1

AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO AIAeIE?EIIEIA?? OA IAI?IO ?A*IAEI ?I. A.I.EII?NA?AIEA

Ie?eieeiaa Na?oeaia Iao??aia

Aieea ?ioaineaii? cai?nii? oa?ai?? L–oe?ieneiii noi?nii c aioaaii?noii
eaeueoe?th (ei?aeaoaiii) ia ooieoe?iiaeueiee noai na?oeaai-noaeeiii?
nenoaie i?e a?iioe?aic?

14.01.14 – AIAeIE?EIIEIA?ss

aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a -1999

Aeena?oaoei?th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio ?inoeooo? oaeineiiaeaiiy e?ea??a IIC
Oe?a?ie, Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo oa?iaeioa?ai??
aiaeie?eiieo caoai?thaaiue

Iaoeiaee ea?iaiee: A?eaoeueea Ieueaa Ieoaee?aia, aeieoi? iaaee/ieo iaoe,
Oa?e?anueeee ?inoeoo oaeineiiaeaiiy e?ea??a, caa?aeoth/a
eaoaae?ith aiaeie?eiieia??.

Ioioeieii iiiiaioe: Aiaeia? Iao?i Ieeieaeiae/, aeieoi? iaaee/ieo iaoe,
i?ioani?, Iaoe?iiaeueiee iaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey,
caa?aeoth/ee eaoaae?ith aiaeie?eiieia??

Cae?inueeee Ai?en Ieaen?eiae/, aeieoi? iaaee/ieo iaoe, i?ioani?,
A?iieoeueeee iaaee/iee oi?aa?neoao ?i. I.?.Ie?iaiaa, caa?aeoth/ee
eaoaae?ith aiaeie?eiieia??

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.
Ae.Aaeeoeueeiai , eaoaae?a aiaeie?eiieia??.

Caoeno aiaeaoaeaoueny “ 2 “ ethoiai 1999 ?. i 13 aiaeeii ia caniaeaiii
niaoeiaeiciaaii? a/aii? ?aaee Ae 26.558.01 Iinoeoooo aiaeie?eiieia?? oa
iai?io ?a/iaei AII Oe?a?ie (254053, i. Ee?a, aoe.Aeoai?iaenueea 69).

C aeena?oaoei?th iiaeia iciaeiieoeny o aiaeiioaoei Iinoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei AII Oe?a?ie (254053, i. Ee?a, aoe.
Aeoai?iaenueea 69).

Aaoi?aoa?ao ?icineaiee “ 29 “ a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoeiaeiciaaii? a/aii? ?aaee,

aeieoi? a?ieia?/ieo iaoe
E.I. Eaeeinueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue oaie. Iaiaoiaeiinoue oaeineiiaeaiiy iaoiaeia caiinii?
oa?aii? oe?ai?aeii? iaaeinoaoiinoi iaaoaa? aaaeeeaiai cia/aiiy o ca’yceo
ic c?inoaiiyi eieueeinoi oai?eo ia ia?aeiiee aiiioe?aic oa
iaaeinoaoiueith aoaeoeaiinoth eiai eieoaaiiy.

Oae, ia i?ioyci aeiaaiai /ano aeei?enoaiiy ??cieo iaoiaeee e?eoaaiiy
oe?ai?aeeiii ia aeaei aaaeaieo ?acoeueoao?a. Ai?iaaaeaeaiiy a i?aeoeeo o
60-70-o ?ieao neioaoe/iiai O3 oa eiiaiiiaaieo oe?ai?aeieo i?aia?aoia
(oe?aioiio oa oe?aieiiao) oaeiae ia aeicaieeei aeinyaoe o oai?eo ia
aiiioe?aic aeinoaoiuei aeniei? oiea?aioiinoi aei caiinii? oa?aii?
[J.Baillet et al.,1981], o ca’yceo c /ei iaaoea oe?ieiai
?iciianthaeaeaiy iaoiaeeea «iaeeo» aeic oe?ai?aeieo ai?iiiia ia ii/aoeo
eieoaaiiy aiiioe?aico [O.Oaiaao ic niiaaao., 1988; I.O.Noa?eiaa, 1991;
H.Bethge, 1984].A iiaeaeueoiio o oai?eo c oe?ai?aeiith iaaeinoaoiinoth
aoea aeyaeaia aieueo aeniea ia?aiineiinoue L-oe?ieneio (L-O4).
Anoaiiaeaii, ui i?e eiai i?ecia/aiii c?inoaiiy eiioeaio?aoei? O3 a e?iai
iiaeaeuo?oueny iiaieueii i aeinyaa? ii?iaeueiiai iieacieea oieueee /a?ac
3-4 oeaeii iiney anoaiiaeaiiy iaiaoiaeiiai ?iaiy oe?ieneiaii? aeey
iiaii? eiiiainaoei? aiiioe?aico. [O.Oaiaao ic niiaaao., 1988;
U.M.Kaplan,1984].

Iiaieueiee aiii?e/iee iiaeai? aaeaeaaoiiai aeicoaaiiy oe?ai?aeieo
i?aia?aoia iaoiiaeth? aeiaai no?iee (a?ae 2,5 i?nyoe?a aei ?ieo)
?aaaieioaoei? oai?eo [O.Oaiaao ic niiaaao., 1988; I.O.Noa?eiaa, 1991;
R.Hebrmann, 1988].

I?eeiath/e aei oaaae iniaeeainoi iaoaaieicio aeciaaiiiai O4 ia ii/aoeo
eieoaaiiy aiiioe?aico, aoea ai?iaaaeaeaia iaoiaeeea iioaineaii? caiicii?
oa?aii? L-T4, yea aeicaiey? c a?aooaaiiyi nooiaith oe?ai?aeii?
iaaeinoaoiinoi oa aaae oiea oai?iai ia i?ioyci 3-7 aeiia eieaiaeoaaoe
aeaoioeeo oe?ai?aeieo ai?iiiia a i?aaiicii, iicey oeueiai ia?aoiaeeoe ia
iiaeo?eioth/i aeice [I.I. Aieaoeueea, 1994, 1996]. I?e
caaeiaieueiie ia?aiineiinoi L-O4 oaea oa?aiaaoe/ia oaeoeea aeicaiey?
cia/ii nei?ioeoe ia?iiae eiiiainaoei? aiiioe?aico.

Iaeiae, a ?yaei aeiaaeeia oaeiae aeieea? iaiaoiaeiinoue a iioeiicaoei?
ii/aoeiaiai ia?iiaeo oa?aii? aiiioe?aico L-O4 (ia?aae anueai o eioiio
oai?eo c oyaeeith oi?iith oe?ai?aeii? iaaeinoaoiinoi oa ae?aaeaiei
ii?ooaiiyi ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie).

I?eeiath/e aei oaaae oie oaeo, ui aeecaaeaioaoeiy aei caiinii? oa?aii?
aiiioe?aico /anoioa oa?aeoa?eco?oueny na?oeaaeooyi, iineeaiiyi aai
c’yaeaiiyi aieth a aeieyioei na?oey, aeieea? iioa?an aieueo iiaeeaeaii
aea/eoe oa?aeoa? aiaeiiaeaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii?
nenoaie i?e aeei?enoaiii iaoiaeeee iioaineaii? caiinii? oa?aii?
aiiioe?aico L-T4 ia i?ioyci 4-5 oeaeiia aiae ii/aoeo eieoaaiiy.

