?INOEOOO AA?IIOIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

NAI*?E Aaneeue Ieeieaeiae/

OAeE 577.122.5:616.24-36-001

AIEEA IIIIENEAeO AOAEAOeTH OA A?IA?OA?I?? IA NEIOAC AEEICAII?Ae?A OA
AI?III?A, UI ?AAOETHTHOUe CAAEAAEUe EE?OEI A EAAAIAA?E OEAIEI?

03.00.04 — a?io?i?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoeiai-aeine?aeieoeueeiio oeaio?? Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe Eiia?aaoeaaa ??eia
Ieaenaiae??aia i?ioani?, caa?aeoaa/ea eaoaae?e iaaee/ii? o?i??
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe Aa?o?aonueeee Ianoi?
Na?a?eiae/ i?ioani?, caa?aeoaa/ eaai?aoi??? aiaeie?eiieia?? ?inoeoooo
aa?iioieia?? AII Oe?a?ie i.Ee?a

aeieoi? a?ieia?/ieo iaoe Inoai/aiei Ethaeieea ?aai?aia, aieiaiee
iaoeiaee ni?a?ia?oiee eaoaae?e a?io?i?? Iaoe?iiaeueiiai oi?aa?neoaoo
?iai? Oa?ana Oaa/aiea, i.Ee?a

I?ia?aeia onoaiiaa: ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei
?i.A.I.Eii?na?aiea AII Oe?a?ie, i.Ee?a, eaai?auei??y iae?io?i??

Caoeno a?aeaoany 23 aa?aniy 1999 ?ieo i 14-30 ia

can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.551.01 a ?inoeooo?
aa?iioieia?? AII Oe?a?ie (252114, i.Ee?a, aoe.Aeoai?iaenueea, 67).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo

Aaoi?aoa?ao ?ic?neaiee «4»na?iiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee ?.?.Iioaiaiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aei oeueiai /ano aoea i?iaaaeaia aaeeea e?euee?noue
aeine?aeaeaiue, i?aaeiaoii yeeo aoei aea/aiiy nenoai, ui aa?ooue o/anoue
a ?aaoeyoe?? ee?oeiii? caaeaae?, a oaeiae oiia, ye? aaaeooue aei ??
?icaeoeo (Virchow R. 1977; Lockshin R.A. 1997). Ee?oeiia nia?oue ia
?icaeyaea?oueny a?eueoa ye eaoano?io?/ia ?oeioaaiiy ee?oeiii?
oe?e?niino? — a ye e?ioeaaa oi/ea oe?eiai ?yaeo eaneaae?a iaoaaie?/ieo
i?ioean?a, ui i?io?eathoue ye ana?aaeei? ee?oeie, oae ? a i?aai?ci? a
oe?eiio. Iaeia c nenoai, yea aa?a o/anoue a ?aaoeyoe?? ee?oeiii?
caaeaae?, ? nenoaia aeeicaii?ae?a (Vane J.R 1971, Aiiaceia I.A. 1987).
Oe?eaa? ee?i?/i? oa aenia?eiaioaeuei? niinoa?aaeaiiy, ye? iia’ycai? c
?i?oe?aoe??th aaiieo iaoai?ci?a aiiioico oa ?icaeoeii ee?oeiii? nia?o? a
??cieo oeaieiao i?ney aieeao iiiieneaeo aoaeaoeth, aeeeeeathoue
iaiao?aei?noue o a?eueo oe?ieiio ?icaeyae? ?ie? oe??? iiaeae? a i?ioean?
ee?oeiii? nia?o? (Piantaqdosi C.A. 1997, Uoeianueeee A.A. oa ?i. 1996).
Iniaeeaee ?ioa?an nueiaiaei? i?eaa?oa? ieoaiiy, i?enay/aia aecia/aiith
?ie? ? i?noey iiiieneaeo aoaeaoeth (NI) oa nenoaie aeeicaii?ae?a a
i?ioean? ?aaoeyoe?? ee?oeiii? caaeaae? a eaaaiaa?e oeaiei?, ui
aena?oeaia iaaeinoaoiuei. Ieoaiiy i?i aieea a?iien?? ? a?ia?oa?i?? oa ?o
noi?nii? ae?? ye /eiiee?a, ui aeeeeeathoue ee?oeiio nia?oue, ia ??aaiue
neioaco aeeicaii?ae?a, noai iae?iaoii?aeueii? nenoaie oa ia ee?oeiio
oe?e?ni?noue, caeeoa?oueny iaei aea/aiei, iacaaaeath/e ia oa, ui oe?e
i?iaeai? oaeiae i?eae?ey?oueny oaaaa (Naa/aieiaa E.A. 1995; Wyllie
A.H.1993; Aaaoenyi A.I. ?c ni?aaao. 1987).

O i?aaenoaaeai?e ?iaio? i?iaaaeaii aea/aiiy a?ineioaco aeeicaii?ae?a a
oiiaao ia?aa??aaiiy, ae?? iiiieneaeo aoaeaoeth, a oaeiae ca oiiae ?o
noi?niiai aieeao, ui aeicaieeei aeyaeoe iaa?aeii? aein? aca?iia?aeiineie
i?ae ??aiyie neioaco i?inoaaeaiaeei?a ??cieo a?oi, oeeee?/ieo
ioeeaioeae?a oa nooiaiai ee?oeiii? caaeaae? a eaaaiaa?e oeaiei? uo??a.
Ie??i oeueiai aeaia aeine?aeaeaiiy aeaei a?aeiia?aeue ia ieoaiiy, yeei
/eiii aiaeie?eiia nenoaia ?aaao? ia oiiae, ui i?ecaiaeyoue aei ?icaeoeo
ee?oeiii? caaeaae?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iiaeaia ?iaioa
aeeiiaia a iaaeao eiieo?nii? aea?aeathaeaeaoii? oaie IIC Oe?a?ie oa
ieaiiai? aea?aeathaeaeaoii? oaiaoeee Eoaainueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo — «Aieea aeieia?/ii iaaacia/ieo oaeoi??a ia
i?aai?ci a oiiaao i?iieneiaiai ?aa?iio oa ?ic?iaea iaoiae?a ei?aeoe??
iaoaaie?cio e ?ioaineaii? oa?ai??» ? aea?aeaaii? ?a?no?aoe??
01.9.10.033409.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoith ?iaioe aoei aecia/aiiy ai?noo
i?inoaaeaiaeei?a, oeeee?/ieo ioeeaioeae?a oa ai?iii?a, ui aa?ooue
o/anoue a ?aaoeyoe?? ee?oeiii? caaeaae? a eaaaiaa?e oeaiei?, yea aeieea?
i?ae aieeaii a?ia?oa?i??, iiiieneaeo aoaeaoeth, oa ?o noi?ni?e ae??.

Aeey ?aae?caoe?? iaoe aoei ae??oaii oae? caaaeaiiy:

?ic?iaeaii aenia?eiaioaeueio iiaeaeue, ui aeeeeea? caaeaaeue ee?oei
a?iioiaeueaaiey?iiai aea?aaa in vivo a oiiaao aieeao a?ia?oa?i??,
iiiieneaeo aoaeaoeth oa ?o noi?nii? ae??.

Anoaiiaeaii iniaeeaino? a?ineioaco i?inoaaeaiaeei?a A2 ? F2a ?c
aiaeiaaiieo iiia?aaeiee?a oa oeeee?/ieo ioeeaioeae?a a oeaieiao ie?ie
(ei?? ? iaaeoe?) a oiiaao a?ia?oa?i??, a oaeiae eiioeaio?aoe?th oeeo
niieoe a eaaaiaa?e oeaiei? (a i?aa?e ? e?a?e eaaai?) o oaa?ei i?e
a?ia?oa?i??, a?iien?? oa ?o noi?niiio aieea?.

Aeine?aeaeaii nooi?iue ?oeioaaiiy ai?oae?th a?iioiaeueaaiey?iiai
aea?aaa, oeyoii aecia/aiiy ?iaeaeno aeaaaia?aoe?? a?thaaoiai ai?oae?th
(?AeAA) a aenia?eiaioaeueieo oiiaao ? aeyaeaii noai ee?oeiieo
oeueo?ano?oeoo? a oeaieiao eaaaiue, ie?ie ? ia/?iee uo??a e?i?? Wistar a
oiiaao a?ia?oa?i??, aeey i?aeoaa?aeaeaiiy ?icaeoeo ee?oeiii? caaeaae?.

Aecia/aii noai aioo??ee?oeiieo oa?iaioaoeaieo nenoai aeueaaiey?ieo
iae?ioaa?a eaaaiue uo??a i?e a?ia?oa?i??, a?iien?? ? ?o ni?eueiiio
aieea? ye iaei??? ?c oa?aeoa?enoee ee?oeiii? caaeaae?.

