I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

IAeANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

OAeE 617.215.34: 547

NEIIAAOeUe Iaoae?y Eaii?ae?aia

AIEEA AIAEIA?A IAE?IIAIOEAe?A IA NOAI

AAeAIOAOe?EIEO IAOAI?CI?A I?E IA?EOII?O?

(aenia?eiaioaeueia aeine?aeaeaiiy)

14.03.04 — iaoieia?/ia o?c?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Iaeana — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Iaeanueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
I?ienoa?noaa ioi?iie caei?ia’y Oe?a?ie

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

Aeaieaeia Aieiaeeie? Ieoaeeiae/, Iaeanueeee aea?aeaaiee iaaee/iee
oi?aa?neoao IIC Oe?a?ie, i?ioani? eaoaae?e caaaeueii? o??o?a??

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? Aiaeeaanueeee
Eaii?ae Naiaiiae/, Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC
Oe?a?ie, i?ioani? eaoaae?e ii?iaeueii? o?c?ieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

?icaiia Anaaieiae Aiaoie?eiae/, Iaeanueeee a?ae?iiaoai?ieia?/iee
?inoeooo II Oe?a?ie, i?ioani? eaoaae?e caaaeueii? aeieia??

I?ia?aeia onoaiiaa: ?inoeooo aa?iioieia?? AII Oe?a?ie, eaai?aoi??y
iaoio?c?ieia?? ? ?ioiieia??, i?noi Ee?a

Caoeno a?aeaoaeaoueny «_____» _____________ 1999 ?. i _____ aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.600.01 Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (270100, i. Iaeana, i?ia.
Aae?oianueeee, 2).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (270100, i. Iaeana, i?ia.
Aae?oianueeee, 3).

Aaoi?aoa?ao ?ic?neaiee «_____» _______________ 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee, aeioeaio

?iaeeianueea I.I

Aeooaeuei?noue oaie. Iacaaaeath/e ia ?ic?iaeaio aaaaoueia iieie?iiyie
o??o?a?a /?oeo aeieo?eio e?eoaaiiy, no/ania aianoac?ieia?/ia oa
?aai?iaoe?eia caaacia/aiiy, iayai?noue oe?ieiai a?naiaeo
aioeaaeoa?eaeueieo cania?a, eaoaeuei?noue /a?ac ?iciianthaeaeai? oi?ie
ia?eoii?oo inoaii?ie ?ieaie ia cieceeany, noaiiaey/e, ca aeaieie
??ciiiai?oieo aeine?aeiee?a, a?ae 20 aei 70% (A.E. No?o/eia, 1981;
A.A.Oaeeiia, 1991; A.N.Naaaeueaa, 1996).

Iaao?oi? ?acoeueoaoe e?eoaaiiy oai?eo c ia?eoii?oii aeeeeeai?,
ia?aaeon?i, /eneaieie iaoiaaiaoe/ieie ii?ooaiiyie, ui aeieeathoue i?ae
/an oe??? oyaeei? iaoieia??. Iie?auaiiy ?acoeueoao?a e?eoaaiiy oai?eo c
ia?eoii?oii iia’ycaia c iiaeeea?noth aieeao ia caaaeuei? eaiee
iaoiaaiaco caoai?thaaiiy.

Aoaeo/e ??ciiaeaeii o??o?a?/iiai no?ano, aino?ee ia?eoii?o
noi?iaiaeaeo?oueny aeeaieeie c?ooaiiyie aaeaioaoe?eieo iaoai?ci?a,
i?iyaii /iai ? ii?ooaiiy iae?iaiaeie?eiii? ?aaoeyoe?? (I.E.Ae?iaeia,
1996), o nenoai? IIE (A.I.Oi?aeineee, 1994).

Iiyaa iiaeo e?ea?nueeeo i?aia?ao?a — aiaeia?a iae?iiaioeae?a —
aeicaiey? ?ic?iaeyoe i?eioeeie oa?iaeieia?/ii? ei?aeoe?? c?ooaiue
aaeaioaoe?eieo iaoai?ci?a, a oiio /ene?, e ca oaei? no?an-aaia?oth/i?
iaoieia??, yeith ? ?iceeoee ai?eiee ia?eoii?o.

Ia c’yniaaieie ca?ac ? ci?ie ai?iiiaeueii? nae?aoe?? ia ??cieo ??aiyo
aoii?aeueii? ?aaoeyoe?? i?ae /an aino?iai aenia?eiaioaeueiiai ia?eoii?oo
(AAI). I?iaeaia iaoiaaiaoe/iiai iaa?oiooaaiiy canoinoaaiiy aiaeia?a
iae?iiaioeae?a ca oiia AAI ia ia? aeinoaoiueiai a?aeia?aaeaiiy o
iaoeia?e e?oa?aoo??. Cacia/aia e noaiiaeei iai?yiie iaoiai
aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iao?
aeine?aeaeaiiy i?iaeiaaeothoue oa ?icaeaathoue iaoeiaee iai?yiie, yeee
?ic?iaey? eaoaae?a caaaeueii? o??o?a?? Iaeanueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo, c aeine?aeaeaiiy ooieoe?iiaeueii? aeoeaiino?
?aaoeyoi?ieo ai?iiiaeueieo nenoai oa ?o i?e?iaeieo iaoaaie?o?a,
oi?iaaaeaeaiiy ?o neioaoe/ieo aiaeia?a ye e?ea?nueeeo cania?a (? aea?ae.
?a?no?aoe?? 0195U022687).

Iaoith ?iaioe aoei anoaiiaeaiiy caeiiii??iinoae iaoiaaiaoe/ieo ii?ooaiue
a nenoai? iae?iaoii?aeueii? ?aaoeyoe?? i?ae /an AAI oa iaoiaaiaoe/ia
iaa?oiooaaiiy canoinoaaiiy aiaeia?a iae?iiaioeae?a o eiiieaeniiio
e?eoaaii? AAI.

Iniiai? caaaeaiiy aeine?aeaeaiiy aoee oaeeie:

Ia iiaeae? AAI a aeeiai?oe? caoai?thaaiiy i?iaanoe ioe?ieo noaio
nae?aoe?? iniiaieo ai?iii?a aano?iaioa?iiaie?aaoe/ii? (aano?ei,
niiaoinoaoei, aetheaaii, ?inoe?i), a?iio?ca?ii-iaaeie?eiai? (AEOA,
ei?oeeinoa?ii) oa ii?i?aeii? nenoai (L, M -aieaoae?ie oa (-aiaei?o?i), a
oaeiae oyaeeino? ia?aa?ao caoai?thaaiiy ca iieacieeaie eaoaeueiino?
oaa?ei.

Aea/eoe aieea aiaeia?a iae?iiaioeae?a (aeaea?a?io, iao?io?io, eaiaioaio
oa naiaeinoaoeio) ia ??aaiue nae?aoe?? AEOA, ei?oeeinoa?iio, L,
M-aieaoae?i?a oa (-aiaei?o?io oa aecia/eoe ?o aieea ia ia?aa?a AAI.

Aeine?aeeoe aieea aiaeia?a iae?iiaioeae?a ia ??aaiue nae?aoe?? aano?eio,
niiaoinoaoeio, aetheaaiio, ?inoe?io oa aecia/eoe ?o aieea ia ia?aa?a
AAI.

Aea/eoe aeeiai?eo IIE (ae??iia? eii’thaaoe, iaeiiiaee ae?aeueaeaa?ae) oa
i?ioean?a aioeieneaeaioiiai caoenoo (o?ie-ai?ni? aioeieneaeaioe) a
ne?iaaooe? e?ia? ca oiia ?icaeoeo AAI.

Aeine?aeeoe aieea aiaeia?a iae?iiaioeae?a ia iieacieee IIE oa
aioeieneaeaioiiai caoenoo (AIC) i?ae /an AAI.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa iieacaii aenieo
aioeieneaeaioio aoaeoeai?noue aeaea?a?io i?ioyaii AAI, yea
i?aeaeuo?oueny ca oiia noi?niiai aaeeaaiiy c iao?io?iii, ? iaio ae?acio
aoaeoeai?noue eaiaioaio oa naiaeinoaoeio. Aeiaaaeaii, ui caaaeueieie
iaoai?ciaie e?eoaaeueiiai aoaeoo cacia/aieo i?aia?ao?a, e??i
aeuaaeacaiiai, ? ii?iae?caoe?y aeenaaeaino ai?iiiaeueieo nenoai ?
ca?eueoaiiy aeoeaiino? ii?i?aeii? nenoaie, ui aeyaey? no?an-i?ioaeoi?io
ae?th ca iiaeaeueieo oiia.

