1

IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE

?INOEOOO O?C?IEIA?? ?IAI? I.I. AIAIIIEUeOess

IIAeIEssI NA?OEAIA EEEI?AIA

OAeE 616.15+616-018-092-06:546.3/8

AIEEA OEI?ENOEO NIIEOE AAAEEEO IAOAE?A (EAAeI?TH, OAE?TH, NAEIOeTH ?
?OOO?) IA NENOAIO ?AAOEssOe?? AA?AAAOIIAI NOAIO E?IA? ? OEAIEIIEE
O?A?EIIE?C

(aenia?eiaioaeueia aeine?aeaeaiiy)

14.03.04 — iaoieia?/ia o?c?ieia?y

AAOI?AOA?AOaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

Ee?a – 1999 ?.

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai??

Iaoeiaee ea??aiee: aeieoi? a?ieia?/ieo iaoe, i?ioani?

Ieneeoeueeee AaeaioeiO?aioeiae/,

caa?aeoaa/ eaoaae?e iaoieia?/ii? o?c?ieia?? Aoeiaei

nueei? aea?aeaaii? iaaee/ii? aeaaeai??

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe

O?aoye Iaoae?y Ieeiea?aia,

Ee?anueeee ?inoeooo aaiaoieia?? ? ia?aeeaaiiy e?ia? IIC
Oe?a?ie,caa?aeoaa/ aaiaoieia?/ii? ee?i?ee aeey aei?ineeo

Eaiaeeaeao iaaee/ieo iaoe

Noaaeea Aaneeue Aiai?eiae/,

IAe? iaaeeoeeie i?aoe? AII Oe?a?ie, caa?aeoaa/ eaai-?aoi???
iaaeeei-a?ieia?/ieo aeine?aeaeaiue.

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.
Aiaiii-

eueoey IIC Oe?a?ie, eaoaae?a iaoieia?/ii? o?c?ieia??,

i. Ee?a

Caoeno a?aeaoaeaoueny “16” eenoiiaaea 1999 ?. i 14 aiaeei? ia
can?aeaii? niaoe?ae?-ciaaiii? a/aii? ?aaee Ae 26.198.01 i?e ?inoeooo?
o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie, 01024, Ee?a-24, aoe.
Aiaiiieueoey, 4.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo o?c?ieia??

?i. I.I.Aiaiiieueoey IAI Oe?a?ie (01024, Ee?a-24, aoe. Aiaiiieueoey, 4.)

Aaoi?aoa?ao ?ic?neaiee “ 15 ” aeiaoiy 1999 ?.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? a?ieia?/ieo iaoe Ni?ie?ia-Ia??ia C.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie.

Ca inoaii? ?iee c?inoa? aeieia?/ia iaaaioaaeaiiy ia i?aai?ci ethaeeie,
ui iaoiiaeaii caa?oaeiaiiyi ioi/oth/iai na?aaeiaeua enaiia?ioeeaie,
cie?aia aaaeeeie iaoaeaie. sseui aino?a io?o?iiy eaaei??i, oae??i,
naeioeai ? ?ooooth ? aeineoue aeia?a aea/aieie, oi ?o o?ii?/ia ae?y ia
i?aai?ci aeine?aeaeaia iaaeinoaoiuei (Aaoeui A.I. e niaao.,1991,
Aeaaeaiei E.E. e niaao., 1997).

A?aeiii, ui ca oiia aeieia?/iiai iaaeaaiiieo//y ?icaeaa?oueny oae caaiee
neiae?ii aia?aiieanoe/iiai aeao?oeeoo. A?i oa?aeoa?eco?oueny cieaeaiiyi
i?ioean?a o?c?ieia?/ii? ?aia?aoe?? oeaiei ? i?ecaiaeeoue aei
iioeiaeaeaiiy aaaaoueio i?aai?a ? nenoai i?aai?cio (Iaiiiiyueo E.I,
Iaiiiiyueo A.E., 1996). Aeiaaaeaii, ui ca inoaii? aeanyoe??//y
ca?eueoo?oueny e?euee?noue o?ii?/ieo caoai?thaaiue c eaoaioiei
ia?aa?aii, c’yaeythoueny iia?, aeieia?/ii iaoiiaeai? oai?iae, ye?
caeaoi? aeinyaaoe noaoono iicieia?/ieo iaeeieoeue (Eoiaeeaa TH.E.,
O?aooaiaa?a E.I.,1991, Aeaaeaiei E.E.e niaao.,1997).

A aaaaoueio aeiaaeeao ee?i?/ii anoaiiaeoe ia?aeiio i?e/eio iaoieia?/iiai
i?ioeano ia aaea?oueny, oiio i?e aeieia?/ii-caeaaeieo caoai?thaaiiyo
canoiniao?oueny ia iaoiaaiaoe/ia, a neiioiiaoe/ia, aai iineiae?iiia
oa?ai?y (Io?iocaiaaoia A., Iie?caeiaa E.,1996). C ?ioiai aieo a?aeiii,
ui ii?ooaiiy aia?aiieanoeee ee?oei caeaaeaoue a?ae noaio
aioo??oiueii?aaiii? i?e?ioee?eoeyoe??, yea, a naith /a?ao, iaoiiaeaia
?aieia?/ieie aeanoeainoyie e?ia? (Aiae?aaiei A.A.,1979, Aiae?aaiei A.A.e
niaao.,1981, A?oaiiiia A.N.e niaao.,1993). Inoaii? o?nii iia’ycai? c
nenoaiith ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ? oeaieiiei o?a?eiie?cii
(Aa?eaaai C.N.,1980). Iaeiae, c oi/ee ci?o ?icaeoeo aeieia?/ii-caeaaeii?
iaoieia??, ieoaiiy ci?i a nenoaiao eiaaoeyoe?eiiai,
o?iiaioeeoa?ii-noaeeiiiai aaiinoaco, i?ioecn?aeath/i? ? o?a?eiie?oe/ii?
nenoai, iaiaiaaeaiiai i?ioaie?co, a oaeiae oeaieiiiai o?a?eiie?co
aea/ai? iaaeinoaoiuei.

Iaoa aeine?aeaeaiiy iieyaaea o ?ic?iaoe? niinia?a iaoiaaiaoe/ii?
ei?aeoe?? ii?ooaiue o nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?ae
aieeaii iaeeo aeic oei?enoeo niieoe aaaeeeo iaoae?a (eaaei?th, naeioeth,
oae?th ? ?ooo?).

Aeey aeinyaiaiiy iaoe ?iaioe iio??aii aoei ae??oeoe ianooii? caaaeaiiy:

— aea/eoe aieea iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth
oa ?ooo? ia o?iiaioeeoa?ii-noaeeiiee ? eiaaoeyoe?eiee aaiinoac a
noao?ii?/iiio aenia?eiaio?;

— aeine?aeeoe ci?ie iaiaiaaeaiiai i?ioaie?co, i?ioecn?aeath/i? ?
o?a?eiie?oe/ii? nenoai i?ae o?ii?/iei aieeaii iaeeo aeic oei?enoeo
niieoe eaaei?th, oae?th, naeioeth ? ?ooo?;

— aeyaeoe ii?ooaiiy oeaieiiiai o?a?eiie?co a aeeoo?ai aaaeeeaeo i?aaiao
(aieiaiee iicie, na?oea, eaaai?, ia/?iea, ie?ee) i?e noao?ii?/iiio
aieea? ia i?aai?ci iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th,
naeioeth oa ?ooo?;

— a iiaeaeueieo aenia?eiaioao in vitro anoaiiaeoe caaaeuei? iaoai?cie
ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?ae aieeaii
iaeeo aeic aaaeeeo iaoae?a;

— iaoiaaiaoe/ii iaa?oiooaaoe ? ?ic?iaeoe niiniae ei?aeoe?? anoaiiaeaieo
ii?ooaiue ?aaoeyoe?? aa?aaaoiiai noaio e?ia?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa anoaiiaeaii, ui caaaeueiith caeiiii??i?noth o?ii?/iiai aieeao ia
i?aai?ci iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth ? ?ooo?
? ia?aeiia aeoeaaoe?y o?iaioeeoa?ii-noaeeiiiai aaiinoaco oa c’yniaaii,
ui ci?ie eiaaoeyoe?eiiai aaiinoaco i?e o?ii?/i?e ?ioieneeaoe?? aaaeeeie
iaoaeaie iathoue aoi?eiiee oa?aeoa?. Oea iaoiiaeaii ?icaeoeii
aioo??oiueinoaeeiii? aaiieiaaoeyoe?? ? aaeueioaaiiyi o?a?eiiaaiaco i?ae
aieeaii ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o, aai i?iaeoeo?a
aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio.

Aia?oa anoaiiaeaii, ui iae? aeice oei?enoeo niieoe eaaei?th, oae?th,
naeioeth ? ?ooo? caeiiii??ii cieaeothoue aeoeai?noue i?ioecn?aeath/i?
nenoaie e?ia? ? aeiaaaeaii, ui i?e o?ii?/i?e ?ioieneeaoe?? iaeeie
aeicaie oei?enoeo niieoe naeioeth ? oae?th iiaeeeai ia? i?noea
a?eo?ioeeoa?iee eiiiiiaio aeoeaaoe?? ia?aeiiiai aaiinoaco.

