue, a oaeiae
ineoioa?aiaaoe/io ?aaa?e?oaoe?th (iaoaio Oe?a?ie ia aeiao?ae ? 25666,
iioae. 30.10.98).

?ic?iaeaii eiii’thoa?eciaaio i?ia?aio ae?aaiinoeee ? i?iaiicoaaiiy
?acoeueoaoo aaa?oiino? oa iieia?a o iaoe??ioie c AON ia iniia? aea/aiiy
oa?ae-oa?o ii?ooaiue a nenoai? iaoe-ieaoeaioa-ie?ae (cayaea ? 98063394,
??oaiiy i?i aeaea/o iaoaioo Oe?a?ie ia aeiao?ae a?ae 26.11.98).

I?iaaaeaii eiiieaenia ianoaaeaiiy ae?oae, yeeo ia?iaeeee iaoa?? c AON,
?ic?iaeaii ? cai?iiiiiaaii eiiieaenio i?ia?aio i?io?eaeoeee
one-eaaeiaiue a ?aiiueiio iaiiaoaeueiiio ia??iae?.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. ?aeiiaiaeiaaii ia-a?oioiaai?
e?eoa??? ae?aaiinoeee oa eeaneo?eaoe?? AON. Cai?iiiiiaaii nenoa-io
iiaoaiii? aeeniaina?ecaoe?? oa eiiieaenii? ?aaa?e?oaoe?? iaoe??ioie ia
noaae?? ieaioaaiiy aaa?oiino?. Ai?iaaaeaeaii nenoaio aaoiiaoeciaaii?
aeeoa?aioe?eii? ae?aaiinoeee iaaeiiooaaiiy aaa?oiino? o iaoe??ioie c
AON. ?aeiiaiaeiaaii eiiieaenio e?eoaaeueio i?ia?aio, ui canoiniao?oueny
i?ae /an aaa?oiino? iaoe?-?ioie c AON, aeeth/a? ?ai,- ?ioiiei?aeoe?th,
naeaeoeaiee ieaciaoa?ac, e?eo-aaiiy oaoiieaoeaioa?ii? iaaeinoaoiino?
(OII), ?aoa?aeaoe?? ieiaea oa caaacia-/o? ia?iaeaeaiiy caei?iai?
aeeoeie, caiaeeoue aei i?i?iaeueieo oneeaaeiaiiy o noa-i? ?iae?ee?. Ia
iniia? ?ic?iaeaii? iaoiaeeee aeeoa?aioe?eii? ae?aaiinoeee, eii-ieaeniiai
e?eoaaiiy oa i?io?eaeoeee iaaeiiooaaiiy aaa?oiino? o iaoe??ioie c? CIA
i?e AON iie?ioaii aaiiaeeiai?/i? i?ioeane a nenoai?
iaoe-ieaoeaioa-ie?ae, o?io?/io ? ai?iiiaeueio ooieoe?? ieaoeaioe, ui
cieceei /anoioo aioo??o-iueioo?iaii? a?iien?? ieiaea oa caaacia/eei
ii?iaeueiee ?icaeoie aeeoeie.

Ai?iaaaeaeaiiy. Oai?aoe/i? iieiaeaiiy ? i?aeoe/i? ?aeiiaiaeaoe??
aeei-?enoiaothoueny a ?iaio? ae?ii/?o eiinoeueoaoe?e, iieiaiaeo oa
a?iaeieia?/ieo a?aeae?eaiue i. Aeiiaoeueea e Aeiiaoeueei?,
Aei?i?iiao?ianueei? oa Iaeanueei? iaeanoae, Aeiiaoeueeiai aea?aeaaiiai
?aa?iiaeueiiai oeaio?o ioi?iie iaoa?einoaa oa aee-oeinoaa, Oe?a?inueeiai
IAe? iaaee/ieo i?iaeai n?i(?, a oaeiae canoiniaothoueny a o/aiaiio
i?ioean? ia eaoaae?? aeooa?noaa, a?iaeieia?? oa ia?eiaoieia?? OII
Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. I?iaaaeaii aeaoaeueiee ee?i?/iee aiae?c
iniaeeainoae ia?aa?ao aaa?oiino? ? iieia?a, noaio ieiae?a ?
iiaiia?iaeaeaieo o ae?iie c? CIA, i?e/eiith yeiai ? AON. ?ic?iaeaii
aeai?eoi ne?ei?iaiaiai ianoaaeaiiy iaoe??ioie c AON aei aaa?oiino? oa
i?ae /an ?? ia?aa?ao, aecia/aii e?eoa??? ioe?iee nooiaiy i?iyao o ieo
ineoiaiioe?eii? iai?oae (IAI), ai?ii-iaeueieo oa ?ioiieia?/ieo ci?i ? ia
oe?e i?aenoaa? iaa?oioiaaii iaoiaaiac ?ic-aeoeo cae/iiai aeeeaeiy.
Cai?iiiiiaaii iiaee i?aeo?ae aei ioe?iee ?ioiieia?/-iiai noaio,
aaiinoac?ieia?/ieo iieaciee?a, IAI oa ?o ei?aeoe?? i?ae /an ieaio-aaiiy
oa ia?aa?ao aaa?oiino?. ?ic?iaeaii ? iaa?oioiaaii iiaoaiiee eiiieaen
aeiiieiaiai? i?aeaioiaee aaa?oieo, ui iaee a aiaiiac? CIA oa ia?aaoaaee
i?ae aieeaii IAI ? iani?eyoeeaeo nioe?ieia?/ieo /eiiee?a. I?iaaaeaii
niinoa?a-aeaiiy ca noaiii aaa?oieo c AON a aeeiai?oe? ? aeeiiaii iniiaio
/anoeio i?aai?caoe?eieo i?aeoiae?a aei aeai?o iaoe??ioie, ?ic?iaee
aeai?eoio ianoa-aeaiiy, iaoith yeiai ? aeyaeaiiy AON. Aaoi? ?ic?iaea
iaoiaeeeo cae?eniaiiy aoa?aioieo iaoiae?a e?eoaaiiy – ieaciaoa?aco oa
ieaciini?aoe??. Iaa?oi-oiaaii iaoai?ci aieeao ia i?aai?ci oa
aoaeoeai?noue canoinoaaiiy ieaciaoa-?aco oa ieaciini?aoe?? i?e e?eoaaii?
oa i?io?eaeoeoe? AON oa eiai oneeaae-iaiue: OII, aioo??oiueioo?iaii?
a?iien?? oa a?iio?io?? ieiaea. ?ioa?i?aoiaaii iaea?aeai? ?acoeueoaoe,
c?iaeaii oai?aoe/i? aeniiaee ? ?ic?iaeaii i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ia O c’?cae?
aeooa??a-a?iaeieia?a Oe?a?ie (Iaeana, 1996); i?aeia?iaeieo: “World
Apheresis association 6-th International Congress Florence, Italy”
(Oei?aioe?y,1996) oa “World Conference The ovary: Regulation d?sfunction
and treatment, Marco Island, Florida, USA” (Marco Island, 1996),
Ni?euei?e oe?a?inueei-i?iaoeuee?e eiioa?aioe?? “No/ani? i?iaeaie
?ioaeoieia?? a aeooa?noa? oa a?iaeieia??” (Aeiiaoeuee, 1996), Ieaioi?
anioe?aoe?? aeooa??a-a?iaeieia?a Oe?a?ie “Iaaeii-ooaaiiy aaa?oiino?”
(*a?i?aoe?, 1997), O?? Eiia?an? ?a?iiaenueei? anioe?aoe??
aeooa??a-a?iaeieia?a, Aeai?y (1997, Eiiaiaaaai); Ieaioi? anioe?aoe??
aeooa??a-a?iaeieia?a Oe?a?ie “Eana?nueeee ?icoei a no/aniiio aeooa?noa?”
(1998, ?a-iaoi??y), Can?aeaii? A/aii? ?aaee IAe? iaaee/ieo i?iaeai n?i’?
(Aeiiaoeuee, 1998).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 32 i?aoe?, c ieo: 1
iiii-a?ao?y, 23 noaoo?, 5 oac iaoeiaeo eiioa?aioe?e oa c(?cae?a. Ca
iaoa??aeaie ?iai-oe io?eiaii 1 aaoi?nueea na?aeioeoai N?N? ? 1733002,
“Niinia ea/aiey oa?i-cu i?a?uaaiey aa?aiaiiinoe”, 1992, oa 2 iaoaioe
Oe?a?ie ia aeiaoiaee ?25666A, “Niin?a i?aeaioiaee aaa?oii? aei iieia?a”,
1999; ? 25676A, “Niin?a aaaeaiiy iieia?a i?e aeeneii?aeeiiaai?e
iieiaia?e ae?yeueiino?”, 1999.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 305 a?eooao
iaoeiiieniiai oaenoo, i?i?ethno?iaaia 21 ?enoieii ? 50 oaaeeoeyie.
Neea-aea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, 6 ?icae?e?a aeanieo
aeine?aeaeaiue, caeeth-/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e,
nieneo e?oa?aoo?e c 350 aeaea?ae, ui aeeth/a? 132 a?o/eciyiiai oa 218
ca?oa?aeieo aaoi??a.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeey ae??oaiiy iinoaaeaieo
caaaeaiue i?iaaaeaii nioe?ieia?/ia oa ee?i?ei-noaoenoe/ia ne?ei?iaiaa
ianoa-aeaiiy 1127 iaoe??ioie, ui i?iaeeaathoue a ?icaeiooeo i?iieneiaeo
?aa?iiao Aeiiaoeueei? iaeano? c oa?aeoa?iei aeey no/aniiai ?icaeoeo
noni?euenoaa eiii-eaenii nioe?aeueii-aeiiii?/ieo, aeieia?/ieo i?iaeai,
aenieith IAI, ui aieeaathoue ia noai o?ce/iiai oa ineo?/iiai caei?ia’y
ae?iie o ?ai?iaeoeoea-iiio ia??iae?. Ia ia?oiio aoai? aoei i?iaaaeaii
?ao?iniaeoeaiee aiae?c ia-?aa?ao aaa?oiino?, iieia?a, i?neyiieiaiaiai
ia??iaeo oa noaio iiaiia?iaeaeaieo ca aeaieie ?noi??e iieia?a
iaoe??ioie, ui iaee a aiaiiac? CIA (750 ae?iie). Aoei aeyaeaii, ui o 280
(37,3%) c ieo i?e/eio ?ai?iaeoeoeaieo ao?ao anoa-iiaeoe ia aaeaeinue.
Oe? iaoe??ioee aoee acyo? ia aeeniaina?iee iae?e a Aeiiaoeue-eiio
aea?aeaaiiio ?aa?iiaeueiiio oeaio?? ioi?iie iaoa?einoaa oa aeeoeinoaa,
aea ?i aoei i?iaaaeaii eiiieaenia iiaeeaeaia ianoaaeaiiy c iaoith
anoaiia-eaiiy ae?enieo i?e/ei naii/eiiiai ia?a?eaaiiy aaa?oiino?. Aeey
iiaeeaeaii-ai ianoaaeaiiy ?ioiiiai, ai?iiiaeueiiai, aaiinoac?ieia?/iiai
oa ineoiaii-oe?eiiai noaio aoei a?ae?a?aii 140 ae?iie c iiceoeaiith
?aaeoe??th ia aia/aei-aee aioeeiaaoeyio (AA). Ianoaaeaiiy oa e?eoaaiiy
oeeo iaoe??ioie i?iaiaeeee-ny iica ? i?ae /an aaa?oiino?. A caeaaeiino?
a?ae niiniao ?aaa?e?oaoe??, ui canoini-aoaaeanue, aiie aoee ?icae?eai?
ia 2 a?oie. A?oie aeiae?aeenue ca aeia?ia?eueiei ne?iei aeai?ii. ? a?oio
neeaee 80 iaoe??ioie, eio?ei aoea i?iaaaeaia ?aaa?-e?oaoe?y aei ianoaiiy
ianooiii? aaa?oiino?. Eiiieaen e?eoaaeueieo caoiae?a aeeth/aa
?ic?iaeaiee niin?a i?aeaioiaee aei aaa?oiino? (cayaea ia aeiao?ae
?98062877, ??oaiiy i?i aeaea/o iaoaioo Oe?a?ie a?ae 26.11.98). Iaaeae?