Aia?oa anoaiiaeaii, ui ca oiia AAI, aeeeeeaiiai oeyoii ia?aa’ycee
o?aaaeiiiae?aiiai a?ae?inoea, o uo??a niinoa??aa?oueny ?ioaineo?eaoe?y
i?ioean?a a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a, i?i ui na?ae/eoue
ca?eueoaiiy eiioeaio?aoe?? iaeiiiaiai ae?aeueaeaa?aeo oa ae??iiaeo
eii’thaao, a oaeiae i?eai?/aiiy aeoeaiino? AIC. Aeine?aeaeoaaia
aeeiai?ea aeacaieo ci?i i?ioyaii ?icaeoeo AAI iieacaea a?aeiia?aei?noue
?o aaaeeino? caoai?thaaiiy. Aia?oa anoaiiaeaii ciaioaiiy eiioeaio?aoe??
iaeiiiaiai ae?aeueaeaa?aeo oa ae??iiaeo eii’thaao oa ca?eueoaiiy
aeoeaiino? o?ie-ai?uoth/eo aioeieneaeaio?a, a oaeiae ai?noo aano?eio,
AEOA oa ei?oeeinoa?iio i?ae aieeaii aeaea?a?io oa eiai eiia?iaoe?? c
iao?io?iii.

Anoaiiaeaii i?aeaeuaiiy aoaeoeaiino? eiiieaenii? oa?ai?? AAI i?ae
aieeaii canoinoaaiiy aiaeia?a iae?iiaioeae?a.

Iaoeiai-i?aeoe/ia oe?ii?noue ?iaioe iaea?aeaieo ?acoeueoao?a.

?acoeueoaoe ?iaioe iioe?ththoue oyaeaiiy i?i iaoiaaiac AAI, a naia,
na?ae/aoue i?i iaoiaaiaoe/ia cia/aiiy ci?ie nae?aoe?? iniiaieo ai?iii?a
aano?iaioa?iiaie?aaoe/ii? (aano?ei, niiaoinoaoei, aetheaaii, ?inoe?i),
a?iio?ca?ii-iaaeie?eiai? (AEOA, ei?oeeinoa?ii) oa ii?i?aeii? nenoai (L,
M -aieaoae?ie oa (-aiaei?o?i).

Io?eiai? aeai? na?ae/aoue i?i iioei?caoe?th aaeaioaoe?eieo iaoi?ci?a ? ?
iaoiaaiaoe/iei iaa?oiooaaiiyi canoinoaaiiy aiaeia?a iae?iiaioeae?a
(aeaea?a?io, eaiaioaio oa naiaeinoaoeio) oa ?ia?a?oi?o i?ioaac iao?io?io
a eiiieaeniiio e?eoaaii? AAI.

Iniaenoee aianie caeiaoaa/a iieyaa? o aecia/aii? iaoe oa caaaeaiue
aeine?aeaeaiiy, iaa?oiooaaii? e ?ic?iaoe? iaoiae?a ?o ?ica’ycaiiy,
iaoeiaiio aiae?c? e ?ioa?i?aoaoe?? iaea?aeaieo ?acoeueoao?a,
oi?ioethaaii? iniiaieo iieiaeaiue ? aeniiae?a aeena?oaoe??. Aeena?oaoe?y
? naiino?eiith i?aoeath aaoi?a, yea iniaenoi i?iaaea
iaoaioii-?ioi?iaoe?eiee iiooe, aenia?eiaioaeuei? aeine?aeaeaiiy e
cae?enieea noaoenoe/io ia?iaeo io?eiaieo ?acoeueoao?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue
aeeeaaeaii ia ??? I?aeia?iaeiiio eiia?an? c iaoieia?/ii? o?c?ieia??
(Eaoo?, 1998), ?? iaoeia?e eiioa?aioe?? c i?aeia?iaeiith o/anoth
“Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??” (A?iieoey, 1998),
?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeinyaiaiiy oa
iaae??oai? ieoaiiy aano?iaioa?ieia??” (Oa?e?a, 1998) oa II eiia?an?
o??o?a?a Oe?a?ie (Ee?a-Aeiiaoeuee, 1998).

Ioae?eaoe??. Ca iaoa??aeaie aeine?aeaeaiue iioae?eiaaii 7 iaoeiaeo
i?aoeue, c ieo 5 — noaoo? a oaoiaeo aeo?iaeao.

No?oeoo?a oa ianya aeena?oaoe??. ?iaioo aeeeaaeaii ia 133 noi??ieao
iaoeiiieniiai oaenoo. Aiia neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e,
iieno iaoa??ae?a ? iaoiae?a aeine?aeaeaiue, o?ueio ?icae?e?a aeanieo
aeine?aeaeaiue, aiae?co oa ocaaaeueiaiiy ?acoeueoao?a, aeniiae?a ?
nieneo aeei?enoaieo aeaea?ae. Aeena?oaoe?y ?ethno?iaaia 32 oaaeeoeyie oa
15 ?enoieaie. Nienie e?oa?aoo?e i?noeoue 228 aeaea?ae, c ieo — 79
?iicaiieo.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee. Aenia?eiaioaeuei? aeine?aeaeaiiy. Niinoa?aaeaiiy
aoee i?iaaaeai? ia 588 noaoaaic??eeo uo?ao-naioeyo (ianith a?ae 180 aei
250 a) ia iiaeae? aino?iai ia?eoii?oo. AAI a?aeoai?thaaee ca iaoiaeeeith
Eooiaiai A.A. e niaao. (1992, 1995). Ia 1-o aeiao a?ae ii/aoeo
a?aeoai?aiiy o 95% oaa?ei io?eioaaee iae?ineii?/i? iciaee AAI. Aeey
ianooiieo a?io?i?/ieo aeine?aeaeaiue oaa?ei aeaiaeeee c aeine?ae?a ia
1-o, 5-o oa 9-o aeiao (ii 10 uo??a) aeaeai?oaoe??th i?ae ao??iei
ia?eicii. I?e aeaaaeaii? oaa?ei c aenia?eiaioo ia 9-o aeiao o ieo
?ic/eiyee /a?aaio ii?iaeieio oa i?iaiaeeee iae?ineii?/io aa??o?eaoe?th
iayaiino? caiaeueiiai i?ioeano.

Aenia?eiaioe i?iaiaeeee a oaeeo na??yo niinoa?aaeaiue:

1 na??y. Aecia/aiiy eiioeaio?aoe?? a?iio?ca?ii-iaaeie?eiaeo ai?iii?a
(AEOA oa ei?oeeinoa?ii), ai?iii?a aano?iaioa?iiaie?aaoe/ii? ae?eyiee
(aano?ei, niiaoinoaoei, aetheaaii oa ?inoe?i), ii?i?aeieo ai?iii?a (L- ?
M-aieaoae?ie, (-aiaei?o?i), a oaeiae ?ioaineaiino? i?ioean?a IIE o
oaa?ei ?c AAI.

2 na??y. Aecia/aiiy eiioeaio?aoe?? a?iio?ca?ii-iaaeie?eiaeo (AI)
ai?iii?a, ai?iii?a aano?iaioa?iiaie?aaoe/ii? ae?eyiee (AAAIAe),
ii?i?aeieo ai?iii?a (IA), a oaeiae ?ioaineaiino? i?ioean?a IIE o oaa?ei
?c AAI, yeei ianooiii? aeiae uiaeiy iaeii?aciai aaiaeeee aeaea?a?i (50
iea/ea aioo??oiuei/a?aaeiii).

3 na??y. Aecia/aiiy eiioeaio?aoe?? AI, AAAIAe, IA, a oaeiae
?ioaineaiino? i?ioean?a IIE o oaa?ei ?c AAI, yeei ianooiii? aeiae uiaeiy
iaeii?aciai aaiaeeee aeaea?a?i ? iao?io?i (50 iea/ea a//).

4 na??y. Aecia/aiiy eiioeaio?aoe?? AI, AAAIAe, IA, a oaeiae
?ioaineaiino? i?ioean?a IIE o oaa?ei ?c AAI, yeei ianooiii? aeiae uiaeiy
iaeii?aciai aaiaeeee eaiaioai (50 iea/ea a//).

5 na??y. Aecia/aiiy eiioeaio?aoe?? AI, AAAIAe, IA, a oaeiae
?ioaineaiino? i?ioean?a IIE o oaa?ei ?c AAI, yeei ianooiii? aeiae uiaeiy
iaeii?aciai aaiaeeee naiaeinoaoei (50 iea/ea a//).

Eiio?ieueieie aoee aea? a?oie oaa?ei — caei?ia? (?ioaeoi?) uo?e, yeei
oaiaeeee aiaeia?/i? ia’?ie 0.9% ?ic/eio NaCl, ? uo?e ?c AAI, yeei
e?eoaaiiy ia i?iaiaeeeiny, a aaiaeeeeny oae? naii ia’?ie 0.9% ?ic/eio
NaCl. I?ioyaii onueiai aenia?eiaioo i?ae?aoiaoaaee e?euee?noue caaeaeeo
oaa?ei, a?aoiaoth/e ?iciiae?e eaoaeueiino? ii a?oiao.

