1

AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OA?IAEIEIA?? OA OIENEEIEIA??

Ia i?aaao ?oeiieno

IAAeA?AeUe C?ia?aea Noaiai?aia

AIEEA ?IA?A?OI??A I?E?INIIAEUeIEO IIIIIECEAAIAC IA OA?IAEIE?IAOEEO OA
OA?IAEIAeEIAI?EO IE?AIEO AIAEUeAAOEE?A OA AIANOAOEE?A

14.03.05 — oa?iaeieia?y

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyeaiaeeaeaoa
a?ieia?/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a A?iieoeueeiio aea?aeaaiiio iaaee/iiio

oi?aa?neoao? ?i. I.?.Ie?iaiaa

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe Noai?neaa/oe Ieeiea Aaeaiiae/

aeioeaio eaoaae?e oaeoeueoaonueei? oa?ai??? A?iieoeueeiai aea?aeaaiiai

iaaee/iiai oi?aa?neoaoo ?i.I.?.Ie?iaiaa

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, i?ioani? Iaiothe Ieaenaiae? Ieaen?eiae/

caa?aeoaa/ eaai?aoi??? ?inoeoooo o?i?? iiaa?oi? IAI Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? a?ieia?/ieo iaoe, i?ioani?, aeaaeai?e AII Oe?a?ie

Aieiaaiei Ieeiea sseiae/ — caa?aeoaa/ o?ceei-o?i?/ii? eaai?aoi???
o?ceei-o?i?/iiai ?inoeoooo IAI Oe?a?ie

aeieoi? iaaee/ieo iaoe Eeoaeiiaa Iaae?y Aieiaeeie??aia noa?oee iaoeiaee
ni?a?ia?oiee a?aeae?eo a?io?i?/ii? oa?iaeieia?? ?inoeoooo oa?iaeieia??
oa oieneeieia?? AII Oe?a?ie

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. ae.
I.I.Aiaiiieueoey

Caoeno aeena?oaoe?? a?aeaoaeaoueny » 12 » n?/iy 1999 ?ieo i 13-00 aiae
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.550.01 i?e ?inoeooo?
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, Ee?a, aoe. ?.Iioue?,
14)

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie

Aaoi?aoa?ao ?ic?neaii » 11 » a?oaeiy 1998 ?.

O/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

Ae.26.550.01, e.a.i.
?.A.Aeaiiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. A no/ani?e oa?iaeioa?ai?? ia?aaaaea?
oaiaeaioe?y aei eiia?iiaaiiai canoinoaaiiy e?ea?nueeeo cania?a ??cieo
oa?iaeieia?/ieo a?oi. Iaeiae, oa?iaeie?iaoe/i? iaoai?cie aca?iiae??
i?aia?ao?a i?e ?o iaeii/aniiio canoinoaaii? aea/ai? iaaeinoaoiuei.

Iniaeeai? aeooaeueiino? i?iaeaia oa?iaeie?iaoe/ii? oa
oa?iaeiaeeiai?/ii? ?ioa?oa?aioe?? iaaoaa? aeey caaaeueieo aianoaoee?a,
ye? iathoue a?aeiinii aocueeee oa?aiaaoe/iee ae?aiacii ? i?e oeueiio
aeineoue /anoi ii?aeiothoueny c ?ioeie e?ea?nueeeie caniaaie. Cie?aia,
iaoe??ioe o??o?a?/ieo noaoe?iia??a ia aoai? i?aeaioiaee aei iia?aoe??,
i?ae /an oa i?ney iia?aoeaiiai ao?o/aiiy io?eiothoue ia iaioa 10 ??cieo
iaaeeeaiaio?a (Wood M., 1991), ui ?iaeoue iane?aeee eiia?ioaaiiy oaei?
e?eueeino? i?aia?ao?a ia caaaeaee ia?aaeaa/oaaieie. Na?aae i?aia?ao?a,
ui iaeii/anii canoiniaothoueny ?acii c aianoaoeeaie iiaeooue aooe
e?ea?nuee? ?a/iaeie c aeanoeainoyie iiaeoeyoi??a aeoeaiino? oa?iaio?a
iaoaaie?cio enaiia?ioee?a. I?ae oei oa?iaeieia?/iee aoaeo oaeeo
aianoaoee?a ye aaenaiae oa eaoai?i o?nii iia’ycaiee c ?o
a?io?ainoi?iaoe??th ? aecia/a?oueny, aieiaiei /eiii, oaeaee?noth
ia?aoai?aiiy a oa?iaeieia?/ii iaaeoeaio oi?io (Zilly, Richter, 1992;
Korkmaz et al., 1995; Agrawal A.K., Shapiro B.H., 1996). Aiaeia?/iei
/eiii, a iaaeoeai? iaoaaie?oe a i?ioean? a?io?ainoi?iaoe??
ia?aoai?th?oueny a?eueo?noue iaia?eioe/ieo aiaeueaaoee?a oa
ianoa?i?aeieo i?ioecaiaeueieo i?aia?ao?a, oe?ioa canoinoaaiiy yeeo
oaeiae ia?aaeaa/a? aenieo eiia??i?noue ii?aeiaiiy c ?ioeie e?ea?nueeeie
caniaaie. A ?acoeueoao? I-aeaiaoeethaaiiy iaeiioe?ai?oee ianoa?i?aeiee
i?ioecaiaeueiee i?aia?ao ?iaeiiaoaoeei o?ainoi?io?oueny a iaaeoeaiee
iaoaaie?o O-aeaciaoee?iaeiiaoaoeei. ?iaeoeoe?y /e aeieoaaiiy
iaoaaie?coth/eo oa?iaio?a, a ia?oo /a?ao oeeoio?ii ?-450-caeaaeieo
iiiiieneaaiac, iiaea ?noioii aieeiooe ia oa?iaeie?iaoeeo oa aaee/eio
oa?iaeieia?/iiai aoaeoo oaeeo i?aia?ao?a.

A aeayeeo aeine?aeaeaiiyo aoea i?iaeaiiino?iaaia caeaoi?noue ?iaeoeoi?a
oaiiaa?a?oaeo nei?i/oaaoe o?eaae?noue ia?eioe/ii? ae?? aaenaiaeo oa
eaoai?io (A.E.Ethaeiia e niaao., 1992), iieacaii caeaaei?noue
oa?iaeieia?/iiai aoaeoo ie?aieo ianoa?i?aeieo i?ioecaiaeueieo i?aia?ao?a
(IICI) a?ae aeoeaiino? i?e?iniiaeueieo iiiiieneaaiac (I.A.Noai?neaa/oe,
1996). Aeine?aeaeaiiyie inoaiiueiai aeanyoee?ooy aoea iieacaia
iayai?noue iiiaeeiieo oi?i oeeoio?iio ?-450 oa ?ioeo oa?iaio?a
iaoaaie?cio enaiia?ioee?a (O.Sakuma et al., 1995; Y.Yamamoto, et al.,
1995; V.Longo et al., 1997), i?iaeaiiino?iaaia ?o niaoeeo?/i?noue ia
o?eueee uiaei iaaieo noano?ao?a, aea e aei ?ia?a?oi??a oa ?iaeoeoi??a
(I.ss.Aieiaaiei, 1988, 1998; T.Chang at al., 1992; A.Draper et al.,
1997). Aaaeooueny ?ioaineai? aeine?aeaeaiiy ii c’ynoaaiith i?e/aoiino?
oeo /e ?ioeo ?cioi?i oeeoio?iio ?-450 aei iaoaaie?cio e?ea?nueeeo
i?aia?ao?a oa oieneeaio?a (K.Inoue et al., 1997; J.Schmider et al.,
1997; D.Sohn et al., 1997). Iieacaii, ui a iaoaaie?ci? a?eueoino?
e?ea?nueeeo ?a/iaei (a oiio /ene? aianoaoee?a oa IICI) iiaea a?aoe
o/anoue e?eueea ?cioa?iaio?a oeeoio?iio ?-450. Oe? ianoaaeie i?aeoe/ii
oiaiiaeeeaeththoue ai??i?ia i?iaiicoaaiiy iane?aee?a oa?iaeie?iaoe/ii?
aca?iiae?? aianoaoee?a /e IICI c ?ioeie e?ea?nueeeie i?aia?aoaie,
noano?aoaie aai iiaeoeyoi?aie oeeoio?iio ?-450.

Caeeoa?oueny i?aeoe/ii ia aea/aiei ieoaiiy aca?iiae?? aianoaoee?a
(eaoai?io oa aaenaiaeo) oa ianoa?i?aeiiai i?ioecaiaeueiiai i?aia?aoo
?iaeiiaoaoeeio c ?ia?a?oi?aie oa?iaio?a iaoaaie?cio enaiia?ioee?a ia
??ai? ?o a?io?ainoi?iaoe??, oa?iaeie?iaoeee oa oa?iaeiaeeiai?ee, ia
c’yniaaia i?eiaeaaei?noue oeeoio?ii?a, ui iaoaaie?cothoue oe? i?aia?aoe,
aei o??? /e ?ioi? ?iaeeie oeeoio?iio ?-450.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeine?aeaeaiiy aeeiiaii o a?aeiia?aeiino? aei Aea?aeathaeaeaoii? IAe?
A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo NI 15.02.0001.86; ?
Aea?ae?a?no?aoe?? 01.86.0.33161.

Iaoa ?iaioe: aenia?eiaioaeueia iaa?oiooaaiiy i?aeoiae?a aei
oe?eani?yiiaaii? ei?aeoe?? oa?iaeieia?/iiai aoaeoo aianoaoee?a oa
aiaeueaaoee?a, noano?ao?a oeeoio?iio ?-450, oa i?iaiicoaaiiy ?o
oa?iaeie?iaoe/ii? ? oa?iaeiaeeiai?/ii? aca?iiae?? c ?ioeie e?ea?nueeeie
i?aia?aoaie, ui iathoue aeanoeaino? ?ia?a?oi??a i?e?iniiaeueieo
iiiiieneaaiac.

