I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEA IAAeE*IA NOIIAOIEIA?*IA AEAAeAI?ss

Ia i?aaao ?oeiieno

Eo/a?aiei Ieaenaiae? Ieeieaeiae/

OAeE [616.314 — 002 —
002/07-085: 576.8.095.323.22] — 053.4/5

AIEEA AIOEAAEOA?IAEUeIEO CANIAIA IA EA???NIAAIII AEANOEAINOI COAIIAI
IAEUeIOO

14.01.220noiiaoieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Iieoaaa 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai??,
ia eaoaae?? aeeoy/i? noiiaoieia?? (?aeoi? — aeaaeai?e AII Oe?a?ie,
i?ioani? A.A. Aecye)

Iaoeiaee ea??aiee: — aeieoi? iaaee/ieo iaoe, i?ioani?

Aee/ei ?aaai Ieeeoi?iae/, caa?aeoaa/ eaoaae?e

aeeoy/i? noiiaoieia?? AeAeIA;

Io?oe??ei? iiiiaioe: — aeieoi? iaaee/ieo iaoe, i?ioani?

Iaaeaeea ?aai Iiaianiae/, caa?aeoaa/ eaoaae?e

aeeoy/i? noiiaoieia?? OINA,

niaoe?aeuei?noue 14.01.22 — noiiaoieia?y;

eaiaeeaeao iaaee/ieo iaoe, aeioeaio *eaeaanueeee

?aai Aieiaeeie?iae/, caa?aeoaa/ eaoaae?e

aeeoy/i? noiiaoieia?? AeAeIO,

niaoe?aeuei?noue 14.01.22 — noiiaoieia?y

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe,

eaoaae?a oa?aiaaoe/ii? noiiaoieia?? c eo?nii aeeoy/i? noiiaoieia??.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 24.11 1998?ieo i 14 aiae. ia
can?aeaii? Niaoe?ae?ciaaii? a/aii? ?aaee Ae44.601.01 17 i?e Oe?a?inuee?e
iaaee/i?e noiiaoieia?/i?e aeaaeai?? 314024, i. Iieoaaa, aoe Oaa/aiea,
23.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oe?a?inueei?
iaaee/ii? noiiaoieia?/ii? aeaaeai??.

Aaoi?aoa?ao ?ic?neaiee 25 aa?aniy 1998

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee

eaiae. iaae. iaoe

aeioeaio I.A. Aieiaei

Caaaeueia oa?aeoa?enoeea ?iaioe

AEOOAEUeIINOUe OAIE. Ic /eneaiieo i?iaeai no/anii? noiiaoieiai?
iaeaieueo nooo?aei i cia/eiei caa?iaa?oueny ieoaiiy naiiai iioe?aiiai
na?aae ianaeaiiy caoai?thaaiiy — ea?i?no coaia. Iaoeiai aeineiaeaeaiiy a
cia/iie ii?i aeicaieeee ?ice?eoe eiai aoiieiaith i iaoiaaiaoe/i? eaiee,
iaa?oiooaaoe aeiaaiinoeeo i no/ani? eieoaaeuei? caoiaee, a oaeiae
iaoiaee ei?aeoe?? ia aoaiao iiia?aaeaeaiiy. I?ioa aeai? iii?oi?eia?a
na?ae/aoue, ui aeniea iioe?ai?noue ? ?ioaineai?noue ea???no, iaaeaeue,
caa??aa?oueny ye o aei?ineeo, oae ? iniaeeai o ae?oae (O. O.
Aeiia?aaeiaa,1988; I. A. Oaeiaeoeueea, A. I. Iani?yaeueei,1989; E. I.
Oiiaiei i niiaaao,1993). Iiae?aia neooaoe?y coiiaeaia oe?eith ieceith
oaeoi??a, ye? a inoaii? ?iee iaaoaathoue ana a?eueoiai ?icaeoeo.
Iia??oaiiy iaoa??aeueiiai noaio cia/ii? /anoeie ianaeaiiy, iaiaaeaiiy a
oa?aeoa?? oa?/oaaiiy, eiai iacaaeainiaai?noue oa iaaei??ia aaeeaaiiy
?ao?iiaaieo aoaeaaiae?a, o?eaae? no?ane oa iia??oaiiy niiaoe/iiai
caei?ia’y ae?oae i?eaiaeyoue aei c??noo iieaciee?a caoai?thaaiiy ia
ea???n (A. I. Aa?aaa i niiaaao, 1984; A. I. Aaeaiia, 1988; I. I. Aaoeei
i niiaaao, 1991). Ie??i oiai, iaaaoeai? oaeoi?e iaaeieeoiueiai
na?aaeiaeua noathoue aai /eiieeaie, aai oiiaaie, ui i?aeo?eiothoue
?icaeoie oe??? iaoieia?? (A. I. Caiianueeee, 1985; I. I. Ai?cia, 1989;
I. I. Niiey? i niiaaao, 1994).

Aeoiaey/e ic cia/eiinoi aeieieioe/ii? oai?i? ea?iiciiai i?ioeano, neiae
aeciaoe i?iaiaeio ?ieue iie?ii?aaiiciia coaiiai iaeueioo, eio?i
i?iaeoeoaie aeeoo?aeiyeueiinoi i?iaieothoue aeaiiia?aeicaoeith aiaei (?.
A. Ai?ianueeee i niiaaao, 1985). I?e oeueiio iiaee?aneth?oueny
cia/eiinoue ea???niaaiii? aeoeaiinoi aaeoa?ie ?iaeo Streptoninnus,
iniaeeai Str. mutans, yei ca nai?ie oa?aeoa?ieiai/ieie yeinoyie caeaoii
i?eeiaoe o/anoue a caioneo iaoaiicio ea???no (n. n. Ieaeiee i niiaaao,
1986).

Aeineiaeaeaiiy iieacaee, ui iaeaieueo /ooeeaith aei aeaiiia?aeicaoe?? ?
aiaeue oei/aniaeo i iinoieieo coa?a, ye? ciaoiaeyoueny a oaci
aeic?iaaiiy a ia?o? ?iee iiney ?o i?i?icoaaiiy. Naia a oeae /an
?acenoaioiinoue oaa?aeeo oeaiei aei ea???no ?icei cieaeaia (A. E.
Eaiio’?a, 1986). ? naia a oeae ia??iae iaea?eueo /?oei aeyaeythoueny
«neaaei» ciie aiaei, ye? i?aeaeaoi? ea???no (I. A. Aa?aiieeiaa, 1978, A.
I. Iaoiiia, 1986). Iaaeineiiaea no?oeoo?a aiaei eaaei iiaeaea?oueny ae??
i?iaeoeoia aeeoo?aeiyeueiinoi eeneioiooai?thth/eo aaeoa?ie, a oiio /enei
iiei/ii? eeneioe, eio?o ae?iaeythoue no?aioieiee i eaeoiaaeoa??? (E. A.
Ii?iciaa,1970).

