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Зміни синовіоцитограми, фунціональної активності нейтрофілів і лімфоцитів при асептичних артритах у телят (клініко-експериментальні дослідження): Авто

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A?eioea?e?anueeee aea?aeaaiee aa?a?iee oi?aa?neoao

*A?IssE Na?a?e Aieiaeeie?iae/

OAeE
619:617. 3 636.2.053

Ci?ie neiia?ioeeoia?aie, ooieoe?iiaeueii? aeoeaiino? iaeo?io?e?a ?
e?ioioeeo?a i?e anaioe/ieo a?o?eoao o oaeyo (ee?i?ei-aenia?eiaioaeuei?
aeine?aeaeaiiy)

16.00.05 – aaoa?eia?ia o??o?a?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa aaoa?eia?ieo iaoe

A?ea Oea?eaa – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a A?eioea?e?anueeiio aea?aeaaiiio aa?a?iiio oi?aa?neoao?

Iaoeiaee ea??aiee aeieoi? aaoa?eia?ieo iaoe, i?ioani? ?caeainueeee
A?oae?e Eineiiae/, Iieoaanueeee aea?aeaaiee n?euenueeiainiiaea?nueeee
?inoeooo, caa?aeoaa/ eaoaae?e o??o?a?? oa aeooa?noaa

Io?oe?ei? iiiiaioe:

aeieoi? aaoa?eia?ieo iaoe, i?ia?aeiee iaoeiaee ni?a?ia?oiee,Ieaenaiae?
Aai?a?eiae/, ?inoeooo ciieia?? ?i. Oiaeueaaocaia IAI Oe?a?ie.

eaiaeeaeao aaoa?eia?ieo iaoe, aeioeaio Nooiiin A?eoi? Iao?iae/,
Iaoe?iiaeueiee aa?a?iee oi?aa?neoao, eaoaae?a oe?o?a??.

I?ia?aeia onoaiiaa

Eo?nueea aea?aeaaia n?euenueeiainiiaea?nueea aeaaeai?y ?in?enueei?
Oaaea?aoe??, eaoaae?a o??o?a??, i. Eo?nuee

Caoeno aeena?oaoe?? a?aeaoaeaoueny “24.06 ” 1999 ?. i 15.00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 27.821.02 i?e
A?eioea?e?anueeiio aea?aeaaiiio aa?a?iiio oi?aa?neoao? ca aae?anith:
256400 , Ee?anueea iae., i. A?ea Oea?eaa, aoe. Noaaeuainueea, 126;
iaa/aeueiee ei?ion ? 5 , aoae.?1.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? A?eioea?e?anueeiai
aea?aeaaiiai aa?a?iiai oi?aa?neoaoo: i.A?ea Oea?eaa , Niai?ia ieiua ,
8/1

Aaoi?aoa?ao ?ic?neaiee “21” o?aaiy 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao aaoa?eia?ieo iaoe
I.I.Noaaeiee

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. O eieaeoeaieo ainiiaea?noaao cia/iiai iioe?aiiy
na?aae iiaie?ay aaeeei? ?iaaoi? ooaeiae inoaii?i /anii iaaoee oai?iae
iii?ii-?ooiaiai aia?aoo (Naiaiia A.N., 1981, 1983, 1985; Ai?en?ae/ A.A.,
1990, 1991;Iae?oaanueeee E.A, 1991; ?aeaeea E.A, 1991; Eaeaoi?e ?.A,
1991; Iaiueei ?.N, 1993; Iaiueei ?.N., Noaaeiee I.I., 1995; ?oaeaiei
N.A., 1997), na?aae yeeo cia/ia i?noea iin?aeathoue a?o?eoe
?ioaeoe?eiiai oa ia?ioaeoe?eiiai iioiaeaeaiiy. Caeaaeii a?ae oiia
oo?eiaiiy, caoai?thaai?noue ia a?o?eo iiaea noaiiaeoe a?ae 6 aei 11,2%
(Naiaiia A.N., 1985). I?e/eiaie caoai?thaaiue caeaa?eueoiai aaaaeathoue
aenieee ??aaiue o?aaiaoecio, iniaeeai i?e oo?eiaii? oaa?ei ia i?aeeic? c
oaa?aeei iie?eooyi, nainea?e?caoe?th i?aai?cio aiane?aeie cia/iiai
aioeaaiiiai iaaaioaaeaiiy oa cieaeaiiy ?ioiieia?/ii? ?aaeoeaiino?
i?aai?cio (Naiaiia A.N., 1985; ?oaeaiei N.A., 1997).

Ioaea, a?o?eoe o aaeeei? ?iaaoi? ooaeiae ? aeooaeueiith i?iaeaiith
no/aniiai neioa?noaa. Oni?o o ae??oaii? oeueiai ieoaiiy cia/iith i??ith
caeaaeeoue a?ae ciaiiy iaoai?ci?a ?icaeoeo oa ia?aa?ao a?o?eo?a.

Aei aea/aiiy iaoiaaiaco a?o?eo?a o oaa?ei aoea i?eaa?iooa oaaaa
aaaaoueio aeine?aeiee?a. Oea aeicaieeei aecia/eoe ii?oieia?/i?
iniaeeaino? noaeiaiai? iaoieia??, ci?ie neiia?aeueii? ??aeeie (Eoci?oeia
A.N., 1955 ; Iaoa??a A.I., 1968; Oeoiithe E.A., 1985; ?caeainueeee A.E.,
1993; ?oaeaiei N.A., 1997; *i?iicoa I.I., 1998). Aea caeeoathoueny
iaaeinoaoiuei aea/aieie ee?oeiiee neeaae neiia?aeueii? ??aeeie,
oa?iaioaoeaii-aia?aaoe/ia aeoeai?noue eaeeioeeo?a, ?ioiieia?/i? oaeoi?e
caoenoo oa ?ioa .

Caycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeany ca?aeii c eaoaae?aeueiith oaiaoeeith iaoeiai-aeine?aeii?
?iaioe.

Iaoa ?iaioe.Iaoith aeine?aeaeaiiy aoei aea/aiiy neiia?ioeeoia?aie oa
ooieoe?iiaeueii? aeoeaiino? iaeo?io?e?a ? e?ioioeeo?a i?e anaioe/ieo
a?o?eoao ? ?ic?iaea iaoiaaiaoe/ii iaa?oioiaaieo iaoiae?a e?eoaaiiy
a?o?eo?a.

Aeey aeinyaiaiiy iaoe iaiao?aeii aoei ae??oeoe ianooii? caaaeaiiy:

· aea/eoe ee?oeiiee neeaae neiia?aeueii? ??aeeie a ii?i? oa a aeeiai?oe?
anaioe/ieo a?o?eo?a o iieiaeiyeo aaeeei? ?iaaoi? ooaeiae;

· aea/eoe oa?iaioaoeaii-aia?aaoe/io nenoaio eaeeioeeo?a ia?eoa?e/ii?
e?ia? oa neiia?aeueii? ??aeeie a ii?i? oa i?e anaioe/ieo a?o?eoao;

· aea/eoe aeaye? oaeoi?e ?ioiiiai caoenoo i?aai?cio a ii?i? oa a
iaoiaaiac? anaioe/ieo a?o?eo?a (O-? A-e?ioioeeoe oa oee?eoethth/? ?ioii?
eiiieaene);

· ii?aoethaaiiy aeayeeo iaoiae?a e?eoaaiiy i?e anaioe/ieo a?o?eoao o
iieiaeiyeo aaeeei? ?iaaoi? ooaeiae c aeei?enoaiiyi i?aia?ao?a
i?ioecaiaeueii?, ?ioiinoeioethth/i? oa aeanainea?e?coth/i? ae??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Ia iniia? aea/aiiy aeeiai?ee
ee?oeiiiai neeaaeo neiia?aeueii? ??aeeie, oa?iaioaoeaiiaia?aaoe/ii?
aeoeaiino? eaeeioeeo?a neiia?aeueii? ??aeeie oa e?ia?, ai?noo Oe?E
?ice?eo? iia? iaoai?cie iaoiaaiaco anaioe/ieo a?o?eo?a o iieiaeiyeo
aaeeei? ?iaaoi? ooaeiae, ui aeaei ciiao aenia?eiaioaeueii ? oai?aoe/ii
iaa?oiooaaoe aoaeoeaiee iaoiae e?eoaaiiy oai?eo ia a?o?eo oaa?ei
aioo??oiueinoaeiaiaeie ?i?eoe?yie 1015 ie 25%-iiai ?ic/eio aeeiaeneaeo,
i?eaioiaeaiiai ia 0,5 %iiio ?ic/ei? iao?ii?aeacieo.

I?aeoe/ia cia/aiiy aeeiiaii? ?iaioe iieyaa? a oiio, ui anoaiiaeai?
ii?iaoeae neiia?ioeeoia?aie oa iieaciee?a oa?iaioaoeaiiaia?aaoe/ii?
aeoeaiino? eaeeioeeo?a o ee?i?/ii caei?iaiai iieiaeiyeo 46-i?ny/iiai
a?eo, ye? iiaeooue aooe iniiaith aeey iiaeaeueoiai aea/aiiy ??cieo
iaoieia?/ieo i?ioean?a o noaeiaao. Anoaiiaeai? ci?ie oeeo iieaciee?a o
i?ioean? ?icaeoeo a?o?eo?a oa i?ae /an e?eoaaiiy iiaeia aeei?enoiaoaaoe
aeey iinoaiiaee ae?aaiico oa aeey eiio?ieth ca aoaeoeai?noth oa?ai??.

?ic?iaeaiee, ai?iaiaaiee ? ai?iaaaeaeaiee o i?aeoeeo aoaeoeaiee iaoiae
e?eoaaiiy anaioe/iiai a?o?eoo oeyoii aioo??oiueinoaeiaiaiai aaaaeaiiy
1015 ie 25%-ai ?ic/eio aeeiaeneaeo, i?eaioiaeaiiai ia 0,5% -iiio ?ic/ei?
iao?ii?aeacieo.

Iaea?aeai? ?acoeueoaoe aeei?enoiaothoueny i?e /eoaii? eaeoe?e oa
i?iaaaeaii? eaai?aoi?ii-i?aeoe/ieo caiyoue c o??o?a?? ia oaeoeueoaoao
aaoa?eia?ii? iaaeeoeeie A?eioea?e?anueeiai AeAO, IAO, Iieoaanueeiai
aea?aeaaiiai n?euenueeiainiiaea?nueeiai ?inoeoooo, a ?inoeooo?
i?neyaeeieiiiiai iaa/aiiy ea??aiee?a ? niaoe?ae?no?a aaoa?eia?ii?
iaaeeoeeie i?e AAeAO, a oaeiae i?e e?eoaaii? oaa?ei a ainiiaea?noaao
Ee?anueei? oa E??iaia?aaenueei? iaeanoae.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aeeiiaiee aanue ianya
aenia?eiaioaeueieo aeine?aeaeaiue, c?iaeaii aiae?c oa ocaaaeueiaiiy
iaea?aeaieo ?acoeueoao?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue
aeiiia?aeaeeny oa iaaiai?thaaeeny ia ui??/ieo iaoeiai-i?aeoe/ieo
eiioa?aioe?yo i?ioani?nueei-aeeeaaeaoeueeiai neeaaeo A?eioea?e?anueeiai
AeAO, ia i?aeia?iaei?e eiioa?aioe?? iieiaeeo o/aieo (i.Oa?e?a, 12 ea?oiy
1997 ?.), iaoeiaiiaoiaee/iiio nai?ia?? (i.??aia, 56 ethoiai 1998 ?.) oa
??e i?aeia?iaei?e eiioa?aioe?? c i?iaeai ia?ioaeoe?eii? iaoieia?? oaa?ei
(i.A?ea Oea?eaa, 45 /a?aiy 1998 ?.).