Iniiai? caaea/? aeine?aeaeaiiy:

1. Ioe?ieoe aieea ?ia?a?oi??a (oeeiaoeaeeio, ?ai?oeaeeio,
oei?aioai?eieo, eeio?eiacieo, aeeaoeeaeeo?iea?aaiaoo, eiaaeueoo
oei?eaeo, o?ai?iaeeoinoaoo) oa ?iaeoeoi??a (oaiiaa?a?oaeo, aaici??aio,
aoeaoiio, aeaenaiaoaciio oa ??oaii?oeeio) ia aeoeai?noue oeeoio?ii
?-450-caeaaeieo iiiiieneaaiac, ui aa?ooue o/anoue a i?e?iniiaeueiiio
iaoaaie?ci? eaoai?io, aaenaiaeo, ai?aeii??eio oa ?iaeiiaoaoeeio.

2. Ia iniia? ?iaeoeoi?iiai, ?ia?a?oi?iiai oa ei?aeyoe?eiiai aiae?co
ioe?ieoe o/anoue ??cieo ?cioi?i oeeoio?iio ?-450 a ?aaeoe??
N-aeaiaoeethaaiiy eaoai?io oa I-aeaiaoeethaaiiy ?iaeiiaoaoeeio.

3. Aea/eoe aieea ?ia?a?oi??a ia niiae?eiee aoaeo eaoai?io oa
oa?iaeieia?/iee aoaeo ? oa?iaeie?iaoeeo aaenaiaeo, ?iaeiiaoaoeeio oa
ai?aeii??eio.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa i?iaaaeaii aaaaoi??aiaaa (a?io?ainoi?iaoe?y, oa?iaeie?iaoeea,
oa?iaeiaeeiai?ea) aea/aiiy aca?iiae?? iiaiaioi?ia oeeoio?iio ?-450
(oeeiaoeaeeio, ?ai?oeaeeio, oei?aioai?eieo eaoieiiacieo, eeio?eiacieo,
aeeaoeeaeeo?iea?aaiaoo, eiaaeueoo oei?eaeo oa o?ai?iaeeoinoaoo) c
aianoaoeeaie aaenaiaeii oa eaoai?iii, aiaeueaaoeeaie ai?aeii??eiii oa
?iaeiiaoaoeeiii. Aeyaeaia aea??eia?noue aieeao oeeo ?ia?a?oi??a ia
iaoaaie?ci, oa?iaeie?iaoeeo oa oa?iaeieia?/iee aoaeo aianoaoee?a oa
aiaeueaaoee?a, yea aecia/a?oueny nii??aeiai?noth ?ia?a?oi??a aei oeo
?cioi?i oeeoio?iio ?-450, ui aa?ooue o/anoue a iaoaaie?/i?e ?iaeoeaaoe??
oeeo e?ea?nueeeo ?a/iaei.

Aia?oa c caeo/aiiyi iaoiaeo ?iaeoeoi?iiai, ?ia?a?oi?iiai oa
ei?aeyoe?eiiai aiae?co iieacaii, ui eeth/iaa ?aaeoe?y a?io?ainoi?iaoe??
eaoai?io (N-aeaiaoeethaaiiy) eaoae?co?oueny oa?iaioaie, ui iaeaaeaoue
aei i?ae?iaeeie oeeoio?ii?a ?4503A, a eeth/iaa ?aaeoe?y iaoaaie?cio
?iaeiiaoaoeeio — I-aeaiaoeethaaiiy — oa?iaioaie i?ae?iaeeie ?4502N.

Ia i?eeeaae? eeio?eiacieo i?iaeaiiino?iaaia iiaeeea?noue aeaiooaciiai
aieeao ?ia?a?oi??a ia oa?iaeieia?/io aeoeai?noue aianoaoee?a oa
aiaeueaaoee?a – iioaioe?thaaiiy a ia?o? aiaeeie i?ney aaaaeaiiy
?ia?a?oi??a oaa?eiai, oa ineaaeaiiy a iiaeaeueo? no?iee aeine?aeaeaiiy.

Aea/aii in vitro aieea ?ia?a?oi??a ia e?iaoeeo ?aaeoe?e
N-aeaiaoeethaaiiy eaoai?io oa ai?aeii??eio oa I-aeaiaoeethaaiiy
?iaeiiaoaoeeio i?e?iniiiith o?aeoe??th ia/?iee uo??a oa aoaeoe
?ia?a?oi??a ia oe? ?aaeoe?? a oe?e?niiio i?aai?ci? ? iieacaia
naeaeoeai?noue ?o aaeuei?aiiai aieeao.

Aia?oa ioe?iaia oa?iaeiaeeiai?/ia aca?iiae?y eaoai?io c oeeiaoeaeeiii,
?ai?oeaeeiii, oei?aioai?eieii, eaoieiiacieii, eiaaeueoo oei?eaeii,
o?ai?iaeeoinoaoii ? aeyaeaia a?aeiia?aei?noue iiaeoethth/i? ae?? oeeo
?ia?a?oi??a c aaee/eiith aaeuei?aiiai aieeao ia a?io?ainoi?iaoe?th
eaoai?io.

Iieacaii, ui a iniia? i?aeaeuaiiy ia?eioe/ii? ae?? aaenaiaeo ca oiia
eiai ii?aeiaiiy c ?ia?a?oi?aie oeeoio?ii ?-450-caeaaeieo iiiiieneaaiac,
eaaeeoue caeaoi?noue inoaii?o oiia?eueithaaoe iaoaaie?/io ?iaeoeaaoe?th
aianoaoeea ? i?aeaeuoaaoe eiioeaio?aoe?th a e?ia? oa ia/?ioe?
oa?iaeieia?/ii aeoeaii? oi?ie i?aia?aoo.

Aia?oa aeine?aeaeaia oa?iaeiaeeiai?/ia oa oa?iaeie?iaoe/ia
?ioa?oa?aioe?y ianoa?i?aeiiai i?ioecaiaeueiiai i?aia?aoo ?iaeiiaoaoeeio
c ?ia?a?oi?aie ??cieo o?i?/ieo a?oi ? ?ice?eo? iaoai?cie ?o aca?iiae??
ia ??ai? oa?iaioieo nenoai. Aeine?aeaeaia e?iaoeea I-aeaiaoeethaaiiy
?iaeiiaoaoeeio i?e?iniiiith o?aeoe??th ia/?iee uo??a ? aeyaeaii
aaeuei?aiee aieea oeeiaoeaeeio, oei?aioai?eieo, eeio??iacieo oa
o?ai?iaeeoinoaoo ia oeth ?aaeoe?th.

Iaoeiai-i?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Io?eiai? aeai? aenia?eiaioaeueii iaa?oioiaothoue iieiaeaiiy i?i
?ciaiceiniaoeeo?/iee oa?aeoa? aieeao ?ia?a?oi??a oeeoio?iio ?-450 ia
oa?iaeieia?/iee aoaeo aianoaoee?a eaoai?io oa aaenaiaeo, aiaeueaaoee?a
ai?aeii??eio oa ?iaeiiaoaoeeio.

Iieacaii, ui i?e eiia?ioaaii? aaenaiaeo, eaoai?io, ai?aeii??eio oa
?iaeiiaoaoeeio c ?ia?a?oi?aie i?e?iniiaeueieo iiiiieneaaiac aeieea?
oa?iaeiaeeiai?/ia oa oa?iaeie?iaoe/ia aca?iiae?y, a iniia? yei? eaaeeoue
iiaeeo?eaoe?y i?e?iniiaeueiiai iaoaaie?cio oeeo e?ea?nueeeo ?a/iaei.
Aeieaoi? I2-a?noai?iiaeo ?aoeaioi??a ?ai?oeaeei, yeee ia i?iyaey?
aaeuei?aii? aeoeaiino? uiaei aea/aieo iaie iiiiieneaaiac, aeyaeany ia
caeaoiei iiaeeo?eoaaoe oa?iaeie?iaoeeo oa oa?iaeieia?/iee aoaeo
aaenaiaeo, eaoai?io, ai?aeii??eio oa ?iaeiiaoaoeeio, oiae? ye ?ioee
aeieaoi? I2-a?noai?iiaeo ?aoeaioi??a — oeeiaoeaeei, yeee ? neeueiei
?ia?a?oi?ii aaaaoueio ?cioi?i oeeoio?iio ?-450, ni?aaey? ?noioiee aieea
ia ae?i?iaoe?th oa oa?iaeieia?/iee aoaeo oeeo e?ea?nueeeo i?aia?ao?a.

Anoaiiaeaii, ui aei ?aaeoe?? N-aeaiaoeethaaiiy eaoai?io i?e/aoi?
iiiiieneaaiace i?ae?iaeeie ?4503A, a aei ?aaeoe?? I-aeaiaoeethaaiiy
?iaeiiaoaoeeio — oa?iaioe i?ae?iaeeie ?4502N.

Ia i?eeeaae? eeio?eiacieo iieacaia iiaeeea?noue aeaiooaciiai aieeao
?ia?a?oi??a ia oa?iaeiaeeiai?eo e?ea?nueeeo i?aia?ao?a (nii/aoeo
iioaioe?thaaiiy oa?iaeieia?/ieo aoaeo?a, a iio?i ?o ineaaeaiiy), yeee
aecia/a?oueny oa?i?iii /ano a?ae iiiaioo aaaaeaiiy ?ia?a?oi?a ?
e?ea?nueeiai caniao.