Iniaeeai a?aceeaee aie aeioae a ciiiiiio i?eeoni ia i?ioyci aeaio ?ieia
c iiiaioo i?i?icoaaiiy coaia. A oeae ia?iiae niinoa?iaa?oueny cia/ia
caieueoaiiy /enea oei/aniaeo ea?iicieo coaia o aeioae i, ye ianeiaeie,
iiaeaeuaiiy caniao ii?iaeieie ?ioa ea???niaaiieie aaeoa?iyie. Aeciath/e
i?iaiaeia cia/aiiy eeneioiooai?thth/eo aaeoa?ie coaiiai iaeueioo o
aeieeiaiii ea???no, ia aeeeeea? noiiiao aeioeieueiinoue aeei?enoaiiy
aioeaaeoa?iaeueieo caniaia a iiia?aaeaeoaaeueieo caoiaeao. Ca aeaieie
eioa?aoo?e oaaaa aei aioeaaeoa?iaeueii? noiiaoieiai/ii? i?ioieaeoeee
iieiee ia caoeoaea, a iioaineaiee iiooe a oeueiio iai?yieo iinoieii
i?iaiaeeoueny, oae ye eiioeaai ?acoeueoaoe ia caaaeaee iiaiinoth
caaeiaieueiythoue i iiaeeeai oneeaaeiaiiy, iia’ycaii c iaaeeeaiaioiciith
ae??th o ii?iaeieii ?ioa.

Io?eiaiee aeinoaoiie ye iiceoeaiee oae ? iaaaoeaiee aeinaiae
i?ioeea?iiciiai aeei?enoaiiy aioeaiioeeia, oa?iaioia,
iiaa?oiaai-aeoeaieo ?a/iaei, ooi?eaeia oa iioeo caniaia.

Iiooe iaeaieueo aeineiiaeeo aioeaaeoa?iaeueieo i?aia?aoia, ?o
eiiaiiaoeie i niiniaia aeei?enoaiiy a i?aaaioeaiie noiiaoieia??
aeeoy/iai aieo ia? aino?o aeooaeueiinoue i a ieiioiie /an, iniaeeai c
iiceoeie caa?aaeaiiy i?e?iaeiiai aiioeaiico ii?iaeieie ?ioa aeeoeie.

Ca’ycie ?iaioe

c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Aeena?oaoe?eia ?iaioa ? o?aaiaioii ieaiiai? iaoeiai? oaie eaoaae?e
aeeoy/i? noiiaoieia?? Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii?
aeaaeai?? «?ic?iaea oa oaeineiiaeaiiy iaoiae?a e?eoaaiiy, i?io?eaeoeee ?
?aaa?e?oaoe?? i?e noiiaoieia?/ieo caoai?thaaiiyo o ae?oae, ui iaoeathoue
a oiiaao ?ioaineaii? i?iieneiai? ciie». ? aea?aeaaii? ?a?no?aoe??
01.89.0008873.

IAOA AeINEIAeAEAIIss. Iaoith aeineiaeaeaiiy ? iiaeaeuaiiy aoaeoeaiinoi
i?ioieaeoeee ea???no o aeioae a ia?iiae ciiiiiai i?eeono c aeei?enoaiiyi
aioeaaeoa?iaeueieo caniaia oo?aa?ia oa A-aaeoa?eia o eiiieaen?.

CAAeA*I AeINEIAeAEAIIss

1. Aea/eoe iioe?aiinoue oa iioaineaiinoue ea???no coaia o aeioae o aioei
5-10 ?ieia, ui iaoeathoue a oiiaao i?iieneiaiai I?eaeiii?ia’y.

2. Aea/eoe eieueeiniee oa yeiniee neeaae iie?ioei?e coaiiai iaeueioo o
aeioae eiio?ieueii? oa aeineiaeieo a?oi.

3. Aea/eoe in vitro aoaeoeaiinoue aioeaaeoa?iaeueii? ae?? ia iie?iaio
oei?o coaiiai iaeueioo i?e aeei?enoaiii oo?aaiio ?ic/eiiiai oa
A-aaeoa?eio o eiiieaeni.

4. Aea/eoe aieea cai?iiiiiaaieo aioeaaeoa??aeueieo i?aia?ao?a ia i?e??no
?ioaineaiino? ea???no o aeioae a?eii 5-10 ?ie?a oa anoaiiaeoe
a?aenooi?noue iaaaoeaieo iane?aee?a aeei?enoaiiy eiiieaeno oo?aa?io oa
A-aaeoa?eio a ii?iaeiei? ?ioa.

5. Cai?iaaaeeoe a i?aeoeeo aeeoy/i? noiiaoieia?? aoaeoeaiee cania
aioeaaeoa?iaeueii? i?ioieaeoeee c aeei?enoaiiyi oo?aa?io oa A-aaeoa?eio.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAOIA

Io?eiai? iia? aeai? noiniaii /anoioe ea???no coa?a o ae?oae a?eii a?ae
5 aei 10 ?ie?a, ui iaoeathoue a neeaaeieo aeieia?/ieo oiiaao
I?eaei?i?ia’y.

Aia?oa aeyaeaia iniaeea?noue can?ao ea???niaaiiith i?e?ioei?ith coaiiai
iaeueioo niinoa??aa?ieo ae?oae aeaiiai ?aa?iio, anoaiiaeaiee ??
e?euee?niee oa ye?niee neeaae.

Aeiaaaeaia ?ieue Aerococcus viridans, ye i?aaenoaaieea ii?iaeueii?
i?e?ioei?e i?aai?cio, a iaeo?ae?caoe?? iiei/ii? eeneioe, yea
ae?iaey?oueny Str. mutans.

Aeiaaaeaia aeniea aioeaaeoa??aeueia ae?y eiiieaeno oo?aa?io oa
A-aaeoa?eio in vitro ia i?e?ioei?o coaiiai iaeueioo o ae?oae, ye?
iaoeathoue a I?eaei?i?ia’?.

I?aeoaa?aeaeaii i?eiouaiiy, ui eiiieaenia aeei?enoaiiy a ee?i?oe?
oo?aa?io ?ic/eiiiai oa A-aaeoa?eio aieiae?? aenieith i?ioeea??iciith
aoaeoeai?noth.

?ic?iaeaiee aoaeoeaiee i?io?eaeoe/iee can?a aeei?enoaiiy oo?aa?io oa
A-aaeoa?eio i?e ea???niaaii?e neooaoe?? o ae?oae a ia??iae ci?iiiai
i?eeono oa aeic??aaii? aiae? iino?eieo coa?a.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAOIA

Aeei?enoaiiy io?eiaieo aeaieo ii caoai?thaaiino? ia ea???n oa nooiaiy
can?ao i?e?ii?aai?ciaie coaiiai iaeueioo o ae?oae I?eaei?i?ia’y
aeicaiey? ieaioaaoe ianya e?eoaaeueieo oa i?io?eaeoe/ieo caoiae?a o
oeueiio ?aa?ii?. Canoinoaaiiy cai?iiiiiaaiiai aioeaaeoa??aeueiiai
eiiieaeno i?e i?iaaaeaii? i?io?eaeoe/ieo caoiae?a cieceoue i?e??no
?ioaineaiino? ea???no oaea?/? ? aeanoue cia/iee aeiiii?/iee aoaeo.

INIAENOEE AIANIE CAeIAOAA*A O ?IC?IAEO IAOEIAEO ?ACOEUeOAO?A, UI
AEIINssOUeNss IA CAOENO

Aeena?oaoeieia ?iaioa yaey? niaith naiinoieia iaoeiaa aeineiaeaeaiiy.
Aeeiiaia a oiiaao eaoaae? aeeoy/i? noiiaoieia?? oa iie?iaiieia??
Aeiii?iiao?ianueei? iaaee/ii? aeaaeai??.

