3

I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

Aea?aeaaia i?aei?e?inoai

“Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ii?nueei? iaaeeoeeie”

Ia i?aaao ?oeiieno

Eiiiaaeaiei Ethaeieea Ieeiea?aia

OAeE: 618.1-006-057:656.61.]78:57.083.3.

CANOINOAAIIss ?IOIIIAO?E*IEO IAOIAe?A AeEss AEssAEAIIss IOOEEI
?AI?IAeOEOEAII? NENOAIE O AE?IIE, ssE? I?AOeTHTHOUe IA AIAeIIIO
O?AINII?O?

Niaoe?aeuei?noue 14.01.34 — aa?aoe?eia, eini?/ia oa ii?nueea iaaeeoeeia

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy

iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Iaeana — 1998

?iaioa aeeiiaia ia aac? Oe?a?inueeiai iaoeiai-i?aeoe/iiai ia’?aeiaiiy
“Iaaeeoeeia o?ainii?oo”, eaoaae? ia?eiaoaeueii? iaaeeoeeie, aeeoy/i? oa
i?aee?oeiai? a?iaeieia??, ii?nueei? iaaeeoeeie Iaeanueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo IIC Oe?a?ie.

Iaoeiaee ea??aiee:

Iaoeiaee eiinoeueoaio:

Io?oe?ei? iiiiaioe:

I?ia?aeia onoaiiaa:

aeaaeai?e AII Oe?a?ie, Cane. ae?y/ iaoee oa oaoi?ee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, i?ioani? Eiaaiei Aiaoie?e Ieaenaiae?iae/, aee?aeoi? AeI
“Oe?a?inueeiai IAe? ii?nueei? iaaeeoeeie”

aeieoi? iaaee/ieo iaoe, i?ioani?

Cae?inueeee Ieaenaiae? Ieaen?eiae/, caa?aeoaa/ eaoaae?e ia?eiaoaeueii?
iaaeeoeeie, aeeoy/i? oa i?aee?aeeiai? a?iaeieia?? Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo

Cane. ae?y/ iaoee oa oaoi?ee Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani?
Oaiae?a Ieaen?e Aioiiiae/, caa?aeoaa/ eaoaae?e ii?iaeueii? o?c?ieia??
Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo

eaiaeeaeao iaaee/ieo iaoe Caii?iae/aiei Ai?en Na?a?eiae/, caa?aeoaa/
o??o?a?/iiai a?aeae?eaiiy Oe?a?inueeiai I I I “Iaaeeoeeia
o?ainii?oo”

Iaoe?iiaeueiee iaaee/iee Oi?aa?n?oao ?i. I.I. Aiaiiieueoey, i. Ee?a

Caoeno a?aeaoaeaoueny “18” a?oaeiy 1998 ?ieo i 13 aiaeei? ia can?aeaii?
Niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.617.01 AeI “Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ii?nueei? iaaeeoeeie” ca aae?anith :
270049, i. Iaeana, aoe. Noaeiiaoae?aia, 1.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? AeI “Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ii?nueei? iaaeeoeeie”

Aaoi?aoa?ao ?ic?neaiee “17” aeiaoiy 1998 ?ieo

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe, i?ioani?
?aiaoue?a I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Niiae?aaiiy ia cieaeaiiy caoai?thaaiiy oa
nia?oiino? a?ae ceiye?nieo iooeei nueiaiaei? iia’ycothoueny c
i?io?eaeoeeith ?o aeieeiaiiy ? ?aiiueith ae?aaiinoeeith (TH.A. A?eiaae/
oa ni?aaao., 1991; ?.A. Aea?a, 1991; I.E. Aeaen??aa oa ni?aaao., 1995;
I.I. Aa?ieia, 1996; C.I. Aeoaina?nueea, I.E. A?yioeaaa, O.A. AEa?aeiaa,
1998; ?.A. Eioaiaae/, A.A. Noiaiei, 1998).

Ceiye?ni? iiaiooai?aiiy, ye? aeyaeythoueny ca aeiiiiiaith o?aaeeoe?eieo
ae?aaiinoe/ieo iaoiae?a, o 40-50% aeiaaee?a ? aaia?ae?ciaaieie ( A.?.
Aiaeyaeeia, E.I. Aaneeaanueea, I.I. Iiaaaeeinueeee, 1980; I.?. Ci?eia,
1984; ss.A. Aioiai, A.I. Eineooiaa, 1985; ?.A. Eiia?ia, 1996). I?e
aeyaeaii? ?aea ia ?aii?o aoaiao naiai ?icaeoeo oni?oia eiai e?eoaaiiy
aoei a iiaeeeaei o 80% oai?eo ii??aiyii c 35-40% ia oaia??oi?e /an (A.A.
Oea/iaa oa ni?aaao., 1989; I.E. Aeaen??aa oa ni?aaao., 1995; I.ss.
Aia?ia, 1996; E.?. Ai?iaeiaa, O.?. Oea/oe, I.A. Oo?/ae, 1998). E??i
ceiye?nieo ooai?aiue, o a?iaeieia?/i?e i?aeoeoe? oe?iea
?iciianthaeaeaiiy ia? i?iia iaoee, aiaeiiao??ic, aeia?iye?ni? iooeeie oa
iooeeii? ooai?aiiy y?/iee?a, ye? i?ecaiaeyoue aei ii?ooaiiy
?ai?iaeoeoeaii?, iaino?oaeueii? oa noaoaai? ooieoe?e ae?iee (A.I.
Aaneaeia, 1990; A.I. Caii?iaeai oa ni?aaao., 1994; A.I. No?eaeaeia, A.?.
Aeaaeaeia, I.?. Eiiae?eeia, 1994), iaoiiaeththoue ci?ie naiiii/oooy oa
cieaeaiiy i?aoeacaeaoiino?. O nai?io ?aiiueiio ?icaeoeo oe? i?ioeane
/ano?oa i?io?eathoue aac ee?i?/ii? neiioiiaoeee (I.I. Aeai??ia, I.I.
Nethna?ue, A.?. Eoeaeia oa ni?aaao., 1995), ? iathoue iniiao aeey
iae?ai?caoe?? (A.A.Co?a,1990; A.I.?eueieoeueeee,1996).

Aeei?enoaiiy aiaeineii?/ii? oa oeueo?acaoeiai? ae?aaiinoeee ia caaaeaee
iiaea nai?/anii ae?aaiinooaaoe caoai?thaaiiy (o 10-12%) iaoee ?
i?eaeaoe?a, a o ?yae? aeiaaee?a (29-30%) ia? i?noea aeia?ae?aaiinoeea
(A.I. Aeaieaeia, A.?. Coe?i, 1990), i?e oeueiio aiaeineii?/ia
ae?aaiinoeea ia? ?yae i?ioeiieacaiue ? iaiaaeaiue (A.I. Naaaeue?aa,
1983).

Aeacaia aeua aea? i?aenoaao noaa?aeaeoaaoe, ui ?ic?iaea iaoiae?a
?aiiuei? ae?aaiinoeee caoai?thaaiue ae?ii/eo noaoaaeo i?aai?a iooeeiiiai
iioiaeaeaiiy ? iaeiei c aeooaeueieo iai?yie?a no/anii? a?iaeieia?? oa
iieia?iaeieia??. Ia iaio aaaeeeaa cia/aiiy ia? iiooe aeinoaoiuei
?ioi?iaoeaieo iaoiae?a aecia/aiiy oa ?aiiuei? ae?aaiinoeee iooeei,
?aoeeaeea?a caoai?thaaiiy oa eiio?ieth ca aoaeoeai?noth o??o?a?/iiai
e?eoaaiiy.

A inoaii? aeanyoe??//y ?ic?iaeai? oa ii/aee canoiniaoaaoeny iaoiaee
aecia/aiiy o ne?iaaooe? e?ia? oae caai? iooeeii? ia?ea?e — aioeaaie, ye?
ae?iaeythoueny a iooeeiieo oeaieiao ? aei yeeo a?aeiinyoueny NA-125
(carbohydrate antigen 125), CA-19-9 (carbohydrate antigen 19-9), NAA
(carcinoembrionic antigen), MCA (mucine-like carcinoma antigen), OA
(oi??ii?/iee aiiaaeio?ii?i), AOI (aeueoaoaoii?ioa?i) oa ?io?. Ca aeaieie
A.N. Ii?ic, A.?. Ae?eaeae, ?.I. Aeeeai oa ?io., 1991, I.TH. Ea?iiaa,
I.I. Aa?aiiaa, ?.E. Ianiiiaa oa ?io., 1996, ai?no NA-125 cia/ii
ca?eueoaii o oai?eo ?aeii oeeee iaoee, y?/iee?a. O ca’yceo c oeei
W.R.Zurawski, 1988, ?aeiiaiaeo? aeei?enoaiiy aeaiiai iieiaioeaaia o
ne?ei?ia-ae?aaiinoeoe? oa ioe?ioe? aoaeoeaiino? i?neyiia?aoe?eiiai
e?eoaaiiy o oai?eo ?aeii y?/iee?a. Aeine?aeaeaiiy, i?enay/ai?
aeei?enoaiith ?ioeo ia?ea??a i?e ne?ei?iaiaeo aeine?aeaeaiiyo oa
ioe?ioe? ?o ae?aaiinoe/ii? aoaeoeaiino?, a e?oa?aoo?? ia i?aaenoaaeai?.

Iaeanueeee ?aa?ii ? aeieia?/iei aanaeiii ia iaae? ??cieo ee?iaoe/ieo cii
c? nai?ie iniaeeainoyie oi?ioaaiiy na?aaeiaeua i?iaeeaaiiy. Cia/ia
/anoeia ianaeaiiy ?aa?iio caeo/aia aei i?ioan?iiaeueii? ae?yeueiino?,
yea ii?aeio? a nia? oiiae i?iaeeaaiiy ia aa?ac? ? o?eaaeo ae?iaie/o
ae?yeuei?noue a oiiaao na?oiaiai ieaaio (I.I. Eiaaiei, 1993).

Aeeaie? aeine?aeaeaiiy, ye? aoee i?iaaaeai? a inoaii? aeanyoe??//y,
na?ae/aoue, ui o aeaii? eaoaai??? ae?iie aaeueie ?noioii ci?ith?oueny
oa?aeoa? ?ai?iaeoeoeaii? ooieoe??, a iniia? yei? eaaeeoue noaa?euei?noue
aaeaioaoe?eii-i?enoiniaaieo ?aaeoe?e ooieoe?iioaaiiy iae?i-aiaeie?eiii?
nenoaie (I.A. Caii?iae/aiei, I.A. Aiae???anueeee, 1996). A?aeiii, ui oey
nenoaia ia? i?yia a?aeiioaiiy o ?icaeoeo ai?iiiaeueiicaeaaeieo iooeei
ae?ii/i? noaoaai? noa?e. Ia aeoieo ie?aieo aeine?aeiee?a (I.I.
Cae?inueeee, 1992), ??aaiue aeayeeo iooeeiianioe?eiaaieo aioeaai?a iiaea
eieeaaoeny a caeaaeiino? a?ae aaee/eie eiioeaio?aoe?? noa?i?aeieo
ai?iii?a y?/iee?a. Oeae oaeo aeiaeaoeiai i?aeoaa?aeaeo? iaiao?aei?noue
i?iaaaeaiiy aeine?aeaeaiue ii iiioeyoe?ei?e “?aa?iiae?caoe??” ai?noo a
e?ia? iieiia?ea??a, ui iiaea iaoe aeoaea aaaeeeaa cia/aiiy ye o
i?aeaeuaii? iaae?eiino? aecia/aiiy ae?aaiinoe/ii? cia/ouino?
eiioeaio?aoe?? iieiaioeaai?a i?e aeyaeaii? ai?iiiaeueiicaeaaeieo iooeei,
oae ? o oe?eiio aeey ?aiiuei? ae?aaiinoeee ceiye?nieo ooai?aiue.