Iieacaii, ui na?aae ?ia?a?oi??a o?eueee oeeiaoeaeei oa oei?aioai?eie
?noioii aaeueioaaee ae?i?iaoe?th aaenaiaeo c i?aai?cio ? i?aeaeuoaaee
eiai oa?iaeieia?/io ae?th. Iii??iee aaeuei?aiee aieea ni?aaeyee
?ioa?oa?ii oa aeeaoeeaeeo?iea?aaiao, ua iaioee — eaoieiiacie oa
o?ai?iaeeoinoao. ?ai?oeaeei ia aieeaaa ia oa?iaeie?iaoeeo oa aoaeo
aaenaiaeo.

Anoaiiaeaii, ui na?aae aei?iaoaaieo ?ia?a?oi??a eeoa eeio?eiacie oa
eaoieiiacie ni?aaeyee a?ae/ooiee aieea ia oa?iaeieia?/iee aoaeo
eaoai?io. Ia aeyaeaii a?ae/ooii? oa?iaeiaeeiai?/ii? ?ioa?oa?aioe??
eaoai?io c oeeiaoeaeeiii, ?ai?oeaeeiii, oei?aioai?eieii,
aeeaoeeaeeo?iea?aaiaoii, eiaaeueoo oei?eaeii oa o?ai?iaeeoinoaoii.

Na?aae ?ia?a?oi??a a iaea?eueo?e i??? iioaioe?thaaee oa?iaeieia?/iee
aoaeo ?iaeiiaoaoeeio — oeeiaoeaeei, o?ai?iaeeoinoao oa eiaaeueoo
oei?eae. Iaioei aeyaeany aieea oei?aioai?eieo oa ?ioa?oa?iio, iacia/iei
– aeeaoeeaeeo?iea?aaiaoo oa ?ai?oeaeeio.

Ee?i?/ia cia/aiiy aeyaeaieo caeiiii??iinoae aieeao ?ia?a?oi??a ia
oa?iaeie?iaoeeo oa oa?iaeieia?/io aeoeai?noue aianoaoee?a oa
aiaeueaaoee?a iieyaa? a iiaeeeaino? i?iaiicoaaiiy iane?aee?a
oa?iaeie?iaoe/ii? oa oa?iaeiaeeiai?/ii? ?ioa?oa?aioe?? aea/aieo
i?aia?ao?a c ?ioeie e?ea?nueeeie caniaaie, ui iathoue aeanoeaino?
?ia?a?oi??a oeeoio?iio ?-450. E??i oeueiai io?eiai? ?acoeueoaoe iiaeooue
neoaeeoe iaoeiai-oai?aoe/iei i?aea?oioyi aeey ?ic?iaee iiaeo i?aeoiae?a
aei oe?eani?yiiaaii? ei?aeoe?? oa?iaeieia?/ii? aeoeaiino? e?ea?nueeeo
cania?a.

Iniiaii iieiaeaiiy aeena?oaoei? ai?iaaaeaeaii a iaa/aeueiee i?ioean
eaoaae? oa?iaeieiai? oa aiioiii? Aiiieoeueeiai aea?aeaaiiai iaaee/iiai
oiiaa?neoaoo ii. I.I.Ie?iaiaa, Oa?iii?euenueei? iaaee/ii? aeaaeai??,
aeei?enoiaothoueny a i?iaaaeaiii naiiia?nueeeo caiyoue c? nooaeaioaie.

Iniaenoee aianie caeiaoaa/a.

Iniiai? ?acoeueoaoe aeine?aeaeaiiy, ye? aeeeaaeai? a aeena?oaoe??
io?eiai? iniaenoi caeiaoaa/ai. Ieaioaaiiy aoai?a aeine?aeaeaiiy, iae?e,
aiae?c ia?aeiiiai iaoa??yeo, noaoenoe/ia ia?iaea ?acoeueoao?a, ?ic?iaea
iniiaieo iieiaeaiue oa aeniiae?a aeeiiai? aeena?oaioii iniaenoi. Iaoiae
aecia/aiiy ?iaeiiaoaoeeio a a?ieia?/iiio iaoa??ye? ?ic?iaeaii ?acii c
ae.i.i. I.A.Noai?neaa/oeii oa anenoaioii eaoaae?e oaeoeueoaonueei?
oa?ai?? I.?.Inoai/oe. Aeena?oaioii a?aee?eoi eieuei?iao ?aaeoe?th
?iaeiiaoaoeeio c ia?a-aeeiaoeeai?iiaaicaeueaeaa?aeii ? ?ic?iaeaii oiiae
?? aeei?enoaiiy aeey e?euee?niiai aecia/aiiy ?iaeiiaoaoeeio a
e?ea?nueeeo oi?iao.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iniiaii iaoa?iyee aeena?oaoei? aeiiiaiaeaeenue oa iiaeaaaeenue ia
I?aeia?iaei?e eiioa?aioe?? “Eeeie/aneay oa?iaeieiaey — 25 eao” (Iineaa,
1997), 2-?e Oe?a?inueeie iaoeiaie eiioa?aioei? ca o/anoth e?a?i NIAe
“Aeooaeueii i?iaeaie eeiii/ii? oa?iaeieiai?” (Aiiieoey, 1998), ia
?anioae?eainueeiio neiiiceoi?, ia iaoeiai-i?aeoe/i?e eiioa?aioe??, ia
caniaeaiiyo iaeanieo iaoeiaeo oiaa?enoa a?io?i?e?a oa oa?iaeieia?a.

Ioae?eaoe??.

?acoeueoaoe ?iaioe iioae?eiaaii o 4 noaooyo o iaoeiaeo aeo?iaeao ? 3
iaoa??yeao iaoeiaeo c’?cae?a oa eiioa?aioe?e ??ciiai ??aiy.

No?oeoo?a oa ianya aeena?oaoei?.

Aeena?oaoeiy neeaaea?oueny ci anooio, iaeyaeo eioa?aoo?e, aeaae
“Iaoa?iyee oa iaoiaee” 3 aeaa aeanieo aeineiaeaeaiue, iaaiai?aiiy,
aeniiaeia oa iieaae/eea oeeoiaaii? eioa?aoo?e, yeee iinoeoue 360
aeaea?aea aio/eciyieo oa ca?oaiaeieo ioaeieaoeie. Aeena?oaoeiy
aeeeaaeaia ia 216 noi?iieao iaoeiiieniiai oaenoo, i?noeoue 51 oaaeeoeue,
32 ?enoie?a i 1 noaio.

CIINO ?IAIOE

Iaoa?iye, iiaeaei oa iaoiaee aeineiaeaeaiiy. Aeineiaeaeaiiy aeeiiaii ia
uo?ao-naioeyo iiioeyoei? Ainoa? (834) ianith 120-250 a. I?ae /an
aenia?eiaio?a oaa?eie ia?aaoaaee ia ?aoe?ii?, ui caaacia/o?
iaaeoiaeaeaiiy ii?iaeueieo e?eueeinoae iacai?iieo ioo???io?a.

Iiaeaeeth iioeeoeaioe?? c ia?aaaaeii i?inoaaeaiaeeiiaeie iaoai?ciaie
oi?ioaaiiy aieueiai? ?aaeoe?? neoaeea aae’thaaioiee a?o?eo uo??a. Iiaiee
aae’thaaio O?aeiaea (2 /anoeie aacaeiio, iaeia /anoeia eaiieiio oa aaeoa
aaeoeeia AOeAE c ?ic?aooieo 5 ia/ie) aaiaeeee iiae ieaioa?iee aiiiaa?ic
caaeiuei? eaie uo?a a ia’?ii 0,1 ie. Aae’thaaioiee a?o?eo ?icaeaa?oueny
o 80-90% oaa?ei /a?ac 10-14 aeiia iiney aaaaeaiiy aae’thaaioa. Ii?ia
iioeeoeaioeaii? ?aaeoei? o aiaeiiaiaeue ia iaoaii/ia iiae?aciaiiy
aea/aee ia noaeiaao, o?aaeaieo aae’thaaioiei a?o?eoii (O.I.O?eion,
1975). A iniiao iaoiaeo iieeaaeaii i?eioeei iaoaii/iiai noeneaiiy
eiioeiaee aeanoe/iei aeaooii. Nooiiiue oeneo ?a?no?o?oueny ca
niaoeiaeueiith oeaeith aeaeiaaeaiiy aeaooa.

Iiaeaeeth iioeeoeaioe?? c ia?aaaaeii oeaio?aeueieie iaoai?ciaie
oi?ioaaiiy iioeeoeaioeaii? ?aaeoe?? neoaeeea iiaeaeue oa?i?/iiai
iiae?aciaiiy. A ?iei oa?ii/iiai iiae?acieea aeei?enoiaoaaee aiaeyio
aaith c oaiia?aoo?ith 580 N. Ii?ia iioeeoeaioeaii? ?aaeoei? ioeiithaaee
ca o?eaaeinoth eaoaioiiai ia?iiaeo aiaenieeoaaiiy oainoa.

?iaeoeoe?th oa?iaio?a iaoaaie?cio enaiia?ioee?a aeeeeeaee aaaaeaiiyi
?yaeo ?ciaiceiniaoeeo?/ieo oa ianaeaeoeaieo ?iaeoeoi??a — aaici??aio,
oaiiaa?a?oaeo, aeaenaiaoaciio, ??oaii?oeeio oa aoeaoiio.

