.

Вплив інтенсивної замісної терапії L-тироксином сумісно з антагоністом кальцію (кордафеном) на функціональний стан серцево-судинної системи при гіпоти

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AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO AIAeIE?EIIEIA?? OA IAI?IO ?A*IAEI ?I. A.I.EII?NA?AIEA

Ie?eieeiaa Na?oeaia Iao??aia

Aieea ?ioaineaii? cai?nii? oa?ai?? L–oe?ieneiii noi?nii c aioaaii?noii
eaeueoe?th (ei?aeaoaiii) ia ooieoe?iiaeueiee noai na?oeaai-noaeeiii?
nenoaie i?e a?iioe?aic?

14.01.14 – AIAeIE?EIIEIA?ss

aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a -1999

Aeena?oaoei?th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio ?inoeooo? oaeineiiaeaiiy e?ea??a IIC
Oe?a?ie, Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo oa?iaeioa?ai??
aiaeie?eiieo caoai?thaaiue

Iaoeiaee ea?iaiee: A?eaoeueea Ieueaa Ieoaee?aia, aeieoi? iaaee/ieo iaoe,
Oa?e?anueeee ?inoeoo oaeineiiaeaiiy e?ea??a, caa?aeoth/a
eaoaae?ith aiaeie?eiieia??.

Ioioeieii iiiiaioe: Aiaeia? Iao?i Ieeieaeiae/, aeieoi? iaaee/ieo iaoe,
i?ioani?, Iaoe?iiaeueiee iaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey,
caa?aeoth/ee eaoaae?ith aiaeie?eiieia??

Cae?inueeee Ai?en Ieaen?eiae/, aeieoi? iaaee/ieo iaoe, i?ioani?,
A?iieoeueeee iaaee/iee oi?aa?neoao ?i. I.?.Ie?iaiaa, caa?aeoth/ee
eaoaae?ith aiaeie?eiieia??

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.
Ae.Aaeeoeueeiai , eaoaae?a aiaeie?eiieia??.

Caoeno aiaeaoaeaoueny “ 2 “ ethoiai 1999 ?. i 13 aiaeeii ia caniaeaiii
niaoeiaeiciaaii? a/aii? ?aaee Ae 26.558.01 Iinoeoooo aiaeie?eiieia?? oa
iai?io ?a/iaei AII Oe?a?ie (254053, i. Ee?a, aoe.Aeoai?iaenueea 69).

C aeena?oaoei?th iiaeia iciaeiieoeny o aiaeiioaoei Iinoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei AII Oe?a?ie (254053, i. Ee?a, aoe.
Aeoai?iaenueea 69).

Aaoi?aoa?ao ?icineaiee “ 29 “ a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoeiaeiciaaii? a/aii? ?aaee,

aeieoi? a?ieia?/ieo iaoe
E.I. Eaeeinueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue oaie. Iaiaoiaeiinoue oaeineiiaeaiiy iaoiaeia caiinii?
oa?aii? oe?ai?aeii? iaaeinoaoiinoi iaaoaa? aaaeeeaiai cia/aiiy o ca’yceo
ic c?inoaiiyi eieueeinoi oai?eo ia ia?aeiiee aiiioe?aic oa
iaaeinoaoiueith aoaeoeaiinoth eiai eieoaaiiy.