Aiaeiii, ui aaaeeeao ?ieue a iaoaiicii iiieaeaii? oiea?aioiinoi oai?eo
ia aiiioe?aic aei caiinii? oa?aii? oe?ai?aeieie ai?iiiaie aiaeia?athoue
iiaeaeuaiiy /ooeeainoi oeaiei aei eaoaoieaiiiia, caieueoaiiy iio?aae
iiiea?aea a eenii oa iiaeeaieo ?a/iaeiao, a oaeiae i?enei?aiee o?ainii?o
eaeueoeith a eeioeie [I.O.Noa?eiaa, 1989; I.Klein et al., 1984;
C.T.Sawin, 1985].

A?aoiaoth/e, ui i?aia?aoe a?oie aioaaiiinoia eaeueoeith ia oieueee
i?eaiaeyoue aei ni?eyoeeai? ciiie niiaaiaeiioaiiy iiiia eaeueoeith oa
eaeith a iiiea?aei, aea oaeiae iathoue caaaeueio ia?eoa?e/io
aaciaeieaooth/o aeith, a oiio /enei ?icoe?ththoue aiioeaai noaeeie oa
caieueoothoue ei?iia?iee e?iaiiaia [C.TH.Ia?oeaai/, 1990; E.O.Iaea ic
niiaaao., 1994; I.E.Oa?a?aa, 1995], iiaeia i/?eoaaoe, ui ?o i?ecia/aiiy
a eiiieaeni c L-T4, aoaea ni?eyoe iieiioaiith aaeaioaoei? aei caiinii?
oa?aii? oai?eo ia aiiioe?aic. I?aoeue ii aea/aiith aoaeoeaiinoi
aeei?enoaiiy aioaaiiinoia eaeueoeith noiinii c L-T4 o oai?eo ia
aiiioe?aic iaie ia ciaeaeaii.

Oaeei /eiii, ni?yiiaaiinoue aeaiiai aeineiaeaeaiiy aecia/a?oueny
iaiaoiaeiinoth iiaeeaeaiiai aea/aiiy ooieoeiiiaeueiiai noaio
na?oeaai-noaeeiii? nenoaie o oai?eo ia aiiioe?aic i?e aeei?enoaiii
iaoiaeeee oaeaeei? ii?iaeicaoei? oe?ai?aeieo ai?iiiia a i?aaiicii ca
aeiiiiiaith L-O4, a oaeiae aiaenooiinoth ?ic?iaie oeyoia iiaeaeuaiiy
oiea?aioiinoi aei iioaineaii? oa?aii? L-T4 ia ii/aoeo eieoaaiiy
aiiioe?aico.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeine?ae-aeaiiy
aeeiiaii ca?aeii ieaio iaoeiai-aeine?aeieoeueei? ?iaioe Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a oa Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo oa?iaeioa?ai?? aiaeie?eiieo
caoai?thaaiue, i.Oa?eiaa.

Iaoa aeineiaeaeaiiy. Ioe?iea aieeao iioaineaii? caiinii? oa?aii?
L-oe?ie-neiii noiinii c aioaaiiinoii eaeueoeith (ei?aeaoaiii) ia
ooieoeiiiaeueiee noai na?oeaai-noaeeiii? nenoaie o oai?eo ia aiiioe?aic.

Caaea/i aeineiaeaeaiiy:

1. Aea/eoe iniaeeainoi ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii?
nenoaie o oai?eo ia aiiioe?aic a caeaaeiinoi aiae nooiaiy oe?ai?aeii?
iaaeinoioiinoi oa oa?aeoa?o o?aaeaiiy ueoiaeaeii? caeice.

2. Aeineiaeeoe aeeiaiieo ?aa?ani? aiiioe?aico c o?aooaaiiyi
ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie ia ii/aoeo (ia
i?ioyc? iaeiiai i?nyoey) iioaineaii? caiinii? oa?aii? L-T4.

3. Aea/eoe aeeiaiieo ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie
a i?ioeani iioei?ciaaiiai canoinoaaiiy L-T4 noiinii c aioaaiiinoii
eaeueoeith (ei?aeaoaiii) ia ii/aoeo caiinii? oa?aii? aiiioe?aico.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa ia i?aenoaa? eiiieaeno ?ino?oiaioaeuei?o iaoiae?a ianoaaeaiiy o
oai?eo ia aiiioe?aic i?iaaaeaii ii??aiyeueio ioe?ieo ooieoe?iiaeueiiai
noaio na?oeaai-noaeeiii? nenoaie a caeaaeiino? a?ae oa?aeoa?o o?aaeaiiy
ueoiaeaeii? caeice.

Iaoeiai iaa?oioiaaii aeioe?euei?noue aeeth/aiiy aei eiiieaeno
ianoaaeaiiy iieaciee?a aaiiaeeiai?ee oa oaciai? no?oeoo?e nenoiee e?aiai
oeoii/ea na?oey i?e ?ioaineai?e cai?ni?e oa?ai?? a?iioe?aico L-O4.

Aeyaeaii, ui iioaineaia caiinia oa?aiiy L-T4 ia oieueee iieiioo?
caaaeueiee noai oai?eo ia aiiioe?aic oa i?eaiaeeoue ?o aei
aooe?ai?aeiiai noaio, aea e a cia/iie ii?i ii?iaeico? oeaio?aeueio oa
aioo?ioiueina?oeaao aaiiaeeiaiieo aaea /a?ac 2-3 oeaeii, a iieacieee
o?iiiea?ae?ia?ao?? — a na?aaeiueiio /a?ac iaeei i?nyoeue aiae ii/aoeo
eieoaaiiy.

Aia?oa canoiniaaii niin?a iioei?caoe?? ?ioaineaii? cai?nii? oa?ai?? L-O4
ia ii/aoeo e?eoaaiiy; anoaiiaeaii, ui aeiaeaoeiaa i?ecia/aiiy
aioaaii?noa eaeueoe?th (ei?aeaoaia) ni?ey? nei?i/aiith no?ieia
aiaeiiaeaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie o oai?eo
ia a?iioe?aic.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iieacaia aoaeoeaiinoue
i?iaaaeaiiy o oai?eo ia aiiioe?aic eiiaiiiaaii? oa?aii?, yea aeeth/a?
canoinoaaiiy L-O4 a iioaineaiiio ?aaeeii oa aioaaiiinoa eaeueoeith
(ei?aeaoaia). I?ecia/aiiy aioaaiiinoa eaeueoeith (ei?aeaoaia) ia ii/aoeo
caiinii? oa?aii? aiiioe?aico aeicaieeoue nei?ioeoe no?ie ?aaaieioaoei?
oai?eo oa iieiioeoe oiea?aioiinoue aei L-T4.

Iieacaia aeioeieueiinoue aeineiaeaeaiiy o oai?eo ia aiiioe?aic
iieacieeia aaiiaeeiaiiee oa nei?i/oaaeueii? caeaoiinoi iiiea?aea ia
ii/aoeo caiinii? oa?aii?, ui aeicaieeoue aecia/eoe no?iee eieaiaeaoei?
aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii oa ioeiithaaoe
aaeaeaaoiinoue i?iaaaeaiiy caiinii? oa?aii?.

?acoeueoaoe iaoeiaeo aeineiaeaeaiue oi?iaaaeaeaii: a eeiiioei oa
eiinoeueoaoeaiie iieieeiiioei Oe?a?inueeiai iaoeiai-aeineiaeiiai
?inoeoooo oa?iaeioa?aii? aiaeie?eiieo caoai?thaaiue, 27-e oa iaeaniie
eeiii/ieo eiea?iyo i.Oa?eiaa, iieieeiiioei N 3 i.Oa?eiaa, iaaenai/anoeii
N 12 i.Oa?eiaa, a oaeiae aeeeaaeathoueny ia oeeeeao iineyaeeieiiiiai
iaa/aiiy eaoaae?ith aiaeie?eiieiai? Oa?eianueeiai iinoeoooo
oaeineiiaeaiiy eiea?ia.