A ie?aieo iia?aeiieaiiyo (A.I. Aiae?a?aa, 1992) ? aeac?aee ia o? /e ?io?
iniaeeaino? ai?noo iieiaioeaai?a o ne?iaaooe? e?ia? i?e ae?oa?e
a?iaeieia?/i?e iaoieia??. Aiaeia?/ia a?aeiineoueny ? aei iaeii/aniiai
aeei?enoaiiy ?yaeo iieiia?ea??a o ae?aaiinoeoe? oa aeeoa?aioe?ei?e
ae?aaiinoeoe? a?ia?ieanoe/ieo, ia?aae?aeiaeo i?ioean?a ae?ii/eo noaoaaeo
i?aai?a ? aeia?iye?nii? iaoieia??, i?e i?iaaaeaii? ianiaeo ianoaaeaiue
ae?iie, a oiio /ene? aeeniaina?ieo.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoith aeine?aeaeaiiy aoei aecia/aiiy
oa oaeineiiaeaiiy ae?aaiinoe/ii? iiaeeeaino? aeei?enoaiiy iieieia?/ieo
ia?ea??a NAA, NA-125, NA-19-9, INA, OA, AOI o ne?iaaooe? e?ia?
ae?iie c? ceiye?nieie oa aeia?iye?nieie iooeeiaie ? iooeeiieie
caoai?thaaiiyie iaoee oa ?? i?eaeaoe?a i?e aeeniaina?ecaoe?? oa
ianoaaeaii? ae?iie, ye? i?aoeththoue ia aiaeiiio o?ainii?o?. Aeey
ae??oaiiy aeacaii? iaoe aoee aecia/ai? oae? caaaeaiiy:

1. Aecia/eoe no?oeoo?o a?iaeieia?/iiai caoai?thaaiiy o ae?iie, ye?
i?aoeththoue ia aiaeiiio o?ainii?o? oa ieoiio aaao aeia?iye?nieo ?
ceiye?nieo iiaiooai?aiue.

2. Aecia/eoe ?aa?iiaeuei? aeene?ei?iaoe?ei? (ii?iaia?) cia/aiiy ??aiy
iooeeiiianioe?eiaaieo aioeaai?a o ae?iie, aea/eoe aieea oac
iaino?oaeueiiai oeeeeo, ai?iiiaeueiiai noaoono i?aai?cio, a?eo ia
oi?ioaaiiy aeene?ei?iaoe?eieo cia/aiue iooeeiieo ia?ea??a o i?aeoe/ii
caei?iaeo in?a ? a a?oiao ?eceeo ?icaeoeo iieiiaoieia??.

3. ?ic?iaeoe noaio ianoaaeaiiy aeey aeyaeaiiy iieieia?/ieo caoai?thaaiue
o ae?iie, ye? i?aoeththoue ia aiaeiiio o?ainii?o?, ?c aeeth/aiiyi
aieaoii-iieooaaeueiiai iaoiaeo ? aecia/aiiy o e?ia? iooeeiianioe?eiaaieo
aioeaai?a.

4. I?iaanoe ioe?ieo iiaeeeainoae ?aiiuei? ae?aaiinoeee iooeeiieo
i?ioean?a i?e ianiaeo ae?aaiinoe/ieo ianoaaeaiiyo c canoinoaaiiyi
iieiaioeaai?a.

5. Aecia/eoe /ooeea?noue ? niaoeeo?/i?noue iaoiaeo aecia/aiiy ??aiy
NA-125, INA, NA-19-9, NAA o ne?iaaooe? e?ia? oai?eo aeia?iye?nieie oa
ceiye?nieie caoai?thaaiiyie y?/iee?a ? iaoee.

6. ?ic?iaeoe e?eoa??? ioe?iee aeei?enoaiiy iieiaioeaai?a NAA, OA,
NA-19-9, NA-125 aeey ae?aaiinoeee, aeeoa?aioe?eii? ae?aaiinoeee
aeia?iye?nieo oa ceiye?nieo iooeei aai?oae?e, ?aeiiaiaeaoe?? ii
aeei?enoaiith iaoiaeo ?ioiioa?iaioiiai aiae?co (?OA) a a?iaeieia?/i?e
i?aeoeoe?.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a.

· Aia?oa a iaaee/i?e i?aeoeoe? ia iniia? ii??aiyeueiiai aeine?aeaeaiiy
?acoeueoao?a ai?noo iieiaioeaai?a NAA, NA-19-9, NA-125, OA, INA aeyaeaia
iiaeeea?noue ?o aeei?enoaiiy i?e ianiaeo ianoaaeaiiyo i?aai?ciaaieo
eiioeiaaio?a ae?iie, ye? i?aoeththoue ia aiaeiiio o?ainii?o?.

· Aia?oa cai?iiiiiaai? ?aa?iiaeuei? aeene?ei?iaoe?ei? eiinoaioe
iieiaioeaai?a o i?aeoe/ii caei?iaeo ae?iie, iae?e cia/aiue yeeo
iioei?co? a??io ioe?ieo ?acoeueoao?a ianoaaeaiiy.

· Aia?oa aea/aii ai?no NAA, NA-19-9, NA-125, INA ii a?aeiioaiith aei
c??co iaino?oaeueiiai oeeeeo, ioe?iea yeiai ? aeioe?eueia ? iaiao?aeia a
?ioa?i?aoaoe?? aeaieo ?o ??aiy o ne?iaaooe? e?ia?.

· Anoaiiaeaii, ui aecia/aiiy NA-125, NAA, NA-19-9, INA ia ? niaoeeo?/iei
o aeeoa?aioe?ei?e ae?aaiinoeoe? aeia?iye?nieo iooeei ? iooeeiieo
caoai?thaaiue i?eaeaoe?a iaoee.

· Aecia/aia /ooeea?noue aecia/aiiy NA-125, NA-19-9, NAA, INA o ae?iie c
iayai?noth aeia?iye?nieo iooeei iaoee, y?/iee?a, aiaeiiao??icii,
caoai?thaaiiyie i?eaeaoe?a iaoee.

· Aecia/ai? ?yaee /ooeeaino? aeey iieiaioeaai?a o aeeoa?aioe?ei?e
ae?aaiinoeoe? aeia?iye?nieo-ceiye?nieo caoai?thaaiue ae?ii/eo noaoaaeo
i?aai?a.

· Anoaiiaeaii, ui aea/aiiy ai?noo ??ai?a NA-125, NA-19-9, NAA, INA a
aeeiai?oe? iiaea aooe e?eoa???i iieicaoai?thaaiiy.

· Anoaiiaeaii, ui ae?iee, ye? i?aoeththoue a oiiaao noaeii?aiiioo,
iathoue i?aeaeuaiee iieiaaiiee ?ecee ?icaeoeo iaiieaci y?/iee?a ? iaoee.
O ae?iie-?ia?oieoeue ieaaneeaaeo iieiaaiiee ?ecee ieae/a iiioeyoe?eiiai.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a.

· Aeyaeaii ? iaa?oioiaaii canoinoaaiiy aecia/aiiy ai?noo o ne?iaaooe?
e?ia? NA-19-9, INA, NAA, NA-125 ye ae?aaiinoe/ieo ?
aeeoa?aioe?aeueii-ae?aaiinoe/ieo e?eoa???a caoai?thaaiue aioo??oi?o
ae?ii/eo noaoaaeo i?aai?a, aeia?iye?nieo oa ceiye?nieo i?ioean?a
y?/iee?a ? iaoee.

· Aecia/ai? iiaeeeaino? oa i?noea iieiaioeaai?a o ne?ei?iaiaeo ? ianiaeo
ianoaaeaiiyo ae?iie, ye? i?aoeththoue ia aiaeiiio o?ainii?o?, ui
aeicaiey? ?o eiie?aoia aeioe?eueia aeei?enoaiiy o oe?ie?e a?iaeieia?/i?e
i?aeoeoe? iie?ee?i?e, ae?ii/eo eiinoeueoaoe?e, noaoe?iia??a.

· Cai?iiiiiaaia aeey i?aeoe/iiai aeei?enoaiiy iaoiaeeea iii?oi??iao
NA-19-9, NA-125, NAA, INA o e?ia? i?e niinoa?aaeaii? ca ae?ieaie c
iooeeiaie ? iooeeiieie caoai?thaaiiyie y?/iee?a, ye? iathoue ca
?acoeueoaoaie aecia/aiiy ai?noo aioeaai?a i?aeaeuaiee iieiaioeaaiiee
?ecee.

· Iaaeai? ?aeiiaiaeaoe?? ii aeei?enoaiith ?aa?iiaeueieo ii?iaiaeo
cia/aiue NA-125, NA-19-9, NAA, INA, OA ? ??aiy iieiaioeaai?a o ??ci?
oace iaino?oaeueiiai oeeeeo aeey ?iaeea?aeoaeueii? o?aeoiaee
?acoeueoao?a ianoaaeaiiy oai?eo.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaaaeaii
iaoaioii-?ioi?iaoe?eiee iiooe, aecia/ai? iaoiaee/i? i?aeoiaee, noai?ai?
aieaoi? ea?oe, i?iaaaeaii aiae?c ?acoeueoao?a aieaooaaiiy ae?iie,
aeanii?o/ii i?iaaaeaii aecia/aiiy ai?noo iieiaioeaai?a o an?o
ianoaaeaieo ae?iie, cae?eniaii aiae?c, nenoaiaoecaoe?y ? ia?iaea
?acoeueoao?a aeine?aeaeaiue. Ia iniia? io?eiaieo aeaieo ?ic?iaeai?
iniiai? iieiaeaiiy aeena?oaoe??. Iaa?oioiaaii iaoeia? aeniiaee ?
i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeine?aeaeaiiy. Iniiai? iieiaeaiiy
aeena?oaoe?eii? ?iaioe aeiiia?aeaeenue ia 1O c’?cae? ?anioae?eainueeiai
iaoeiaiai oiaa?enoaa e?ea??a — eaai?aio?a (i. Ai?ioeeiaa?aae, 1989), 1-e
Ananithci?e eiioa?aioe?? “Canoinoaaiiy ?OA-ae?aaiinoeee a i?aeoe/i?e
ioi?ii? caei?ia’y” (i. Ni/?, 1990), 1O c’?cae? aeooa??a-a?iaeieia?a ONN?
(i. Aei?i?iiao?ianuee, 1991), 2-e Ananithci?e eiioa?aioe?? “Canoinoaaiiy
?OA-ae?aaiinoeee a i?aeoe/i?e ioi?ii? caei?ia’y” (i. Naaanoiiieue,
1991), Ieaioi? i?aae?iiy iaoeiaiai oiaa?enoaa aeooa??a-a?iaeieia?a
Oe?a?ie “Aeieia?y ? ?ai?iaeoeoe?y” (i. Iaeana, 1992), 2-e
iaoeiai-i?aeoe/i?e eiioa?aioe?? e?ea??a-a?iaeieia?a aeeoy/iai oa
i?aee?oeiaiai a?eo Oe?a?ie (i. Iaeana, 1995), O c’?cae?
aeooa??a-a?iaeieia?a Oe?a?ie (i. Iaeana, 1996).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 16 iaoeiaeo ?ia?o : c
ieo 1 iiiia?ao?y, 4 noaoo? o oaoiaeo aeo?iaeao, 1 iaoiaee/ia
?aeiiaiaeaoe?y.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, iieno iaoiae?a aeine?aeaeaiiy, 3 ?icae?e?a aeanieo
aeine?aeaeaiue, iaaiai?aiiy e ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiue,
aeniiae?a oa nieneo aeei?enoaieo aeaea?ae. Iniiaiee oaeno ?iaioe
aeeeaaeaiee ia 107 noi??ieao iaoeiiieniiai oaenoo. ?iaioa
i?i?ethno?iaaia 32 oaaeeoeyie, 14 iaethieaie oa 1 noaiith. A?ae?ia?ao?y
neeaaea? 226 aeaea?ae, na?aae yeeo 80 — ?iicaiieo.