A ie?ai?e na??? niinoa?aaeaiue i?iaiaeeee ii??aiyeueiee aiae?c
aoaeoeaiino? aaciai? oa?ai?? (canoinoaaiiy aii?ieno, 25000 IA/ea, a//)
ca oiia aeiaeaiiy aei e?eoaaeueiiai eiiieaeno aeaea?a?io c iao?io?iii.

Ca aeiiiiiaith a?io?i?/ieo cania?a aeine?aeaeaiiy a ne?iaaooe? e?ia?
oaa?ei caniaii ?aae?i?ioiiiai aiae?co (??A; R.Yalow, S.Bensson, 1960)
aecia/aee eiioeaio?aoe?? AI, AAAIAe, IA. ??A cae?enithaaee ca
aeiiiiiaith noaiaea?oieo iaai??a o??i DRG (NOA), Sorrin (O?aioe?y),
Cambridge ? Amersham (Aiae?y), Immuno Nuclear Corporation (NOA).

Aecia/aiiy ae??iiai? eii’thaaoe?? (AeE) iaiane/aieo aeueo aee?ieo eeneio
? e?euee?noue o?ieiaeo aioeieneaeaio?a (OA; ai?no SH- oa SS-a?oi)
cae?enithaaee ca ?.Ae.Noaeueiith (1977). Eiioeaio?aoe?th iaeiiiaiai
ae?aeueaeaa?aeo (IAeA) aecia/aee ca aeiiiiiaith o?iaa?a?oo?iai? eeneioe
(E.Ae.Noaeueiay e niaao., 1977).

Noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiiy i?iaiaeeeanue ?c
canoinoaaiiyi caaaeueiii?eeiyoeo o iaaeeei-a?ieia?/ieo aeine?aeaeaiiyo
ia?aiao?e/ieo ? iaia?aiao?e/ieo cania?a noaoenoe/iiai aiae?co (Ao?ao ss.
e niaao., 1991) ia ia?niiaeueiiio eiii’thoa?? ca aeiiiiiaith i?ia?aie
noaoenoe/iiai aiae?co. A??ia?aeieie aaaaeaee ci?ie i?e P<0.05. Aieea aiaeia?a iae?iiaioeae?a ia eaoaeuei?noue oa noai i?ioean?a IIE i?ae /an AAI Ia 1-o aeiao a?ae ii/aoeo caoai?thaaiiy eaoaeuei?noue a eiio?ieuei?e a?oi? noaiiaeea 60% (?en. 1, A). I?aeoe/ii iaeiaeia? iieacieee eaoaeueiino? (ia 20-24% iaio? ca eiio?ieuei?) aoee a a?oiao oaa?ei ?c AAI, yeei oaiaeeee aii?ien c aeaea?a?iii oa aeaea?a?i. Eaoaeuei?noue a a?oiao oaa?ei ?c AAI, yeei canoiniaoaaee aii?ien, oa aeaea?a?i c iao?io?iii, noaiiaeee, a?aeiia?aeii, 32% ? 27% (P<0.05). Ia 5-o aeiao ia?aa?ao caoai?thaaiiy o?eaaei cieaeaiiy (a 2.4 ?ace, P<0.01) eaoaeueiino? a a?oi? oaa?ei ?c AAI, yeei i?iaiaeeee eiia?iiaaia aaeeaaiiy aeaea?a?io c iao?io?iii. Eaoaeuei?noue o eiio?ieuei?e a?oi? uo??a ?c AAI ia 9-o aeiao ia?aa?ao caoai?thaaiiy noaiiaeea 87%. ?c 36 uo??a, yeei oaiaeeee aeaea?a?i, aei aeaa'yoi? aeiae aeaeeee 15 (?en. 1, A). Ioaea, iieacieee eaoaeueiino? cieceeeny ia 27% ii??aiyii c oaeeie a eiio?ie? (P<0.05). O aeiaaeeo ii?aeiaiiai aaeeaaiiy aeaea?a?io c iao?io?iii a?aei?/aeeny iaeiaio? iieacieee eaoaeueiino? aenia?eiaioaeueieo oaa?ei ye o ii??aiyii? c eiio?ieueieie aeaieie (a 2.1 ?aco iaioa; P<0.01), oae ? c aiaeia?/ieie ?acoeueoaoaie a a?oi? uo??a, ui iaea?aeoaaee aeaea?a?i (ia 20% iaioa; P<0.05). Oaeei /eiii, on? i?aia?aoe oa eiiieaene i?aia?ao?a, ui aeine?aeaeothoueny, cieaeoaaee eaoaeuei?noue aenia?eiaioaeueieo oaa?ei ii/eiath/e c 1-? aeiae caoai?thaaiiy. Ne?ae cacia/eoe, ui iaeiaio? iieacieee eaoaeueiino? aoee io?eiai? ca oiia ii?aeiaiiai aaeeaaiiy aeaea?a?io c iao?io?iii. Ia?o? 24 aiae a?ae ii/aoeo ?iaeoeoe?? AAI oa?aeoa?ecothoueny iaeiie/aiiyi i?iaeoeo?a a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a (?en. 1, A). Eiioeaio?aoe?y IAeA a ne?iaaooe? e?ia? noaiiaeea 3.61(0.09 iiieue/e, ui a 2.4 ?aco ia?aaaaeaei oaeee iieaciee o eiio?ieuei?e a?oi? ?ioaeoieo oaa?ei (P<0.01). ?acii c oeei, ??aaiue AeE aoa ca?eueoaiee ia 73% (P<0.05) ii??aiyii c eiio?ieai. *a?ac 5 ae?a a?ae /ano a?aeoai?aiiy AAI eiioeaio?aoe?y IAeA c?inea a 4 ?ace (P<0.001) ii??aiyii c eiio?ieai ? a 1.7 ?aco ii??aiyii c oaeeie iieacieeaie /a?ac 24 aiae a?ae iiiaioo a?aeoai?aiiy ia?eoii?oo (P<0.05). Aaee/eia AeE o ne?iaaooe? e?ia? uo??a noaiiaeea 0.90±0.06 ieiieue/a, ui aoei a 2.2 ?aco a?eueoa i?ae a eiio?ieuei?e a?oi? oaa?ei. Ca oeae ?ioa?aae /ano ?noioii (a 2.2 ?aco; P<0.001) cieceeany e?euee?noue OA ii??aiyii c oaeeie aeaieie a eiio?ie?. Ne?ae cacia/eoe, ui ci?ia aeaiiai iieacieea ii??aiyii c oaeei ca 24 aiae i?ney ?iaeoeoe?? AAI oaeiae aoea ?noioiith (a 2.4 ?aco; P<0.001). Ia 9-o aeiao ia?aa?ao AAI eiioeaio?aoe?? IAeA ? AeE o ne?iaaooe? e?ia? aenia?eiaioaeueieo oaa?ei noaiiaeee, a?aeiia?aeii, 5.21±0.08 iiieue/e ? 0.69±0.11 ieiieue/a, ui aoei a 3.5 ?aco (P<0.001) oa a 1.7 ?aco (P<0.05) a?eueoei ca iieacieee a eiio?ieuei?e a?oi?. Eiioeaio?aoe?y OA i?aeaeuoaaeany ii??aiyii c oaeei iieacieeii ia 5-o aeiao ia 76% (P>0.05;
?en. 1, A).

Oaeei /eiii, io?eiai? ?acoeueoaoe na?ae/aoue i?i ??cea i?aeneeaiiy
?ioaineaiino? i?ioean?a IIE o ne?iaaooe? e?ia? uo??a ca oiia AAI. ?acii
c oeei a?aeaoaa?oueny i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino?
aioeieneaeaioii? nenoaie.