Ani iieiaeaiiy, ui aeiinyoueny aei ioioeieiiai caoenoo, ?ic?iaeaii
aaoi?ii naiinoieii, ye i aeiai? eeiii/iiai iaoa?iaeo, i?iaaaeaiiy
eaai?aoi?ieo i eeiii/ieo aeineiaeaeaiue, aiaeic ?acoeueoaoia
aeineiaeaeaiiy.

Noaoenoe/ia ia?iaea io?eiaieo ?acoeueoaoia i oeoia/aiiy ?acoeueoaoia
eeiiiei-eaai?aoi?ieo aeineiaeaeaiue i?iaaaeaii naiinoieii.

AI?IAAOeIss ?ACOEUeOAO?A AeENA?OAOe??

Iaoa?iaee aeena?oaoe?? aeeeaaeaii oa iaaiai?aii ia iiaenoieiaeo
iaoeiai-i?aeoe/ieo eiioa?aioeiyo Aeiii?iiao?ianueei? iaaee/ii? aeaaeai??
(1993 — 1997 ), caniaeaiii iaeaniiai iaoeiai-i?aeoe/iiai oiaa?enoaa
noiiaoieiaia (1993 — 1997). Iniiaii iieiaeaiiy i?aoei i?aaenoaaeaii a
ae?oeiaaieo noaooyo. Aeena?oaoeieia ?iaioa i?ieoea ai?iaaoeith ia
?icoe?aiiio caniaeaiii AeAeIA o aeiaoi? 1997 ?ieo, oa OINA o n?/i? 1998
?ieo.

IOAEIEAOeI?

Ca oaiith aeena?oaoe?? iioaeieiaaii 6 ?iaio, o?e c yeeo — o iaoeiaeo
oaoiaeo aeaeaiiyo.

AI?IAAAeAEAIIss A I?AEOEEO

Iaoa?iaee aeena?oaoe?? ai?iaaaeaeaii a eieoaaeueii-i?ioieaeoe/ieo
caeeaaeao aeeoy/iai i?ioieth i.i. Aeiii?iiao?ianueea, Iiaiiineianueea,
E?eaiai ?iao, a o/aiaee i?ioean noiiaoieiai/iiai oaeoeueoaoo
Aeiii?iiao?ianueei? iaaee/ii? aeaaeai??.

NO?OEOO?A OA IANssA AeENA?OAOe?EII? ?IAIOE

Aeena?oaoeiy neeaaea?oueny ic anooio, iaeyaeo eioa?aoo?e, iaoa?iaeo oa
iaoiaeee aeineiaeaeaiiy, ?acoeueoaoia aenia?eiaioaeueieo oa eeiii/ieo
aeineiaeaeaiue, caeeth/aiiy, aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoeie,
nieneo eioa?aoo?e (anueiai 125 noi?iiie iaoeiiieno). ?iaioa iethno?iaaia
29 oaaeeoeyie. Aiaeiia?aoiy aeeth/a? 256 aeaea?ae, c yeeo 155
aio/eciyieo oa 101 ?iicaiieo aaoi??a.

IAOA??AEE OA IAOIAeE AeINEIAeAEAIIss

Ae?ioaiiy iinoaaeaieo caaea/ caeienithaaeinue a eeiii/iiio aenia?eiaioi
oa a eeiiioei c aeei?enoaiiyi eiiieaeno eeiiiei-eaai?aoi?ieo,
aiioiii/ieo oa iie?iaiieiai/ieo iaoiaeia aeineiaeaeaiiy.

Ia’?eoaie aeineiaeaeaiiy noaee aeioe aeioeieueiiai oa iieiaeoiai
oeieueiiai aieo, yei c aeiy ia?iaeaeaiiy iinoieii iaoeaee a oiiaao
aaeeeiai i?iieneiaiai iinoa oa ciaoiaeeeenue a aaeaeaaoieo aeieiai/ieo
oa nioeiaeueieo oiiaao. Anueiai aoei ianoaaeaii 1205 aeioae o aioei aiae
5 aei 10 ?ieia. A caeaaeiinoi aiae aeei?enoaiiy i?ioieaeoe/ieo caoiaeia
aeioe aoee ?iciiaeieaii ia /ioe?e i?eaeecii ?iaii ii eieueeinoi a?oie.
Ie?ii oiai, 33 aeeoeie aoee aeaeieaii a a?oio aeey niinoa?aaeaiiy i
caeieniaiiy caaaeueiiaia??ii/ieo iaae/ie, a oaeiae aeey aecia/aiiy
iieacieeia, oa?aeoa?ieo aeey caei?iaeo aeioae. Aeey c?noaaeaiiy ai?noo
Aerococcus viridans a coaiiio iaeueio? aoee iaeii?aciai ianoaaeai? 35
ae?oae aeieia?/ii /enoiai ?aeiio I?eaei?i?ia’y.

Iaeiae a aeaoaeueiee aiaeic ii iniiaiei iaoiaeeeai aeineiaeaeaiiy oa
?acoeueoaoia ae?? i?ioieaeoe/ieo caoiaeia ia ea???niaaiii aeanoeainoi
coaiiai iaeueioo c eiaeii? a?oie aaeeeiai ianeao aeioae aoei acyoi ia
iaio, i?ae 33 iniae aeey cinoaaeaiiy yeinoae i?aia?aoia, ui aea/aeeny,
iaoiaeia i?ioieaeoe/ii? ae??, aieueo aeeaieiai aiaeico io?eiaieo aeaieo.

Io?eiaii ?acoeueoaoe caiineeeny a ?ic?iaeaio ea?oo noiiaoieiai/ieo
aeineiaeaeaiue.

Noiiaoieiai/ia aeineiaeaeaiiy i?iaiaeeeinue ca ?aeiiaiaeaoeiyie AIIC (?.
A. Ai?ianueeee, I. A. Eaon, 1985).

Aecia/aeanue iioe?aiinoue oa iioaineaiinoue ea?iiciiai i?ioeano, i?e?ino
?ioaineaiino? ea???no. Aeey ioeiiee aia??ii/iiai noaio ii?iaeieie ?ioa
aeei?enoiaoaaany iiaeaen Oaaei?iaa i Aieiaeeiii? (1971). Aeey ioeiiee
nooiaiy c?ieinoi aiaei oa no?oeoo?ii-ooieoeiiiaeueii?
ea???n?acenoaioiinoi aoa aeei?enoaiee i?enei?aiee OA? (A. ?. Ieooei i
niiaaao, 1989).

I?e aeineiaeaeaiii iieacieeia ?ioiai? ?iaeeie aecia/aee a’yceinoue
neeie, oaeaeeinoue neeiiaeaeieaiiy oa iieacieee ?I-iao???. A’yceinoue
neeie oa oaeaeeinoue neeiiaeaeieaiiy aecia/aeenue ca iaoiaeeeith A. E.
Eaiioue?aa oa TH. A. Iao?iae/a (1976). ?I neeie aecia/aee ia
oiiaa?naeueiiio iiiiii?i AA-74.