Iniiaii iieiaeaiiy aeena?oaoei?, ui aeiinyoueny ia caoeno:

1. O oai?eo ia aiiioe?aic ia? iinoea caeaaeiinoue iieacieeia
aaiiaeeiaiiee oa oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey ia
o?eueee aiae nooiaiy oe?ai?aeii? iaaeinoaoiinoi, aea e oa?aeoa?o
o?aaeaiiy ueoiaeaeii? caeice.

2. Canoinoaaiiy L-T4 o oai?eo ia aiiioe?aic o aeicoaaiii, ui ia?aaeaa/a?
eieaiaeaoeith aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii ia i?ioyci 3-7
aeiia, i?eaiaeeoue aei ii?iaeicaoei? ooieoeiiiaeueiiai noaio
na?oeaai-noaeeiii? nenoaie a na?aaeiueiio ia i?ioyci iaeiiai iinyoey
iacaeaaeii a?ae oyaeeino? caoai?thaaiiy oa oa?aeoa?o o?aaeaiiy
ueoiaeaeii? caeice.

3. Aeeth/aiiy a eiiieaenia eieoaaiiy oai?eo ia aiiioe?aic aioaaiiinoa
eaeueoeith (ei?aeaoaia) aea? aieueo ae?aciee iiceoeaiee aoaeo ia
a?aeiiaeaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie a
ii??aiyii? c iiiioa?ai??th L-O4.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii iniaenoi ?ic?iaeaia i?ia?aia
aeineiaeaeaiiy, i?iaiaeeeinue eieoaaiiy i niinoa?aaeaiiy ca aniia
ianeiaeoaaieie oai?eie, naiinoieii aeeiioaaeinue aeineiaeaeaiiy
na?oeaai-noaeeiii? nenoaie, c?iaeaii aiaeic ?acoeueoaoia eeiii/iiai,
ooieoeiiiaeueiiai, aiioiii/iiai, iioii-eiai/iiai i ai?iiiaeueiiai
ianoaaeaiiy. Aaoi?ii iniaenoi noi?ioeueiaaii ani iieiaeaiiy oa aeniiaee
aeena?oaoei?. Aaoi?o iaeaaeeoue aieiaia ?ieue o i?aeaioiaoe? io?eiaieo
aeaieo aei an?o iaoeiaeo ioae?eaoe?e.

Ai?iaaoeiy ?acoeueoao?a aeena?oaoe??. Iniiaii iieiaeaiiy aeena?oaoei?
iaaiai?aii ia eeiii/iie eiioa?aioei? Oe?a?inueeiai IAeI oa?iaeioa?aii?
aiaeie?eiieo caoai?thaaiue niieueii c eaoaae?ith aiaeie?eiieiai?
Oa?eianueeiai iinoeoooo oaeineiiaeaiiy eiea?ia (1996). Iaoa?iaee
aeena?oaoei? aeiiiaiaeaeenue ia iaoeiaie eiioa?aioei?, i?enay/aiie
25-eiooth iiai? eeiiiee Oe?a?inueeiai IAeI oa?iaeioa?aii? aiaeie?eiieo
caoai?thaaiue (1993), caniaeaiiyo Oa?eianueeiai iaoeiaiai iaaee/iiai
oiaa?enoaa ea?aeiieiaia (1993, 1996) oa aiaeie?eiieiaia (1996),
can?aeaii? eaoaae?e aiaeie?eiieia?? Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i. I.I.Aiaiiieueoey (Ee?a, 1998).

Ioaeieaoei?. Ca iaoa??aeaie aeena?oaoei? iioaeieiaaii 12 iaoeiaeo ?iaio,
c yeeo /ioe?e noaoo? a iaoeiaeo oaoiaeo aeo?iaeao, ui caoaa?aeaeai? AAE
Oe?a?ie, o?e noaoo? o ca??ieeao iaoeiaeo i?aoeue, iaeei ?ioi?iaoe?eiee
eeno oa /ioe?e oace.

Ianya i no?oeoo?a aeena?oaoe??. Aeena?oaoeiy iaae?oeiaaia ia 154
noi?iieao iaoeiiieno i neeaaea?oueny ic anooio, iaeyaeo eioa?aoo?e,
iaoa?iaeia i iaoiaeia aeineiaeaeaiiy, 3 aeaa aeanieo aeineiaeaeaiue,
caeii/aiiy, aeniiaeia oa i?aeoe/ieo ?aeiiaiaeaoeie. Cienie eioa?aoo?e
aeeth/a? 204 aeaea?aea aio/eciyieo i ca?oaiaeieo aaoi?ia. ?iaioa
iethno?iaaia 10 ?enoieaie oa 25 oaaeeoeyie.

CIINO ?IAIOE

Eeiii/ia oa?aeoa?enoeea ianeiaeoaaieo. Ia’?eoii aeineiaeaeaiiy aoee 107
oai?eo ia ia?aeiiee aiiioe?aic, ianoaaeaiiy yeeo i?iaiaeeeinue a
eeiiioei Oe?a?inueeiai iaoeiai-aeineiaeiiai iinoeoooo oa?iaeioa?aii?
aiaeie?eiieo caoai?thaaiue.

O ianoaaeaieo ia?aaaaeaa a?e a?ae 41 aei 50 ?ie?a, a ni?aa?aeiioaiiy
/ieia?e?a oa ae?iie neeaaeaei 1:4. O ia?aaaaeii? aieueoinoi oai?eo (40
/ie. — 37,4%) o?eaaeinoue caoai?thaaiiy aoea aiae 3-o aei 9-oe ?ieia. O
32 iaoei?ioia (29,9%) aeyaeaii niiioaiiee aiiioe?aic (1 iiaea?oia), o 23
(21,5%) — aiiioe?aic ia oiii aooiiioiiiai oe?ai?oeaeo (2 iiaea?oia).
Iineyiia?aoeieiee aiiioe?aic aoa o 52, ic ieo o 29 (27,1%) aiiioe?aic
aeiee iiney oi?o?ai/iiai eieoaaiiy aeeoociiai oiene/iiai ciaa (3
iiaea?oia), o 23 (21,5%) — aooiiioiiiai oe?ai?aeeoo (4 iiaea?oia).

Eaaea oi?ia aiiioe?aico aeyaeaia o 8 iaoei?ioia (7,5%), aiiioe?aic
na?aaeiuei? oyaeeinoi — o 60 (56,1%), oyaeea oi?ia — o 39 (36,4%).

O 26 inia (24,3%) noiooiiie caoai?thaaiiyie aoea ?oai?/ia oai?iaa na?oey
(ION), o 39 oai?eo (36,4%) — a?oa?iaeueia aiia?oaiciy.

Aoaeoeaiinoue ii/aoeiai? caiinii? oa?aii? aiiioe?aico iiaeeaiaeoaeueii
aecia/aieie aeicaie L-T4 aea/aii o 45 oai?eo, yei neeaee eiio?ieueio
a?oio. O 27 inia aeyaeaii aiiioe?aic na?aaeiuei? oyaeeinoi, o 18 —
oyaeea oi?ia.

Aeey i?iaaaeaiiy ioeiiee ?icieo iaoiaeia caiinii? oa?aii? i?e
aiiioe?aici aoei ianoaaeaii 40 oai?eo aiiioe?aicii, yei aaeeaaee L-T4 ii
o?aaeeoeieiie iaoiaeeoei (iiaieueia caieueoaiiy aeice).