Ioae?eaoe??. ?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue iioae?eiaai?
o 4 noaooyo , ui aeeoee o “A?nieeo A?eioea?e?anueeiai aea?aeaaiiai
aa?a?iiai oi?aa?neoaoo” 3 oa ca??ieeo “Eaai?aoi?ia aaoa?eia?ia
iaaeeoeeia” 1 ? a iaoa??aeao eiioa?aioe?? 1.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?eia ?iaioa neeaaea?oueny c?
anooio, iaeyaeo e?oa?aoo?e, aeeeaaeaiiy ?acoeueoao?a aeanieo
aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiue, aeniiae?a oa
i?aeoe/ieo i?iiiceoe?e, nieneo aeei?enoaieo e?oa?aoo?ieo aeaea?ae.
?iaioa aeeeaaeaia ia 158 noi??ieao iaoeiiieniiai oaenoo, ?ethno?iaaia 18
oaaeeoeyie oa 8 ?enoieaie. Nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae
neeaaea?oueny c 303 iaeiaioaaiue, o oiio /ene? 83 ?iicaiieo.

AEA?? IAI?ssIE?A AeINE?AeAEAIIss, IAOA??AE OA IAOIAeE AEEIIAIIss ?IAIOE.

Aeine?aeaeaiiy aeeiioaaeenue o ENI “Iaye” oa ?i. Aaooo?ia Ee?anueei?
iaeano?, iaa/aeueii-aeine?aeiiio ainiiaea?noa? oa ia eaoaae?? o??o?a??
A?eioea?e?anueeiai AeAO. Iaoa??aeii aeey aeeiiaiiy aeena?oaoe?eii?
?iaioe aoee ae/ee /i?ii-?yai? ii?iaee 4–6 – i?ny/iiai a?eo,
nainea?e?ciaai? ne?iaaoeith e?ia? eiiy. A?aeiia?aeii aei iinoaaeaieo
caaaeaiue aoei noi?iiaaii o?e a?oie ee?i?/ii caei?iaeo oaa?ei, ii 12
aie?a o eiaei?e.

Nainea?e?caoe?th i?aai?cio i?iaiaeeee ca iaoiaeeeith A.N.Naiaiiaa
(1985). Aeey oeueiai oaa?eiai i?aeoe??ii aaiaeeee na?aeo ne?iaaoeo e?ia?
eiiy ii 20 ie o?e/?, c ?ioa?aaeii o aea? aeiae.

A?o?eoe aeeeeeaee ia 20-e aeaiue i?ney inoaiiuei? nainea?e?coth/i?
?i?eoe?? oeyoii aaaaeaiiy o ii?iaeieio caieaniaaiai noaeiaa 10 ie
20%-iiai ?ic/eio iao??th oei?eaeo c 0,3 ie oa?iaioeiiai? ie??.

Iieacieee neiia?aeueii? ??aeeie ? ia?eoa?e/ii? e?ia? aecia/aee nii/aoeo
o ee?i?/ii caei?iaeo ae/e?a, ia oii? nainea?e?caoe??, a iio?i o oeeo
naieo oaa?ei ia 3-th, 7-o oa 11-o aeiao ia?aa?ao anaioe/iiai a?o?eoo.

O ae?oa?e na??? aeine?ae?a aea/aeany aoaeoeai?noue ??cieo iaoiae?a
e?eoaaiiy. Aeey oeueiai aoei noi?iiaaii aeine?aeio oa eiio?ieueio a?oie
oaa?ei (ii 12 aie?a o eiaei?e) ?c anaioe/ieie a?o?eoaie. Oaa?eiai
aeine?aeii? a?oie i?ney iii?iaeithth/i? ioieoe?? a ii?iaeieio noaeiaa
aaiaeeee 10 15 ie 25%-iiai ?ic/eio aeeiaeneaeo ia 0,5%-iiio ?ic/ei?
iao?ii?aeacieo ia 3-oth aeiao caoai?thaaiiy, a oaa?eiai eiio?ieueii?
a?oie canoiniaoaaee aioo??oiueinoaeiaiaa aaaaeaiiy 125150 ia
a?ae?iei?oeciio aoeaoaoo ia 0,5%-iiio ?ic/ei? iiaiea?io ia 3-oth, a ca
iaiao?aei?noth ? ia 7-o aeiao caoai?thaaiiy.

Ee?i?/ia aeine?aeaeaiiy, aiae?c i?ia e?ia? oa neiia?aeueii? ??aeeie
aeeiioaaee aei ii/aoeo e?eoaaiiy, ia 5-oo ? 8-io aeiao e?eoaaiiy.