Aia?oa aeyaeaii caeiiii??i?noue aeoeaaoe?? iaiaiaaeaiiai i?ioaie?co i?ae
aieeaii iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth ? ?ooo?
oa iieacaii iniaeeaino? ci?i oeaieiiiai o?a?eiie?co a aeeoo?ai
aaaeeeaeo i?aaiao i?ae aieeaii iaeeo aeic oei?enoeo niieoe eaaei?th,
oae?th, naeioeth ? ?ooo?.

Aia?oa ?ic?iaeaiee iaoiaaiaoe/ii iaa?oioiaaiee niin?a ei?aeoe??
ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?e o?ii?/i?e
?ioieneeaoe?? aaaeeeie iaoaeaie ca aeiiiiiaith noaa?eueiiai aiaeiao
i?inoaoeeee?io — i?aia?aoo II-706.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

A ?acoeueoao? i?iaaaeaiiai aeine?aeaeaiiy anoaiiaeai? caaaeuei?
caeiiii??iino? oiene/iiai aieeao oei?enoeo niieoe aaaeeeo iaoae?a ia
nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia?, ui a?aee?eaa? iiaeeeaino?
ee?i?/ii? ai?iaaoe?? a aeieia?/ii caa?oaeiaieo ?aa?iiao Oe?a?ie iiaeo
iaoiae?a e?eoaaiiy oai?ia, ye? noi?iaiaeaeothoueny ii?ooaiiyie
?aieia?/ieo aeanoeainoae e?ia? aiane?aeie ?icaeoeo noaee?i?/ieo oi?i
aioo??oiueinoaeeiii? aaiieiaaoeyoe??.

Aenia?eiaioaeueia iaa?oiooaaiiy aoaeoeaiino? i?aia?aoo II-706 a?aee?eaa?
ia?niaeoeae aeey ee?i?/ii? ai?iaaoe?? iiaeo iaoiae?a i?io?eaeoeee oa
e?eoaaiiy o?ii?/ieo ?ioieneeaoe?e aaaeeeie iaoaeaie ?c canoinoaaiiyi
noaa?eueiiai aiaeiaa i?inoaoeeee?io.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo.

?acoeueoaoe ?iaioe ai?iaaaeaeai? a iaa/aeueiee i?ioean ia eaoaae?ao
iaoieia?/ii? o?c?ieia?? Euea?anueeiai, Aeiiaoeueeiai, Eoaainueeiai,
Oa?e?anueeiai aea?aeaaieo iaaee/ieo oi?aa?neoao?a, Oa?iii?euenueei?
iaaee/ii? aeaaeai??, IAe? iaaeeei-aeieia?/ieo i?iaeai (i. *a?i?aoe?) a
oaeiae ia eaoaae?ao oa?iaeieia?? ? iaaee/ii? o?i?? Aoeiaeinueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (i.*a?i?aoe?).

Iniaenoee aianie caeiaoaa/a.

Aeena?oaioii naiino?eii aeeiiai? an? aenia?eiaioaeuei? aeine?aeaeaiiy,
i?iaaaeaii aiae?c io?eiaieo aeaieo, iaienai? an? ?icae?ee
aeena?oaoe?eii? ?iaioe, noi?ioeueiaai? aeniiaee ? i?aeoe/i?
?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

I?i iniiai? io?eiai? aeai? aeiiia?aeaeiny ia iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeuei? ieoaiiy ee?i?/ii? iaaeeoeeie oa aeieia??”
(Iieoaaa, 1998) I?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo
a/aieo (Oa?iii?eue, 1998), i?aenoieiaeo iaoeiaeo eiioa?aioe?yo
ni?a?ia?oiee?a Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeai?? (*a?i?aoe?,
1996, 1997, 1998).

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o ye? a?aeia?aaeothoue ??
iniiai? iieiaeaiiy, c ieo 5 o oaoiaeo iaoeiaeo aeo?iaeao, 3 – a
iaoa??aeao ? oacao eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??.

?iaioa neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, iienaiiy iaoa??ae?a
oa iaoiae?a aeine?aeaeaiiy, 5 ?icae?e?a aeanieo aeine?aeaeaiue,
iaaiai?aiiy io?eiaieo aeaieo, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e oa
iieaae/eea e?oa?aoo?e. Aeena?oaoe?y aeeeaaeaia ia 178 noi??ieao
iaoeiiieniiai oaenoo, ?ethno?iaaia 34 oaaeeoeyie ? 35 ?enoieaie.
A?ae?ia?ao?y aeeth/a? 289 e?oa?aoo?ieo aeaea?aea, c ieo 109 — ?iicaiieo
aaoi??a.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Aeey ae??oaiiy iinoaaeaieo caaaeaiue aoee i?iaaaeai? na??? aenia?eiaio?a
in vitro oa in vivo. A ?iaio? aeei?enoaii 300 naioe?a oa naiie a?eeo
uo??a c ianith o?ea 0,1530,018 ea. Oei?eno? niieoee eaaei?th, oae?th,
naeioeth oa ?ooo? aaiaeeee aioo??oiueioeoieiai, uiaeaiii, iaoaeaaei
ciiaeii a aeicao aeey CdCl2, HgCl2 ii 0,05 ia/ea, aeey PbCl2, TlCl — ii
0,5 ia/ea iane o?ea. Aeine?aeaeaiiy i?iaiaeeee /a?ac 2 oeaei? i?ney
aaaaeaiiy oei?enoeo niieoe aaaeeeo iaoae?a.

E?ia caae?aee c /a?aaii? ai?oe nee?eiiiaaiei oi?eoeai, i?ae iaiaooaeiaei
ia?eicii (40 ia/ea iane o?ea), noaa?e?coaaee oeeo?aoii iao??th,
oeaio?eooaoaaee ? a?aeie?aiethaaee ieacio a?ae oi?iaiieo aeaiaio?a.
A?ae?aco i?ney aaoaiac?? uo??a iaaaaeee aioo??oi?o i?aai?a (ie?ee,
na?oea, ia/?ieo, aieiaiee iicie ? eaaai?) caii?iaeoaaee o ??aeeiio acio?
aeey iiaeaeueoeo a?io?i?/ieo aeine?aeaeaiue.

Noai o?iiaioeeoa?ii-noaeeiiiai aaiinoaco ioe?ithaaee ca a?aenioeii
aaeaaceaieo o?iiaioeeo?a (A.I. Ieuaiei e ae?., 1980), a oaeiae ca
?iaeaenii niiioaiii? aa?aaaoe?? o?iiaioeeo?a (A. Tacolla et al., 1980).
Caaaeueiee eiaaoeyoe?eiee iioaioe?ae e?ia?, iioaioe?eio aeoeai?noue
ieaci?iiaaio, aioeieaci?ie, ??aaiue o?a?eiiaaio a ieaci? e?ia?,
aeoeai?noue aioeo?iia?io III, o?a?einoaa?e?coth/iai oaeoi?o,
eiioeaio?aoe?th ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o oa i?iaeoeo?a
aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio, a oaeiae o?ie?iacio aeoeai?noue na/?
aecia/aee ca aeiiiiiaith iaai??a ?aaeoea?a o??ie “Simko Ltd.” (Euea?a).

E??i oiai, c aeei?enoaiiyi ?aaeoea?a oe??? o??ie aecia/aee
oa?iaioaoeaiee ? iaoa?iaioaoeaiee o?a?eiie?c a na/?, ieaci? e?ia? ?
oeaiei aioo??oi?o i?aai?a. I?eioeei iaoiaeo iieyaa? a oiio, ui i?e
?ieoaaoe?? acio?a?eio ?c noaiaea?oiith e?euee?noth ieaci?iiaaio a
i?enooiino? aeoeaaoi??a o?a?eiie?co, ye? i?noyoueny a na/?, ieaci? e?ia?
aai a oeaieiao, ooai?th?oueny ieaci?i, aeoeai?noue yeiai ioe?ith?oueny
ca nooiaiai caaa?aeaiiy ?ic/eio a eoaeiiio na?aaeiaeu?, aiane?aeie
e?ceno acio?a?eio, a i?enooiino? -ai?iieai?iiiai? eeneioe
(iaoa?iaioaoeaiee o?a?eiie?c), aai aac ia? (noia?ia o?a?eiie?oe/ia
aeoeai?noue). ??cieoey i?ae ieie a?aeaeca?eaeth? noai oa?iaioaoeaiiai
o?a?eiie?co. Ca aiaeia?/iei iaoiaeii aecia/aee i?ioaie?oe/io
aeoeai?noue, aeei?enoiaoth/e aciaeueaoi?i, acieaca?i oa acieie.

A na??? iiaeaeueieo aenia?eiaio?a aeei?enoiaoaaee 2 ii?oe?? oe?eueii?
oeeo?aoii? e?ia?: aei ia?oi? i?ia??ee aeiaeaaaee 0,1 ie ?cioii?/iiai
oei?enoiai iao??th, aei ae?oai? — 0,1 ie ?ic/eio oei?enoeo niieoe
eaaei?th, oae?th, naeioeth aai ?ooo? a e?ioeaa?e eiioeaio?aoe?? 10
ia/ie. I?ney 30 oaeeei ?ieoaaoe?? o aiaeyiiio oa?iinoao? i?e oaiia?aoo??
37iN caienoaaee o?iiaiaeanoia?aie.