Aecia/aii ai?no aae?aiiei?oeeio?iiiiai ai?iiio (AEOA), iao-aieaoae?io,
ia?aoe?ai?aeiiai ai?iiio (IOA), eaeueoeeoii?io, aeueaeinoa?iio,
aeoeaiino? ?ai?io ieacie (A?I) o ?ioaeoieo oaa?ei oa oaa?ei i?ae aieeaii
a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?niiio aieea?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa ?ic?iaeaii
aenia?eiaioaeueio iiaeaeue noeioeueiaaii? ee?oeiii? caaeaae?, eio?a
?icaeaaeany a eaaaiaa?e oeaiei? i?ae aieeaii a?ia?oa?i??, iiiieneaeo
aoaeaoeth oa ?o noi?ni?e ae??. Aia?oa cae?eniaii eiiieaenia
aeine?aeaeaiiy ? i?iaaaeaii ii??aiyeueiee aiae?c ae?? a?ia?oa?i??,
iiiieneaeo aoaeaoeth oa ?o ni?eueiiai aieeao (ye /eiiee?a, ui
aeeeeeathoue ee?oeiio nia?oue) ia ciiaeueio ie?eiao (ei?eiao oa
iaaeoey?io) ? eaaaiaao (i?aaa ? e?aa eaaaiy) eiioeaio?aoe?th
i?inoaii?ae?a (i?inoaaeaiaeeie A2 ? F2a) oa oeeee?/ieo ioeeaioeae?a
(oe-AIO ? oe-AIO). Aia?oa iieacaia ??cieoey i?ae oeaieiieie
eiioeaio?aoe?yie i?inoaaeaiaeei?a oa oeeee?/ieo ioeeaioeae?a o i?aa?e oa
e?a?e eaaai? i?ae aieeaii i?aeaeuaii? oaiia?aoo?e, iiiieneaeo aoaeaoeth
oa ?o aca?iiae??. Aia?oa iieacaii aieea aeine?aeaeoaaieo oaeoi??a ia
aeaye? eaiee aiaeie?eiii? nenoaie, ye? a?aeiia?aeathoue ca aaeaioaoe?th
aei oiia oaiia?aoo?iiai oa a?iiene/iiai no?ano, oa ca’ycie oeeo
i?ioean?a ?c ai?noii ?ii?a Na+ ? Ca2+ a ie?eia?e oeaiei? ? ieaci? e?ia?
a aenia?eiaioaeueieo oaa?ei. Aecia/ai? eiioeaio?aoe?? iao-aieaoae?io,
AEOA, IOA, eaeueoeeoii?io, aeueaeinoa?iio, A?I, ui aeicaieeei
cai?iiiioaaoe noaio aaeaioaoe?eii-eiiiainaoi?ieo iaoai?ci?a, ui
aeieeathoue i?ae /an ?icaeoeo ee?oeiii? caaeaae? a oiiaao ?ic?iaeaii?
iaie aenia?eiaioaeueii? iiaeae?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeyaeai? ci?ie ?AeAA,
ii?ooaiiy a?ineioaco i?inoaaeaiaeei?a oa ai?noo oeeee?/ieo ioeeaioeae?a
a eaaaiaa?e ? ie?eia?e oeaieiao, a oiiaao ae?? a?ia?oa?i?? oa iiiieneaeo
aoaeaoeth, iiaeooue neoaeeoe aeiiii?aeieie iieacieeaie aeey aecia/aiiy
nooiaiy ?icaeoeo a ieo ee?oeiii? caaeaae?.

Aeyaeai? ci?ie a aeeoo?aiio oeeee? ee?oei (aeeooy ee?oeie — caaeaaeue
ee?oeie) a oiiaao aieeao a?ia?oa?i??, a?iien?? oa ?o ii?aeiaiiy aeathoue
i?aenoaao i?eionoeoe, ui i?e ?icaeoeo a?ia?i?ie?oa?aoeaieo i?ioean?a, a
iniia? yeeo eaaeeoue i?eai?/aiiy i?ioean?a i?ia?aiiaaii? ee?oeiii?
caaeaae?, iiaeeeaa ? aeioe?eueia canoinoaaiiy oieaeueii? a?ia?oa?i??, ye
/eiieea, ui noeioeth? ee?oeiio caaeaaeue.

?acoeueoaoe aeine?aeaeaiiy aca?iica’yceo neioaco i?inoaii?ae?a,
oeeee?/ieo ioeeaioeae?a oa ai?iii?a c ?aaoeyoe??th aeaeo?ie?oiiai
aaeaino a ii?i? ? a aenia?eiaioaeueieo oiiaao, aeeth/ai? a o/aiao
i?ia?aio eaoaae?e iaaee/ii? o?i?? Eoaainueeiai Aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo c oai: “Aiaeii-nieueiaee iai?i ? eiai ?aaoeyoe?y” ?
“Ai?iiie, ai?iiiiiiae?ai? ?a/iaeie oa ?o iina?aaeieee”.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a i?e aeeiiaii? aeena?oaoe?eii?
?iaioe iieyaa? ianaiia?aae o naiino?eiiio aeeiiaii? iaeyaeo e?oa?aoo?e,
o/ano? o aeeiiaii? aenia?eiaioo, noaoenoe/i?e ia?iaoe? io?eiaieo
aiae?c?a oa ?ioa?i?aoaoe?? io?eiaieo aeaieo, a oaeiae o oi?ioethaaii?
aeniiae?a ?iaioe. Noaoo?, ui iioae?eiaai? a ni?aaaoi?noa? a «Oe?aeineii
aeioeie/aneii aeo?iaea» ? a «I?iaeaiao aeieia?/ii? oa iaaee/ii? aaiaoeee
? ee?i?/ii? ?ioiieia??», i?noyoue iaea?aeai? caeiaoaa/ai ?acoeueoaoe, a
yeeo a?aeia?aaeai? iaoiaeeee aenia?eiaioaeueiiai aeine?aeaeaiiy c
aecia/aiiy ai?noo i?inoaaeaiaeei?a, ii?oieia?/i? aeine?aeaeaiiy.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ?acoeueoao?a
aeena?oaoe?? aeiiia?aeaeeny ia XV c’?cae? Oe?a?inueeiai o?c?ieia?/iiai
oiaa?enoaa (i. Aeiiaoeuee 1998 ?.); ia IV i?aeia?iaeiiio eiia?an?
iieiaeeo a/aieo ? nooaeaio?a — iaaeee?a (Iieueua 1998 ?.); ia
i?aeeaoaae?aeueiiio can?aeaii? i?aoe?aiee?a eaoaae?e iaaee/ii? o?i?? ?
iaoeiai-aeine?aeiiai oeaio?o Eoaainueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

Ioae?eaoe??. Ca ?acoeueoaoaie aeaii? ?iaioe iioae?eiaaii 6 iaoeiaeo
noaoae a o?ueio oaoiaeo aeaeaiiyo, c ieo aea? a ?aeeiiio aaoi?noa?, oa 2
aeiiia?ae? — a iaoa??aeao aeaio iaoeiaeo eiioa?aioe?e oa c’?cae?a.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 159
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, iieno iaoa??ae?a oa iaoiae?a aeine?aeaeaiiy, 3 ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/iiai iaaiai?aiiy iaea?aeaieo ?acoeueoao?a
oa aeniiae?a. Nienie aeei?enoaii? a?o/eciyii? oa ?iicaiii? e?oa?aoo?e
aeeth/a? 32 a?o/eciyieo oa 323 ca?oa?aeieo aeaea?aea. ?iaioa
?ethno?iaaia 12-ia oaaeeoeyie, 6-ia ae?aa?aiaie, 3-ia ?enoieaie, 4-ia
i?e?ioioia?ao?yie.

INIIAIEE CI?NO ?IAIOE

Ia’?eoe oa iaoiaee aeine?aeaeaiiy. Aeine?aee iinoaaeai? ia 220
uo?ao-naioeyo 3 i?ny/iiai a?eo ianith 200-250 a?. Oaa?eie aoee iiae?eai?
ia 3 aenia?eiaioaeuei? a?oie oa iaeio a?oio eiio?ieth. Aeey i?iaaaeaiiy
aenia?eiaioo aoei canoiniaaii oa?iioieneeieia?/io eaia?o (Iiaea?a A.I.
1988 (AN 1452526)). O ia?o?e aenia?eiaioaeuei?e a?oi? oaa?ei i?aeaeaaaee
ae?? a?ia?oa?i?? (+43 — +45°C) i?ioyaii 1 aiae., a ae?oa?e — ae??
iiiieneaeo aoaeaoeth (NI) a eiioeaio?aoe?? 2000-2500 ia/i3 i?ioyaii 10
oa., a o?ao?e — ni?eueiiio aieeao a?ia?oa?i?? oa NI. O eiaei?e a?oi?
aecia/aeeny ??ai? aiaeiaaiiiai a?ineioaco i?inoaaeaiaeei?a (IA) A2, F2a
oa oeeee?/ieo ioeeaioeae?a a aiiiaaiaoao eaaaiaai? oeaieie (i?aai? oa
e?ai? eaaai? ie?aii) (Oliw 1980). Aoee aecia/ai? eiioeaio?aoe?? AEOA,
iao-aieaoae?io, IOA, eaeueoeeoii?io, aeueaeinoa?iio a ne?iaaooe? oa
aeoeai?noue ?ai?io ieacie (A?I). Aoa ae?aooaaiee ?iaeaen aeaaaia?aoe??
a?thaaoiai ai?oae?th (?AeAA), iinoaaeai? ?aaeoe?? aeey aeyaeaiiy noaio
aeoeaiino? aeueaaiey?ieo iae?ioaa?a (AI) (INO-oano, oaaioeeoa?ia /enei,
oaaioeeoa?iee ?iaeaen, e?euee?noue aeeaeo AI).

E?euee?nia aecia/aiiy an?o iaoaaie?o?a i?iaiaeeeiny iaoiaeii
?aae?i?ioiiiai aiae?co i?ney ?o iiia?aaeiuei? aeno?aeoe?? oa
eiioeaio?aoe??. Aeine?aeaeaiiy aeeiiai? ca aeiiiiiaith noaiaea?oieo
eiia?oe?eieo iaai??a o iiai?e a?aeiia?aeiino? c aeiaeaieie aei ieo
?ino?oeoe?yie. Aoee aeei?enoai? iaai?e oaeeo o??i: AEOA, IOA, A?I o??ie
«CIS Biointernational» (O?aioe?y), aeueaeinoa?iio — o??ie «Sorin
Biomedica» (?oae?y), eaeueoeeoii?io — o??ie «Byk-Sangtec Diagnostica»
(O?aioeey), iao-aieaoae?io — o??ie «Instar Corporation» (NOA), IAF2a —
o??ie «Institute of isotopes» (Oai?ueia), IAA2 — o??ie «Advanced
Magnetics Inc.» (Aaeeeia?eoai?y), oeAIO ? oeAIO — o??ie «Chemapol»
(*aoineiaae?y). I?ae?aooiie ?aae?iaeoeaiino? i?iaiaeeee ia e?/eeueieeao
«Aaoa-1» e «Aaiia-1». O ia?o?e aenia?eiaioaeuei?e oa eiio?ieueieo a?oiao
o oaa?ei aeiaeaoeiai aecia/aee ??aaiue ?ii?a Na2+ oa Na+ a ei?eiaiio oa
iiceiaiio oa?? ie?ie ? a ieaci? e?ia?. Oaeiae aoei aeeiiaii
aeaeo?iiii-i?e?ineii?/ia aeine?aeaeaiiy oeaieie ie?ie, eaaaiue oa
ia/?iee aeey aecia/aiiy iciae, oa?aeoa?ieo aeey ?icaeoeo ee?oeiii?
caaeaae?. E?euee?nia aecia/aiiy a?eea i?iaiaeeee ca iaoiaeii Lowry
(1951). Aei??thaaiiy aeaeo?ie?o?a a oeaiei? oa ne?iaaooe? e?ia?
i?iaiaeeeenue ca aeiiiiiaith aoiiii-aaeni?aoe?eiiai niaeo?ioioiiao?o
N-115-I1.