Oae, ia i?ioyci aeiaaiai /ano aeei?enoaiiy ??cieo iaoiaeee e?eoaaiiy
oe?ai?aeeiii ia aeaei aaaeaieo ?acoeueoao?a. Ai?iaaaeaeaiiy a i?aeoeeo o
60-70-o ?ieao neioaoe/iiai O3 oa eiiaiiiaaieo oe?ai?aeieo i?aia?aoia
(oe?aioiio oa oe?aieiiao) oaeiae ia aeicaieeei aeinyaoe o oai?eo ia
aiiioe?aic aeinoaoiuei aeniei? oiea?aioiinoi aei caiinii? oa?aii?
[J.Baillet et al.,1981], o ca’yceo c /ei iaaoea oe?ieiai
?iciianthaeaeaiy iaoiaeeea “iaeeo” aeic oe?ai?aeieo ai?iiiia ia ii/aoeo
eieoaaiiy aiiioe?aico [O.Oaiaao ic niiaaao., 1988; I.O.Noa?eiaa, 1991;
H.Bethge, 1984].A iiaeaeueoiio o oai?eo c oe?ai?aeiith iaaeinoaoiinoth
aoea aeyaeaia aieueo aeniea ia?aiineiinoue L-oe?ieneio (L-O4).
Anoaiiaeaii, ui i?e eiai i?ecia/aiii c?inoaiiy eiioeaio?aoei? O3 a e?iai
iiaeaeuo?oueny iiaieueii i aeinyaa? ii?iaeueiiai iieacieea oieueee /a?ac
3-4 oeaeii iiney anoaiiaeaiiy iaiaoiaeiiai ?iaiy oe?ieneiaii? aeey
iiaii? eiiiainaoei? aiiioe?aico. [O.Oaiaao ic niiaaao., 1988;
U.M.Kaplan,1984].

Iiaieueiee aiii?e/iee iiaeai? aaeaeaaoiiai aeicoaaiiy oe?ai?aeieo
i?aia?aoia iaoiiaeth? aeiaai no?iee (a?ae 2,5 i?nyoe?a aei ?ieo)
?aaaieioaoei? oai?eo [O.Oaiaao ic niiaaao., 1988; I.O.Noa?eiaa, 1991;
R.Hebrmann, 1988].

I?eeiath/e aei oaaae iniaeeainoi iaoaaieicio aeciaaiiiai O4 ia ii/aoeo
eieoaaiiy aiiioe?aico, aoea ai?iaaaeaeaia iaoiaeeea iioaineaii? caiicii?
oa?aii? L-T4, yea aeicaiey? c a?aooaaiiyi nooiaith oe?ai?aeii?
iaaeinoaoiinoi oa aaae oiea oai?iai ia i?ioyci 3-7 aeiia eieaiaeoaaoe
aeaoioeeo oe?ai?aeieo ai?iiiia a i?aaiicii, iicey oeueiai ia?aoiaeeoe ia
iiaeo?eioth/i aeice [I.I. Aieaoeueea, 1994, 1996]. I?e
caaeiaieueiie ia?aiineiinoi L-O4 oaea oa?aiaaoe/ia oaeoeea aeicaiey?
cia/ii nei?ioeoe ia?iiae eiiiainaoei? aiiioe?aico.

Iaeiae, a ?yaei aeiaaeeia oaeiae aeieea? iaiaoiaeiinoue a iioeiicaoei?
ii/aoeiaiai ia?iiaeo oa?aii? aiiioe?aico L-O4 (ia?aae anueai o eioiio
oai?eo c oyaeeith oi?iith oe?ai?aeii? iaaeinoaoiinoi oa ae?aaeaiei
ii?ooaiiyi ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie).

I?eeiath/e aei oaaae oie oaeo, ui aeecaaeaioaoeiy aei caiinii? oa?aii?
aiiioe?aico /anoioa oa?aeoa?eco?oueny na?oeaaeooyi, iineeaiiyi aai
c’yaeaiiyi aieth a aeieyioei na?oey, aeieea? iioa?an aieueo iiaeeaeaii
aea/eoe oa?aeoa? aiaeiiaeaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii?
nenoaie i?e aeei?enoaiii iaoiaeeee iioaineaii? caiinii? oa?aii?
aiiioe?aico L-T4 ia i?ioyci 4-5 oeaeiia aiae ii/aoeo eieoaaiiy.