Ooieoeiiiaeueiee noai na?oeaai-noaeeiii? nenoaie aea/aii o 60 oai?eo
aiiioe?aicii na?aaeiuei? oyaeeinoi i 39 inia ic oyaeeith oi?iith
caoai?thaaiiy.

Aeineiaeaeaii aoaeoeaiinoue canoinoaaiiy aioaaiiinoa eaeueoeith
ei?aeaoaia a ii?aeiaiii ic L-T4 ia ii/aoeo caiinii? oa?aii?, yea
i?iaiaeeeanue a iiaeeaiaeoaeueiiio ?aaeeii i ia?aaeaa/aea onoiaiiy
aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii i?ioyaii 3-7 aeiia.

Ia?oo eiio?ieueio a?oio (50 inia) neeaee iaoei?ioe, eio?i io?eioaaee
oieueee L-T4 a iiaeeaiaeoaeueiie aeici. Eaaea oi?ia aiiioe?aico aeyaeaia
o 4 oai?eo, aiiioe?aic na?aaeiuei? oyaeeinoi — o 28 inia, oyaeea oi?ia —
o 18.

Ae?oaa ianoaaeaia a?oia neeaaeaea 57 inia, yei ?acii ic
iiaeeaiaeoaeueiith aeicith L-T4 aaeeaaee aioaaiiino eaeueoeith ei?aeaoai
(«Iieueoa», 1 oaaeaoea iinoeoue 10 ia) a aeici 20-30 ia a aeaiue
i?ioyaii 21-28 aeiia. Eaaea oi?ia aeyaeaia o 4 oai?eo, aiiioe?aic
na?aaeiuei? oyaeeinoi — o 32 inia, oyaeea oi?ia o 21 iaoei?ioa.

Ca a?eii, o?eaae?noth, aaaee?noth, oa?aeoa?ii o?aaeaiiy ueoiaeaeii?
caeice oa iayai?noth noiooiuei? iaoieia?? a?oie aoee noaoenoe/ii
iaeii??aei?.

Aeey ii?iaiyiiy iaea?aeaieo ?acoeueoaoia aoea ianeiaeoaaia a?oia
i?aeoe/ii caei?iaeo ethaeae (25 inia).

Iaeaieueo /anoeie nea?aaie oai?eo aoei aiae/oooy caaaeueii? neaaeinoi
(92,5%), ia?ceyeoaaoinoue (63,6%), niieeainoue (82%), iaa?ye iaee//y i
eiioeiaie (73,8%), nooinoue oei?e (71,9%), iaaeeeoeiaa aaaa oiea
(52,3%), caii?e (47,7%). Nea?ae ia aieue a aeieyioei na?oey i?aae’yaeyee
64 (59,8%) oai?eo ia aiiioe?aic. O 62 (57,9%) iaoei?ioia aeyaeyeanue
a?aaeeea?aeiy, o 8 (7,5%) — oaoiea?aeiy.

Aiaeic eeiii/ii? neiioiiaoeee ?icieo aa?iaioia aiiioe?aico iieacaa, ui
iaeaieueo ae?aaeai? eeiii/i? i?iyae niinoa?iaaeenue i?e niiioaiiiio
aiiioe?aici oa aiiioe?aici, ui aeiee iiney iia?aoei? c i?eaiaeo
aeeoociiai oiene/iiai ciaa.

Iaoa?iaee oa iaoiaee aeineiaeaeaiiy. ?iaaiue oe?io?iiiio,
o?eeiaeoe?iiiio i oe?ieneio aecia/aee ?aaeiiiioiieiai/iei iaoiaeii c
aeei?enoaiiyi noaiaea?oieo oano-iaai?ia: RIA-mat TSH (Iiia//eia),
PIO-T3-IA (Aiei?onue), PIO-T4-IA (Aiei?onue).

Aioeoiea aei oe?aiaeiaoeiio i iie?iniiaeueiiai aioeaaio aeine?aeaeaii
iio-iioa?iaioiei iaoiaeii.

Eiiiaeiee iaiii aea/aee oeyoii aecia/aiiy caaaeueiiai oieanoa?eio (ON) a
ne?iaaooei e?iai iaoiaeii Ieueea, aaoa-eiiii?ioa?aee (A-EI) — ii
Ao?ooaeio i Naiath.

Aeaeo?iea?ae?ia?ao?y i?iaiaeeeanue ca caaaeueiii?eeiyoith iaoiaeeeith.

Aeey aea/aiiy iieacieeia oeaio?aeueii? aaiiaeeiaiiee canoiniaoaaee
oao?aiiey?io a?oaeio ?aia?aoith ca iaoiaeii W.G.Kubicek a iiaeeoieaoei?
TH.O.Iooea?y. C oei?th iaoith aeei?enoiaoaaee ?aia?ao ?IA-2-02 c
?aaino?aoi?ii 6-NEK. Aea/aeenue oaei iieacieee: oaea?iee ia’?i (OI, ie),
oaeeeiiee ia’?i e?iai (OIE, e/oa), oaea?iee iiaeaen (OI, ie/i2),
na?oeaaee iiaeaen (NI, e/oa/i2), caaaeueiee ia?eoa?ieiee noaeeiiee iii?
(CINI, aeei·n·ni-5), na?aaeiie aaiiaeeiaii/iee oene (NAAeO, ii ?o.no.).

Aeey aeineiaeaeaiiy oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey
i?iaiaeeeanue o?iiiea?aeiia?aoiy. Oaciaee aiaeic caeienithaaee ca
iaoiaeii A.E.Ea?iiaia. Aea/aee ia?aiao?e: oaca aneio?iiiiai oa
iciiao?e/iiai nei?i/aiiy (AN oa IC, n), ia?iiae iai?oae (O, n), ia?iiae
aeaiaiiy (A, n), iaoaii/ia i caaaeueia nenoiea (Sm oa So, c).
?ic?aoiaoaaeenue iiaeoaciai iieacieee: iaoaii/iee eiaoioei?io (IE),
aioo?ioiueinenoiei/iee iieaciee (ANI, %), iiaeaen iai?oae iiiea?aea
(III, %).

Aeey aea/aiiy ii?oieiai/ieo no?oeoo? i aioo?ioiueina?oeaai?
aaiiaeeiaiiee canoiniaoaaee iaoiae aoiea?aeiia?aoi? (a A- oa I- ?aaeeii)
ia aia?aoi «Aloka-SSD-280» (ssiiiiy) c aeei?enoaiiyi aeao/eea ic
/anoioith 3 iAoe i eooii ?icai?oee 80 a?aaeonia ii caaaeueiii?eeiyoie
iaoiaeeoei. Aea/aeenue oaei iieacieee: eiioeaaee nenoiei/iee i eiioeaaee
aeianoie?/iee ia’?i (ENI i EAeI), o?aeoeiy aeeeaeo (OA, %), nooiiiue
oei?i/aiiy ia?aaeiuei-caaeiueiai ?icii?o eiaiai oeoii/ea (NOEO, %),
oaeaeeinoue oei?i/aiiy oee?eoeyoi?ieo aieieii iiiea?aea (OOOeA, eiei/n).

Iienaii iaoiaee aeineiaeaeaiiy canoiniaoaaeeny o oai?eo aei i?ecia/aiiy
eieoaaiiy, ia 14-21 aeaiue i 28-35 aeaiue aiae ii/aoeo oa?aii?.