*a?ac 24 aiae a?ae /ano a?aeoai?aiiy AAI i?ae aieeaii a// canoinoaaiiy
aeaea?a?io aecia/aeiny cieaeaiiy ia 40% ??aiy IAeA ii??aiyii c oaeei o
uo??a c ia?eoii?oii aac canoinoaaiiy i?aia?ao?a (P<0.001). Ca oeeo oiia eiioeaio?aoe?y AeE ciaiooaaeany ia 31% ii??aiyii c oaeith o uo??a ?c AAI (P<0.05). I?ney ii?aeiaiiai aaeeaaiiy aeaea?a?io c iao?io?iii ??aaiue IAeA noaiiaea 2.33+0.06 iiieue/e, ui ia 35% aoei iaioei a?ae aiaeia?/iiai iieacieea o uo??a ?c AAI (P<0.05). I?ae aieeaii aeaea?a?io c iao?io?iii ia 30% cieceeany eiioeaio?aoe?y AeE ? ia 28% c?inea e?euee?noue OA a ne?iaaooe? e?ia? uo??a (P<0.05). Eaiaioai ia 16% (P<0.05) ciecea ??aaiue IAeA ? ia aieeaaa ia e?euee?noue AeE ? OA (P>0.05). Ca oiia canoinoaaiiy naiaeinoaoeio eiioeaio?aoe?y IAeA ? AeE
noaiiaeea, a?aeiia?aeii, 2.85+0.10 iiieue/e ? 0.52+0.11 ieiieue/a, ui ia
89% ? 27% ia?aaeuoaaei oae? aeai? a eiio?ie? (P<0.05). Oaeei /eiii, aoaeo cieaeaiiy ai?noo i?iaeoeo?a IIE (IAeA oa AeE), a oaeiae i?aeaeuaiiy ??aiy OA i?ae aieeaii iae?iiaioeae?a aeyaeyany i?ioyaii onueiai niinoa?aaeaiiy (aei 9-? aeiae aeeth/ii). I?e/iio iaea?eueoa aoaeoeai?noue aeyaeyeanue i?e noi?niiio aeei?enoaii? aeaea?a?io c iao?io?iii, iaioa - i?e aeei?enoaii? ie?aii aeaea?a?io oa naiaeinoaoeio. Ioaea, iiaeia c?iaeoe aeniiaie i?i ciaioaiiy ?ioaineaiino? i?ioean?a IIE oa i?aeaeuaiiy aeoeaiino? AIC i?ae aieeaii aeaea?a?io. Cacia/aiee aoaeo aeaea?a?io iineethaaany o ?ac? eiai eiia?iaoe?? c iao?io?iii. Iacia/io aioeieneaeaioio aeoeai?noue aeyaey? naiaeinoaoei. Aieea aiaeia?a iae?iiaioeae?a ia ??aaiue ai?iii?a i?ae /an AAI ??aaiue nae?aoe?? aano?eio a ia?oo aeiao caoai?thaaiiy c?inoaa ia 62% ii??aiyii c oaeei iieacieeii o a?oi? ?ioaeoieo oaa?ei (P<0.05). O iiaeaeueoiio aeeiai?ea c?inoaiiy eiioeaio?aoe?? aano?eio caa??aa?oueny. Oae, ia 5-o aeiao ?icaeoeo AAI ??aaiue eiai nae?aoe?? noaiiaea 119.1±12.7 ia/ie, ui aeyaeeiny a 2.2 ?aco aeua a?ae oaeiai eiio?ieueiiai iieacieea (P<0.01). Ia 9-o aeiao aeaiee iieaciee aoa ia 48% aeuei ca aiaeia?/iee iieaciee o a?oi? eiio?ieueieo oaa?ei aac AAI (P>0.05).

Eiioeaio?aoe?y niiaoinoaoeio a e?ia? oaa?ei eiio?ieueii? a?oie noaiiaeea
16.0±5.5 ia/ie. C ?icaeoeii AAI aecia/aeiny cieaeaiiy ??aiy nae?aoe??
iae?iiaioeaeo. Oae, ia 1-o aeiao aaee/eia aeaiiai iieacieea aoea ia 24%
iaioith ca oaeee iieaciee o eiio?ie? (P>0.05), ia 5-o aeiao — ia 37%
iaioith ca oaeee iieaciee o eiio?ie? (P>0.05) ? ia 9-o aeiao
eiioeaio?aoe?y niiaoinoaoeio noaiiaeea 13.6±6.7 ia/ie, ui aoei ia 15%
iaioa a?ae oaeiai iieacieea o uo??a uiaei eiio?ieueieo niinoa?aaeaiue.

Oaea ae naia ni?yioaaiiy iaea aeeiai?ea ci?i iieaciee?a ai?noo
niiaoinoaoeio, aetheaaiio e ?inoe?io, a oie /an, ye eiioeaio?aoe?y
aano?eio iaea i?ioeeaaeio ca nai?th ni?yiiaai?noth aeeiai?eo.

*a?ac 24 aiae i?ney a?aeoai?aiiy aino?i? iaoieia?? o /a?aai?e ii?iaeiei?
eiioeaio?aoe?y AEOA ia?aaeuoaaea oaeo a eiio?ieuei?e a?oi? oaa?ei a 2.1
?aco (P<0.01). Ia 5-o aeiao a?ae iiiaioo iiaeaethaaiiy AAI ??aaiue AEOA aeinya naiai iaeneioio oa noaiiaea 99.8±10.1 ia/ie, ui aoei a 2.3 ?aco aeua ca aiaeia?/iee iieaciee o eiio?ieueieo niinoa?aaeaiiyo (P<0.01). ??aaiue nae?aoe?? AEOA caeeoaany ?noioii i?aeaeuaiei ? ia 9-o aeiao niinoa?aaeaiiy oeae iieaciee noaiiaea 80.9±13.7 ia/ie, ui a 1.8 ?aco ia?aaeuoaaei oae? cia/aiiy a ne?iaaooe? uo??a eiio?ieueii? a?oie (P<0.05). Eiioeaio?aoe?y ei?oeeinoa?iio a ne?iaaooe? ?ioaeoieo uo??a (eiio?ieueia a?oia) noaiiaeea 210.1±31.1 ia/ie. Ia 1-o aeiao o uo??a c AAI oeae iieaciee ia?aaeuoaaa oaeee o eiio?ie? ia 75% (P<0.05). Ia 5-o oa 9-o aeiao a?ae iiiaioo a?aeoai?aiiy AAI iieaciee, ui aeine?aeaeoaaany, ia?aaeuoaaa oae? eiio?ieuei? aaee/eie, a?aeiia?aeii, ia 81% oa 72% (P<0.05). *a?ac 24 aiae i?ney a?aeoai?aiiy AAI eiioeaio?aoe?y L- oa M-aieaoae?i?a noaiiaeea 61.9±28.8 ia/ie, ui aoei ia 42% iaioa ca oaeee iieaciee o eiio?ie? (P>0.05). Ia 5-o aeiao ??aaiue nae?aoe?? L- oa
M-aieaoae?i?a aoa iaioei ca eiio?ieuei? aaee/eie ia 27%, ia 9-o aeiao —
ia 13% (P>0.05). Oaea ae naia ni?yioaaiiy iaee ci?ie nae?aoe??
(-aiaei?o?i?a ia 1-o, 5-o oa 9-o aeiao i?ney a?aeoai?aiiy AAI.

Ioaea, ia?aa?a AAI noi?iaiaeaeo?oueny aeenaaeainii nae?aoi?ii?
aeoeaiino? ai?iii?a AI ooieoe?iiaeueii? nenoaie, a oaeiae IA. Iiaeia
aaaaeaoe, ui c?inoaiiy a aeeiai?oe? AAI ooieoe?iiaeueii? aeoeaiino?
o?c?ieia?/ii? in? “a?iioaeaion-a?iio?c-iaaeie?eia? caeice” ? i?iyaii
aeoeaiino? eiiiainaoi?ii-i?enoinoaaeueieo iaoai?ci?a.

A oie aea /an cieaeaiiy ooieoe?iiaeueii? aeoeaiino? aiaeiaaiii?
ii?i?aeii? nenoaie iiaeeeai o?aeooaaoe ye i?eai?/aiiy no?an-e?i?ooth/i?
ii?i?aeii? nenoaie.

I?ae aieeaii aeaea?a?io /a?ac 24 aiae i?ney a?aeoai?aiiy AAI a
ne?iaaooe? e?ia? uo??a aacaeueiee ??aaiue nae?aoe?? aano?eio aoa iaioee
ia 31% (P<0.05) ii??aiyii c oaeei a a?oi? uo??a ?c AAI, aea aac e?eoaaiiy. O aeiaaeeo ii?aeiaiiai canoinoaaiiy aeaea?a?io c iao?io?iii eiioeaio?aoe?y aano?eio cieceeany ia 42%. ?noioia cieaeaiiy ??aiy aacaeueii? nae?aoe?? aano?eio (ia 26%; P<0.05) i?ioyaii 1-? aeiae i?ney iiaeaethaaiiy aino?i? iaoieia?? o /a?aai?e ii?iaeiei? aecia/aeiny oaeiae aiane?aeie aaeeaaiiy eaiaioaio. Ii?iae?caoe?th iieaciee?a eiioeaio?aoe?? aano?eio aoei aeyaeaii o aeiaaeeo canoinoaaiiy naiaeinoaoeio: iieaciee, ui aeine?aeaeo?oueny, noaiiaea 59.8±7.4 ia/ie, ui aoei ia 36% iaioa oaeiai a a?oi? oaa?ei ?c AAI aac e?eoaaiiy (P<0.05) oa ia a?ae??ciyeiny a?ae oaeiai iieacieea a eiio?ieuei?e a?oi? uo??a (P>0.05.