Aiaeiii, ui aaaeeeao ?ieue a iaoaiicii iiieaeaii? oiea?aioiinoi oai?eo
ia aiiioe?aic aei caiinii? oa?aii? oe?ai?aeieie ai?iiiaie aiaeia?athoue
iiaeaeuaiiy /ooeeainoi oeaiei aei eaoaoieaiiiia, caieueoaiiy iio?aae
iiiea?aea a eenii oa iiaeeaieo ?a/iaeiao, a oaeiae i?enei?aiee o?ainii?o
eaeueoeith a eeioeie [I.O.Noa?eiaa, 1989; I.Klein et al., 1984;
C.T.Sawin, 1985].

A?aoiaoth/e, ui i?aia?aoe a?oie aioaaiiinoia eaeueoeith ia oieueee
i?eaiaeyoue aei ni?eyoeeai? ciiie niiaaiaeiioaiiy iiiia eaeueoeith oa
eaeith a iiiea?aei, aea oaeiae iathoue caaaeueio ia?eoa?e/io
aaciaeieaooth/o aeith, a oiio /enei ?icoe?ththoue aiioeaai noaeeie oa
caieueoothoue ei?iia?iee e?iaiiaia [C.TH.Ia?oeaai/, 1990; E.O.Iaea ic
niiaaao., 1994; I.E.Oa?a?aa, 1995], iiaeia i/?eoaaoe, ui ?o i?ecia/aiiy
a eiiieaeni c L-T4, aoaea ni?eyoe iieiioaiith aaeaioaoei? aei caiinii?
oa?aii? oai?eo ia aiiioe?aic. I?aoeue ii aea/aiith aoaeoeaiinoi
aeei?enoaiiy aioaaiiinoia eaeueoeith noiinii c L-T4 o oai?eo ia
aiiioe?aic iaie ia ciaeaeaii.

Oaeei /eiii, ni?yiiaaiinoue aeaiiai aeineiaeaeaiiy aecia/a?oueny
iaiaoiaeiinoth iiaeeaeaiiai aea/aiiy ooieoeiiiaeueiiai noaio
na?oeaai-noaeeiii? nenoaie o oai?eo ia aiiioe?aic i?e aeei?enoaiii
iaoiaeeee oaeaeei? ii?iaeicaoei? oe?ai?aeieo ai?iiiia a i?aaiicii ca
aeiiiiiaith L-O4, a oaeiae aiaenooiinoth ?ic?iaie oeyoia iiaeaeuaiiy
oiea?aioiinoi aei iioaineaii? oa?aii? L-T4 ia ii/aoeo eieoaaiiy
aiiioe?aico.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeine?ae-aeaiiy
aeeiiaii ca?aeii ieaio iaoeiai-aeine?aeieoeueei? ?iaioe Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a oa Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo oa?iaeioa?ai?? aiaeie?eiieo
caoai?thaaiue, i.Oa?eiaa.

Iaoa aeineiaeaeaiiy. Ioe?iea aieeao iioaineaii? caiinii? oa?aii?
L-oe?ie-neiii noiinii c aioaaiiinoii eaeueoeith (ei?aeaoaiii) ia
ooieoeiiiaeueiee noai na?oeaai-noaeeiii? nenoaie o oai?eo ia aiiioe?aic.

Caaea/i aeineiaeaeaiiy:

1. Aea/eoe iniaeeainoi ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii?
nenoaie o oai?eo ia aiiioe?aic a caeaaeiinoi aiae nooiaiy oe?ai?aeii?
iaaeinoioiinoi oa oa?aeoa?o o?aaeaiiy ueoiaeaeii? caeice.

2. Aeineiaeeoe aeeiaiieo ?aa?ani? aiiioe?aico c o?aooaaiiyi
ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie ia ii/aoeo (ia
i?ioyc? iaeiiai i?nyoey) iioaineaii? caiinii? oa?aii? L-T4.