Aaeoa?iieiai/ii iaoiaee aeineiaeaeaiiy i?iaiaeeeeny ca iaoiaeeeith A.
Ae. Ia?ooeueeiai oa niiaaao, (1987) oa caiaeii iaoiaee/ieo aeaciaie «I?i
oiioieaoeith iie?iaiieiai/ieo (aaeoa?iieiai/ieo) iaoiaeia
aeineiaeaeaiiy, ui aeei?enoiaothoueny eeiiiei-aeiaaiinoe/ieie
eaai?aoi?iyie eieoaaeueii-i?ioieaeoe/ieo caeeaaeia» (iaeac ?535 IIC N?N?
aiae 22.04.85 ?.). I?iaiaeeeiny oaeiae aecia/aiiy aioaaiiinoe/ii?
aeoeaiinoi aa?ieieia ca iaoiaeeeith A.I. E?aiai/ooeueeiai (1989). Aaoi?
aeneiaeth? ue?o iiaeyeo A. I. E?aiai/ooeueeiio oa ni?a?ia?oieeai
eaoaae?e i?e?ia?ieia?? AeAeIA ca nooo?ao aeiiiiiao a i?iaaaeaii?
aeine?aeaeaiue.

Eaai?aoi?ii iaoiaee aeineiaeaeaiiy aeeth/aee a naaa aecia/aiiy aiinoo
eicioeeio a ?ioiaie ?iaeeii ca iaoiaeeeith E. A. Eaa?aiaiiai? oa A. A.
Aei?ioae/oe (1968), oa aecia/aiiy iiei/ii? eeneioe a ?ioiaie ?iaeeii
iaoiaeii eaeoaoieneaeaciiai naini?a c aeei?enoaiiyi eeioei Aerococcus
viridans (A. I.E?aiai/ooeueeee, 1989).

C iaoith aecia/aiiy aoaeoeaiinoi ae?? ?icieo aioeaaeoa?iaeueieo caniaia
ia ea???niaaiii yeinoi coaiiai iaeueioo, aoee ?ic?iaeaii i aeei?enoaii
iaoiaee i?ioieaeoe/ii? ae?? aioeaaeoa?iaeueieie i?aia?aoaie. Aeioe aoee
?iciiaeieaii ia /ioe?e a?oie.

A ia?oie aeineiaeiie a?oii (n=33) aeioe aeeiioaaee eeoa eiio?ieueiaaio
aia??ii/io /enoeo coaia 2 ?ace ia ??e.

A ae?oaie a?oii niinoa?aaeaiiy (n=34) aeioyi ii?yae c aia??ii/ieie
caoiaeaie i?iaiaeeee aieieaoe?? coaieo ?yaeia 0,02% ?ic/eio
oei?aaeneaeiio aiaetheiiaoo, aeai/i ia ?ie, eo?nii 10 i?ioeaaeo? /a?ac
aeaiue. O?aoy a?oia (n=35) aeioae i?iaiaeeea aia??ii/io /enoeo coaia, a
oaeiae ii i?iaiaeeee aieieaoe?? ?ic/eiii 0,2% oo?aaiio ?ic/eiiiai aeai/i
ia ?ie ca ?ic?iaeaiith iaie iaoiaeeeith, eo?nii 10 i?ioeaaeo? /a?ac
aeaiue. Aeioyi /aoaa?oi? (n=33) a?oie ia?iaii c aia??ii/iei aeiaeyaeii
i?iaiaeeeeny iineiaeiaii aieieaoe?? eiiieaeno oo?aaiio ?ic/eiiiai oa
A-aaeoa?eio ca ?ic?iaeaiith iaie iaoiaeeeith, eo?nii iaeei ?ac a
iia?i//y, eo?nii 10 i?ioeaaeo? /a?ac aeaiue.

Io?eiaii oeeo?iai aeaii aoee noaoenoe/ii ii?aoeueiaaii c aeei?enoaiiyi
iaoiaeee oa ea?iaieoeoaa ii noaoenoeoei (Ae. Naiaoe??a, 1968; I. O.
?ieeonueeee, I. ?. ?itheia, 1986), c ?ic?aooieaie e?eoa?ith
Nouethaeaioa.

Aenia?eiaioaeueiee oa eeiii/iee iaoa?iae aoa ii?aoeueiaaiee ia IAAI IAI
?N/AO c aeei?enoaiiyi noaiaea?oieo i?ia?ai.

?ACOEUeOAOE AeINEIAeAEAIIss

O aiaeiiaiaeiinoi c cacia/aiith iaoith oa caaea/aie aeineiaeaeaiiy aoee
ianoaaeai? ae?oe a?eii 5-10 ?ie?a oa aecia/ai? iniiai? iieacieee
caoai?thaaiino? ia ea???n ca aeaieie iioe?aiino? oa ?ioaineaiino?.
Anoaiiaeaii, ui a oiiaao i?iieneiaiai iaaaioaaeaiiy, yeei ?
I?eaei?i?ia’y, iioe?ai?noue ea???no o ae?oae 5-7 ?ie?a neeaea 92,8%, a o
ae?oae 8-10 ?ie?a — 90,3%. ?ioaineai?noue ea???no ca aeaieie EIA+ei
neeaea 5.62+/-0.40 o ae?oae 5-7 ?ie?a, oa 6.33+/-0.50 o ae?oae a?eii
8-10 ?ie?a.

I?iaaaeaii eeiiiei-aenia?eiaioaeueia aea/aiiy caniao iie?ii?aaiiciaie
ii?iaeieie ?ioa aeineiaeiiai eiioeiaaioo aeioae. I?e oeueiio aea/aii
?ieue eeneioiooai?thth/eo aaeoa?ie o i?ioeanao aeaiiia?aeicaoe?? aiaei
coaia, a oaeiae aei?iaoaai? aiaeiii (oei?aaeneaeii) oa iaeiaea/aii
(oo?aaii oa eiiieaen A-aaeoa?eio i oo?aaiio) i?aia?aoe a i?eaii/aiii
eeneioiooai?thth/eo aaeoa?ie.

