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OA?EIANUeEEE AeA?AEAAIEE OIIAA?NEOAO

AeCTHAA AIEOI?Iss IEEIEA?AIA

OAeE 57.017.67:577.352.38

AIEIAI INIAEEAINOI AIEEAO IOAII? IA

NO?OEOO?II-OOIEOeIIIAEUeIEE NOAI IIOIOIIAe?IE

I IA?AEENIA IEENEAIIss EIIIAeIA NA?Oess UO?IA

03.00.04 – aiioiiiy

AAOI?AOA?AO

aeena?oaoei? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa aiieiai/ieo iaoe

Oa?eia – 1998

?iaioa aeeiiaia a iaoeiai-aeineiaeiiio iinoeoooi aiieiai? Oa?eianueeiai
aea?aeaaiiai oiiaa?neoaoo Iiiinoa?noaa inaioe Oe?a?ie

Iaoeiaee ea?iaiee: aeieoi? aiieiai/ieo iaoe, i?ioani?

Eaiaoei Aieoi? Aaneeueiae/, aee?aeoi? iaoeiai-

aeineiaeiiai iinoeoooo aiieiai? Oa?eianueeiai

aea?aeaaiiai oiiaa?neoaoo Iiiinoa?noaa inaioe Oe?a?ie

Ioioeieii iiiiaioe: aeieoi? aiieiai/ieo iaoe, i?ioani?

Iao?aiei Ieaenaiae? TH?ieiae/, i?iaiaeiee iaoeiaee

niia?iaioiee aiaeaeieo aenia?eiaioaeueii? e?iiiaaee-

oeeie iinoeoooo i?iaeai e?iiaiieiai? i e?iiiaaeeoeeie

IAI Oe?a?ie

aeieoi? aiieiai/ieo iaoe, i?ioani?

AEaaoiia Aaiaaeie Oaaei?iae/, caaiaeoaa/ eaoaae?ith

iaaee/ii? aiieiai?, ia?aceoieiai? oa aaiaoeee

Oa?eianueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo

Iiiinoa?noaa ioi?iie caei?ia’y Oe?a?ie

I?iaiaeia onoaiiaa: Iinoeooo aa?iioieiai? (eaai?aoi?iy iieaeoey?ii?

aaiaoeee) AII Oe?a?ie, i.Ee?a.

Caoeno aiaeaoaeaoueny “16” a?oaeiy 1998 ?. i 1515 aiaeeii

ia caniaeaiii niaoeiaeiciaaii? a/aii? ?aaee E 64.051.17 i?e
Oa?eianueeiio aea?aeaaiiio oiiaa?neoaoi Iiiinoa?noaa inaioe Oe?a?ie ca
aae?anith:

310077, i. Oa?eia, i. Naiaiaee, 4, aoae. III-15.

C aeena?oaoei?th iiaeia iciaeiieoeny o Oeaio?aeueiie iaoeiaie
aiaeiioaoei

Oa?eianueeiai aea?aeaaiiai oiiaa?neoaoo Iiiinoa?noaa inaioe Oe?a?ie ca
aae?anith: 310077, i. Oa?eia, i. Naiaiaee, 4.

Aaoi?aoa?ao ?icineaiee “13” eenoiiaaea 1998 ?.

A/aiee nae?aoa?

niaoeiaeiciaaii? a/aii? ?aaee

eaiaeeaeao aiieiai/ieo iaoe,

noa?oee iaoeiaee niia?iaioiee
Iaaeaeei A.I. 1

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue oaie. Na?oeaai-noaeeiii caoai?thaaiiy ciaoiaeyoueny ia
iaeiiio c ia?oeo iinoeue a no?oeoo?i caoai?thaaiiy oa nia?oiinoi
iana-eaiiy a aieueoinoi e?a?i naioo [Eii ?.I., 1992]. Oeae oaeo ii?yae c
ii-oe?aiiyi iia?aoeieieo ao?o/aiue, yei iio?aaothoue oei/aniaiai
i?eieiaiiy e?iaiiaiao a i?aaiao, a oaeiae ona aieueo /anoa aeei?enoaiiy
o?ain-ieaioaoei? i?aaiia, ?iaeyoue ?icoiiiiy iieaeoey?ieo iaoaiiciia
ioaii/iiai iioeiaeaeaiiy i?aaiia iaeii?th c iaeaeooaeueiioeo i?iaeai
no-/anii? iaoee. Aeooaeueiinoue i?iaeaie oaeiae coiiaeth?oueny
iaiaoiaeiinoth ?ic?iaee iiaeo caniaia caiiaiaaiiy ioaii/iiai
iioeiaeaeaiiy oeaiei.