3. Aea/eoe aeeiaiieo ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie
a i?ioeani iioei?ciaaiiai canoinoaaiiy L-T4 noiinii c aioaaiiinoii
eaeueoeith (ei?aeaoaiii) ia ii/aoeo caiinii? oa?aii? aiiioe?aico.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa ia i?aenoaa? eiiieaeno ?ino?oiaioaeuei?o iaoiae?a ianoaaeaiiy o
oai?eo ia aiiioe?aic i?iaaaeaii ii??aiyeueio ioe?ieo ooieoe?iiaeueiiai
noaio na?oeaai-noaeeiii? nenoaie a caeaaeiino? a?ae oa?aeoa?o o?aaeaiiy
ueoiaeaeii? caeice.

Iaoeiai iaa?oioiaaii aeioe?euei?noue aeeth/aiiy aei eiiieaeno
ianoaaeaiiy iieaciee?a aaiiaeeiai?ee oa oaciai? no?oeoo?e nenoiee e?aiai
oeoii/ea na?oey i?e ?ioaineai?e cai?ni?e oa?ai?? a?iioe?aico L-O4.

Aeyaeaii, ui iioaineaia caiinia oa?aiiy L-T4 ia oieueee iieiioo?
caaaeueiee noai oai?eo ia aiiioe?aic oa i?eaiaeeoue ?o aei
aooe?ai?aeiiai noaio, aea e a cia/iie ii?i ii?iaeico? oeaio?aeueio oa
aioo?ioiueina?oeaao aaiiaeeiaiieo aaea /a?ac 2-3 oeaeii, a iieacieee
o?iiiea?ae?ia?ao?? – a na?aaeiueiio /a?ac iaeei i?nyoeue aiae ii/aoeo
eieoaaiiy.

Aia?oa canoiniaaii niin?a iioei?caoe?? ?ioaineaii? cai?nii? oa?ai?? L-O4
ia ii/aoeo e?eoaaiiy; anoaiiaeaii, ui aeiaeaoeiaa i?ecia/aiiy
aioaaii?noa eaeueoe?th (ei?aeaoaia) ni?ey? nei?i/aiith no?ieia
aiaeiiaeaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie o oai?eo
ia a?iioe?aic.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iieacaia aoaeoeaiinoue
i?iaaaeaiiy o oai?eo ia aiiioe?aic eiiaiiiaaii? oa?aii?, yea aeeth/a?
canoinoaaiiy L-O4 a iioaineaiiio ?aaeeii oa aioaaiiinoa eaeueoeith
(ei?aeaoaia). I?ecia/aiiy aioaaiiinoa eaeueoeith (ei?aeaoaia) ia ii/aoeo
caiinii? oa?aii? aiiioe?aico aeicaieeoue nei?ioeoe no?ie ?aaaieioaoei?
oai?eo oa iieiioeoe oiea?aioiinoue aei L-T4.

Iieacaia aeioeieueiinoue aeineiaeaeaiiy o oai?eo ia aiiioe?aic
iieacieeia aaiiaeeiaiiee oa nei?i/oaaeueii? caeaoiinoi iiiea?aea ia
ii/aoeo caiinii? oa?aii?, ui aeicaieeoue aecia/eoe no?iee eieaiaeaoei?
aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii oa ioeiithaaoe
aaeaeaaoiinoue i?iaaaeaiiy caiinii? oa?aii?.

?acoeueoaoe iaoeiaeo aeineiaeaeaiue oi?iaaaeaeaii: a eeiiioei oa
eiinoeueoaoeaiie iieieeiiioei Oe?a?inueeiai iaoeiai-aeineiaeiiai
?inoeoooo oa?iaeioa?aii? aiaeie?eiieo caoai?thaaiue, 27-e oa iaeaniie
eeiii/ieo eiea?iyo i.Oa?eiaa, iieieeiiioei N 3 i.Oa?eiaa, iaaenai/anoeii
N 12 i.Oa?eiaa, a oaeiae aeeeaaeathoueny ia oeeeeao iineyaeeieiiiiai
iaa/aiiy eaoaae?ith aiaeie?eiieiai? Oa?eianueeiai iinoeoooo
oaeineiiaeaiiy eiea?ia.