INIIAIEE CI?NO ?IAIOE

Iaoiaee ? iaoa??ae aeine?aeaeaiiy. Ca ia??iae c 1990 ii 1997 ?iee a
iie?ee?i?/ieo ? noaoe?iia?ieo oiiaao, a oaeiae i?e aeeniaina?ecaoe??
ae?iie, ye? i?aoeththoue ia aiaeiiio o?ainii?o? oa i?iaeeaathoue o
i?eaa?aaei?e cii?, ianoaaeaii 2152 iniae. Aeiaeaoeiai aeey aea/aiiy
?aa?iiaeueieo aeene?ei?iaoe?eieo eiinoaio iieiaioeaai?a ianoaaeaii 440
i?aeoe/ii caei?iaeo ae?iie-aeiii??a o 1-e oac? iaino?oaeueiiai oeeeeo (1
eiio?ieueia a?oia).

A ?acoeueoao? ianiaeo ianoaaeaiue ?c caeo/aiiyi oa?aiaao?a, o??o?a?a,
aiaeie?eiieia?a, ?ioaeoe?ii?no?a, aea?iaoi-aaia?ieia?a,
aeooa??a-a?iaeieia?a ? e?ea??a ?ioeo niaoe?aeueiinoae aeey iiaeeaeaiiai
ianoaaeaiiy o a?aeiia?aeiino? c oa?aeoa?ii aeine?aeaeaiiy c 2152 ae?iie
aoei a?ae?a?aii 505 iaoe?aioie ?ai?iaeoeoeaiiai a?eo. C ieo 44 ae?iee
neeaee ae?oao eiio?ieueio a?oio (AE2), ye? iaee ??ci? aiiiae?? ?icaeoeo
noaoaaeo i?aai?a, ooieoe?iiaeueii? oa iinoo?aaiaoe/ii? (i?neyiieiaiai?)
iani?iiiaeiino? i’yc?a oaciaiai aeia (AE2). Ia?oo eiio?ieueio a?oio
(AE1), ye aoei ?ai?oa aeacaii, neeaee 440 ae?iie-aeiii??a aac niiaoe/ii?
oa a?iaeieia?/ii? iaoieia??, ia?aaaaeii nooaeaioe AOC?a ? oaoi?eoi?a, a
oaeiae neoaeaiaoe? onoaiia iaae?iaie/iai oeio.

?io? 461 ae?iea aoee ?iciiae?eai? ia a?oie c o?aooaaiiyi ee?i?/iiai,
ii?oieia?/iiai, a?noieia?/iiai caeeth/aiiy.

Ia??iae ianoaaeaiiy neeaa 5 ?ie?a ? 8 i?nyoe?a ? aoa aecia/aiee
iaiao?aei?noth aeinoaoiino? ianyao aeine?aeaeaiue o eiaei?e c ee?i?/ieo
i?aea?oi ?c a?aeiia?aeieie iicieia?/ieie oi?iaie caoai?thaaiue.

Oaeei /eiii, a?oio ae?iie ?c caiaeueieie caoai?thaaiiyie iaoee,
i?eaeaoe?a (AC) neeaee 39 in?a, aeia?iye?nieie iooeeiaie ? iooeeiieie
ooai?aiiyie y?/iee?a (AAeIss) — 96, ciai?oi?i ? aioo??oi?i
aiaeiiao??icii — 184 iniae, c ieo c aaeaiii?icii (AAI) — 62,
aiaeiiao??icii y?/iee?a ? iaeeie oi?iaie aiaeiiao??ico oe?iei? ca’ycee
(AAss) — 122, ceiye?nieie ooai?aiiyie y?/iee?a (ACOss) — 15, ?aeii iaoee
(A?I) — 16, ?aeii oeeee iaoee (A?OI) — 9 ? i?iiith iaoee (AII) — 102.

O an?o oai?eo aeaoaeueii aea/aany i?aii?a?aeiee oii, ia?aianai?
niiaoiaaii? caoai?thaaiiy, niaaeeia?noue, noai noaoaai? ?ai?iaeoeoeaii?
ooieoe??, aaia?aoeaiee aiaiiac, a?iaeieia?/i? caoai?thaaiiy, oa?aeoa?
ia?aianaieo aioo??oiueiiaoeiaeo iai?ioeyoe?e, iia?aoe?e ? iia?aoeaieo
ao?o/aiue o oe?eiio. Iniaeeao oaaao i?eae?eyee c’ynoaaiith nea?a,
?icaeoeo caoai?thaaiiy, aeaeai ? caniaai e?eoaaeueieo ae?e ? a ia?oo
/a?ao ai?iiiaeueieo, ye? aenooiathoue iiia?aaeo ae?aaiinoeee, oa
aeyaeaiith iooeeiiiai i?ioeano.

C 505 ae?iie aeey i?iaaaeaiiy ii??aiyeueiiai aiae?co aoee noi?iiaai?
aeaa eiioeiaaioe ae?iie. Ia?oee eiioeiaaio (EA) neeaee 196 ae?iie, ye?
i?aoeththoue ia aiaeiiio o?ainii?o?, ae?oaee eiioeiaaio (EA) neaee 309
ae?iie, ye? iino?eii i?iaeeaathoue o i?eaa?aaei?e cii? oa ia iia’ycai? c
?iaioith ia noaeiao. C ia?oiai eiioeiaaioo (EA) a?oio caiaeueieo
caoai?thaaiue (ACA) neeaee 22 iniae, eiio?ieue AE2A — 24 iniae, AAeIssA
— 32, AAIA — 10, AAssA — 15, ACOssA — 5, A?OIA — 3, AIIA — 82.
A?aeiia?aeii na?aae ae?iie, ye? neeaee eiioeiaaio 2 (EA), ?iciiae?e ca
e?euee?noth niinoa?aaeaiue ii iicioi?iai neeaa : ACA — 17, eiio?ieue
(AE2A) — 20, AAeIssA — 64, AAIA — 52, AAssA — 107, ACOssA — 6, AIIA —
20. Aoaeue-yei? /?oei? caeiiii??iino? o ae?iie, ye? i?aoeththoue ia
noaeiao, ii niaeo?o caoai?thaaiue iaoee ? i?eaeaoe?a onoaiiaeoe ia
aaeaeinue, iaeiae, o in?a, ye? caeiathoueny noaeii?aiiioii, o oe?eiio
ieoiia aaaa iooeei y?/iee?a ? iaoee ia? oaiaeaioe?th aei c?inoaiiy.
Aiae?c noaio iaino?oaeueii? ooieoe?? na?ae/eoue i?i oa, ui ?? ii?ooaiiy
cia/ii ca?eueoothoueny o oai?eo c iooeeiaie ? iooeeiieie caoai?thaaiiyie
iaoee oa i?eaeaoe?a o ii??aiyii? c iiioeyoe?eiith. Ii??aiyii ?c
niinoa?aaeaieie EA, ye? i?iaeeaathoue ia aa?ac?, o ae?iie ieaaneeaaeo
o?ioe ca?eueoo?oueny ieoiia aaaa iiniiaii?ae, iaii?aa?e ? aeueaiiaii?ae.

Ia aeeeth/aii, ui ca?eueoaiiy ??aiy aiaeiiao??ico y?/iee?a o ae?iie, ye?
i?aoeththoue ia noaei? a?eueoa 5 ?ie?a, o ii??aiyii? c iiioeyoe?eiei
??aiai ia? aaciina?aaei? a?aeiioaiiy aei aeniei? ieoiii? aaae ii?ooaiue
iaino?oaeueii? ooieoe?? o aeaiiai eiioeiaaioo in?a ? ia? ca’ycie ?c
i?iyaaie aeacaaeaioaoe??, ?icaeoeo aeenai?iiiic?a ii a?aeiioaiith aei
iniaeeainoae ee?iaoiaaia?ao?/ieo cii na?oiaiai ieaaio oa ?o ci?i ca /an
aeiaaio?eaaeeo ?aeniaeo ia??iae?a.

O a?oi? oai?eo aeia?iye?nieie caoai?thaaiiyie iaoee ? i?eaeaoe?a in?a,
ye? aoiaeyoue aei EA, ca?eueoo?oueny e?euee?noue ieiia?eueieo aai?o?a
(?aii?o). Inoaoi?, ye a?aeiii, iiaeooue aooe iane?aeeii aiaeie?eiii?
aeen?aaoeyoe?? ooieoe?? y?/iee?a, a iaaeae? ca?eueoothoue ?ecee
ai?iiiaeueieo ii?ooaiue ? iiaeooue ni?eyoe iiyaeaiith ai?iiiaeueieo
iooeei. Oea ae a?aeiineoueny ? aei ieoiii? aaae ia?aae/anieo iieia?a,
ye? nooo?ai aeu? o ae?iie ieaaneeaaeo. E?euee?noue iia?aoe?e ooo/iiai
ia?a?eaaiiy aaa?oiino? a iaio eiioeiaaioao iaeiaeiaa.

A oe?eiio oa?aeoa?enoeea aaia?aoeaii? ooieoe?? iieaco?, ui ieoiia aaaa
iieia?a o a?oi? ae?iie ieaaneeaaeo o?ioe ieae/a ii??aiyii c oeie, ye?
i?aoeththoue ia aa?ac?. Iaaiith i??ith iiaeia iia’ycaoe
aeaci?aai?caoe?th, aeen?aaoeyoe?th iaino?oaeueii? ooieoe?? a in?a
ieaaneeaaeo c ii??aiyii aenieith ieoiiith aaaith aoi?eiii? aacie?aeiino?
o ieioeiio, ui aeiaaaei i?iaaaeaiiy eo?n?a ?aaa?e?oaoe?eii? oa?ai??.
Noeioeyoe?y ae iaa??aeueii? ooieoe??, yea i?iaiaeeoueny aaaaoi?aciai,
iaaiith i??ith ca?eueoo? ?ecee aeieeiaiiy iooeei ? iooeeiieo
caoai?thaaiue iaoee oa i?eaeaoe?a (ss.A. Aioiai, 1989).