80 ia-oe??ioeai ? a?oie i?ney ianoaiiy aaa?oiino? aoei cae?eniaii
e?eoaaiiy AON (cayaea ia aeiao?ae ? 97126306, ??oaiiy i?i aeaea/o
iaoaioo Oe?a?ie a?ae 28.10.98, iaoaio Oe?a?ie ? 25666, iioae. 30.10.98)
ca ?ic?iaeaiith i?ia?a-iith, ui aeeth/aea ei?aeoe?th oneeaaeiaiue
ia?aa?ao aaa?oiino?, oaeoeeo aaaeaiiy oa aea?? iaoiaeo ?ic?iaeaeaiiy, a
oaeiae ee?i?/ia oa eaai?aoi?ia ianoaaeaiiy iiaiia?iaeaeaieo (78
iaiiaeyo), ui ia?iaeeeenue a?ae oeeo iaoa??a, oa e?eoaaiiy ae?oae o ?ac?
aeieeiaiiy oneeaaeiaiue a ?aiiueiio iaiiaoaeueiiio ia??iae?. ?? a?oio
neeaee 60 iaaaa?oieo ae?iie, yeeo aoei ianoaaeaii o?aaeeoe?eiei
niini-aii. Cai?iiiiiaaia i?ia?aia ?aa?e?oaoe?? ca ?ic?iaeaiith
iaoiaeeeith aei oeeo iaoe??ioie ia canoiniaoaaeanue, ianoaiiy aaa?oiino?
ia ieaioaaeinue ? aoei niiioaiiei. I?e iiya? oneeaaeiaiue ia?aa?ao
aaa?oiino? (a?eue, e?iaiiacaiiy oa ?i.) oeth a?oio ae?iie e?eoaaee oae,
ye o?aaeeoe?eii i?eeiyoi e?eoaaoe a nenoai? ioi?iie caei?ia’y caa?ico
ia?a?eaaiiy aaa?oiino? (Neaeaeueieeiaa A.I., 1986). Ianoaaeaiiy
iiaiia?iaeaeaieo (36 ae?oae) a?ae iaoa??a ?? a?oie aoei oei naiei, ui ?
ae?oae a?ae iaoa??a ? a?oie. Aiaeia?/i? aeine?aeaeaiiy i?iaaaeaii a
a?oi? ni-iaoe/ii caei?iaeo ae?iie (iaaaa?oieo – 20, aaa?oieo – 30) oa
?oi?o iiaiia?iae-aeaieo ae?oae (30 iaiiaeyo).

I?e aea/aii? nioe?aeueii-ineoieia?/iiai ooieoe?iioaaiiy iniaenoino?
ioe?ithaaee iniaenoo oa ?aaeoeaio o?eaiaei?noue a aaeao ii oeae?
?.Ae.Ni?eaa?-aa?a a iiaeeo?eaoe?? TH.E.Oai?ia (1976). Nooi?iue IAI
aecia/aee ca iaoiaeii eieuei?iaiai aeai?o (oano Ethoa?a) c e?euee?nieie
iieacieeaie (eiao?oe??ioe Aieueiaoa?a oa Oeiioa). Aaaaoaoeaio eaieo oa
noai aaeaioeaieo ?aaeoe?e ioe?-ithaaee ca iaoiaeii A.I.Aaeia (1981) c
ia/eneaiiyi ?iaeaeno Ea?aei. Aeaeo-?e/io aeoeai?noue iiceo ioe?ithaaee
ca aeaeo?iaioeaoaeia?aiith (AAA) a noai? o?c?ieia?/iiai niieith oa ia
oe? ooieoe?iiaeueieo iaaaioaaeaiue o iaaaa?oieo, aaa?oieo (?, ??, ???
o?eiano?) aei oa i?ney e?eoaaiiy. Aeine?aeaeaiiy ai?iiiaeue-iiai noaoono
aeeiiaii ca iaoiaeeeith ?aae?i?ioiieia?/iiai aiae?co. Aeioai?i,
aae?aiae?i, ii?aae?aiae?i a na/? aecia/aee ca iaoiaeii A.O.Iaoe?ii? oa
O.A.?ioiaiiai?. Iieacieee ai?iii?a oaoiieaoeaioa?iiai eiiieaeno oa
a?ee?a aaa?oiino? – aeueoa2-i?e?iaeiaoe?i oa?oeeueiino? (AIAO),
o?ioiaeanoe/iee aaoa1-aeiaoe?i (OAA), ieaoeaioa?iee
aeueoa1-i?e?iaeiaoe?i (IAIA), – aecia-/aee ?ioiioa?iaioiei niiniaii. I?e
aeine?aeaeaii? ?ioiiiai noaoono aecia-/aee ??aaiue ai?noo eaeeioeeo?a
ca aeiiiiiaith eaia?e Ai?y?aa (Aa?ai/ai-ei A.A., 1991).
Aeeoa?aioe?eiee ?ic?aooiie eaeeioeeoa?ii? oi?ioee i?iai-aeeee
oi?o?eiaaiei iaoiaeii ii?oieia?/iiai aeine?aeaeaiiy oi?iaieo aeaia-o?a
e?ia? c i?eaiooaaiiyi aaiaoieia?/iiai iacea (Aa?ai/aiei A. A., 1991).
Iieacieee aeni?an?? iiiiioeeaa?aie e?ia? iieaeoe CD3, CD4, CD8, CD16,
CD22 aecia/aee ca aeiiiiiaith a?aeiia?aeieo iiiieeiiaeueieo aioeo?e a
?aaeoe?? i?yii? ethi?ianoeaioe??. ??aaiue ?ioiieo eiiieaen?a aecia/aee
ca iaoiaeii TH.A.A?eiaae/a, A.I.Aeouei?iaa, 1981. Oaaioeeoa?ia
aeoeai?noue iaeo?io?e?a ia?aa??yeanue /a?ac oano c i?o?inei?i
oao?acie??i (A.I.Park, 1968). Ai?no ?io-iiaeiaoe?i?a G, A, M aecia/aee
niiniaii ?aae?aeueii? ?ioiiaeeooc?? (G.Man-chini et al., 1965).
Eiioeaio?aoe?y IgE anoaiiaethaaeanue ca aeiiiiiaith ?ioii-oa?iaioiiai
iaoiaeo. ??aaiue aioeo?e aei oinoie?i?ae?a eean?a IgG oa IgM ae-cia/aee
ca aeiiiiiaith ?ioiioa?iaioieo iaai??a ae?iaieoeoaa «Rad» (?in?y).
Ooieoe?iiaeueio aeoeai?noue O-ee?oeiiiai ?ioi?oaoo aecia/aee ca
Hangerford (1959, 1960), ?ioiieaeeie?c aei aioeaai?a eeoeiai? iaee/ee oa
noao?eieieo – ca O?aaee?iei (1975). Aaiie?oe/ia aeoeai?noue
eiiieaiaioo aecia/aeanue ca 50 % aaiie?co oi?o?eiaaiei iaoiaeii
(Aa?ai/aiei A. A., 1991).

Nainea?e?caoe?th aei oaoaeueieo aioeaai?a ieiaea (na?oea, eaaai?, ie?ee)
oa ieaoeaioe aecia/aee ca ?aaeoe??th aaeueioaaiiy i?a?aoe??? e?ioioeeo?a
oa cai?iiiiiaaiei iieacieeii eiiieaenii? nainea?e?caoe?? (IEN) aei
/ioe?ueio aioeaai?a (cayaea ia iao. Oe?a?ie ? 98063394, ??oaiiy i?i
aeaea/o iaoaioo a?ae 26.11.98), yeee ?ic?aoiaoaaee ca oi?ioeith:

aea n – /enei aioeaai?a, IMi – ?iaeaen i?a?aoe?? c aioeaaiii. I?e
cia/aii? IEN<0,15 eiinoaooaaee a?aenooi?noue nainea?e?caoe??. Ca eaai?aoi?ieie oanoaie aecia/aee aaiinoac?ieia?/i? iieacieee: eiioeaio?aoe?th o?a?eiiaaio (?ooaa?a, 1962), cia/aiiy eaie?iiaiai /ano, aeoe-aiaaiiai /anoeiaiai o?iiaiieanoeiiaiai /ano (A*O*), i?io?iia?iiaiai ?i-aeaeno (A.I.Aaeoaea oa ni?aaao., 1980). Iayai?noue AA a e?ia? aaa?oii? ia?aa?-?yee ca iaoiaeii Austen a iiaeeo?eaoe?? E.C.I?oaeieeiai? oa O.A.Naeeianueei? (1988). Ii?oieia?/i? oa a?noio?i?/i? aeine?aeaeaiiy ieaoeaioe i?iaiaeeee ca iaoiaeii Aai A?ciia. U?euei?noue ?ici?uaiiy noaeei a ieaoeaio? aecia/aee ia-oiaeii eaaae?ao?a Naeoeeiaa, a ieoiio aaao noaeei – iaoiaeii iie?a Aeaaie?aa. Noai ieiaea ioe?ithaaany ca aeiiiiiaith oeueo?acaoeiaiai aeine?aeaeaiiy (OCAe) ? ea?ae?ioieia?ao?? (EOA). ?ioa?i?aoaoe?th aeaieo cae?enithaaee ca iaoiaeii W.Fisher a iiaeeo?eaoe?? ?.I.Iaea?iaa c? ni?aaao. (1997). Noaoenoe/io ia?iaeo iaoa??ae?a i?iaiaeeee iaoiaeaie aa??aoe?eiiai, ei?aeyoe?eiiai ? e?eoa??aeueiiai aiae?c?a c aeei?enoaiiyi AII ?AI/PS/AT. ?acoeueoaoe aeanieo aeine?aeaeaiue oa ?o iaaiai?aiiy. I?iaaaeaia nioe?ieia?/ia oa ee?i?ei-ineoieia?/ia ne?ei?iaiaa ianoaaeaiiy 1127 iaoe??i-oie iieacaei, ui 750 c ieo iaee i?iaeaie c iaaeiiooaaiiyi aaa?oiino?. Aiae?c aeaieo aieao aaa?oieo ae?iie, ui ia?aaoaaee ia e?eoaaii? a Aeiiaoeue-eiio aea?aeaaiiio ?aa?iiaeueiiio oeaio?? ioi?iie iaoa?einoaa oa aeeoeinoaa c i?eaiaeo caa?ice ia?a?eaaiiy aaa?oiino? oa iaee a aiaiiac? 2 aai a?eueoa naii/eiieo aai?o?a, iieacaa, ui a ai?aeai?ieia?? iaaeiiooaaiiy i?ia?aeieie oaeoi?aie ?: iaaeeei-aaia?ao?/i? (86 %), iaaeeei-a?ieia?/i? (74 %), nioe?aeue-ii-aeiiii?/i? (31 %), aeaiia?aoi-aoi?/i? (12 %). Oe?aeeea? cae/ee (iae?iiy, aaeeaaiiy aeeiaieth oa ia?eioee?a) iaee i?noea a aeeoo? 44 % iaoe??ioie. I?e ee?i?/iiio ianoaaeaii? iaoe??ioie aeyaeaii, ui a?eueoa 50 % c ieo iathoue a?e ca 30 ?ie?a. Oea ? oa?aeoa?iith iciaeith iaoe??ioie c? CIA. Aiie oai??thoue oe?eei ?yaeii iaaeoa?a (4-5), na?aae yeeo ia?aaaaeathoue a??oni? oa aae-oa??aeuei? ?ioaeoe??. Anoaiiaeaii, ui o a?eueoino? ianoaaeaieo ae?iie iaa i?noea o?ii?/iee oiicee?o ??ciiai nooiaiy oyaeeino?, o 15 % c ieo aoei i?iaaaeaii oiiceeaeoii?th. Ianoaaeai? iaoe??ioee /anoi oai??ee ia a?iio?o, aino?? ?ani?-?aoi?i? a??oni? ?ioaeoe?? (A?A?), ?aaiaoeci, aea?a?th (?en.1). A??oni? aeeoy/? caoai?thaaiiy ia?aianee iaoe??ioee a 21 % aeiaaee?a. Iaoe??ioee c? CIA iaee a?ae 2 aei 6 o?ii?/ieo caoai?thaaiue caiaeueiiai oa?aeoa?o. ?ioith iae/ano?oith aeno?aaai?oaeueiith iaoieia??th aoee noaeeii? caoai?thaaiiy (19,3 %): iae?i-oee?eoeyoi?ia aeenoii?y (??cieo oei?a), i?a?aiue, aa?eeicia oai?iaa, ii?ooai-iy e?iaiia?ao a iiceo ooieoe?iiaeueiiai oa?aeoa?o. Na?aae a?iaeieia?/ieo ca-oai?thaaiue ia?aaaaeaee o?ii?/i? aaeiaeneoe, oeeoiiaaaeia??onia (OeIA), aa?-iaoe/ia oa o?iaai?oaeuei? ?ioaeoe?? (?en.2). Noiniaii iaino?oaeueii? ooieoe?? aeyaeaii, ui iaaeinoaoi?noue ethoa?iiai? oace oa a?ia?aiae?iaai?y cono??