Iniiaii iieiaeaiiy aeena?oaoei?, ui aeiinyoueny ia caoeno:

1. O oai?eo ia aiiioe?aic ia? iinoea caeaaeiinoue iieacieeia
aaiiaeeiaiiee oa oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey ia
o?eueee aiae nooiaiy oe?ai?aeii? iaaeinoaoiinoi, aea e oa?aeoa?o
o?aaeaiiy ueoiaeaeii? caeice.

2. Canoinoaaiiy L-T4 o oai?eo ia aiiioe?aic o aeicoaaiii, ui ia?aaeaa/a?
eieaiaeaoeith aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii ia i?ioyci 3-7
aeiia, i?eaiaeeoue aei ii?iaeicaoei? ooieoeiiiaeueiiai noaio
na?oeaai-noaeeiii? nenoaie a na?aaeiueiio ia i?ioyci iaeiiai iinyoey
iacaeaaeii a?ae oyaeeino? caoai?thaaiiy oa oa?aeoa?o o?aaeaiiy
ueoiaeaeii? caeice.

3. Aeeth/aiiy a eiiieaenia eieoaaiiy oai?eo ia aiiioe?aic aioaaiiinoa
eaeueoeith (ei?aeaoaia) aea? aieueo ae?aciee iiceoeaiee aoaeo ia
a?aeiiaeaiiy ooieoeiiiaeueiiai noaio na?oeaai-noaeeiii? nenoaie a
ii??aiyii? c iiiioa?ai??th L-O4.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii iniaenoi ?ic?iaeaia i?ia?aia
aeineiaeaeaiiy, i?iaiaeeeinue eieoaaiiy i niinoa?aaeaiiy ca aniia
ianeiaeoaaieie oai?eie, naiinoieii aeeiioaaeinue aeineiaeaeaiiy
na?oeaai-noaeeiii? nenoaie, c?iaeaii aiaeic ?acoeueoaoia eeiii/iiai,
ooieoeiiiaeueiiai, aiioiii/iiai, iioii-eiai/iiai i ai?iiiaeueiiai
ianoaaeaiiy. Aaoi?ii iniaenoi noi?ioeueiaaii ani iieiaeaiiy oa aeniiaee
aeena?oaoei?. Aaoi?o iaeaaeeoue aieiaia ?ieue o i?aeaioiaoe? io?eiaieo
aeaieo aei an?o iaoeiaeo ioae?eaoe?e.

Ai?iaaoeiy ?acoeueoao?a aeena?oaoe??. Iniiaii iieiaeaiiy aeena?oaoei?
iaaiai?aii ia eeiii/iie eiioa?aioei? Oe?a?inueeiai IAeI oa?iaeioa?aii?
aiaeie?eiieo caoai?thaaiue niieueii c eaoaae?ith aiaeie?eiieiai?
Oa?eianueeiai iinoeoooo oaeineiiaeaiiy eiea?ia (1996). Iaoa?iaee
aeena?oaoei? aeiiiaiaeaeenue ia iaoeiaie eiioa?aioei?, i?enay/aiie
25-eiooth iiai? eeiiiee Oe?a?inueeiai IAeI oa?iaeioa?aii? aiaeie?eiieo
caoai?thaaiue (1993), caniaeaiiyo Oa?eianueeiai iaoeiaiai iaaee/iiai
oiaa?enoaa ea?aeiieiaia (1993, 1996) oa aiaeie?eiieiaia (1996),
can?aeaii? eaoaae?e aiaeie?eiieia?? Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i. I.I.Aiaiiieueoey (Ee?a, 1998).

Ioaeieaoei?. Ca iaoa??aeaie aeena?oaoei? iioaeieiaaii 12 iaoeiaeo ?iaio,
c yeeo /ioe?e noaoo? a iaoeiaeo oaoiaeo aeo?iaeao, ui caoaa?aeaeai? AAE
Oe?a?ie, o?e noaoo? o ca??ieeao iaoeiaeo i?aoeue, iaeei ?ioi?iaoe?eiee
eeno oa /ioe?e oace.