Ei?aeoe?th ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? a
aenia?eiaio? i?iaiaeeee ca aeiiiiiaith i?aia?aoa “II-706” – noaa?eueiiai
aiaeiaa i?inoaoeeee?io, neioaciaaiiai a ?inoeooo? o?i?? Anoiinueei? AI.
I?aia?ao aaiaeeee uo?ai ca 30 oa ia?aae aaoaiac??th,
aioo??oiueii/a?aaaiii, o aeic? 0,56 ia/ea.

Noaoenoe/ia ia?iaea io?eiaieo aeaieo i?iaaaeaia ia PC Pentuim II ca
aeiiiiiaith “Microsoft Excel 7.0” ? i?ia?aie “Statgraphics” (NOA). A
oaaeeoeyo cia/aiiy “?” iaaaaeai? eeoa aeey a??ia?aeieo (?=0,05 aai
iaioa) ??cieoeue iieaciee?a, ui aea/aeeny.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy

Coao?ii?/ia aaeeaaiiy oaa?eiaie iaeeo aeic oei?enoiai eaaei?th
i?ecaiaeeei aei aeoeaaoe?? ia?aeiiiai aaiinoaco (?en. 1) i?e
iiaeiaaeaii? /aniaeo oa?aeoa?enoee cn?aeaiiy e?ia? (?en. 2).

?en. 1 Aieea oei?enoiai eaaei?th ia aaeaaceaii-aa?aaaoe?eio caeaoi?noue
o?iiaioeeo?a (a % a?ae eiio?ieth)

?NAO — ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a

IAO — i?ioeaio aaeaaceaieo o?iiaioeeo?a

?en. 2 Aieea oei?enoiai eaaei?th ia /ania? oa?aeoa?enoeee caaaeueiiai
iioaioe?aeo cn?aeaiiy e?ia? (a % a?ae eiio?ieth)