I?ioyaii ia?oeo 24 aiae ia?aa?ao AAI aecia/aeiny cieaeaiiy ??aiy
nae?aoe?? niiaoinoaoeio ia 24% (P>0.05). O uo??a, yeei oaiaeeee
aeaea?a?i, oeae iieaciee ii??aiyii c oaeei o a?oi? uo??a ?c AAI aac
e?eoaaiiy, c??n ia 21% (P>0.05). O aeiaaeeo ii?aeiaiiai canoinoaaiiy
aeaea?a?io c iao?io?iii iieacieee, ui aeine?aeaeothoueny, a iaio a?oiao
ia a?ae??ciyeeny (?>0.05). Eaiaioai ni?eya ca?eueoaiith eiioeaio?aoe??
niiaoinoaoeio ia 31%, a naiaeinoaoei — ia 17% (?>0.05).

*a?ac 24 aiae i?ney a?aeoai?aiiy AAI eiioeaio?aoe?y aetheaaiio o uo??a
i?ae aieeaii aeaea?a?io i?aeoe/ii ia ci?ieeany (?>0.05). A iiaeaeueoiio
oaeiae ia aoei a?aei?/aii ?noioieo ci?i iieacieea, ui aeine?aeaeo?oueny.
Aiaeia?/i? ?acoeueoaoe aoee io?eiai? i?ae /an aeine?aeaeaiiy aieeao
iae?iiaioeae?a ia eiioeaio?aoe?th ?inoe?io.

Ia 5-o aeiao i?ney a?aeoai?aiiy AAI eiioeaio?aoe?y aano?eio a 2.2 ?aco
(P<0.01) ia?aaeuoaaea aiaeia?/iee iieaciee o eiio?ieuei?e a?oi? uo??a. A a?oi? uo??a ?c canoinoaaiiyi aeaea?a?io aaee/eia aeaiiai iieacieea noaiiaeea 63.3(6.1 ia/ie, ui ia 9% ia?aaeuoaaei oaeee eiio?ieueiee iieaciee (P>0.05) ? aoei a 1.9 ?aco iaioa a?aeiia?aeiiai iieacieea a
a?oi? uo??a ?c AAI aac e?eoaaiiy (P<0.05). Ii?aeiaia canoinoaaiiy uo?ai ?c AAI aeaea?a?io oa iao?io?io ni?eyei ii?iae?caoe?? iieacieea, ui aeine?aeaeo?oueny (P>0.05 ii??aiyii c eiio?ieueieie niinoa?aaeaiiyie),
oa ?noioiiio (a 2.3 ?aco) eiai cieaeaiith ii??aiyii c oaeei o uo??a ?c
AAI aac e?eoaaiiy (P<0.05). O aeiaaeeo canoinoaaiiy eaiaioaio aaee/eia nae?aoe?? aano?eio noaiiaeea 62.5±10.4 ia/ie, ui aoei a 2 ?ace iaioei, i?ae o uo??a ?c AAI aac e?eoaaiiy (P<0.05), ? ia a?ae??ciyeiny a?ae oaeiai iieacieea a eiio?ie? (P>0.05). Ca oiia oaeeaaiiy naiaeinoaoeio
aecia/aeiny cieaeaiiy iieacieea, ui aeine?aeaeo?oueny, a 2.1 ?aco
(P<0.05). I?ae aieeaii aeaea?a?io aaee/eia eiioeaio?aoe?? niiaoinoaoeio aoea ia 24% aeuith, i?ae a a?oi? uo??a ?c AAI aac e?eoaaiiy (P>0.05). A aeaiiio
aeiaaeeo ??aaiue nae?aoe?? niiaoinoaoeio aoa ia 14% aeuei, i?ae a
eiio?ie? (P>0.05). I?ney canoinoaaiiy aeaea?a?io ?acii c iao?io?iii
aacaeueiee ??aaiue nae?aoe?? niiaoinoaoeio i?aeaeueany ia 13% ii??aiyii
c oaeei o ne?iaaooe? uo??a ?c AAI, yeei ia cae?enithaaee e?eoaaiiy
(P>0.05). O aeiaaeeo aaeeaaiiy eaiaioaio iieacieee, ui
aeine?aeaeothoueny, a iaio a?oiao ia a?ae??ciyeeny ?noioii (P>0.05). O
a?oi? uo??a, yeei cae?enithaaee aaaaeaiaiy naiaeinoaoeio, eiioeaio?aoe?y
niiaoinoaoeio noaiiaeea 19.7±5.2 ia/ie, ui aoei ia 22% a?eueoa i?ae
aiaeia?/iee iieaciee o uo??a, yeei ca oiia AAI ia i?ecia/aee e?eoaaiiy
(P>0.05).

*a?ac 5 ae?a i?ney a?aeoai?aiiy AAI eiioeaio?aoe?y aetheaaiio noaiiaeea
55.5±6.7 ia/ie, ui aoei ia 26% iaioei (P>0.05), i?ae oaeee naii iieaciee
o eiio?ieuei?e a?oi? uo??a (aac a?aeoai?aiiy AAI). A a?oi? uo??a ?c
canoinoaaiiyi aeaea?a?io aaee/eia aeaiiai iieacieea noaiiaeea 59.3±6.6
ia/ie, ui aoei ia 20% iaioa a?ae oaeiai iieacieea a eiio?ie? (P>0.05) ?
ia 6% ia?aaeuoaaei aiaeia?/iee iieaciee o a?oi? uo??a ?c AAI aac
e?eoaaiiy (P>0.05). Ii?aeiaia canoinoaaiiy aeaea?a?io c iao?io?iii
ni?eyei cieaeaiith ia 33% iieacieea, ui aeine?aeaeo?oueny (P>0.05
ii??aiyii c eiio?ieueieie niinoa?aaeaiiyie), ? ciaioaiith eiai ia 6%
ii??aiyii c oaeei o uo??a ?c AAI aac e?eoaaiiy (P>0.05). O aeiaaeeo
canoinoaaiiy eaiaioaio aaee/eia nae?aoe?? aetheaaiio noaiiaeea 53.8±5.2
ia/ie, ui ia a?ae??ciyeiny a?ae oaeiai iieacieea o uo??a ?c AAI aac
e?eoaaiiy (P>0.05). Ca oiia oaeeaaiiy naiaeinoaoeio aecia/aeiny
cieaeaiiy iieacieea, ui aeine?aeaeo?oueny, ia 25% ii??aiyii c
eiio?ieueiei cia/aiiyi (P>0.05).

I’yoa aeiaa ia?aa?ao AAI noi?iaiaeaeoaaeany cieaeaiiyi ia 20% (P>0.05)
eiioeaio?aoe?? ?inoe?io ii??aiyii c oaeei iieacieeii o eiio?ie?. A on?o
aeine?aeaeoaaieo a?oiao uo??a, yeei cae?enithaaee aaaaeaiiy aiaeia?a
iae?iiaioeae?a, ??aaiue nae?aoe?? ?inoeeio ia a?ae??ciyany ?noioii a?ae
oaeiai iieacieea a eiio?ie? (P>0.05).

Oaea ae naia ni?yioaaiiy iaee ?acoeueoaoe uiaei aeine?aeaeaiiy aieeao
aiaeia?a iae?iiaioeae?a ia ??ai? ai?iii?a, ui aeine?aeaeothoueny,
io?eiaieo ia 9-o aeiao i?ney a?aeoai?aiiy AAI.

O a?oi? uo??a ?c aaaaeaiiyi aeaea?a?io aecia/aeiny cieaeaiiy ??aiy
nae?aoe?? AEOA ia 15% (P>0.05) ii??aiyii c oaeei o a?oi? uo??a ?c AAI
aac e?eoaaiiy. Oeae iieaciee caeeoaany ?noioii aenieei (ia 80%; P<0.05) ii??aiyii c aiaeia?/iei o eiio?ieuei?e a?oi? oaa?ei (uo?e aac AAI). O aeiaaeeo ii?aeiaiiai canoinoaaiiy aeaea?a?io c iao?io?iii eiioeaio?aoe?y AEOA cieceeany ia 28% ? noaiiaeea 68.4±10.9 ia/ie. Cieaeaiiy ??aiy aacaeueii? nae?aoe?? AEOA (ia 22%; P>0.05) a?aei?/aeiny i?ioyaii 1-?
aeiae i?ney iiaeaethaaiiy aino?i? iaoieia?? a /a?aai?e ii?iaeiei? i?ney
canoinoaaiiy eaiaioaio. I?e aeei?enoaii? naiaeinoaoeio iieaciee, ui
aeine?aeaeo?oueny, noaiiaea 68.4±10.8 ia/ie, ui aoei ia 28% iaioa i?ae o
a?oi? oaa?ei ?c AAI aac e?eoaaiiy (P>0.05).