A iaio na??yo aeine?aeaeaiue o ia?eoa?e/i?e e?ia? aecia/eee :

– e?euee?noue a?eo?ioeeo?a, eaeeioeeo?a, ??aaiue aaiiaeia?io oa
eaeeia?aio (caaaeueiii?eeiyoeie iaoiaeaie); e?euee?noue O- ? A-
e?ioioeeo?a (ca ?aaeoe??th ?icaoeiooai?aiiy ca Jondob et all; 1972 o
iiaeeo?eaoe?? Ae.E. Iiaeeiaa ? A.?.Iiaeeiai?, 1981); ??aaiue
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) o ne?iaaooe? e?ia? ( ca TH.A
A?ei?ae/ai ? I.?. Aeoa?iaith, 1984); oeeoio?i?/io aeoeai?noue
i??eiia?ieneaeace (III) o iaeo?io?eao (ca iaoiaeii W. Loele, 1936);
oeeoio?i?/io aeoeai?noue ae?eiaaio e?ioioeeoao oa iaeo?io?eao (ca J. Mc.
Manus, 1946 ? R. Hothkiss, 1948).

O neiia?aeuei?e ??aeei? aecia/aee : ee?oeiiee neeaae (ca I.N. Ai?eniaei,
1988); oeeoio?i?/io aeoeai?noue ae?eiaaio o e?ioioeeoao (ca J. Manus,
1946 ? R. Hotchkiss, 1948); ??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a
(ca TH.A. A?ei?ae/ai ? I.?. Aeoa?iaith, 1984).

Ioe?ieo oeeoio?i?/ieo ?aaeoe?e o ee?oeiao i?iaiaeeee ca iaoiaeii Z.
Kaplov (1955), iiaeeo?eiaaiei G.Astaldy, Z.Verda (1957), i?e oeueiio
ia/enethaaee i?ioeaio iiceoeaii ?aaaoth/eo ee?oei ( I?E), iieaciee
oeeoio?i?/ii? aeoeaiino? (IOeAI) a oiiaieo iaeeieoeyo oa na?aaei?e
oeeoio?i?/iee eiao?oe??io (NOeE). C iaoith aeyaeaiiy na?aae eaeeioeeo?a
ee?oei c aenieith /e iecueeith ?ioaineai?noth ?aaeoe?? aeiaeaoeiai aaaee
aeeoa?aioe?eiaaiee oeeoio?i?/iee eiao?oe??io (AeOeE), yeee a?eueoith
i??ith a?aeia?aaea? ?o ?noeiiee iioaioe?ae.

Io?eiaiee oeeo?iaee iaoa??ae ia?iaeaiee ca i?ia?aiaie, neeaaeaieie ?.E.
Nieieiaei (1987).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O AIAE?C

Iniaeeaino? ia?aa?ao anaioe/ieo a?o?eo?a ia oii? nainea?e?caoe?? o
ae/e?a

I?e ee?i?/iiio aeine?aeaeaii? 1432 aie?a aaeeei? ?iaaoi? ooaeiae aoei
aeyaeaii 246 oaa?ei (17,18%) c o??o?a?/ieie caoai?thaaiiyie o ae?eyioe?
e?ioe?aie, o oiio /ene? 49 aie?a (19,9%) c iaoieia??th noaeia?a.
O?aaeaiiy caieaniaaeo noaeia?a cono??/aeenue o 8,54% aeiaaee?a,
ea?iaeueieo – o 3,66%, caiaeaiiy noaeia?a iaeueoey- o 7,72% aeiaaee?a.
Ia?aaaaeii oea aoee anaioe/i? (63,20%) oa ai?ei? (36,80%) a?o?eoe.
Ae?aaiinooaaeenue a?o?eoe ia ??cieo noaae?yo caoai?thaaiiy, oiio
ee?i?/i? iciaee ia?aa?ao oai?iae iienoaaeeny a eiaeiiio eiie?aoiiio
aeiaaeeo, aea oea ia aeaaaei ciiae aea/aoe aeeiai?eo caiaeueiiai
i?ioeano oa ci?i neiia?aeueii? ??aeeie. Oiio iniiai? aeine?aeaeaiiy
i?iaiaeeee ia oaa?eiao c aenia?eiaioaeueii aeeeeeaieie a?o?eoaie.

C ?icaeoeii aenia?eiaioaeueiiai anaioe/iiai a?o?eoo iaea?eueoa
?ioaineai?noue caiaeueii? ?aaeoe?? a?aei?/aeanue ia 3-oth aeiao
caoai?thaaiiy: o oeae /an caaaeueiee noai oaa?ei aoa i?eai?/aiee, aiie
a?eueoa eaaeaee, ei?i i?eeiaee iaioi/a, oaiia?aoo?a o?ea 39,6 40,0 0N,
/anoioa ioeueno 100 110, aeeoaiiy– 27–32 ca 1 oa. O aeeiai?oe?
niinoa??aaee eoeueaaa?noue aenieiai nooiaiy, i?e iaeueiaoe?? o?aaeaiiai
noaeiaa aeyaeyee i?eiooe?noue o?nooaaoi? eiinenoaioe??, aieth/o oa
aa?y/o ia aeioee. Neiia?aeuei? aeai?ioe aeiiaiai?, oeoeoothoue. I?e
ioieoe?? noaeia?a io?eioaaee neiia?th a?ae nieiiyii-aeiaoiai aei
oaiii-aeiaoiai eieuei?o c aeii?oeaie o?a?eio, iaio oyao/o ? eeaeeo,
ii??aiyii c ee?i?/ii caei?iaeie oaa?eiaie.