Aeey ?ic?aooieo iiaeeaiaeoaeueieo aeic L-T4 aeei?enoiaoaaeenue oi?ioee,
yei aeicaieyee aecia/eoe ii/aoeiao oa iiaeo?eioth/o aeice (Aei i Aei)
i?aia?aoo c o?aooaaiiyi aacaeueii? eiioeaio?aoei? O4 a e?iai oa aaae
oiea oai?iai:

Aei = 10 iea·I – 100·L

Aei = 4 iea·I – 50·L,

aea I — aaaa oiea oai?iai (ea), L — aeiaiacii eiioeaio?aoei? O4 a
ne?iaaooei e?iai:

L = 1 i?e Ni F 10 iiieue/e,

L = 2 i?e 10 < Co F 20 iiieue/e, L = 3 i?e 20 < Co F 30 iiieue/e, L = 4 i?e 30 < No F 40 iiieue/e, L = 5 i?e 40 < Co F 50 iiieue/e, L = 6 i?e 50 < Co F 60 iiieue/e, aea Ni - aacaeueia eiioeaio?aoeiy O4 a e?iai [I.I.A?eaoeueea, 1994, 1996]. Na?aaeii aeice Aei i Aei i?e eaaeie oi?ii aiiioe?aico noaiiaeee aiaeiiaiaeii aeecueei 250 oa 90 iea, i?e na?aaeiie oyaeeinoi - 425 oa 150 iea, i?e oyaeeie - 740 oa 250 iea. Iiaeo?eioth/o aeico ani oai?i aaeeaaee a?aioei ca aiaeeio aei ?aei. C ia?oiai aeiy eieoaaiiy aei oei?? eieueeinoi i?aia?aoo i?eaaaeyee /anoeio Aei ca iaeei /e aeaa ?ace oae, uia iaeii?aciaa aaaaeaiiy L-T4 ia ia?aaeuoaaei 300 iea. A caeaaeiinoi aiae oyaeeinoi aiiioe?aico, aieo oai?eo oa iayaiinoi noiooiuei? iaoieiai?, aaeeaaiiy Aei ?iciiaeieyee ia 3-7 aeiia. Noaoenoe/iee aiaeic ?acoeueoaoia aeineiaeaeaiiy aeeiioaaee ca aeiiiiiaith iaeaoa i?ia?ai "STATGRAPHICS", yeee aeeth/a? aecia/aiiy caaaeueieo oa?aeoa?enoee ?yaeia, ei?aeyoeieiee aiaeic, ioeiieo aeinoiai?iinoi ?icieoeue ic canoinoaaiiyi e?eoa?ith No'thaeaioa. ?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. I?e aiaeici ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie aeyaeaii aieueo cia/ii ciiie iieacieeia oeaio?aeueii? oa aioo?ioiueina?oeaai? aaiiaeeiai?ee, oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey o oai?eo ic oyaeeith oi?iith aiiioe?aico a noaii aeaeiiiainaoei?. O oai?eo ic na?aaeiueith oa oyaeeith oi?iith oe?ai?aeii? iaaeinoaoiinoi aei i?ecia/aiiy caiinii? oa?aii? niinoa?iaaeanue aeinoiai?ia (?0,05) ?icieoey iieacieeia OI, OIE, OI, NI, CINI, EAeI, ENI, IC, ANI, III. Aieueo ae?aaeaii ciiie ia?aiao?ia ea?aeii- i aaiiaeeiaiiee niinoa??aaeenue o oai?eo ic niiioaiiei aiiioe?aicii. O oai?eo ?c niiioaiiei a?iioe?aicii a ii??aiyii? c i?neaiia?aoe?eiei a?iioe?aicii, yeee aeiee i?ney o??o?a?/iiai e?eoaaiiy aeeoociiai oiene/iiai ciaa a?aei?/aeanue aeinoia??ia (?0,05) ??cieoey iieaciee?a OO, XOK, C?, ?C, T, MK, ANI oa ?II. Aeyaeaii ei?aeyoeieii ca'ycee iiae eiioeaio?aoei?th O4 a ne?iaaooei e?iai i iieacieeaie OI, NI, CINI aiaeiiaiaeii: r = + 0,654, r = + 0,673, r = - 0,545, p < 0,05, ui iiaea aooe aeei?enoaii aeey ioeiiee aaeaeaaoiinoi i?iaaaeaiiy ?ioaineaii? caiinii? oa?aii? i?e aiiioe?aici. I?ae aieeaii iioaineaii? caiinii? oa?aii? L-T4 iieiioaiiy naiiii/oooy oai?eo (ciaioaiiy iaa?yeia, ia?ceyeoaaoinoi) ie niinoa?iaaee aaea iiney iaeiiai-aeaio aeiia aaeeaaiiy iiaeeaiaeoaeueii aecia/aieo aeic L-T4. *a?ac 2-3 oeaeii i?aeoe/ii cianii cieeaee oaei i?iyae aiiioe?aico, ye ia?ceyeoaaoinoue, iaa?yee, niieeainoue. Cia/ii ciaioeeenue caaaeueia neaaeinoue, aieue a na?oei, a?aaeeea?aeiy, aeeniaioe/i? i?iyae, caii?e. Iaeiae, ainii oai?eo ia aiiioe?aic (2 iniae ic na?aaeiueith i 6 - ic oyaeeith oi?iith) a?e yeeo aoa a?eueo 45 ?ieia ic noiooiueith ION aiaeii/aee aieue a na?oei. A?oa?iaeueia aiia?oaiciy aei oeueiai /ano caa?iaaeanue o 10 inia (4 oai?eo ic na?aaeiueith oyaeeinoth i 6 - ic oyaeeith oi?iith aiiioe?aico). A na?aaeiueiio /a?ac iinyoeue aiae ii/aoeo caiinii? oa?aii? ie niinoa?iaaee cieeiaiiy aieueoinoi eeiii/ieo neiioiiia aiiioe?aico. Iiae aei?th i?iaaaeaii? caiinii? oa?aii? c canoinoaaiiyi iiaeeaiaeoaeiciaaieo aeic L-T4 ia 14-21-e aeaiue aiae ii/aoeo eieoaaiiy iiaeaeueany ?iaaiue O4 a ne?iaaooei e?iai (ic 29,224,92, iiieue/e aei 122,516,54 iiieue/e, ?0,05), O3 – (ic 0,630,07 iiieue/e aei 1,300,07 iiieue/e, ?0,05). Eiioeaio?aoeiy OOA cieceeanue (aiae 23,822,63 iII/e aei 2,090,40 iII/e, ?0,05) i ia aiae?iciyeanue aiae ii?ie. Ii?iaeicaoeiy oe?ai?aeiiai noaoono ii /ano niiaiaaeaea ic cieeiaiiyi iaoiaiiiiii/ieo neiioiiia aiiioe?aico: iaa?yeia, ia?ceyeoaaoinoi. Aei ae?oaiai-o?aoueiai oeaeiy aiae ii/aoeo eieoaaiiy aiaeaoeiny cieaeaiiy ?iaiy ON (ic 8,230,42 iiieue/e aei 5,810,21 iiieue/e, ?0,05), A-EI (ic 85,45,8 iae. aei 58,24,1 iae., ?0,05). Iniiaieie oaiaeaioeiyie ?icaeoeo ii?ooaiue ?iaioe na?oey i ciiie aaiiaeeiai?ee o oai?eo ia aiiioe?aic aei i?ecia/aiiy iioaineaii? caiinii? oa?aii? aoee aeeeaoaoeiy ii?iaeieie eiaiai oeoii/ea na?oey, cieaeaiiy nei?i/oaaeueii? ooieoei? iiiea?aea, ui i?iyaeyeinue o caieueoaiii EAeI, ENI i CINI, aeaeiaaeaiii IC, Sm i So, ciaioaiii OI, OIE, NI, OI, OA i OOOeA. Oei ciiie aiaeiiaiaeaee aiiieiiaoe/iiio oeio e?iaiiaiao i oaciaiio neiae?iio aiiiaeeiaii? iiiea?aea. Ia 14-21-e aeaiue iioaineaii? caiinii? oa?aii? aiaeaoeiny