A eioa?aoo?i ? aeinoaoiuei aaeeea eieueeinoue aeaieo aiaeiinii aieeao
ioaii? ia no?oeoo?ii-ooieoeiiiaeueiee noai iiiea?aeo [Eaiaoei A.A. e
ae?., 1986; Aeeaiei I.A., 1989; Kleber A.G., 1990; Downey J.M., 1990;
Coudray C. et al., 1995; Tani M. et al., 1997]. Iacaaaeath/e ia oea,
iaoaiicie ioaii/iiai iioeiaeaeaiiy, i?e/eiii-ianeiaeiee ca’ycie iiae
aa-aaoueia iaoiaaiaoe/ieie oaeoi?aie oa aieiai iniaeeainoi ioaii/iiai
iioeiaeaeaiiy i?aaiia i oeaiei caeeoathoueny ia nueiaiaeiioiie aeaiue
iaaein-oaoiuei aea/aieie.

Iaeio c aieiaieo ?ieae o iaoaiicii ioaii/iiai oa ?aia?oocieiiai
iioeiaeaeaiiy oeaiei aieueoinoue aeineiaeieeia i?eaeieythoue
aieueii?aaeeeaeue-iiio ia?aeeniiio ieeneaiith eiiiaeia (IIE), oi/a aeaii
aiaeiinii iioai-neaiinoi IIE i noaio oa?iaioaoeaii? aioeieneaeaioii?
nenoaie na?oey i?e ioaii? aeinoaoiuei noia?a/ii. Cie?aia, iniothoue
aeaii, ui naiae/aoue, ye i?i iineeaio aaia?aoeith aieueieo
?aaeeeaeia [Suri R.K. et al., 1996] i cieaeaiiy aeoeaiinoi
aioeieneaeaioieo oa?iaioia [Simmons T.W. et al., 1989; Porreca E.
et al., 1994] i?e ioaii?, oae i i?i aiaenooiinoue ciii
ieenethaaeueiiai oa aioeieneaeaioiiai noaoono na?oey [Ji L.L. et
al., 1994; Coudray C. et al., 1995] i?e oeueiio aeaei iaoi-eiai?.

A eioa?aoo?i iaia? oaeiae /ioei? aiaeiiaiaei ia ieoaiiy i?i ia?oi-?yaeia
cia/aiiy iioeiaeaeaiiy ?icieo noaeeioeiieo no?oeoo? a ioaii/iiio
ii?ooaiii ooieoeie eeioei i oeaiei [Hoffstein S. et al., 1975; Nayler
W.G., 1982; Aeaio?ia A.A. e ae?., 1985]. Aaeeeo oaaao a oeueiio ieaii
i?eaa?oathoue aei naaa iioioiiae?i? [Schmiedl A. et al., 1990;
Veitch K. et al., 1992; Miller T.W. et al., 1995], ineieueee aiie ?
iniiaiei niiaeeaa/ai eenith oa iaeii/anii aieiaiei aeaea?aeii aia?ai? a
eeioeii.

Aeoiaey/e ci neacaiiai aeua oa i?eeiath/e aei oaaae ?aiio i?iaaaea-

2

ii aeineiaeaeaiiy a iaoie oa iioeo eaai?aoi?iyo [Eaiaoei A.A. e ae?.,
1989; Stio M. et al., 1994] aiaeiinii aieeao noa?iiiy oaa?ei ia
?iaaiue aia?aaoe/iiai iaiiio oa eiiiia?aeeniee iioaioeiae iiiea?aeo,
iai oyaeyeiny aaaeeeaei i?iaaaeaiiy ii?iaiyeueiiai aiaeico ciii
iioai-neaiinoi IIE, eiai oa?iaioaoeaii? ?aaoeyoei? oa
no?oeoo?-ii-ooieoeiiiaeueiiai noaio iioioiiae?ie iiiea?aeo iieiaeeo i
noa?eo uo?ia i?e ioaii?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?-oaoeieia
?iaioa aeeiiaia caiaeii c ieaiaie iaoeiai-aeineiaeieo ?iaio: “Onoaiiaeoe
?ieue oa?iaioaoeaii? ?aaoeyoei? ia?aeeniiai ieeneaiiy eiiiaeia a
iaoaiiciao aieiai? ia?aaoaeiae oa ioaii/iiai iioeiaeaeaiiy iaia?ai
iiiea?aeo oa iioeo oeaiei” (N aea?ae. ?a?no?aoei? 0187.0009268, Oa?eia:
1990), “Aea/aiiy aieiaeo iniaeeainoae ioaii/iiai iioeiaeaeaiiy oeaiei i
?ic?iaea e?eoa?i?a iiooeo iiaeo ea?aeii- i aa?ii?ioaeoi?ia” (N aea?ae.
?a?no?aoei? 01.9.10036893, Oa?eia: 1993), “Aeineiaeaeaiiy
eiii-ia?aeeniiai iaoaiicio ioaii/iiai iioeiaeaeaiiy aiiiaia?ai i
?ic?iaea iiaeo iaia?aiii?ioaeoi?ia” (N aea?ae. ?a?no?aoei? UA 01008697P,
Oa?eia: 1996).

