.

Вплив хлористих сполук важких металів (талію, свинцю, кадмію, ртуті) на систему регуляції агрегатного стану крові і тканинний фібриноліз (експеримента

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IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE

?INOEOOO O?C?IEIA?? ?IAI? I.I. AIAIIIEUeOess

IIAeIEssI NA?OEAIA EEEI?AIA

OAeE 616.15+616-018-092-06:546.3/8

AIEEA OEI?ENOEO NIIEOE AAAEEEO IAOAE?A (EAAeI?TH, OAE?TH, NAEIOeTH ?
?OOO?) IA NENOAIO ?AAOEssOe?? AA?AAAOIIAI NOAIO E?IA? ? OEAIEIIEE
O?A?EIIE?C

(aenia?eiaioaeueia aeine?aeaeaiiy)

14.03.04 – iaoieia?/ia o?c?ieia?y

AAOI?AOA?AOaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

Ee?a – 1999 ?.

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai??

Iaoeiaee ea??aiee: aeieoi? a?ieia?/ieo iaoe, i?ioani?

Ieneeoeueeee AaeaioeiO?aioeiae/,

caa?aeoaa/ eaoaae?e iaoieia?/ii? o?c?ieia?? Aoeiaei

nueei? aea?aeaaii? iaaee/ii? aeaaeai??

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe

O?aoye Iaoae?y Ieeiea?aia,

Ee?anueeee ?inoeooo aaiaoieia?? ? ia?aeeaaiiy e?ia? IIC
Oe?a?ie,caa?aeoaa/ aaiaoieia?/ii? ee?i?ee aeey aei?ineeo

Eaiaeeaeao iaaee/ieo iaoe

Noaaeea Aaneeue Aiai?eiae/,

IAe? iaaeeoeeie i?aoe? AII Oe?a?ie, caa?aeoaa/ eaai-?aoi???
iaaeeei-a?ieia?/ieo aeine?aeaeaiue.

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.
Aiaiii-

eueoey IIC Oe?a?ie, eaoaae?a iaoieia?/ii? o?c?ieia??,

i. Ee?a

Caoeno a?aeaoaeaoueny “16” eenoiiaaea 1999 ?. i 14 aiaeei? ia
can?aeaii? niaoe?ae?-ciaaiii? a/aii? ?aaee Ae 26.198.01 i?e ?inoeooo?
o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie, 01024, Ee?a-24, aoe.
Aiaiiieueoey, 4.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo o?c?ieia??

?i. I.I.Aiaiiieueoey IAI Oe?a?ie (01024, Ee?a-24, aoe. Aiaiiieueoey, 4.)

Aaoi?aoa?ao ?ic?neaiee “ 15 ” aeiaoiy 1999 ?.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? a?ieia?/ieo iaoe Ni?ie?ia-Ia??ia C.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie.

Ca inoaii? ?iee c?inoa? aeieia?/ia iaaaioaaeaiiy ia i?aai?ci ethaeeie,
ui iaoiiaeaii caa?oaeiaiiyi ioi/oth/iai na?aaeiaeua enaiia?ioeeaie,
cie?aia aaaeeeie iaoaeaie. sseui aino?a io?o?iiy eaaei??i, oae??i,
naeioeai ? ?ooooth ? aeineoue aeia?a aea/aieie, oi ?o o?ii?/ia ae?y ia
i?aai?ci aeine?aeaeaia iaaeinoaoiuei (Aaoeui A.I. e niaao.,1991,
Aeaaeaiei E.E. e niaao., 1997).

A?aeiii, ui ca oiia aeieia?/iiai iaaeaaiiieo//y ?icaeaa?oueny oae caaiee
neiae?ii aia?aiieanoe/iiai aeao?oeeoo. A?i oa?aeoa?eco?oueny cieaeaiiyi
i?ioean?a o?c?ieia?/ii? ?aia?aoe?? oeaiei ? i?ecaiaeeoue aei
iioeiaeaeaiiy aaaaoueio i?aai?a ? nenoai i?aai?cio (Iaiiiiyueo E.I,
Iaiiiiyueo A.E., 1996). Aeiaaaeaii, ui ca inoaii? aeanyoe??//y
ca?eueoo?oueny e?euee?noue o?ii?/ieo caoai?thaaiue c eaoaioiei
ia?aa?aii, c’yaeythoueny iia?, aeieia?/ii iaoiiaeai? oai?iae, ye?
caeaoi? aeinyaaoe noaoono iicieia?/ieo iaeeieoeue (Eoiaeeaa TH.E.,
O?aooaiaa?a E.I.,1991, Aeaaeaiei E.E.e niaao.,1997).