Ia?aeiiee oeeo?iaee iaoa??ae aenia?eiaioaeueieo aeine?aeaeaiue aoa
ia?iaeaiee o?aaeeoe?eieie iaoiaeaie aa??aoe?eii? noaoenoeee. Aeey
ioe?iee a??ia?aeiino? io?eiaieo ?acoeueoao?a aoa aeei?enoaiee e?eoa??e
Nouethaeaioa. ?acoeueoaoe ?icoe?ithaaeenue ye noaoenoe/ii aeinoia??i?
i?e p<0,05. ?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. I?ae /an ae?? aeno?aiaeueieo oaeoi??a a ee?oei? aeieea? aaiiiia oa aiiainoacia ianoaa?euei?noue, yea i?ecaiaeeoue aei aeieeiaiiy aaeaioaoe?eii-eiiiainaoi?ieo i?ioean?a a ee?oei? aai aei aeaeiiiainaoe??, i?iyaii yei? ? ?icaeoie ee?oeiii? caaeaae? (Eoiao 1995, Nieiaueyi 1990). Aoei ?ic?iaeaii aenia?eiaioaeueio iiaeaeue ee?oeiii? caaeaae?, i?ae /an ?icaeoeo yei? a i?e a?aeaoaathoueny ci?ie a aoaeia? oa no?oeoo?? aioo??oiueiee?oeiieo i?aaiae. Aeey i?aeoaa?aeaeaiiy ?icaeoeo caaeaae? ee?oei aoei canoiniaaii aeaeo?iiio i?e?ineii?th. Aeaeo?iiii-i?e?ineii?/ia aeine?aeaeaiiy eaaaiue iieacaei, ui aeueaaieioeeoe ca?eueoai? a ?ici???, ea??ieaia caa?aaeaia, iaeiae i?ino?? i?ae aioo??oiueith ? ciai?oiueith iaia?aiith ?icoe?aiee. Niinoa??aa?oueny aaeeea e?euee?noue thieo i?oioiiae??e, aiie ie?oaei? oi?ie, aeaui ca?eueoai? a ?ici???, aea i?aeoe/ii aac iao?eeno. Noa?? i?oioiiae??? oa?aeoa?ecothoueny ii?ooaiiyi aoaeiae e?eno, aae aei ?o iiaiiai cieeiaiiy, iao?een na?oeee, niinoa??aa?oueny a?oiueeoaaiiy iieiaeeo i?oioiiae??e. Aeaaeeee oa oi?noeee aiaeiieaciaoe/iee ?aoeeoeoi ?icoe?ai?. Ia iai?aoiieiio c??c? a?iio?iee aeaeii, ui ee?oeie neeciai? iaieiiee oa i?aeee?oeiia iaia?aia iaa?yee? ? iiaaii aecia/athoueny. Oeeoiieacia iaa?yeea, aea caa??aa? naith no?oeoo?o. ssae?a e?ioioeeo?a, eio?? aoee o iie? ci?o, caa??aaee naith aoaeiao, i?ioa yaea?iee o?iiaoei eiiaeainiaaiee ii ia?eoa??? yae?a. ? yae?a c ii/aoeiaeie iciaeaie naaiaioaoe??. A oeeoiieaci? niinoa??aa?oueny aaeeea e?euee?noue aaeoieae c a?eueo iioe/ii u?eueiei ai?noii. I?oioiiae??? ca?eueoai?. Aeey i?aeoaa?aeaeaiiy ?icaeoeo aaia?ae?caoe?? i?ioeano ee?oeiii? caaeaae? aoee i?iaaaeai? aeaeo?iiii-i?e?ineii?/i? aeine?aeaeaiiy ie?ie oa ia/?iee. Anoaiiaeaii, ui i?ae aieeaii a?ia?oa?i?? a?eueo?noue ee?oei ei?eiaiai oa?o ie?ie aoea aac aeano?oeoe?? oeeoiieaciaoe/ieo i?aaiae. O ?yae? ee?oeiieo yaea? aoa aeyaeaiee i?eiic o?iiaoeio, a oaeiae iaa?ye ea??ieaie. I?oioiiae??? - c? noa?oei iaethieii e?eno. Ai?no aaeoieae ? e?cinii ciaioaiee. O i?ieneiaeueieo a?aeae?eao ie?eiaeo eaiaeueoe?a iao?iio aoei aeyaeaii ?oeioaaiiy ie?aieo ee?oei. Ee?oeie, ui ioi/othoue c?oeiiaai?, caeeoathoueny a?coaeueii oe?eeie, oi/a a ?o yae?ao o?iiaoei ciaoiaeeoueny a eiiaeainiaaiiio noai?. Aeaiee i?ioean a?coaeueii iaaaaeo? ii?aeiaiiy aeaio aeae?a ee?oeiii? nia?o? - iae?ico oa aiiioico. Inoaii?e a?ae??ciy?oueny a?ae i?iya?a iae?ico oei, ui i?e iania?e caaeaae? ee?oei a?aeaoaa?oueny ?oeioaaiiy yaea? oa i?aaiae ee?oei, i?e oeueiio a iaaeieiee?oeiiee i?ino?? aeeeaea?oueny aaeeea e?euee?noue e?ciniiaeueieo oa?iaio?a, oeeoie?i?a, aiane?aeie /iai iaaeieeoi? ee?oeie aeiooue. Aeine?aeaeaiiy aaiaoioeeo?a uo??a iieacaee, ui ieaciieaia ee?oei ci?iaia. ssae?a iathoue iaaeueio oi?io c ??aieie e?ayie. O?iiaoei ciaoiaeeany ia?aaaaeii a aeeoociiio noai?, aea niinoa??aaeeny yae?a c e?aeiaith eiiaeainaoe??th yaea?iiai o?iiaoeio, oeaio?aeueiei o?aaiaioa?iei eiai ?ic??aeaeaiiyi ? ea??ii?eiicii. I?oioiiae??? caa??aaee nai? ?ici??e ? oi?io, i?ioa iaethiie e?eno aoa iii??ii noa?oee. A?aei?/aeiny a?aea?oiueeiaoaaiiy iieiaeeo i?oioiiae??e, aea aac ?o iiaeaeueoiai a?aeoio?iaoaaiiy. Oeeoiieacia caa??aaea naith no?oeoo?o, o?ioe ca?eueoeeeny e?euee?noue ? ia'?i aaeoieae. Aiaeiieaciaoe/iee ?aoeeoeoi, ye aeaaeeee, oae ? oi?noeee, aoa aeia?a ae?aaeaiee, aea aeaui ?icoe?aiee. Ii?oieia?/i? ci?ie a ai?oae?? a?iio?aeueiiai aea?aaa, ye? aeieeaee i?ney aieeao a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?nii? ae??, aoei i?iaiae?ciaaii ca aeiiiiiaith aecia/aiiy ?AeAA o?aoa?, i?aaiai oa e?aiai aieiaiiai a?iio?a uo??a. Oae, i?e a?ia?oa?i?? a oeeoieia?/iiio aeine?aeaeaii? iace?a-a?aeaeoe?a a i?aia?aoao ca?eueooaaeany e?euee?noue neeco. C?inoaei /enei iaeo?io?e?a. Ee?oeii? aeaiaioe ?icoaoiaoaaeeny a?oiaie o aeaeyae? neoi/aiue ? ia?aaoaaee a ii/aoeia?e noaae?? aeaaaia?aoe??. ?AeAA aeinoia??ii c??n a o?aoa? a 1,6, i?aaiio a?iioo a 1,8, a a e?aiio - a 1,2 ?ace. O a?oi? oaa?ei, o yeeo iiaeaethaaany aieea ia i?aaie aeeoaiiy iiiieneaeo aoaeaoeth, i?e oeeoieia?/iiio aeine?aeaeaii? a?iio?aeueiiai ai?noo a iaceao-a?aeaeoeao aeyaeyeany a iaaaeee?e e?eueeino? neec, iaeici?iai? eaeeioeeoe, AI ? ee?oeie oeee?iae?e/iiai ai?oae?th. Ieneae aoaeaoeth aeinoia??ii i?aeaeuoaaa ?AeAA a o?aoa? a 1,4 ?ace a i?aaiio a?iioo a — 1,2 ?ace. C?inoaiiy ?AeAA a e?aiio a?iioo i?aeoe/ii ia a?aeaoaaeiny. I?e noi?niiio aieea? a?iien?? ? a?ia?oa?i?? oeeoieia?/ia aeine?aeaeaiiy aeyaeei aaeeeo e?euee?noue neeco. Ee?oeii? aeaiaioe, a iniiaiiio eaeeioeeoe, AI, e?ioioeeoe ? ee?oeie a?iio?aeueiiai ai?oae?th, ?icoaoiaoaaeeny aaeeeeie a?oiaie o aeaeyae? neoi/aiue ? iaoa?oaaiue, ui oo?oaeithaaei ?o o?aineieaoe?th oa eiiia?aoe?th. Aeaaaia?aoeai? ci?ie ee?oeiiiai neeaaeo aoee a?eueo ae?aaeaieie. Cieaeoaaeany ooieoe?iiaeueia caeaoi?noue a?thaaoiai ai?oae?th. Ae??oaii aoei ii??aiyoe nooi?iue aieeao oaeoi??a aenia?eiaioo ia caeaoi?noue aei aeaeeaaiiy, ye AI, oae ? a?thaaoiai ai?oae?th o?aoaia?iio?aeueiiai aea?aaa, c iaoith ii??aiyiiy aenia?eiaioaeueieo oiia, ye? aeeeeeathoue iaeneiaeueiee ??aaiue ee?oeiii? caaeaae?. O ca'yceo c oeei iaie aoa aaaaeaiee eiao?oe??io ee?oeiii? caaeaae?, a eio?iio a?aoiaoaaeanue e?euee?noue aeeaeo ee?oei na?aae caaaeueiiai /enea ee?oei (N=100) ? yeee aecia/aee ca oi?ioeith: EEC = 100 - caaaeueia e?euee?noue ee?oei, ui i?ae?aoiaoaaeanue Ne - e?euee?noue aeeaeo ee?oei i?ney aieeao iioeiaeaeoth/iai oaeoi?a Ne - e?euee?noue aeeaeo ee?oei a eiio?ieuei?e