Aaici??ai aaiaeeee aioo??oiueii/a?aaeiii o aeaeyae? ianeyiiai ?ic/eio a
aeic? 25 ia/ea, iaeei ?ac ia aeiao, i?ioyaii 4-o aei?a. Oaiiaa?a?oae o
aeaeyae? aiaeiiai ?ic/eio eiai iao???ai? nie? aaiaeeee
aioo??oiueii/a?aaeiii a aeic? 70 ia/ea, iaeei ?ac ia aeiao, i?ioyaii 5
aei?a. Aeaenaiaoacii aaiaeeee i?aeoe??ii a aeic? 5 ia/ea, iaeei ?ac ia
aeiao, i?ioyaii 5 aei?a. ??oaii?oeei aaiaeeee o aeaeyae? e?ioiaeueii?
noniaic?? aioo??oiueioeoieiai a aeic? 100 ia/ea, iaeei ?ac ia aeaiue,
i?ioyaii 5 aei?a. Aoeaoii aaiaeeee a oeoiie o aeaeyae? 30% ?ic/eio ia
0,9% ?ic/ei? iao??th oei?eaeo a aeic? 2 ie/ea, iaeei ?ac ia aeiao,
i?ioyaii 3-o aei?a.

A aeine?ae oaa?ei a?aee /a?ac 48 aiaeei i?ney inoaiiueiai aaaaeaiiy
oaiiaa?a?oaeo oa aaici??aio oa /a?ac aeiao i?ney inoaiiueiai aaaaeaiiy
?ioeo ?iaeoeoi??a.

Iiaeaeue ?ia?aoaaiiy i?e?iniiaeueieo oa?iaio?a aeeeeeaee aaaaeaiiyi
oaa?eiai ?ia?a?oi??a ??cieo oa?iaeieia?/ieo a?oi. Aeieaoi?e
I2-?aoeaioi??a a?noai?io — oeeiaoeaeei oa ?ai?oeaeei uo?ai aaiaeeee
aioo??oiueioeoieiai a aeicao 100 ia/ea, iaeei ?ac ia aeiao, i?ioyaii 5
aei?a. Oei?aioai?eie (eaaii?oeaoei) aaiaeeee ia?i?aeueii a aeic? 100
ia/ea, iaeei ?ac a aeaiue, i?ioyaii 5 aei?a. Eaoieiiacie oaa?eiai
aaiaeeee a aeic? 150 ia/ea, iaeei ?ac ia aeiao, i?ioyaii 4 aei?a, a
oeoiie. Aeeaoeeaeeo?iea?aaiao aaiaeeee a aeic? 200 ia/ea
aioo??oiueioeoieiai, iaeei ?ac ia aeiao, i?ioyaii 2 aei?a.
?aeiia?iaioiee i?aia?ao 2-?ioa?oa?iio (?aaoa?ii) aaiaeeee i?ae oe??o a
aeic? 1 iei iaeeieoeue/ea, iaeei ?ac ia aeaiue, i?ioyaii 3 aei?a.
Eiaaeueoo oei?eae aaiaeeee i?ae oe??o a aeic? 20 ia/ea, iaeei ?ac ia
aeaiue, c ?ioa?aaeii a 2 aei?, aea?/?. O?ai?iaeeoinoao (oa?iaeiiaeiee
i?aia?ao eiea?aieneeaca) aaiaeeee aioo??oiueii/a?aaeiii a aeic? 10
ia/ea, iaeei ?ac ia aeaiue, i?ioyaii 6 aei?a.

Oaa?ei a aeine?ae a?aee /a?ac 2-3 aiaeeie i?ney inoaiiueiai aaaaeaiiy
?ia?a?oi??a, eiee aiie noai?ththoue iaeneiaeueiee aaeuei?aiee aieea ia
oa?iaioe. A aeine?aeao c canoinoaaiiyi eiaaeueoo oei?eaeo uo??a aeey
aeine?aeaeaiiy aeei?enoiaoaaee /a?ac aeiao i?ney inoaiiueiai aaaaeaiiy
?ia?a?oi?a.

Oa?iaeieia?/iee aoaeo aianoaoee?a ioe?ithaaee ca o?eaae?noth eaoaioiiai
ia??iaeo oa aieiaiai iieiaeaiiy uo??a i?ney aaaaeaiiy aaenaiaeo /e
eaoai?io.

Eiiaoeeo aeaiaoeethaaiiy aea/aee ia iie?iniiiie o?aeoei? ia/iiee uo?ia,
yeo aeaeieyee caaaeueiii?eeiyoei niiniaii (E.E.Ea?oceia, A.E.A?/aeia,
1977). *enoioo o?aeoei? oanooaaee ca ia?ea?ieie oa?iaioaie iioioiiae?ie,
eicinii, ieaciaoe/ieo iaia?ai oa iie?inii. Aeoeaiinoue
iioioiiae?iaeueii? aeooaiaoaeaaiae?iaaiace (EO 1.4.1.2) ioeiithaaee ca
?aaeoei?th aiaeiiaethaaeueiiai aiiioaaiiy aeueoa-eaoiaeooa?iai? eeneioe,
a eenei? oinoaoace eicinii (EO 3.1.3.2) oa aetheici-6-oinoaoace iie?inii
(EO 3.1.3.9) ca eieueeinoth iai?aaii/iiai oinoaoo, ui caieueith?oueny
i?e aiae?ieici aiaeiiaiaeiiai noano?aoo — aaoa-aeioea?ioinoaoo, /e
aetheici-6-oinoaoo (A.A.Iie?ianeee, A.E.A?/aeia, 1968). 5-ioeeaioeaeaco
(EO 3.1.3.5) ieaciaoe/ieo iaia?ai aecia/aee ca ooai?aiiyi iai?aaii/iiai
oinoaoo i?e aiae?ieici AI? (E.Ae.Iaino?iaa, ?.C.Noiniai, 1973). Aieie a
iie?iniiiie o?aeoei? aecia/aee iie?iaio?aoiaei iaoiaeii (A.A.Ei/aoia,
1980).

Aeineiaeaeaiiy i?iaaaeaii c i’youeia noano?aoaie aeaiaoeeace —
aiiaeiii?eiii, eaoai?iii, iiaeiiaoaoeeiii, a?eo?ii?oeeiii oa
iaoai?ieieii. Aeaiaoeeacio aeoeaiinoue aecia/aee ye iienaii ?aiioa
(E.E.Ea?oceia, A.E.A?/aeia, 1977) ca eieueeinoth ooai?aiiai
oi?iaeueaeaaiaeo i?e oieniaaiiio /ani iieoaaoei? (5 oa. aeey
ai?aeii??eio oa eaoai?io ? 30 oa. aeey ?iaeiiaoaoeeio oa ?ioeo
noano?ao?a).

Aoeaoai?e?ae- oa ai?e?ia?ae?ieneeacio aeoeai?noue aecia/aee ca
ooai?aiiyi ia?a-ai?iioaiieo (E.E.Ea?oceia, A.E.A?/aeia, 1977), a
ia?a-i?o?ioaiiea?ae?ieneeacio aeoeai?noue ca ooai?aiiyi
ia?a-i?o?ieaoaoieo (G.Liu et al., 1991).

Aeoeai?noue aaeniaa?a?oaea?ae?ieneeace ioe?ithaaee aeei?enoiaoth/e
?ieoaaoe?eia na?aaeiaeua iienaia ?.?.Ea?oc?iith oa A.?.A?/aeiaei (1977).
E?euee?noue 3-a?ae?ieneaaeniaa?a?oaeo aecia/aee iaoiaeii oiieioa?iai?
o?iiaoia?ao?? (U.Breyer, D.Villumsen, 1975) i?ney eiai aeno?aeoe?? c
?ieoaaoe?eii? noi?o? oei?ioi?iii. Ai?no aaenaiaeo a ieaci? e?ia? oa
i?aaiao uo??a ioe?ithaaee niaeo?ioioiiao?e/iei iaoiaeii ca eiai
iiaeeiaiiyi i?e 245 ii i?ney aeae?eaiiy iaoiaeii oiieioa?iai?
o?iiaoia?ao?? (U.Breyer, D.Villumsen, 1975).

Eiioeaio?aoeith iiaeiiaoaoeeio, a ieacii e?iai aecia/aee ca aeiiiiiaith
?ic?iaeaiiai iaie iaoiaeo, yeee a?oioo?oueny ia eieuei?ia?e ?aaeoe??
?iaeiiaoaoeeio c ia?a-aeeiaoeeai?iiaaicaeueaeaa?aeii (i-AeIAAA) a
eiioeaio?iaai?e n??/ai?e eeneio?. Aeey aeae?eaiiy iaiaoaaie?ciaaiiai
i?aia?aoo canoinoaaee iaoiae oiieioa?iai? o?iiaoia?ao??. Oea aeicaieeei
ie?aii aecia/aoe eiioeaio?aoe?th a ieaci? e?ia? iaci?iaio oi?io
?iaeiiaoaoeeio.

Iaci?iaio oi?io ai?aeii??eio a?ae eiai iaoaaie?o?a a?aeae?eyee iaoiaeii
oiieioa?iai? o?iiaoia?ao??, i?ney aeno?aeoe?? c ieacie e?ia? oei?ioi?iii
(Breyer-Pfaff U. et al., 1982). Aeae?eaiee ai?aeii??ei e?euee?nii
aecia/aee i?e 265 ii (Sistovaris N. et al., 1983).

Ia?aiao?e oa?iaeieiiaoeee i?aia?aoo ?ic?aoiaoaaee ca aeiiiiiaith
aeaio/anoeiii? iiaeaei c o?aooaaiiyi aniieooaaiiy (A.I.Nieiaueaa e
niaao., 1980; E.A.Oieiaeia, A.I.sseiaeaa, 1985; A.E.Ieio?ianeee, I.Aaen,
1988).

Noaoenoe/io ia?iaeo ?acoeueoaoia aeineiaeaeaiiy aeeiioaaee iaoiaeaie
aiiiao?i? (A.A.Aoaea?, 1978, A.I.Iineia, 1990).