O e?ia? a?aei?/aee ciaioaiiy e?eueeino? a?eo?ioeeo?a c 6,61 0,49 aei
4,62 0,19 O/e (?0,05) oa ca?eueoaiiy e?eueeino? eaeeioeeo?a c 7,720,45
aei 10,290,56 A/e (?0,001), ??aaiue aaiiaeia?io ciaiooaaany c 105,257,43
aei 78,914,97 a/e (?0,05). A eaeeia?ai? a?aei?/a?oueny i?aeaeuaiiy
i?ioeaioa iaee/eiyaea?ieo iaeo?io?e?a (?0,001) oa cieaeaiiy
naaiaioiyaea?ieo (c 35,500,52 aei 16,760,65%; ?0,001). ?acii c oei
c?inea e?euee?noue iiiioeeo?a oa e?ioioeeo?a a?aeiia?aeii c 1,250,32 aei
4,500,31 (?0,001) oa c 58,630,62 aei 69,310,63% (? 0,001) ? aiceiio?e?a
c 1,310,26 aei 2,250,20% (?0,01).

O neiia?ioeeoia?ai? (oaae. 1) niinoa??aa?oueny ??cea cieaeaiiy
e?eueeino? neiia?ioeeo?a oa ca?eueoaiiy a?no?ioeeo?a, e?ioioeeo?a,
iiiioeeo?a oa iaeo?io?e?a (?0,001).

O iiaeaeueoiio ia 7-o aeiao caoai?thaaiiy caaaeueiee noai o a?eueoino?
oai?eo oaa?ei ?noioii ia ci?ieany, eeoa o 33% oaa?ei a?aei?/aee
eoeueaaa?noue iia?oi? e?ioe?aee na?aaeiueiai nooiaiy oa aeaye? ni?iae
iie?aiiy a noaoeoe?. Ianeai? ?ooe ni?e/eiyee a?eue. I?e iaeueiaoe??
o?aaeaiiai noaeiaa aeyaeyee iacia/io oeoeooaoe?th oa cieaeaiiy
aieth/ino? ? i?noeaai? oaiia?aoo?e, neiia?aeueia ??aeeia aoea aeaui
oyao/?oith (i?ae ia ii/aoeo caoai?thaaiiy), aeiaoiai eieuei?o c eaaeith
iiaeanoeaioe??th.

Oaaeeoey 1

Neiia?ioeeoia?aia oai?eo ia anaioe/iee a?o?eo ae/e?a ia oii?
nainea?e?caoe?? i?aai?cio

Ia??iae aeine?ae-aeaiiyEe?oeie oeaieiiiai iioiaeaeaiiy

Ee?oeie e?ia?Iaeeane-o?eiaai?
ee?oeieNeiia?i-oeeoeA?no?ioeeoee?ioioeeoeiiiioeeoeiaeo?io?eeEe?i?/ii
caei?ia?42,11±0,558,66±0,2443,75±0,721,16±0,101,16±0,143,16±0,10Noai
nai-nea?e?caoe??28,50±0,262,58±0,2960,60±0,452,25±0,230,91±0,125,16±0,21
3-y aeiaa
caoai?tha.6,08±0,1313,08±0,4556,80±0,821,83±0,1015,30±0,616,91±0,427-a
aeiaa caoai?tha.4,16±0,1514,60±0,4261,08±0,472,91±0,1217,25±0,30–11-a
aeiaa
caoai?tha.12,91±0,349,08±0,1567,00±0,281,66±0,109,35±0,17–I?ei?oee: * –
p>0,05 ii??aiyii c ee?i?/ii caei?iaeie oaa?eiaie

Ci?ie ?aooe iieaciee?a a??ia?aei?.

I?e ii?oieia?/iiio aeine?aeaeaii? e?ia? cia/ieo ci?i oaeiae ia
a?aei?/aee. Eaeeia?aia o ae/e?a iaaoaa? aeaeyaeo, oa?aeoa?iiai aeey
anaioe/iiai na?icii-o?a?eiiciiai caiaeaiiy: i?aeaeueany i?ioeaio
naaiaioiyaea?ieo c 16,760,65 aei 30,750,53% oa thieo c 1,180,21 aei
3,50,22% (?0,001) iaeo?io?e?a i?e cieaeaii? i?ioeaioa e?ioioeeo?a c
69,310,63 aei 53,581,10% ? iiiioeeo?a c 4,50,31 aei 3,00,22% (?0,001) oa
ca?eueoaii? e?eueeino? aiceiio?e?a c 2,250,20 aei 3,170,22% (?0,05).

O neiia?ioeeoia?ai? oai?eo ae/e?a a?aei?/a?oueny iiaeaeueoa ca?eueoaiiy
e?eueeino? e?ioioeeo?a, iiiioeeo?a, iaeo?io?e?a, a?no?ioeeo?a oa
ciaioaiiy neiia?ioeeo?a (?0,001.

Ia 11-o aeiao ee?i?/ieo niinoa?aaeaiue a?aei?/aee cia/ia iie?auaiiy
caaaeueiiai noaio oai?eo oaa?ei. O 67% ?c ieo i?ae /an ?ooo niinoa??aaee
eoeueaaa?noue iecueeiai nooiaiy, o noaoeoe? oai?a e?ioe?aea /anoeiai
a?aea o/anoue a iii??. Ia?i noaeia?a ciaioeany, ?o eiioo?e noaee a?eueo
ae?acieie, niinoa??aaeany iacia/ia aieth/?noue oa i?aeaeuaiiy i?noeaai?
oaiia?aoo?e. I?e ?o ioieoe?? aeae?eyeany aeinoaoiy e?euee?noue ??aeei?,
eaeaiooii? neiia??, ui iaea eie?? a?ae aeiaoiai aei na?oei –
ei?e/iaaiai.