cia/ia iieiioaiiy iieacieeia oeaio?aeueii? oa aioo?ioiueina?oeaai? aaiiaeeiaiiee. Iieacieee oaciai? no?oeoo?e nenoiee aei oeueiai ia?iiaeo ciiithaaeenue iacia/ii. *a?ac iinyoeue aiae ii/aoeo eieoaaiiy iieacieee aaiiaeeiaiiee ii?iaeicoaaeenue, a oaeiae aiaeaoeany ii?iaeicaoeiy aieueoinoi iieacieeia oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea. Aiaeic oe?ai?aeiiai noaoono, iieacieee aee?iaiai iaiiio, aaiiaeeiaiiee i nei?i/oaaeueii? ooieoei? na?oey o 40 oai?eo ia aiiioe?aic, yei o?eaaeee /an aaeeaaee L-T4 ii o?aaeeoeieiie iaoiaeeoei (iiaieueia caieueoaiiy aeice), iieacaa aiaenooiinoue iiaii? eiiiainaoei? oe?ai?aeii? iaaeinoaoiinoi, iayaiinoue aeeeaoaoei? ii?iaeieie eiaiai oeoii/ea, aiiie?iaoe/iiai oeio e?iaiiaiao i oaciaiai neiae?iio aiiiaeeiaii? iiiea?aea. Iaoiaeeea oaeaeeiai onoiaiiy aeaoioeeoo oe?ai?aeieo ai?iiiia a ii/aoeiaiio ia?iiaei caiinii? oa?aii?, a iniiaiiio, ni?eeiaeanue oai?eie aeia?a. Iaeiae, o iaoei?ioia a?e yeeo aoa a?eueo 45 ?ieia ic na?aaeiueith oa oyaeeith oi?iith aiiioe?aico, noiooiueith ION oa a?oa?iaeueiith aiia?oaici?th ia ii/aoeo eieoaaiiy aeioeieueii ii?yae ic L-T4 canoiniaoaaoe i?aia?aoe, yei iie?ioothoue aaeaioaoeith na?oeaai-noaeeiii? nenoaie aei aeciaaiieo oe?ai?aeieo ai?iiiia. A?aoiaoth/e, ui aioaaiiinoe eaeueoeith iathoue aaciaeoeaii, ea?aeiii?ioae-oi?ii, aioeaa?aaaoeieii aeanoeainoi, ni?yiiaaii ia noaaieicaoeith aaiiaeeiaiiee, iieiioaiiy ei?iia?iiai e?iaiiaiao, ia?eoa?e/ii? iie?ioee?eoeyoei?, aeianoiei/-ii? ooieoei? iiiea?aea i cieaeaiiy iio?aae a eenii, iiaeia i/ieoaaoe, ui ?o canoinoaaiiy a eiiieaeni ic oe?ai?aeieie ai?iiiaie aoaea ni?eyoe iie?ioaiith ooieoei? na?oeaai-noaeeiii? nenoaie oai?eo ia aiiioe?aic ia ii/aoeo caiinii? oa?aii?. Aei ii/aoeo oa?aii? aieue a aeieyioei na?oey eieth/iai oa?aeoa?o, yeee ia iiaiinoth eoi??oaaany aioeaiaiiaeueieie i?aia?aoaie, a a?oii c iiiioa?aii?th L-T4 niinoa?iaaany o 31 (62%) i o 33 inia (57,9%) - c eiiieaeniei eieoaaiiyi. *a?ac iaeei-aeaa aeii aiae ii/aoeo eieoaaiiy naiiii/oooy oai?eo iie?auaei a iaio a?oiao. Ia i?ioyci ia?oiai oeaeiy iiaiinoth cieeee ia?ceyeoaaoinoue, iaa?yee. O 8 iaoei?ioia (16 %) ia?oi? a?oie /a?ac 1-2 oeaeii aiae ii/aoeo eieoaaiiy caa?iaaany eieth/ee aieue a na?oei, o 10 (20 %) - a?oa?iaeueia aiia?oaiciy. O oai?eo ae?oai? a?oie aieue a aeieyioei na?oey cieeaa ia 3-5 aeaiue, iiaeaeuaiee a?oa?iaeueiee oene caa?iaaany o 3 inia (5,3%). *a?ac 2-3 oeaeii naiiii/oooy oai?eo a iaio a?oiao aoei caaeiaieueia. Ia oiii caiinii? oa?aii? ia aeyaeaii ?icieoei a iieacieeao oe?ai?aeiiai noaoono (oaae. 1). Niinoa?iaaeanue oaeaeea ii?iaeicaoeiy iieacieeia aee?iaiai iaiiio o oai?eo, yei iaea?aeoaaee eiiieaenia eieoaaiiy (oaae. 1). Ia 14-21 aeaiue oa?aii? iieacieee oeaio?aeueii? i aioo?ioiueina?oeaai? aaiiaeeiaiiee cia/ii iieiioeeeny (oaae. 2). Aieueo oaeaeea i /ioea iiceoeaia aeeiaiiea niinoa?iaaeanue o iaoei?ioia ic eiiieaeniei eieoaaiiyi. *a?ac iinyoeue aiae ii/aoeo oa?aii? iieacieee aaiiaeeiaiiee a iaio a?oiao aiaeiiaiaeaee aoeiiaoe/iiio oeio e?iaiiaiao. Iieacieee oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea a iaio a?oiao aei 14-21 aeiy oa?aii? ia aiae?iciyeenue iiae niaith i ciiithaaeeny iacia/ii (oaae. 3). O iaoei?ioia ic eiiieaeniith oa?aii?th oaea /a?ac iinyoeue aiae ii/aoeo eieoaaiiy niinoa?iaaeanue iiiioia iiceoeaia aeeiaiiea iieacieeia oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey. Aaciina?aaei? oa?aiaaoe/ia cia/aiiy aioaaiiinoia eaeueoeith iaoiiaeaii ii?iaeicaoei?th aeaeo?ieioieo ii?ooaiue o iiioeeoao i iieiioaiiyi nei?i/oaaeueii? ooieoei? eiaiai oeoii/ea, cieaeaiiyi iio?aae iiiea?aea a eenii ca ?aooiie iie?auaiiy aaiiaeeiaiiee: cieaeaiiy ia?aae- i iineyiaaaioaaeaiiy iiiea?aea, caieueoaiiyi ei?iia?iiai e?iaiiaiao, ciaioaiiyi iai?oae iiiea?aea eiaiai oeoii/ea. ?o aoaeoeaiinoue iiaea aooe ?aaeiciaaia iiae /an aeei?enoaiiy oeeo i?aia?aoia o oai?eo ia aiiioe?aic ia ii/aoeo iioaineaii? caiinii? oa?aii? L-T4, iniaeeai o eioiio oai?eo i?e oyaeeie oi?ii caoai?thaaiiy oa ae?aaeaieo ii?ooaiiyo ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie. AENIIAEE 1. Ii?ooaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie o oai?eo ia aiiioe?aic aei i?ecia/aiiy caiinii? oa?aii? ia? ca'ycie ia o?eueee ic nooiaiai oe?ai?aeii? iaaeinoaoiinoi, aea e oa?aeoa?ii o?aaeaiiy ueoiaeaeii? caeice. 2. A?eueo ae?aaeai? ci?ie iieaciee?a ooieoe?iiaeueiiai noaio na?oeaai-noaeeiii? nenoaie aeyaeaii o oai?eo ia niiioaiiee a?iioe?aic. 3. Iniothoue ei?aeyoeieii ca'ycee iiae ?iaiai oe?ieneio i iieacieeaie oaea?iiai iiaeaeno, na?oeaaiai iiaeaeno i caaaeueiiai ia?eoa?ieiiai noaeeiiiai iii?o, ui iiaea aooe aeei?enoaii aeey ioe?iee aoaeoeaiino? i?iaaaeaiiy ?ioaineaii? cai?nii? oa?ai?? a?iioe?aico L-oe?ieneiii. 