a?oi?. - a?aei?iaiiy aecia/a? e?euee?noue ia?oaeo ee?oei a caaaeuei?e a?oi? ee?oei Aeaiee eiao?oe??io iieaco? a ne?eueee ?ac?a e?euee?noue caaeaeeo ee?oei i?ney ae?? iioeiaeaeoth/iai oaeoi?a ia?aaaaea? iaae e?euee?noth caaeaeeo ee?oei a eiio?ieuei?e a?oi? (?en.1). Aeey ioe?iee aca?iica'yceo ?icaeoeo ee?oeiii? caaeaae? c ooieoe?iiaeueiei noaiii ee?oei aoei i?iaaaeaii aeine?aeaeaiiy ooieoe?iiaeueii? aeoeaiino? AI, oiio ui aiia ciaoiaeeoueny a i?yi?e caeaaeiino? a?ae oe?e?niino? aioo??ee?oeiieo no?oeoo? ? ee?oeie a oe?eiio. Aeine?aeaeaiiy ooieoe?iiaeueiiai noaio AI aeiiiiiaei ioe?ieoe nooi?iue ooeiaeaeaiue ee?oei, a caeaaeiino? a?ae aeaeo iiae?acieea, eio?ee aeeeeeaa ?icaeoie ee?oeiii? caaeaae?. I?ney aieeao a?ia?oa?i??, ooieoe?iiaeueiee noai AI cia/ii ci?ieany. Oaaioeeoa?ia /enei iiiaioaei a 1,63 ?ace, oaaioeeoa?iee ?iaeaen ciaioeany a 3,93 ?ace, INO-oano ae??n a 3,14 ?ace, oao?acie??aa aeoeai?noue ae?inea a 1,59 ?ace, a e?euee?noue aeeoo?caeaoieo AI cieceeany a 1,58 ?ace. NI aieeioa iaio ae?aaeaii, i?ae ia?aa??aaiiy ia noai AI. ?en. 1. Eiao?oe??ioe ee?oeiii? caaeaae? aeueaaiey?ieo iae?ioaa?a oa a?thaaoiai ai?oae?th o?aoaia?iio?aeueiiai aea?aaa i?e ae?? a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?niiio aieea? I?ae aieeaii a?iien?? ooieoe?iiaeueiee noai AI ci?ieany oaeei /eiii: oaaioeeoa?ia /enei cieceeiny a 1,23 ?ace, oaaioeeoa?iee ?iaeaen AI iiiaioaa a 1,63 ?ace, INO-oano ae??n a 1,84 ?ace, oao?acie??aa aeoeai?noue ca?eueoeeany a 1,86 ?ace, e?euee?noue aeeoo?caeaoieo AI i?aeoe/ii ia a?ae??ciyeanue a?ae a?oie eiio?ieth. Ia iniaeeao oaaao caneoaiaothoue ?acoeueoaoe aeine?aeaeaiue i?noeaaeo caoenieo iaoai?ci?a i?aai?a aeeoaiiy i?e noi?niiio aieea? ia ieo iiiiieeno aoaeaoeth ? aeniei? oaiia?aoo?e iaaeieeoiueiai na?aaeiaeua. Noai ooieoe?iiaeueii? aeoeaiino? AI o oaa?ei oe??? a?oie oa?aeoa?ecoaaany cia/iei cieaeaiiyi oaaioeeoa?iiai /enea ? oaaioeeoa?iiai ?iaeaeno a 2,15 ? 4,49 ?ac?a a?aeiia?aeii. *enei INO iiceoeaieo AI c?inei a 3,16 ?ac, a ?o oao?acie??aa aeoeai?noue ae?inea a 1,45 ?ace, e?euee?noue aeeoo?caeaoieo AI ciaioeeanue a 1,51 ?ace. Oea iiaea aeacoaaoe ia aeeaieee c?ea eiiiainaoi?ieo iaoai?ci?a ooieoe?iiaeueii? aaeaioaoe??, yeee i?eaiaeeoue aei i?aeaeuaiiy ee??aino ee?oeiii? caaeaae?, ye ca ?aooiie iae?ico, oae ? ca ?aooiie aeoeaaoe?? i?ia?aiiaaii? ee?oeiii? caaeaae? (Sodja C. 1998). Oaeei /eiii, ni?eueiee aieea iiiieneaeo aoaeaoeth ? a?ia?oa?i??, aeyaey? iaea?eueo ae?aaeaio ae?th ia aeoeai?noue AI, ??cei i?eai?/oth/e ??. Aeoiaey/e c io?eiaieo aeaieo iiaeia i?eionoeoe, ui a eaaaiaa?e oeaiei? ca oiiae aieeao a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?nii? ae?? a?aeaoaaeiny ??cea i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? AI. Aaaioii, yeee aeeeeeaa iaeiaio? i?iyae ee?oeiii? caaeaae?, aeyaeany iiiieneae aoaeaoeth, a iaea?eueoee aieea aoa oa?aeoa?iee aeey noi?nii? ae?? a?ia?oa?i?? oa iiiieneaeo aoaeaoeth. Ii?yae c aea/aiiyi ii?oiooieoe?iiaeueieo ci?i a a?thaaoiio ai?oae?? a?iio?a, o?aoa? oa AI, i?iaiaeeeinue oaeiae aecia/aiiy eiioeaio?aoe?e i?inoaaeaiaeei?a A2 oa F2a a i?aa?e oa e?a?e eaaai?, oae ye a?ia?oa?i?y ? oaeoi?ii, eio?ee iiaea aieeaaoe ia a?ineioac ai?iii?a ? ai?iiiiiiae?aieo ?a/iaei (Knapp H.R. 1994). A oiiaao a?ia?oa?i?? ci?iththoueny i?ioeane neioaco ? eaoaaie?cio a?ieia?/ieo aeoeaieo ?a/iaei, ci?iththoueny aeanoeaino? ?o ?aoeaioi??a, iiaeoeth?oueny ?o a?ieia?/ia aeoeai?noue (Prado W.A. 1997). A oiiaao a?ia?oa?i?? ie aea/aee ??aaiue neioaco aeeicaii?ae?a ? oeeee?/ieo ioeeaioeae?a a eaaaiaa?e oeaiei? ? a oeaiei? ei?eiaiai ? iiceiaiai oa?o ie?ee uo?a. O aeaiiio aeine?aeaeaii? i?iaiaeeeany ii??aiyeueia oa?aeoa?enoeea iiaeeeainoae neioaco aeeicaii?ae?a oeaieiaie eaaaiue ? ie?ie ye aeaio iiaeeeaeo iaoaaie?/ieo i?ioeeaaeiinoae, oiio ui a?aeiii, ui a ie?eao a?aeaoaa?oueny iniiaiee neioac i?inoaaeaiaeei?a, a eaaai? aenooiathoue iaoaaie?/iei o?eueo?ii, a yeiio a?aeaoaa?oueny ?o aeacaeoeaaoe?y (Nally J.E. 1996). Aea i?e oeueiio a eaaaiyo ?nio? ? aacaeueiee ??aaiue neioaco i?inoaaeaiaeei?a. Iayai?noue aeoeaiiai neioaco eaeeio???i?a a eaaaiyo aaea anoaiiaeaia (Birks E.K. 1997, Hammarstrom S. 1985). O eaaaiyo iaie aeine?aeaeoaaany aacaeueiee ??aaiue a?ineioaco IAA2 ? IAF2a ? ?o aoi?eiieo iina?aaeiee?a oe-AIO ? oe-AIO. I?iaaaeaiiy aeine?aeaeaiiy a i?aa?e ? e?a?e eaaai? aoei iaoiiaeaia ?o aeayeeie ii?oiooieoe?iiaeueieie a?aei?iiinoyie. Oae, iaa?oue o eiio?ieuei?e a?oi?, ??aaiue neioaco IAA2 i?ae i?aaith ? e?aith eaaaiath aeinoia??ii a?ae??ciyany. Eiai ai?no a i?aa?e eaaai? ia?aaeuoaaa oaeee a e?a?e a 1,5 ?ac?a. O aeine?aei?e a?oi? i?ae aieeaii a?ia?oa?i?? neioac IAA2 ??cei c?inoaa (?en.2). Eiioeaio?aoe?y IAF2a a eiio?ieuei?e a?oi? aeinoia??ii ia a?ae??ciyeany i?ae i?aaith ? e?aith eaaaiath, aea ana ae eiai aiaeiaaiiee neioac aoa a?eueo ?ioaineaiei a i?aa?e eaaai?. O aeine?aei?e a?oi?, i?ney ia?aa??ao eiioeaio?aoe?y IAF2a c?inea a i?aa?e ? e?a?e eaaai? (?en.2). Ni?aa?aeiioaiiy eiioeaio?aoe?e oe-AIO a i?aa?e ? e?a?e eaaai? aoei ??ciei. O i?aa?e eiai ai?no ia?aaeuoaaa oaeee a e?a?e a 1,4 ?ace. I?ney ia?aa??aaiiy eiioeaio?aoe?y oe-AIO c?inoaea a?eueo i?ae a 3 ?ace, ye a i?aa?e oae ? e?a?e eaaai? (?en. 2). Aacaeueiee ??aaiue aiaeiaaiiiai neioaco oe-AIO a i?aa?e eaaai?, oaeiae ia?aaeuoaaa ??aaiue aacaeueiiai a?ineioaco a e?a?e (?en 2). I?e aecia/aii? ai?noo IAA2, IAF2a oa oe-AIO ? oe-AIO a oeaieiao ei?e ? iaaeoee ie?ee uo?a aoei anoaiiaeaii, ui a eiio?ieuei?e a?oi? eiioeaio?aoe?y IAA2 a ei?eiaiio oa iaaeoey?iiio oa?? ie?ie a?ae??ciyeenue a 960 ?ac?a, i?e/iio iniiaiee ai?no IAA2 aoa ca?a?no?iaaiee a iaaeoey?iiio oa?? ie?ie. O aeine?aeaeoaai?e a?oi? ai?no IAA2 c??n a ei?? a 8,8 ?ac, a iaaeoe? ie?ie - a 1,33 ?ace - ii??aiyii c eiio?ieueiith a?oiith. Iiae?aiei /eiii ci?ithaaeanue ? eiioeaio?aoe?y IAF2a. A eiio?ieuei?e a?oi? ai?no IAF2a a iiceia?e ?a/iaei? aoa o 57 ?ac?a a?eueoei, i?ae a ei?? ie?ee. I?e ia?aa??a? ai?no IAF2a a ei?? c??n a 1,65 ?ace, a iaaeoe? - 1,9 ?ac?a. ?en.2- ai?no i?inoaaeaiaeei?a A2, F2a oa oeeee?