?ACOEUeOAOE ?IAIOE OA ?O IAAIAI?AIIss

Ia ia?oiio aoai? aoei aea/aii iniaeeaino? ooieoe?iioaaiiy iniiaieo
oa?iaio?a a?io?ainoi?iaoe?? aaenaiaeo (aaeniaa?a?oaea?ae?ieneeace),
eaoai?io (eaoai?i-N-aeaiaoeeace), ?iaeiiaoaoeeio
(?iaeiiaoaoeei-I-aeaiaoeeace) oa iiaeaeueiiai i?aia?aoo — aiaeueaaoeea
ai?aeii??eio (ai?aeii??ei-N-aeaiaoeeace) a oiiaao iiaeoeyoe?? aeoeaiino?
oeeoio?iio ?-450. Aeine?aee i?iaaaeaii c oe?eei ?yaeii ?iaeoeoi??a oa
?ia?a?oi??a, /anoeia c yeeo i?iyaey? iaaio naeaeoeai?noue uiaei ie?aieo
?cioi?i oeeoio?iio ?-450. A?eueo?noue c iiaeeo?eaoi??a neeaee e?ea?nuee?
i?aia?aoe (oeeiaoeaeei, ?ai?oeaeei, oei?aioai?eie, ?ioa?oa?ii,
eaoieiiacie, eeio?eiacie, o?ai?iaeeoinoao, oaiiaa?a?oae, aeaenaiaoacii,
??oaii?oeei). Aaeuei?aiee aieea ?ia?a?oi??a ii??aithaaany c eeane/iei
?ia?a?oi?ii — eiaaeueoo oei?eaeii.

Iaie anoaiiaeaii (oaae. 1), ui ?ia?a?oi?e a iaiaeiaeia?e i???
iiaeeo?eoaaee aeine?aeaeoaai? oa?iaioaoeai? aeoeaiino?, i?e/iio
a?aei?iiino? noinoaaeenue ?ia?a?oi??a c iaaiith naeaeoeai?noth
aaeuei?aii? ae??. Iaaea??eiaee ?ia?a?oi? — eiaaeueoo oei?eae ??aiii??ii
(i?eaeecii ia 50%) cieaeoaaa oaeaee?noue N-aeaiaoeethaaiiy eaoai?io oa
ai?aeii??eio, I-aeaiaoeethaaiiy ?iaeiiaoaoeeio oa a?ae?ieneethaaiiy
aaeniaa?a?oaeo, oiae? ye oei?aioai?eie aeoeaii aaeueioaaa eeoa
?iaeiiaoaoeei-I-aeaiaoeeacio aeoeai?noue (aei 30% a?ae eiio?ieth) oa
aaeniaa?a?oaea?ae?ieneeacio aeoeai?noue (aei 28%), i?aeoe/ii ia
ci?ithth/e eaoai?iaeaiaoeeacio aeoeai?noue. A oie aea /an eaoieiiacie,
aeeeeeath/e i?aeoe/ii iiaio aeieaaeo aeaiaoeethaaiiy eaoai?io (aei 19%),
eeoa ia 29% oiia?eueithaaa oaeaee?noue aeaiaoeethaaiiy ?iaeiiaoaoeeio, ?
ua iaioa – aeaiaoeethaaiiy ai?aeii??eio, ui aeaco? ia i?eiaeaaei?noue
oa?iaio?a, iaoaaie?coth/eo eaoai?i oa ?iaeiiaoaoeei aei ??cieo ?cioi?i
oeeoio?iio ?-450. Ine?eueee eaoieiiacie ? naeaeoeaiei ?ia?a?oi?ii
?cioi?i i?ae?iaeeie ?4503A (M.Maurice et al., 1992; M.Bourrie et al.,
1996), iiaeia i?eionoeoe, ui eaoai?iaeaiaoeeacia aeoeai?noue iaeaaeeoue
naia aei oe??? i?ae?iaeeie oeeoio?iio.

??ciith aeyaeeanue /ooeea?noue aeine?aeaeoaaieo oa?iaioaoeaieo
aeoeaiinoae ? aei aieeao canoiniaaieo ?iaeoeoi??a. Cie?aia,
ianiaoeeo?/i? ?iaeoeoi?e oaiiaa?a?oae oa ??oaii?oeei ?noioii
ca?eueooaaee on? aeoeaiino?, oiae? ye i?aeoe/ii ia aoei aeyaeaii
?iaeoeoth/iai aieeao aaici??aio oa aoeaoiio — ?iaeoeoi??a c iaaiith
naeaeoeai?noth aei oeeoio?ii?a i?ae?iaeei 1A oa 2A, a?aeiia?aeii
(D.Lucas et al., 1990; Donato M., 1995; C.Lieber, 1997), ui aeaco? ia
iai?e/aoi?noue aeacaieo ?cioi?i aei aeine?aeaeoaaieo oa?iaioaoeaieo
aeoeaiinoae. I?ae aieeaii aeaenaiaoaciio aea??eiai ca?eueooaaeanue
oaeaee?noue aeaiaoeethaaiiy eaoai?io. Oaea aea??eia?noue uiaei
aeaenaiaoaciio, ? iciaeith iiae-

Oaaeeoey 1

Aieea ?iaeoeoi??a oa ?ia?a?oi??a aeoeaiino? oeeoio?iio ?-450 ia ?aaeoe??
a?io?ainoi?iaoe?? ai?aeii??eio, ?iaeiiaoaoeeio, eaoai?io oa
aaeniaa?a?oaeo a i?e?iniii?e o?aeoe?? ia/?iee uo??a (na?aaei? aaee/eie c
8-10 niinoa?aaeaiue, M±m)

Iiaeeo?eoth/ee i?aia?aoAi?aeii??ei-N-aeaiaoeeaca
(iiieue/ia/oa)?iaeiiaoaoeei- I-aeaiaoeeaca
(iiieue/ia/oa)Eaoai?i-N-aeaiaoeeaca
(iiieue/ia/oa)Aaeniaa?a?oae-a?ae?ieneeaca
(iiieue/ia/oa)Eiio?ieue5,62±0,420,42±0,0484,70±0,282,83±0,14?IA?A?OI?EOe
eiaoeaeei1,74±0,19*0,15±0,020*3,97±0,561,18±0,056*% aei
eiio?ieth30338440?ai?oeaeei5,18±0,390,42±0,0264,18±0,302,55±0,189% aei
eiio?ieth89938887Oei?aioai?eie2,77±0,20*0,14±0,018*3,95±0,260,81±0,10*%
aei
eiio?ieth48318328Eaoieiiacie4,78±0,24*0,32±0,020*0,88±0,11*2,07±0,13*%
aei eiio?ieth82711971AeAAeOE3,91±0,19*0,30±0,022*4,02±0,242,01±0,15*%
aei eiio?ieth67678569Eiaaeueoo
oei?eae2,98±0,17*0,23±0,013*2,00±0,17*1,50±0,057*% aei
eiio?ieth51514251OAeO3,64±0,30*0,23±0,033*4,00±0,191,89±0,18*% aei
eiio?ieth62518464?IAeOEOI?EAaici??ai6,31±0,410,48±0,0325,27±0,453,16±0,2
2% aei
eiio?ieth112114112112Oaiiaa?a?oae16,49±1,64*0,74±0,041*9,84±0,91*7,32±0,
86*% aei
eiio?ieth293176209259Aoeaoii7,77±0,68*0,53±0,0406,25±0,54*3,20±0,22% aei
eiio?ieth138126133113Aeaenaiaoacii9,63±1,17*0,62±0,077*10,97±1,22*3,96±0
,23*% aei
eiio?ieth171147233138??oaii?oeei8,42±1,05*0,74±0,065*9,20±0,43*5,83±0,63
*% aei eiio?ieth150176196206I?ei?oea: “*” — a??ia?aeia ??cieoey c
a?oiith “Eiio?ieue”.

eeai? i?eiaeaaeiino? eaoai?iaeaiaoeeace aei i?ae?iaeeie ?-4503A,
ine?eueee aeaenaiaoacii a?aeiinii naeaeoeaii ?iaeoeo? naia oeth ?cioi?io
(K.Debri et al., 1995).

Aoa aea/aiee ei?aeyoe?eiee ca’ycie i?ae ia?ea?ieie aeoeaiinoyie ie?aieo
?cioi?i oeeoio?iio ?-450 (aaeniaa?a?oaea?ae?ieneeaca,
ai?aeii??eiaeaiaoeeaca, a?eo?ii?oeeiaeaiaoeeaca, iaoii?ieieaeaiaoeeaca)
oa eaoai?i-N-aeaiaoeeaciith ? ?iaeiiaoaoeei-I-aeaiaoeeaciith
aeoeaiinoyie. Anoaiiaeaii, ui oaeaee?noue aeaiaoeethaaiiy eaoai?io
i?e?iniiiith o?aeoe??th ia/?iee iaeo?ni?oa ei?aeth? c
a?eo?ii?oeeiaeaiaoeeaciith aeoeai?noth (r=0,66) ? i?aeoe/ii ia ei?aeth?
c ia?ea?aie ?ioeo ?cioi?i oeeoio?iio ?-450. Ine?eueee aeaiaoeethaaiiy
a?eo?ii?oe?io, ye a?aeiii, ? ia?ea?ii oa?iaio?a ?iaeeie ?4503A
(M.Carelli et al., 1996; H.Wang et al., 1996), oi, i/aaeaeii, ?
eaoai?i-N-aeaiaoeeacia aeoeai?noue oaeiae iaeaaeeoue aei oe??? ?iaeeie
oeeoio?iio ?-450. Iaeii/anii niinoa??aaee o?nio noi?yaeai?noue
?iaeiiaoaoeei-I-aeaiaoeeacii? aeoeaiino? c ia?ea?ii i?ae?iaeeie ?4502N
aaeniaa?a?oaea?ae?ieneeacith (r=0,89). Oea ? aeineoue aaaiiith iciaeith
oiai, ui ?aaeoe?y I-aeaiaoeethaaiiy ?iaeiiaoaoeeio eaoae?co?oueny
oa?iaioaie i?ae?iaeeie oeeoio?iio ?4502N.