sse aiaeiii, oeyoii oa?iaioaoe?? aioo?ioiueieeioeiiiai oa?aeoa?o ?yae
aaeoa?ie (iniaeeai ?iaeo Streptococcus) coaiiai iaeueioo ia?aoai?th?
caeeoee aoaeaaiaeia a eiioeaai i?iaeoeoe — i?aaii/ii eeneioe (?. A.
Ai?ianueeee, ?. ?. Ieaeiee, 1991). I?ioean oa?iaioaoe?? ?aoiiiaaieo
aoaeaaiaeia a cia/iie ii?i aeoeao?oueny iiiaie aaaeeeo iaoaeia, a naia
caeicii, oeeieii, eiaaeueoii, ui ciaoiaeyoueny a iaaeii?iie eieueeinoi a
i?aaiicii aeioae, yei iaoeathoue a oiiaao iioaineaieo i?iieneiaeo
?ic?iaie (I. A. Ei?aiaiia, 1993). Oiio iiaeia i/ieoaaoe ia o?eueee
cia/ieo ciii aiioeaiico ii?iaeieie ?ioa o aeioae aeieiai/ii
iani?eyoeeaiai i?iieneiaiai ?aaiiio, aea aeniea ai?iaiaeiinoue caeaiai
iaaeoiaeaeaiiy aei i?aaiicio ?icieo aaaeeeo iaoaeia, aea e iaea?eueo
oaeaeeiai cieaeaiiy eiioeaio?aoe?? eeneio i?ae oa?ii coaiiai iaeueioo
aei e?eoe/iiai cia/aiiy pH 4.5-5.5, ui ??cei i?enei?th?
aeai?ia?ae?caoe?th aiae?. A cia/iie ii?i oei i?eiouaiiy aoee
iiaeoaa?aeaeaii iaoeie eeiiiei-aenia?eiaioaeueieie aeineiaeaeaiiyie
oa?aeoa?o aaeoa?iaeueiiai caniao a ii?iaeieii ?ioa aeioae a?oi
niinoa?aaeaiiy. Aeaieie niaoeiaeueieo aaeoa?iieiai/ieo aeineiaeaeaiue
anoaiiaeaii, ui coaiee iaeio o aeioae 5-10 ?i/iiai aieo iioaineaii
caniyiee oaeeie aaeoa?iyie ye Streptococcus, Staphylococcus,
Diphteroidum, Lactobacterium, Aerococcus viridans. I?e oeueiio /anoioa
aeniaaiiy aaeoa?ie ?iaeo no?aioieiea, ye iniiaiiai eeneioii?iaeooeaioa
ia iiaa?oii coaa, neeaaea? 100%. Iaeiae, neiae cacia/eoe, ui o aeioae c
aenieith iioaineai?noth ea???no e?euee?noue Streptococcus a aaniethoieo
cia/aiiyo aoea aeinoia??ii aeuith, i?ae o i?aeoe/ii caei?iaeo ae?oae
(?<0.05). Ii?yae c oeei aecia/aii aieueo iecueei aaniethoii cia/aiiy eiioeaio?aoe?? Aerococcus viridans o aeioae aeineiaeieo a?oi. O aeioae c aenieith ?ioaineaiinoth ea???no ai?iaiaeii iiaeaeuaiee aiino i?yieo i?iaeooeaioia i?aaii/ieo eeneio a coaiiio iaeueioi, eio?eie ? St.mutans i salivarius (oaae. 1). Oaaeeoey 1 Oa?aeoa?enoeea aeae?a Streptococcus coaiiai iaeueioo o ae?oae c aenieith ?ioaineai?noth ea???no a lg/ie (Mm) ? i/iAeaee StreptococcusEiio?ieueia a?oia;n=33Aeine?aeia a?oia; n=102?1.sanguis3,70,33,80,2>0,052salivarius3,10,13,60,1<0,053.mutans2,90 ,13,40,1<0,05 Iaaaoeaiei yaeuai neiae aaaaeaoe aeyaeaia iaie ai?iaiaeia cieaeaiiy ??aiy iaeiiai c iiaeoeaaoi?ia i?aaii/ieo eeneio - Aerococcus viridans o ae?oae c aenieei nooiaiai aeoeaiino? ea???no coa?a a ii??aiyii? c eiio?ieueiith a?oiith. Oaea cieaeaiiy a cinoaaeaiii c iniaaie aeieiai/ii /enoiai ?aaiiio neeaei 50%, ui ?icoe?iaii, ye iaaia ineaaeaiiy caoenieo iaoai?ci?a ii?iaeieie ?ioa. Ana oea ? naiae/aiiyi nooo?ai? iai?oae ea???niaaiii? neooaoe?? a ii?iaeieii ?ioa, yea caeaaeeoue ye aiae nooiaiy aaeoa??aeueiiai can?ao, oae ? a?ae aeniei? cae?aiino? ?yaeo aaeoa??e aei eeneioiooai?aiiy oa cieaeaiiy iioeie aaeoa?iyie caeiaiinoi aei iaeo?aeicaoe?? eeneio. Aecia/aii yaeua a coaiiio iaeueioi iniaeeai aaaeeeai a ia?iiae aeic?iaaiiy aiaei coaia iiney io i?i?icoaaiiy. Aeey iaa?oiooaaiiy aeei?enoaiiy i?iaeoeoo Aerococcus viridans - A-aaeoa?eio aeey i?io?eaeoeee ea???no coa?a i?iaaaeaii iiaeaeueii aeineiaee aea/aiiy caeiaiinoae aa?ieieia ieeneyoe iiei/io eeneioo (oaae. 2). Anoaiiaeaii, ui ani ooaie Streptococcus coaiiai iaeueioo (mutans, sanguis, salivarius) iaeiaeiai /ooeeai aei ae?? aaeoa?ie - ia?aeen-i?iaeooeaioia, oae ye i?iaeoeoeiy iiei/ii? eeneioe oniia ooaiaie no?aioieieia cieaeo?oueny a 20-30 ?acia. Oaaeeoey 2 Iieacieee ieeneaiiy iiei/ii? eeneioe (IE) eeneioii?iaeoeoth/eie ee?oeiaie Aerococcus viridans a ie?ae. (Mm) ?Ooaie Eiioeaio?aoe?y IECia/aiiyi/ino?aioieieaAei ae??I?ney ae???1.S. salivarius0,20,010,010,0001<0,052.S. sanguis0,30,030,010,0002<0,053.S. mutans0,50,10,20,002>0,05

Oea iiaeoaa?aeaeo? aenieo caeiaiinoue A. viridans, ye
ia?aeen-i?iaeooeaioa ii?iaeieie ?ioa, a iaeo?aeicaoe?? iiei/ii? eeneioe,
a cia/eoue ? a cieaeaii? cae?aiino? coaii? aeyoee aei aeaiiia?aeicaoe??
aiaei. Oaeei /eiii, iaeo?aeicaoeiy iaeiiai c iaoaaieioia ?aoiiiaaieo
aoaeaaiaeia ia? aeey aiiainoaco ii?iaeieie ?ioa aiaeaa?oi ei?eaoth/a
cia/aiiy, oae ye ao?o/a?oueny a oiiei iaoaiicie iaoiaaiaco ea???no
coaia.

Caiaeii c caaea/aie iaie aea/aia caeaoiinoue ?icieo aioeaaeoa?iaeueieo
caniaia aieeaaoe ia ?ino ooaiia no?aioieieia, aeaeieaieo c ii?iaeieie
?ioa (oaae. 3).

Anoaiiaeaii, ui i?eaii/aiiy ?inoo anio ooaiia no?aioieiea iaeaieueo
ae?acia i?e aeei?enoaiii eiiieaeno ?ic/eio oo?aaiia oa A-aaeoa?eio. ?
iiaenoaae aeoiaoe, ui oo?aaii oa A-aaeoa?ei aaeaei iiaeneeththoue aeith
iaeia iaeiiai.

Aiaeiiaiaeii iaoei niinoa?aaeaiiyi a eiioei i’yoe?i/iiai ia?iiaeo
eieueeinoue iie?ii?aai?ci?a onio ooaiia no?aioieiea iaeaieueo ae?acii
ciaioeeanue iiae ae??th oeueiai eiiieaeno a ii?iaiyiii c iioeie
i?aia?aoaie.