/ieo ioeeaioeae?a a eaaaiyo i?e ae?? a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?niiio aieea? Eiioeaio?aoe?y aoi?eiieo iina?aaeiee?a, oeeee?/ieo ioeeaioeae?a, (oe-AIO ? oe-AIO), ui iia’ycai? c ?aae?caoe??th neaiae?a /a?ac nenoaio i?inoaaeaiaeei?a A2 ? F2a, ci?ithaaeenue ?ioei /eiii. Aiae?c aenia?eiaioaeueieo aeaieo iieacaa, ui a ie?eia?e oeaiei? a eiio?ieuei?e a?oi? ai?no oe-AIO a iaaeoe? ia?aaeuoaaa oaeee a e??eia?e ?a/iaei? a 3 ?ace. I?ney ia?aa??ao eiai eiioeaio?aoe?y c?inea oaeei /eiii: o ei?? - 15,6 ?ace, a iaaeoe? - 2,6 ?ace. I?e aeine?aeaeaii? ai?noo oe-AIO, yeee ? aoi?eiiei iina?aaeieeii ae?? IAF2a, anoaiiaeaii, ui a eiio?ieuei?e a?oi? a?i a ei?? neeaaeaa 0,15 iiieue\ia a?eeo, ui a 6,4 ?ace iaioa, i?ae a i?ceia?e ?a/iaei?. O a?oi? aenia?eiaioaeueieo oaa?ei eiioeaio?aoe?y oe-AIO c?inoaea, ye a ei??, oae ? a iaaeoe? ie?ee. Ci?ie o ni?aa?aeiioaii? eiioeaio?aoe?e oeeee?/ieo ioeeaioeae?a(oe-AIO/oe-AIO), ye a eaaaiaa?e oae ? a ie?eia?e oeaiei?, iiaea na?ae/eoe i?i ooieoe?iiaeueio iia?e?caoe?th i?aaio ? caione i?ia?aie ee?oeiii? nia?o?, aai /a?ac iae?ic, aai ae /a?ac ?aae?caoe?th i?ia?aiiaaii? ee?oeiii? nia?o?. (Van Rijn J. 1996). A oiiaao oeaieiii? a?iien??, ui ?icaeaa?oueny o oaa?ei a aoiinoa?? c i?aeaeuaiith eiioeaio?aoe??th NI, i?ney aeniiceoe?? a eaia?? ai?no IAA2 ae??n a i?aa?e ? e?a?e eaaai? a 2,7 ? 1,9 ?ace a?aeiia?aeii (?en.2). Eiioeaio?aoe?y IAF2a a eaaaiyo a i?ioean? aenia?eiaioo oaeiae c?inoaea: a i?aa?e eaaai? - a 2,6 ?ac?a, a a e?a?e - a 1,2 ?ac?a (?en.2). Aieea NI aeeeeeaa cieaeaiiy ??aiy oe-AIO a i?aa?e eaaai? ii??aiyii c eiio?ieai a 1,8 ?ace, a a e?a?e cieaeaiiy aoei a?eueo aeeaieei - a 3,1 ?ace. Aeeiai?ea ci?i ??aiy oe-AIO i?aeoe/ii ia a?ae??ciyeany a?ae oaei? i?e ia?aa??a?. Eiai eiioeaio?aoe?y a i?aa?e eaaai? ae?inea a 4,2 ?ace, a a e?a?e - a 1,7 ?ace (?en. 2). Aeey ia?aa??ee i?eiouaiiy i?i noia?iee aieea a?iien?? ? a?ia?oa?i?? ia aeine?aeaeoaai? i?ioeane ie i?iaaee ii??aiyeueiee aiae?c aiaeiaaiiiai a?ineioaco i?inoaaeaiaeei?a ? ?o iina?aaeiee?a i?e noi?ni?e ae?? oeeo aaaio?a oa ?icae?eueieo aieea?a ia ieo a?ia?oa?i?? ? iiiiieeno aoaeaoeth. Noi?nia ae?y NI ? a?ia?oa?i?? iiaeaethaaeiny i?e ii?aeiaii? aeaio aeuaaeacaieo oiia. O aenia?eiaioaeuei?e a?oi? aiaeiaaiiee a?ineioac i?inoaaeaiaeei?a nooo?ai ci?ithaaany. O i?aa?e eaaai? neioac i?inoaaeaiaeeio A2 c??n a 2,5 a a e?a?e a 2,9 ?ace, i?e oeueiio ae aieea? neioac i?inoaaeaiaeeio F2a a i?aa?e eaaai? ae??n a 3,5, a a e?a?e a 2,9 ?ace (?en. 2). Ai?no oeeee?/ieo ioeeaioeae?a i?ney i?iaaaeaiiy aenia?eiaioo ci?ithaaany ?iaeoa. Eiioeaio?aoe?y oe-AIO ??cei c?inea: a i?aa?e eaaai? - a 4, a a e?a?e - a 10 ?ac?a. Aeeiai?ea ci?i oeeee?/iiai aoaiiceiiiiioinoaoo aoea oaeith ae, ye i?e ia?aa??aaii? ? aieea? NI, aea eiai ??aaiue a i?aa?e eaaai? cia/ii c??n (a 9 ?ac?a) ii??aiyii c eiio?ieai, a a e?a?e - a 16 ?ac?a (?en. 2). Io?eiai? aeai? i?aeoaa?aeaeothoue iaoa i?eiouaiiy i?i oa, ui oaeoi? a?ia?oa?i?? ? NI ?aae?cothoue nai? aoaeoe /a?ac noiae? iaoai?cie, iaeiei c yeeo ? aeoeaaoe?y aiaeiaaiiiai a?ineioaco i?inoaaeaiaeei?a ? nenoaie oeeee?/ieo ioeeaioeae?a. Iniaeeao oaaao i?eaa?oa? nenoaia oeeee?/iiai aoaiiceiiiiioinoaoo, ine?eueee eiai ?aaeoe?y ia oiiae aenia?eiaioo aoea iaea?eueo ae?aaeaiith. Oaeei /eiii, ia i?aenoaa? io?eiaieo ?acoeueoao?a iiaeia caeeth/eoe, ui ni?eueiee aieea NI ? a?ia?oa?i?? aeeeeea? a?eueo cia/i? ci?ie ee?oeiieo i?ioean?a a eaaaiaa?e oeaiei?. Nueiaiaei? ?niothoue ?iaioe, ui i?aeoaa?aeaeothoue cia/iee aieea NI ia oae? aaaeeea? iaoaaie?/i? i?ioeane, ye neioac oa?iaio?a, iai?eeeaae oeeoicieueii? aoai?eao-oeeeeace (Jourd'heuil D. 1997; Ia?eia O.I. 1996), oiui. Ee?oeiia caaeaaeue - i?ioean aaaaoia?aiiee yeee cae?enith?oueny ia ??cieo ??aiyo ee?oeiii? i?aai?caoe?? ? eiio?ieth?oueny ??ciiiai?oieie ?aaoeyoi?ieie iaoai?ciaie. Iaeiei c oaeeo oaeoi??a ? ? eaeeio???ie (Krajcsi P. 1996) Ia no/aniiio aoai? ?niothoue iacaia?a/i? aeieace aieeao ai?iii?a, cie?aia aetheiei?oeei?ae?a (AE), ia ?icaeoie i?ia?aiiaaii? ee?oeiii? caaeaae? a oeiioeeoao (Schwartsman R.A. 1994). A oeiioeeoao, ye? aoei ia?iaeaii AE, aoea aeyaeaia o?aaiaioaoe?y ee?oeiiiai yae?a c inoaoi/iei ?iciaaeii AeIE i?ae aieeaii yaea?ieo aiaeiioeeaac (Wyllie A.H. 1980). Iiaeeeaeie iaoai?ciaie, ui aeeeeeathoue aiiioic i?ae ae??th AE ? aeni?an?y eaeueiiaeoe?io c iiaeaeueoei c?inoaiiyi eiioeaio?aoe?? aioo??oiueiee?oeiieo ?ii?a Na2+, aeoeaaoe?y i?ioiiieiaai?a c iiaeaeueoith ci?iith ee?oeiiiai oeeeeo, cieaeaiiy i?iaeoeoe?? ?ioa?eaee?i?a ? ?ioeo oeeoie?i?a (Baughman G. 1997; Helmberg A. 1995). I?ioa ?ieue ? iaoai?cie ae?? ?ioeo ai?iii?a aeine?aeaeai? iaaeinoaoiuei. Oiio iniaeeaee ?ioa?an aeeeeea? aeine?aeaeaiiy noaio ai?iii?a a?iio?co, iae?iai?iii?a, ai?iii?a, ui ?aaoeththoue ??aaiue ?ii?a Na+ ? Na2+ a ieaci? e?ia? ? ie?eao. Iaoith oeeo aeine?aeaeaiue aoei aecia/eoe, yeei /eiii aiaeie?eiia nenoaia ?aaao? ia oiiae, ye? aaaeooue aei ?icaeoeo ee?oeiii? caaeaae?. ?iie Na2+ oaeiae ?aaoeththoue ia o?eueee i?ioeane aea?eueiaiiy ai?iii?a, aea ? nai? a eiiieaen? c eaeueiiaeoe?iii aenooiathoue iina?aaeieeaie a ?aae?caoe?? ai?iiiaeueii? a?aeiia?ae? (Oaiia?iai Ae. 1989). E??i oiai, aiie ? iaeiei c oaeoi??a cai?oaiiy e?ia?, aoiaeyoue aei neeaaeo e?noeiai? oeaieie, ? ?iaeoeoi?aie aiiioico (Nicotera P. 1986). I?ioa ieoaiiy, yeei /eiii oiiae ui aeeeeeathoue ?icaeoie ee?oeiii? nia?o?, aieeaathoue ia aaeain ai?iii?a, ui ?aaoeththoue eiioeaio?aoe?th ?ii?a Na2+ a ieaci? e?ia? (IOA oa eaeueoeeoii?io) caeeoa?oueny a?aee?eoei. O iaoiio aenia?eiaio? a oiiaao a?ia?oa?i?? eiioeaio?aoe?y IOA c?inoaea a 1,6 ?ace i?e i?aeoe/ii iaci?ii?e eiioeaio?aoe?? ne?iaaoeiaiai eaeueoeeoii?io. Aeaia c?inoaiiy eiioeaio?aoe?? IOA niinoa??aaeiny ia oii? c?inoaiiy eiioeaio?aoe?? Na2+ a ieaci? e?ia? ia 10% ? cieaeaiiyi eiai ai?noo a iaaeoe? ie?ie oaeiae ia 10%. Iae?iia??i?oa, a?aeaoaa?oueny noeioeueiaaia a?ia?oa?i??th aai ae ?? iane?aeeaie, oaeeie ye i?aeaeuaiiy eiioeaio?aoe?? AE (aiane?aeie aeeeaeo AEOA) ? eaoaoieai?i?a, ?aaeoe?y, a i?ioean? yei? iiina?aaeeiaaii (/a?ac aaeueioaaiiy aniieooaaiiy eaeueoe?th a eeoa/ieeo) ? aaciina?aaeiuei (/a?ac b-?aoeaioi?e ia?aueoiaeaeieo ee?oei) a?aeaoaa?oueny noeioeyoe?y nae?aoe?? IOA, aiane?aeie /iai a?aeaoaa?oueny c?inoaiiy ieaciiai? eiioeaio?aoe?? ?ii?a Na2+. (Oaiia?iai Ae. 1989). Ia?aa??aaiiy i?aai?cio ? no?anii, iniiaieie i?iyaaie yeiai ? i?aeaeuaiiy eiioeaio?aoe?e AE. Iniiaio ?ieue a i?ioean? ?aaoeyoe?? ??aiy AE a e?ia? aeeiio? AEOA. Ooieoe?iiaeueiee noai iaaeie?iee?a iiaea a?aeaeaaoeny /a?ac aeeiai?eo ci?ie eiioeaio?aoe?? a e?ia? iniiaiiai ?aaoethth/iai oaeoi?a ?o ai?iii?a - AEOA. ?en.3. Eiioeaio?aoe?y ai?iii?a a ne?iaaooe? e?ia? i?e aieea? a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?ni?e ae?? A aenia?eiaio? i?ney ia?aa??ao eiioeaio?aoe?y AEOA a ne?iaaooe? e?ia? ae?inea a 2,4 ?ace, ui aeicaiey? neacaoe, ui i?e aeaiiio aieea? aeoeai?noue AE, ye a ne?iaaooe?, oae ? a oeaieiao i?aai?cio, aoaea i?aeaeuaiith. E??i oiai, iaeiei c aoi?eiieo aoaeo?a AEOA ? ?aaoeyoe?y nae?aoe?? iaaeie?ieeaie i?ia?aeiei?oeei?ae?a (aeueaeinoa?iio). O aeiaaeeo c ia?aa??aaiiyi AEOA a?ae?a?a?, nei??o ca ana, ?ieue ioneiaiai oaeoi?a nae?aoe?? aeueaeinoa?iio. Aea oaea ??cea i?aeaeuaiiy eiioeaio?aoe?? aeueaeinoa?iio (a 4 ?ace) aaaeei iiynieoe o?eueee i?aeeiiii eiioeaio?aoe?? AEOA. Eiai eiioeaio?aoe?y a e?ia? eiio?ieth?oueny ? ?yaeii ?ioeo oaeoi??a. Aei oaeeo oaeoi??a a?aeiinyoueny ??aaiue ?ii?a Na+ a ieaci? e?ia?, iniiey?i?noue ieacie, ??aaiue nae?aoe?? ?ai?io oa aea?eueiaiiy aia?ioaiceio. Oea i?eiouaiiy aoei i?aeoaa?aeaeaia ?acoeueoaoaie aeine?aeaeaiiy ?ioeo oaeoi??a, ui ?aaoeththoue eiioeaio?aoe?th aeueaeinoa?iio a e?ia?. Aoea aecia/aia aeoeai?noue ?ai?io ieacie, yea i?e a?ia?oa?i?? c?inoaea a 2,8 ?ac?a (?en. 3). Ai?no ?ai?io a e?ia? oa eiai aeoeai?noue caeaaeeoue a?ae ie?eiaiai e?iaioieo, a?ae ??aiy a?ineioaco oeeoie?i?a (IAA2), a?ae noaio aeoeaiino? oa?iaioieo nenoai oeo i?aai?a, a yeeo a?aeaoaa?oueny eiai nae?aoe?y. Iane?aeeii ?iaioe nenoaie ?ai?i-aia?ioaicei-aeueaeinoa?ii (?AA) a iaoiio aenia?eiaio? aoei i?aeaeuaiiy eiioeaio?aoe?? ne?iaaoeiaiai iao??th ia 20% a?ae ii/aoeiaiai ??aiy. Aiaeiaaii? ii?i?aee ? oeie iae?iiaioeaeaie, ia ye? iieeaaeathoueny ooieoe?? ?ioaa?aoe?? ? aca?iiae?? i?ae aoii?aeueii? ? ia?aiaith nenoaiaie. Oe?eei ?yaeii ?ia?o anoaiiaeaia ?ieue aeciaaiieo ii?ao?a a ?icaeoeo ? noeioeyoe?? aiiioico (Yin DL. 1997; Singhal PC.? 1997). Aea aeine?aeaeaiue noaio nenoaie aiaeiaaiieo ii?i?ae?a a oiiaao noeioeyoe?? ee?oeiii? caaeaae? i?aeoe/ii ia i?iaiaeeeiny. A aeine?aeaeaiiyo, ui i?iaiaeeeeny a iaoiio oeaio?? ?ai?oa, anoaiiaeaia ?ieue ? aieea ii?i?ae?a ia neioac i?inoaaeaiaeei?a ? noai aiaeii-nieueiaiai aaeaino a ie?eia?e oeaiei?. Aiie aeyaeyee aioeiao??eo?aoe/io ae?th ? aaeueioaaee ae?iaeaiiy i?inoaaeaiaeei?a (Eociaoeiaa A.A. 1994; Eiia?aaoeaaa E.I.1992). Cieaeaiiy ??aiy iao-aieaoae?io a oiiaao ee?oeiii? caaeaae? ? eiiiainaoi?ii-i?eniiniaethaaeueiith ?aaeoe??th, aiaeia?/ii neioaco AOO, ?acoeueoaoii yei? iiaeiii aooe cieaeaiiy i?iya?a ee?oeiii? caaeaae? ia o?eueee a nai?e ee?oei? aai ?o eoeueoo??, aea ? a i?aai?ci? a oe?eiio. A?aoiaoth/e oa, ui o AEOA ? aiaeiaaiieo ii?ao?a ? ni?eueiee iiia?aaeiee, oi iiaeia ia?aaeaa/eoe, ui cieaeaiiy ?o eiioeaio?aoe?e a ieaci? e?ia? coiiaeaia iaaaoeaiei cai?ioiei ca'yceii AEOA c i?iii?iiaeaiiei?oeiii aai c eiai iiaeaeueoeie iaoaaie?oaie (Shreiber V. 1994). I?e ae?? NI oaeiae aoei aeine?aeaeaii eiioeaio?aoe?? AEOA, iao-aieaoae?io, IOA, eaeueoeeoii?io, aeueaeinoa?iio, A?I, c iaoith aecia/aiiy iiaeeeai? ?ie? Nye neaiaeueii? iieaeoee a i?ioeanao aoii?aeueii? ?aaoeyoe?? ee?oeiii? caaeaae?. Ae?y iiiieneaeo aoaeaoeth ia noai aiaeie?eiii? nenoaie i?aai?cio aeyaeeany a?eueo ae?aaeaiith, i?ae aieea a?ia?oa?i??. I?ney i?iaaaeaiiy aenia?eiaioo niinoa??aaeiny cieaeaiiy ai?noo AEOA a ne?iaaooe? e?ia? (a 2,2 ?ace) oa eiioeaio?aoe?? iao-aieaoae?io (a 1,3 ?ace) ii??aiyii c eiio?ieai (?en 3). Oaea ?aaeoe?y AEOA ia ae?th NI iiaea aooe iiyniaia ciaioaiiyi aeoeaiino? nenoai neioaco. Ii?ooaiiy oeueiai i?ioeano ? ii/aoeii ?icaeoeo a ee?oei? i?ioean?a ee?oeiii? caaeaae?, i?e yeiio ee?oeia ao?a/a? nai? iniiaia ooieoe?iiaeueia i?ecia/aiiy. Io?eiai? aeai? na?ae/aoue i?i o/anoue NI a nenoai? ia?aaea/? neaiaeo a?ae ee?oeiieo ?aoeaioi??a aei aaiaoe/iiai aia?aoo ee?oeie. Iiae?aiee oaeo aoa anoaiiaeaiee i?e ii??aiyii? c ae??th NI oa NO ia a?iio?c (Rivier C. 1998). Aea/aiiy aieeao NI ia eiioeaio?aoe?? iniiaieo ai?iii?a, ui ?aaoeththoue eiioeaio?aoe?th ?ii?a eaeueoe?th a ieaci? e?ia?. (?en. 3) iieacaei, ui iathoue i?noea ii?ooaiiy ye? ? i?ioeeaaeieie aei oeo, ye? aoee anoaiiaeai? i?e ae?? a?ia?oa?i??. Eiioeaio?aoe?y IOA cieceeany (a 3,5 ?ace) ? i?aeoe/ii aea?aaeaioii c?inea eiioeaio?aoe?y eaeueoeeoii?io (a 3,7 ?ace), ui iiaea nei??o ca ona na?ae/eoe i?i c?inoaiiy eiioeaio?aoe?? ?ii?a Na2+ a ieaci?, ? aeaiee aoaeo iiaeia ?icaeyaeaoe ye eiiiainaoi?io ?aaeoe?th i?aai?cio ia i?aeaeuaiiy eiioeaio?aoe?? ?ii?a Na2+. Ae?y NI i?ecaiaeeea aei ci?ie iieaciee?a ?AA nenoaie: eiioeaio?aoe?y aeueaeinoa?iio ae?inea a 13,6 ?ac?a ,a A?I - a 3,9 ?ac?a (?en.4) a ii??aiyii? c eiio?ieai. Io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui ?a/iaeiaie, ye? ?aaoeththoue ai?no eiiiiiaio?a ?AA nenoaie a ieaci? e?ia? aenooia? ? NI. Oe? aeai? ca?aathoueny c ?acoeueoaoaie c i?aeaeuaiiy ieaciiai? aeoeaiino? ?ai?io i?ney aeniiceoe?? oaa?ei