I?e aeine?aeaeaii? ??aiy nae?aoe?? ei?oeeinoa?iio i?ioyaii ia?oeo 24
aiae AAI a?aei?/aeiny eiai ca?eueoaiiy a 1.75 ?aco (P<0.05). O uo??a, yeei oaiaeeee aeaea?a?i, oeae iieaciee ii??aiyii c oaeei o a?oi? uo??a ?c AAI aac e?eoaaiiy cieceany ia 17% (P>0.05), aea ua ia?aaeuoaaa a 1.5
?aco aiaeia?/iee iieaciee o eiio?ie? (P<0.05). O aeiaaeeo ii?aeiaiiai canoinoaaiiy aeaea?a?io c iao?io?iii iieaciee, ui aeine?aeaeo?oueny, noaiiaea 274.2±36.8 ia/ie, ui aoei ia 25% iaioa a?ae oaeiai iieacieea a a?oi? uo??a ?c AAI aac e?eoaaiiy oa ia a?ae??ciyeiny a?ae oaeiai iieacieea a eiio?ie? (P>0.05). Eaiaioai ni?eya cieaeaiith eiioeaio?aoe??
AEOA ia 13% ii??aiyii c oaeei iieacieeii o uo??a ?c AAI aac e?eoaaiiy.
Aiaeia?/iee iieaciee o aeiaaeeo canoinoaaiiy naiaeinoaoeio noaiiaea 29%
(?>0.05).

?icaeoie AAI i?ae /an ia?oeo 24 aiae noi?iaiaeaeoaaany iacia/iei (ia
49%) cieaeaiiyi eiioeaio?aoe?? (-aiaei?o?io (P>0.05). I?ney canoinoaaiiy
aiaeia?a iae?iiaioeae?a aeaiee iieaciee ia a?ae??ciyany ?noioii a
aeine?aei?e oa a iaio eiio?ieueieo a?oiao i?ioyaii onueiai oa?i?io
niinoa?aaeaiiy.

*a?ac 24 aiae c iiiaioo a?aeoai?aiiy AAI eiioeaio?aoe?y L- ?
M-aieaoae?i?a noaiiaeea 61.9±28.8 ia/ie, ui aoei ia 42% iaioa
aiaeia?/iiai iieacieea a eiio?ieuei?e a?oi? oaa?ei (P>0.05). I?ney
canoinoaaiiy aiaeia?a iae?iiaioeae?a eiioeaio?aoe?y aieaoae?i?a ia
a?ae??ciyeany ?noioii a aeine?aei?e oa a iaio eiio?ieueieo a?oiao
i?ioyaii onueiai oa?i?io niinoa?aaeaiiy.

?acoeueoaoe iaoeo aeine?aeaeaiue i?aeoaa?aeaeothoue aeoieo i?i
aoaeoeai?noue aeei?enoaiiy aeaea?a?io oa eiai ii?aeiaiiy c iao?io?iii ca
oiia AAI. Oae, i?ae /an canoinoaaiiy icia/aieo iae?iiaioeae?a
ii?iae?coaaeany eiioeaio?aoe?y AEOA oa ei?oeeinoa?iio.