AIO* — aeoeaiaaiee ia?oe?aeueiee o?iiaiieanoeiiaee /an

I?ioecn?aeath/ee iioaioe?ae e?ia? ciaiooaaany, I?i oea na?ae/eei
cieaeaiiy aeoeaiino? aioeo?iia?io ??? c 115,600,95% a eiio?ie? aei
100,701,35% a aeine?ae? (p<0,001; n=24), ui noi?iaiaeaeoaaeiny ?icaeoeii aioo??oiueinoaeeiii? aaiieiaaoeyoe??: eiioeaio?aoe?y ?ic/eiieo eiiieaen?a o?a?ei/iiiiia?o a ieaci? e?ia? c?inoaea ia 112,51% (p<0,05; n=24). O?iaiaeanoia?ao?/i? aeai? aeacoaaee ia a?iieiaaoeyoe?ei? ci?ie (?en. 3), ?en. 3 Oa?aeoa?enoeea aieeao oei?enoiai eaaei?th ia iniiai? iieacieee o?iiaiaeanoia?aie *- ?icoeo?oaaiiy nei?i/aiue aeea. Oaae.1, n.8. ui aoei coiiaeaii iaeiie/aiiyi a ieaci? e?ia? ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o oa i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio, ye? aaeueiothoue o?iia?ii- oa o?a?eiiaaiac (AEeea A.A., Eooie?oe A.E., 1986). A aeaiiio aeiaaeeo iaaei??ia aeoeaaoe?y o?a?eiie?co i?ecaiaeeea aei e?ceno ia o?eueee aioo??oiuei- oa iicanoaeeiieo aeaiiceo?a o?a?eio, aea ? aeeeeeaea aeniaaeaiiy ?aca?a?a o?a?eiie?co, i?i ui na?ae/eei cieaeaiiy iioaioe?eii? aeoeaiino? ieaci?iiaaio (14,800,59 oa a eiio?ie?, oa 17,380,87 oa a aeine?ae?, ?<0,05; n=23) ? i?eai?/aiiy Oaaaiai-caeaaeiiai o?a?eiie?co (15,200,71 oa oa 17,460,67 oa, p<0,05; n=23, a?aeiia?aeii). Ca eaaei??ai? ?ioieneeaoe?? c?inoaea o?ie?iacia aeoeai?noue na/? (c 0,220,09 iae a eiio?ie? aei 1,360,13 iae a aeine?ae?; p<0,001; n=23). I?e ?ieoaaoe?? oe?eueii? e?ia? c oei?enoei eaaei??i (?en. 4) niinoa??aaeiny nei?i/aiiy /ano niaoeeo?/iiai o?iiaioeeoa?iiai cn?aeaiiy e?ia?, ciaioaiiy ?ioaineaiino? neia?aceno ? caaaeueiiai /ano cn?aeaiiy e?ia? c a?aeiia?aeiei i?aeaeuaiiyi ca??iiai ?iaeaeno eiaaoeyoe?? oa eooa . Oei?enoee naeiaoeue aeeeeeaa eaoaioio oi?io aioo??oiueinoaeeiii? aaiieiaaoeyoe?? ia ??ai? ie?ie, i?i ui na?ae/eei iii??ia ca?eueoaiiy eiioeaio?aoe?? ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o a ieaci? e?ia? i?e iiya? o na/? aaeeei? ?en. 4 Aieea oei?enoiai eaaei?th ia o?iiaiaeanoia?ao?/i? iieacieee cn?aeaiiy e?ia? ca oiia i?yii? ae?? iaoaeo ia oe?eueio e?ia in vitro (a % a?ae eiio?ieth) e?eueeino? i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio ca cieaeaiiyi aeoeaiino? o?a?einoaa?e?coth/iai oaeoi?a (o.O???- Eae?-Ei?aia) (?en. 5). ?en. 5 Aieea oei?enoiai naeioeth ia e?eoa??? aioo??oiueinoaeeiii? aaiieiaaoeyoe?? (a % a?ae eiio?ieth) ?EOI - ?ic/eii? eiiieaene o?a?ei-iiiiia?o IAeO - i?iaeoeoe aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio a na/? Ci?ie o?a?eiie?oe/ii? nenoaie e?ia? i?ae aieeaii oei?enoiai naeioeth oa?aeoa?ecoaaeeny ca?eueoaiiyi noia?iiai, iaoa?iaioaoeaiiai ? oa?iaioaoeaiiai o?a?eiie?co (?en. 6). Iaea?eueo nooo?a? ci?ie i?ae aieeaii o?ii?/ii? naeioeaai? ?ioieneeaoe?? niinoa??aaeeny c aieo oeaieiiiai o?a?eiie?co a e??eia?e ?a/iaei? ie?ie: noia?ia o?a?eiie?oe/ia aeoeai?noue cieaeoaaeany ca ?aooiie oa?iaioaoeaiiai o?a?eiie?co a 5,98 ?ace (?<0,01; n=24). ?en. 6 Aieea oei?enoiai naeioeth ia o?a?eiie?oe/io aeoeai?noue ieacie e?ia? (a % a?ae eiio?ieth) NOA - noia?ia o?a?eiie?oe/ia aeoeai?noue IOA - iaoa?iaioaoeaia o?a?eiie?oe/ia aeoeai?noue OOA - oa?iaioaoeaia o?a?eiie?oe/ia aeoeai?noue I?ioaie?oe/ia aeoeai?noue e?ia? i?ae aieeaii oei?enoiai naeioeth oa?aeoa?ecoaaeany ca?eueoaiiyi e?ceno acieieo ia 95,45% (p<0,02; n=24), acieaca?io - 166,12% (p<0,001; n=24) oa aciaeueaoi?io - 352,00% (p<0,001; n=24), ui na?ae/eoue i?i i?aeaeuaiiy aeaa?aaeaoe?? eieaaaio, aaeeei- oa iecueeiiieaeoey?ieo a?ee?a. Oeae iaoae aeyaea iaea?eueoo aaiie?oe/io caeaoi?noue: cia/ii i?aeaeueany aaiieiaaoeyoe?eiee iioaioe?ae e?ia?. Iiaeia aeoiaoe, ui oea a?aeaoeiny caaaeyee a?eo?ioeeoa?iei oaeoi?ai aaiieiaaoeyoe??, oae ye ia oii? a?ia?eiaaoeyoe?eieo ci?i niinoa??aaeiny ciaioaiiy eiao?oe??ioo aeanoe/iino? (A) oa iiaeoey i?oaeiino? (Q) e?ia’yiiai caonoea, ye? oa?aeoa?ecothoue caeaoi?noue caonoea aei ?ao?aeoe??. A a?eo?ioeeoao, ye a?aeiii c e?oa?aoo?e, ?ao?aeoicei a?aenooi?e. (?en.7). ?en. 7 Aieea oei?enoiai naeioeth ia o?iiaiaeanoia?ao?/i? iieacieee cn?aeaiiy e?ia? ca oiia i?yii? ae?? iaoaeo ia oe?eueio e?ia in vitro (a % a?ae eiio?ieth) Ca?aeii aeaieo o?iiaiaeanoia?ao??, i?ae aieeaii oei?enoiai oae?th o uo??a cieaeo?oueny caaaeueiee iioaioe?ae aaiieiaaoeyoe??, ui iaoiaaiaoe/ii iia’ycaii c ii?ooaiiyie o?iia?ii- ? o?a?eiiaaiaco (oaae. 1). O?iiaiaeanoia?ao?/i? aeai? a?aeiia?aeaee ?acoeueoaoai eiaaoeiiao?e/ieo oano?a: i?ae aieeaii oei?enoiai oae?th ca?eueooaaeeny iieacieee /ano ?aeaeueoeeo?eaoe?? ieacie e?ia? a 1,8 ?ace, i?io?iia?iiaiai a 2,2 ?ace, o?iia?iiaiai a 3,3 ?ace ? aeoeaiaaiiai ia?oe?aeueiiai o?iiaiieanoeiiaiai /ano ia 47,08%. Nooo?ai cieaeoaaany i?ioecn?aeath/ee iioaioe?ae e?ia?, i?i ui na?ae/eei ciaioaiiy aeoeaiino? aioeo?iia?io ??? c 115,600,95% aei 77,071,50% (?<0,001; n=24). A?aenooi?noue i?e oeueiio ci?i eiioeaio?aoe?? o?a?eiiaaio a ieaci? e?ia? (3,440,24 a/e a eiio?ie? oa 3,460,09 a/e a aeine?ae?) na?ae/eoue i?i oa, ui a?iieiaaoeyoe?ei? ci?ie, ye? aoee iaea?eueo ae?aaeai? ia aoai? o?a?eiiaaiaco, iathoue ia e?euee?nio, a ye?nio iniiao. Oaaeeoey 1 Aieea oei?enoiai oae?th ia iieacieee o?iiaiaeanoia?aie o a?eeo uo??a (picscalex100010009000003e0000000030017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c022002a0041200000026060f001a00ffffffff0000100 00000c0ffffffbaffffff60040000da0100000b00000026060f000c004d6174685479706 50000300009000000fa02000012000000000000002200040000002d01000005000000140 24f0040000500000013024f000a010500000014024f0090030500000013024f005a04170 00000fb0240fe000000000000bc02000000cc0402001054696d6573204e657720526f6d6 16e2043797200cc7e040000002d01010008000000320ac00189030100000078000800000 0320ac001840201000000530008000000320ac001390001000000780010000000fb0240f e0000000000009001000000020002001053796d626f6c0002040000002d0102000400000 0f001010008000000320ac001570101000000b1000a00000026060f000a00ffffffff010 00000000010000000fb021000070000000000bc02000000cc0102022253797374656d00c c040000002d01010004000000f0010200030000000000) Iieacieee, ui aea/aeenyEiio?ieue, n=10Aaaaeaiiy oei?enoiai oae?th, n=14Oaeaee?noue a?aeiiaeaiiy o?iia?io r, nae95,403,52200,5718,47; p<0,001O?iiaiaeanoia?ao?/ia eiinoaioa o?iia?io K, nae178,2014,44319,7119,48; p<0,001Iaeneiaeueia aiie?ooaea Am, ii35,501,8630,211,24; p<0,05Aeanoe/i?noue e?ia’yiiai caonoeo E, iae.56,184,4143,892,61; p<0,05Iiaeoeue i?oaeiino? caonoeo e?ia? Q, I/i2337,8026,51263,9815,72; p<0,05Eiinoaioa niaoeeo?