O ae?iie ieaaneeaaeo aeineoue aenieee ??aaiue ia?aianaieo aai iayaieo
caiaeueieo caoai?thaaiue noaoaaeo i?aai?a. Iniaeeai ca?eueoo?oueny a?i o
a?oi? ae?iie c? ceiye?nieie caoai?thaaiiyie o?ea oa oeeee iaoee.

C o?aooaaiiyi aeio?eiaiiy i?aaeea ?ai?acaioaoeaiino? iaie niaoe?aeueii
ia aeeth/ai? a eiei ianoaaeaieo ae?iie eiioeiaaioo A (iniae c aaaeeei
i?io?eaiiyi aeno?aaai?oaeueieo caoai?thaaiue), ye? iiaee a aieeiooe ia
aeenia?ni?noue iieaciee?a iieiaioeaai?a. Inoaii?, oi/a ? ia ?
iaoiaiiiai?/ieie, i?ioa cia/ii /ano?oa cono??/athoueny o ae?iie, ye?
no?aaeaeathoue iooeeiaie ? iooeeiieie ooai?aiiyie aioo??oi?o ae?ii/eo
noaoaaeo i?aai?a.

I?aaenoaaey? oaeiae nooo?aee ?ioa?an o ae?iie eiioeiaaio?a A ? A
/ano?noue canoiniaaieo o ieioeiio ??cieo aeae?a e?eoaaeueieo aieea?a.
sseui ca aeaieie ianiaeo aeeniaina?ieo ianoaaeaiue 1647 ae?iie, e??i
a?ae?a?aieo aeey iiaeeaeaieo ianoaaeaiue 505 ae?iie, ( anueiai 2152)
ieoiia aaaa canoiniaaieo ?ai?oa ??cieo aeae?a oa?ai?? neeaaea? 68,2%, oi
o ae?iie c iooeeiaie ?

iooeeiieie ooai?aiiyie aai?oae?e aeinyaa? aeecueei 100%.

sse i?aaeei, an? caoai?thaaiiy o ae?iie a?oie EA aoee aeyaeai? i?ae /an
aeeniaina?iiai niinoa?aaeaiiy ? i?io?eaeoe/ieo iaeyae?a, ye? ?aaoey?ii
i?iaiaeyoueny a iie?ee?i?eao oeaio?aeueii? aanaeiiai? ee?i?/ii? e?ea?i?
ia aiaeiiio o?ainii?o? (OeAEEAO). Oaeei /eiii, o?eaae?noue caoai?thaaiiy
c iiiaioo ?iia??iiai eiai ee?i?/iiai ii/aoeo iiaea aooe a iaaeao iaeiiai
?ieo. A oie aea /an o ae?iie, ye? neeaaeathoue a?oio EA, oeyoii
aeaoaeueiiai aea/aiiy nea?a, aiaiiaco oa ?noi??? ?icaeoeo caoai?thaaiiy
iiaeii aoei a ia?aaeaa/eoe, ui o 32,8% aeia?iye?ni? oa ceiye?ni?
ooai?aiiy iaoee ? i?eaeaoe?a iiaee a aooe aeyaeai? cia/ii ?ai?oa (2 — 3
?iee) c ?ic?iaeith a?aeiia?aeiiai ieaio eiina?aaoeaiiai aai iia?aoeaiiai
e?eoaaiiy.

A oe?eiio ee?i?/ia oa?aeoa?enoeea ianoaaeoaaieo ae?iie eiioeiaaio?a A ?
A aea? iiaeeea?noue noaa?aeaeoaaoe, ui a a?oiao oai?eo c iooeeiaie oa
iooeeiieie ooai?aiiyie oeeee iaoee ? i?eaeaoe?a cia/ia ieoiia aaaa
ae?iie, ye? no?aaeaeathoue ii?ooaiiyie iaino?oaeueii? ooieoe??,
caiaeueieie caoai?thaaiiyie noaoaaeo i?aai?a, oneeaaeiaiei
?ai?iaeoeoeaiei aiaiiacii, ui ? eiiiiiaioii ?icaeoeo
ai?iiiaeueii-caeaaeieo iooeei aai?oae?e, ye? /anoi cono??/athoueny.
Iae?e oeeo aeaieo ii a?aeiioaiith aei aea/aiiy ??aiy iieiaioeaaiiino? a
ianiaeo aeine?aeaeaiiyo iiaeiai aooe iaia’yceiaei. O naith /a?ao oea
aeiaaa? cia/iiai ianyao aeine?aeaeaiue aeey /?oeiai aecia/aiiy ye
?aa?iiaeueieo aeene?ei?iaoe?eieo eiinoaio (AeE) iieiia?ea??a, na?aaei?o
?o cia/aiue i?e oeo aai ?ioeo iicioi?iao caoai?thaaiue, oae ?
niaoeeo?/iino? ? /ooeeaino?. Inoaii? iiaeooue iaoe i?yia a?aeiioaiiy aei
ai?iiiicaeaaeieo iooeei, yeeie ? caoai?thaaiiy aai?oae?e.

Ee?i?/ii-eaai?aoi?ia ianoaaeaiiy ae?iie aeeth/aei a iniiaiiio
o?aaeeoe?eiee caaaeueiee iaeyae c oa?aeoa?enoeeith oaiioeio, aoaeiae
o?ea, i?iyao a??nooecio, a?ia?o?eoico, noaio iiei/ieo caeic,
na?oeaai-noaeeiii?, aeeoaeueii?, na/iaeae?eueii?, ia?aiai?, o?aaii? ?
aiaeie?eiii? nenoai. I?iaiaeeany caaaeueii-ee?i?/iee aiae?c e?ia? oa
na/?, i?e iaiao?aeiino? aoiea?ae?ineii?y, ?aioaaiineii?y (oethi?ia?ao?y)
a?oaeii? ee?oee, eiaaoeia?aia, a?io?i?/i? aeine?aeaeaiiy e?ia?
(a?e??oa?i, caaaeuei?e a?eie, na/iaeia, aetheica, oieanoa?ei),
anoaiiaethaaeanue a?oia e?ia?, ?acon-oaeoi?, aaeoa??ineii?/ia,
aaeoa??ieia?/ia aeine?aeaeaiiy aeae?eaiue c i?oae. Ca iieacieeaie
i?iaiaeeeinue ?aioaaiieia?/ia ianoaaeaiiy oeoieiai-eeoeiaiai o?aeoo,
iaiia?ao?y, oeueo?aniiia?aia iiei/ieo caeic, oeueo?acaoeiaa
aeine?aeaeaiiy i?aai?a iaeiai oaco, ia/?iee, ie?ie, aeia/iiai i?oo?a,
ae?aaiinoe/ia aeoe??aaiiy neeciai? iaieiiee iaoee, eieueiineii?y,
iao?inaeuei?iaia?ao?y.

I?e iaiao?aeiino? o a?aeiia?aeiino? aei aeiia i?e ianoaaeaii? ae?iie c
eiie?aoieie iicioi?iaie caoai?thaaiue aeei?enoiaoaaee aoia?ao?th,
?iaeineii?/i? iaoiaee (eaia?i-, a?noa?ineii?y), iaiia?ao?th, aecia/aiiy
caaaeueiiai ? i?noeaaiai ?ioi?oaoo neeciaeo iaieiiie ieaei?o a?aeae?e?a
noaoaaeo oeyo?a. Oeueo?acaoeiaa aeine?aeaeaiiy (OCAe) i?aai?a iaeiai
oaco i?iaiaeeee c aeiiiiiaith na??e iiia?a/ii-iiacaeiaaeiueiai
neaioaaiiy aia?aoaie o??i “Aea?iuea — 2100”, “E?aioeaiaethoa?”, “Aeiea —
630”. A?noa?ineii?th ? eaia?ineii?th i?iaiaeeee ca aeiiiiiaith
a?noa?ineiia oa eaia?ineiia o??ie “Stortz”, ye i?aaeei i?ney
caaaeueiiee?i?/iiai ianoaaeaiiy i?e iaiao?aeiino? i?aeoaa?aeaeaiiy
ae?aaiico noaioeiciiai aa??aioa i?iie iaoee, aaeaiii?ica, neiae?iio
Aoa?iaia.

Aeey aecia/aiiy iieiia?ea??a NA-125, NA-19-9, INA, NAA, OA, AOI
aeei?enoiaoaaeenue iaai?e aeey ?ioiioa?iaioiiai aiae?co (?OA),
i?aaenoaaeai? NI “Ae?aiethn”. ?ioiioa?iaioi? oanoe aeuacaaaeaieo
iieiaioeaai?a ?ic?iaeai? oaaeoea?nueeith o??iith “Oioiaii Ey ?io” c
aenieith oi/i?noth ? a?aeoai?aiiyi ?acoeueoao?a.

Aecia/aiiy iaae ii?iaoeaieo iieaciee?a o eiio?ieueieo a?oiao iieacaei,
ui na?aaeiueinoaoenoe/i? iieacieee ??ai?a iieiia?ea??a o ae?iie-aeiii??a
a?eii a?ae 18 aei 45 ?ie?a neeaee o an?e a?oi? aeey NA-125-7,051,96
Iae/ie ; INA-3,41,7 Iae/ie; NA-19-9 – 18,83,0 Iae/ie, NAA 1,190,25
ia/ie.

Iaea?eueo? cia/aiiy eiioeaio?aoe?e aoee o a?oi? ae?iie a?eii a?ae 41 aei
45 ?ie?a, aea a??ia?aei?noue ??cieoe? ?acoeueoao?a i?ae ??cieie a?eiaeie
a?oiaie aoea a?aenooiy. A oiiaao i?iaaaeaiiy i?ioa?aeai?o oa
aeeniaina?ecaoe?? in?a, ui i?aoeththoue a oiiaao noaeii?aiiioo,
ieaaneeaaeo, na?aaeiueinoaoenoe/i? cia/aiiy eiioeaio?aoe??
iieiia?ea??a, ye? aea/athoueny i?e a?aenooiino? a?iaeieia?/ii?
iaoieia??, aeey NA-125 neeaee 9,81,23 Iae/ie, aeey INA – 5,61,3 Iae/ie,
aeey NAA 1,260,21 ia/ie, aeey NA-19-9 – 20,41,3 Iae/ie.