/aeenue o eiaeii? o?aouei? iaoe??ioee, ui ia a?ae??ciyei ?o a?ae ?ioeo iaoe??ioie c? CIA. Iaeiae, ia a?aei?io a?ae inoaii?o, ai?iiiaeueia ei?aeoe?y noaio aaa?oieo c AON oni?oo aeey aeiiooaaiiy aaa?oiino? ia iaea. Iaoe??ioee c AON iaee ae?ae ia-oyaeaiee aeooa?nueeee aiaiiac (?en.3). Noai iiaiia?iaeaeaieo oa?aeoa?eco-aaany aenieith /anoioith caoai?thaaiino? oa iaiiaoaeueii? nia?oiino? (?en.4). Ia?aa?a oaia??oiuei? aaa?oiino? ae?iie, ui ciaoiaeeeenue i?ae niinoa-?aaeaiiyi, caeaaeaa a?ae e?eoaaiiy ia aoai? ieaioaaiiy oa i?ae /an aaa?oiino?. *anoioa oneeaaeiaiue aaa?oiino? o iaoe??ioie ?? a?oie aoea a??ia?aeii aeua a ii??aiyii? c ? a?oiith. Oyaeeee nooi?iue OII aeyaeaii o iaoe??ioie c iani?eyoeeaei ?acoeueoa-oii ?icaeoeo aaa?oiino?. I?e iae?ineineii?/iiio aeine?aeaeaii? ieaoeaio, io-?eiaieo a?ae iaoe??ioie c AON, aeyaeaii, ui na?aaeiy iana ieaoeaioe i?e aei-iioai?e aaa?oiino? aei??aith? 485,1(20,6 a, ia’?i – 374,2(6,4 ni3, ieiua – 49,4(2,3 ni2, iaea?eueoee ae?aiao? – 16,5(0,3 ni, oiaueia ii oeaio?o ieaoeaioe – 1,8(0,2 ni, ii ia?eoa??? – 1,3(0,1 ni. Ne?ae a?aecia/eoe, ui aeine?aeaeai? ia?aiao?e nooo?ai ia a?ae??ciyeeny a?ae iiae?aieo a eiio?ieuei?e a?oi?. Iaeiae, a ieaoeaioao ae?iie c iayai?noth cao?eiee ?icaeoeo ieiaea (C?I), OII, a oaeiae i?e ia?aae/anieo iieiaao a?aei?/aeiny ??cea ciaioaiiy ?ici???a ? iane iea-oeaio: na?aaeiy iana neeaaeaea 246,2(19,4 a, ia’?i – 184,7(7,8 ni3, oiaueia ii oeaio?o ieaoeaioe – 0,8(0,1 ni, ii ia?eoa??? – 0,6(0,1ni. I?e i?e?ineii?/ii-io aeine?aeaeaii? ieaoeaio aoei aeyaeaii e?iaiaeeeae i?ae oi??aeueio (OI) ? aacaeueio (AI) ieanoeiee, a i?aeai?nyi? i?inoi?e, ?ao?iieaoeaioa?i? aaiaoi-ie, e?iaiaeeeae a oi??aeueio oa aii?aeueio iaieiiee, o?iiaic ? noace a noaee-iao na?aaei?o ai?nei, aaeee? e?iaiaeeeae a i?aeai?nyi? i?inoi?e. Aeeno?io?/-i? i?ioeane a ieaoeaioao i?iyaeeeny iayai?noth o?a?eii?aea, ina?aaeeiaei a?ae-eeaaeaiiyi aaiia, aaeeeeie ?ioa?eoaie a AI, ina?aaeeiaith ?io?eueo?aoe??th e?ioioeeoaie, noacaie a noaeeiao noiaao?iaeo ai?nei, caoaeaiiyi i?aeai?ny-iiai i?inoi?o, o?a?eii?aeiei ia?aooai?aiiyi no?iie e?ioeaaeo ai?nei, ?ic-oe?aiiyi noaeei na?aaei?o ? noiaao?iaeo ai?nei ?c noacaie, iayai?noth ?i-oa?eo?a, ae?eyieaie iae?ico OI. Iae?ic ? iae?ia?ic a?aei?/aeeny ia a?eueo?e /anoei? ieaoeaioe, aacaeueia iaia?aia o?ioiaeanoa aoea ia?a?ea/anoith, ii-aeaeoaee ?ic?eaaeany a ?acoeueoao? ??ceiai iaa?yeo no?iie. I?e a?noieia?/iiio aeine?aeaeaii? ieaoeaio a a?oa??yo oa noaeeiao ae??aiiai eae?a?o ciaeaeaii iaoi-eia?/i? ci?ie, ye? i?iyaeyeeny a aenoaeaoeaiii?ie?oa?aoeaiiio caiaeaii? ca oeiii aiaeiaaneoe?oo, a?aei?/aeiny ??cea caoaeaiiy i?ina?oo noaeei iaeaea aei u?eeiiiai. Iienai? aeua ii?ooaiiy e?iaiia?ao a iaoa?einuee?e /anoei? iea-oeaioe i?eaiaeeee aei a?aeeeaaeaiiy aaeeei? e?eueeino? nie? Na++ acaeiaae ia?aai-?iaeie i?ae eioeeaaeiiaie ieaoeaioe, a oaeiae iaaeiei ia?aeiieo ai?nei, ui ni?eyei neea?ico a?oa??e, ye? a?aee?eaathoueny a i?aeai?nyiee i?ino??. A ia-oa?einuee?e /anoei? ieaoeaioe a?aei?/aeeny ??cei ae?aaeai? aeeno?io?/i? ci?ie ee?oei, iaeiie/aiiy ae?eiaaio, aaeoie?caoe?y ee?oei, ae?eyiee ioei?aeiiai ia-a?yeo ? neiie/aiiy ieaciaoe/ieo ee?oei. Aeacai? ci?ie aeathoue i?aenoaao i?e-ionoeoe, ui aiie noaee iane?aeeii ?ioiieia?/ii? ?aaeoe?? i?ae i?aai?ciaie iaoa?? oa ieiaea ? ca nooiaiai ae?aaeaiino? aaea iineee aeaeiiiainiaaiee oa?aeoa?. I?e ii?oiiao?e/iiio aea/aii? noaeei ai?nei ieiaeiai? /anoeie ieaoeaio anoaiiaeaii cieaeaiiy a?aeiiniiai ia’?io i?e?ioee?eoeyoi?iiai ?on-ea o ii?iae?eue ?? a?oie a ii??aiyii? c ae?ieaie ? a?oie (na?aaeiy aonoeia noaeei a ? a?oi? – 0,34(0,08, a ?? a?oi? – 0,22(0,09). C ? o?eiano?o aaa?oiino? a?aecia/aee cieaeaiiy eiioeaio?aoe?? ai?iii?a oaoiieaoeaioa?iiai eiiieaeno: ieaoeaioa?iiai eaeoiaaio (IE), ano??ieo (A3), i?iaanoa?iio (I), oi??aeueiiai aiiaaeio?ii?io, ci?io eiioeaio?aoe?? ieaoeaioa?-ieo a?ee?a. Oe? ci?ie ia?aaeoaaee ee?i?/iei i?iyaai iaaeiiooaaiiy aaa?oiin-o?, iniaeeai a ?? ?aii? no?iee (oaae.1). I?e a?noieia?/iiio oa ii?oieia?/iiio aeine?aeaeaii? ieaoeaio ii?iae?eue ? a?oie oaeiae niinoa??aaeenue aeuacaaaeai? ci?ie, aea aiie iineee iaio ae?ac-iee oa?aeoa?, ?a?no?oaaeinue eiiiainiaaia ca?eueoaiiy i?e?ioee?eoeyoi?iiai ?onea ieaoeaio i?ae ae??th cai?iiiiiaaii? oa?ai??, ui caaacia/oaaei aiiainoac ieiaea oa ia?iaeaeaiiy aeiiioaieo (oa iaaeiiioaieo) aeeoo?caeaoieo ae?oae aac iciae a?iio?io??. I?e aeine?aeaeaii? ai?iiiaeueiiai noaoono iaoe??ioie c AON iica aaa?o-i?noth ae?aaeaieo iaoieia?/ieo ci?i ia aoei aeyaeaii. Iieacieee eiioeaio-?aoe?? ai?iii?a a?iio?ca, y?/iee?a, ueoiaeaeii? caeice, iaaeie?eiaee?a ia a?ae-??ciyeenue, ca aeeeth/aiiyi aae?aiiei?oeeio?iiiiai ai?iiio (AEOA), ei?oe-cieo (E) oa i?ieaeoeio, eiioeaio?aoe?? yeeo aoee aaea?/? i?aeaeuai? (p<0,05). Oe? ai?iiie a?aeiinyoue aei eaoaai??? ai?iii?a no?ano, yeee aeieeaa o iaoe??ioie c? CIA iayniiai aaiaco oa iaa o?ii?/iee o?eaaeee oa?aeoa?. C ianoaiiyi aa-a?oiino? a?aeaoaaeinue cia/ia i?aeaeuaiiy eiioeaio?aoe?? E, iniaeeai a II a?oi?, aea iaoe??ioee ia i?ieoee i?io?eaeoe/iiai e?eoaaiiy. O 20 % iaoe??ioie c AON niinoa??aaee ci?ie a ai?iiiaeueiiio aiiainoac?. I?e oeueiio aoei aeae?-eaii 3 iaea?eueo oa?aeoa?ieo oeie ai?iiiaeueieo ii?ooaiue: ? oei – aeao?oeeo I (10 % aeiaaee?a), ?? – ii?iaeueia ni?aa?aeiioaiiy I/A2 (81,5 % aeiaaee?a), ??? – aeao?oeeo ano?aae?ieo (A2) – 9,5 % niinoa?aaeaiue. Iaea?eueo ?ioi?iaoeaiei aeyaeany iieaciee I/A2, yeee oi/i?oa ca an? ?io? a?aeia?aaea? ci?ie a aeeia-i?oe? aaa?oiino?. Io?eiai? aeai? na?ae/aoue i?i oa, ui iniiaiith i?e/eiith ia?a-?eaaiiy aaa?oiino? o iaoe??ioie aoee ia ai?iiiaeuei? ii?ooaiiy, a iayai?noue AON. Iaeiae, o iaoe??ioie c aeyaeaieie ci?iaie iaiao?aeii ona-oaee i?iaiaee-oe ei?aeoe?th ai?iiiaeueiiai aeenaaeaino i?ae /an aaa?oiino? ?acii c iaoiaaia-oe/iei e?eoaaiiyi AON. I?e aea/aii? ineoiaiioe?eiiai noaio iaoe??ioie aeyaeaii, ui ua iica aaa?oi?noth o ae?iie a?oi aea/aiiy iaee i?noea o?eaiaeii-iaa?ioe/i? ?iceaaee, ye? ia?inoaee c ianoaiiyi aaa?oiino?, ine?eueee ae?iee ia aoee aiaaiai? a ?? ni?eyoeeaiio ?acoeueoao?, ai i?e/eio ia?a?eaaiiy iiia?aaeiuei? aaa?oiino? ia aoei anoaiiaeaii. Iaoe??ioee ?? a?oie, iaee a?eueo aenieee ??aaiue aeanii? oa neooaoeaii? o?eaiae, aioo??oiueiai iai?oaeaiiy oa aiioe?eii? ianoaa?eueiino?, i?ae iaoe??ioee ? a?oie (?en.5). Niinoa??aaany o?niee ei?aeyoe?eiee ca’ycie i?ae iieacieeii aeanii? o?eaiae oa iieacieeaie aiiainoaco iaoe??ioie c AON (oaae.2). I?e aeine?aeaeaii? a?iaeaeo?e/ii? aeoeaiino? iiceo aoee aeyaeai? ae-?aci? iciaee aeacaaeaioaoe??, aneiao??? aae aei ci?i ia?ieneciaeueiiai oa?aeoa?o, ye? ioe?ithaaeenue ye c?ea aaeaioaoe??. Niinoa??aaeanue i?yia ei?aeyoe?eia caeaae-i?noue (r = 0,84) i?ae nooiaiai IAI oa oa?aeoa?ii ci?i ia AAA. Iaoiaaiaoe/io iniiao oeeo ii?ooaiue neeaaeathoue ??ci? oi?ie aeac?ioaa?aoe?? ae?yeueiino? iania-oeeo?/ieo ?ioaa?aoeaieo nenoai iiceo, ia?o ca ana e?ia?ei-?aoeeoey?iiai eiiieaeno, ye? iio?aaothoue ei?aeoe??. Aaa?oi?noue aeey oeeo ae?iie, a?eueo?noue c yeeo a?aeianai? aei o?eaiaeieo noa’?eo?a, noaaaea aiioe?eiei no?anii, ui i?e-caiaeeei aei ii?ooaiiy ineoiaaaaoaoeaiiai ?aaaoaaiiy ia ineo?/i? oa o?ce/i? iaaaioaaeaiiy, oi?ioaaiith ineoiaaaaoaoeaiiai neiae?iio ? aoei oiiii aeey ?icaeoeo oneeaaeiaiue aaa?oiino? oa iieiaiaiai aeoo. Iaa?oue iacia/ia IAI ca aenieiai ??aiy iniaenoi? o?eaiaeiino? o?ainoi?ioaaeanue o oeeo iaoe??ioie a iniaeeai aeooaeueio iiaaae?ieo oa aeeeeeaea iaaaeaeaaoio a?inioe?aeueio ?aaeoe?th. C ianoaiiyi aaa?oiino? a ? o?eiano?? o iaoe??ioie c AON aoei aeyaeaii o?eaiaeii-iaa?ioe/i? ?iceaaee, a oaeiae aenieee ??aaiue aeanii? o?eaiae o ii-??aiyii? c iaoe??ioeaie, aaa?oi?noue o yeeo ?icaeaaeany o?c?ieia?