A ianooii?e /anoei? aeine?aeaeaiiy iaie i?ine?aeeiaaii e?iaoeeo
aeaiaoeethaaiiy eaoai?io, ?iaeiiaoaoeeio oa ai?aeii??eio a oiiaao ae??
?ia?a?oi??a. Aoei iieacaii, ui aeaiaoeethaaiiy oeeo noano?ao?a
cae?enith?oueny iaeiioa?iaioiith nenoaiith aac yaeu eiiia?aoeaiino?,
ine?eueee e?iaoeea ?aaeoe?e iiai?noth i?aeei?y?oueny caeiio
I?oaae?na-Iaioai. Na?ae/aiiyi oeueiio ? ni?yieaiiy e?eaeo “oaeaee?noue
?aaeoe?? — eiioeaio?aoe?y noano?aoo” i?e ia?aaaaeaii? a eii?aeeiaoe
Eaeio?aa?a-Aa?ea. Iaie anoaiiaeaii oei aaeueioaaiiy — a?eueo?noue
?ia?a?oi??a ni?aaeyee na?e aaeuei?aiee aieea ia ?aaeoe?? aeaiaoeethaaiiy
ii ci?oaiiio oeio.

Ciaeaeai? iaie ?N50 aeey aeine?aeaeaieo ?ia?a?oi??a aeyaeeenue ??cieie
noiniaii eaoai?io, ?iaeiiaoaoeeio oa ai?aeii??eio (oaae. 2).
?ai?oeaeei ia

Oaaeeoey 2

?N50 (iI) aeey ?ia?a?oi??a a caeaaeiino? a?ae noano?aoo aeaiaoeeace

? i a ? a ? o i ? eAi?aeii??ei-N-
aeaiaoeeaca?iaeiiaoaoeei-I-aeaiaoeeacaEaoai?i-N-
aeaiaoeeaca?ai?oeaeei555Oeeiaoeaeei0,20,125Oei?aioai?eie0,0540,0922,03Ee
io?eiacie0,3050,3500,095O?ai?iaeeoinoao0,270,0492

i?iyaeya ?ia?a?oi?ieo aeanoeainoae iaa?oue a iiey?ieo eiioeaio?aoe?yo,
oiae? ye aeey oeeiaoeaeeio ?N50 noiniaii ?aaeoe?e aeaiaoeethaaiiy
ai?aeii??eio oa ?iaeiiaoaoeeio aoea a iaaeao 0,1-0,2 iI. Iaeiae,
iaa?oue aenie? eiioeaio?aoe?? oeeiaoeaeeio ia aeeeeeaee aaeueioaaiiy
?aaeoe?? aeaiaoeethaaiiy eaoai?io. Oei?aioai?eie ?ioaineai?oa aaeueioaaa
aeaiaoeethaaiiy ai?aeii??eio, o?ioe neaae?oa — ?iaeiiaoaoeeio ? cian?i
ia ae?ya ia eaoai?iaeaiaoeeacio aeoeai?noue, oiae? ye eeio?eiacie
aeyaeany a?aeiinii naeaeoeaiei ?ia?a?oi?ii ?aaeoe?? aeaiaoeethaaiiy
eaoai?io (?N50 aoea iaeieae/ith — 0,095 iI).

Oaeei /eiii, iaaaaeai? ?acoeueoaoe aeaiiino?othoue ?ciaiceiniaoeeo?/iee
oa?aeoa? aaeuei?aii? ae?? ?ia?a?oi??a ? ni?iiiaei?noue inoaii?o ?noioii
iiaeeo?eoaaoe a?io?ainoi?iaoe?th e?ea?nueeeo i?aia?ao?a. Iane?eueee oeae
aieea ? ?noioi?i aeey eiai ?aae?caoe?? ia oa?iaeie?iaoe/iiio oa
oa?iaeiaeeiai?/iiio ??ai? aoei aeine?aeaeaii a ianooii?e /anoei? ?iaioe.

Iaie aea/aii aieea ?ia?a?oi??a ia oa?iaeie?iaoeeo oa oa?iaeieia?/iee
aoaeo aaenaiaeo, ?iaeiiaoaoeeio oa ai?aeii??eio. Aeyaeeinue, ui
canoiniaai? ?a?a?oi?e ii ??ciiio aieeaaee ia oa?iaeie?iaoeeo aaenaiaeo
(oaae. 3). Iaeneiaeueiee iiaeeo?eoth/ee aieea ni?aaeya oei?aioai?eie.
Oaiaeaioe?y aei i?aeaeuaiiy ??aiy iaci?iaii? oi?ie aaenaiaeo a ieaci?
e?ia? uo??a i?ae aieeaii oei?aioai?eieo i?iyaeyeanue c 10-? oaeeeie
aenia?eiaioo, a ia 20-o oaeeeio aeine?aeo ?a?no?oaaeinue a??ia?aeia
ca?eueoaiiy eiioeaio?aoe?? aaenaiaeo. Ae?aci?noue ci?i ia?inoaea a /an?
aei e?ioey aenia?eiaioo (100 oa). Aeecueeeie aei oei?aioai?eieo, aea
aeaui iaioeie, aeyaeeenue iiaeeo?eoth/? aoaeoe eiaaeueoo oei?eaeo oa
oeeiaoeaeeio. I?ae aieeaii oeeo ?ia?a?oi??a aeinoia??ii
oiia?eueithaaeinue aeaaaeaiiy aaenaiaeo c i?aai?cio. Eiioeaio?aoe??
aaena-

Oaaeeoey 3

Aieea ?ia?a?oi??a ia aeeiai?eo eiioeaio?aoe?? (iea/ie) aaenaiaeo a
ieaci? e?ia? uo??a i?ney aioo??oiueii/a?aaeiiiai aaaaeaiiy a aeic? 75
ia/ea

?ia?a?oi?e*an i?ney aaaaeaiiy aaenaiaeo
(oa)20406080100Eiio?ieue29,7±2,3017,0±0,7810,8±0,706,8±0,284,4±0,25Oeeia
oeaeei38,2±2,07*25,2±0,84*16,5±0,73*11,5±0,53*7,8±0,25*?ai?oeaeei27,7±2,
9217,4±1,3710,9±0,817,3±0,534,7±0,48Oei?aioai?eie39,9±1,74*27,5±1,37*19,
3±1,21*13,3±0,59*8,8±0,39*AeAAeOE
36,0±2,6620,3±1,2613,2±0,73*8,7±0,34*5,9±0,31*Eaoieiiacie32,2±1,9118,3±1
,1211,9±1,077,5±0,225,1±0,17*Eiaaeueoo
oei?eae38,6±3,5025,1±1,18*17,3±0,59*11,7±0,42*7,9±0,34*OAeO
31,7±2,4918,1±1,2611,8±0,627,9±0,34*5,4±0,28*I?ei?oea: “*” — aeinoia??i?
a?aei?iiino? uiaei a?oie “eiio?ieue”.

iaeo a ieaci? e?ia? oaa?ei, ye? io?eioaaee aeacai? ?ia?a?oi?e cia/ii
ia?aaeuoaaee oae? o oaa?ei eiio?ieueii? a?oie. Cia/ii iaioei aoa aoaeo
aeeaoeeaeeo?iea?aaiaoo, i?ioa ? a oeueiio aeiaaeeo, ii/eiath/e c 60-?
oaeeeie ??cieoey c eiio?ieai aoea aeinoia??iith. Eeoa ia ??ai?
oaiaeaioe?? i?ioyaii o?eaaeiai /ano aoa iiaeeo?eoth/ee aoaeo
o?ai?iaeeoinoaoo oa eaoieiiacieo. Cian?i ia aieeaaa ia eiioeaio?aoe?th
aaenaiaeo a ieaci? e?ia? oaa?ei ?ai?oeaeei.

?ic?aooiee ia?aiao??a oa?iaeie?iaoeee aaenaiaeo iieacaee, ui oi/eith
i?eeeaaeaiiy iiaeeo?eoth/iai aieeao ?ia?a?oi??a ? i?ioeane aeaaaeaiiy,
ine?eueee caciaaaee iae?noioi?oeo ci?i naia o? oa?iaeie?iaoe/i?
ia?aiao?e, ye? a?aeia?aaeathoue ae?i?iaoe?th i?aia?aoo c i?aai?cio —
ia??iae iai?aaeaaaeaiiy a -oaco (T1/2), ieiua i?ae oa?iaeie?iaoe/iith
e?eaith (AUC), na?aaei?e /an oo?eiaiiy i?aia?aoo a i?aai?ci? (MRT) oa
ee??ain (Cl). Iaea?eueo? ci?ie aeacaieo iieaciee?a niinoa??aaee a a?oi?
oaa?ei, ye? io?eioaaee oei?aioai?eie. Oae, T1/2 aaenaiaeo c?inoaa a?eueo
ye o 3 ?ace, AUC ca?eueooaaeanue a 1,6 ?ace, a MRT — a 1,7 ?ace. A 2,6
?ace i?aeaeuoaaany T1/2 aaenaiaeo i?ae aieeaii oeeiaoeaeeio. Aeaui
iaioei aoa aieea eiaaeueoo oei?eaeo. Aaaaeaiiy oaa?eiai OAeO,
aeeaoeeaeeo?iea?aaiaoo /e eaoieiiacieo a?aeiinii iaei aieeaaei ia
i?ioeane ae?i?iaoe?? aaenaiaeo c ieacie e?ia? uo??a.