Aeai? ?acoeueoaoe o?ioe a?ae??ciythoueny a?ae oaeeo, ui iaaaaeai? a
e?oa?aoo??. sseui, ia aeoieo ?.I. Aiae?a?ai?, 1992, ? A. Folinvetall,
1989, aeey NAA a?i neeaaea? 1,3 ia/ie, aeey NA-19-9 — 18,2 — 18,3
Iae/ie (aaoi?e ?.I. Aiae?a?aa, 1992; P.E. Schwarts et al., 1987;
P.Fioretty et al., 1988) aeey NA-125 — 7,3 — 13,2 Iae/ie ( ?.I.
Aiae?a?aa, 1992;Y. Haga, K. Sakamoto, H. Egamy et al., 1986; P.E.
Pittaway, I.A. Fayez, 1986), aeey INA — 9,3 — 17,2 Iae/ie (A.A. Oea/iaa
oa ni?aaao., 1989), aeey AOI — 1 — 12 IIae/ie (A.A. Oea/iaa oa ni?aaao.,
1989), oi ca aeaieie iaoeo aeine?aeaeaiue niinoa??aa?oueny /?oea
oaiaeaioe?y aei ci?uaiiy iieaciee?a eiioeaio?aoe?e a a?e ?o a?eueo
aenieeo cia/aiue. I?e oeueiio aeey in?a, ye? i?iaeeaathoue a
i?eaa?aaei?e cii? ? i?aoeththoue a oiiaao noaeii?aiiioo, aiie iaea?eueo
aenie? (ui aeacaii a aeaaao 3, 4), a aeey ae?iie eaoaai??? ieaaneeaaeo
o?ioe ieae/?. Inoaii? iiaeia iiynieoe aeaoaeuei?noth i?iaaaeaiiy
i?ioan?eiiai a?aeai?o, ine?eueee a in?a, ui i?iaeeaathoue ia aa?ac? ?
caeiyo? o ??cieo neoaeaao *II, a ?ai?oa i?aoethaaee ia ai?oo noaeia,
aeai? iieacieee i?eaeecii aiaeia?/i? oaeei aeey in?a, ye? iino?eii
i?iaeeaathoue ia aa?ac? ? i?ioan?eii ia caeiyo? ?iaioith ia noaeiao.

I?e ia/eneaii? /ooeeaino? ie a?aooaaee /ano?noue, c yeith cia/aiiy
aeaiiai iieacieea ia ia?aaeuothoue aa?oith iaaeo aeia??/iai ?ioa?aaeo
(ii?iaa). Ca iane?aeeaie i?iaaaeaieo aeine?aeaeaiue, aa?oi?e ii??a
eiio?ieth (AIE) aeey NA-125 aeyaeany ??aiei 39,1 Iae/ie, ui o?ioe aeua
oiai, yeee iaaaaeaii a i?aoeyo T. Klug et al., 1984, K. C.Bast et al.,
1982. Aeey NAA AIE, ca aeaieie A. Folino, C. Diserio et al., 1989,
noaiiaea 2,5 ia/ie, a ca aeaieie i?iaaaeaieo iaie aeine?aeaeaiue – 2,4
ia/ie. Aeey NA-19-9 AIE, ca iaoeie aeaieie, noaiiaea 29,8 Iae/ie ?
aeyaeany o?ioe aeuei ii??aiyii c i?eeiyoei o a?eueoino? ?ia?o (
?.I. Aiae?a?aa, 1992).

Aeey INA, ca aeaieie e?oa?aoo?e, a?i noaiiaea 9,3 — 17,2 Iae/ie, a ca
iaoeie aeine?aeaeaiiyie — 10,7 Iae/ie. Oaea ??cieoey a aeaye?e i???
aieeioea ? ia aeniiaee, c?iaeai? ca ?acoeueoaoaie aeine?aeaeaiue.

Aea/aiiy eiioeaio?aoe?? NA-125 a e?ia? ?ai?oa i?iaiaeeeiny i?e ??cieo
ceiye?nieo iiaiooai?aiiyo oa i?e ie?aieo aeia?iye?nieo caoai?thaaiiyo
iaoee ? i?eaeaoe?a. Aaoi?aie a?aecia/aii, ui i?e caoai?thaaii? ia ?ae
aai?oae?e eiioeaio?aoe?y NA-125 a ne?iaaooe? e?ia? iiaea aeinyaoe iiiaae
1000 Iae/ie (I.A. Aeaen??aa ? ni?aaao., 1995).

Ca iaoeie aeaieie, iaea?eueo aenie? cia/aiiy NA-125 noaiiaeee 835 Iae/ie
( o oai?eo c iaoanoac??oaaiiyi ?aea y?/iee?a a eeoa/iee, naeueiee,
ia???oaeueio i/a?aaeio, o?aaao). A oe?eiio i?e ceiye?nieo iooeeiao
aai?oae?e /ooeea?noth aecia/aiiy NA-125 aoea iaeneiaeueiith, ui
a?aeiia?aea? a oe?eiio ?acoeueoaoai ?ioeo aeine?aeaeaiue. Iaie
anoaiiaeaii, ui iieiaaiiee o?eeooiee i?e iayaiino? ceiye?niiai ooai?aiiy
aai?oae?e yaii ie?aneaiee aaa?o. Oea aea? iiaeeea?noue aaaaeaoe
aecia/aiiy oeueiai ia?ea?a ye ne?ei?iaiaee oano ia ?ae y?/iee?a. sseui
ii??aithaaoe oa?aeoa?enoeee “iieiaaiiiai” o?eeooieea i?e aeai?e
iaoieia?? c ?ioeie iooeeiaie ae?ii/eo noaoaaeo i?aai?a, oi noa?
iiaeeeaei aeei?enoaiiy aecia/aiiy ??ai?a NA-125 aeey
aeeoa?aioe?eii? ae?aaiinoeee oeo aai ?ioeo a?iaeieia?/ieo caoai?thaaiue.

I?eeeaaeii oiio ? ii??aiyeueia oa?aeoa?enoeea o?eeooieea i?e i?ii?
iaoee, aeia?iye?nieo iooeeiao ? iooeeiieo ooai?aiiyo iaoee oa
i?eaeaoe?a, aiaeiiao??ic?, caiaeueieo i?ioeanao. ?acoeueoaoe
iieacothoue, ui i?e aeia?iye?ni?e iaoieia?? aenie? cia/aiiy NA-125 a
ne?iaaooe? e?ia? cono??/athoueny aeinoia??ii ??aeoa, i?ae i?e ceiye?nieo
iiaiooai?aiiyo. ??ai? eiioeaio?aoe?? NA-125, ca iaoeie aeaieie, o?ioe
aeu? aiaeia?/ieo, ui i?aaenoaaeai? a aeayeeo ?iaioao (?.I. Aiae?a?aa,
1992).

Oeae oaeo ua a?eueo ia?aeiio? ian a oiio, ui ?OA NA-125 iaiao?aeii
canoiniaoaaoe i?e aeeoa?aioe?ei?e ae?aaiinoeoe? aeia?iye?nii? ?
ceiye?nii? iaoieia?? aai?oae?e.

I?e aiaeiiao??ic? y?/iee?a aeyaeaii iaea?eueo aenie? eiioeaio?aoe??
aeaiiai ia?ea?a, ye? iiaeooue aeinyaoe 95 Iae/ie, ui cia/ii ieae/a, i?ae
i?e aiaeiiao??ic? iaoee, oi/a aeai? e?oa?aoo?e na?ae/aoue i?i cai?ioi?
(H.Kobayashi, 1987). ?c aeacaiiai /ooeea?noue NA-125 iaaeeaea?oueny aei
oaei? ae i?e ceiye?nieo ooai?aiiyo y?/iee?a ? aeiaaa? i?iaaaeaiiy
aeiaeaoeiaeo iaoiae?a aeine?aeaeaiiy. Iaie ia aeyaeaii nooo?aeo
??cieoeue na?aaei?o cia/aiue NA-125 i?e ?ao?ioea?a?eaeueiiio
aiaeiiao??ic? y?/iee?a, i?i ui i?aee?aneth? a nai?o aeine?aeaeaiiyo ?.I.
Aiae?a?aa, 1992.

A oe?eiio ai?no NA-125 i?e aioo??oiueiio aiaeiiao??ic? ca iaea?eueoith
u?euei?noth ?iciiae?eo iieaciee?a ia a?noia?ai? aei??aith? 15-38 Iae/ie,
a i?e ciai?oiueiio aiaeiiao??ic? — 20-140 Iae/ie i?e ie?aieo eieeaaiiyo
aeaiiai iieacieea aei 500 Iae/ie. Iaeneiaeuei? ae ?iaeea?aeoaeuei?
eiioeaio?aoe?? NA-125 i?e aiaeiiao??ic? neeaee 154,3 Iae/ie ? 138,8
Iae/ie — i?e ?ao?ioea?a?eaeueiiio aiaeiiao??ic?.

Oaeei /eiii, a?aeiia aecia/aiiy ??aiy NA-125 ca ?acoeueoaoaie oe???
?iaioe i?e aiaeiiao??ic? y?/iee?a – 31,43,9 Iae/ie, i?e
?ao?ioea?a?eaeueiiio aiaeiiao??ic? — 19,88,0 Iae/ie, i?e aaeaiii?ic? —
19,16,1 Iae/ie, a i?e aiaeiiao??ic? a oe?eiio — 23,24,0 Iae/ie. C
o?aooaaiiyi oiiaii iaaeniei? /ooeeaino? i?e aaeeeeo ?iaeea?aeoaeueieo
eiioeaio?aoe?yo aeaiiai iieacieea iaiao?aeii aaaaeaoe, ui aecia/aiiy
eeoa NA-125 iaaeinoaoiuei ?ioi?iaoeaii, ye iniiaa aeey ae?aaiinoe/iiai
aeniiaeo a oe?eiio aeey an??? a?oie ae?iie, ye? no?aaeaeathoue aeaiei
caoai?thaaiiyi. sseui i?iaanoe ii??aiyiiy i?ae na?aaei?ie
eiioeaio?aoe?yie NA-125 o oai?eo aiaeiiao??icii ? AIE, aai AeE , oi
iiaeia ia?aeiiaoeny, ui ae?aaiinoe/ia o?aeoiaea iaoieia?? iiaea aooe
i?eaeaoia eeoa a i?ioean? niinoa?aaeaiiy ? i?iaaaeaiiy eiiieaenii?
oa?ai??.

Aeey i?ii iaoee, aeia?iye?nieo iooeei y?/iee?a na?aaei? cia/aiiy
aeinoia??ii a?aei?ii? c aecia/aiith iaie aaee/eiith AeE, ui a oe?eiio
iiaea aooe aeinoaoiueith iniiaith aeey aeeoa?aioe?eiuei? ae?aaiinoeee. A
oeo aeiaaeeao eiioeaio?aoe?y NA-125 i?e na?icieo oeenoiaaeaiiiao
y?/iee?a ia?aaeuoaaee AeE ia 15 — 127% ? aeiaaaee ?io?aiia?aoe?eii?
a?noieia?/ii? ?ioa?i?aoaoe??. C o?aooaaiiyi iieiaaiiiai ?eceeo i?e
aeeniaina?ecaoe??, a oiio /ene? ae?iie ieaaneeaaeo, iaiao?aeii iai’yoaoe
i?i ?iaeea?aeoaeuei? eieeaaiiy eiioeaio?aoe?? NA-125 ? iaiao?aeiino?
i?iaeiaaeaiiy eiiieaeno aeiaeaoeiaeo aeine?aeaeaiue.

A ie?aieo aeine?aeaeaiiyo aeacaii (W. Neutenfel, G. Breitenmemecker,
1988) , ui i?e na?icieo e?noiiao y?/iee?a ??aaiue NA-125 o ne?iaaooe?
e?ia? ia ia?aaeuo? oaeee o i?aeoe/ii caei?iaeo ae?iie. Iao? aeai?
i?aeoaa?aeaeothoue oe? ?acoeueoaoe. I?ioa oaiaeaioe?y aei i?aeaeuaiiy
e?euee?nieo ia?aiao??a NA-125 ?, aeinoia??i? ae a?aei?iiino? a?aenooi?
/a?ac aenieo aeenia?ni?noue eiai cia/aiue.