Iiaeoaa?aeaeaiiyi iiceoeaiiai aieeao cai?iiiiiaaiiai iaie
aioeaaeoa?iaeueiiai eiiieaeno ia oi?ioaaiiy aiae? a ia??iae aeic??aaiiy
o niieo/aii? c eiio?ieueiaaiith aia??iith yaey?oueny aeeiai?/ia
ciiia

Oaaeeoey 3

Na?aaei? ?ici??e cii aaeueioaaiiy ?inoo Streptococcus a?ey oo?eoiaiai

iaeueioo ??cieo aioeaaeoa??aeueieo cania?a a ii (Im)

I?e?ii?aai?cieStreptococcusI?aia?aoemutanssalivariussanguis0,02% ?ic/ei
oei?aaeneae?io

a?aetheiiaoo6,80,109,61,55,20,20,2% ?ic/ei oo?aa?io7,20,09

p<0,0510,22,8 p>0,056,00,1

p<0,05Eiiieaen 0,2% ?ic/eio oo?aa?io oa A-aaeoa?eio12,90,7 p<0,0511,41,7 p>0,0512,20,6

p<0,05 I?ei?oea: Aeinoia??i?noue aecia/aia a ii??aiyii? c 0,02% ?ic/eiii oei?aaeneae?io. iieacieeia caoai?thaaiinoi coaia ia ea???n o aeioae a?eii 5-10 ?ie?a. Aeeiai?ea i?inoaaeaia ia i?ioyc? i'yoe ?ie?a ia /ioe?ueio aeine?aeieo a?oiao (oaae. 4). I?e oeueiio ia?oa a?oia aeioae i?iaiaeeea eeoa eiio?ieueiaaio aia??io ii?iaeieie ?ioa, ae?oaa - niieo/aea eiio?ieueiaaio /enoeo c aieieaoe??th ia coaii ?yaee ?ic/eio oei?aaeneaeiio, a o?aoie i?iaiaeeee aieieaoe?? ?ic/eiii oo?aaiio, a a /aoaa?oie aeei?enoaee aieieaoe?? ia coaii ?yaee eiiieaeno ?ic/eiia oo?aaiio i A-aaeoa?eio ia oiii eiio?ieueiaaii? /enoee coaia. I?iaaaeaii niinoa?aaeaiiy o aeioae ia?oi? a?oie c on??th aiaeaa?oinoth naiae/eee i?i aeayeo ?acoeueoaoeaiinoue aia??ii/ieo caoiaeia a ii?iaeieii ?ioa aeioae, ye neeaaeiai? ia?aeiii? noiiaoieiai/ii? i?ioieaeoeee. Io?eiaii aeaii aeacothoue ia iaai? ci?ie iieaciee?a caoai?thaaiino? ia ea???n ye o ae?oae iieiaeoiai aeioe?eueiiai a?eo, oae ? o oeiey??a. I?e??no ?ioaineaiino? ea???no o ae?oae 5-7 ?ie?a neeaa ca aeaieie EIA 0.39 (?>0.05), a o ae?oae 8-10 ?ie?a — 0.59(?>0.05). Ioeiithth/e a
oeieiio iiceoeaia cia/aiiy aia??ii/ieo caoiaeia a ii?iaeieii ?ioa
iaiaoiaeii caiaeeoenue c oei, ui aiie iiaeooue neoaeeoe oaa?aeei a?oioii
aeey aeei?enoaiiy aieueo iioaineaieo caoiaeia ia?aeiii? noiiaoieiai/ii?
i?ioieaeoeee.

Iiaeoaa?aeaeaiiyi oaei? aeoiee noaee ?acoeueoaoe, io?eiaii ia aeioyo
ae?oai? aeineiaeii? a?oie, a yeie e?ii eiio?ieueiaaii? /enoee coaia
aeei?enoaia aieieaoeiy ia coaii ?yaee ?ic/eio oei?aaeneaeiio. Ia iniiai
aiaeico aeeiaiiee iioaineaiinoi oa i?e?inoo iioaineaiinoi ea???no coaia
aeiaaaeaia aieueo aeniea i?ioieaeoe/ia aoaeoeaiinoue ?ic/eio
oei?aaeneaeiio. A oeieiio neiae aeciaoe, ui aeei?enoaiiy noaiaea?oiiai
aioeaaeoa?iaeueiiai caniao a niieo/aiii c eiio?ieueiaaiith /enoeith
coaia ia i?ioyci o?eaaeiai ia?iiaeo caeaoia iiceoeaii ciiithaaoe oeieo
ieceo oiia a ii?iaeieii ?ioa, ui caaacia/othoue iioeiaeueio
iiia?aeicaoeith oaa?aeeo oeaiei. Oaea yaeua iiceoeaiei /eiii
aiaeoai?eeinue ia iieacieeao i?e?inoo, iioe?aiinoi i iioaineaiinoi
ea???no coaia aieueo ae?acii, iiae o aeioae ia?oi? aeineiaeii? a?oie. O
niinoa??aa?ieo ae?oae aeioe?eueiiai a?eo i?e??no ?ioaineaiino? ea???no
neeaa 0.32 (?>0.05), a o ae?oae oe?eueiiai a?eo 0.49 (?>0.05).

?acii c oei io?eiaii ?acoeueoaoe i?ioieaeoe/iiai aoaeoo a oeieiio ia
aeoiaeeee ca iaaei, aiaeiii a iaoeiaie eioa?aoo?i.

Inue /iio aeieeea caoeieaaeaiinoue aea/eoe aoaeoeaiinoue aeei?enoaiiy
?ic/eio oo?aaiio a i?ioeea?iiciie i?ioieaeoeoei. sse i neiae aoei
i/ieoaaoe, aeeiaiiea caoai?thaaiinoi coaia ia ea???n iiney i’yoe?i/iiai
aieeao aia??ie ii?iaeieie ?ioa oa aieieaoeie ?ic/eiii oo?aaiio noaea
aieueo ae?aciith, iiae a ia?oie oa ae?oaie aeineiaeieo a?oiao. Aeioe
o?aouei? a?oie iaee i?e?ino iioaineaiinoi o aeioe?eueiyo — 0.31
(?>0.05), a o ae?oae 8-10 ?ie?a — 0.39 (?>0.05).

Aea/aiiy oa?aeoa?o aeeiaiiee caoai?thaaiiy ia ea???n coaia o aeioae
/aoaa?oi? aeineiaeii? a?oie, a yeie aeei?enoaee aieieaoe?? ia coaii
?yaee eiiieaeno ?ic/eiia oo?aaiio i A — aaeoa?iio, iieacaee iaeaieueo
aenieo eiioeaao ?acoeueoaoeaiinoue. Iiney i’yoe?i/iiai oa?iiio
niinoa?aaeaiue i?e?ino iioaineaiinoi ea???no coaia neeaaeaa o ae?oae 5-7
?ie?a — 0.27 (?>0.05), a o ae?oae 8-10 ?ie?a — 0.24 (?>0.05).

Aioeaaeoa??aeueiee aieea ia ea???niaaii? aeanoeaino? coaiiai iaeueioo
i?e ye?niiio i?iaaaeaii? caoiae?a caeaoiee acaaae? iie?ioeoe aiiainoac
?ioiai? ii?iaeieie. Oea aoei i?aeoaa?aeaeaii iaoeie niinoa?aaeaiiyie.
I?e aeei?enoaii? oei?aaeneae?io, oo?aa?io, oa iine?aeiaiiai eiiieaeno
oo?aa?io oa A-aaeoa?eio o ae?oae an?o /ioe?ueio a?oi aoea i?inoaaeaia
oaiaeaioe?y aei iie?auaiiy iieaciee?a aeanoeainoae ?ioiai? ??aeeie oa
ianiaoeeo?/ii? ?ac?noaioiino? a ii?iaeiei? ?ioa. Nooo?ai iie?ioeeenue
iieacieee oaeaeeino? neeiiaeae?eaiiy, pH ?ioiai? ??aeeie oa ??
a’yceino?.