/ii (? a?oia – 57,6(1,5, ?? a?oia – 62,4(1,4, eiio?ieue – 32,6(2,1 aaee). A?aeiinii aenieee ??-aaiue aeanii? o?eaiae a ? o?eiano?? o ae?iie eiio?ieueii? a?oie iiynithaaany oei, ui iaeaea o o?aoeie oeeo iaoe??ioie c ianoaiiyi aaa?oiino? a?aei?/aeiny ii?ooaiiy ineoiaiioe?eiiai noaio: iano?ee?noue iano?ith, ieaenea?noue, a?ae/oo-oy o?eaiae, aeaoo ? i?eai?/aiino?. Oe? ineoiaaii? ii?ooaiiy iineee aaeaioea-iee oa?aeoa? ?, ye i?aaeei, i?eieiyeenue iai?ee?ioe? ? o?eiano?o aaa?oiino? aac e?eoaaiiy. A ?? o?eiano?? niinoa??aaany ia??iae a?aeiiniiai niieith, aea ??-aaiue neooaoeaii? o?eaiae caeeoaany a?eueo aenieei a ?? a?oi? (? a?oia – 38,9(0,9, ?? a?oia – 48,4(1,7, eiio?ieue – 16,3(0,3 aaee). Ia?aae iieiaaie a ? a?oi? oeae iieaciee c?inoaa aei 49,1(1,3 aaee, a ?? a?oi? a?i aoa cia/ii aeuei – 59,6(1,7 aaee. Oae? yaeua i?eaiaeeee aei iineeaiiy iai?oaeaiino? a aaeai-oeaieo nenoaiao oa caa?ice ia?a?eaaiiy aaa?oiino?, iiyae i?ci?o aanoic?a, ia-?aae/aniiai ?ic?eao ie?aeieo iaieiiie, aeeneii?aeeiaoe?? iieiaiai? ae?yeueiino? oa ?ioeo oneeaaeiaiue. ?acoeueoaoe aeanieo aeine?aeaeaiue oa aiae?c e?oa?aoo?ieo aeaieo (Ia??nii O.C. c? ni?aaao., 1984; ?iiaiaiei O.A., 1998; O?ieia A.A., 1987) na?ae/aoue i?i oa, ui aaaaoaoeai? ii?ooaiiy, ye? noi?iaiaeaeothoue aiioe?e-iee noai, e?euee?nii caeaaeaoue a?ae neee iioeaaoe?? oa a??ia?aeiino? ?? caaeia?eue-iaiiy. Ii i??? c?inoaiiy iaaiaaiaiino? a caaeia?eueiaii? iioeaaoe?? iaoa?ei-noaa (iineeaiiy iciae caa?ice ia?a?eaaiiy aaa?oiino?) a?aecia/aeenue i?aeae-uaiiy a?oa??aeueiiai oeneo (AO), /anoioe na?oeaaeo nei?i/aiue (*NN), iine-eaiiy (-?eoio AAA. IAI oaeiae caeaaeaea a?ae no?ieo aanoaoe??: aiia aoea a?eueo aecia/aia a ? oa iai?ee?ioe? ??? o?eiano??a aaa?oiino?, iniaeeai o ae?iie ?? a?o-ie. *anoi iaoe??ioee ia iiaee a?ae??cieoe neiioiie, ui noi?iaiaeaeothoue o?c?-ieia?/iee ia?aa?a aaa?oiino?, a?ae a?aeiieo ?i ca ieioeei aeina?aeii iciae ca-a?ice ia?a?eaaiiy aaa?oiino?, a ca’yceo c /ei c?inoaa no?ao iiaoi?aiiy ia-ni?eyoeeaiai ?acoeueoaoo. I?e oeueiio c?inoaee iieacieee *NN, AO ca a?aenoo-iino? iciae caa?ice ia?a?eaaiiy aaa?oiino?. Noaaaei i/aaeaeiei, ui a ?ac? CIA i?e AON a eiiieaen ?aaa?e?oaoe?eii? oa?ai?? ia noaae?? ieaioaaiiy aaa?o-iino?, a oaeiae c ?? ianoaiiyi, iaiao?aeii aeeth/aoe ? ineoioa?aiaaoe/io ei-?aeoe?th. Ianoaaeaiiy ?ioiiiai noaoono iaoe??ioie i?iaiaeeeeny iica aaa?oi?noth oa i?ney ?? ianoaiiy i?ioyaii anueiai no?ieo aanoaoe??. Ia ia?oiio aoai? ?io-iieia?/iiai ianoaaeaiiy iaoe??ioie c? CIA aoei i?iaaaeaii eiiieaenio ae?aa-iinoeeo iayaiino? AON iaoiaeii aecia/aiiy iayaiino? AA oa niaoeeo?/ieo AOEA, a oiio /ene? ? aioeea?ae?ie?i?iiaeo aioeo?e (AEEA). Aoei aeyaeaii iiceoeaiee oano ia AA o 100 % aeiaaee?a, AOEA – 86,4%, AEEA – 76,1% niinoa?aaeaiue. Iayai?noue aooi?ioiiiai i?ioeano aeeeooaaea iaiao?aei?noue aei-ne?aeaeaiiy caaaeueiiai ?ioiiiai noaoono, a naia: ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo, oaeoi??a ianiaoeeo?/iiai caoenoo, ??aiy nainea?e?caoe?? aei i?e?ia-ieo oa oaoaeueieo aioeaai?a, eiioeaio?aoe?? oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E). O ae?iie c AON aoee iciaee ae?acieo ii?ooaiue ?ioiieia?/iiai ai-iainoaco, ye? i?iyaeyeeny /a?ac oi?ioaaiiy ?ioiiaeao?oeeoiiai noaio (?AeN) oa ?ioiiiaoieia?/ieo i?ioean?a, eio?? ni?eyee i?aeo?eioe? nainea?e?caoe?? ?AeN ca aeaii? iaoieia??, oa?aeoa?ecoaaeenue ci?oaiei ii?ooaiiyi iaoai?ci?a ia?-aeiii? ?ioiii? a?aeiia?ae?, i?i ui na?ae/eei i?aeaeuaiiy a?aenioeiaiai neeaaeo O-ee?oeiiiai ?ioi?oaoo (ca aeiyoeii O-noi?ani??a), CD16, eiioeaio?aoe?? IgM, IgE oa cieaeaiiy ??aiy A-ee?oei, IgG, eiiieaiaioo, a oaeiae i?eaiiaeaiiy iae?ioaaioeeoa?ii? aeoeaiino? (?en.6). Aiane?aeie oeueiai a?aeaoaaeanue iineea-ia eieii?caoe?y i?aai?cio iaoiaaiiith oei?ith, a oaeiae a??oniith ia?nenoo-th/ith ?ioaeoe??th, i?i ui na?ae/aoue aeai? ee?i?/ii? oa?aeoa?enoeee ianoaaeaieo iaoe??ioie. Iaea?eueo i?iaiinoe/iei aeyaeeinue ni?aa?aeiioaiiy CD4/CD8, yea ao-ei i?aeaeuaia ca ?aooiie cieaeaiiy CD8 (?en.7). I?aeaeuaiiy eiioeaio?aoe?? CD16 ciaoiaeeeinue a i?yii i?iii?oe?ei?e ca-eaaeiino? a?ae e?eueeino? ?ai?iaeoeoeaieo ao?ao, ui aeaco? ia aaaeeeao ?ieue oeueiai ia?ea?a i?e ianoaaeaii? iaoe??ioie c AON oa aeeaeio ?ioiieo c?ooaiue. ?ioiieia?/i? ?aaeoe??, ye? aeeeeeathoue i?aeaeuaiiy Oe?E oa nainea?e?caoe?th aei oeaieiieo aioeaai?a, aa?ooue o/anoue a ?icaeoeo CIA, ?ioeo aanoaoe?eieo one-eaaeiaiue (OII, C?I, aanoic) (?en.8). Ae?aci?noue ?ioiieo oa ?ioiiiaoieia?/ieo ?aaeoe?e a cia/i?e i??? ca-eaaeaea a?ae e?eueeino? ia?eiaoaeueieo ao?ao, noi?ia?aeieo o?ii?/ieo aaeoa??a-eueieo, a??onieo caoai?thaaiue oa nooiaiy o?ii?/iiai no?ano. Ci?ie ?ioiiei-a?/iiai aiiainoaco o ae?iie c AON iiaeia ?icoe?ieoe ye iineeaiiee oei ?ioiii? a?aeiia?ae? aac aeinoaoiuei? ?ioiinoi?an??, oa?aeoa?ii? aeey o?c?ieia?/ii? aaa?oiino?. I?iaaaeai? iaie aaiinoac?ieia?/i? aeine?aeaeaiiy o iaaaa?oieo oa aaa?o-ieo ae?iie c AON iieacaee, ui o inoaii?o ?a?no?oaaeeny nooo?a? ci?ie a nen-oai? aaiinoaco. C ? o?eiano?o aaa?oiino? o iaoe??ioie aoei aeyaeaii a?ia?eia-aoeyoe?th o?iiaioeeo?a i?e ?o ii?iaeuei?e e?eueeino?, o iiaeaeueoiio – a?ia?eia-aoeyoe?th a ieaci?. Eiioeaio?aoe?y o?a?eiiaaio oa noia?ia ioe?iea oaeoi??a cai?oaiiy (A*O*, eaie?iiaee /an, i?io?iia?iiaee ?iaeaen, oiea?aioi?noue ieacie aei aaia?eio) caeeoaeeny aeineoue aenieeie. A ia?aaaaei?e e?eueeino? aeiaaee?a niinoa??aaeany iii??ia oa eiiiainiaaia a?ia?eiaaoeyoe?y, eio?a ia noi?iaiaeaeoaaeany aeoeaaoe??th o?a?eiie?co (?en. 9). Ia iniia? i?iaaaeaiiai eiiieaeno aeine?aeaeaiue iaie ?ic?iaeaii eii-oeaioe?th ?icaeoeo AON ? aanoaoe?eieo oneeaaeiaiue i?e iueiio (?en.10). O?ii?/-ia aiaeiaaiia ?ioieneeaoe?y, iaoiiaeaia a??onieie aai aaeoa??aeueieie ?ioae-oe?yie, a?aaea? ?ioiieiiiaoaioi? ee?oeie. Aeieea? niioai?aia a?aeiia?aeue O-ee?oeiiiai ?ioi?oaoo o aeaeyae? aa?an?? aei aeanieo ee?oei ? oeaiei, yea iineoue aooi?ioiiee oa?aeoa?, ui ee?i?/ii ia i?iyaey?oueny. C ianoaiiyi aaa?oiino?, eiee ii/eia?oueny ?ioiinoi?an?y O-ee?oeiiiai ?ioi?oaoo, aooi?ioiiee i?i-oeann caaino?th?oueny o aeaeyae? eieaeueiiai (ia iaae? i?ae iaoa?einueeei i?aai?c-iii ? ieiaeii a iaeano? ieaoeaioe) oa nenoaiiiai oa?aeoa?o. ?ioiiee eiio-e?eo i?iyaey?oueny ?icaeoeii nenoaiii? a?ia?eiaaoeyoe?? aiane?aeie i?aeaeuaii? i?iaeoeoe?? aooiaioeo?e aei oinoie?i?ae?a iaia?ai ee?oei aiaeioae?th noaeei, o?iiaioeeo?a, o?ioiaeanoo. Oeei aecia/a?oueny ee?i?/ia ea?oeia aanoaoe?eieo oneeaaeiaiue: caa?ica ia?a?eaaiiy aaa?oiino?, cae/iee aeeeaeaiue, C?I, niii-oaiia a?aeoa?oaaiiy ii?iaeueii ?icoaoiaaii? ieaoeaioe, a?iien?y ieiaea. sse iane?aeie ?ai?iaeoeoeaieo ao?ao iaynii? ao?ieia?? o iaoe??ioie aeieea? IAI, ui ni?ey? i?aeaeuaiith eiioeaio?aoe?? ai?iii?a ? iaae?aoi??a no?ano c ianooi-iei ii?ooaiiyi ?ai?iaeoeoeaii? ooieoe?? oa i?eai?/aiiyi ?ioiieiiiaoaio-ieo ee?oei. Oae aeieea? oeaia eiei: ia?aae?ciaaia iaoa?einoai, ui ? iane?ae-eii caianeiaaiiai aooi?ioiiiai neiae?iio, aeeeeea? o?ii?/iee no?an, eio-?ee iiaeeaeth? aooi?ioiia caoai?thaaiiy ? i?eaiaeeoue aei ii?ooaiiy ?ai?i-aeoeoeaii? ooieoe??. Iaie nenoaiaoeciaaii oa oaeineiiaeaii ee?i?ei-eaai?aoi?i? e?eoa??? ae?aaiinoeee AON, ye? canoiniaoaaeenue a aeooa?nuee?e i?aeoeoe? (?en.11). Ia-noaaeaiiy ia AON iaiao?aeii i?iaiaeeoe i?e oaeeo iaoieia?