O oie aea /an i?e e?noiiao aiaeiiao??iciiai iioiaeaeaiiy eiioeaio?aoe?y
NA-125 aeinoia??ii aeua “ii?ie” ? a 26,2 % aoaa? aeua AIE.
Aeei?enoiaoth/e ioe?ieo iieiaaiiiai o?eeooieea, iiaeia neacaoe, ui aeey
oai?eo c aiaeiiao??i?aeieie e?noaie oa?aeoa?ia “niaoeeo?/ia” eiai oi?ia,
oiaoi a?i aeoyaiooee a a?e NAA.

I?e ?ioeo aeia?iye?nieo ooai?aiiyo aai?oae?e ai?no NAA a ne?iaaooe?
e?ia?, e??i ?aeeiiai aeiaaeeo, ia aeoiaeeoue ca iaae? AeE ? oi?ia
o?eeooieea i?aeoe/ii aiaeia?/ia oaeiio ae, ye ? o ae?iie — aeiii??a oa
i?aeoe/ii caei?iaeo ae?iie i?e naeaeoeaieo aeeniaina?ieo ianoaaeaiiyo.
I?e oeueiio o?eeooiee “iieiaaiiino?” o?ioe iaioee ca nai?i ia’?iiei
?ici??ii, i?ae i?e eiai eiio?ao?aoe?? iaeneiaeueieo “ii?iaiaeo”
cia/aiue.

N?aaeiueiiiioeyoe?ei? eiioeaio?aoe?? NA-19-9 o ae?iie, ye? i?iaeeaathoue
o i?eaa?aaei?e cii?, in?a ieaaneeaaeo, a oiio /ene? ? ii AIE, i?aeoe/ii
?aeaioe/i?. Ni?anoaaeaiiy na?aaei?o eiioeaio?aoe?e NA-19-9 o e?ia?
ceiye?nieie ? aeia?iye?nieie iiaiooai?aiiyie aai?oae?e c AIE na?ae/aoue,
ui iieacieee ?o eiioeaio?aoe?e nooo?ai a?ae??ciythoueny. Ii??aiyiiy
aeaieo e?oa?aoo?e ? iaea?aeaieo iaie aeaieo na?ae/aoue, ui na?aaei?e
??aaiue NA-19-9 i?e iieiiaoieia?? aai?oae?e cia/ii aeuee AIE. sse
a?aecia/aeiny iaie ?ai?oa, ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue
iieacothoue, ui eiioeaio?aoe?y NA-19-9 o oaeeo oai?eo, ye? i?iaeeaathoue
a Iaeanueeiio ?aa?ii?, aeua, i?ae i?aaenoaaeaii a e?oa?aoo??
(a?aeiia?aeii 97,316,9 ? 69,410,2 Iae/ie). I?e oeueiio o 42% oai?eo aiia
aoea aeua ?aa?iiaeueiiai AeE.

I?e aeia?iye?nieo iooeeiieo ooai?aiiyo iaoee ? i?eaeaoe?a ca aeaieie
P. Fioretty, et al., 1988 i?aeaeuai? ?acoeueoaoe
NA-19-9 a e?ia? aeinoia??ii ??ci?, aea aeyaeythoueny aeinoia??ii ??aeoa
(eeoa o 14,9% oai?eo), i?ae i?e ?aeo y?/iee?a.

Ca iaoeie aeaieie, i?e aeia?iye?nieo iooeeiao ? iooeeiieo ooai?aiiyo
y?/iee?a /ano?noue ia?aaeuaiiy AIE (17,8%) ? na?aaeiueinoaoenoe/i?
cia/aiiy ??aiy NA-19-9 (18,42,5 Iae/ie) aeinoia??ii ieae/?, i?e
ceiye?nieo iiaiooai?aiiyo (415,08,4 Iae/ie a?aeiia?aeii). Ca?aeii c
aeaieie P. Fioretty et al., 1988, /ano?noue aenieeo cia/aiue NA-19-9 o
ne?iaaooe? e?ia? i?e aiaeiiao??ic? y?/iee?a aei??aith? 14,3%, oiae? ye
i?e na?icieo oe?noiaaeaiiiao — 7,7 %. Ca iaoeie aeaieie, ??aaiue NA-19-9
i?e aiaeiiao??ic? y?/iee?a ia?aaeuo? AIE o 51,4% aeiaaee?a, a o ae?iie c
aeia?iye?nieie iooeeiaie y?/iee?a — eeoa a 17,1 % aeiaaee?a. I?e i?iiao
iaoee ca aeaieie ?.I. Aiae?a?ai?, 1992, ??ai? NA-19-9, ye?
ia?aaeuothoue AIE, aeyaeaii eeoa o 2 c 78 oai?eo, a i?e caiaeueieo
caoai?thaaiiyo iaoee ? i?eaeaoe?a i? a iaeiiio c aeiaaee?a. Oaeei /eiii,
ca aeaieie aaoi?a, i?e aenieeo ??aiyo NA-19-9 c a?eueoei nooiaiai
aeinoia??iino? iiaeia aeeeth/aoe iayai?noue aeaieo aa??aio?a iaoieia??.

Aiae?coth/e ?acoeueoaoe ianiaeo ianoaaeaiue ? aea/aiiy eiioeaio?aoe??
NA-19-9 o 440 ae?iie-aeiii??a, iiaeia neacaoe, ui aeaiee aeniiaie iiaea
aooe i?eaeaoiei ? aeey ?ioa?i?aoaoe?? iieaciee?a NA-19-9 noiniaii aei
ianoaaeaiiai eiioeiaaioo ae?iie. Eeoa o 2 aeiaaeeao a in?a, ui
no?aaeaeaee caoai?thaaiiyie oeoieiai-eeoeiaiai o?aeoo, ? a iaei???
ae?iee c aoi?eiiith aacie?aei?noth aeyaeaii eiioeaio?aoe?? ia?ea?a o?ioe
aeua AIE.

Oaeei /eiii, iieacieee eiioeaio?aoe?? NA-19-9, NA-125 iiaeia
aeei?enoiaoaaoe i?e aeeoa?aioe?ei?e ae?aaiinoeoe? aeia?iye?nieo
aa??aio?a iaoieia?? a?ae ceiye?nieo iiaiooai?aiue.

Iniaeea?noue oi?ie “iieiaaiieo” o?eeooiee?a NA-19-9, NAA, NA-125 i?e ?o
iaeii/aniiio ni?anoaaeaii? iiaea i?aaenoaaeoe aeiaeaoeiao ?ioi?iaoe?th c
oi/ee ci?o iaae?eiino? aeniiaeo i?i iayai?noue ceiye?nieo iooeei
ae?ii/eo noaoaaeo i?aai?a, ine?eueee ?o eiioeaio?aoe?? i?aeaeuothoueny
iaeii/anii, aea i?e ??ci?e ?ioaineaiino? oaiio (%) i?e?inoo.

sseui ci?ie NA-125, NA-19-9 o na?aaeiueiio ia aeoiaeyoue ca iaae?
a?aeiia?aeiiai AIE, oi eiioeaio?aoe?y NAA ? ca?eueoaiith iaea?eueo
nooo?ai.

Ie, ye ? ?.I. Aiae?a?aa (1992), aiae?coth/e ?ioi?iaoeai?noue iieaciee?a,
aeei?enoiaoaaee ?ic?aooiie “oiiaiiai ianyao iieiaaiiino?”, yeee yaey?
niaith aeiaooie on?o o?ueio iieaciee?a, iiae?eaiee ia 100. Aeaiee
oiiaiee “ianya iieiaaiiino?” aeyaey?oueny i?e eiai a?ao?/iiio
cia?aaeaii? a aeaea?oia?e nenoai? eii?aeeiao ? yaey? niaith ?ioaa?aeueio
aaee/eio, yea oa?aeoa?ia aeey eiaeiiai c aa??aio?a iaoieia??.

Ia iniia? iaea?aeaieo ?acoeueoao?a iaiao?aeii c?iaeoe aeniiaie i?i oa,
ui NA-125 ? aea??iei ia?ea?ii iooeeiiiai o?aaeaiiy y?/iee?a. I?ioa eiai
niaoeeo?/i?noue aeey aeeoa?aioe?thaaiiy ceiye?nieo ? aeia?iye?nieo
iooeei aeaiiai i?aaio ia ia?aaeuo? 77,5%. Oaeei /eiii, oai?? c
aeia?iye?nieie caoai?thaaiiyie y?/iee?a i?e ??ai? NA-125, yeee ia?aaeuo?
AeE, aeiaaathoue i?iaeiaaeaiiy ianoaaeaiue ? niinoa?aaeaiiy a
aeeiai?oe?. Iaiao?aeii i?aee?aneeoe, ui nooi?iue i?aeaeuaiiy
eiioeaio?aoe?? NA-125 iaaaeaeaaoia ianyao ia?aeiii? iooeeie, aea aeia?a
a?aeaeaa? iayai?noue ie?aieo iaoanoac?a. Oiio ?acoeueoaoai aecia/aiiy
??aiy aeaiiai ia?ea?a iaiao?aeii i?eae?eyoe iniaeeao oaaao i?e
a?aenooiino? oeueo?acaoeiaeo i?aeoaa?aeaeaiue iayaiino? iooeeie,
ine?eueee NA-125 nooo?ai i?aeaeuo?oueny i?e aeoaea iaeaiuee?e ia?aeii?e
iooeei? c iayai?noth ae??aieo iaoanoac?a, ui ia aecia/athoueny ca
aeiiiiiaith i?iiaiaaeo iaoiae?a aeine?aeaeaiiy.

Aeey aeai?o ianooiii? oaeoeee ??aaiue NA-125 iiaeia aeei?enoaoe aeey
ae??oaiiy ieoaiiy i?i i?iaaaeaiiy ae?aaiinoe/ii? eaia?ioii??. Iaeii/ania
aeine?aeaeaiiy NA-125 c NAA, NA-19-9, AOI iieacaii ye aeiaeaoeiaee oano
a ae?aaiinoeoe? i?e?iaee iooeei i?e ie?aieo iaoanoacao aac aeyaeaiiy
ia?aeiiiai ina?aaeea, ine?eueee ?OA NA-125 ia aeaaaa o iaoeo
niinoa?aaeaiiyo inaaaeiiiceoeaieo ?acoeueoao?a i?e iooeeiieo
caoai?thaaiiyo eeoa/ieea. I?e iooeeiao y?/iee?a aia??iiaeueiiai oeio
aeioe?eueii aeei?enoiaoaaoe OA ( oi??ii?/iee aiiaaeio?ii?i ), oiaoi iiaa
eaea i?i iiaeeea?noue aeyaeaiiy eiie?aoiiai ii?oieia?/iiai oeio iooeeie.
Aeai? i?aeoaa?aeaeothoueny oei, ui i?e oa?aoiaeanoiiao iaeii/anii
ca?eueoo?oueny eiioeaio?aoe?y NA-125 ? AOI. O aeaio aeiaaeeao ie
iaea?aeaee ca?eueoaiiy ai?noo NA-125, ui ia?aaeuo? AeE o 5-6 ?ac?a i?e
aeainoi?iiiueiio oaeaiaoic? y?/iee?a o ae?iie c a?aenooi?noth
aiaoii?/iiai ca?eueoaiiy i?aaio.