Oaaeeoey 4

Aeeiai?ea iieaciee?a caoai?thaaiino? ia ea???n coa?a o ae?oae i?ae
aieeaii aioeaaeoa??aeueii? i?io?eaeoeee (Im)

A?oiaA?e ae?oaeianoaaeaieo5-7 ?ie?a8-10
?ie?ain?a?ioaineai?noue?ioaineai?noueeiEIAeiEIAIa?oa aeine?aeia a?oia;
n=33wmetafile8? ??8???????????
???????????yyy????.????1?????? ???????  
???&??yyyy?????Ayyy¶yyya??Oe?? ???&? ?MathType????
???u?????????»????-?????ue@????ueC???u?th??????iieacieea0
,63

?1<0,050,39 ?1<0,05-0,59 ?1<0,05Ae?oaa aeine?aeia a?oia; n=34wmetafile8? ??8??????????? ???????????yyy????.????1?????? ??????? ?@???&??yyyy?????Ayyy?yyy?????? ???&? ?MathType??A? ???u?????????"????-?????ue@????uei???u?th??????iieacieea0 ,60 ?1>0,05, P2>0,050,32

?1>0,05, P2>0,05-0,49

?1<0,05, P2>0,05O?aoy aeine?aeia a?oia; n=35wmetafile8?
??8??????????? ???????????yyy????.????1??????
??????? ?`???&??yyyy?????Ayyy?yyy ????? ???&?
?MathType??A?
???u?????????»????-?????ue@????ue???u?th???????1<0,05, P2>0,050,31

?1>0,05, P2>0,05-0,39

?1<0,05, P2>0,05*aoaa?oa aeine?aeia a?oia; n=33wmetafile8?
??8??????????? ???????????yyy????.????1??????
??????? ?@???&??yyyy?????Ayyy?yyy?????? ???&?
?MathType??A?
???u?????????»????-?????ue@????uee???u?th??????iieacieea0
,12

?1<0,05, P2>0,050,27

?1<0,05, P2>0,05-0,24

?1<0,05, P2>0,05

I?ei?oee: 1. /enaeueiee — iieaciee ?ioaineaiino? aei i?iaaaeaiiy
caoiae?a,

ciaiaiiee — iieaciee ?ioaineaiino? i?ney i’yoe??/iiai

niinoa?aaeaiiy;

2. ?1 — aecia/aii a aeeiaieoe? o a?oiao niinoa?aaeaiiy,

?2 — aecia/aii o ii??aiyii? c aeaieie ia?oi?
aeine?aeii? a?oie.

Ca aeaieie aeine?aeaeaiue aeei?enoaiiy iine?aeiaiiai eiiieaeno oo?aa?io
oa A-aaeoa?eio ni?eyei iie?auaiith nooiaiy i?ia?ae?caoe?? oaa?aeeo
oeaiei coa?a, iniaeeai o ae?oae oe?eueiiai a?eo.

Aac ia?aaieueoaiiy iiaeia neacaoe, ui iaaee/ia aoaeoeaiinoue eiiieaeno
oo?aaiio oa A-aaeoa?eio ia oiii nenoaiaoe/ii? /enoee coaia aieiae??
iaeaieueo aenieith ia?aaaaith a ii?iaiyiii c iioeie caniaaie, iniaeeai o
aiaeiiaiaeaeueiee ia?iiae aeic?iaaiiy aiaei coaia.

Neiae cacia/eoe, ui ca aanue ia?iiae i’yoe?i/iiai niinoa?aaeaiiy aaeeei?
a?oie aeioae ia aoei iaaaoeaiiai aieeao ye a oeieiio ia i?aaiici
aeeoeie, oae i iinoeaai a ii?iaeieii ?ioa i?e aeei?enoaiii ?ic/eiia
oo?aaiio i A-aaeoa?eio.

AENIIAEE

1. A oiiaao aeieiai/ii caa?oaeiaiiai i?iieneiaiai I?eaeiii?ia’y c
ia?aaaaeii iaoaeo?aieiei ae?iaieoeoaii, niinoa?iaa?oueny c?inoaiiy
iieacieeia iioe?aiinoi (aei 92,8%) oa iioaineaiinoi (aei 6,33+/-0,50 ca
aeaieie EIA+ei) ea???no o aeioae 5-10 ?i/iiai aieo.

2. Iniaeeainoth caniao ea???niaaiiith oei?ith coaiiai iaeueioo o aeioae
5-10 ?i/iiai aieo, yei iaoeathoue a oiiaao i?iieneiaiai I?eaeiii?ia’y, ?
cieaeaiiy i?aaenoaaieeia ?iaeo Aerococcus oa ia?aaaaeaiiy
eeneioiooai?thth/eo iie?ii?aaiiciia ?iaeo Streptococcus (aeaeia mutans
oa salivarius).

3. Anoaiiaeaia aeniea aioeaaeoa?iaeueia aoaeoeaiinoue ae?? ia iie?ioei?o
coaiiai iaeueioo (iniaeeai eeneioii?iaeoeoth/o) 5-10 ?i/ieo aeioae i?e
aeei?enoaiii ?ic/eiia oo?aaiio oa A-aaeoa?eio, i?e oeueiio eiiieaenia
aeei?enoaiiy oeeo i?aia?aoia ia? iaeaieueo ae?aciee aoaeo, yeee
ia?aaeuo? aeith oei?aaeneaeiio o 2 ?ace.

4. Aeiaaaeaia aeniea i?ioeea?iicia aoaeoeaiinoue eiiieaeniiai
aeei?enoaiiy ?ic/eio oo?aaiio oa A-aaeoa?eio a ee?i?oe?, ui
aiaeia?aceeinue a iecueeeo oeeo?iaeo iieacieeao i?e?inoo iioaineaiinoi
ea???no coaia o aeioae, a oaeiae a?aenooi?noue iaaaoeaiiai aieeao
i?noeaaiai oa caaaeueiiai oa?aeoa?o i?ae /an i?iaaaeaiiy i?io?eaeoe/ieo
caoiae?a.

5. ?ic?iaeaiee oa ai?iaaaeaeaiee a i?aeoeeo cania aeei?enoaiiy eiiieaeno
?ic/eiia oo?aaiio oa A-aaeoa?eio ni?yiiaaiee ia cieaeaiiy aeoeaiinoi
ea???niaaiii? iie?ioei?e (?iaeo Streptococcus), oa iiaeaeuaiiy
aeoeaiinoi ia?aeen-i?iaeooeaioia (?iaeo Aerococcus), ui a oe?eiio
iioeieco? oiiae ?aiiia?aeicaoe?? aiaei coaia, a ye ianeiaeie, i
iiia?aaeaeo? aeieeiaiiy ea???no.

I?AEOE*II ?AEIIAIAeAOeI?

A aeieiai/ii neeaaeiiio i?iieneiaiio I?eaeiii?ianueeiio ?aaiiii iaoeaiiy
aeioae 5-10 ?i/iiai aieo aaaea aei ciiie aiioeaiico a ii?iaeieii ?ioa o
aie cieaeaiiy ?iaiy iie?ii?aaiiciia ?iaeo Aerococcus, ye iaeiiai c
iinoeaaeo oaeoi?ia ianiaoeeoi/iiai caoenoo, ui ni?ey? caaino?aiith
ea???niaaiii? neooaoe?? oa iio?aao? oeieani?yiiaaieo ao?o/aiue.

Ae?oyi c aenieith ?ioaineai?noth ea???no oa iacaaeia?eueiei a?a??i?/iei
noaiii ii?iaeieie ?ioa iaiao?aeii i?ecia/aoe iine?aeiaiee
aioeaaeoa??aeueiee eiiieaen aie?eaoe?e oo?aa?io oa A-aaeoa?eio aea?/? ia
??e, iniaeeai a ia??iae aeic??aaiiy aiae? iino?eieo coa?a.