A aaaaoueio aeiaaeeao ee?i?/ii anoaiiaeoe ia?aeiio i?e/eio iaoieia?/iiai
i?ioeano ia aaea?oueny, oiio i?e aeieia?/ii-caeaaeieo caoai?thaaiiyo
canoiniao?oueny ia iaoiaaiaoe/ia, a neiioiiaoe/ia, aai iineiae?iiia
oa?ai?y (Io?iocaiaaoia A., Iie?caeiaa E.,1996). C ?ioiai aieo a?aeiii,
ui ii?ooaiiy aia?aiieanoeee ee?oei caeaaeaoue a?ae noaio
aioo??oiueii?aaiii? i?e?ioee?eoeyoe??, yea, a naith /a?ao, iaoiiaeaia
?aieia?/ieie aeanoeainoyie e?ia? (Aiae?aaiei A.A.,1979, Aiae?aaiei A.A.e
niaao.,1981, A?oaiiiia A.N.e niaao.,1993). Inoaii? o?nii iia’ycai? c
nenoaiith ?aaoeyoe?? aa?aaaoiiai noaio e?ia? ? oeaieiiei o?a?eiie?cii
(Aa?eaaai C.N.,1980). Iaeiae, c oi/ee ci?o ?icaeoeo aeieia?/ii-caeaaeii?
iaoieia??, ieoaiiy ci?i a nenoaiao eiaaoeyoe?eiiai,
o?iiaioeeoa?ii-noaeeiiiai aaiinoaco, i?ioecn?aeath/i? ? o?a?eiie?oe/ii?
nenoai, iaiaiaaeaiiai i?ioaie?co, a oaeiae oeaieiiiai o?a?eiie?co
aea/ai? iaaeinoaoiuei.

Iaoa aeine?aeaeaiiy iieyaaea o ?ic?iaoe? niinia?a iaoiaaiaoe/ii?
ei?aeoe?? ii?ooaiue o nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?ae
aieeaii iaeeo aeic oei?enoeo niieoe aaaeeeo iaoae?a (eaaei?th, naeioeth,
oae?th ? ?ooo?).

Aeey aeinyaiaiiy iaoe ?iaioe iio??aii aoei ae??oeoe ianooii? caaaeaiiy:

– aea/eoe aieea iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth
oa ?ooo? ia o?iiaioeeoa?ii-noaeeiiee ? eiaaoeyoe?eiee aaiinoac a
noao?ii?/iiio aenia?eiaio?;

– aeine?aeeoe ci?ie iaiaiaaeaiiai i?ioaie?co, i?ioecn?aeath/i? ?
o?a?eiie?oe/ii? nenoai i?ae o?ii?/iei aieeaii iaeeo aeic oei?enoeo
niieoe eaaei?th, oae?th, naeioeth ? ?ooo?;

– aeyaeoe ii?ooaiiy oeaieiiiai o?a?eiie?co a aeeoo?ai aaaeeeaeo i?aaiao
(aieiaiee iicie, na?oea, eaaai?, ia/?iea, ie?ee) i?e noao?ii?/iiio
aieea? ia i?aai?ci iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th,
naeioeth oa ?ooo?;

– a iiaeaeueieo aenia?eiaioao in vitro anoaiiaeoe caaaeuei? iaoai?cie
ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?ae aieeaii
iaeeo aeic aaaeeeo iaoae?a;

– iaoiaaiaoe/ii iaa?oiooaaoe ? ?ic?iaeoe niiniae ei?aeoe?? anoaiiaeaieo
ii?ooaiue ?aaoeyoe?? aa?aaaoiiai noaio e?ia?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa anoaiiaeaii, ui caaaeueiith caeiiii??i?noth o?ii?/iiai aieeao ia
i?aai?ci iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth ? ?ooo?
? ia?aeiia aeoeaaoe?y o?iaioeeoa?ii-noaeeiiiai aaiinoaco oa c’yniaaii,
ui ci?ie eiaaoeyoe?eiiai aaiinoaco i?e o?ii?/i?e ?ioieneeaoe?? aaaeeeie
iaoaeaie iathoue aoi?eiiee oa?aeoa?. Oea iaoiiaeaii ?icaeoeii
aioo??oiueinoaeeiii? aaiieiaaoeyoe?? ? aaeueioaaiiyi o?a?eiiaaiaco i?ae
aieeaii ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o, aai i?iaeoeo?a
aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio.