Ianya i no?oeoo?a aeena?oaoe??. Aeena?oaoeiy iaae?oeiaaia ia 154
noi?iieao iaoeiiieno i neeaaea?oueny ic anooio, iaeyaeo eioa?aoo?e,
iaoa?iaeia i iaoiaeia aeineiaeaeaiiy, 3 aeaa aeanieo aeineiaeaeaiue,
caeii/aiiy, aeniiaeia oa i?aeoe/ieo ?aeiiaiaeaoeie. Cienie eioa?aoo?e
aeeth/a? 204 aeaea?aea aio/eciyieo i ca?oaiaeieo aaoi?ia. ?iaioa
iethno?iaaia 10 ?enoieaie oa 25 oaaeeoeyie.

CIINO ?IAIOE

Eeiii/ia oa?aeoa?enoeea ianeiaeoaaieo. Ia’?eoii aeineiaeaeaiiy aoee 107
oai?eo ia ia?aeiiee aiiioe?aic, ianoaaeaiiy yeeo i?iaiaeeeinue a
eeiiioei Oe?a?inueeiai iaoeiai-aeineiaeiiai iinoeoooo oa?iaeioa?aii?
aiaeie?eiieo caoai?thaaiue.

O ianoaaeaieo ia?aaaaeaa a?e a?ae 41 aei 50 ?ie?a, a ni?aa?aeiioaiiy
/ieia?e?a oa ae?iie neeaaeaei 1:4. O ia?aaaaeii? aieueoinoi oai?eo (40
/ie. – 37,4%) o?eaaeinoue caoai?thaaiiy aoea aiae 3-o aei 9-oe ?ieia. O
32 iaoei?ioia (29,9%) aeyaeaii niiioaiiee aiiioe?aic (1 iiaea?oia), o 23
(21,5%) – aiiioe?aic ia oiii aooiiioiiiai oe?ai?oeaeo (2 iiaea?oia).
Iineyiia?aoeieiee aiiioe?aic aoa o 52, ic ieo o 29 (27,1%) aiiioe?aic
aeiee iiney oi?o?ai/iiai eieoaaiiy aeeoociiai oiene/iiai ciaa (3
iiaea?oia), o 23 (21,5%) – aooiiioiiiai oe?ai?aeeoo (4 iiaea?oia).

Eaaea oi?ia aiiioe?aico aeyaeaia o 8 iaoei?ioia (7,5%), aiiioe?aic
na?aaeiuei? oyaeeinoi – o 60 (56,1%), oyaeea oi?ia – o 39 (36,4%).

O 26 inia (24,3%) noiooiiie caoai?thaaiiyie aoea ?oai?/ia oai?iaa na?oey
(ION), o 39 oai?eo (36,4%) – a?oa?iaeueia aiia?oaiciy.

Aoaeoeaiinoue ii/aoeiai? caiinii? oa?aii? aiiioe?aico iiaeeaiaeoaeueii
aecia/aieie aeicaie L-T4 aea/aii o 45 oai?eo, yei neeaee eiio?ieueio
a?oio. O 27 inia aeyaeaii aiiioe?aic na?aaeiuei? oyaeeinoi, o 18 –
oyaeea oi?ia.

Aeey i?iaaaeaiiy ioeiiee ?icieo iaoiaeia caiinii? oa?aii? i?e
aiiioe?aici aoei ianoaaeaii 40 oai?eo aiiioe?aicii, yei aaeeaaee L-T4 ii
o?aaeeoeieiie iaoiaeeoei (iiaieueia caieueoaiiy aeice).

Ooieoeiiiaeueiee noai na?oeaai-noaeeiii? nenoaie aea/aii o 60 oai?eo
aiiioe?aicii na?aaeiuei? oyaeeinoi i 39 inia ic oyaeeith oi?iith
caoai?thaaiiy.