O 33% oai?eo oaa?ei o oeae /an aeyaeyee eoeueaaa?noue iia?oi? e?ioe?aee
na?aaeiueiai nooiaiy oa iacia/ia iie?aiiy o noaoeoe?. I?noeaai
a?aei?/aee aeayea ciaioaiiy noaeia?a a ia?i?, ?o eiioo?e aoee iaae?aci?,
i?eiooe?noue u?eueii? eiinenoaioe??, aieth/a. Ia?aaei? aeai?ioe
aeiy/ai?. I?e iaaaioaaeaii? noaeia?a a?ae/oaaee o?one?o, coiiaeaiee
iaoa?oaaiiyi o?a?eio.

O oeae /an niinoa??aaeany oaiaeaioe?y aei ca?eueoaiiy e?eueeino?
a?eo?ioeeo?a, eaeeioeeo?a ? ??aiy aaiiaeia?io ii??aiyii c 7-th aeiaith
caoai?thaaiiy. O eaeeia?ai? na?aae iaeo?io?e?a a?aei?/a?oueny
oaiaeaioe?y aei cieaeaiiy e?eueeino? iaee/eiyaea?ieo ? thieo
iaeo?io?e?a(?0,05) oa a??ia?aeia ciaioaiiy e?eueeino? naaiaioiyaea?ieo
oi?i (?0,001), a e?euee?noue e?ioioeeo?a i?aeaeueeany c 53,581,1 aei
61,000,53% (?0,001).

Ioaea, ii?oieia?/i? aeine?aeaeaiiy iieacaee, ui i?e aenia?eiaioaeueii
aeeeeeaieo a?o?eoao ia oii? nainea?e?caoe?? a?aeaoaa?oueny i?eai?/aiiy
a?eo?iiiaoe/ii? ooieoe??, a eaeeia?ai? oa?aeoa?iei ? ca?eueoaiiy
e?eueeino? iieiaeeo oi?i iaeo?io?e?a, e?ioioeeo?a, iiiioeeo?a oa
aiceiio?e?a i?ioyaii onueiai ia??iaeo caoai?thaaiiy.

O neiia?ioeeoia?ai? ia 11-o aeiao caoai?thaaiiy, ii??aiyii c 7-th
aeiaith, niinoa??aa?oueny ca?eueoaiiy e?eueeino? neiia?ioeeo?a ia 8,75%,
e?ioioeeo?a ia 5,92% oa ciaioaiiy e?eueeino? iaeo?io?e?a ia 7,9%,
iiiioeeo?a ia 1,25%, a?no?ioeeo?a ia 5,52%(?0,001).

Ioaea, aeine?aeaeaiiy neiia?ioeeoia?aie iieacaee, ui o ee?i?/ii
caei?iaeo oaa?ei aei neeaaeo neiia?aeueii? ??aeeie aoiaeyoue ee?oeie
e?ia? oa ee?oeie oeaieiiiai iioiaeaeaiiy. C ?icaeoeii caiaeaiiy
e?euee?noue ee?oei e?ia?, iniaeeai iaeo?io?e?a ? e?ioioeeo?a, c?inoa?, a
e?euee?noue neiia?aeueieo ee?oei ciaioo?oueny. ? eeoa ia 11o aeiao
caoai?thaaiiy a?aei?/a?oueny noaa?e?caoe?y a?no?ioeeo?a oa iacia/ia
i?aeaeuaiiy neiia?ioeeo?a.Oiaoi, nainea?e?ciaai? anaioe/i? a?o?eoe
oa?aeoa?ecothoueny oeiiaei e?ioiiae?ioaaaeueiei caiaeaiiyi, yea
ia?aa?aa? ca a?ia?a?a?/iei oeiii.

O iiaeaeueoiio ia 1525-oo aeiao ee?i?/ieo niinoa?aaeaiue o 50% oaa?ei
a?aei?/aee aeia?ee caaaeueiee noai. Aiie iiai?noth iie?aeeny oai?ith
e?ioe?aeith, i?noeaaeo iciae caiaeueii? ?aaeoe?? ia niinoa??aaeiny,
eiioo?e noaeia?a aoee ae?aaeaieie, aea ?o ia?i caeeoaany iacia/ii
ca?eueoaiei, a oeaieie a ae?eyioe? noaeiaa – ou?eueiai?. I?ioa o /anoeie
oaa?ei ua caa??aaeeny iciaee caiaeaiiy oa aeaye? ii?ooaiiy
noaoi-aeeiai?/ii? ooieoe?? oai?i? e?ioe?aee.

O 33% oaa?ei ee?i?/ia iaeoaeoaaiiy ianoaaaei o ia??iae c 25 – ? aei 35 –
? aeiae a?ae ii/aoeo caoai?thaaiiy, a o 17% iacia/io eoeueaaa?noue
iia?oi? e?ioe?aee niinoa??aaee ? ia 45 – oo aeiao.

Ioaea, ca ?acoeueoaoaie i?iaaaeaieo ee?i?/ieo aeine?aeaeaiue iiaeia
c?iaeoe aeniiaie, ui anaioe/iee neiia?o o a?eueoino? oaa?ei (67%)
ia?aa?aa? aeia?iye?nii ? cae?i/o?oueny a?aeiiaeaiiyi ooieoe?? noaeiaa, a
o 33% oaa?ei a?i iiaea oneeaaeithaaoeny ia?aa?oeeoey?iei o?a?iceoii, i?e
yeiio ou?eueith?oueny eainoea noaeiaa, ciaioo?oueny e?euee?noue
neiia?aeueii? ??aeeie ?, ye iane?aeie, ii?ooo?oueny eiai ooieoe?y.