Iaoa i caaea/i aeineiaeaeaiiy. Iaoith ?iaioe aoei c’ynoaaiiy aieiaeo
caeiiiii?iinoae ciiie no?oeoo?ii-ooieoeiiiaeueiiai noaio iioioiiae?ie,
iioaineaiinoi IIE i eiai ?aaoeyoei? i?e oioaeueiie ioaii? oa ioaii?
-?aia?ooci? na?oey uo?ia.

Aeoiaey/e c iaoe, aoee aecia/aii ianooiii caaea/i:

1. Aea/eoe aieiai iniaeeainoi aieeao oioaeueii? oa ia?a?aaii? ioaii?
na?oey uo?ia ia iioaineaiinoue IIE.

2. Aeineiaeeoe aieiai iniaeeainoi aieeao ioaii? ia noai oa?iaioaoeaii?
aioeieneaeaioii? nenoaie iiiea?aeo uo?ia.

3. Aea/eoe aieiai iniaeeainoi aieeao oioaeueii? ioaii? ia
no?oeoo?-ii-ooieoeiiiaeueiee noai iioioiiae?ie na?oey.

4. Ioeiieoe i?ioeioaii/io aeith ?yaeo i?e?iaeieo iaoaaieioia c iaoith
?ic-?iaee caniao caoenoo iiiea?aeo aiae ioaii/iiai iioeiaeaeaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoaoia. Aia?oa aeineiaeaeaii aieiai
ciiie iioaineaiinoi IIE oa eiai ?aaoeyoei?, iioeiaeaeaiiy na?eieaie oa
ii?ooaiiy no?oeoo?ii-ooieoeiiiaeueiiai noaio iioioiiae?ie o aeeiaiioei
ioaii/iiai iioeiaeaeaiiy iiiea?aeo uo?ia i anoaiiaeaii, ui aeoeaaoeiy
IIE aiaeaoaa?oueny ia?aae ii?ooaiiyi oeieinoiinoi na?eieaie oa no?oeoo?e
i ooieoei? iioioiiae?ie i ? neeaaeiaith /anoeiith iaoaiicio
iioeiaeaeaiiy iaia?ai ea?aeiiiiioeeoia. Aeyaeaii, ui iaeaieueoo
/ooeeainoue aei

3

ioaii/iiai iioeiaeaeaiiy aeyaey? iiiea?ae noa?eo uo?ia.

Ia iiaenoaai aeineiaeaeaiiy i?ioeioaii/ieo aeanoeainoae ?yaeo
i?e?iae-ieo iaoaaieioia ?ic?iaeaii na?aaeiaeua aeey caiiaiaaiiy
ioaii/iiai iioeiaeaeaiiy oeaiei iiae /an o?ainieaioaoei? i?aaiia, yea
nooo?ai ciai-oo? iioeiaeaeaiiy iaia?ai ea?aeiiiiioeeoia, iaeiie/aiiy
i?iaeoeoia IIE oa iieiioo? aiaeiiaeaiiy nei?i/oaaeueii? aeoeaiinoi
na?oey iiney ioaii? – ?aia?ooci? (A.n. SU 1632427 A1, A 61 E 9/08).

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoaoia. ?acoeueoaoe i?iaaaeaieo
aeineiaeaeaiue aeicaieythoue aeeaaea c?icoiioe i?e/eiii-ianeiaeiee
ca’ycie iiae ?icieie iaoiaaiaoe/ieie oaeoi?aie, yei i?ecaiaeyoue aei
iacai?io-iueiai iioeiaeaeaiiy na?oey i?e ioaii?, i iioe?eoe inioth/i
oyaeaiiy i?i iaoaiicie ?aaeoei? eeioei iiiea?aeo ia ioaii/iee aieea.