Aeineiaeaeaii aoaeoeaiinoue canoinoaaiiy aioaaiiinoa eaeueoeith
ei?aeaoaia a ii?aeiaiii ic L-T4 ia ii/aoeo caiinii? oa?aii?, yea
i?iaiaeeeanue a iiaeeaiaeoaeueiiio ?aaeeii i ia?aaeaa/aea onoiaiiy
aeaoioeeoo oe?ai?aeieo ai?iiiia a i?aaiicii i?ioyaii 3-7 aeiia.

Ia?oo eiio?ieueio a?oio (50 inia) neeaee iaoei?ioe, eio?i io?eioaaee
oieueee L-T4 a iiaeeaiaeoaeueiie aeici. Eaaea oi?ia aiiioe?aico aeyaeaia
o 4 oai?eo, aiiioe?aic na?aaeiuei? oyaeeinoi – o 28 inia, oyaeea oi?ia –
o 18.

Ae?oaa ianoaaeaia a?oia neeaaeaea 57 inia, yei ?acii ic
iiaeeaiaeoaeueiith aeicith L-T4 aaeeaaee aioaaiiino eaeueoeith ei?aeaoai
(“Iieueoa”, 1 oaaeaoea iinoeoue 10 ia) a aeici 20-30 ia a aeaiue
i?ioyaii 21-28 aeiia. Eaaea oi?ia aeyaeaia o 4 oai?eo, aiiioe?aic
na?aaeiuei? oyaeeinoi – o 32 inia, oyaeea oi?ia o 21 iaoei?ioa.

Ca a?eii, o?eaae?noth, aaaee?noth, oa?aeoa?ii o?aaeaiiy ueoiaeaeii?
caeice oa iayai?noth noiooiuei? iaoieia?? a?oie aoee noaoenoe/ii
iaeii??aei?.

Aeey ii?iaiyiiy iaea?aeaieo ?acoeueoaoia aoea ianeiaeoaaia a?oia
i?aeoe/ii caei?iaeo ethaeae (25 inia).

Iaeaieueo /anoeie nea?aaie oai?eo aoei aiae/oooy caaaeueii? neaaeinoi
(92,5%), ia?ceyeoaaoinoue (63,6%), niieeainoue (82%), iaa?ye iaee//y i
eiioeiaie (73,8%), nooinoue oei?e (71,9%), iaaeeeoeiaa aaaa oiea
(52,3%), caii?e (47,7%). Nea?ae ia aieue a aeieyioei na?oey i?aae’yaeyee
64 (59,8%) oai?eo ia aiiioe?aic. O 62 (57,9%) iaoei?ioia aeyaeyeanue
a?aaeeea?aeiy, o 8 (7,5%) – oaoiea?aeiy.

Aiaeic eeiii/ii? neiioiiaoeee ?icieo aa?iaioia aiiioe?aico iieacaa, ui
iaeaieueo ae?aaeai? eeiii/i? i?iyae niinoa?iaaeenue i?e niiioaiiiio
aiiioe?aici oa aiiioe?aici, ui aeiee iiney iia?aoei? c i?eaiaeo
aeeoociiai oiene/iiai ciaa.

Iaoa?iaee oa iaoiaee aeineiaeaeaiiy. ?iaaiue oe?io?iiiio,
o?eeiaeoe?iiiio i oe?ieneio aecia/aee ?aaeiiiioiieiai/iei iaoiaeii c
aeei?enoaiiyi noaiaea?oieo oano-iaai?ia: RIA-mat TSH (Iiia//eia),
PIO-T3-IA (Aiei?onue), PIO-T4-IA (Aiei?onue).

Aioeoiea aei oe?aiaeiaoeiio i iie?iniiaeueiiai aioeaaio aeine?aeaeaii
iio-iioa?iaioiei iaoiaeii.

Eiiiaeiee iaiii aea/aee oeyoii aecia/aiiy caaaeueiiai oieanoa?eio (ON) a
ne?iaaooei e?iai iaoiaeii Ieueea, aaoa-eiiii?ioa?aee (A-EI) – ii
Ao?ooaeio i Naiath.