Caaaeath/e ia anoaiiaeaio aeeiai?eo ??aiy ai?iii?a, nooi?iue ii?ooaiiy
yei? a?aeiia?aea? aaaeeino? ia?aa?ao AAI, aoei aeine?aeaeaii oa?aeoa?
ai?iiiaeueieo c?ooaiue ia aoai? aeaeoaeaiiy ca oiia canoinoaaiiy aaciai?
oa?ai?? AAI ca aeiiiiiaith aii?ieno. Ca oeeo oiia, ye na?ae/aoue
?acoeueoaoe, iiaeai? ia ?en. 1, eaoaeuei?noue ia 9-o aeiao noaiiaeea 87%
(P<0.05), a ??aaiue ai?iii?a (aeea. ?en. 2) cieaeoaaany a na?aaeiueiio ia 15-27% ii??aiyii c aiaeia?/ieie iieacieeaie a a?oi? oaa?ei ?c AAI aac e?eoaaiiy (P<0.05). Caeo/aiiy aei aaciai? oa?ai?? eiiieaeno c aeaea?a?iii oa iao?io?iii i?ecaaei aei cieaeaiiy eaoaeueiino? ia 9-o aeiao a 2.1 ?aco (P<0.01), ui ieae/a ca oaeee iieaciee o a?oi? uo??a, yeei i?ecia/aee eeoa aaciao oa?ai?th. Eiiieaenia aaeeaaiiy aeaea?a?io c iao?io?iii ni?eyei cieaeaiith ??aiy nae?aoe?? aano?eio ia 5-o aeiao ia?aa?ao AAI ia 56% ii??aiyii c aiaeia?/iei iieacieeii a a?oi? oaa?ei ?c AAI aac e?eoaaiiy (P<0.05), ui aoei ia 40% a?eueoei ii??aiyii c oaeei iieacieeii a a?oi? oaa?ei ?c AAI, yeei canoiniaoaaee aii?ien (P<0.05). ??aaiue nae?aoe?? AEOA i?ae aieeaii canoinoaaiiy aeaea?a?io c iao?io?iii cieceany ia 36% ii??aiyii c aiaeia?/iei iieacieeii a a?oi? oaa?ei ?c AAI aac e?eoaaiiy (P<0.05). Aeiaeaiiy aei aaciai? oa?ai?? eiiieaeno aeaea?a?io c iao?io?iii ni?eyei cieaeaith ??aiy nae?aoe?? ei?oeeinoa?iio ia 37% ii??aiyii c oaeei iieacieeii a a?oi? oaa?ei ?c AAI aac e?eoaaiiy (P<0.05). Ca cacia/aieo oiia aoaeoeai?noue eiiieaeniiai canoinoaaiiy aeaea?a?io c iao?io?iii ia?aaeuoaaea oaeo a a?oiao oaa?ei ?c AAI, yeei canoiniaoaaee aii?ien (P<0.05; ?en. 2). Oaeei /eiii, canoinoaaiiy a eiiieaeniiio e?eoaaii? aeaea?a?io c iao?io?iii i?aeaeuo? ?? aoaeoeai?noue, ui ? aenia?eiaioaeueiei iaa?oiooaaiiyi ee?i?/iiai canoinoaaiiy iae?iiaioeae?a o o??o?a?/i?e ee?i?oe? ye neeaaeiaa /anoeia eiiieaeniiai e?eoaaiiy i?ioyaii i?neyiia?aoe?eiiai ia??iaea o oai?eo ?c ?iceeoei ai?eiei ia?eoii?oii. AENIIAEE Ca oiia AAI, ?iaeoeiaaiiai o uo??a ia?aa’yceith o?aaaeia?aeiiai a?ae?inoeo, o ne?iaaooe? e?ia? a?i?/a?oueny ??cea i?aeneeaiiy i?ioean?a a?eueii?aaeeeaeueiiai ieeneaiiy, ui i?iyaey?oueny ca?eueoaiiyi eiioeaio?aoe?e IAeA e AeE, oa i?eai?/aiiy aeoeaiino? aioeieneaeaioii? nenoaie, ui i?iyaey?oueny ciaioaiiyi ai?noo o?ieiaeo a?oi. Cacia/ai? ci?ie aeinyaathoue iaeneioio ia 5-o aeiao c iiiaioo aeieeiaiiy caoai?thaaiiy oa noi?iaiaeaeothoueny aenieith eaoaeuei?noth. Ca oiia AAI o?eaa? aeoeaaoe?y aano?iaioa?iiaie?aaoe/ii? ? a?iio?ca?ii-iaaeie?eiai? oa i?eai?/aiiy aeoeaiino? ii?i?aeii? ai?iiiaeueieo nenoai. Cacia/ai? ci?ie nae?aoi?ii? aeoeaiino? a?aei?/athoueny /a?ac 24 aiaeeie i?ney AAI oa iaaoaathoue iaeneioio ia 5-o aeiao. Aeeiai?ea ??aiy aano?eio, niiaoinoaoeio, ?inoe?io, aetheaaiio, AEOA, ei?oeeinoa?iio, a oaeiae aieaoae?i?a oa (-aiaei?o?io a?aeiia?aea? aeeiai?/iiio oa?aeoa?o iieaciee?a ii?ooaiue IIE oa AIC, a oaeiae aaaeeino? ia?aa?ao caoai?thaaiiy ca iieacieeaie eaoaeueiino?. Canoinoaaiiy uo?ai ca oiia AAI aeaea?a?io ni?eyei i?eai?/aiith ?ioaineaiino? i?ioean?a IIE e aeoeaaoe?? nenoaie aioeieneaeaioiiai caoenoo. Iaio ae?acio aioeieneaeaioio aeoeai?noue aeyaeyee eaiaioai oa naiaeinoaoei. Aaeeaaiiy uo?aie ?c AAI aeaea?a?io ii?iae?coaaei ?iaeoeiaaia iaoieia?/iei noaiii c?ooaiiy nae?aoi?ii? aeoeaiino? aano?iaioa?iiaie?aaoe/ii? oa a?iio?ca?ii-iaaeie?eiai? ai?iiiaeueieo nenoai. Aiaeia?/io, aea iaio ae?acio ae?th aeyaeyee eaiaioai oa naiaeinoaoei. Canoinoaaiiy ?iaea?oi?o i?ioaac iao?io?io i?aeneethaaei aoaeoeai?noue aeaea?a?io, ui ae?aaeaeinue o ii?iae?caoe?? aeenaaeaino o nenoai? IIE-AIC, iie?auoaaei noai iae?iaiaeie?eiii? ?aaoeyoe??, cieaeoaaei eaoaeuei?noue oaa?ei oa iie?auoaaei ia?aa?a caoai?thaaiiy. Iie?auaiiy ia?aa?ao AAI oa cia/ia cieaeaiiy iieaciee?a eaoaeueiino? oaa?ei i?ae aieeaii aiaeia?a iae?iiaioeae?a aeaea?a?io, eaiaioaio, naiaeinoaoeio oa ?ia?a?oi?o i?ioaac iao?io?io na?ae/eoue i?i iioei?caoe?th aaeaioaoe?eieo iaoai?ci?a ca oiia aeaii? iaoieia?? oa ? aenia?eiaioaeueiei iaa?oiooaaiiyi ?o caeo/aiiy aei eiiieaenii? oa?ai?? ia?eoii?oo. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? Aioeieneaeaioi? aoaeoe eiiieaeniiai canoinoaaiiy aeaea?a?io ca oiia aino?iai aenia?eiaioaeueiiai ia?eoii?oo o uo??a // Iaeanueeee iaaee/iee aeo?iae. -1998. -?4. -N.9-13. Sandostatin improves stress-induced changes of hormonal content in rats with acute peritonitis // Pathophysiology. -1998. -Vol.5, Suppl.1. -S.150. (o ni?aaao. c A.I.Aeaieaeiaei, ?.I.Eeaiaioue?aei, N.A.Oeeiia'ycii, I.A.Neiiaoeai). Nia?aiaiiua oaiaeaioeee a ea/aiee ino?iai iaie?aaoeoa // Aiiaeu oe?o?ae/aneie aaiaoieiaee. -1998. -O.3, ?3. -N.320. (o ni?aaao. c ?.I.Eeaiaioue?aei, N.A.Oeeiia'ycii, A.I.Aeaieaeiaei). I?aeneeaiiy ia?aeeniiai ieeneaiiy e?i?ae?a o ia?aioei? i?aeoeoieiai? caeice uo??a ye caaaeueiee iaoiaaiaoe/iee /eiiee aenia?eiaioaeueiiai aino?iai iaie?aaoeoo // Iaeanueeee iaaee/iee aeo?iae. -1998. -?6. -C.27-30. (o ni?ao. c A.I.Aeaieaeiaei, I.A.Neiiaoeai). I?eiaiaiea aiaeiaia iae?iiaioeaeia a eiiieaena ea/aiey o?iie/aneiai iaie?aaoeoa // Ee?i. o??o?a?y. -Iaoa?. ?? eiia?ano o??o?a?a Oe?a?ie. -Ee?a-Aeiiaoeuee, 1998. -N.117-118. (o ni?aaao. c ?.I.Eeaiaioue?aei, N.A.Oeeiia'ycii, A.I.Aeaieaeiaei). Oa?iaeioa?aiey ycaaiiie aieacie aeaaiaaeoeaoeia?noiie eeoee // Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??. -Oace aeii. ?? Oe?. iaoe. eiio. c i?aeia?iaeiith o/anoth. -A?iieoey, 1998. -N.182-183. (o ni?aaao. c A.I.Aeaieaeiaei, N.A.Oeeiia'ycii). Iaoioeceieiae/aneea iaoaieciu iae?iyiaeie?eiiuo ia?ooaiee i?e ino?ie aaaeiieiaeueiie iaoieiaee // Aeinyaiaiiy oa iaae??oai? ieoaiiy aano?iaioa?ieia??. -Iaoa?. iaoe. i?aoeue ?ani. iaoeiai-i?aeo. eiio. -Oa?e?a, 1998. -N.83. (o ni?aaao. c. A.I.Ia?eiaei). AIIOAOe?? Neiiaaoeue I.E. Aieea aiaeia?a iae?iiaioeae?a ia noai aaeaioaoe?eieo iaoai?ci?a i?e ia?eoii?o? (aenia?eiaioaeueia aeine?aeaeaiiy). - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.03.04. - iaoieia?/ia o?c?ieia?y. - Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie, Iaeana, 1999. Aeena?oaoe?th i?enay/aii aeine?aeaeaiith iaoiaaiaoe/ieo aniaeo?a aino?iai aenia?eiaioaeueiiai ia?eoii?oo, ye? noinothoueny aea/aiiy iae?iaoii?aeueieo ii?ooaiue ca oiia ia?aa?ao iaoieia?? oa ?ic?iaoe? ia oe?e i?aenoaa? iaoiaaiaoe/ii iaa?oioiaaii? oa?ai?? cacia/aiiai noaio oeyoii canoinoaaiiy i?aia?ao?a aiaeia?a iae?iiaioeae?a. Iieacaii ae?aci? aoaeoe i?e canoinoaaii? neioaoe/ieo aiaeia?a ii?i?aeieo iio?aeieo - aeaea?a?io, naiaeinoaoeio oa ?ioeo iaioeae?a, ui aaeeaathoueny ie?aii aai o eiia?iaoe?yo. Aoaeoeai?noue cacia/aieo iae?iiaioeae?a aoea ae?aciith uiaei i?eai?/aiiy i?ioean?a a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a, ii?iae?caoe?? ai?iiiaeueiiai aaeaino o e?ia? oa iie?ioaiiy aeaeeaaiino? aenia?eiaioaeueieo oaa?ei o ??ci? oa?i?ie (1-9 ae?a) i?ney a?aeoai?aiiy oe??? iaoieia??. Io?eiai? ?acoeueoaoe ? aenia?eiaioaeueiei iaa?oiooaaiiyi aeey ee?i?