/iiai cn?aeaiiy e?ia? t, nae542,3040,01559,2941,31Eiinoaioa neia?aceno S, nae720,2034,01879,0034,42; p<0,01Caaaeueiee /an cn?aeaiiy e?ia? O, nae815,6033,921079,2928,07; p<0,001Ca??iee ?iaeaen eiaaoeyoe?? Ci, iae.0,810,080,360,03; p<0,001Eooiaa eiinoaioa , a?aaeone13,290,858,860,31; p<0,001? - nooi?iue aeinoia??iino? ??cieoeue iieaciee?a a ii??aiyii? c eiio?ieai n - /enei niinoa?aaeaiue Oea i?eiouaiiy i?aeoaa?aeaeo?oueny ca?eueoaiiyi ai?noo a ieaci? e?ia? ?ic/eiieo eiiiaen?a o?a?ei-iiiiia?o (0,400,13 iea/e a eiio?ie? oa 6,861,14 iea/e a aeine?ae?; p<0,001; n=24) oa i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio (a?aenooi? a eiio?ie?, 1,000,28 iea/e a aeine?ae?; n=24) ca aeayeei i?eai?/aiiyi aeoeaiino? oaeoi?a Eae?-Ei?aia (108,094,11% oa 100,071,84%, a?aeiia?aeii). A?iieiaaoeyoe?ei? cnoae a nenoai? aoi?eiiiai aaiinoaco noi?iaiaeaeoaaeeny aeoeaaoe??th o?iiaioeeoa?ii-noaeeiiiai aaiinoaco, ui aeaco? ia aiaeioae?aeueii-o?iiaioeeoa?i? iioeiaeaeaiiy (?en. 8). Niinoa??aaeiny ca?eueoaiiy noia?ii? o?a?eiie?oe/ii? aeoeaiino? e?ia? a 10,6 ?ace, iaoa?iaioaoeaii? - a 31,5 ?ace, oa?iaioaoeaiiai o?a?eiie?co - a 8,2 ?ace (p<0,001; n=24), ui i?ecaiaeeei aei aeniaaeaiiy ?aca?a?a ieaciiai? nenoaie o?a?eiie?co: iioaioe?eia aeoeai?noue ieaci?iiaaio cieaeoaaeany c 14,800,59 oa aei 22,600,91 oa, a Oaaaiai-caeaaeiee o?a?eiie?c ciaiooaaany c 15,200,71 oa aei 23,210,66 oa (p<0,001; n=24). Aioeo?a?eiie?oe/ia aeoeai?noue e?ia? c?inoaea ia 23,56%). Oei?enoee oae?e i?aeaeuoaaa o?a?eiie?oe/io aeoeaiinoue e??eiai? ?a/iaeie ie?ie ca ?aooiie ca?eueoaiiy iaoa?iaioaoeaiiai o?a?eiie?co c 1,640,27 E440/ie/oa aei 10,050,67 E440/ie/oa (p<0,001; n=16). A i?iea?ae? c?inoaea oa?iaioaoeaia o?a?eiie?oe/ia aeoeai?noue (4,061,08 E440 / ie / oa a eiio?ie? oa 25,081,50 E440/ie/oa a aeine?ae?; ?en. 8 Oa?aeoa?enoeea aaeaaceaii-aa?aaaoe?eii? caeaoiino? o?iiaioeeo?a i?e o?ii?/i?e cao?aaoe? uo??a iaeeie aeicaie oei?enoiai oae?th (a % a?ae eiio?ieth) ?NAO - ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a IAO - i?ioeaio aaeaaceaieo o?iiaioeeo?a p<0,001; n=16. Aenie? iieacieee o?a?eiie?co niinoa??aaeeny o ia/?ioe? caaaeyee i?aeaeuaiith ?ioaineaiino? aiceiaoe/iiai e?ceno o?a?eio a 3,7 ?ace (p<0,001; n=16). A oie aea /an e?cen acieieo ciaiooaaany a 2,6 ?ace, acieaca?io - a 1,8 ?ace, aciaeueaoi?io - a 3,2 ?ace (p<0,01; p<0,01; p<0,001, a?aeiia?aeii, i?e n=16). Aieiaiith eaieith aieeao oei?enoi? ?ooo? ia nenoaio cn?aeaiiy e?ia? ca aeaieie o?iiaiaeanoia?aie aoa o?iiaioeeoa?ii-noaeeiiee aaiinoac (eiinoaioa niaoeeo?/iiai o?iiaioeeoa?iiai cn?aeaiiy e?ia? nei?i/oaaeany c 542,3040,01 nae aei 324,7721,18 nae (p<0,001; n=24). ?acii c oei, niinoa??aaeiny ca?eueoaiiy /ano ?aeaeueoeeo?eaoe?? (80,292,35nae a eiio?ie? oa 124,144,79nae a aeine?ae?; p<0,001; n=24), iiaeiaaeaiiy i?io?iia?iiaiai ( 19,571,27nae oa 27,571,41nae, a?aeiia?aeii; p<0,01; n=24) oa o?iia?iiaiai /ano (17,710,92nae; 25,291,08nae, a?aeiia?aeii; p<0,001; n=24). Eiioeaio?aoe?y o?a?eiiaaio c?inoaea a 1,38 ?ac?a (p<0,001; n=24) i?e cia/iiio cieaeaii? aeoeaiino? aioeo?iia?io ??? (95,003,59% oa 38,291,38%, a?aeiia?aeii; p<0,001; n=24). I?i nooo?aee aieea oei?enoi? ?ooo? ia o?iiaioeeoa?ii-noaeeiiee aaiinoac na?ae/eei i?aeaeuaiiy i?ioeaioa aaeaaceaieo o?iiaioeeo?a oa ?iaeaeno ?o niiioaiii? aa?aaaoe?? (p<0,01; n=24). I?ioaie?oe/ia aeoeai?noue ieacie e?ia? ca acieieii c?inoaea a 3,0 ?ace (p<0,001; n=24), ca acieaca?iii - a 2,6 ?ac?a (p<0,001; n=24), ca aciaeueaoi?iii - a 2,3 ?ac?a (p<0,001; n=24), ui aeaco? ia nooo?ao aeoeaaoe?th iaiaiaaeaiiai i?ioaie?co. Aaciina?aaei?e eiioaeo oei?enoi? ?ooo? c oe?eueiith e?ia’th (?en.9) aeeeeeaa nei?i/aiiy oaeaeeino? ooai?aiiy o?iia?io ia 40,00% (p<0,001; n=10), ciaiooaaa niaoeeo?/io eiinoaioo o?iiaioeeoa?iiai cn?aeaiiy e?ia? ia 70,00% (p<0,001; n=10) ? i?aeaeuoaaa ia 20,00% iiaeoeue i?oaeiino? e?ia’yiiai caonoea (p<0,001; n=10). ?en. 9 Aieea aeeoei?enoi? ?oo? ia o?iiaiaeanoia?ao?/i? iieacieee cn?aeaiiy e?ia? ca oiia i?yii? ae?? iaoaeo ia oe?e?nio e?ia (a % a?ae eiio?ieth) Eiioeaio?aoe?y a?eueiiai aaiiaeia?io a ieaci? e?ia? c?inoaea ia 32% (p<0,001; n=10), ui aeaco? ia aaiie?oe/io aeanoea?noue oeueiai iaoaeo. O?ie?iacia aeoeai?noue na/? cieaeoaaeany ia 28,56%, (p<0,001; n=24). A oeaieiao ia/?iee noia?ia o?a?eiie?oe/ia aeoeai?noue c?inea ca ?aooiie ca?eueoaiiy iaoa?iaioaoeaiiai o?a?eiie?co ia 279,82% (p<0,001; n=24). Eiioeaio?aoe?y a ieaci? e?ia? ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o ca?eueooaaeany a 1,9 ?ace (p<0,001; n=24). A 6,2 ?ac?a c?inoaa ??aaiue i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio (p<0,001; n=24) ca cieaeaiiyi aeoeaiino? oaeoi?a Eae?-Ei?aia ia 23,86% (p<0,001; n=24). Caaaeueiith caeiiii??i?noth i?e o?ii?/i?e ae?? ia i?aai?ci a?eeo uo??a iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth ? ?ooo? aoei ia?aeiia i?aeaeuaiiy aeoeaiino? o?iiaioeeoa?ii-noaeeiiiai aaiinoaco, oiio aeey ei?aeoe?? ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?e o?ii?/i?e ?ioieneeaoe?? oaa?ei aaaeeeie iaoaeaie ia?aii i?aia?ao “II-706”. II-706 o uo??a c eaaei??aith ?ioieneeaoe??th (oaae.2) i?aeaeuoaaa oaeaee?noue ooai?aiiy o?iia?io oa ciaiooaaa o?iiaiaeanoia?ao?/io eiinoaioo o?iia?io a 1,45 ?ace oa ia 33,92%, a?aeiia?aeii. Eiinoaioa neia?aceno cieaeoaaeany ? aeinyaaea eiio?ieueiiai ??aiy, oaeiae ye ? caaaeueiee /an cn?aeaiiy e?ia? oa eooiaa eiinoaioa . Ca??iee ?iaeaen eiaaoeyoe?? aoa aeuei i?ae o a?oi? uo??a, ye? ia io?eioaaee II-706, ? i?aeoe/ii ia a?ae??ciyany a?ae eiio?ieueieo aeaieo. Ioaea, II-706 o uo??a c noao?ii?/iith ?ioieneeaoe??th oei?enoei eaaei??i ni?ey? ii?iae?caoe?? aaiieiaaoeyoe?eiiai iioaioe?aeo e?ia?. Oaaeeoey 2 Aieea i?aia?aoo II-706 ia iieacieee o?iiaiaeanoia?aie i?e coao?ii?/i?e ?ioieneeaoe?? oei?enoei eaaei??i (picscalex100010009000003e0000000030017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c022002a0041200000026060f001a00ffffffff0000100 00000c0ffffffbaffffff60040000da0100000b00000026060f000c004d6174685479706 50000300009000000fa02000012000000000000002200040000002d01000005000000140 24f0040000500000013024f000a010500000014024f0090030500000013024f005a04170 00000fb0240fe000000000000bc02000000cc0402001054696d6573204e657720526f6d6 16e2043797200cc7e040000002d01010008000000320ac00189030100000078000800000 0320ac001840201000000530008000000320ac001390001000000780010000000fb0240f e0000000000009001000000020002001053796d626f6c0002040000002d0102000400000 0f001010008000000320ac001570101000000b1000a00000026060f000a00ffffffff010 00000000010000000fb021000070000000000bc02000000cc0102022253797374656d00c c040000002d01010004000000f0010200030000000000) Iieacieee, ui aea/aeenyEiio?ieue, n=10Aaaaeaiiy oei?enoiai eaaei?th, n=14, 1 a?oiaAaaaeaiiy oei?enoiai eaaei?th +II706, n=10,2 a?oiaOaeaee?noue ooai?aiiy o?iia?io (r), Nae95,403,52161,0818,69 p<0,01111,367,48 p1<0,05O?iiaiaeanoia?ao?