/ieo noaiao: iaya-i?noue a aiaiiac? aeaio oa a?eueoa naii/eiieo aai?o?a aai ia?icaeiooi? aaa?o-iino? a ?-?? o?eiano?ao; iiaoi?aiiy aioaiaoaeueieo ao?ao i?e ianooiieo aa-a?oiinoyo a ??-??? o?eiano?ao, a oaeiae caaeaaeue aeiiioaieo iiaiia?iaeaeaieo ae?oae a ia?o? 2-3 aeiae i?ney iieia?a iaynii? ao?ieia??; C?I; iaaeiiooaaiiy aaa?oiino? o ae?iie c ??cieie i?iyaaie aooi?ioiiiai neiae?iio ?ai?iaeoeoea-ieo ii?ooaiue (iaaeinoaoi?noue y?/iee?a, aiaeiiao??ic, iaoieia?y ueoiaeaeii? caeice e iaaeie?eiaee?a); oyaee? oi?ie aanoico, o?ii?/iee a’yei ia?aa?aath-/ee i??eiiao?eo; aeeoocia caoai?thaaiiy c’?aeioaaeueii? oeaieie; o?ii?/iee aeoeaiee aaiaoeo, ianiaoeeo?/iee ae?aceiaee eie?o, oai?iaa E?iia; aa?ia-oe/ia ?ioaeoe?y (OeIA oa aa?ian); a?o?aea?/iee neiae?ii aai ?aaiaoi?aeiee a?o?eo; iie?aaeaioia aea?a?y ia e?ea?nuee? i?aia?aoe; aaiie?oe/ia aiai?y, o?iiaioeeoiiai?y. A ?iaio? aeiaaaeaii, ui iiceoeaiee aaiinoac?ieia?/iee oano ia AA (eaie?iiaee /an) ? aeoaea aaaeeeaei ae?aaiinoe/iei e?eoa???i iaya-iino? AON ia??ai? c na?ieia?/ieie oanoaie ia AOEA. Ioaea, iayai?noue ia?e-iaoaeueieo ao?ao a ii?aeiaii? c iiceoeaiith i?iaith ia AA ? i?aenoaaith aeey anoaiiaeaiiy ae?aaiico AON. I?ney anoaiiaeaiiy ae?aaiico iaaeae? iaoe??iooe? i?iaiaeeeinue e?eoaaiiy ca cai?iiiiiaaiith i?ia?aiith ?aaa?e?oaoe??, iniiaieie i?eioeeiaie yei? ?: na-iaoe?y ina?aaee?a ?ioaeoe?? i?e ?o iayaiino? (ieaaeaeeie oa ?i.); e?eoaaiiy o?i-i?/ieo a??onieo caoai?thaaiue (aa?ian, OeIA, o?iaai?oaeueia ?ioaeoe?y); ei?ae-oe?y aeenooieoe?? y?/iee?a, ueoiaeaeii? caeice i?e aeyaeaii? a?aeoeeaiue a oiae? ai?iiiaeueiiai ianoaaeaiiy (o?oioa?ai?y, eaca?i?aoeaenioa?ai?y, ci?iia ci-iaeueia aeaeiii?an?y, canoinoaaiiy ai?iiiaeueii? ei?aeoe??); aeaaaeaiiy AOEA c i?aai?cio ca aeiiiiiaith aoa?aioieo iaoiae?a e?eoaaiiy; ?ioiinoi?an?y aooi?ioiiiai noaio aeaenaiaoaciiii; ?ai,- ?ioiiei?aeoe?y; ineoioa?aiaaoe/ia ?aaa?e?oaoe?y. Ia?oee aoai e?eoaaiiy i?iaiaeeee ca oiiae eiio?ieth ?ioiieia?/ieo, aaiinoac?ieia?/ieo, a?io?i?/ieo iieaciee?a. I?e iaaaoeaieo na?ieia?/ieo oanoao oa oano? ia AA iaoe??iooe? aeaaaee aeica?e ia ieaioaaiiy aaa?oiino?. C ii-iaioo ae?aaiicoaaiiy aaa?oiino? iaoe??ioee iiiaaeaee i?ae ?aoaeueiee aeeniai- na?iee eiio?ieue, ine?eueee aiie neeaaeaee a?oio ?eceeo: ?nioaaea caa?ica ia-aeiiooaaiiy aaa?oiino?, ?icaeiaiiy aanoico, OII, o?iiaiaiaie?/ieo on-eeaaeiaiue, ii?ooaiue ia?aa?ao iieiaiai? ae?yeueiino?. Iaoe??ioee aini?oae?coaa-eenue a niaoe?ae?ciaai? a?aeae?eaiiy iaoieia?? aaa?oiino? aeey i?io?eaeoeee ? e?eo-aaiiy iiaeeeaeo oneeaaeiaiue, anaa?/iiai ianoaaeaiiy i?aai?cio oa aiae?co io-?eiaieo ?acoeueoao?a. Ae?oaee aoai e?eoaaiiy cae?enithaaee i?ioyaii anueiai no?ieo aanoaoe??, caaaeath/e ia iniaeeaino? ia?aa?ao AON i?ae /an aaa?oiino?. E?eoaaiiy i?iai-aeeee a e?eoe/i? no?iee aaa?oiino?, eiee ii/eiaeeny aeacaaeaioaoe?ei? i?ioeane oa ?icaeaaeanue caa?ica ia?a?eaaiiy aaa?oiino?, OII, C?I, oyaee? oi?ie aan-oico, o?iiaiaiaie?/i? oneeaaeiaiiy aoaeue-yei? eieae?caoe??, ui ? oa?aeoa?iei aeey AON. Oe? no?iee: 6-7 oeaei?a, 10-12 oeaei?a, 24-26 oeaei?a, 30-32 oeaei? aan-oaoe??. E?eoaaiiy i?iaiaeeee i?ae eiio?ieai aaiinoac?ieia?/ieo, ?ioiieia?/-ieo, ai?iiiaeueieo aeine?aeaeaiue iieaciee?a i?aai?cio aaa?oii?, a oaeiae OCAe oa EOA ieiaea. ?aiei?aaoth/a oa?ai?y aoea aoaeoeaiith i?e ii?aeiaii? aioeaa?aaaio-ieo oa ?aiei?aaoth/eo i?aia?ao?a: ?aiiie?aetheei, 400,0 ie a/a ? 5 a ii?ae-iaii? c eo?aio?eii, 2 ie ia 450,0 ie o?c?ieia?/iiai ?ic/eio a/a ? 5 (oe? i?a-ia?aoe aaiaeyoue ii /a?c? c ?ioa?aaeii 1-2 aei?); na?i?ii, 4 ia ia 200 ie o?c?i-eia?/iiai ?ic/eio a/a ? 3 /a?aothoue c ?aiaethiaiii, 400,0 ie a/a ? 3, 1 ?ac ia 3 aei?; o?aioae, 1 ie ia 500,0 ie o?c?ieia?/iiai ?ic/eio a/a ? 3 /a?aothoue c aaiiaeacii, 400,0 ie a/a ? 3, 1 ?ac ia 3 aei?. Eo?n e?eoaaiiy 10-12 ?iooc?e. Ei?oeeinoa?i?aeia oa?ai?y a?oiooaaeanue ia i?eeii? aeaenaiaoaciio a oaaeaoeao ii 0,5 ia 1 ?ac ia i?/. Aeey oeo, ooi i?eeiaa aeaenaiaoacii i?ae /an eo?no ?aaa?e?oaoe?? ca 3-4 i?nyoe? aei aaa?oiino?, aeico ciaiooaaee aei 0,4-0,5 oaae. ia i?/ i?ioyaii 3-4 oeaei?a. ?ioiiaeiaoe?i ethaeeie ieaoeaioa?iee i?ecia/aee a e?eoe/i? no?iee aa-noaoe?? a aeic? 4,5ie ? 3 c ?ioa?aaeii a 2 aei?. Aeueoa?iaoeaiei aoa ?ioiiaeiao-e?i aeey a/a aaaaeaiiy ii 50 ie ia 150 ie o?c?ieia?/iiai ?ic/eio, 3-5 ?i’?eoe?e. I?ecia/aee ieaciaoa?ac oa ieaciini?aoe?th, ae?y yeeo ni?eyea cieaeai-ith a’yceino? e?ia?, iie?ioaiith i?e?ioee?eoeyoe??, oeaieiiiai iaoaaie?cio, ooieoe?iioaaiiy ?ioiii? nenoaie. I?iaiaeeee 3-4 naaine c ia?a?aaie a 2-3 aei?. Ca naain aeaeaeyee 900-1100 ie e?ia?, cai?ithth/e e?enoaei?aeieie ?ic/e-iaie. I?e ieaciini?aoe?? a?aeie?aieaio iaoiaeii a?aa?oaoe?eii? o??o?a?? ieac-io ia?aioneaee /a?ac aieieienoee aeae?aaiaeecoth/ee ieaciini?aaio, i?ney /iai i/euaio ieacio iiaa?oaee o aaio iaoe??ioee. Aioeeiaaoeyioia oa?ai?y cae?enithaaeanue ca ?aooiie i?eeiio o?aene-ia?eio, 0,3-0,6ia 1 ?ac ia aeaiue, i/o, 1-5 oeaei?a i?ae eiio?ieai aaiinoac?ia?a-ie (oaae.3). E?eoaaiiy OII ii/eiaee c ? o?eiano?o aaa?oiino?. Aiii aeeth/aei i?eeii i?aia?ao?a iaoaaie?e?a: anaioe?aea, 5,0ie+5,0ie aooie?ia? a/a, iia?eue-ii, ? 5-10 aai e?iinoaa?e, 5,0 ie+5,0 ie aooie?ia? a/a, ? 5-10 (aeae? ua 10-15 aei?a i?iaeiaaeoaaee i?eeii oeeo aea i?aia?ao?a ia?i?aeueii); anei?a?iiai? ee-neioe, 4,0 ie (5 %), a/i, ? 10-15 oa AOO, 1 ie a/i /e eiea?aieneeace, 100,0 ie a/a ?10-15; cae?ca oa oie??ai? eeneioe: oaoie ii 1 eainoe? 3 ?ace ia aeaiue, 20-30 aei?a. I?ioyaii anueiai no?ieo aanoaoe?? (iniaeeai a ?, ??? o?eiano?ao oa ia?aae iieiaaie) i?iaiaeeee naaine ineoioa?ai?? c canoinoaaiiyi oa?ai?? aeey ?aeae-naoe?? oa aeaeo?inio. Iaie ?ic?iaeaii oaeoeeo aaaeaiiy aaa?oiino? oa iieia?a o iaoe??ioie c AON. I?e iayaiino? aioeo?e aei an?o iniiaieo iaia?aiieo oinoie?i?ae?a aai iiceoeaii? ?aaeoe?? ia AA e?eoaaiiy iaiao?aeii i?iaiaeeoe, ye a?aecia/aii ?ai?oa, i?ae eiio?ieai OCAe, EOA ieiaea, aaiinoac?ieia?/ieo oa ?ioiieia?/ieo iieaciee?a. Iieiae iiaeia i?iaiaeeoe eiina?aaoeaii i?e a?aenooi?no? aeooa?-nueeeo oneeaaeiaiue (aocueeee oac, aaeeeee ie?ae oa ?i.). Eiee a aiaiiac? aoee o?iiaioe/i? aai aaneoey?i? oneeaaeiaiiy ??cii? eieae?caoe??, e?eoaaiiy ne?ae i?iaiaeeoe a iiaiiio ianyc? c iaia’yceiaei aeeiiaiiyi ieaciaoa?aco oa ieaciini?aoe??. I?e iayaiino? C?I ? i?ciueiai aanoico o?aaa noaaeoe ieoaiiy i?i eana??a ?icoei a ca’yceo c iaaoaeoeai?noth e?eoaaiiy AON; i?e ii?aeiai-i? i?ciueiai aanoico, C?I, iaei- aai aaaaoiaiaeaey i?ney iaaeiaai? i?aeaioiaee c iaia’yceiaei i?iaaaeaiiyi ieaciaoa?aco oa ieaciini?aoe?? iaiao?aeii ?iaeoe eana??a ?icoei c iaia’yceiaith i?io?eaeoeeith o?iiaiaiaie?/ieo oneeaaeiaiue a i?neyiia?aoe?eiiio ia??iae? ia i?ioyc? 2-3 oeaei?a i?ae eiio?ieai aaiinoa-c?ia?ai ? oeo?o AOEA. Aiae?c io?eiaieo ?acoeueoao?a aeicaieea c?iaeoe aeniiaie, ui i?iaaaeaiee eiiieaen e?eoaaeueii-i?io?eaeoe/ieo caoiae?a ae-yaeany aoaeoeaiei. Iieacieee aaiinoac?ieia?/iiai, ?ioiiiai oa ai?ii-iaeueiiai noaoon?a aaa?oieo ? a?oie iaaeeaeaeeny aei iieaciee?a, ui niinoa??-aaeeny a a?oi? ae?iie c o?c?ieia?/iei ia?aa?aii aaa?oiino?. Aiaeia?