5. Ii?iaeicaoeiy aeayeeo iieacieeia oeaio?aeueii? i aioo?ioiueina?oeaai? aaiiaeeiaiiee o oai?eo ia aiiioe?aic a i?ioeani iioaineaii? oa?aii? L-oe?ieneiii aiaeaoaa?oueny oaeaeoa (ia 14-21 aeaiue), a ii??aiyii? c ii?iaeicaoei?th o?eaaeinoi oac na?oeaaiai oeeeeo (ia 28-35 aeaiue). 6. I?ecia/aiiy aioaaiiinoa eaeueoeith (ei?aeaoaia) ia ii/aoeo iioaineaii? caiinii? oa?aii? L-oe?ieneiii i?e na?aaeiie oa oyaeeie oi?iao aiiioe?aico ni?eythoue nei?i/aiith oa?i?i?a ii?iae?caoe?? aaiiaeeiaiiee oa oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey a ii??aiyii? c iiiioa?ai??th L-oe?ieneiii. I?AEOE*II ?AEIIAIAeAOeI? 1. Aeey nei?i/aiiy no?ie?a ?aaa?e?oaoe?? oai?eo ia a?iioe?aic ia ii/aoeo e?eoaaiiy aeioe?eueii i?ecia/aoe L-oe?ienei a aeici, yea ia?aaeaa/a? eieaiaeaoeith aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii ia i?ioyci 3-7 aeiia. 2. Aeey ioeiiee aoaeoeaiinoi caiinii? oa?aii?, yea i?iaiaeeoueny oai?ei ia aiiioe?aic, ii?yae ic aecia/aiiyi aiinoo oe?io?iiiio, oe?ieneio, o?eeiaeoe?iiiio, iieacieeia aee?iaiai iaiiio, aeioeieueii aeineiaeaeoaaoe noai oeaio?aeueii? i aioo?ioiueina?oeaai? aaiiaeeiaiiee, oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey. 3. Aeey nei?i/aiiy no?ie?a ii?iae?caoe?? ooieoe?iiaeueiiai noaio na?oeaai-noaeeiii? nenoaie oa i?aeaeuaiiy aaeaioaoe?? aei ?ioaineaii? cai?nii? oa?ai?? o oai?eo ia a?iioe?aic ?aeiiaiaeo?oueny aeeth/aiiy a eiiieaen e?eoaaiiy aioaaiiinoa eaeueoeith (ei?aeaoaia) a aeici 20-30 ia a aeaiue i?ioyaii 21-28 aeiia. IA?AEIE IOAEIEAOeIE II OAII AeENA?OAOeI? 1. Aaeaoeeay I.I., Ieaeieeiaa N.I., Iaoa?ia A.A., A?ei/aiei O.N., Niiieia TH.I., Aunioeeay A.A. Ia yooaeoeaiinoe caianoeoaeueiie oa?aiee i?e aeiioe?aica// Eiea?nueea ni?aaa. - 1994. - N5. N.74-78. 2. Ieieieeiaa N.I. Canoinoaaiiy ei?aeaoaia noiinii c L-oe?ieneiii ia ii/aoeo eieoaaiiy aiiioe?aico// Eeiii/ia oa?iaoeiy. 1997. - N1. - C.66-69. 3. Aieaoeueea I.I., Ieieieeiaa N.I. Iaoiaeeea canoinoaaiiy ei?aeaoaio noiinii c L-oe?ieneiii ia ii/aoeo eieoaaiiy aiiioe?aico// Eiee. - 1997. - N5 . - N.41-44. 4. Ieaeieeiaa N.I. Aeeyiea aioaaiienoa eaeueoeey ei?aeaoaia ia nie?aoeoaeueioth niiniaiinoue ieiea?aea i?e caianoeoaeueiie oa?aiee aeiioe?aica// Oa?iaeii. - 1998. - N2. - C.62-65. 5. Aaeaoeeay I.I., Aa?iaiiae/ A.I., Iioei A.A., Ieaeieeiaa N.I., Aunioeeay A.A., Niiieia TH.I. Ooieoeeiiaeueiia ninoiyiea na?aea/ii-ninoaeenoie nenoaiu a ia/aeueiii ia?eiaea caianoeoaeueiie oa?aiee aeiioe?aica i?e iioeiece?iaaiiii ?aaeeia i?eaia L-oe?ieneia// Iiaia a i?ioeeaeoeea, aeeaaiinoeea e ea/aiee iniiaiuo caaieaaaiee na?aea/ii-ninoaeenoie nenoaiu: Na. iao/. o?. Oe?aeineiai IEE oa?aiee AII Oe?aeiu. - Oa?ueeia, 1993. - N.32-37. 6. Aaeaoeeay I.I., Ieaeieeiaa N.I., A?ei/aiei O.N., Iaoa?ia A.A., Oeeyaa A.A., Aunioeeay A.A. Aeaa oacu ?aaeoeoeee eeeie/aneie neiioiiaoeee aeiioe?aica a ia/aea caianoeoaeueiie oa?aiee iaoiaeii auno?ie eiiiainaoeee aeaoeoeeoa oe?aieaeiuo ai?iiiia // Iaaeeoeeia: yenia?eiaio, i?aeoeea: Na. iao/. noaoae Oa?ueeianeiai einoeoooa oniaa?oainoaiaaiey a?a/ae. - Oa?ueeia.: I?aii?, 1994. - N.95-97. 7. Niiieia TH.I., Ieaeieeiaa N.I., Eaa?iaa A.A., Aaeaoeeay I.I. Ooieoeeiiaeueiua iaoiaeu enneaaeiaaiey a aeeaaiinoeea ne?uoie na?aea/iie iaaeinoaoi/iinoe o aieueiuo aeiioe?aicii// Iaaeeoeeia: yenia?eiaio, i?aeoeea: Na. iao/. noaoae Oa?ueeianeiai einoeoooa oniaa?oainoaiaaiey a?a/ae. - Oa?ueeia.: I?aii?, 1994. - N.128-130. 8. Aieaoeueea I.I., Iaoa?ia A.A., Ieieieeiaa N.I., A?ei/aiei O.N., Oiey?a A.A. Iaoiaeeea eieoaaiiy aiiioe?aico oe?ieneiii// Iioi?i. eeno: Oe?a?inueeee IAeI oa?iaeioa?aii? aiaeie?eiieo caoai?thaaiue, Oa?eianueeee iinoeooo oaeineiiaeaiiy eiea?ia. - 1993. - 3n. 9. Ieaeieeiaa N.I., Aaeaoeeay I.I. Caianoeoaeueiay oa?aiey aeiioe?aica ia i?eioeeiao oa?iaeieeiaoe/aneiai iiaeoiaea// Oac.aeiee. 2 Ana?inneeneiai nuacaea yiaeie?eiieiaia. - *aeyaeine, 1991. - N.302. 10. Ieaeieeiaa N.I., Aaeaoeeay I.I., Niiieia TH.I., Aunioeeay A.A. Nie?aoeoaeueiay niiniaiinoue ieiea?aea o aieueiuo aeiioe?aicii a i?ioeanna caianoeoaeueiie oa?aiee// Nia?aiaiiua i?iaeaiu eeeie/aneie yiaeie?eiieiaee: Oac. aeiee. i.-i?aeo. eiio. - Oa?ueeia, 1993. - N.43-44. 11. Ieieieeiaa N.I., Aieaoeueea I.I., Aenioeueea I.A. Iioi?iaoeaiinoue iieacieeia oeaio?aeueii? aaiiaeeiaiiee i?e aiiioe?aici// No/anii i?iaeaie aenia?eiaioaeueii? oa eeiii/ii? aiaeie?eiieiai?: Oace aeii. 5 c'?caeo aiaeie?eiieiaia Oe?a?ie. - Iaaii-O?aieianuee, 1994. - N.215. 12. Aaeaoeeay I.I., Ieaeieeiaa N.I. Aeeiaieea oaciaie no?oeoo?u nenoieu eaaiai aeaeoaei/ea na?aeoea a ia/aeueiii ia?eiaea ea/aiey aeiioe?aica L-oe?ieneiii// Aeooaeueiua aii?inu yiaeie?eiieiaee: Oac. aeiee. i.