Noai oa?iaioaoeaii-aia?aaoe/ii? aeoeaiino? nenoaie iaeo?io?eueieo
a?aioeioeeo?a ia oii? nainea?e?caoe?? oa i?e anaioe/ieo a?o?eoao o
ae/e?a

C ?icaeoeii nainea?e?caoe?? i?aai?cio a?aeaoaa?oueny i?aeaeuaiiy
aeoeaiino? III o iaeo?io?eao e?ia? ca an?ia oeeoio?i?/ieie iieacieeaie
ia 20% (?0,001), ca aeiyoeii AeOeE, yeee caeeoa?oueny ia ??ai? ee?i?/ii
caei?iaeo oaa?ei (oaae. 2).

Oaaeeoey 2

Ci?ie aeoeaiino? i??eiia?ieneaeace i?e nainea?e?caoe?? oa anaioe/ieo
a?o?eoao o ae/e?a

Ia??iae

aeine?aeaeaiiy I?E (%)IOeAI (oi.iae.)NOeE (oi.iae.)AeOeE
(oi.iae.)Ee?i?/ii caei?ia?72,00±0,93133,0±2,181,33±0,023,04±0,16Noai
nainea?e?caoe??92,00±1,48160,0±4,161,60±0,043,18±0,203-y aeiaa
caoa.94,70±0,37162,2±3,500,62±0,033,58±0,297-a aeiaa
caoa.99,80±0,08208,2±2,652,08±0,027,04±0,4711-a aeiaa
caoa.97,90±0,75193,2±3,881,93±0,037,10±0,66I?ei?oea. * – p>0,05,
ii??aiyii c ee?i?/ii caei?iaeie oaa?eiaie

O oeae /an iieacieee oeeoio?i?/ii? aeoeaiino? ae?eiaaio oaeiae
i?aeaeueeeny (oaae. 3), e??i i?ioeaioa iiceoeaii ?aaaoth/eo ee?oei
(I?E), yeee caeeoeany ia ??ai? ee?i?/ii caei?iaeo oaa?ei, oiaoi
i?aeaeuaiiy aeoeaiino? ae?eiaaio ia oii? nainea?e?caoe?? i?aai?cio
a?aeaoeiny ia ca ?aooiie ca?eueoaiiy e?eueeino? ee?oei, a aiane?aeie
??ceiai caaaa/aiiy ee?oei ae?eiaaiii. I?aeaeuaiiy aeoeaiino?
i??eiia?ieneaeace a?aeaoeiny a ?acoeueoao? c?inoaiiy e?eueeino?
iiceoeaii ?aaaoth/eo ee?oei ? ??aiii??iiai caaaa/aiiyi ?o oa?iaioii.

?icaeoie caiaeaiiy a noaeia? noi?iaiaeaeoaaany cia/iith aeoea?caoe??th
i??eiia?ieneaeace oa ae?eiaaio. Oae, ia 3-th aeiao caoai?thaaiiy
aeoeai?noue III c?inea ia 22%, a ae?eiaaio ia 46% (?0,001); I?E– aeey
ae?eiaaio i?aeaeueany ia 18,2%, a aeey i??eiia?ieneaeace ia 19,5%
(?0,001). O oeae /an niinoa??aaeany oaiaeaioe?y aei ca?eueoaiiy AeOeE ia
0,54 oi.iae (?0,05) aeey i??eiia?ieneaeace ? a??ia?aeia ia 1,37 oi.iae.
(?0,001) – aeey ae?eiaaio.

A iiaeaeueoiio (ia 7-o aeiao caoai?thaaiiy) c ?ioaineo?eaoe??th
i?ioean?a aenoaeaoe??, aeoeai?noue i??eiia?ieneaeace i?iaeiaaeoaaea
c?inoaoe: IOeAI ? NOeE ia 28% , I?E ia 5,1% , AeOeE ia 3,46 oi.iae.(
?0,001).

Io?eiai? aeai? na?ae/aoue, ui c ?icaeoeii oai?iae o oee?eoethth/?e e?ia?
c?inea e?euee?noue iaeo?io?e?a c aenieith aeoeai?noth oa?iaioo. Iaoa
i?eiouaiiy i?aeoaa?aeaeo?oueny i?e ii??aiyii? io?eiaieo aeaieo c
aiaeia?/ieie o ee?i?/ii caei?iaeo oaa?ei, aea a?aei?/a?oueny a??ia?aeia
i?aeaeuaiiy an?o iieaciee?a oeeoio?i?/ii? aeoeaiino? i??eiia?ieneaeace.

Oaaeeoey 3

Ci?ie oeeoio?i?/ii? aeoeaiino? ae?eiaaio iaeo?io?e?a o ae/e?a ia oii?
nainea?e?caoe?? i?aai?cio oa i?e anaioe/ieo a?o?eoao

Ia??iae aeine?aeaeaiiy I?E (%)IOeAI (oi.iae.)NOeE (oi.iae.)AeOeE
(oi.iae.)Ee?i?/ii caei?ia?69,60±0,70101,70±1,251,01±0,011,26±0,04Noai
nainea?e?caoe??69,40±1,44112,60±2,931,12±0,022,39±0,093-y aeiaa
caoa.87,80±0,69149,00±1,551,49±0,012,63±0,067-a aeiaa
caoa.82,10±1,63146,00±3,921,46±0,033,67±0,2111-a aeiaa
caoa.80,40±1,80142,20±4,291,42±0,043,54±0,23

Aea a oeae /an, ii??aiyii c 3-th aeiaith caoai?thaaiiy, niinoa??aaeany
oaiaeaioe?y aei ciaioaiiy aeoeaiino? ae?eiaaio iaeo?io?e?a: IOeAI ? NOeE
ia 2% ( ?0,05) , I?E ia 5,7%, AeOeE ia 28% (?0,001).