A a?oiao eiio?ieth (aeiii?e, i?aeoe/ii caei?ia? iniae a ?acoeueoao?
naeaeoeaiiai ne?ei?iao) “iieiaaii?” o?eeooieee i?aeoe/ii ia
a?ae??ciythoueny. ?o ci?ia oi?ie iiaea niinoa??aaoeny i?e aeia?iye?nieo
caoai?thaaiiyo iaoee ? i?eaeaoe?a. Ii??aiyeueiee aiae?c oi?ie o?eeooieea
“iieiaaiiino?” a in?a ieaaneeaaeo, caeiyoeo o noaeii?aiiio?,
oa?aeoa?ecothoue oaiaeaioe?th aei aeayeiai ca?eueoaiiy eiai ianyao o
ae?oai? i?aea?oie (noaeii?aiiio) ? ciaioaiith a a?oi? ieaaneeaaeo
ii??aiyii c a?oiaie caei?iaeo ae?iie, ye? i?iaeeaathoue a i?eaa?aaei?e
cii?. I?ioa “iieiaaiiee” o?eeooiee o /anoeie ae?iie c i?aea?oie
ieaaneeaaeo c ii?ooaiiyi iaino?oaeueii? ooieoe?? i?ney o?eaaeeo ?aen?a
ia? ianya, aiaeia?/iee oaeiio i?e aeia?iye?nieo iooeeiao iaoee ?
i?eaeaoe?a. Oea aeicaiey? c?iaeoe aeniiaie, ui a in?a ieaaneeaaeo c?
noaaeai ?iaioe 5 ? a?eueoa ?ie?a i?aeaeuo?oueny ?ecee ?icaeoeo
aeia?iye?nieo iooeei iaoee ? i?eaeaoe?a, a oaeiae a?ia?ieac?e i?iiao??y
(i?iie). O ae?iie, ye? i?aoeththoue a oiiaao noaeii?aiiioo, o?eeooiee
“iieiaaiiino?”, ye ie oaea aeacoaaee, iaaaaeo? oaeee o in?a c iayaieie
iooeeiieie ooai?aiiyie iaoee ? i?eaeaoe?a, ui iiaeia ?icoe?ithaaoe ye
i?iya oaea ?nioth/iai aeenai?iiiica, ye oiio ?icaeoeo aeia?iye?nii? ?
ceiye?nii? iaoieia??. ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aeathoue
iiaeeea?noue, ii-ia?oa, aeiaeaoeiai aecia/eoe i?e aeeniaina?iiio
ianoaaeaii?, i?ioa?aeai?? a?oio ae?iie c oei aai ?ioei nooiaiai
iieiaaiiiai ?eceeo; ii-ae?oaa, cai?aeic?eoe ? i?aeoaa?aeeoe aiane?aeie
eiiieaeniiai aeiianoaaeaiiy ii/aoeia? oi?ie ?icaeoeo ceiye?nieo
ooai?aiue aai?oae?e; ii-o?ao?, aecia/eoe iiaeeeaee aeae ceiye?niiai
ooai?aiiy y?/iee?a ca aeaieie ci?uaiiy o?eeooieea “iieiaaiiino?” a oiio
/e ?ioiio iai?yieo (OA, AOI, NA-125, NA-19-9, INA, NAA) ?,
ii-/aoaa?oa, aeyaeoe ?iia??i?noue ?icaeoeo iooeei ?ioeo eieae?caoe?e.

AENIIAEE

1. O ae?iie, ye? i?aoeththoue ia aiaeiiio o?ainii?o?, a no?oeoo??
a?iaeieia?/ii? caoai?thaaiino? niinoa??aa?oueny i?aeaeuaiee ??aaiue
aeia?iye?nieo oa ceiye?nieo iooeeiieo caoai?thaaiue ae?ii/i? noaoaai?
noa?e.

2. O ae?iie, ye? i?iaeeaathoue a i?eaa?aaei?e cii?, ?aa?iiaeuei?
cia/aiiy ii?iaiaeo eiioeaio?aoe?e iieiaioeaai?a ia?aaeuothoue
caaaeueiii?eeiyo? ii?ie, ca aeiyoeii iieiia?ea?a NAA.
Na?aaeiueinoaoenoe/i? cia/aiiy NAA, NA-19-9, NA-125 nooo?ai aeu? o
ae?iie, ui i?aoeththoue a oiiaao noaeii?aiiioo ? ieae/? o ae?iie
ieaaneeaaeo ii??aiyii c oeie, ye? i?iaeeaathoue a i?eaa?aaei?e cii?.
Aeayea ca?eueoaiiy na?aaeiueinoaoenoe/ieo aaee/ei iieaciee?a
iieiia?ea??a o ia?o?e oac? iaino?oaeueiiai oeeeeo iaiao?aeii a?aoiaoaaoe
i?e ioe?ioe? iieaciee?a i?ae /an aeeniaina?iiai ianoaaeaiiy ae?iie, ye?
i?aoeththoue ia aiaeiiio o?ainii?o?.

3. I?e i?iaaaeaii? aeeniaina?ecaoe?? ae?iie, ye? i?aoeththoue ia
aiaeiiio o?ainii?o?, aecia/aiiy iieiaioeaai?a NAA, NA-19-9, NA-125, INA,
OA, AOI a ne?iaaooe? e?ia? iaiao?aeii i?iaiaeeoe i?e ae?aaiinoeoe?,
aeeoa?aioe?ei?e ae?aaiinoeoe? oai?eo c aeia?iye?nieie ? ceiye?nieie
iooeeiaie ? iooeeiieie ooai?aiiyie y?/iee?a oa iaoee.

4. Oi/i?noue ? aeinoia??i?noue ae?aaiinoeee a?iaeieia?/ii? iaoieia??
cia/ii i?aeaeuo?oueny i?e iaeii/aniiio aecia/aii? iieiia?ea??a NAA,
NA-19-9, NA-125, OA, INA ? aea? iiaeeea?noue i?iaanoe aeeoa?aioe?eio
ae?aaiinoeeo aeia?iye?nieo ? ceiye?nieo iooeei aioo??oi?o noaoaaeo
i?aai?a i?e ianiaeo ae?aaiinoe/ieo ianoaaeaiiyo.

5. Iaea?eueoo /ooeea?noue ? niaoeeo?/i?noue aeey ceiye?nieo iooeei
y?/ieea ia? iieiaioeaai NA-125, iaioo — NAA ? NA-19-9. Na?aaei? cia/aiiy
NA-125 i?e aeia?iye?nieo iooeeiao ? aiaeiiao??ic? oaeiae ia?aaeuo? oae?
o caei?iaeo ae?iie a?eueo ye o 2,5 ?ace.

6. I?e aiaeiiao??ic? aioo??oi?o noaoaaeo i?aai?a iaea?eueoo
ae?aaiinoe/io /eii?noue iathoue iieiaioeaaie NAA ? NA-19-9. I?e
caiaeueieo caoai?thaaiiyo iaoee ? i?eaeaoe?a, i?iiao iaoee,
aeia?iye?nieo iooeeiao ? iooeeiieo ooai?aiiyo y?/iee?a cia/aiiy NAA,
NA-19-9, NA-125, INA, OA ia aeoiaeeoue ca iaae? ii?iaiaeo cia/aiue o
i?aeoe/ii caei?iaeo ae?iie.

7. Iaea?eueoo ?ioi?iaoeai?noue i?e aeeniaina?iiio niinoa?aaeaii? ae?iie,
ye? i?aoeththoue ia aiaeiiio o?ainii?o?, c aeia?iye?nieie
caoai?thaaiiyie iaoee ? i?eaeaoe?a ? aenieei iieiaaiiei ?eceeii iathoue
iieiaioeaaie NAA, NA-125, NA-19-9 i?e oiia? aeeiai?/iiai aecia/aiiy ?o
ai?noo a ne?iaaooe? e?ia?. Ioe?iea ?yaeo iieaciee?a o /an? aea?
iiaeeea?noue nai?/anii ae??oeoe ieoaiiy i?i iaiao?aei?noue aeai?o ?
i?iaaaeaiiy iia?aoeaii? aai eiina?aaoeaii? oaeoeee e?eoaaiiy oai?eo.

Ia?ae?e i?aoeue, iioae?eiaaieo ca oaiith aeena?oaoe??

Iiiia?ao?y

. Caeeineee A.A., Noaioea A.A., Eiiiaaeaiei E.I. Iiooieaaua ia?ea?u a
aeeaaiinoeea caaieaaaiee i?aaiia ?ai?iaeoeoeaiie nenoaiu. — Iaeanna :
*a?iiii?uea, 1998. — 104 n.

Noaoo? a iaoeiaeo oaoiaeo aeaeaiiyo

2. Caeeineee A.A., Eiiiaaeaiei E.I. Eiioeaio?aoeey iieiia?ea?ia NA-125,
INA, NA-19-9, NAA, OA e AOI o aeeoaeueieoe i?ea?aaeiie ciiu e o aeaiuei,
caiyouo ?aaioie ia ii?neii o?ainii?oa // Aanoi. ii?neie iaaeeoeeiu. –
1998. — ? 2. — N.89-92 .

3. Eiiiaaeaiei E.I. Iieiaioeaaiu a aeeaaiinoeea caaieaaaiee
?ai?iaeoeoeaiie nenoaiu o aeaiuei // Aanoi. i?iae. aeie. e iaaeeoeeiu. –
1998. — ?14. — N.9-19.

4. Eiiiaaeaiei E.I. Ii?aaeaeaiea eioi?iaoeaiinoe cia/aiee o?iaiy NAA,
NA-19-9, NA-125 i?e aeeaaiinoeea caaieaaaiee aioo?aiieo aeaineeo iieiauo
i?aaiia // Aanoi. ii?neie iaaeeoeeiu. – 1998. — ?2. — N.92-94.

5. Eiiiaaeaiei E.I. Ii?aaeaeaiea noaiaie eioi?iaoeaiinoe
iiooieaannioeee?iaaiiuo aioeaaiia NAA, NA-19-9 e NA-125 a aeeaaiinoeea
caaieaaaiee aioo?aiieo aeaineeo iieiauo i?aaiia // Aanoi. i?iae. aeie. e
iaaeeoeeiu. – 1998. — ?15. — N.62-64.

Iaoa??aee iaoeiaeo eiioa?aioe?e oa c`?cae?a

6. Caeeineee A.A., AEeea E.Ae., Na?aaoeeee E.E., Eiiiaaeaiei A.E.,
Eiiiaaeaiei E.I. Iiuo i?aaiecaoeee ?aaeeieiioiiie eaai?aoi?ee e
iaania/aiea iaaeaaeiinoe aa ?aaiou // Iiaia a eaai?aoi?iie aeeaaiinoeea
aieaciae aioo?aiieo i?aaiia (a ?aiiai ainnoaiiaeoaeueiii ia?eiaea
aieacie): IV nuacae ?ani. iao/. iauanoaa a?a/ae – eaai?aioia: Oac.
aeiee. — Ai?ioeeiaia?aae, 1989. — N.354-355.