Oa?iaeie?iaoe/ia ?ioa?oa?aioe?y i?ae aaenaiieii oa ?ia?a?oi?aie
a?aeia?aceeanue ? ia ??ai? oa?iaeieia?/iiai aoaeoo (oaae.4).
Iaeneiaeueii (a 2,1 ?ace) o?eaae?noue aaenaiaeiaiai nio c?inoaea o
oaa?ei i?ney iiia?aaeiueiai

Oaaeeoey 4

Aieea ?ia?a?oi??a ia oa?iaeieia?/iee aoaeo aaenaiaeo oa eaoai?io o
uo??a i?ney aioo??oiueii/a?aaeiiiai aaaaeaiiy a aeic? 75 oa 120 ia/ea,

a?aeiia?aeii (M±m, n=10-12)

O?eaae?noue aieiaiai iieiaeaiiy?ia?a?oi?eAaenaiaeEaoai?iNaeoiaee
%Naeoiaee
%Eiio?ieue1431±921001109±80100Oeeiaoeaeei2735±97*1911302±88117?ai?oeaeei
1606±1111121082±8798Oei?aioai?eie2952±115*2061314±91118Aeeaoeeaeeo?iea?a
aiao1998±99*1401219±65110Eaoieiiacie1717±
70*1201880±103*170Eeio?eiacie—2024±119*183Eiaaeueoo
oei?eae2230±104*1561191±67107O?ai?iaeeoinoao1721±83*1201158±61104I?ei?oe
a: Ciaeii “*” iicia/aii a??ia?aeio ??cieoeth o ii??aiyii? c a?oiith
“Eiio?ieue”.

aaaaeaiiy oei?aioai?eieo. I?ae aieeaii oeeiaoeaeeio oaeiae ?noioii
i?aeneethaaany oa?iaeieia?/iee aoaeo aaenaiaeo. O?eaae?noue aieiaiai
iieiaeaiiy o ii??aiyii? c eiio?ieai c?inoaea a 1,9 ?ace. O oaa?ei, ui
iiia?aaeiuei io?eioaaee eiaaeueoo oei?eae o?eaae?noue oa?iaeieia?/iiai
aoaeoo aaenaiaeo c?inoaea a 1,5 ?aca. Aeeaoeeaeeo?iea?aaiao aeeeeeaa
iii??ia i?aeaeuaiiy oa?iaeieia?/ii? ae?? aaenaiaeo. Eeoa ia 20%
i?aeneethaaany aoaeo aaenaiaeo i?e eiai ii?aeiaii? c eaoieiiacieii /e
OAeO.

Cian?i ?ioith aeyaeeanue oa?iaeiaeeiai?/ia aca?iiae?y ?ia?a?oi??a c
eaoai?iii. Iaeneiaeueio iiaeeo?eoth/o aeoeai?noue ni?aaeyee eeio?eiacie
oa eaoieiiacie, i?ae ae??th yeeo cia/ii (a 1,83 ?ace) ca?eueoeeanue
o?eaae?noue eaoai?iiaiai ia?eioe/iiai nio. Uiaei oeeiaoeaeeio oa
oei?aioai?eieo, ye? iaea?eueoa iioaioe?thaaee oa?iaeieia?/iee aoaeo
aaenaiaeo, oi noiniaii eaoai?io ?o aieea aeyaeany i?i?iaeueiei.
Eiaaeueoo oei?eae, OAeO, aeeaoeeaeeo?iea?aaiao, ye ? ?ai?oeaeei, ia
aeyaeyee iiaeeo?eoth/iai aieeao ia oa?iaeieia?/iee aoaeo eaoai?io.

Caciaaaea iiaeeo?eaoe?? i?ae aieeaii ?ia?a?oi??a ? oa?iaeie?iaoeea
ianoa?i?aeiiai i?ioecaiaeueiiai i?aia?aoo ?iaeiiaoaoeeio. Iaeneiaeueii
oiia?eueithaaeanue ae?i?iaoe?y ?iaeiiaoaoeeio c ieacie e?ia? oaa?ei, ye?
iiia?aaeiuei io?eioaaee oeeiaoeaeei. Aeaui iaioei aoa aoaeo eiaaeueoo
oei?eaeo ? i?i?iaeueiei — o?ai?iaeeoinoaoo. A?aeiia?aeii
oa?iaeie?iaoeoe? ci?ithaaany ? oa?iaeieia?/iee (aioeiioeeoeaioeaiee)
aoaeo ?iaeiiaoaoeeio. Iaea?eueoa c?inoaa ii??a iioeeoeaioe?? i?e
ii?aeiaii? c oeeiaoeaeeiii (a 2,1 ?ace), o?ioe iaioa (a 1,9 ?aca)
i?aeaeuoaaa ii??a iioeeoeaioeaiiai iiae?aciaiiy eiaaeueoo oei?eae. ?io?
i?aia?aoe cia/ii iaioa iioaioe?thaaee oa?iaeieia?/iee aoaeo
?iaeiiaoaoeeio.

Iaia?eioe/iee aiaeueaaoee — ai?aeii??ei, oa?iaeie?iaoeea ?
oa?iaeiaeeiai?ea yeiai aeine?aeaeoaaeanue ye iiaeaeueiiai i?aia?aoo c
a?aeiieie oeyoaie a?io?ainoi?iaoe??, i?aeoaa?aeea iieiaeaiiy i?i o?nio
caeaaei?noue oa?iaeieia?/ii? ae?? a?ae iniaeeainoae oa?iaeie?iaoe/ii?
iiaaae?iee. ?ia?a?oi?e, ye? iaea?eueoa oiia?eueithaaee ae?i?iaoe?th
ai?aeii??eio c i?aai?cio (oeeiaoeaeei, oei?aioai?eie oa eiaaeueoo
oei?eae) iaeneiaeueii iioaioe?thaaee ? aioeiioeeoeaioeaiee aoaeo
i?aia?aoo.

Ioaea, aeine?aeaeaiiy aeaiiino?o? iaaio aea??eia?noue aaeuei?aii? ae??
?ia?a?oi??a ia ??ai? oa?iaioieo nenoai, yea a oe?e?niiio i?aai?ci?
o?ainoi?io?oueny a iiaeeo?eaoe?th oa?iaeie?iaoeee e?ea?nueeeo i?aia?ao?a
? ?o oa?iaeieia?/iiai aoaeoo. Iaeiae aeyaeeinue, ui aoaeo ?ia?a?oi??a
aeoaea caeaaeeoue ? a?ae /ano aaaaeaiiy i?aia?aoo. Cie?aia, aoei
anoaiiaeaii, ui i?ioyaii ia?oeo 24 aiae i?ney aaaaeaiiy eeio?eiacieo ia?
i?noea iioaioe?thaaiiy oa?iaeieia?/iiai aoaeoo ai?aeii??eio ? aaenaiaeo,
oiae? ye /a?ac 48 aiae aoaeo ci?ith?oueny ia i?ioeeaaeiee — ia? i?noea
?noioia cieaeaiiy oa?iaeieia?/ii? ae?? i?aia?ao?a. Oiaoi, ?ia?a?oi?
/a?ac 48 aiae i?iyaey? aeanoeaino? ?iaeoeoi?a. Oea aeaco? ia oiiai?noue
iiae?eo ?a/iaei ia ?ia?a?oi?e oa ?iaeoeoi?e. Ana caeaaeeoue a?ae
ianoaaei, a yeeo canoiniao?oueny oie /e ?ioee i?aia?ao.

Oaeei /eiii, i?iaaaeai? aeine?aeaeaiiy i?iaeaiiino?oaaee o?nio
caeaaei?noue oa?iaeieieia?/iiai aoaeoo oe?ei? a?oie e?ea?nueeeo
i?aia?ao?a a?ae iniaeeainoae a?io?ainoi?iaoe?? a i?aai?ci? ?
iiaeeea?noue oe?eani?yiiaaiiai ao?o/aiiy a ?o iaoaaie?/io ?iaeoeaaoe?th,
oa?iaeie?iaoeeo oa oa?iaeiaeeiai?eo.

A E N I I A E E

1. Aaeuei?aiee aoaeo ?ia?a?oi??a i?e?iniiaeueieo iiiiieneaaiac ia
a?io?ainoi?iaoe?th aaenaiaeo, eaoai?io, ?iaeiiaoaoeeio oa ai?aeii??eio
aecia/a?oueny i?eiaeaaei?noth oa?iaio?a, ui iaoaaie?cothoue oe? ?a/iaeie
aei o??? /e ?ioi? ?iaeeie oeeoio?iio ?-450 oa naeaeoeai?noth ae??
?ia?a?oi??a.

2. ?aaeoe?y N-aeaiaoeethaaiiy eaoai?io i?e?iniiaie ia/?iee uo??a
cae?enith?oueny ca o/anoth oa?iaio?a, ui iaeaaeaoue aei i?ae?iaeeie
oeeoio?ii?a ?4503A, ine?eueee eaoai?i-N-aeaiaoeeacia aeoeai?noue o?nii
ei?aeth? c ia?ea?ii oe??? i?ae?iaeeie a?eo?ii?oeei-N-aeaiaoeeacith,
noeioeth?oueny aea??eiaeie ?iaeoeoi?aie ? aaeueio?oueny aea??eiaeie
?ia?a?oi?aie.

3. ?aaeoe?y i?e?iniiaeueiiai I-aeaiaoeethaaiiy ?iaeiiaoaoeeio
eaoae?co?oueny oa?iaioaie, ui iaeaaeaoue aei i?ae?iaeeie oeeoio?ii?a
?4502N, i?i ui na?ae/eoue o?nia ei?aeyoe?y c ia?ea?ii oe??? i?ae?iaeeie
— aaeniaa?a?oaea?ae?ieneeacith ? aieea ia oeth ?aaeoe?th
?ciaiceiniaoeeo?/ieo ?iaeoeoi??a oa ?ia?a?oi??a.