Ia iniiai iaea?aeaieo aeaieo aiaeiinii i?ioeioaii/ieo aeanoeainoae
i?e?iaeieo iaoaaieioia ?ic?iaeaii na?aaeiaeua aeey iiia?aaeaeaiiy
ioaii/iiai iioeiaeaeaiiy i?aaiia, yea iiaea aooe aeei?enoiaaiei a
aen-ia?eiaioaeueiie i eeiii/iie ea?aeiieiai? (A.n. SU 1632427 A1, A 61 E
9/08).

Iniaenoee aianie caeiaoaa/a. I?e aeeiiaiii aeena?oaoeieii? ?iaioe aaoi?
iniaenoi aea?aa oa e?eoe/ii ioeiiea i?enooiio eioa?aoo?o ca oa-iith
aeineiaeaeaiiy. Iiae /an aeeiiaiiy aenia?eiaioaeueii? /anoeie ?iaioe
aeineiaeaeaiiy noiniaii iioaineaiinoi i?ioeania IIE oa
no?oeoo?-ii-ooieoeiiiaeueiiai noaio iioioiiae?ie /anoeiai aoee
i?iaaaeaii niieueii ci niia?iaioieeaie IAeI aiieiai? OAeO e.a.i.
Iieio/aiei TH.A. oa e.a.i. Oaeiaieiaith I.A., ui ciaeoei aiaeia?aaeaiiy
o niieueieo ioaeieaoeiyo. Aeianaii ia caoeno iieiaeaiiy i ?acoeueoaoe
iaea?aeaii aee-na?oaioii naiinoieii. Aeena?oaioii ?acii c iaoeiaei
ea?iaieeii i?iaa-aeaii aiaeic iaea?aeaieo ?acoeueoaoia i c?iaeaii
aeniiaee ii ?iaioi.

Ai?iaaoeiy ?acoeueoaoia aeena?oaoei?. Iniiaii iieiaeaiiy ?iaioe
aei-iiaiaeaeeny ia II iaoeiiiaeueiiio eiia?ani aa?iioieiaia i aa?iao?ia
Oe-?a?ie (i.Ee?a, 1994 ?.), ia iaoeiai-i?aeoe/iie eiioa?aioei? “Iaoeiai
aeinyaiaiiy i i?iaeaie ae?iaieoeoaa eiea?nueeeo caniaia” (i.Oa?eia,
1995 ?.), ia eiioa?aioei? iieiaeeo o/aieo aiieiai/iiai oaeoeueoaoo i
IAeI aiieiai? (i.Oa?eia, 1997 ?.), ia III iiaeia?iaeiiio niiiicioii
“Aiieiai/ii iaoaiicie noa?iiiy” (i.Oa?eia, 1998 ?.).

Ioaeieaoei?. Iniiaii iieiaeaiiy ?iaioe iioaeieiaaii o 17 iaoeiaeo
?iaioao, na?aae yeeo 4 noaooi oa 1 aaoi?nueea naiaeioeoai.

No?oeoo?a oa ianya aeena?oaoei?. Aeena?oaoeiy neeaaea?oueny ic anooio,
iaeyaeo eioa?aoo?e c i?iaeaie, 3 ?icaeieia, ui aiaeia?aaeothoue
?acoeueoaoe

4

aeanieo aeineiaeaeaiue, aeniiaeia oa nieneo aeei?enoaieo aeaea?ae, yeee
iinoeoue 239 aeaea?ae. ?iaioo aeeeaaeaii ia 128 noi?iieao iaoeiiieno,
iethno?iaaii 11 ?enoieaie i 21 oaaeeoeath.

IAOA?IAEE I IAOIAeE AeINEIAeAEAIIss

O aeineiaeao aeei?enoiaoaaee uo?ia eiii? Ainoa? 1-, 3-, 12- i
24-iiny/iiai aieo.