-i?aeo. eiio. - Eaia?iai, 1996. - N.17. AIIOAOe?ss Ieieieeiaa N.I. Aieea iioaineaii? caiinii? oa?aii? L-oe?ieneiii noiinii c aioaaiiinoii eaeueoeith (ei?aeaoaiii) ia ooieoeiiiaeueiee noai na?oeaai-noaeeiii? nenoaie i?e aiiioe?aici. Aeena?oaoeiy ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoeiaeueiinoth 14.01.14 - aiaeie?eiieiaiy, Iinoeooo aiaeie?eiieiai? oa iaiiio ?a/iaei ii. A.I.Eiiina?aiea AII Oe?a?ie, Ee?a, 1998. Ia iniiai eeiiiei-iino?oiaioaeueieo aeineiaeaeaiue aea/aii ooieoeiiiaeueiee noai na?oeaai-noaeeiii? nenoaie o oai?eo ia aiiioe?aic ia ii/aoeo iioaineaii? caiinii? oa?aii? L-oe?ieneiii, yea ia?aaeaa/aea eieaiaeaoeith aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii i?ioyaii 3-7 aeiia. Anoaiiaeaii iniaeeainoi ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie a caeaaeiinoi aiae nooiaith oe?ai?aeii? iaaeinoaoiinoi i oa?aeoa?o o?aaeaiiy ueoiaeaeii? caeice. Aeyaeaii ae?acii ii?ooaiiy oeaio?aeueii? i aioo?ioiueina?oeaai? aaiiaeeiaiiee, oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey i?e oyaeeie oi?ii oe?ai?aeii? iaaeinoaoiinoi, niiioaiiiio aiiioe?aici i iineyiia?aoeieiiio aiiioe?aici iiney aeeoociiai oiene/iiai ciaa. Aeyaeaii iiceoeaiee aieea aioaaiiinoa eaeueoeith (ei?aeaoaia) ia ii/aoeo iioaineaii? caiinii? oa?aii? L-oe?ieneiii ia eeiii/io neiioiiaoeeo oe?ai?aeii? iaaeinoaoiinoi, iieacieee aee?iaiai iaiiio, aaiiaeeiaiieo, nei?i/oaaeueio ooieoeith iiiea?aea. Eeth/iai neiaa: aiiioe?aic, na?oeaai-noaeeiia nenoaia, aaiiaeeiaiiea, oaciaa no?oeoo?a nenoiee eiaiai oeoii/ea na?oey, oe?ienei, ei?aeaoai. AIIIOAOeEss Ieaeieeiaa N.I. Aeeyiea eioaineaiie caianoeoaeueiie oa?aiee L-oe?ieneiii a ni/aoaiee n aioaaiienoii eaeueoeey (ei?aeaoaiii) ia ooieoeeiiaeueiia ninoiyiea na?aea/ii-ninoaeenoie nenoaiu i?e aeiioe?aica. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.14 - yiaeie?eiieiaey, Einoeooo yiaeie?eiieiaee e iaiaia aauanoa ei. A.I.Eiienna?aiei AII Oe?aeiu, Eeaa, 1998. Ia iniiaaiee aeaiiuo eeeieei-eino?oiaioaeueiuo enneaaeiaaiee eco/aii ooieoeeiiaeueiia ninoiyiea na?aea/ii-ninoaeenoie nenoaiu o aieueiuo aeiioe?aicii a ia/aeueiii ia?eiaea eioaineaiie caianoeoaeueiie oa?aiee L-oe?ieneiii, i?aaeoniao?eaathuai eeeaeaeaoeeth aeaoeoeeoa oe?aieaeiuo ai?iiiia a i?aaiecia a oa/aiea 3-7 aeiae. Onoaiiaeaiu iniaaiiinoe ooieoeeiiaeueiiai ninoiyiey na?aea/ii-ninoaeenoie nenoaiu a caaeneiinoe io noaiaie oe?aieaeiie iaaeinoaoi/iinoe e oa?aeoa?a ii?aaeaiey ueoiaeaeiie aeaeacu. Auyaeaiu au?aaeaiiua ia?ooaiey oeaio?aeueiie e aioo?ena?aea/iie aaiiaeeiaieee, oaciaie no?oeoo?u nenoieu eaaiai aeaeoaei/ea i?e oyaeaeie oi?ia oe?aieaeiie iaaeinoaoi/iinoe, niiioaiiii aeiioe?aica e iineaiia?aoeeiiiii aeiioe?aica iinea aeeooociiai oiene/aneiai ciaa. Ii?aaeaeaii iieiaeeoaeueiia aeeyiea aioaaiienoa eaeueoeey (ei?aeaoaia) a ia/aeueiii ia?eiaea eioaineaiie caianoeoaeueiie oa?aiee aeiioe?aica L-oe?ieneiii ia eeeie/aneoth neiioiiaoeeo oe?aieaeiie iaaeinoaoi/iinoe, iieacaoaee aee?iaiai iaiaia, aaiiaeeiaieeo, nie?aoeoaeueioth ooieoeeth ieiea?aea. Eeth/aaua neiaa: aeiioe?aic, na?aea/ii-ninoaeenoay nenoaia, aaiiaeeiaieea, oaciaay no?oeoo?a nenoieu eaaiai aeaeoaei/ea na?aeoea, oe?ienei, ei?aeaoai. SUMMARY Oleinikova S.P. Influence of intense L-thyroxine replacement therapy in combination with the calcium antagonist (cordafen) on functional characteristics of cardiovascular system diseased by hypothyroidism. Thesis for the degree of Candidate of medical science on speciality 14.01.14 - Endocrinology. Institute of Endocrinology and Metabolism name after V.P.Komissarenko (AMS, Ukraine), Kyiv, 1998. Taking into consideration the results of clinical and instrumental research the state of functional characteristics of cardiovascular system of the hypothyroid patients has been studied during the initial period of intense L-thyroxine replacement therapy which liquidates insufficiency of thyroid hormones in organism for 3-7 days. Depending on thyroid insufficiency level and thyroid gland disease natyre the peculiarities of functional characteristics of cardiovascular system have been shown. Strong changes of the central and intracardiac heamodynamics, systolic time intervals of the left heart ventricle diseased by dangerous form of thyroid insufficiency, spontaneous hypothyroidism and post-operational hypothyroidism after hyperthyroidism have been revealed. Positive influence of calcium antagonist (cordafen) during the initial period of intense L-thyroxine replacement therapy on clinical symptoms of thyroid insufficiency, lipid metabolism value, haemodynamics, myocardial contraction ability has been stated. Key words: hypothyroidism, cardiovascular system, haemodynamics, systolic time intervals, thyroxine, cordafen.

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