a aoiinoa?? NI ? IAA2 (Kramer BK.1998; Eociaoeiaa A.A. 1994). Ine?eueee eiai eiioeaio?aoe?y ? a eaaaiyo, ? ie?eao cia/ii c?inea, ieaciiaa eiioeaio?aoe?y oaeiae aoaea aenieith, ? a?i ciiaea ?aae?coaaoe nai? aeanoeaino? ye ai?iii, ?aaoethth/e aeoeai?noue ?AA nenoaie. Ii?aeiaiiy ae?e a?ia?oa?i?? oa NI aoei iiaeaeeth, eiee a oiiaao ?icaeoeo ee?oeiii? nia?o? (a?ia?oa?i?y) aei ee?oei aeinoaaeyany NI. Ioe?ithth/e ea?oeio ai?iiiaeueiiai niaeo?o, iaiao?aeii aoei a?aoiaoaaoe iiaeeea?noue aieeao oeeoie?i?a, NO, aeeicaii?ae?a ia ai?no ai?iii?a a ieaci? e?ia? a oiiaao noeioeueiaaii? ee?oeiii? caaeaae?, ine?eueee ?niothoue aeai? i?i iiaeeeao aeoeaaoe?th ?iaeooeeaaeueii? NO-neioaoace NI, c iiaeaeueoei aeeth/aiiyi a eaioetha oeaieiieo i?ioean?a iieaeoee NO (Chiarugi V.1998). Nai NI, e??i oiai, ? noeioeyoi?ii ?iaeooeeaaeueii? oeeeeiieneaaiace-2, ui iaoiiaeth? iineeaiiy a?ineioaco IAA2 i?aeoe/ii o an?o oeaieiao i?aai?cio (Kostoglou-Athanassiou I. 1998). Oaeiae ?niothoue aeai? i?i aeoeaaoe?th nenoaie ?ioa?eaee?i?a a oiiaao ?icaeoeo ee?oeiii? caaeaae? i?ae aieeaii NI (Li WX. 1998). I?ney i?iaaaeaiiy aenia?eiaioo eiioeaio?aoe?y AEOA cieceeany a 1,6 ?ac?a, a ai?no iao-aieaoae?io a 2,4 ?ace ii??aiyii c eiio?ieai (?en.3). Aeaia ciaioaiiy eiioeaio?aoe?e iae?iai?iii?a iiaea na?ae/eoe aai i?i aeniaaeaiiy ee?oeiieo nenoai, ui aeae?eythoue ?o, aai i?i oa, ui a ee?oeiao ?icaeioeeny ci?ie, ye? ? ia noi?ni? c aeeiiaiiyi aeanoeaeo aeey ieo ooieoe?e (Maines M.D. 1995). Ia ei?enoue oeueiai i?eiouaiiy na?ae/eoue oaeiae ii?ooaiiy a nenoai? ?aaoeyoe?? eaeueoe?th, ui ae?aaeathoueny a cieeiaii? ?aoeei?ieieo aca?iia?aeiinei i?ae aeaiia ai?iiiaie, ye? ?aaoeththoue eiioeaio?aoe?th ?ii?a eaeueoe?th a ieaci? e?ia?, ui ae?aaea?oueny a i?aeaeuaii? eiioeaio?aoe?e ye IOA, oae ? eaeueoeeoii?io a a?e c?inoaiiy eiioeaio?aoe?? eaeueoeeoii?io (?en.3). Noai ?AA nenoaie ? ni?aa?aeiioaiiy i?ae ?? eiiiiiaioaie oaeiae ci?ithaaeiny. Eiioeaio?aoe?y aeueaeinoa?iio ae?inea a 9,2 ?ac?a, a A?I — a 4,6 ?ac?a (?en.3). Aacoth/enue ia inoaii?o aeaieo e?oa?aoo?e oa aeaieo, ye? aoei io?eiaii a ?iaio?, iiaeia i?aenoioaaoe, ui iiiieneae aoaeaoeth ? i?inoaaeaiaeeie aenooiathoue iaeii/anii ye o?eaa?e ? aioo??oiueiee?oeii? ianaiaeaea?e a i?ioean? caioneo ? ?icaeoeo ee?oeiii? caaeaae?, aea NI ? i?inoaaeaiaeeie, caeeoath/enue ?aeeiith ?aaoeyoi?iith nenoaiith, aeeiiothoue ??ciini?yiiaai? ooieoe??. Aeeiioth/e ooieoe?? aioo??oiueiee?oeiieo ianaiaeaea??a aiie /eiyoue ? aeoeaoth/ee ? ?ia?aoth/ee aieea ia aaiiee aia?ao ee?oeie, eiio?iethth/ee ?icaeoie ee?oeiii? caaeaae?. A oeueiio i?ioean? iiaeooue aooe caae?yi? NO, NI, oeeeeiieneaaiaca, aaiieneaaiaca, IAA2 ? IAF2a, oiio ui a iaaeaai?o aeine?aeaeaiiyo aoa aeyaeaiee aieea NI ia aeoeai?noue oeeeeiieneaaiace, a yeiio a?aeaoaaeiny i?aeaeuaiiy ?? aeoeaiino? c iiaeaeueoei i?aeaeuaiiyi ooai?aiiy i?inoaaeaiaeei?a (Mancuso C. 1998; Satta M.A. 1998). AENIIAEE Ia?aa??aaiiy i?aai?cio (aei 41-43°C), aieea iiiieneaeo aoaeaoeth oa ?o noi?nia ae?y aaaeooue aei caaeaae? ee?oei a?thaaoiai ai?oae?th a?iio?a, ie?eiai?, ia/?ieiai? oa eaaaiaai? oeaiei. I?ae aieeaii iiiieneaeo aoaeaoeth, a?ia?oa?i?? oa ?o noi?nii? ae?? a?aeaoaa?oueny c?ooaiiy iaoaaie?cio iie?iaiane/aieo aee?ieo eeneio, ui ae?aaea?oueny a c?inoaii? oeaieiii? eiioeaio?aoe?? i?inoaaeaiaeei?a A2 oa F2a a i?aa?e oa e?a?e eaaai?. A oiiaao aieeao a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?nii? ae?? a eaaaiaa?e oeaiei? a?aeaoaa?oueny ??ciini?yiiaaia ci?ia eiioeaio?aoe?e oeeee?/ieo ioeeaioeae?a a a?e cieaeaiiy oe-AIO oa c?inoaiiy oe-AIO. Aacaeueia oa noeioeueiaaia a oiiaao aenia?eiaioo eiioeaio?aoe?? i?inoaaeaiaeei?a oa oeeee?/ieo ioeeaioeae?a a i?aa?e eaaai? ia?aaeuothoue oae? a e?a?e. O ai?iiiaeuei?e a?aeiia?ae? i?aai?cio i?e ae?? iiiieneaeo aoaeaoeth, a?ia?oa?i?? oa ?o noi?ni?e ae?? a?aeaoaa?oueny ??ciiiai?aaeai? c?ooaiiy aiaeie?eiieo iaoai?ci?a ?aaoeyoe?? eiioeaio?aoe?? ?ii?a eaeueoe?th ieacie e?ia?. I?aeaeuaiiy aeoeaiino? ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie c ?icaeoeii neiae?iio a?ia?iao???i?? aeacothoue ia ii?ooaiiy aiaeii-nieueiaiai aiiainoaco, ui ni?ey? ?icaeoeo ee?oeiii? caaeaae?. Ae?y iiiieneaeo aoaeaoeth oa eiai ii?aeiaiiy c a?ia?oa?i??th aaaea aei cieaeaiiy eiioeaio?aoe?? iao-aieaoae?io, cia/iiai ciaioaiiy ai?noo AEOA a ne?iaaooe? e?ia?, ui aeaco? ia c?ea aaeaioaoe?eieo iaoai?ci?a a no?ani?ieo ai?iiiaeueieo nenoaiao. Ae?y iiiieneaeo aoaeaoeth oa eiai noi?niee aieea c a?ia?oa?i??th aeeeeeathoue c?inoaiiy ieaciiai? eiioeaio?aoe?? IOA, eaeueoeeoii?io, ?ii?a Na2+ oa Na+, cieaeaiiy ieaciiai? eiioeaio?aoe?? iao-aieaoae?io oa AEOA, c?inoaiiy oeaieiii? eiioeaio?aoe?? i?inoaaeaiaeei?a, oe-AIO cieaeaiiy oeaieiii? eiioeaio?aoe?? oe-AIO, ui ni?ey? ?icaeoeo ee?oeiii? caaeaae?. Nienie ?ia?o iioae?eiaaieo ca oaiith aeena?oaoe?? E. A. Eiia?aaoeaaa, A. A. ?iuoieei, A. I. Eiia?aaoeaa, I. A. Iaianaiei, A. I. Nai/ee "Eciaiaiea iaoaaieecia i?inoaiieaeia i?e eenoiciii ii?aaeaiee ii/ae" // Oe?aeineee aeioeie/aneee aeo?iae, 1997, ? 5-6 , o. 69, N. 168-176. E.A. Eiia?aaoeaaa, A.I. Nai/ee. Iniaaiiinoe yiaeiaaiiiai aeineioaca i?inoaaeaiaeeiia A2 e F2a oeaiyie e?aeeo a oneiaeyo aeiienee e aeia?oa?iee // Oe?aeineee aeioeie/aneee aeo?iae.- 1998.- O.70.-? 5.- N.117-121 Nai/?e A.I. Iiiieneae aoaeaoeth - ye iaeei ?c iiaeeeaeo /eiiee?a a ?icaeoeo i?ia?aiiaaii? ee?oeiii? nia?o? // Oe?a?inueeee iaaee/iee aeueiaiao.- 1998.- ?4.- N.110-113 Nai/ee A. I., Iaianaiei I. A., Eiia?aaoeaaa E. I. ?ieue ia?aa?aaa, iiiieneaea oaea?iaea, e i?inoaaeaiaeeia A2, a iiin?aaeiaaiee aiiioica, e eo aeeyiea ia no?anni?ii-aaeaioaoeeiiioth nenoaio iao-yieaoaeei-AEOA i?e yenia?eiaioaeueiii eiaeooee?iaaiee i?ia?aiie?oaiie eeaoi/iie aeaaee // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??.- 1998.- Aei.3.