Aia?oa anoaiiaeaii, ui iae? aeice oei?enoeo niieoe eaaei?th, oae?th,
naeioeth ? ?ooo? caeiiii??ii cieaeothoue aeoeai?noue i?ioecn?aeath/i?
nenoaie e?ia? ? aeiaaaeaii, ui i?e o?ii?/i?e ?ioieneeaoe?? iaeeie
aeicaie oei?enoeo niieoe naeioeth ? oae?th iiaeeeai ia? i?noea
a?eo?ioeeoa?iee eiiiiiaio aeoeaaoe?? ia?aeiiiai aaiinoaco.

Aia?oa aeyaeaii caeiiii??i?noue aeoeaaoe?? iaiaiaaeaiiai i?ioaie?co i?ae
aieeaii iaeeo aeic oei?enoeo niieoe eaaei?th, oae?th, naeioeth ? ?ooo?
oa iieacaii iniaeeaino? ci?i oeaieiiiai o?a?eiie?co a aeeoo?ai
aaaeeeaeo i?aaiao i?ae aieeaii iaeeo aeic oei?enoeo niieoe eaaei?th,
oae?th, naeioeth ? ?ooo?.

Aia?oa ?ic?iaeaiee iaoiaaiaoe/ii iaa?oioiaaiee niin?a ei?aeoe??
ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? i?e o?ii?/i?e
?ioieneeaoe?? aaaeeeie iaoaeaie ca aeiiiiiaith noaa?eueiiai aiaeiao
i?inoaoeeee?io — i?aia?aoo II-706.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

A ?acoeueoao? i?iaaaeaiiai aeine?aeaeaiiy anoaiiaeai? caaaeuei?
caeiiii??iino? oiene/iiai aieeao oei?enoeo niieoe aaaeeeo iaoae?a ia
nenoaio ?aaoeyoe?? aa?aaaoiiai noaio e?ia?, ui a?aee?eaa? iiaeeeaino?
ee?i?/ii? ai?iaaoe?? a aeieia?/ii caa?oaeiaieo ?aa?iiao Oe?a?ie iiaeo
iaoiae?a e?eoaaiiy oai?ia, ye? noi?iaiaeaeothoueny ii?ooaiiyie
?aieia?/ieo aeanoeainoae e?ia? aiane?aeie ?icaeoeo noaee?i?/ieo oi?i
aioo??oiueinoaeeiii? aaiieiaaoeyoe??.

Aenia?eiaioaeueia iaa?oiooaaiiy aoaeoeaiino? i?aia?aoo II-706 a?aee?eaa?
ia?niaeoeae aeey ee?i?/ii? ai?iaaoe?? iiaeo iaoiae?a i?io?eaeoeee oa
e?eoaaiiy o?ii?/ieo ?ioieneeaoe?e aaaeeeie iaoaeaie ?c canoinoaaiiyi
noaa?eueiiai aiaeiaa i?inoaoeeee?io.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo.

?acoeueoaoe ?iaioe ai?iaaaeaeai? a iaa/aeueiee i?ioean ia eaoaae?ao
iaoieia?/ii? o?c?ieia?? Euea?anueeiai, Aeiiaoeueeiai, Eoaainueeiai,
Oa?e?anueeiai aea?aeaaieo iaaee/ieo oi?aa?neoao?a, Oa?iii?euenueei?
iaaee/ii? aeaaeai??, IAe? iaaeeei-aeieia?/ieo i?iaeai (i. *a?i?aoe?) a
oaeiae ia eaoaae?ao oa?iaeieia?? ? iaaee/ii? o?i?? Aoeiaeinueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (i.*a?i?aoe?).

Iniaenoee aianie caeiaoaa/a.