/ia eiinoaioa o?iia?io (E), Nae178,2014,44294,9237,32 p<0,01194,8817,65 p1<0,05Iaeneiaeueia aiie?ooaea Am, ii35,501,8530,772,1733,531,88Aeanoe/i?noue e?ia’yiiai caonoea (A), iae.56,184,4146,244,8250,443,77Iiaeoeue i?oaeiino? caonoea e?ia? (Q), I/i2337,8026,51278,0728,99303,3421,06Eiinoaioa niaoeeo?/iiai cai?oaiiy e?ia? (t), Nae542,3040,01619,3962,11510,2832,16Eiinoaioa neia?aceno (S), Nae720,2034,01913,8544,95 p<0,01705,1631,85 p1<0,001Caaaeueiee /an cai?oaiiy e?ia? (T), nae815,6033,921074,9249,97 p<0,001816,5237,11 p1<0,001Ca??iee ?iaeaen eiaaoeyoe?? (C)i, Iae0,810,080,470,070,660,06 p1<0,05Eooiaa eiinoaioa , A?aaeone13,290,858,850,78 p<0,00112,960,74 p1<0,001? - nooi?iue a??ia?aeiino? ??cieoeue iieaciee?a, ui aea/aeeny, a ii??aiyii? c eiio?ieai; p1- nooi?iue a??ia?aeiino? ??cieoeue iieaciee?a, ui aea/aeeny, a 1 oa 2 a?oiao; n - /enei niinoa?aaeaiue. II-706 ii?iae?coaaa aeoeai?noue aioeo?iia?io ??? (115,600,95% a eiio?ie? oa 118,491,26% a aeine?ae?) ? ciaiooaaa aeoeaiaaiee ia?oe?aeueiee o?iiaiieanoeiiaee /an ia 15,36% a?aeiinii a?oie uo??a, ye? ia io?eioaaee oeueiai i?aia?aoo (?< 0,001; n=24). ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a ciaiooaaany a 3,85 ?ac?a (?<0,001; n=24), a a?aenioie aaeaaceaieo o?iiaioeeo?a cieaeoaaany iaa?oue a?aeiinii eiio?ieueieo aeaieo (27,591,33% a eiio?ie?; 21,591,06% a aeine?ae?). Niinoa??aaeiny o?e?aciaa ciaioaiiy eiioeaio?aoe?? a ieaci? e?ia? ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o (0,850,15 iea/ie a a?oi? iae?eiaaieo oaa?ei; 0,280,09 iea/ie i?e canoinoaaii? II-706), i?aeaeuaiiy aeoeaiino? o?a?eiace ia 26,18% (?<0,001; n=24), a oaeiae ciaioaiiy noia?ii? o?a?eiie?oe/ii? aeoeaiino? e?ia? c 3,190,96 A440/ie/aiae aei 0,960,12 A440/ie/aiae (p<0,001; n=24), ye ca ?aooiie i?eai?/aiiy iaoa?iaioaoeaiiai (12,38 ?ac?a (p<0,001; n=24), oae ? oa?iaioaoeaiiai (a 2,5 ?ace; p<0,001; n=24) o?a?eiie?co. Cieaeaiiy iaoa?iaioaoeaiiai o?a?eiie?co o ei?oeeaeuei?e oeaiei? ie?ie a 2 ?ace (p<0,001; n=24) na?ae/eoue i?i oeeoii?ioaeoi?i? aoaeoe oeueiai i?aia?aoo. I?e aaaaeaii? II-706 ia oii? ?ioieneeaoe?? oei?enoei naeioeai o?iiaiaeanoia?ao?/ia eiinoaioa o?iia?io a??ia?aeii ia ci?ithaaeany, oaeiae, ye ? iieacieee iaeneiaeueii? aiie?ooaee cn?aeaiiy e?ia?, aeanoe/iino? oa iiaeoey i?oaeiino? e?ia’yiiai caonoea. Caaaeueiee /an cn?aeaiiy e?ia? ca?eueooaaany ia 45,24% ? aeinyaaa eiio?ieueieo aeaieo, ui aoei iaoiiaeaii ii?iae?caoe??th niaoeeo?/iiai o?iiaioeeoa?iiai cn?aeaiiy e?ia? oa eiinoaioe neia?aceno, ca ?aooiie ?o ca?eueoaiiy a?aeiinii aeaieo iae?eiaaieo oaa?ei ia 103,92% ? 65,33%, a?aeiia?aeii. I?e oeueiio, i?aia?ao II-706 ia ci?ithaaa oae? iieacieee, ye ca??iee ?iaeaen eiaaoeyoe?? oa eooiaa eiinoaioa ( ca??iee ?iaeaen eiaaoeyoe?? 0,840,05 i?e naeioeaaiio io?o?ii? oa 0,860,12 ia oii? aaaaeaiiy i?aia?aoo II-706; eooiaa eiinoaioa 15,290,74 ? 14,550,99 a?aeiia?aeii). II-706 ciaiooaaa /an ?aeaeueoeeo?eaoe?? ieacie e?ia? iaeaea aei ii?ie (53,86 1,81 a eiio?ie?; 58,55 2,42 i?e canoinoaaii? i?aia?aoo). Niinoa??aaeiny ciaioaiiy o?iia?iiaiai /ano a 1,60 ?ace (?<0,001;n=24). Aeoeaiaaiee ia?oe?aeueiee o?iiaiieanoeiiaee /an cieaeoaaany a?aeiinii iieaciee?a a?oie iae?eiaaieo oaa?ei a 1,25 ?ace (p<0,001; n=24). I?ney aaaaeaiiy II-706, i?ioecai?oath/ee iioaioe?ae e?ia? o uo??a c noao?ii?/iith ?ioieneeaoe??th naeioeai oa?aeoa?ecoaaany ca?eueoaiiyi aeoeaiino? aioeo?iia?io ??? ia 39,20% (p<0,001; n=24). Nooo?ai ciaiooaaany ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a a 4,46 ?ace (p<0,001; n=24) oa a?aenioie aaeaaceaieo o?iiaioeeo?a a 2,17 ?ace (p<0,001; n=24). ??aaiue ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o a ieaci? e?ia? cieaeoaaany(c 0,570,09 aei 0,350,09), a na/? cieeaee i?iaeoeoe aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio, aeoeai?noue oaeoi?a Eae?-Ei?aia c?inoaea ia 39,91% (p<0,001; n=24). I?ae aieeaii II-706 cieaeoaaany nooi?iue ii?ooaiiy o o?a?eiie?oe/i?e nenoai? e?ia?, ye? aeieeaee i?e noao?ii?/iiio aaaaeaii? naeioeth: noia?ia o?a?eiie?oe/ia aeoeai?noue ciaiooaaeany a 2,25 ?ace (?<0,05; n=24), iaoa?iaioaoeaiee o?a?eiie?c - ia 89,21%.(?<0,002; n=24). A?aeaoaaeiny aeinoia??ia ca?eueoaiiy o?a?eiie?oe/ii? aeoeaiino? ei?oeeaeueii? oeaieie ie?ie: noia?ia o?a?eiie?oe/ia aeoeai?noue ia?aaeuoaaea oaeo o a?oi? iae?eiaaieo oaa?ei ia 127,53% (?<0,001; n=24), a oa?iaioaoeaia - c?inoaea ia 327,32% (?<0,001; n=24). Niinoa??aaeiny ciaioaiiy ?ioaineaiino? iaoa?iaioaoeaiiai o?a?eiie?co c 4,050,17 aei 2,180,58 (?<0,01; n=24). I?e noao?ii?/iiio io?o?ii? uo??a oei?enoei oae??i, II-706 ia 38,92% (?<0,001; n=24) ca?eueooaaa oaeaee?noue ooai?aiiy o?iia?io oa cieaeoaaa o?iiaiaeanoia?ao?/io eiinoaioo o?iia?io ia 33,47% (?<0,001; n=24). Iieacieee iaeneiaeueii? aiie?ooaee, aeanoe/iino? e?ia’yiiai caonoea oa iiaeoey i?oaeiino? iaee oaiaeaioe?th aei c?inoaiiy. Iaeaea ia ci?ithaaeany eiinoaioa niaoeeo?/iiai cn?aeaiiy e?ia?, a eiinoaioa neia?aceno oa iieaciee caaaeueiiai /ano cn?aeaiiy e?ia? ciaiooaaeeny ia 15,00% (?<0,02; n=24) oa 19,00% (?<0,001; n=24) o ii??aiyii? c iae?eiaaiith a?oiith oaa?ei. Ia oii? oeeo ci?i niinoa??aaeiny a??ia?aeia ca?eueoaiiy ?ioaa?aoeaieo o?iaiaeanoia?ao?/ieo iieaciee?a aaiieiaaoeyoe?eiiai iioaioe?aeo - ca??iee ?iaeaen eiaaoeyoe?? ia?aaeuoaaa oaeee o a?oi? oaa?ei, ui ia io?eioaaee II-706, ia 55,60% (?<0,02; n=24), a eoo iaaeinoia??ii c?inoaa ia 6,70% (8,860,31 i?e io?o?ii? oae??i oa 9.450,72 ia oii? canoinoaaiiy II-706). I?ney aaaaeaiiy II-706 ii?iae?coaaeeny iieacieee: /ano ?aeaeueoeeo?eaoe?? c 78,79 3,09 o a?oi? iae?eiaaieo oaa?ei aei 60,42 1,75 i?e canoinoaaii? II-706, i?io?iia?iiaiai c 29,051,49; aei 16,931,13, a?aeiia?aeii, o?iia?iiaiai c 16,490,89 aei 8,530,66 oa aeoeaiaaiiai ia?oe?aeueiiai o?iiaiieanoeiiaiai /ano c 38,501,24 aei 28,180,41 (p<0,001; n=24). Niinoa??aaeiny cieaeaiiy eiioeaio?aoe?? ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o a ieaci? e?ia? c 6,861,14 aei 0,370,06 (p<0,001; n=24) oa ai?noo i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio o na/? (1,000,28 o a?oi? iae?eiaaieo oaa?ei; i?e canoinoaaii? II-706 eiioeaio?aoe?y aeacaieo niieoe ia aecia/aeany). Aeoeai?noue O??? oaeoi?o cn?aeaiiy e?ia? a??ia?aeii ca?eueooaaeanue ia 17,3% (?<0,001; n=24), ui a oe?eiio aeaco? ia nooo?aa cieaeaiiy ?ioaineaiino? aioo??oiueinoaeeiiiai cn?aeaiiy e?ia?. II-706 ca?eueooaaa aeoeai?noue aioeo?iia?io ??? ia 67,67% (p<0,001; n=24). ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a oa a?aenioie aaeaaceaieo o?iiaioeeo?a ciaiooaaeeny a 5,0 ?ac?a (?<0,001; n=24) ? 2,0 ?ace (?<0,001; n=24), a?aeiia?aeii. II-706 aeeeeeaa ciaioaiiy noia?ii? o?a?eiie?oe/ii? aeoeaiino? a 4,8 ?ac?a (?<0,001; n=24) ia?aaaaeii ca ?aooiie iaoa?iaioaoeaiiai o?a?eiie?co, ??aaiue yeiai ciaiooaaany a 14,0 ?ac?a (?<0,001; n=24), oiae? ye oa?iaioaoeaia o?a?eiie?oe/ia aeoeai?noue cieaeoaaeany eeoa ia 73,17% (?