/i? iieac-ieee iaoe??ioie ?? a?oie aoee cia/ii a??o? (oaae. 4,5). A ? a?oi? iaoe??ioie /anoioa oneeaaeiaiue ia?aa?ao oaia??oiuei? aaa?oiino? aoea a??ia?aeii ieae/ith a ii??aiyii? c ?? a?oiith (?en.12). A a?oi?, aea i?iaiaeeee eiiieaen cacia/aieo e?eoaaeueii-i?io?eaeoe/-ieo caoiae?a aei oa i?ney ianoaiiy aaa?oiino?, a?ae 80 aaa?oieo iaoa??a ia?iaee-einue 78 aeeoo?caeaoieo ae?oae, o 2 aaa?oieo noaany i?ci?e naii/eiiee aai?o ca oeiii caaia?ei? aaa?oiino? a oa?i?i? 18-24 oeaei? aanoaoe??, ca?a?no?iaaii aioaiaoaeueio caaeaaeue ieiaea o 1 c aea?ei? i?e ia?aae/anieo iieiaao. A a?oi? aaa?oieo, ye? io?eioaaee caaaeueiii?eeiyoo oa?ai?th caa?ice ia?a?eaaiiy aa-a?oiino?, ?acoeueoao aoa ?ioee: a ? o?eiano?? ia?a?aaeiny 14 aaa?oiinoae c 60 (23,3 %), i?ci?e naii/eiiee aai?o noaany o 10 (16,7 %) iaoe??ioie, o 10 (16,7 %) a?aeaoeenue ia?aae/ani? iieiae, 5 iiaiia?iaeaeaieo iiia?ee /a?ac 2 aeiae i?ney ia?iaeaeaiiy a?ae neiae?iio aeeoaeueieo ?iceaae?a (NAe?) oa iaaeinoao-iino? e?iaiia?ao a iiceo, 16 ae?oae ia?aaaee aeey iiaeaeueoiai e?eoaaiiy a iaeanio aeeoy/o e?ea?ith (?en.13). I?e aeine?aeaeaii? noaio caei?ia’y iiaiia-?iaeaeaieo a?ae iaoa??a c AON anoaiiaeaii, ui o ae?oae, iaoa?? yeeo e?eoaaeenue ca ?ic?iaeaiith iaoiaeeeith, ia?aa?a ?aiiueiai iaiiaoaeueiiai ia??iaeo oa?ae-oa?ecoaaany eiiiainiaaiei ii?ooaiiyi a?ieia?/ieo i?ioean?a, /anoioa ca-oai?thaaiue o ieo aoea cia/ii iaioith, i?ae o ae?oae, iaoa?? yeeo iaea?aeaee ca-aaeueiii?eeiyoo oa?ai?th (?en. 14). Io?eiaia ee?i?/ia ?ioi?iaoe?y i?i aeieeiaiiy, ?icaeoie oa ee?i?/i? i?iyae AON a aeooa?nuee?e i?aeoeoe?, a oaeiae ?ic?iaeaiee ? ai?iaaaeaeaiee eiiieaen i?io?eaeoe/ieo, ?aaa?e?oaoe?eieo oa e?eoaaeueieo caoiae?a aea? iiae-eea?noue cieceoe ieoiio aaao oneeaaeiaiue aaa?oiino?, ia?eiaoaeueii? caoai?th-aaiino? oa nia?oiino? AENIIAEE AON cono??/a?oueny o 37,3% ae?iie c ia?eiaoaeueieie ao?aoaie iayniiai aaiaco, noi?iaiaeaeo?oueny iaoieia?/iith aeoea?caoe??th aioo??oiueinoaeeiiiai cn?aeaiiy e?ia?, ci?iith O-, A-ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo, ineoi-iae?iaaaaoaoeaieie ii?ooaiiyie ca oeiii o?ii?/iiai no?ano aiane?aeie ia-?aae?ciaaiiai iaoa?einoaa. Iniiaiei ni?eyoeeaei oaeoi?ii aeey ?icaeoeo AON ? o?ii?/ia ?ioae-oe?y (oiiceeiaaiia – 60,0 %, OeIA, aa?iaoe/ia – 34,3 %, o?iaai?oaeueia – 20,1 %), yea i?ecaiaeeoue aei ?icaeoeo aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? c ianooiiei ii?ooaiiyi ?ai?iaeoeoeaii? ooieoe??. Iae/ano?oeie oneeaaeiaiiyie aaa?oiino? i?e AON ? caa?ica ?? ia?a?e-aaiiy (48,9 %), OII (88,9 %), C?I (33,3 %), aioo??oiueioo?iaia caaeaaeue ieiaea (111,1(), o?iiaiaiaie?/i? oneeaaeiaiiy o iaoa?? (7,5 %). O iaoe??ioie c AON i?ae /an aaa?oiino? oa iica iath aeyaeaii ca?eueoaiiy ai?noo CD3, CD16, ca?eueoaiiy a?aeiioaiiy CD4/CD8 ca ?aooiie cieaeaiiy CD8. Aeyaeaii ca?eueoaiiy Oe?E oa cieaeaiiy eiiieaiaioo, iaoieia?/io nainea?-e?caoe?th aei oaoaeueieo aioeaai?a (IEN i?aeaeuo?oueny a 2 oa a?eueoa ?ac?a). Ia?eiaoaeuei? ao?aoe o iaoe??ioie c AON aeeeeeathoue IAI, eio?a aeya-ey?oueny /a?ac ?icaeoie o?eaiaeii-iaa?ioe/ieo ?iceaae?a, ui ni?ey? c?inoai-ith eiioeaio?aoe?? a e?ia? ai?iii?a oa iaae?aoi??a no?ano, ?a?no?othoueny iciaee aeacaaeaioaoe?? ia AAA aae aei c?eao aaa?oiino?. Ca aeaieie aaiinoac?ieia?/iiai iii?oi?eiao c ? o?eiano?o aaa?oiino? a?aecia/athoueny ci?ie iieaciee?a e?ia? o aeaeyae? a?ia?aa?aaaoe?? o?iiaioeeo?a, a?ia?eiaaoeyoe?? a ieaci? oa iiyae iaoieia?/ieo ia?ea??a neiae?iio aeenai?ii-aaiiai aioo??oiueinoaeeiiiai cai?oaiiy e?ia? a ?? oa ??? o?eiano?ao. Ii?oieia?/i? oa a?noio?i?/i? aeine?aeaeaiiy ieaoeaioe i?aeoaa?aeeee iea-oeaioa?io iaaeinoaoi?noue ??ciiai nooiaiy ae?aciino?, yea ?icaeaaeanue c ? o?e-iano?o aaa?oiino? ? oa?aeoa?ecoaaeanue cieaeaiiyi ??aiy eiioeaio?aoe?? OAA, AIAO, A3, IE, i?aeaeuaiiyi ??aiy IAIA, a?iien??th oa C?I. Eiiieaenia oa?ai?y, yea ni?yiiaaia ia iie?ioaiiy ?ioiiiai, ai?ii-iaeueiiai, aaiinoac?ieia?/iiai oa in?oiaiioe?eiiai noaoono ? ooieoe?? oaoiiea-oeaioa?iiai eiiieaeno o iaoe??ioie c AON, ni?ey? cieaeaiith oneeaaeiaiue aa-a?oiino? oa ia?iaeaeaiith aeeoo?caeaoieo ae?oae a 97,5 % aeiaaee?a. O ae?oae a?ae iaoa??a c AON, ui i?eeiaee eiiieaenio oa?ai?th, a iai-iaoaeueiiio ia??iae? niinoa??aaeiny cieaeaiiy /anoioe ?ioaeoe?eii-caiaeueieo caoai?thaaiue, ano?en??, ii?ooaiiy iiceiaiai e?iaiia?ao, neiae?iio i?aeaeua-ii? ia?aiai-?aoeaeoi?ii? caoaeaeaiino? oa iie?ioaiiy iieaciee?a ?ioiiiai noaoono a ii??aiyiiy c iiaiia?iaeaeaieie, iaoa?? yeeo io?eioaaee o?aaeeoe?e-ia e?eoaaiiy. I?AEOE*I? ?AEIIAIAeAOe?? Iaoe??ioeai, ye? iathoue iaoyaeaiee aeooa?nueeee aiaiiac (CIA, neiae?ii C?I, oyaee? oi?ie i?ciueiai aanoico, aioaiaoaeueia caaeaaeue ieiaea oa ?aiiy iaiiaoaeueia nia?oue iiaiia?iaeaeaiiai iaynii? ao?ieia??, o?iiaiaiaie?/i? ai?ciaee ??ciiiai?oii? eieae?caoe??, i?enooi?noue OeIA, o?ii?/iiai aeaeiiiaini-aaiiai oiicee?oo, aea?a?/ieo oneeaaeiaiue) iieacaia ne?ei?iaiaa ianoaaeaiiy ia iayai?noue AON (aecia/aiiy AA, AEEA IgG+I, AOEA IgG+I) aei ianoai-iy aaa?oiino? /e c ia?oeo ?? oeaei?a. An?i iaoe??ioeai c AON iaiao?aeii i?iaiaeeoe ne?ei?iaiaa ianoaaeaiiy ineoiaiioe?eiiai noaio (oanoe Ni?eaa?aa?a oa Ethoa?a) oa aaaaoaoeaii? ia?-aiai? nenoaie (oano Aaeia, ?iaeaen Ea?aei) ia aoai? ieaioaaiiy oa c ianoaiiyi aaa?oiino? aeey nai?/aniiai i?iaaaeaiiy ineoioa?aiaaoe/ii? ?aaa?e?oaoe??. I?ia?aio e?eoaaeueii-?aaa?e?oaoe?eieo caoiae?a, ui aeeth/a? ?ai,- ?ioii-ei?aeoe?th, canoinoaaiiy aioeaa?aaaioieo oa aioeeiaaoeyioieo i?aia?ao?a, aoa?aioi? iaoiaee (ieaciaoa?ac oa ieaciini?aoe?th), iaiao?aeii cai?iaaaeaeo-aaoe ca 4-6 i?nyoe?a aei aaa?oiino? iaoe??ioie. I?e ii?iae?caoe?? iieaciee?a ?ioii- oa aaiinoac?ia?aie iiaeia ?aeiiaiaeoaaoe ieaioaaiiy aaa?oiino?. C ianoaiiyi aaa?oiino? ?aeiiaiaeo?oueny i?ecia/aoe ia iaioa 4-o eo?n?a e?eoaaiiy a e?eoe/i? no?iee aaa?oiino? (6-7, 10-12, 24-26 oa 30-32 oeae.) ca oiiae eiio?iethaaiiy aaiinoac?i- oa ?ioiia?aie, ia?ea??a AON, EOA oa OCAe. I?e iiaeeeaino? oaeiae i?iaiaeeoe ai?iiiaeueiee iii?oi?eia: OII (A2, A3, I, IE, OAA), E, oanoinoa?ii. Aeey a?eueo aoaeoeaii? ei?aeoe?? aaiinoac?ieia?/ieo iieaciee?a ?aei-iaiaeo?oueny ii?aeiaiiy aioeaa?aaaio?a c o?aeneia?eiii oa aoa?aioieie ia-oiaeaie. I?e aeai?? oaeoeee aaaeaiiy aaa?oiino? oa iaoiae?a ?ic?iaeaeaiiy iaoe??i-oie c AON o?aaa a?aoiaoaaoe aeae neiae?iio, ii?aeiaiiy eiai c o?iiaioe/-ieie ai?ciaeaie a aiaiiac?, noaiii ieiaea oa iayai?noth OII. Eiina?aaoeaia aaaeaiiy iieia?a aeicaieaii i?e iaiaoyaeaiiio ia?aa?ao AON, eiiiainiaa-iiio noai? ieiaea, a?aenooiino? neiae?iio C?I oa aanoico. I?e iayaiino? OeIA, o?iiaioe/ieo ai?ciae?a a aiaiiac?, aanoico, noa- oa aeaeiiiainiaaieo noai?a ieiaea a ii?aeiaii? (aai aac) ?c cao?eieith eiai ?icaeoeo, a oaeiae iaaoaeoea-iiio e?eoaaii? aaiinoac?ieia?/ieo ii?ooaiue ?aeiiaiaeo?oueny aeeiioaaoe iia?aoeaia ?ic?iaeaeaiiy oeyoii iia?aoe?? eana?nueeiai ?icoeio. O iaoe??ioie c AON i?ney iieia?a ?aeiiaiaeo?oueny i?iaeiaaeeoe ei?oe-einoa?i?aeio, aioeaa?aaaioio oa?ai?th c iaia’yceiaei i?iaaaeaiiyi 1-2 naain?a ieaciaoa?aco a i?neyiieiaiaiio ia??iae? i?ae eiio?ieai aaiinoac?i-a?aie oa ia?ea??a AON aei aeinyaiaiiy ieie iaaaoeaieo cia/aiue. Iiaiia?iaeaeaiei a?ae iaoa??a c AON i?e iiaeeeaino? i?iaiaeeoe ?io-iieia?/i? oa aaiinoac?ieia?/i? ianoaaeaiiy. C iaoith i?io?eaeoeee ? e?eo-aaiiy ?aeiiaiaeo?oueny ei?aeoe?y aeyaeaieo ii?ooaiue, a oaeiae aeeniaina?iee iaaeyae iaae?ao?a. NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? Eioaeoieiaey a aeooa?noaa e aeiaeieiaee / Iiae ?aae.i?io.*aeee A.E.