4. Oa?iaeieia?/iee aoaeo aaenaiaeo, eaoai?io, ?iaeiiaoaoeeio oa
ai?aeii??eio aecia/a?oueny oaeaee?noth ?o iaoaaie?/ii? ?iaeoeaaoe?? a
oiae? a?io?ainoi?iaoe?? ? eiioeaio?aoe??th iaci?iaii? oi?ie i?aia?ao?a a
ieaci? e?ia?, a aieea ?ia?a?oi??a ia oa?iaeie?iaoeeo oa oa?iaeieia?/iee
aoaeo oeeo i?aia?ao?a aecia/a?oueny caeaoi?noth ?ia?a?oi??a aaeueioaaoe
iiiiiieneaaiace, ui iaoaaie?cothoue oe? ?a/iaeie.

5. A iaea?eueoee i??? ia?eioe/ia ae?y aaenaiaeo iioaioe?th?oueny
oeeiaoeaeeiii, oei?aioai?eieii, aeaui iaioa eiaaeueoo oei?eaeii,
?ioa?oa?iiii oa aeeaoeeaeeo?iea?aaiaoii, neaaei — eaoieiiacieii,
eeio??iacieii oa o?ai?iaeeoinoaoii, a ?ai?oeaeei ia ci?ith?
oa?iaeiaeeiai?eo aaenaiaeo. Aieea aea/aieo ?ia?a?oi??a ia
oa?iaeieia?/iee aoaeo aaenaiaeo ciaoiaeeoueny o a?aeiia?aeiino? aei ?o
caeaoiino? aaeueioaaoe ae?i?iaoe?th aaenaiaeo c ieacie e?ia? oa ia/?iee
oa ?o aaeuei?aiei iioaioe?aeii uiaei aaeniaa?a?oaea?ae?ieneeacii?
aeoeaiino? ia/?iee.

6. Oeeiaoeaeei, ?ai?oeaeei, oei?aioai?eie, aeeaoeeaeeo?iea?aaiao,
eiaaeueoo oei?eae, o?ai?iaeeoinoao ia aieeaathoue ia o?eaae?noue
ia?eioe/ii? ae?? eaoai?io, oiae? ye eeio??iacie oa eaoieiiacie nooo?ai
iioaioe?ththoue aoaeo oeueiai aianoaoeea, ui ei?aeth? c? caeaoi?noth
cacia/aieo ?ia?a?oi??a i?eai?/oaaoe ?aaeoe?th N-aeaiaoeethaaiiy
eaoai?io.

7. Iaeneiaeueii iioaioe?ththoue aioeiioeeoeaioeaiee aoaeo ?iaeiiaoaoeeio
oa ai?aeii??eio — oeeiaoeaeei, o?ai?iaeeoinoao, eiaaeueoo oei?eae,
oei?aioai?eie oa ?ioa?oa?ii; neaaeei /e iiai?noth a?aenooi?i ? aieea
a?aeiia?aeii aeeaoeeaeeo?iea?aaiaoo oa ?ai?oeaeeio. Iioaioe?thth/ee
aoaeo cacia/aieo ?ia?a?oi??a ni?aiaaea? c aaee/eiith ?o aaeuei?aii? ae??
ia ae?i?iaoe?th aiaeueaaoee?a c ieacie e?ia? oa ?o a?io?ainoi?iaoe?th
i?e?iniiiith o?aeoe??th ia/?iee uo??a.

Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??

1. Iaaea?aeue C.N., Aiae I.A., Iaiothe I.I. ?ia?aoaaiiy ?aaeoe??
i-aeaiaoeethaaiiy oeeiaoeaeeiii oa eiea?aieneeacith ye iiaeeeaee
iaoai?ci iioaioe?thaaiiy oa?iaeieia?/ii? ae?? iai?ienaio oa
?iaeiiaoaoeeio// A?niee Iaoeiaeo Aeine?aeaeaiue.- 1997.- ?4-5.-
N.51-53.

2. Iaaea?aeue C.N. ?aaeoe?y N-aeaiaoeethaaiiy, ye iaoaaie?/ia
aeaoa?i?iaioa oa?iaeiaeeiai?/ii? ?ioa?oa?aioe?? ai?aeii??eio oa eaoai?io
c oeeiaoeaeeiii oa eiea?aieneeacith// Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu.- 1997.- ?5.- N.- 24-30.

3. Noai?neaa/oe I.A., Iaiothe I.I., Ai?oeia A.E., Iaaea?aeue C.N.
Aeoeai?noue aeaiaoeeace a oiiaao ?ia?aoaaiiy oeeiaoeaeeiii, i?oioaiii oa
o?ai?iaeeoinoaoii// Oe?a?inueeee a?io?i?/iee aeo?iae.- 1997.- o. 69,
?2.- N.98-103.

4. Inoai/oe I.?., Noai?neaa/oe I.A., Iaaea?aeue C.N. Aieea
oeeiaoeaeeio, o?ai?iaeeoinoaoo oa oaiiaa?a?oaeo ia oa?iaeie?iaoeeo oa
oa?iaeieia?/iee aoaeo ?iaeiiaoaoeeio o uo??a// A?niee A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.- 1997.- ? 2.- N.28-29.

5. Aiae I.A., Iieany O.I., Iaaeaeaeue C.N. Iiaeeoeeaoeey
oa?iaeieeiaoeee e oa?aiaaoe/aneie aeoeaiinoe iai?ienaia eiaeoeoi?aie e
eiaeaeoi?aie oa?iaioia iaoaaieecia enaiiaeioeeia// Eeeie/aneay
oa?iaeieiaey — 25 eao: Iaoa?eaeu iaaeaeoia?iaeiie eiioa?aioeee. —
Iineaa, 1997. — N. 18.

6. Iaiothe I.I., Iaaea?aeue C.N., Noai?neaa/oe I.A., Eaaeooueei N.A.,
?aoe?ai?einueea I.A. Aieea aeayeeo ?ia?a?oi??a iiiiieneaaiac ia
oa?iaeie?iaoeeo ? oa?iaeieia?/iee aoaeo ?iaeiiaoaoeeio// Iaoa??aee ??
Oe?a?inueei? iaoeiai? eiioa?aioe?? c i?aeia?iaeiith o/anoth “Aeooaeuei?
i?iaeaie ee?i?/ii? oa?iaeieia??”.- A?iieoey.- 1998.- N.195-196.

Iaaeaeaeue C.N. Aeeyiea eiaeaeoi?ia iee?iniiaeueiuo iiiiieceaaiac ia
oa?iaeieeiaoeeo e oa?iaeiaeeiaieeo ioaeaeueiuo aiaeueaaoeeia e
aianoaoeeia .- ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe
ii niaoeeaeueiinoe 14.03.05 — oa?iaeieiaey.- Einoeooo oa?iaeieiaee e
oieneeieiaee, AII Oe?aeiu, Eeaa, 1998.

Aeenna?oaoeey iinayuaia aii?inai acaeiiaeaenoaey iaacaieeaathueo
eaea?noaaiiuo n?aaenoa n eaea?noaaiiuie i?aia?aoaie, iaeaaeathueie
naienoaaie eiaeaeoi?ia iee?iniiaeueio iiiiieneaaiac. Onoaiiaeaii
i?aeiouanoaaiii eciyiceiniaoeeoe/aneee oa?aeoa? acaeiiaeaenoaey
eiaeaeoi?ia n enneaaeiaaiiuie oa?iaioaie iaoaaieecia enaiiaeioeeia.
Iieacaia acaeiinaycue iaaeaeo eioaineaiinoueth i?ioeannia
aeio?aninoi?iaoeee eaea?noaaiiuo i?aia?aoia e eo oa?iaeieiae/aneie
aeoeaiinoueth. Ia i?eia?a eiaeiiaoaoeeia e eaoaieia i?iaeaiiino?e?iaaia
aiciiaeiinoue oeaeaiai?aaeaiiiai aiaoaoaeuenoaa a iaoaaieeci,
oa?iaeieeiaoeeo e oa?iaeiaeeiaieeo ioaeaeueiuo a?oii eaea?noaaiiuo
i?aia?aoia. Iniiaiua iieiaeaiey ?aaiou eniieuecothony i?e i?iaaaeaiee
caiyoee e a eaeoeeiiiii eo?na ia eaoaae?ao oa?iaeieiaee e aeioeiee.

Eeth/aaua neiaa: eiaeaeoi?u, oeeoio?ii ?450, aiaeaaoeee,
acaeiiaeaenoaea, aeio?ainoi?iaoeey, oa?iaeieeiaoeea, oa?iaeiaeeiaieea.

Medvid Z. S. Effect of inhibitors of microsomal monooxigenases on
pharmacokinetics and pharmacodynamics of some analgetics and
anesthetics.- Manuscript.

Thesis for a kandidat’s degree by speciality 14.03.05 — pharmacology.-
The Institute of Pharmacology and Toxicology Academy of Medical Science
of Ukraine, Kyiv, 1998.

The thesis is devoted to the problem of interaction of analgetic with
medicinal preparations possessing the properties microsomal
monooxygenases inhibitors. Mainly isoenzymspecific character of
inhibitors interaction with the investigated metabolic enzymes of
xenobiotics was esteblished. The interrelation between intensity of
processes of drug biotransformation and their pharmacological activity
was shown. On the example of indomethacin and ketamin we have
demonstrated the possibility of a goal-directed interference in
metabolism, pharmacokinetics and and pharmacodynamics of separate groups
of drugs. Main principles of the thesis are used in conducting classes
and in course of lectures at Pharmacology and Biochemistry chairs.

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