Aeena?oaioii naiino?eii aeeiiai? an? aenia?eiaioaeuei? aeine?aeaeaiiy,
i?iaaaeaii aiae?c io?eiaieo aeaieo, iaienai? an? ?icae?ee
aeena?oaoe?eii? ?iaioe, noi?ioeueiaai? aeniiaee ? i?aeoe/i?
?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

I?i iniiai? io?eiai? aeai? aeiiia?aeaeiny ia iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeuei? ieoaiiy ee?i?/ii? iaaeeoeeie oa aeieia??”
(Iieoaaa, 1998) I?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo
a/aieo (Oa?iii?eue, 1998), i?aenoieiaeo iaoeiaeo eiioa?aioe?yo
ni?a?ia?oiee?a Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeai?? (*a?i?aoe?,
1996, 1997, 1998).

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o ye? a?aeia?aaeothoue ??
iniiai? iieiaeaiiy, c ieo 5 o oaoiaeo iaoeiaeo aeo?iaeao, 3 – a
iaoa??aeao ? oacao eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??.

?iaioa neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, iienaiiy iaoa??ae?a
oa iaoiae?a aeine?aeaeaiiy, 5 ?icae?e?a aeanieo aeine?aeaeaiue,
iaaiai?aiiy io?eiaieo aeaieo, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e oa
iieaae/eea e?oa?aoo?e. Aeena?oaoe?y aeeeaaeaia ia 178 noi??ieao
iaoeiiieniiai oaenoo, ?ethno?iaaia 34 oaaeeoeyie ? 35 ?enoieaie.
A?ae?ia?ao?y aeeth/a? 289 e?oa?aoo?ieo aeaea?aea, c ieo 109 – ?iicaiieo
aaoi??a.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Aeey ae??oaiiy iinoaaeaieo caaaeaiue aoee i?iaaaeai? na??? aenia?eiaio?a
in vitro oa in vivo. A ?iaio? aeei?enoaii 300 naioe?a oa naiie a?eeo
uo??a c ianith o?ea 0,1530,018 ea. Oei?eno? niieoee eaaei?th, oae?th,
naeioeth oa ?ooo? aaiaeeee aioo??oiueioeoieiai, uiaeaiii, iaoaeaaei
ciiaeii a aeicao aeey CdCl2, HgCl2 ii 0,05 ia/ea, aeey PbCl2, TlCl – ii
0,5 ia/ea iane o?ea. Aeine?aeaeaiiy i?iaiaeeee /a?ac 2 oeaei? i?ney
aaaaeaiiy oei?enoeo niieoe aaaeeeo iaoae?a.

E?ia caae?aee c /a?aaii? ai?oe nee?eiiiaaiei oi?eoeai, i?ae iaiaooaeiaei
ia?eicii (40 ia/ea iane o?ea), noaa?e?coaaee oeeo?aoii iao??th,
oeaio?eooaoaaee ? a?aeie?aiethaaee ieacio a?ae oi?iaiieo aeaiaio?a.
A?ae?aco i?ney aaoaiac?? uo??a iaaaaeee aioo??oi?o i?aai?a (ie?ee,
na?oea, ia/?ieo, aieiaiee iicie ? eaaai?) caii?iaeoaaee o ??aeeiio acio?
aeey iiaeaeueoeo a?io?i?/ieo aeine?aeaeaiue.

Noai o?iiaioeeoa?ii-noaeeiiiai aaiinoaco ioe?ithaaee ca a?aenioeii
aaeaaceaieo o?iiaioeeo?a (A.I. Ieuaiei e ae?., 1980), a oaeiae ca
?iaeaenii niiioaiii? aa?aaaoe?? o?iiaioeeo?a (A. Tacolla et al., 1980).
Caaaeueiee eiaaoeyoe?eiee iioaioe?ae e?ia?, iioaioe?eio aeoeai?noue
ieaci?iiaaio, aioeieaci?ie, ??aaiue o?a?eiiaaio a ieaci? e?ia?,
aeoeai?noue aioeo?iia?io III, o?a?einoaa?e?coth/iai oaeoi?o,
eiioeaio?aoe?th ?ic/eiieo eiiieaen?a o?a?ei-iiiiia?o oa i?iaeoeo?a
aeaa?aaeaoe?? o?a?ei/o?a?eiiaaio, a oaeiae o?ie?iacio aeoeai?noue na/?
aecia/aee ca aeiiiiiaith iaai??a ?aaeoea?a o??ie “Simko Ltd.” (Euea?a).