Ioaii/ia iioeiaeaeaiiy eeioei na?oey aea/aee ia aeaio iiaeaeyo:
oi-oaeueii? ioaii? i ia?a?aaii? ioaii? icieueiaaiiai na?oey,
ia?oociaaiiai na?aaeiaeuai Oaiena aac aetheice ca noaiith “19 oaeeei
ioaii? – 1 oae-eeia ?aia?ooci?”. I?e aea/aiii i?ioeioaii/ieo
aeanoeainoae i?e?iaeieo iaoaaieioia aeineiaeaeoaaio ?a/iaeio
aeiaeaaaee o aecia/aiie eiioeaio?aoei? a na?aaeiaeua ia?ooci? na?oey.

Aiaeic iioeiaeaeaiiy iioioiiae?ie na?oey i?iaiaeeee a nenoaii
aiiiaa-iaoo oeaieie. Oaeaeeinoue aeeoaiiy i ieenethaaeueiiai
oinoi?eethaaiiy aec-ia/aee iiey?ia?aoi/iei iaoiaeii [Eiiae?aoaaa I.I. e
ae?., 1973]. Ii e?eaeo niiaeeaaiiy eenith ?ic?aoiaoaaee oaeaeeinoue
aeeoaiiy a iaoa-aiei/ieo noaiao 3 i 4 ca *ainii (V3 i V4), a
?ic’?aeiaiiio noaii (V3?) i aeeoaeueiee eiio?ieue (AeE). AOOacio
aeoeaiinoue aiiiaaiaoia na?-oey aeii?thaaee iioaioeiiiao?e/iei iaoiaeii
[Aieaeu?aa A.A., 1977]. Aeni-eiaiieiooaeia iaaooaiiy iioioiiae?ie
?a?no?oaaee ii ciiiaiith iioe/ii? uieueiinoi i?e aeiaaeeii oaeei 610 ii
[Oaeiaeeiaa A.A., 1994].

Iioaineaiinoue ia?aeeniiai ieeneaiiy eiiiaeia ioeiithaaee ii
iioai-neaiinoi oaiiethiiianoeaioei? (OEI) i oaeaeeinoi iaeiie/aiiy
iaeiiiaiai aeiaeueaeaaiaeo (IAeA) ye iienaii a ?iaioi [Eaiaoei A.A. e
ae?., 1987]. Aiino aiae?iia?aeenia eiiiaeia o aiiiaaiaoao na?oey
aecia/aee ca iaoi-aeii Ohkawa et al. c aeayeeie iiaeeoieaoeiyie
[Eaiaoei A.A. e ae?., 1986].

Aeooaoiiiia?ieneaeacio aeoeaiinoue aeii?thaaee niaeo?ioioiiao?e/ii a
ni?yaeaiie aeooaoiii?aaeoeoaciie ?aaeoei? ca iaoiaeii Paglia et al. c
aeayeeie iiaeeoieaoeiyie [Eaiaoei A.A. e ae?., 1987].
Aeooaoiii-S-o?ain-oa?acio aeoeaiinoue aeii?thaaee niaeo?ioioiiao?e/ii
i?e 340 ii [Jones M. et al., 1980] c 1-oei?-2,4-aeiiio?iaaicieii a
yeinoi noano?aoo. Aeooaoiii?aaeoeoacio aeoeaiinoue aecia/aee
oeoi?eiao?e/ii ca ciaioai-iyi ?iaith NADPH [Aa?aneiia A.I. e ae?.,
1976]. Eaeoaoaeaaiae?iaaiacio aeoeaiinoue a ia?oocaoao ioaiiciaaieo i
eiio?ieueieo na?aeaoeue aeii?thaa-ee ca iaoiaeii [Eaaiia E.E. e ae?.,
1974], ?a?no?oth/e oeoi?eiao?e/ii

5

aiaeiiaeaiiy NAD+. Aetheici-6-oinoaoaeaaiae?iaaiacio aeoeaiinoue
aeii?th-aaee oeoi?eiao?e/ii ii oaeaeeinoi aiaeiiaeaiiy NADP+ [Baquer
N.Z. et al., 1967]. NADP+-caeaaeio iaeaoaeaaiae?iaaiacio aeoeaiinoue
aecia/aee oeoi?eiao?e/ii ii oaeaeeinoi aiaeiiaeaiiy NADP+ [Onaoaiei I.N.
e ae?., 1974]. NADP+-caeaaeio icioeeo?aoaeaaiae?iaaiacio aeoeaiinoue
aecia/aee oeoi?eiao?e/ii ii oaeaeeinoi aiaeiiaeaiiy NADP+ [Bauman D.E.
et al., 1970]. Noia?ieneaeaeeniooacio (NIAe) aeoeaiinoue aecia/aee
niaeo?ioioi-iao?e/ii ca iaoiaeii Fridovich o iiaeeoieaoei? Eaieiia
[Eaieei A.C. e ae?., 1976]. Eaoaeacio aeoeaiinoue aecia/aee
niaeo?ioioiiao?e/ii i?e 240 ii [Marklund S. et al., 1981]. ?iaaiue
iai?aaii/iiai oinoaoo (Oi) aecia/aee ye iienaii [?uaaeue/aiei A.E. e
ae?., 1988].