7. Caeeineee A.A., Eiiiaaeaiei A.E. Eiiiaaeaiei E.I. Iaoiaeu ioeaiee
yiaeie?eiiie ooieoeee ?ai?iaeoeoeaiie nenoaiu o aeaai/ae // Oace 2-i?
iaoeiai – i?aeoe/ii? eiioa?aioe?? e?ea??a — a?iaeieia?a aeeoy/iai oa
i?aee?oeiaiai a?eo Oe?a?ie. — Iaeana, 1995.- O.2. — N.28-30.

8. Eiiiaaeaiei E.I. Caeeineee A.A. Iiooieaannioeee?iaaiiua ia?ea?u a
aeeaaiinoeea ?aea ye/ieeia // O?oaeu 1O Nuacaea aeooa?ia — aeiaeieiaia
ONN?. – E., 1991. — N. 146-147.

9. Eiiiaaeaiei E.I. Cia/aiea ii?aaeaeaiey NA-125 aeey aeeaaiinoeee ?aea
ye/ieea i?e aeeniaina?ecaoeee // I?eiaiaiea EOA — aeeaaiinoeee a
i?aeoe/aneii cae?aaiio?aiaiee: Oac. aeiee. Ananithc. eiio. a.
Naaanoiiieue, 21-26 ieoya?y 1991.– I., 1991. — N.31.

10. Eiiiaaeaiei E.I. Iniaaiiinoe i?eiaiaiey NA-125 aeey ?aiiae
aeeaaiinoeee ?aea ye/ieeia a a?oiiao aunieiai iieieiae/aneiai ?enea //
I?eiaiaiea EOA — aeeaaiinoeee a i?aeoe/aneii cae?aaiio?aiaiee: Oac.
aeiee. Ananithc. eiio. a. Ni/e, 16 ieoya?y 1990.- I., 1990. – *.1.- N.
38-39.

11. Eiiiaaeaiei E.I., Noaioea A.A., Eiiiaaeaiei A.E., Eaaaiaeianueeee
TH.A. Iooeei? ia?ea?e a ae?aaiinoeoe? ?aeo iiei/ii? caeice // O?oaee
O-ai c’?caeo aeooa??a — a?iaeieia?a Oe?a?ie. – Iaeana, 1996.- Ei. 2. —
N.46.

12. Eiiiaaeaiei E.I., Noaioea A.A., Oo?aiei A. Eniieueciaaiea
iieiia?ea?ia aeey iiieoi?eiaa iiooieaauo i?ioeannia a aeaoneie
iieieiae/aneie i?aeoeea // Oace 2-i? iaoeiai – i?aeoe/ii? eiioa?aioe??
e?ea??a — a?iaeieia?a aeeoy/iai oa i?aee?oeiaiai a?eo Oe?a?ie. — Iaeana,
1995. – O. 2. — N.47-49.

13. Eaaaaeaiei A.N., Ai?ae??a A.N. Eiiiaaeaiei E.I. Oa?ai?y iicaiaoeiai?
aaa?oiino? iaoao?aenaoii — aeueoa?iaoeaiee aa??aio iia?aoeaiiio
e?eoaaith // O?oaee O- c’?caeo aeooa??a — a?iaeieia?a Oe?a?ie. —
Iaeana, 1996.- Ei. 2. — N.47.

14. Eeiieeia A.E., Einaaa A.A., Eiiiaaeaiei A.E., Eiiiaaeaiei E.I.,
A?aaaiee A.Ae. Enneaaeiaaiea eiioeaio?aoeee noa?ieaeiuo e iaioeaeiuo
ai?iiiia a e?iae aeaai/ae a i?aioaa?oaoiii ia?eiaea n ioyaiuaiiui
eaoaiiacii // Oace 2-i? iaoeiai — i?aeoe/ii? eiioa?aioe?? e?ea??a —
a?iaeieia?a aeeoy/iai oa i?aee?oeiaiai a?eo Oe?a?ie.- Iaeana, 1995. –
O.1. — N.35.

15. Iicaiaie TH.N. Eiiiaaeaiei E.I. Noaioea A.A. Yeieiai —
yieaeaieieiae/aneea aniaeou oa?icu i?a?uaaiey aa?aiaiiinoe e
i?aaeaeaa?aiaiiuo ?iaeia a Iaeanneie iaeanoe (ii ?acoeueoaoai
ecae?aoaeueiiai naeaeoeaiiai ne?eieiaa) // Yeieiaey e ?ai?iaeoeoeey:
Oac. aeiee. — Iaeanna, 1992. — N.82.

16. Oea/aaa A.A., Eaaeaaeaeca C.A., Oai/aiei I.Ae., *aaioa?aaa Y.Ae.,
Nieieia A.A., Aeaenaaaa I.E., Iieiaeue A.A., AEi?aeaiey E.E., Oaeeo
A.I., Euoea?ue A.I., Eiiiaaeaiei E.I. Eiioiioa?iaioiua oanou ia
iiooieaannioeee?iaaiiua aioeaaiu (NA-125, AFP, HCG) i?e iiaiia?aciaaieyo
aeaineeo e ioaeneeo ?ai?iaeoeoeaiuo i?aaiia: Iaoiae. ?ae. / Ananithc.
iieieia. iao/. oeaio? AII NNN?. — I., 1989.-35 n.

AIIOAOe?ss

Eiiiaaeaiei E.I. Canoinoaaiiy ?ioiiiao?e/ieo iaoiae?a aeey aeyaeaiiy
iooeei ?ai?iaeoeoeaii? nenoaie o ae?iie, ye? i?aoeththoue ia aiaeiiio
o?ainii?o?. — ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.34 — aa?aoe?eia,
eini?/ia oa ii?nueea iaaeeoeeia — AeI “Oe?a?inueeee IAe? ii?nueei?
iaaeeoeeie”, Iaeana, 1998.

Caoeua?oueny iaoeiaa ?iaioa oa 16 iaoeiaeo aeine?aeaeaiue.

A ?acoeueoao? ianoaaeaiiy 2152 ae?iie, ye? i?aoeththoue ia aiaeiiio
o?ainii?o?, ? 404 i?aeoe/ii caei?iaeo ae?iie (aeiii??a) ?c canoinoaaiiyi
ee?i?/ieo, ?ino?oiaioaeueieo, a?io?i?/ieo, aiaeie?eiieia?/ieo,
a?noieia?/ieo iaoiae?a aeine?aeaeaiiy ia?aae aecia/aiiyi a ne?iaaooe?
e?ia? iieiaioeaai?a NA-125, NA-19-9, NAA, OA, INA anoaiiaeai?
?aa?iiaeuei? aeene?ei?iaoe?ei? eiinoaioe iieiia?ea??a, ?o
na?aaeiueinoaoenoe/i? iieacieee i?e aeia?iye?nieo oa ceiye?nieo
caoai?thaaiiyo iaoee oa aeiaeaoe?a, /ooeea?noue, niaoeeo?/i?noue oa
?ioi?iaoeai?noue. Io?eiai? aeai? aeicaieythoue i?iaiaeeoe ae?aaiinoeeo,
aeeoa?aioe?aeueio ae?aaiinoeeo a?iaeieia?/ii? iaoieia?? i?e ianiaeo
aeeniaina?ieo ianoaaeaiiyo oeueiai eiioeiaaioo ae?iie.

Eeth/ia? neiaa: iieiia?ea?e, iooeeie, ae?aaiinoeea, ?ioiiiao?e/i?
iaoiaee, ?ai?iaeoeoeaiay nenoaia, ae?iee, aiaeiee o?ainii?o.

AIIIOAOeEss

Eiiiaaeaiei E.I. I?eiaiaiea eiioiiiao?e/aneeo iaoiaeia aeey auyaeaiey
iiooieae ?ai?iaeoeoeaiie nenoaiu o aeaiuei, ?aaioathueo ia aiaeiii
o?ainii?oa. — ?oeiienue. Aeenna?oaoeey ia nieneaiea noaiaie eaiaeeaeaoa
iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.34 — aaeaoeeiiiay,
einie/aneay e ii?neay iaaeeoeeia. – AI “Oe?aeineee IEE ii?neie
iaaeaoeeiu”, Iaeanna, 1998.

Caueuaaony iao/iay ?aaioa e 16 iao/iuo ioaeeeaoeee.

A ?acoeueoaoa ianeaaeiaaiey 2152 aeaiuei, ?aaioathueo ia aiaeiii
o?ainii?oa e 404 i?aeoe/anee caei?iauo aeaiuei (aeiii?ia) n
eniieueciaaieai eeeie/aneeo, eino?oiaioaeueiuo, aeioeie/aneeo,
yiaeie?eiieiae/aneeo, aenoieiae/aneeo iaoiaeia enneaaeiaaiey ia?aae
ii?aaeaeaieai a nuai?ioea e?iae iieiaioeaaiia NA-125, NA-19-9, NAA, OA,
INA ii?aaeaeaiu ?aaeiiaeueiua aeene?eieiaoeeiiiua eiinoaiou
iieiia?ea?ia, n?aaeianoaoenoe/aneea iieacaoaee i?e aeia?iea/anoaaiiuo e
ceiea/anoaaiiuo caaieaaaieyo iaoee e i?eaeaoeia, /oanoaeoaeueiinoue,
niaoeeoe/iinoue e eioi?iaoeaiinoue. Iieo/aiiua aeaiiua iicaieytho
i?iaiaeeoue aeeaaiinoeeo, aeeooa?aioeeaeueioth aeeaaiinoeeo
aeiaeieiae/aneie iaoieiaee i?e ianniauo aeeniaina?iuo ianeaaeiaaieyo
yoiai eiioeiaaioa aeaiuei.

Eeth/aaua neiaa: iieiia?ea?u, iiooiee, aeeaaiinoeea, eiioiiiao?e/aneea
iaoiaeu, ?ai?iaeoeoeaiay nenoaia, aeaiueiu, aiaeiue o?ainii?o.

ANNOTATION

Konovalenko L.N. The application of immunometric methods for diagnosing
the tumors of the reproductive system of women who are engaged at the
sea transport. — Manuscript. Thesis for a scientific degree of a
candidate of medicine on a specialty 14.01.34 — air, space and sea
medicine. – State Company “Ukrainian Scientific and Discovery Institute
of the Sea Medicine”, Odessa, 1998.

The scientific work and 16 scientific publications are defended.

The results of research of 2152 women who work in sea transport and who
are practically healthy (as they are donors) using clinical,
instrumental, biochemical, endocrinal methods before calculation in
blood serum tumor antigens CA-125, CA-19-9, CEA, HCG,MCA it was found
out regional and discriminative constant tumor markers and their medium
statistic index in benign and malignant tumors of uterus and ovaries,
the sensitivity, specificity and information.

These results allow to make perform differential diagnosis of
gynecological pathology in mass dispanserization of named groups of
women.

Key words: tumor markers, tumors, diagnostic, immunometric methods,
reproductive system, women, sea transport.

Caeaii a iaai? 6.10.98 ?. Oi?iao 60o84/16 ia’?i
1,0 ae.e. Ionaoiee ae?oe

Iiaei. aei ae?oeo 9.10.98 ?. Caiiaeaiiy 390
Oe?aae 100 i?ei.

Ae?iaie/i-iieia?aoi/iee aiaeaeie IOeIOAI

Oe?a?ia, 270026, i.Iaeana, aoe. ?ioaeue?anueea, 28

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