– Aeiiaoee, 1998. – N.97-131. (Niaao. Eioaiei A.A., *a?iiuo N.A., Aioiiiaa I.E.). I?eiaiaiea ieaciaoa?aca a ?aaaeeeoaoeee e eiiieaeniie oa?aiee i?eau/iiai iaauiaoeaaiey aa?aiaiiinoe, iaoneiaeaiiiai eiioiieiae/aneei eiioeeeoii ?acee/iiai aaiaca // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee. – 1996.– O.1, ? 1.– N.51-55. Iiuo eniieueciaaiey eiiaeie?iaaiiiai ieceieioaineaiiai eaca?iiai eceo/aiey a ?aaaeeeoaoeee aeaiuei n ia?ooaieai aaia?aoeaiie ooieoeee // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee.– 1997.– O.2, ? 1.– N. 48-51. Iaoiaeu a?aaeoaoeeiiiie oe?o?aee e?iae a i?ioeeaeoeea e ea/aiee aiieii-naioe/aneeo caaieaaaiee (ANC) a aeooa?noaa e aeiaeieiaee // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee. – 1997. – O.2, ? 2.– N. 121-126. (Niaao. *a?iiuo N.A, Iiaeeaaeeia E.A., AEo?aaea A.A.). ?ieue aeiioeca?ii-oe?aieaeiie nenoaiu o aieueiuo n ia?ooaieai ?ai?iaeoeoeaiie ooieoeee // A?o. eeei. yeni. iaae. – 1997.– O.6, ? 1.– N. 45-48. Iniaaiiinoe iae?iaoii?aeueiuo e ineoiaaaaoaoeaiuo ia?ooaiee o iaoeeaioie n i?eau/iui iaauiaoeaaieai aa?aiaiiinoe a aiaiiaca // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.– 1998. – ? 12.– N. 4-13. Ninoiyiea ooieoeee oaoiieaoeaioa?iiai eiiieaena i?e aioeoinoieeieaeiii neiae?iia // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee.– 1998.– O.3, ? 1.– N. 10-14. Eeeieei-eiioiieiae/aneea iniaaiiinoe aaeaioaoeee iiai?iaeaeaiiuo, ?iaeeaoeony io iaoa?ae n i?eau/iui iaauiaoeaaieai // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.– 1998.– ? 13. – N. 9-14. Aaeoa?eaeueiue aaaeiic a nia?aiaiiuo aeooa?noaa e aeiaeieiaee // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee.– 1998.– O.3, ? 2.– N. 69-79. (Niaao. sseiaeaaa Y.A., Ieeeiaiei I.I.). No/ania i?io?eaeoeea oa e?eoaaiiy cae/iiai iaaeiiooaaiiy aaa?oiino? c aeei?enoaiiyi ieaciaoa?aco // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.– 1999.– ? 1.– N. 88-90. Iniaaiiinoe eiioiieiae/aneie ?aaeoeaiinoe o iaoeeaioie n iaauiaoeaaieai aa?aiaiiinoe aooieiioiiiai aaiaca // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1999. – ? 6.– N. 18-21. Ecinaineaeeecaoeey oaoaeueiuie aioeaaiaie a nenoaia iaoue-ieiae i?e i?eau/iii iaauiaoeaaiee // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1999. –? 7.– N. 4-7. ?ieue iaaeeei-nioeeaeueiuo oaeoi?ia a iaoiaaiaca iaauiaoeaaiey aa?aiaiiinoe // Aanoiee yieaeaieieiaee e aeaeaiu. – 1999. – O.3, ? 2. – N. 140-143. I?ioeeaeoeea ineiaeiaiee aa?aiaiiinoe o aeaiuei n i?eau/iui iaauiaoeaaieai aa?aiaiiinoe i?e aioeoinoieeieaeiii neiae?iia // Aanoiee yieaeaieieiaee e aeaeaiu. – 1999. – O. 3, ? 1. – N. 195-199. Iniaeeaino? aaeaioaoe?? iiaiia?iaeaeaieo, ye? ia?iaeeeeny oeyoii eana?aaiai ?icoeio a?ae iaoa??a ?c cae/iei iaaeiiooaaiiyi aaa?oiino? // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1999. – ? 8.– N. 16-18. Nia?aiaiiua aniaeou oa?iaeioa?aiee iaauiaoeaaiey aa?aiaiiinoe // Oa?iaeieia?/iee a?niee. – 1999. – ? 2. – N. 52-54. I?eiaiaiea eioa?oa?iia a aeooa?noaa e aeiaeieiaee // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1999. – ? 12.– N. 11-17. (Niaao. Aaiieeiaa O.A.). A.n. 1733002 NNN?, IEE A61E39/395. Niinia ea/aiey oa?icu i?a?uaaiey aa?aiaiiinoe / ? 4472632; Cayae. 08.09.89; Iioae. 15.05.92., Athe. ? 18. – 4 n. (Ni?aaao. Nioei A.A., Eoeee A.N.). Iao. 25676A Oe?a?ia, IIE A61E31/445, 31/55, 311/557, 37/34. Niin?a aaaeaiiy iieia?a i?e aeeneii?aeeiiaai?e iieiaia?e ae?yeueiino? / ? 97105029; Cayae. 14.10.97; Iioae. 30.10.98, Athe.–1999.– ? 1.– 3 n. (Ni?aaao. *aeea A.E., Eaaoaiei A.I., sseiaeaaa A.A.). Iao. 25666A Oe?a?ia, IIE A61I1/38, A61E31/00, 33/26, 37/04, 37/40. Niin?a i?aeaioiaee aaa?oii? aei iieia?a / ?98041663; Cayae. 01.04.98; Iioae. 30.10.98; Athe.–1999.– ? 1.– 3 n. Oniaoe e i?iaeaiu a aeeaaiinoeea e ea/aiee aioeoinoieeieaeiiai neiae?iia a aeooa?neie i?aeoeea // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee. – 1998. – O. 3, ? 1. – N. 62-71. Ninoiyiea ?ai?iaeoeoeaiie nenoaiu o aieueiuo n ia?ooaieai ooieoeee ueoiaeaeiie aeaeacu // Aanoiee iiauo iaaeeoeeineeo oaoiieiaee. – 1998. – O.5, ? 2. – N. 45-48. I?iaeo ?ai?aaiecaoeee aeooa?nei-aeiaeieiae/aneie neoaeau ii ieacaieth ieaiiaie e yeno?aiiie ea/aaii-i?ioeeaeoe/aneie iiiiue ?iaeianiiiiaaoaeueiui o/?aaeaeaieyi Aeiiaoeeie iaeanoe// Iaaeeei-nioeeaeueiua i?iaeaiu naiuee. – 1997. – O. 2, ? 1. – N. 88-91. (Niaao. *aeea A.E., sseiaeaaa Y.A., Eaaoaiei A.I., Eoa?ae E.A., Iiaeeaaeeia E.A.). Aeeyiea iai?a?uaiiai iaia?aiiiai ieaciaoa?aca ia eiioiiaaiinoaceieiae/aneea acaeiiioiioaiey o aa?aiaiiuo n IIA-aanoicii// Iaaeeei-nioeeaeueiua i?iaeaiu naiuee.– 1998.– O.3, ?2. – N. 24-28. (Niaao. *aeea A.E., ?acie/aiei I.A.). Iiaee iaoiae i?iaiicoaaiiy oa eiio?ieth i?e e?eoaaii? iaaeiiooaaiiy aaa?oiino? / Iaaeiiooaaiiy aaa?oiino?: Ca.iaoe.i?. – Ee?a, 1997. – N. 116-118. No/ani? i?aeoiaee aei ae?aaiinoeee oa e?eoaaiiy cae/iiai iaaeiiooaaiiy aaa?oiino? / Iaaeiiooaaiiy aaa?oiino?: Ca. iaoe. i?. – Ee?a, 1997. – N. 419-421. (Ni?aaao. *aeea A.E., Eaaoaiei A.I.). Iniaeeaino? aaeaioaoe?? iaiiaeyo, ye? ia?iaeeeeny oeyoii eana?nueeiai ?icoeio a?ae iaoa??a ?c cae/iei iaaeiiooaaiiyi aaa?oiino? a aiaiiac?: Ca. iaoe. i?. – Neioa?iiieue, 1998. – N. 110-113. Aooiaaiio?ainooc?y i?e ieaiiaiio aaaeii?iaeueiiio ?ic?iaeaeaii?: Ca??iee iaoeiaeo i?aoeue. – Neioa?iiieue, 1998. – N. 373-377. (Ni?aaao. *a?iieo N.A., Iiaeeueiae?ia ?.I., ?iaiaa I.I.). Diagnostics and treatment of chlamydia infection in women with preterm labor // Infectious Diseases in Obst. and Gyn. – 1996. – Vol. 4, ? 3. – P. 206-208 (Ni?aaao. Yakovleva I.B.). Anticoagulant lupus type like cause of abortion // Acta Obst. et Gyn. Scandinavica. – 1997. – Vol. 76, S.167:1. – P. 63. Immunological conflict during pregnancy: New approach to diagnosis and treatment// Acta Obst. et Gyn. Scandinavica. – 1997.– Vol. 76, S. 167:5. – P. 78-79. (Ni?aaao. Chaika V.K.). I?eiaiaiea yooa?aioiuo iaoiaeia a ea/aiee aiieii-naioe/aneeo caaieaaaiee a aeiaeieiaee // AEo?iae aeooa?noaa e aeaineeo aieaciae. – 1998. – Niaoe. aui. – N. 189-190. (Niaao. *a?iiuo N.A., Eio?ia E.TH.). AIIOAOe?ss Aeueii?ia O.I. Cae/ia iaaeiiooaaiiy aaa?oiino? ? aioeoinoie?i?aeiee neiae?ii. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe c? niaoe?aeueiino? 14.01.01. aeooa?noai ? a?iaeieia?y. ?inoeooo iaae?ao???, aeooa?-noaa ? a?iaeieia?? Aeaaeai?? iaaee/ieo iaoe Oe?a?ie, Ee?a, 1999 ?. Aeena?oaoe?th i?enay/aii ieoaiiyi ae??oaiiy aaaeeeai? iaaeeei-nioe?a-eueii? i?iaeaie: aaa?oiino? ? iieia?a. A ?iaioo aeeth/aii ee?i?ei-oai?aoe/i? aniaeoe aeieeiaiiy, ?icaeoeo aioeoinoie?i?aeiiai neiae?iio oa eiai aieeao ia ?ai?iaeoeoeaio oa ae?oi?iaeio ooieoe?th ae?iie, a oaeiae ia noai caei?ia’y ?o-i?o ae?oae. I?iaaaeaii nioe?ieia?/ia oa ee?i?ei-noaoenoe/ia ne?ei?iaiaa ianoa-aeaiiy 1127 iaoe??ioie, ui i?iaeeaathoue a ?icaeiooeo i?iieneiaeo ?aa?iiao Aeiiaoeueei? iaeano?. Aecia/aii caeiiii??iino? oa aeyaeaii i?e/eiii-iane?ae-eia? ca’ycee i?ae ??aiai ineoiaiioe?eiiai no?ano oa iayai?noth a e?ia? AA, ??aiai ineoiaiioe?eiiai no?ano ? ?icaeoeii o aaa?oieo oaoiieaoeaioa?ii? iaaeinoaoiino?, ui aeieea? ia oe? iaoi/ii-ieaoeaioa?ii-ieiaeiaiai e?iaiia?