<0,001; n=24). C?inoaa o?a?eiie?oe/iee ?aca?a e?ia?, i?i ui na?ae/eei ca?eueoaiiy iioaioe?eii? aeoeaiino? ieaci?iiaaio ia 28,23% (?<0,001; n=24) oa Oaaaiai-caeaaeiiai o?a?eiie?co ia 26,37% (p<0,001; n=24). II-706 ciaiooaaa oeaieiio o?a?eiie?oe/io aeoeai?noue aioo??oi?o i?aai?a. A ei?oeeaeuei?e oeaiei? ie?ie oea ciaioaiiy a?aeaoaaeiny ca ?aooiie iaoa?iaioaoeaiiai o?a?eiie?co (c 10,050,67 aei 4,380,93, p<0,001; n=24). A i?iea?ae? o?a?eiie?oe/ia aeoeai?noue ciaiooaaeany, ye ca ?aooiie oa?iaioaoeaiiai a 2,58 ?ace (p<0,001; n=24), oae ? iaoa?iaioaoeaiiai o?a?eiie?co a 1,61 ?ace. II-706 o oaa?ei c ?oooiith ?ioieneeaoe??th ca?eueooaaa oaeaee?noue ooai?aiiy o?iia?io o 1,69 ?ac?a (?<0,001; n=28). Caaaeueiee /an cn?aeaiiy e?ia? ca?eueooaaany ia 18,91% (?<0,001; n=28 ) ? iaaeeaeaany aei eiio?ieueieo aeaieo. Ii?iae?coaaeeny iieacieee niaoeeo?/iiai o?iiaioeeoa?iiai cn?aeaiiy e?ia? (555,3336,28 i?e canoinoaaii? i?aia?aoo II-706, 542,3040,01 aeai? eiio?ieth) ? eiinoaioe neia?aceno (738,9827,44; 720,2034,01, a?aeiia?aeii). Ia 23,30% ca?eueooaaeany eooiaa eiinoaioa (?<0,05; n=28), ui na?ae/eoue i?i iie?auaiiy o?a?eiiaaiaco. Caaaeueiee iioaioe?ae cn?aeaiiy e?ia? o uo??a c noao?ii?/iith ?oooiith ?ioieneeaoe??th i?ae aieeaii II-706 oaeiae ci?ithaaany. Ia?o ca ana, ne?ae a?aei?oeoe ciaioaiiy /ano ?aeaeueoeeo?eaoe?? ieacie e?ia? ia 46,72% (?<0,001; n=24), nei?i/aiiy i?io?iia?iiaiai, o?iia?iiaiai, aeoeaiaaiiai ia?oe?aeueiiai o?iiaiieanoeiiaiai /ano ia 36,51%, 45,32% oa 27,4%, a?aeiia?aeii(?<0,001; n=24). ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a ciaiooaaany a 1,74 ?ac?a, a a?aenioie aaeaaceaieo o?iiaioeeo?a - a 1.34 ?ac?a (?<0,001; n=24). Ci?ie i?ioecn?aeath/iai iioaioe?aeo e?ia? oa?aeoa?ecoaaeeny nooo?aei ca?eueoaiiyi aeoeaiino? aioeo?iia?io ??? ia 205,05% (p<0,001; n=24). Ciaiooaaany ai?no ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o a ieaci? e?ia? a 3,62 ?ace (p<0,001; n=24) oa cieaeoaaeany eiioeaio?aoe?y i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio a na/? a 4,52% (p<0,001; n=24) ia oe? ca?eueoaiiy aeoeaiino? o?a?einoaa?e?coth/iai oaeoi?a ia 31,10% (?<0,001; n=24). II-706 ca?eueooaaa noia?io o?a?eiie?oe/io aeoeai?noue ieacie e?ia? a 2,44 ?ace (p<0,02; n=24) ca ?aooiie oa?iaioaoeaiiai o?a?eiie?co - a 5,43 ?ace (p<0,001; n=24) i?e cieaeaii? iaoa?iaioaoeaii? o?a?eiie?oe/ii? aeoeaiino? (c 0,110,02 aei 0,060,01; p<0,05; n=24). Niinoa??aaeiny ciaioaiiy e?eueeino? aioeieaci?i?a a ieaci? e?ia? ia 25,30% (?<0,001; n=24), a o?ie?iacia aeoeai?noue na/? ca?eueooaaeany ii??aiyiii c oaeith o a?oi? iae?eiaaieo oaa?ei ia 100,00% (?<0,05; n=24). I?ae aieeaii II-706 a?aeaoaaeiny ca?eueoaiiy oa?iaioaoeaii? o?a?eiie?oe/ii? aeoeaiino? a e??eia?e ?a/iaei? ie?ie ia 50,62% (p<0,02; n=24) i?e ciaioaii? iaoa?iaioaoeaiiai o?a?eiie?co ia 47,54% (p<0,01; n=24). Oaeei /eiii, caaaeueiith ?enith iaoai?cio ei?aaoth/iai aieeao noaa?eueiiai aiaeiaa i?inoaoeeee?io II-706 ia ii?ooaiiy a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?e noao?ii?/i?e ?ioieneeaoe?? oaa?ei iaeeie aeicaie oei?enoeo niieoe aaaeeeo iaoae?a ? noaa?e?caoe?y iaia?ai o?iiaioeeo?a ? cieaeaiiy aeoeaiino? o?iiaioeeoa?iiai eiiiiiaioa ia?aeiiiai aaiinoaco. Aeniiaee: 1. C aeei?enoaiiyi no/anieo eiaaoeiiao?e/ieo oa eiaaoeia?ao?/ieo iaoiaeee aeine?aeaeaii aieea oei?enoeo niieoe aaaeeeo iaoae?a (Cd, Tl, Pb,Hg) ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? o a?eeo uo??a, ui aeicaiey? anaa?/ii ioe?ieoe ci?ie eiaaoeyoe?eiiai, o?iiaioeeoa?ii-noaeeiiiai aaiinoaco, i?ioecn?aeath/i? ? o?a?eiie?oe/ii? nenoai, iaiaiaaeaiiai i?ioaie?co ? oeaieiiiai o?a?eiie?co, ye? aein? aoee iaaeinoaoiuei aea/aieie. 2. Aieiaieie aoaeoaie aeeoei?enoi? ?ooo? ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ? ciaioaiiy oaeaeeino? ooai?aiiy o?iia?io a oe?euei?e e?ia?; aeoeaaoe?y o?iiaioeeoa?ii-noaeeiiiai aaiinoaco; iiaeiaaeaiiy /aniaeo oa?aeoa?enoee cn?aeaiiy ieacie e?ia?; iiaeiaaeaiiy e?ceno aoaeiaoe?iiaeo caonoe?a; i?eai?/aiiy aeoeaiino? aioeo?iia?io ??? c ?icaeoeii aioo??oiueinoaeeiii? aaiieiaaoeyoe??. 3. I?ae aieeaii oei?enoiai eaaei?th o oaa?ei ?icaeaa?oueny aioo??oiueinoaeeiia cn?aeaiiy e?ia? ca aeoeaaoe?? o?iiaioeeoa?ii-noaeeiiiai aaiinoaco ? nenoai iaiaiaaeaiiai i?ioaie?co. 4. Iniaeea?noth aieeao oei?enoiai oae?th ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ? ii?ooaiiy o?iia?iiaaiaco ? eiaaoeyoe?? o?a?eiiaaio aiane?aeie iaaei??ii? aeoeaaoe?? o?a?eiie?co. 5. Aieiaieie iniaeeainoyie aieeao oei?enoiai naeioeth ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ? aeoeaaoe?y o?iiaioeeoa?ii-noaeeiiiai aaiinoaco c ?icaeoeii eieaeueii? aioo??oiueinoaeeiii? aaiieiaaoeyoe?? ia ??ai? aeiia?oey?ieo eai?ey??a, ui noi?iaiaeaeo?oueny cia/iei i?eai?/aiiyi oeaieiiiai o?a?eiie?co a e??eia?e ?a/iaei? ie?ie. 6. Caaaeueiith ?enith ae?? aaaeeeo iaoae?a ia cn?aeaiiy e?ia? ? ia?aeiia aeoeaaoe?y o?iiaioeeoa?ii-noaeeiiiai aaiinoaco, c iiaeaeueoith aeoeaaoe?th eiaaoeyoe?eiiai aaiinoaco ? nenoai iaiaiaaeaiiai i?ioaie?co. 7. Noaa?eueiee aiaeia i?inoaoeeee?io II-706 ae?? ia ii/aoeia? aoaie iioeiaeaeaiiy oei?enoeie niieoeaie eaaei?th, oae?th, naeioeth ? ?ooo? nenoaie ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ca ?aooiie i?eai?/aiiy aeoeaiino? o?iiaioeeoa?ii-noaeeiiiai aaiinoaco ? aoi?eiii cieaeo? caaaeueiee aaiieiaaoeyoe?eiee iioaioe?ae oa i?aeaeuo? aioeeiaaoeyoe?eiee iioaioe?ae e?ia?. Oea aeicaiey? aeei?enoiaoaaoe neioaoe/iee aiaeia i?inoaoeeee?io a yeino? i?ioaeoi?a. I?aeoe/i? ?aeiiaiaeaoe??: 1. Ca no/anieo oiia aeieia?/iiai iaaaioaaeaiiy ia i?aai?ci ethaeeie aaaeeeie iaoaeaie aeioe?eueii i?iaiaeeoe ne?ei?iaiaa ianoaaeaiiy nenoaie ?aaoeyoe?? aa?aaaoiiai noaio e?ia?. 2. I?e e?eoaaii? iaoe??io?a c aino?eie ? o?ii?/ieie caoai?thaaiiyie ?aeiiaiaeiaaii aecia/aoe noai o?iiaioeeoa?ii-noaeeiiiai aaiinoaco oa e?eoa??? ae?aaiinoeee noaee?i?/iiai ia?aa?ao neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai cn?aeaiiy e?ia?. 3. A ?ac? anoaiiaeaiiy ii?ooaiue ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ?o ei?aeoe?th ne?ae i?iaiaeeoe c aeei?enoaiiyi oeeoii?ioaeoi??a i?inoaoeeee?iiaiai oeio. Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??. 1. Iiaeieyi N.E. Aieea oei?enoiai naeioeth ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? o a?eeo uo??a // Aoeiaeinueeee iaaee/iee a?niee. – 1998. - ?3-4. – N.131-136. 2. Eooa?/oe I.E., Aiaeia? A.I., Iiaeieyi N.E., Iaaaeyn A.I. Ei?aeoe?y ii?ooaiue ooieoe?? ie?ie i?e ?oooi?e ?ioieneeaoe?? ca aeiiiiiaith aioa?inaaeth // I?iaeaie aeieia?? oa iaaeeoeeie. – 1998. - ?3-4. – N.24. 3. Iiaeieyi N.E. Aieea oei?enoiai oae?th ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? o a?eeo uo??a // Iaoa??aee 2 i?aeia?iaeiiai iaaee/iiai eiia?ano nooaeaio?a ? iieiaeeo a/aieo.