/ii? ai?iaaoe?? i?aia?ao?a, ye? aeine?aeaeoaaeeny. Eeth/ia? neiaa: ia?eoii?o, a?eueii?aaeeeaeueia ieeneaiiy e?i?ae?a, iae?iiaioeaee, ai?iiie. Nuiiaaoe I.E. Aeeyiea aiaeiaia iae?iiaioeaeia ia ninoiyiea aaeaioaoeeiiiuo iaoaieciia i?e ia?eoiieoa (yenia?eiaioaeueiia enneaaeiaaiea). - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.04 - iaoieiae/aneay oeceieiaey. - Iaeanneee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao IC Oe?aeiu, Iaeanna, 1999. Caueuathony 7 iao/iuo ?aaio, iinayuaiiuo enneaaeiaaieth aeeyiey iiauo neioaoe/aneeo aiaeiaia iae?iiaioeaeia ia eiiiainaoi?ii-i?eniiniaeoaeueiua ?aaeoeee e?un a oneiaeyo ino?iai yenia?eiaioaeueiiai ia?eoiieoa. A aeenna?oaoeee eco/athony oaeaea iaoiaaiaoe/aneea aniaeou ino?iai yenia?eiaioaeueiiai ia?eoiieoa, eanathueany enneaaeiaaiey iae?iaoii?aeueiuo ia?ooaiee a oneiaeyo aeaiiie iaoieiaee, e ?ac?aaioea ia yoii iniiaaiee iaoiaaiaoe/anee iainiiaaiiie oa?aiee iooai i?eiaiaiey i?aia?aoia aiaeiaia iae?iiaioeaeia. Iieacaiu au?aaeaiiua yooaeou i?e i?eiaiaiee neioaoe/aneeo aiaeiaia i?iecaiaeiuo iieieaeiuo iaioeaeia - aeaea?aeia, eaiaioaia, iao?ioeia e naiaeinoaoeia, eioi?ua i?eiaiyee eae naiinoiyoaeueii, oae e a eiiaeiaoeeyo. Auei onoaiiaeaii, /oi ino?ue yenia?eiaioaeueiue ia?eoiieo nii?iaiaeaeaaony ?aceei oneeaieai eioaineaiinoe naiaiaeii?aaeeeaeueiuo i?ioeannia e iaeiieaieai i?iaeoeoia ia?ieneaeaoeee a nuai?ioea e?iae. I?e yoii o e?un ioia/aaony oaiaoaiea ooieoeeiiaeueiie aeoeaiinoe aioeieneaeaioiie nenoaiu. Aa?iyoiaa anaai, ioia/aiiua i?eciaee - iaeiieaiea i?iaeoeoia ia?ieneaeaoeee e oaiaoaiea aeoeaiinoe aioeieneaeaioiie nenoaiu - yaeythony iaeieie ec iaoiaaiaoe/aneeo caaiueaa ino?iai aiieiiai yenia?eiaioaeueiiai ia?eoiieoa. Iieo/aiiua aeaiiua iieacaee au?aaeaiiue aioeieneaeaioiue yooaeo aeaea?aeia, eioi?ue aeeeeny a oa/aiea 9 nooie n iiiaioa aini?iecaaaeaiey yenia?eiaioaeueiiai ia?eoiieoa. Ioia/aiiue yooaeo au?aaeaeny a nieaeaiee iaeiieaiey i?iaeoeoia naiaiaeii?aaeeeaeueiiai ieeneaiey e aeoeaaoeee aioeieneaeaioiie nenoaiu. Ioia/aaony oaeaea iacia/eoaeueii au?aaeaiiia aioeieneaeaioiia aeaenoaea eaiaioaia e naiaeinoaoeia. Eiaeaeoi? i?ioaac iao?ioei oneeeaae yooaeoeaiinoue aioeieneaeaioiiai aeaenoaey aeaea?aeia. Yoe ?acoeueoaou iieacuaatho eeth/aaia cia/aiea eioaineoeeaoeee i?ioeannia naiaiaeii?aaeeeaeueiiai ieeneaiey e oaiaoaiey aioeieneaeaioiie nenoaiu a iaoiaaiaca ino?iai yenia?eiaioaeueiiai ia?eoiieoa. Iieacaii, /oi ii?iaeecaoeey aeoeaiinoe aioeieneaeaioiie nenoaiu iiae aeeyieai i?aia?aoia aiaeiaia iae?iiaioeaeia, ia?yaeo n o?aaeeoeeiiiuie iieacaiiuie iaoiaeaie ea/aiey, niinianoaoao eeeaeaeaoeee ainiaeeoaeueiiai i?ioeanna a a?thoiie iieinoe. Enneaaeiaaeenue oaeaea iieacaoaee eaoaeueiinoe aeeaioiuo a oneiaeyo i?eiaiaiey eae aaciaie oa?aiee i?e iiiiue aiieiena, oae e aaaaeaiey aiaeiaia iae?iiaioeaeia. Enneaaeiaaiey iieacaee, /oi ia 9-a nooee ea/aaiue eiiieaen aeaea?aeia n iao?ioeiii a 3.2 ?aca nieaeae eaoaeueiinoue yenia?eiaioaeueiuo aeeaioiuo, /oi i?aauoaei niioaaonoaothuea iieacaoaee a neo/aa oiio?aaeaiey aiieiena. A aeaeueiaeoai auyaeaiu nouanoaaiiua eciaiaiey nae?aoeee ai?iiiia aano?iyioa?iiaie?aaoe/aneie nenoaiu ii ia?a ?acaeoey e aeaeueiaeoaai i?ia?anne?iaaiey ino?iai aiieiiai yenia?eiaioaeueiiai ia?eoiieoa. Yoe eciaiaiey i?iyaeyeenue aeaea nieaeaiey eiioeaio?aoeee niiaoinoaoeia, aetheaaiia e einoeeia, a oaeaea oaaee/aiey eiioeaio?aoeee aano?eia. E?iia yoiai, oa/aiea ino?iai aiieiiai yenia?eiaioaeueiiai ia?eoiieoa nii?iaiaeaeaaony aeenaaeainii nae?aoi?iie aeoeaiinoe ai?iiiia aeiioeca?ii-iaaeii/a/ieeiaie ooieoeeiiaeueiie nenoaiu, a oaeaea iieieaeiuo ai?iiiia. Aeaiiua eciaiaiey yaeythony iaeaieaa au?aaeaiiuie ia 5-a nooee n iiiaioa aini?iecaaaeaiey iaoieiae/aneiai ninoiyiey o yenia?eiaioaeueiuo aeeaioiuo e caeeth/athony i?aeiouanoaaiii a nouanoaaiiii oaaee/aiee iieacaoaeae nae?aoi?iie aeoeaiinoe AEOA e ei?oeeinoa?iia. Neaaeoao oaeaea ioiaoeoue, /oi iaeiia?aiaiii n yoei i?ienoiaeeo nieaeaiea aeoeaiinoe yiaeiaaiiie iieieaeiie nenoaiu. A oneiaeyo iiaeaeueiie iaoieiaee aeaea?aei ii?iaeeciaae aeenaaeain nae?aoi?iie aeoeaiinoe aano?iyioa?iiaie?aaoe/aneie e aeiioeca?ii-iaaeii/a/ieeiaie ai?iiiaeueiuo nenoai. Aiaeiae/iia, ii iaiaa au?aaeaiiia aeaenoaea ieacuaaee eaiaioai e naiaeinoaoei. Iniiaiuie iaoaieciaie ea/aaiiai yooaeoa ioia/aiiuo i?aia?aoia yaeythony ii?iaeecaoeey aeenaaeaina ai?iiiaeueiuo nenoai e oaaee/aiea aeoeaiinoe iieieaeiie nenoaiu, /oi ieacuaaao no?ann-i?ioaeoi?iia aeaenoaea ia i?aaieci yenia?eiaioaeueiuo aeeaioiuo a iiaeaeueiuo oneiaeyo. Ii anae aeaeeiinoe, iniiaiuie iaoaieciaie caueoiiai aeaenoaey aeaea?aeia e aai eiiaeiaoeee n eiaeaeoi?ii i?ioaac iao?ioeiii yaeythony ii?iaeecaoeey iieacaoaeae ooieoeeiiaeueiie aeoeaiinoe aeiioeca?ii-iaaeii/a/ieeiaie e iieieaeiie nenoai, aneaaenoaea /aai nieaeaaony eioaineaiinoue aeano?oeoeaiuo i?ioeannia, ii?iaeecaoeeae o?iaiy yieaoaeeiia e yiaei?oeiia a e?iae. Ioia/aiiia yaeyaony eiiieaeniie i?eniiniaeoaeueii-aaeaioeaiie ?aaeoeeae i?aaiecia, eiaao ianiiiaiioth aioeno?anni?ioth iai?aaeaiiinoue e iiauoaao ?acenoaioiinoue i?aaiecia. Ioia/aiiua i?ioaeoeaiua naienoaa ea/aaiiai eiiieaena, aeeth/athuaai a naay aeaea?aei e iao?ioei, ?aaii eae e ?acaeaeueiiai aaaaeaiey aeaea?aeia, eaiaioaia e naiaeinoaoeia, yaeythony yenia?eiaioaeueiui iainiiaaieai eo eeeie/aneiai i?eiaiaiey a ea/anoaa ninoaaiiai eiiiiiaioa a eiiieaeniii iaoiaaiaoe/aneii ea/aiee aieueiuo n ?aceeoui aiieiui ia?eoiieoii a iineaiia?aoeeiiiii ia?eiaea. Eeth/aaua neiaa: ia?eoiieo, naiaiaeii?aaeeeaeueiia ieeneaiea eeieaeia, iae?iiaioeaeu, ai?iiiu. Synovets N.L. The influence of neuropeptides analogues on the expression of the adaptational mechanisms in case of peritonitis (experimental investigation). - Manuscript. Thesis for a scientific degree of candidate of medical sciences in speciality 14.03.04 - pathological physiology. - Odessa State Medical University Ministry of Health Care of Ukraine, Odessa, 1999. The pathogenetical aspects of the acute experimental peritonitis, especially neurohumoral disturbances, are studied in the thesis from the point of view of pathogenetical therapy making via neuropeptides analogues using. The expressed effects of synthetic opioids - dalargin, sandostatin etc. - alone and in combination are shown. Neuropeptides efficiently suppressed lipid peroxidation, normalized blood hormonal level as well as enlarged life duration of the experimental animals in different time periods (1-9 days) from the moment of the pathological state modeling. The obtained data are the experimental background the used peptides for clinical trial. Key words: peritonitis, lipid peroxidation, neuropeptides, hormones. PAGE PAGE 16

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