-ao oa noi?iaiaeaeo?oueny oneeaaeiaiiyie ia?aa?ao aaa?oiino? ? iieia?a. Cai?i-iiiiaaii iiaee iai?yiie o anoaiiaeaii? i?e/ei ?ae?iiaoe/iiai iaaeiioo-aaiiy aaa?oiino? – ae?aaiinoeea aioeoinoie?i?aeiiai neiae?iio. ?ic?iaeaii eiiieaen i?io?eaeoe/ieo, ?aaa?e?oaoe?eieo oa e?eoaaeueieo caoiae?a o ?ac? ?ioiieiioe?eoii? aaa?oiino?, yeee aeicaiey? cieceoe ieoiio aaao oneeaaeiaiue aaa?oiino?, ia?eiaoaeueii? caoai?thaaiino? oa nia?oiino?. Eeth/ia? neiaa: aioeoinoie?i?aeiee neiae?ii, cae/ia iaaeiiooaaiiy aaa?oiino?, ?ioiiee eiioe?eo, ?aaa?e?oaoe?y, ae?aaiinoeea, e?eoaaiiy, i?io?-eaeoeea. AIIIOAOeEss Aeaieia O.I. I?eau/iia iaauiaoeaaiea aa?aiaiiinoe e aioeoinoieeieaeiue neiae?ii. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01. – aeooa?noai e aeiaeieiaey. – Einoeooo iaaeeao?ee, aeooa?noaa e aeiaeieiaee Aeaaeaiee iaaeeoeeineeo iaoe Oe?aeiu, Eeaa, 1999 a. Aeenna?oaoeey iinayuaia aii?inai aaaeiie iaaeeei-nioeeaeueiie i?iaeaiu: aa?aiaiiinoe e ?iaeia o aeaiuei n eaeeiiaoe/aneei iaauiaoeaaieai e niaea?aeeo eeeieei-oai?aoe/aneea aniaeou aicieeiiaaiey, ?acaeoey aioeoinoieeieaeiiai neiae?iia e aai aeeyiey ia ?ai?iaeoeoeaioth e aeaoi?iaeioth ooieoeeth aeaiuei, a oaeaea ia ninoiyiea caei?iauey eo aeaoae. I?iaaaeaii nioeeieiae/aneia e eeeieei-noaoenoe/aneia ne?eieiaiaia ianeaaeiaaiea 1127 iaoeeaioie, i?iaeeaathueo a ?acaeouo i?iiuoeaiiuo ?aaeiiao Aeiiaoeeie iaeanoe. Aeaiiua enneaaeiaaiey iieacaee, /oi a 37,3 % yoeieiaey i?eau/iiai iaauiaoeaaiey aa?aiaiiinoe auea iaoneiaeaia iaee/eai o iaoeeaioie aioeoinoieeieaeiuo aooiaioeoae. I?e oaeoaeaiiii ianeaaeiaaiee aeaiuei yoie eaoaai?ee auyaeaia iiauoaiiay /anoioa o?iie/aneie aaeoa?eaeueiie e ae?oniie eioaeoeee, o eaaeaeie o?aoueae ioia/aeanue iieeaaeaioiay aeea?aey (32,1 %). Ec aeiaeieiae/aneeo caaieaaaiee ia ia?aii ianoa auee o?iie/aneea ?aoeeaeeae?othuea aaeiaeneou (44,3 %), o?iaaieoaeueiay eioaeoeey (20,8 %), aa?iaoe/aneay eioaeoeey iaaethaeaeanue a 34,3% neo/aaa. Iaeaieaa /anouie ineiaeiaieyie aa?aiaiiinoe auee: ?aoeeaeeae?othuay oa?ica i?a?uaaiey aa?aiaiiinoe (48,9 %), aanoic II iieiaeiu aa?aiaiiinoe (16,7 %), neiae?ii caaea?aeee aioo?eoo?iaiiai ?acaeoey ieiaea (33,3 %), oaoiieaoeaioa?iay iaaeinoaoi/iinoue (88,9 %). I?e ioeaiea ninoiyiey caei?iauey iiai?iaeaeaiiuo ioia/aia neaaeothuay no?oeoo?a caaieaaaaiinoe a ?aiiai iaiiaoaeueiii ia?eiaea: aeiio?ioey (33,3%), ia?ooaiea iicaiaiai e?iaiia?auaiey (48,5 %), neiae?ii aeuoaoaeueiuo ?anno?ienoa (30,3 %). Aeeaaiinoeea aioeoinoieeieaeiiai neiae?iia aeeth/aea na?ieiae/aneia ii?aaeaeaiea niaoeeoe/aneeo aioeoinoieeieaeiuo aioeoae, a oaeaea ii?aaeaeaiea eaieeiiaiai a?aiaie a ni/aoaiee n eeeie/aneeie i?eciaeaie: ia?eiaoaeueiua iioa?ie ?acee/iiai n?iea aanoaoeee e o?iiaicu aai e a?oa?ee ethaie eieaeecaoeee. I?e ianeaaeiaaiee iauaai eiioiiiai noaoona auyaeaii, /oi aia aa?aiaiiinoe o iaoeeaioie n aioeoinoieeieaeiuie aioeoaeaie eiathony i?eciaee ia?ooaiey eiioiieiae/aneiai aiiainoaca ii oeio aoi?e/iiai eiioiiaeaoeoeeoa, n ianooieaieai aa?aiaiiinoe eciaiaiey eiioiiiai noaoona iiaeii ?anoeaieoue eae oneeaiiue oei eiioiiiai ioaaoa aac aeinoaoi/iie eiioiinoi?annee, oa?aeoa?iie aeey oeceieiae/aneie aa?aiaiiinoe. I?e eco/aiee ai?iiiaeueiiai i?ioeey iaoeeaioie n AON ia auyaeaii aeinoiaa?iuo eciaiaiee, iaeiaei niaea?aeaiea ai?iiiia e iaaeeaoi?ia no?anna auei iiauoaii ia 30-40 % ii n?aaiaieth n ii?iie, /oi oeacuaaei ia au?aaeaiiia ineoiyiioeeiiaeueiia iai?yaeaiea. Iaaethaeaeanue oaniay ei??aeyoeeiiiay caaeneiinoue iaaeaeo noaiaiueth ineoiyiioeeiiaeueiiai iai?yaeaiey e iieacaoaeyie aaiinoaca, eiioiieiae/aneie ?aaeoeaiinoe e ninoiyieai ?ai?iaeoeoeaiie ooieoeee. Ii?aaeaeaiu caeiiiia?iinoe ?acaeoey e auyaeaiu i?e/eiii-neaaenoaaiiua nayce iaaeaeo iaee/eai AON e o?iaiai ia?eiaoaeueiuo iioa?ue, ?acee/iuo aeooa?neeo ineiaeiaiee aneaaenoaea ?acaeoey aaiinoaceieiae/aneeo ia?ooaiee nenoaiiiai oa?aeoa?a, a iniiaa eioi?uo eaaeeo aooieiioiiue i?ioeann, eioi?ue n ianooieaieai aa?aiaiiinoe aeoeaece?oaony. Aicieeatho ia?ooaiey iaoi/ii-ieaoeaioa?iiai e?iaiia?auaiey n ?acaeoeai OII, yiaeie?eiiie e o?ioe/aneie ooieoeee ieaoeaiou, nii?iaiaeaeathueany ineiaeiaieyie oa/aiey aa?aiaiiinoe aieioue aei ianooieaiey aa i?a?uaaiey e aioo?eoo?iaiie aeaaee ieiaea. I?aaeeiaeaii iiaia iai?aaeaiea a onoaiiaeaiee i?e/ei eaeeiiaoe/aneiai iaauiaoeaaiey aa?aiaiiinoe – aeeaaiinoeea aioeoinoieeieaeiiai neiae?iia. ?ac?aaioai eiiieaen i?ioeeaeoe/aneeo, ?aaaeeeoaoeeiiiuo e ea/aaiuo ia?ii?eyoee a neo/aa eiioiieiioeeeoiie aa?aiaiiinoe, eioi?ue aeaao aiciiaeiinoue nieceoue oaeaeueiue aan ineiaeiaiiie aa?aiaiiinoe, ia?eiaoaeueiie caaieaaaaiinoe e nia?oiinoe. Eeth/aaua neiaa: aioeoinoieeieaeiue neiae?ii, i?eau/iia iaauiaoeaaiea aa?aiaiiinoe, eiioiiue eiioeeeo, ?aaaeeeoaoeey, aeeaaiinoeea, ea/aiea, i?ioeeaeoeea. SUMMARY Dyomina T. N Habitual incomplete pregnancy and Antiphospholipid Syndrome. – Manuscript. Thesis for a doctor’s degree of medicine according to speciality 14.01.01. – Obstetrics and Gynecology. – Institute of Pediatry, Obstetrics and Gynecology of the Academy of medical sciences of Ukraine, Kiev, 1999. The thesis is devoted to solution of the important medical and social problem – pregnancy and labor of the women with ideopathic unbearance and includes clinical and theoretic aspects of the appearance, development of antiphospholipid syndrome and its influence to the reproductive and genital functions of women and also to the health condition of their children. It has been conducted the social, clinical and statistic screening investigation of 1127 women patients living in the industry developed Donetsk region. There have been revealed the dependences, causal and consequent relationships between the rate of psychoemotional stress and the presence of lupus anticoagulant in the blood, the level of psychoemotional stress and development at pregnant women of fetoplacental incompetence arising on the background of utterusplacentafetus circulation of the blood, endocrine and trophic function of placenta, that are accompanied by complications of the pregnancy and labor course. It has been suggested a new direction in the establishment of reasons of idiopathic unbearable pregnancy is a diagnostics of antiphospholipid syndrome. A complex of prophilactic, rehabilitation and medical measures is worked out for a case of immunoconflict pregnancy that gives possibility to reduce the rate of complicated pregnancy, perinatal sickness rate and mortality. Key words: antiphospholipid syndrome, unbearable pregnancy, immune conflict, rehabilitation, diagnostics, treatment, prophilaxis. IA?AE?E OIIAIEO IICIA*AIUe AEEA – aioeea?ae?ie?i?iia? aioeo?ea AEOA – aae?aiiei?oeeio?iiiee ai?iii AIAO – aeueoa2-i?e?iaeiaoe?i oa?oeeueiino? AOEA – aioeoinoie?i?aei? aioeo?ea AON – aioeoinoie?i?aeiee neiae?ii A*O* – aeoeaiaaiee /anoeiai o?iiaiieanoeiiaee /an AA – aia/aeiaee aioeeiaaoeyio AAA – aeaeo?iaioeaoaeia?aia A2 – ano?aae?ie A3 – ano??ie CIA – cae/ia iaaeiiooaaiiy aaa?oiino? C?I – cao?eiea ?icaeoeo ieiaea E – ei?oecie I – i?iaanoa?ii IAIA – ieaoeaioa?iee aeueoa1-i?e?iaeiaoe?i IAI – ineoiaiioe?eia iai?oaa IE – ieaoeaioa?iee eaeoiaai IIE – ii?ooaiiy iiceiaiai e?iaiia?ao NAe? – neiae?ii aeeoaeueieo ?iceaae?a OAA – o?ioiaeanoe/iee aaoa1-aeiaoe?i OOA – oe?aio?iiiee ai?iii O3 – o?eeiaeoe?ii?i O4 – oe?ienei OII – oaoiieaoeaioa?ia iaaeinoaoi?noue Oe?E – oee?eoethth/? ?ioii? eiiieaene OeIA – oeeoiiaaaeia??on ?io? nei?i/aiiy aaaaeathoueny caaaeueiiaaeeaaieie.

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