- Oa?iii?eue,1998.- N.60-61. 4. Iiaeieyi N.E., Aie/oe O.I. Aieea oei?enoiai eaaei?th ia nenoaio aaiinoaca ? oeaieiiee o?a?eiie?c o a?eeo uo??a // Iaoa??aee 2-ai iaoeiaiai neiiic?oio "Aeieia?/i? i?iaeaie a o??o?a?? oa ?ioeo aaeocyo iaaeeie". - *a?i?aoe?, 1998. - N.71. 5. Eooa?/oe I.E., Iiaeieyi N.E., Ieneeoeueeee A.O. Canoinoaaiiy eaioii?eeo, aeiii?io oa i?aia?aoo II-706 aeey ei?aeoe?? ooieoe?? ie?ie i?e ?oooi?e ?ioieneeaoe?? // Iaoa??aee 2-ai iaoeiaiai neiiic?oio "Aeieia?/i? i?iaeaie a o??o?a?? oa ?ioeo aaeocyo iaaeeie". - *a?i?aoe?, 1998. - N.54. 6. Iiaeieyi N.E. Aieea oei?enoiai oae?th ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? oa oeaieiiee o?a?eiie?c o a?eeo uo??a // Aoeiaeinueeee iaaee/iee a?niee. – 1998.-O.2, ?4.- N.166-172. 7. Eooa?/oe I.E., ?oaeaiei N.N., Aie/oe O.I., Iiaeieyi N.E., Aeiaaaithe E.?., Iaaaeyn A.I., Caaieioia E.A., Ieaiiae/ I.A. Noai caaaeueiiai eiaaoeyoe?eiiai iioaioe?aeo e?ia? ? oeaieiiiai o?a?eiie?co o a?eeo uo??a a ii?i? oa i?e eaaei??a?e ?ioieneeaoe?? // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. - 1999. - ?6.-N.130 -136. 8. Ieneeoeueeee A.O., Iiaeieyi N.E. Iaoieia?/i? ci?ie o?iiaioeeoa?ii-noaeeiiiai oa eiaaoeyoe?eiiai aaiinoaco i?ae aieeaii oei?enoiai naeioeth oa ?o ei?aeoe?y ca aeiiiiiaith neioaoe/iiai aiaeiaa i?inoaoeeee?io // O?c?ieia?/iee aeo?iae. – 1999. – O.45, ?4. – N. 99-104. Iiaeieyi N.E. Aieea oei?enoeo niieoe aaaeeeo iaoae?a (oae?th, eaaei?th, naeioeth oa ?ooo?) ia nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia? oa oeaieiiee o?a?eiie?c. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.03.04 – iaoieia?/ia o?c?ieia?y. – ?inoeooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie, Ee?a, 1999. Anoaiiaeaii, ui noao?ii?/ia ?ioieneeaoe?y oaa?ei oei?enoeie nieyie eaaei?th, oae?th, naeioeth oa ?ooo? aeeeeea? ii?ooaiiy a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? oa oeaieiiiai o?a?eiie?co c ?icaeoeii neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai cn?aeaiiy e?ia?. Ii?ooaiiy aaiinoaco i?e iaoaeioieneeicao ii/eia?oueny c oiene/iiai aieeao ia iaia?aie o?iiaioeeo?a, ui i?ecaiaeeoue aei ca?eueoaiiy ?o aaeaaceaii? oa aa?aaaoe?eii? aeoeaiino?, ca?eueiaiiy ?iaeoeoi??a aa?aaaoe?? ? aoi?eiii? aeoeaaoe?? eiaaoeyoe?eiiai aaiinoaco. Aeiaaaeaii, ui i?aia?ao II-706, yeee ? noaa?eueiei iaaaeiaai?ciaaiei aiaeiaii i?inoaoeeee?io cieaeo? ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a oa ciaioo? a?aenioie aaeaaceaieo o?iiaioeeo?a, ca ?aooiie noaa?e?caoe?? ?o iaa?ai. O ?aa?iiao c oaoiiaaiiei caa?oaeiaiiyi ioi/oth/iai na?aaeiaeua aaaeeeie iaoaeaie i?iiiio?oueny i?iaiaeeoe o ianaeaiiy ui??/ia ianoaaeaiiy noaio nenoaie aaiinoaco c iaoith iiia?aaeaeaiiy ?icaeoeo aeenai?iiaaiiai aioo??oiueinoaeeiiiai cai?oaiiy e?ia?. Iaa?oioiaaia iiaeeea?noue aeei?enoaiiy c iaoith i?io?eaeoeee ii?ooaiue aaiinoaco i?aia?ao?a i?inoaoeeee?iiaiai ?yaeo. Eeth/ia? neiaa: eaaei?e, oae?e, naeiaoeue, ?oooue, aaiinoac, o?a?eiie?c, ei?aeoe?y, i?io?eaeoeea. Iiaeieyi N.E. Aeeyiea oei?enoeo niaaeeiaiee oyaeaeuo iaoaeeia (oaeey, eaaeiey, naeioea e ?oooe) ia nenoaio ?aaoeyoeee aa?aaaoiiai ninoiyiey e?iae e oeaiaaie oea?eiieec. – ?oeiienue. Aeena?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.04 – iaoieiae/aneay oeceieiaey. – Einoeooo oeceieiaee ei. A.A. Aiaiiieueoea IAI Oe?aeiu, Eeaa, 1999. Onoaiiaeaii, /oi noao?iie/aneay eioieneeaoeey aeeaioiuo oei?enouie nieyie eaaeiey, oaeey, naeioea e ?oooe aucuaaao ia?ooaiey a nenoaia ?aaoeyoeee aa?aaaoiiai ninoiyiey e?iae e oeaiaaiai oea?eiieeca n ?acaeoeai neiae?iia aeennaieie?iaaiiiai aioo?eninoaeenoiai naa?ouaaiey e?iae. Ia?ooaiey aaiinoaca i?e iaoaeeioieneeicao ia/eiaaony n oiene/aneiai aeeyiey ia iaia?aiu o?iiaioeeoia, /oi i?eaiaeeo e oaaee/aieth eo aaeaaceaiie e aa?aaaoeeiiiie aeoeaiinoe, inaiaiaeaeaieth eiaeoeoi?ia aa?aaaoeee e aoi?e/iie aeoeaaoeee eiaaoeyoeeiiiiai aaiinoaca.. Iaeua aeicu oei?enouo niaaeeiaiee eaaeiey, oaeey, naeioea e ?oooe nieaeatho aeoeaiinoue i?ioeainaa?ouaathuae nenoaiu e?iae. Onoaiiaeaiu caeiiiia?iinoe aeoeaaoeee iaia?aie/aiiiai i?ioaieeca iiae aeaenoaeai iaeuo aeic oeacaiuo niaieiaiee, a oaeaea iieacaiu iniaaiiinoe eciaiaiee oeaiaaiai oea?eiieeca a aeeciaiii aaaeiuo i?aaiao. Aeieacaii, /oi i?aia?ao II-706, eioi?ue yaeyaony noaaeeueiui iaaaeiaaiece?iaaiiui aiaeiaii i?inoaoeeeeeia nieaeaao eiaeaen niiioaiiie aa?aaaoeee o?iiaioeeoia e oiaiueoaao i?ioeaio aaeaace?iaaiiuo o?iiaioeeoia, ca n/ao noaaeeecaoeee eo iaia?ai. A ?aaeiiao n oaoiiaaiiui caa?yciaieai ie?oaeathuae n?aaeu oyaeaeuie iaoaeaie i?aaeeaaaaony i?iaiaeeoue o ianaeaiey aaeaaiaeiia ianeaaeiaaiea ninoiyiey nenoaiu aaiinoaca n oeaeueth i?aaeoi?aaeaeaiey ?acaeoey aeennaieie?iaaiiiai aioo?eninoaeenoiai naa?ouaaiey e?iae. Iainiiaaia aiciiaeiinoue eniieueciaaiey n oeaeueth i?ioeeaeoeee ia?ooaiee aaiinoaca i?aia?aoia i?inoaoeeeeeiiaiai ?yaea. Eeth/aaua neiaa: eaaeiee, oaeeee, naeiaoe, ?oooue, aaiinoac, oea?eiieec, ei?aeoeey, i?ioeeaeoeea. Podolyan S.K. Influence of heavy metals compounds (thallium, cadmium, lead and mercury) on system of regulation of blood aggregate state and tissue fibrinolysis. - Manuscript. Thesis for obtaining a scientific degree of candidate of medical sciences. Speciality: 14.03.04 - pathological physiology. - Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, 1999. It was established that subchronic intoxication of animals by chlorous compounds of cadmium, thallium, lead and mercury causes disorders in system of regulation of blood aggregate state and tissue fibrinolysis with the development of the syndrome of disseminated intravascular blood coagulation. Disturbance of haemostasis in condition of metallotoxicosis begins with toxic influence on thrombocytics membranes, that leads to increase of theirs adgesiveness and aggregability, platelet release of inductors of aggregation and secondary activation of the coagulative haemostasis. It was proved that subslance MM-706, which is slade nonallogenic, analogues to prostacycline, decreases index of the spontaneous aggregation of the platelets and the percentage of adgesived platelets that can be explained by the membrane stabilization. In the regions with technogenic pollution of environment by heavy metals is proposed to perform annual examination of the hemostasis condition to prevent development of the syndrome of disseminated intravascular blood coagulation in peoples. The possibility of usage of prostacyclin’s medicines is grounded to prevent disorders of haemostasis. Key words: cadmium, thallium, lead, mercury, haemostasis, fibrinolysis, preventive maintenance.

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