Aeno?aaoaaiiy eiiiaeia ic iaia?ai iiiea?aeo i?iaiaeeee ye iienaii [Folch
J. et al., 1957]. Aiino caaaeueieo eiiiaeia aecia/aee ca
iaoi-aeii [March J.B. et al., 1966]. Aioeieenethaaeueio aeoeaiinoue
aeno?aai-aaieo eiiiaeia aecia/aee ye iienaii a ?iaioi [Eeaaaiia A.E. e
ae?., 1988].

Aiino aieeo a c?aceao aecia/aee ca iaoiaeii Eio?i i niiaaao. o
iiaeeoieaoei? Iieea?a [Miller G.L., 1959].

Noaoenoe/io ia?iaeo ?acoeueoaoia i?iaiaeeee ca iaoiaeii
Nouethaeai-oa-Oioa?a [Oa?aioueaa I.A. e ae?., 1977].

INIIAII ?ACOEUeOAOE AeINEIAeAEAIIss

Aieea ioaii? na?oey ia iioaineaiinoue ia?aeeniiai ieeneaiiy ei-iiaeia i
eiai oa?iaioaoeaio ?aaoeyoeith o uo?ia ?iciiai aieo. Aeineiaeaeaiiy
iioaineaiinoi IIE, yeo oa?aeoa?ecoaaee ii iaeiie/aiith IAeA i
iioaineaiinoi oaiiethiiianoeaioei?, a aiiiaaiaoao na?oey uo?ia ?iciiai
aieo iieacaei, ui a eiio?iei niinoa?iaaeinue inoioia cieaeaiiy c
aieii iioaineaiinoi anei?aao-iiaeoeiaaiiai IIE. Oei ?acoeueoaoe
oc-aiaeaeothoueny c ?aiio iaea?aeaieie a iaoie eaai?aoi?i? aeaieie
[Eaiaoei A.A. e ae?., 1987]. Aeeiaiiea oaeaeeinoi iaeiie/aiiy IAeA aoea
yeinii noiaeith c aeeiaiieith ciiie iioaineaiinoi oaiiethiiianoeaioei?.

Iiney 3 aiaeei ia?a?aaii? ioaii? iioaineaiinoue anei?aao-iiaeoeiaa-iiai
IIE ?icei caieueooaaeany aiaeiinii eiio?ieth: a 1,4 – 1,5 ?ace – o
1-iiny/ieo i aieueo iiae o 5 ?acia – o 12- i 24-iiny/ieo uo?ia
(oaae. 1). Noiaei aieiai iniaeeainoi aieeao ioaii? ia iioaineaiinoue IIE
aoee iieacaii i aeey ia/iiee [Ieeeo/aiei TH.A. e ae?., 1997].

6

Oaaeeoey 1 Iaeiie/aiiy IAeA i iioaineaiinoue oaiiethiiianoeaioei? i?e

anei?aao-iiaeoeiaaiiio IIE o aiiiaaiaoao na?oey uo?ia ?iciiai aieo

a eiio?iei i iiney 3 aiaeei ia?a?aaii? ioaii? (n = 5 – 7)

————————————————————————
—————————–Aa?iaioe :
Aie, iin

aeineiaeo
:———————————————————————–
———-

: 1 : 12 :
24

————————————————————————
—————————–

Iaeiie/aiiy IAeA, iiieue IAeA/ia aieeo ca 10 oa iieoaaoei?

Eiio?ieue 7,7 1,1 0,8 0,5
1,4 0,7

Ioaiiy 11,8 1,4 (a) 6,2 2,3 (a) 8,3
2,1 (a)

Iioaineaiinoue oaiiethiiianoeaioei?, oen. iii./ia aieeo

ca 10 oa iieoaaoei?

Eiio?ieue 10,0 1,6 1,7 0,6
2,2 0,8

Ioaiiy 14,4 0,9 (a) 8,7 2,4 (a) 10,0
2,5 (a) I?eiioea: a – ?

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