Aeei?enoaiiy neeaaeiiai eiiieaeno oo?aaiio oa A-aaeoa?eio aeicaiey? o
iiaenoieo cia/ii cieceoe i?e?ino iioaineaiinoi ea???no coaia o 5-10
?i/ieo aeioae i?e o?ueio-i’yoe??/iiio i?iaaaeaii? i?io?eaeoe/ieo
caoiae?a.

NIENIE IIOAEIEIAAIEO IAOEIAEO I?AOeUe

1. Aioeaaeoa?iaeueia i?ioieaeoeea ea???no coaia o aeioae //Aanoiee
i?iaeai aeieiaee e iaaeeoeeiu. — Iieoaaa-Oa?ueeia, 1998. — ?2. — N.
46-53.

2. Iniaeeainoi caniao aaeoa?iaeueiith oei?ith coaiiai iaeueioo o aeioae
5-10 ?i/iiai aieo //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. —
Iieoaaa-Oa?ueeia, 1998. — ?5. — N. 96-102.

3. Cia/aiiy ia?aeenae?iaeyth/eo aaeoa?ie a ii?iaeieii ?ioa o aeioae
//Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. — Iieoaaa-Oa?ueeia, 1998. — ?5.
— N. 103-110.

4. Ninoiyiea iiei/iuo coaia o oanoeeaoieo aeaoae a. Aeiai?iiao?ianea
//Aiiio. i?ia. iao/. i?ae. eiio. «Nieae e ae?oaea eioaeoeee,
ia?aaeathueany iieiaui iooai». — Aeiai?iiao?iane, 1991. — N. 104-104.

5. Aicaeaenoaea i?aia?aoia ieo?ioo?aiiaiai ?yaea ia iee?ioei?o coaiiai
iaeaoa o aeaoae aeioeieueiiai aic?anoa /Aeooaeueii ieoaiiy noiiaoieia??
aeeoy/iai aieo i i?oiaeiio?? // ?ani. iaoe. eiio. — Iieoaaa, 1993. — N.
26-26.

6. Caeaaeiinoue iioaineaiinoi ea???no aiae ?iaiy oice/iiai ?icaeoeo
aeioae aeioeieueiiai oa oeieueiiai aieo//Aeooaeueii i?iaeaie no/aniii
noiiaoieia?? oa caaaeueii? iaaeeoeeie. — Aeiii?iiao?ianuee, 1993. — N.
88-90.

AIIOAOeIss

Eo/a?aiei I. I. «Aieea aioeaaeoa?iaeueieo caniaia ia ea???niaaiii
aeanoeainoi coaiiai iaeueioo». ?oeiien.

Aeena?oaoeiy ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoeiaeuei?noth 14.01.22 — Noiiaoieiaiy. Oe?aaeinueea iaaee/ia
noiiaoieia?/ia aeaaeaiiy IIC Oe?aaeie, i. Iieoaaa, 1998.

Aea/aia ?ieue aioeaaeoa?iaeueieo i?aia?aoia oei?aaeneaeiio, oo?aaiio i
A-aaeoa?eio a i?ioieaeoe/ieo caoiaeao ea???no coaia o aeioae 5-10
?i/iiai aieo a cinoaaeaiii. A aiaeic acyoi ?acoeueoaoe i’yoe?i/iiai
niinoa?aaeaiiy iaae 1205 aeioueie. Anoaiiaeaii, ui ani aeineiaeii
aioeaaeoa?iaeueii caniae i?eaii/othoue ?ino Streptococcus, i?e/iio
aeineiaeiee eiiieaen canoinoaaiiy A-aaeoa?eio oa oo?aaiio ia? aieueo
aeniei oa?aeoa?enoeee oaeiai aieeao. Aei?iaoaaii a eeiiioei caniae
aeicaieeee inoioii cieceoe caoai?thaaiinoue ia ea???n coaia, i?e/iio
eiiieaen oo?aaiio i A-aaeoa?eio ciecea i?e?ino iioaineaiinoi ea???no
oaea?/? a ii??aiyii? c aeei?enoaiiyi oei?aaeneae?io.

Eeth/iai neiaa: ea???n coaia, aioeaaeoa?iaeueii caniae, coaiee iaeio,
ea???niaaiii aeanoeainoi, i?ioieaeoeea.

AIIIOAOeEss

Eo/a?aiei A.I. «Aeeyiea aioeaaeoa?eaeueiuo n?aaenoa ia ea?eaniaaiiua
naienoaa coaiiai iaeaoa». ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.22 — Noiiaoieiaey. Oe?aeineay iaaeeoeeineay
noiiaoieiae/aneay aeaaeaiey IC Oe?aeiu, a. Iieoaaa, 1998.

Eco/aia ?ieue aioeaaeoa?eaeueiuo i?aia?aoia oei?aaeneaeeia, oo?aaeia e
A-aaeoa?eia a i?ioeeaeoe/aneeo ia?ii?eyoeyo ea?eana coaia o aeaoae 5-10
eaoiaai aic?anoa a niiinoaaeaiee. A aiaeec acyou ?acoeueoaou iyoeeaoiaai
iaaethaeaiey iaae 1205 aeaoueie. Onoaiiaeaii, /oi ana enneaaeoaiua
aioeaaeoa?eaeueiua n?aaenoaa iiaeaaeytho ?ino Streptococcus, i?e/ai
eniuouaaaiue eiiieaen i?eiaiaiey A-aaeoa?eia e oo?aaeia eiaao aieaa
aunieea oa?aeoa?enoeee oaeiai iiaeaaeaiey. Eniuoaiiua a eeeieea
n?aaenoaa iicaieeee nouanoaaiii nieceoue caaieaaaaiinoue ea?eanii coaia,
i?e/ai eiiieaen oo?aaeia e A-aaeoa?eia niecee i?e?ino eioaineaiinoe
ea?eana aaeaia ii n?aaiaieth n eniieueciaaieai oei?aaeneaeeia.

Eeth/aaua neiaa: ea?ean coaia,aioeaaeoa?eaeueiua n?aaenoaa, coaiie
iaeao, ea?eaniaaiiua naienoaa, i?ioeeaeoeea.

ANNOTATION

Kucherenko A. N. Influence of antibacterial means on the cariois
characteristics of dental plaque. Manuscript.

Dissertation for the scientific degree of candidate of medical sciences
on the Dentistry (14.01.22) Ukrainian medical Stomatological academy,
the MPH, Poltava, 1998.

The possibilities of preparations type chlorhexidin,furagin and complex
of furagin and A-bacterin in prophylaxis of children’s caries have becn
studied.

The paper deals with the analys of results of 5 year period of examinihg
1205 children at the age of 5-10 years old.

It is stated that all the examining antibacterial preparations supress
growth of Streptococcus; and as for complex of furagin and A-bacterin,
it has higher results of bacteria’s suppression.

The preparations which are examined in clinic give the opportunity to
reduce disease of caries and we must take into consideration that
complex of furagin and A-bacterin have reduced growth caries doubly
(twice) in comparison with using chlorgexidin.

Key words: antibacterial means, prophylaxis, dental plaque, cariois
characteristics.

I?aei aei ae?oeo 25.08.98?.

Oi?iao 6084 1/16

Oiia. ae?. a?e. 1,0 Iae. aeae.a?e. 1,0

Oe?aae 100 i?ei. Caiia. 126.

Iaae?oeiaaii IE(ae?oea? AeAeIA)

i. Aei?i?iiao, ie. AEiaoiaaa,4

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