Ia 11-o aeiao caoai?thaaiiy a?aei?/aeinue cieaeaiiy
oa?iaioaoeaii-aia?aaoe/ii? aeoeaiino? iaeo?io?e?a ca an?ia
oeeoio?i?/ieie iieacieeaie yea, i/aaeaeii, iiaycaii c aeayeei
aeniaaeaiiyi i??eiia?ieneaeacii? aeoeaiino? oa c ao?aoith aia?aaoe/ieo
caian?a o iaeo?io?eao, ui aoei ni?e/eiaii nainea?e?caoe??th i?aai?cio oa
caiaeueiei i?ioeanii o noaeia?.

Noai aia?aaoe/ii? aeoeaiino? e?ioioeeo?a e?ia? ? neiia?aeueii? ??aeeie
ia oii? nainea?e?caoe?? oa i?e anaioe/ieo a?o?eoao

C ?icaeoeii nainea?e?caoe?? i?aai?cio i?aeaeuo?oueny aeoeai?noue
ae?eiaaio o e?ioioeeoao ye e?ia?, oae ? neiia?aeueii? ??aeeie ca an?ia
eiai oeeoio?i?/ieie iieacieeaie: IOeAI ? NOeE aeey e?ioioeeo?a e?ia?
c?inee ia 13% ( ?0,001) , a aeey e?ioioeeo?a neiia?aeueii? ??aeeie ia
14% ( ?0,001), AeOeE a?aeiia?aeii ia 43% (?0,001) ? ia 18% (?0,001). O
oeae /an niinoa??aaeanue oaiaeaioe?y aei ca?eueoaiiy I?E aeey
e?ioioeeo?a neiia?aeueii? ??aeeie ia 3,6% ( ?0,05), a aeey e?ioioeeo?a
e?ia? a?i caeeoeany ia ??ai? iieaciee?a ee?i?/ii caei?iaeo oaa?ei.Oaeei
/eiii, nainea?e?caoe?y i?aai?cio ni?eyea iaa?iiaaeaeaiith ae?eiaaio a
e?ioioeeoao ia ca ?aooiie c?inoaiiy e?eueeino? ee?oei, a ca ?aooiie
i?aeaeuaiiy aeoeaiino? ae?eiaaio a ieo.

C?inoaiiy oeeoio?i?/ii? aeoeaiino? ae?eiaaio o e?ioioeeoao e?ia?
a?aeaoaaeiny c ?icaeoeii caiaeueiiai i?ioeano o noaeia? oaa?ei. Oae,
AeOeE c??n ia 84% (c 1,350,40 aei 2,490,03 ?0,001) Aiaeii/an AeOeE aeey
e?ioioeeo?a neiia?aeueii? ??aeeie caeeoeany ia iiia?aaeiueiio ??ai?,
iacaaaeath/e ia c?inoaiiy e?eueeino? e?ioioeeo?a, oiaoi aeoeai?noue
iaa?iiaaeaeaiiy ae?eiaaio a ieo caeeoeeany iaci?iiith, ui iiaycaii c
?aaeoeaiei aeeeaeii o ia?eoa?e/ia ?onei c??eeo ee?oei c aenieith
aeoeai?noth ae?eiaaio.

O iiaeaeueoiio ia?aa?ao anaioe/iiai a?o?eoo (ia 7-o aeiao caoai?thaaiiy)
a?aei?/aeiny cieaeaiiy oeeoio?i?/ii? aeoeaiino? ae?eiaaio ca an?ia eiai
iieacieeaie, ca aeiyoeii AeOeE, yeee aeeiai?/ii c?inoaa ye aeey
e?ioioeeo?a e?ia?, oae ? aeey e?ioioeeo?a neiia?aeueii? ??aeeie. Oea,
i/aaeaeii, iiaycaii c iineeaiiyi aioeaaiii? ae?? ia i?aai?ci oaa?ei oa
ae?eiaaiie?cii, ui ca?aa?oueny c iia?aeiieaiiyi S. Mackienicz c
ni?aaao.(1992).

Ia 11-o aeiao caoai?thaaiiy aeoeai?noue ae?eiaaio ??cei c?inea: I?E aeey
e?ioioeeo?a e?ia? ia 10,4% (c 79,901,51 aei 90,300,80; ?0,001) ? ia
6,8% (c 84,400,85 aei 91,200,38; ?0,001) aeey neiia?aeueii? ??aeeie;
AeOeE – a?aeiia?aeii i?aeaeueany ia 33% (c 3,110,19 aei 4,160,19 ?0,001)
? ia 25% (c 2,330,03 aei 2,930,05; ?0,001), a IOeAI ? NOeE a?aeiia?aeii
c?inee ia 15% ? 13%. Oea, ia iaoo aeoieo, iiaycaii c aeai?an??th
ae?eiaaiaco oa ianooiiith a?ia?aeoeaaoe??th e?ioi?aeii? oeaieie
aiane?aeie nainea?e?caoe?? i?aai?cio.

Noai O – ? A – e?ioioeeo?a ia oii? nainea?e?caoe?? oa i?e anaioe/iiio
a?o?eo? o iieiaeiyeo aaeeei? ?iaaoi? ooaeiae

C ?icaeoeii nainea?e?caoe?? i?aai?cio cieaeo?oueny e?euee?noue O- ? A-
e?ioioeeo?a o ia?eoa?e/i?e e?ia?. A?aeiinia e?euee?noue O-e?ioioeeo?a
ciaioeeany c 20,600,42% aei 13,970,71% (?0,001), A – e?ioioeeo?a c
16,83 0,32 aei 6,50 0,55% (?0,001), a aaniethoia – a?aeiia?aeii c
0,920,04 aei 0,610,04 A/e oa c 0,750,03 aei 0,300,02
A/e(?

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