E??i oiai, c aeei?enoaiiyi ?aaeoea?a oe??? o??ie aecia/aee
oa?iaioaoeaiee ? iaoa?iaioaoeaiee o?a?eiie?c a na/?, ieaci? e?ia? ?
oeaiei aioo??oi?o i?aai?a. I?eioeei iaoiaeo iieyaa? a oiio, ui i?e
?ieoaaoe?? acio?a?eio ?c noaiaea?oiith e?euee?noth ieaci?iiaaio a
i?enooiino? aeoeaaoi??a o?a?eiie?co, ye? i?noyoueny a na/?, ieaci? e?ia?
aai a oeaieiao, ooai?th?oueny ieaci?i, aeoeai?noue yeiai ioe?ith?oueny
ca nooiaiai caaa?aeaiiy ?ic/eio a eoaeiiio na?aaeiaeu?, aiane?aeie
e?ceno acio?a?eio, a i?enooiino? -ai?iieai?iiiai? eeneioe
(iaoa?iaioaoeaiee o?a?eiie?c), aai aac ia? (noia?ia o?a?eiie?oe/ia
aeoeai?noue). ??cieoey i?ae ieie a?aeaeca?eaeth? noai oa?iaioaoeaiiai
o?a?eiie?co. Ca aiaeia?/iei iaoiaeii aecia/aee i?ioaie?oe/io
aeoeai?noue, aeei?enoiaoth/e aciaeueaoi?i, acieaca?i oa acieie.

A na??? iiaeaeueieo aenia?eiaio?a aeei?enoiaoaaee 2 ii?oe?? oe?eueii?
oeeo?aoii? e?ia?: aei ia?oi? i?ia??ee aeiaeaaaee 0,1 ie ?cioii?/iiai
oei?enoiai iao??th, aei ae?oai? – 0,1 ie ?ic/eio oei?enoeo niieoe
eaaei?th, oae?th, naeioeth aai ?ooo? a e?ioeaa?e eiioeaio?aoe?? 10
ia/ie. I?ney 30 oaeeei ?ieoaaoe?? o aiaeyiiio oa?iinoao? i?e oaiia?aoo??
37iN caienoaaee o?iiaiaeanoia?aie.

Ei?aeoe?th ii?ooaiue a nenoai? ?aaoeyoe?? aa?aaaoiiai noaio e?ia? a
aenia?eiaio? i?iaiaeeee ca aeiiiiiaith i?aia?aoa “II-706” – noaa?eueiiai
aiaeiaa i?inoaoeeee?io, neioaciaaiiai a ?inoeooo? o?i?? Anoiinueei? AI.
I?aia?ao aaiaeeee uo?ai ca 30 oa ia?aae aaoaiac??th,
aioo??oiueii/a?aaaiii, o aeic? 0,56 ia/ea.

Noaoenoe/ia ia?iaea io?eiaieo aeaieo i?iaaaeaia ia PC Pentuim II ca
aeiiiiiaith “Microsoft Excel 7.0” ? i?ia?aie “Statgraphics” (NOA). A
oaaeeoeyo cia/aiiy “?” iaaaaeai? eeoa aeey a??ia?aeieo (?=0,05 aai
iaioa) ??cieoeue iieaciee?a, ui aea/aeeny.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy

Coao?ii?/ia aaeeaaiiy oaa?eiaie iaeeo aeic oei?enoiai eaaei?th
i?ecaiaeeei aei aeoeaaoe?? ia?aeiiiai aaiinoaco (?en. 1) i?e
iiaeiaaeaii? /aniaeo oa?aeoa?enoee cn?aeaiiy e?ia? (?en. 2).

?en. 1 Aieea oei?enoiai eaaei?th ia aaeaaceaii-aa?aaaoe?eio caeaoi?noue
o?iiaioeeo?a (a % a?ae eiio?ieth)

?NAO – ?iaeaen niiioaiii? aa?aaaoe?? o?iiaioeeo?a

IAO – i?ioeaio aaeaaceaieo o?iiaioeeo?a

?en. 2 Aieea oei?enoiai eaaei?th ia /ania? oa?aeoa?enoeee caaaeueiiai
iioaioe?aeo cn?aeaiiy e?ia? (a % a?ae eiio?ieth)

AIO* – aeoeaiaaiee ia?oe?aeueiee o?iiaiieanoeiiaee /an

I?ioecn?aeath/ee iioaioe?ae e?ia? ciaiooaaany, I?i oea na?ae/eei
cieaeaiiy aeoeaiino? aioeo?iia?io ??? c 115,600,95% a eiio?ie? aei
100,701,35% a aeine?ae? (p

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