Aeaeo?iea?ae?ia?ao?y i?iaiaeeeanue ca caaaeueiii?eeiyoith iaoiaeeeith.

Aeey aea/aiiy iieacieeia oeaio?aeueii? aaiiaeeiaiiee canoiniaoaaee
oao?aiiey?io a?oaeio ?aia?aoith ca iaoiaeii W.G.Kubicek a iiaeeoieaoei?
TH.O.Iooea?y. C oei?th iaoith aeei?enoiaoaaee ?aia?ao ?IA-2-02 c
?aaino?aoi?ii 6-NEK. Aea/aeenue oaei iieacieee: oaea?iee ia’?i (OI, ie),
oaeeeiiee ia’?i e?iai (OIE, e/oa), oaea?iee iiaeaen (OI, ie/i2),
na?oeaaee iiaeaen (NI, e/oa/i2), caaaeueiee ia?eoa?ieiee noaeeiiee iii?
(CINI, aeei·n·ni-5), na?aaeiie aaiiaeeiaii/iee oene (NAAeO, ii ?o.no.).

Aeey aeineiaeaeaiiy oaciai? no?oeoo?e nenoiee eiaiai oeoii/ea na?oey
i?iaiaeeeanue o?iiiea?aeiia?aoiy. Oaciaee aiaeic caeienithaaee ca
iaoiaeii A.E.Ea?iiaia. Aea/aee ia?aiao?e: oaca aneio?iiiiai oa
iciiao?e/iiai nei?i/aiiy (AN oa IC, n), ia?iiae iai?oae (O, n), ia?iiae
aeaiaiiy (A, n), iaoaii/ia i caaaeueia nenoiea (Sm oa So, c).
?ic?aoiaoaaeenue iiaeoaciai iieacieee: iaoaii/iee eiaoioei?io (IE),
aioo?ioiueinenoiei/iee iieaciee (ANI, %), iiaeaen iai?oae iiiea?aea
(III, %).

Aeey aea/aiiy ii?oieiai/ieo no?oeoo? i aioo?ioiueina?oeaai?
aaiiaeeiaiiee canoiniaoaaee iaoiae aoiea?aeiia?aoi? (a A- oa I- ?aaeeii)
ia aia?aoi “Aloka-SSD-280” (ssiiiiy) c aeei?enoaiiyi aeao/eea ic
/anoioith 3 iAoe i eooii ?icai?oee 80 a?aaeonia ii caaaeueiii?eeiyoie
iaoiaeeoei. Aea/aeenue oaei iieacieee: eiioeaaee nenoiei/iee i eiioeaaee
aeianoie?/iee ia’?i (ENI i EAeI), o?aeoeiy aeeeaeo (OA, %), nooiiiue
oei?i/aiiy ia?aaeiuei-caaeiueiai ?icii?o eiaiai oeoii/ea (NOEO, %),
oaeaeeinoue oei?i/aiiy oee?eoeyoi?ieo aieieii iiiea?aea (OOOeA, eiei/n).

Iienaii iaoiaee aeineiaeaeaiiy canoiniaoaaeeny o oai?eo aei i?ecia/aiiy
eieoaaiiy, ia 14-21 aeaiue i 28-35 aeaiue aiae ii/aoeo oa?aii?.

Aeey ?ic?aooieo iiaeeaiaeoaeueieo aeic L-T4 aeei?enoiaoaaeenue oi?ioee,
yei aeicaieyee aecia/eoe ii/aoeiao oa iiaeo?eioth/o aeice (Aei i Aei)
i?aia?aoo c o?aooaaiiyi aacaeueii? eiioeaio?aoei? O4 a e?iai oa aaae
oiea oai?iai:

Aei = 10 iea·I – 100·L

Aei = 4 iea·I – 50·L,

aea I – aaaa oiea oai?iai (ea), L – aeiaiacii eiioeaio?aoei? O4 a
ne?iaaooei e?iai:

L = 1 i?e Ni F 10 iiieue/e,

L = 2 i?e 10

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