- N.260-269 A.I.Nai/ee "Aeia?oa?iey eae oaeoi? ?acaeoey i?ia?aiie?oaiie eeaoi/iie aeaaee" I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??, 1998, Aei.2, N.265-273 A.I.Nai/ee E.I.Eiia?aaoeaaa "Ninoiyiea aeiioaeaii-aeiioeca?iie, ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoai e ai?iiiia, ?aaoee?othueo eiioeaio?aoeeth eiiia eaeueoeey a oneiaeyo eeaoi/iie aeaaee" // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??, 1999, Aei.21(1), N.210-219 A. I. Nai/?e Iniaeeaino? aiaeiaaiiiai a?ineioaco aeeicaii?ae?a a oeaieiao eaaai?a oa ie?ie // O?c?ieia?/iee aeo?iae.- 1998.- ?3.- O. 44.- N.12. V.Senchiy I. Komarevtseva The role of carbon monoxide in the development of program cell death.. // 4th International Medical Students Congress: Nov. 5-8, 1998, Katowice, Poland. Nai/?e A.I. Aieea iiiieneaeo aoaeaoeth oa a?ia?oa?i?? ia neioac aeeicaii?ae?a oa ai?iii?a, ui ?aaoeththoue caaeaaeue ee?oei a eaaaiaa?e oeaiei? -?oeiien Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 03.00.04 - a?io?i?y.- ?inoeooo aa?iioieia?? Aeaaeai?? Iaaee/ieo Iaoe Oe?a?ie, Ee?a, 1999 ?. Aeena?oaoe?th i?enay/aii ieoaiiyi ?ie? oa o/ano? iiiieneaeo aoaeaoeth oa a?ia?oa?i?? a iaoai?ciao ?icaeoeo ee?oeiii? caaeaae?. A ?acoeueoao? aenia?eiaioaeueieo aeine?aeaeaiue aeyaeaii iia? oeyoe aca?iiae?? i?ae iieaeoeaie iiiieneaeo aoaeaoeth, i?inoaaeaiaeei?a oa oeeee?/ieo ioeeaioeae?a a i?ioean? ?aaoeyoe?? ee?oeiii? nia?o?. I?ae aieeaii a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?nii? ae?? a eaaaiaa?e oa ie?eia?e oeaieiao c?inoaee oeaieii? eiioeaio?aoe?? i?inoaaeaiaeei?a A2 oa F2a. I?iaeaiiino?iaaia a?aei?ii?noue a ??aiyo aacaeueiiai oa noeioeueiaaiiai a?ineioaco i?inoaaeaiaeei?a oa oeeee?/ieo ioeeaioeae?a i?ae i?aaith oa e?aith eaaaiath. Anoaiiaeaia aeeiai?ea ci?i iae?iai?iii?a, AEOA, ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? oa eaeueoe?e-?aaoethth/i? ai?iiiaeueieo nenoai a oiiaao aeieeiaiiy ee?oeiii? nia?o? a eaaaiaa?e oeaiei?. Eeth/ia? neiaa: a?ia?oa?i?y, iiiieneae aoaeaoeth, iiiieneae acioo, i?inoaaeaiaeeie, ee?oeiia caaeaaeue, ai?iiie, ?aaoeyoe?y. Senchiy V.N. The iecosanoids and hormones synthesis under carbon monoxide and hyperthermia influence, which are cell death regulators in lung tissue. -Manuscript The dissertation for receiving candidate Medical sciences degree for speciality 03.00.04 - biochemistry- Gerontology Institute Academy of Medical Sciences Ukraine, Kiev, 1999 y. The study of carbon monoxide and hyperthermia participation in developing mechanisms of cell death is the main task of this study. We show a new interaction ways between carbon monoxide, prostaglandins and cyclic nucleotide in the cell death regulation. The tissue concentration of prostaglandin E2 and F2a were increased under hyperthermia, carbon monoxide and its combination influence. We show the distinction in the basal and stimulated levels in the prostaglandins and cyclic nucleotides contents between right and left lung. The neurohormonal systems, ACTH, renin-angiothensin-aldosterone and calcium blood level hormone systems activities and its changes due to cell death condition were determined too. Key words: hyperthermia carbon monoxide, nitrogen monoxide, prostaglandins, cell death, hormones, regulation. Nai/ee A.I. Aeeyiea iiiieneaea oaea?iaea e aeia?oa?iee ia neioac aeeicaiieaeia e ai?iiiia, ?aaoee?othueo eeaoi/ioth aeaaeue a eaai/iie oeaie - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 03.00.04 - aeioeiey.- Einoeooo aa?iioieiaee Aeaaeaiee iaaeeoeeineeo Iaoe, Oe?aeia, Eeaa, 1999a. Aeenna?oaoeey iinayuaia eco/aieth ?iee e ianoa iiiieneaea oaea?iaea e aeia?oa?iee a i?ioeannao ?acaeoey e ?aaoee?iaaiey eeaoi/iie aeaaee. A ?aaioa i?iaiaeeony aiaeec eciaiaiee neioaca i?inoaaeaiaeeiia a ii/a/iie e eaai/iie oeaie, o?iaiy eeaoi/iie aeaaee n ni/aoaieai eciaiaiee nenoaiu ianoiiai eiioieoaoa e aoii?aeueiie nenoaiu a oneiaeyo noeioee?iaaiiie eeaoi/iie aeaaee. Yenia?eiaio i?iaiaeeeny ia 220 e?unao eeiee Wistar 3-o iany/iiai aic?anoa n iannie 200-250 a?, eioi?ua auee ?acaeaeaiu ia 4 a?oiiu (3-yenia?eiaioaeueiua e 1 - eiio?ieueiay). A yenia?eiaioa aeeaioiua iiaeaa?aaeenue aeia?oa?iee (+43 - +45°N), aicaeaenoaeth iiiieneaea oaea?iaea e eo niaianoiiio aeaenoaeth. A yenia?eiaioaeueiuo e eiio?ieueiuo a?oiiao ?aaeeieiioiieiae/aneei iaoiaeii i?iaiaeeeenue enneaaeiaaiey i?inoaaeaiaeeiia (IA) A2 e F2a, oeeeee/aneeo ioeeaioeaeia (oeAIO, oeAIO) - a i?aaii e eaaii eaaeii, ai?iiiia (AEOA, iao-yieaoaeei, IOA, eaeueoeeoiiei, aeueaeinoa?ii, aeoeaiinoue ?aieia ieaciu) - a nuai?ioea e?iae. Iaoiaeii iinoaiiaee INO-oanoa, iiaen/aoa oaaioeeoe?othueo aeueaaiey?iuo iae?ioaaia (AI) ii?aaeaeyee ooieoeeiiaeueioth aeoeaiinoue AI, a oaeaea ii?aaeaeyee eiaeaen aeaaaia?aoeee ia?oeaoaeueiiai yieoaeey a o?aoaa, i?aaii e eaaii eaaeii. Aeey iiaeoaa?aeaeaiey eeaoi/iie aeaaee auee naeaeaiu yeaeo?iiiua iee?ioioia?aoee a ii/eao, eaai/iie oeaie, ia/aie. A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee, auei onoaiiaeaii, /oi a eeaoeao ii/ae, eaaeeo e ia/aie iinea ia?aa?aaaiey eiaea ianoi aeaceioaa?aoeey aioo?eeeaoi/iuo no?oeoo? n i?eciaeaie eeaoi/iie aeaaee. A yieoaeee a?iioia e o?aoae i?e ii?aaeaeaiee eiaeaena aeaaaia?aoeee ia?oeaoaeueiiai yieoaeey auei ii?aaeaeaii, /oi ieieiaeueiia iia?aaeaeathuaa aeaenoaea ieacuaae NI, iaeneiaeueiia - aeia?oa?iey. Aeaaeue yieoaeey a i?aaii a?iioa i?aiaeaaeaea iaae eaaui. I?e yoii aea iaaethaeaeinue nieaeaiea ooieoeeiiaeueiie aeoeaiinoe AI, /oi auei iaoneiaeaii ?acaeoeai i?ioeannia aeaaee. I?e ii?aaeaeaiee IA a ii/a/iie e eaai/iie oeaie, auei onoaiiaeaii, /oi neioac IA a ii/eao niecia?ei n oaeiaui a eaaeeo. Iinea i?iaaaeaiey yenia?eiaioa neioac IAA2 e IAF2a a eaaeeo aic?anoae ai anao yenia?eiaioaeueiuo a?oiiao: aeia?oa?iey

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