I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Oa?e?anueeee iaoeiai-aeine?aeiee ?inoeooo i?e?ia?ieia??

oa ?ioiieia?? ?i. ?.?. Ia/i?eiaa

I?EIEUeNUeEA IEAIA ?AAI?AIA

OAeE 616.34-008.87-07-08:616-093/-098

OAeINEIIAEAIIss IAOIAeE*IEO I?AeOIAe?A UIAeI IOe?IEE

I?E?IA?IOeAIICO EEOA*IEEO OA EIAI EI?AEOe??

03.00.07-i?e?ia?ieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Ee?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe
?i. I.E.Ooieea I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie.

Iaoeia? ea??aieee:

Aeieoi? iaaee/ieo iaoe, i?ioani? Ciaiainueeee Aieiaeeie? Ieaen?eiae/

Aeieoi? iaaee/ieo iaoe, i?ioani? A?eueei ?aai Iao?iae/, caa?aeoaa/
eaoaae?ith i?e?ia?ieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe ?i. I.E.Ooieea.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Aaae/ ?aaai
Ieoaeeiae/, caa?aeoaa/ eaai?aoi???th e?aiaeueieo ?ioaeoe?e Oa?e?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo i?e?ia?ieia?? oa ?ioiieia?? ?i.
?.?.Ia/i?eiaa.

aeieoi? iaaee/ieo iaoe, aeioeaio AEo?eei Ieaenaiae? Aiaoie?eiae/,
ea??aiee a?aeae?eo i?e?ia?ieia?? ooaa?eoeueico oa ianiaoeeo?/ieo
caoai?thaaiue eaaaiue ?inoeoooo ooec?ao??? ? ioeueiiiieia?? ?i.
O.A.ssiianueeiai AII Oe?a?ie.

I?ia?aeia onoaiiaa: Iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? ?
?ioaeoe?eieo oai?ia ?i. E.A.A?iiaoaanueeiai IIC Oe?a?ie, i. Ee?a.

Caoeno a?aeaoaeaoueny “08” aeiaoiy 1999 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? A/aii? ?aaee Ae. 64.618.01. i?e Oa?e?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? i?e?ia?ieia?? oa ?ioiieia?? ?i.
?.?.Ia/i?eiaa, (310057, i. Oa?e?a, aoe. Iooe?inueea, 14).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo i?e?ia?ieia?? oa ?ioiieia?? ?i.
?.?.Ia/i?eiaa (i. Oa?e?a, aoe. Iooe?inueea, 14)

Aaoi?aoa?ao ?ic?neaiee “ 22” eeiiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? A/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe
?.TH. Eo/ia

caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie.

O i?ioean? aaiethoe??, aiane?aeie a?aeai?o i?ae i?aai?ciii ethaeeie ?
ioi/oth/eo eiai a?aeiia?aeieie aeaeaie i?e?ii?aai?ci?a, aeieeee
neia?ioe/i? aca?iia?aeiineie, caaaeyee yeei i?aai?ci ethaeeie ?
ianaeyth/? eiai i?e?ii?aai?cie noaee aeaiia o?nii c’?aeiaieie i?ae
niaith a?ieia?/ieie nenoaiaie. Canaeaiiy i?aai?cio ethaeeie
i?e?ii?aai?ciaie ? iaeiei c aeae?a aca?iiae?? aeeaeo ?noio a i?e?iae?,
yeee cae?enith?oueny ia ??ai? o?ei- ? iioiaaiaco oacy?ia (A.A.Ai?iaueaa
o ni?aaao., 1996 ).

I?aai?ci ethaeeie ? eiai ii?iaeueia i?e?ioei?a ? ?aeeiei aca?iica’ycaiei
? aca?iicaeaaeiei i?e?iaeiei eiiieaenii, noai yeiai o cia/i?e i???
aecia/a? noai caei?ia’y ethaeeie. I?e ae?? ??cieo iani?eyoeeaeo oaeoi??a
ia i?aai?ci ethaeeie aai eiai ii?iaeueio i?e?ioei?o a?aeaoaathoueny
ci?ie, ye aioo??oiueiai na?aaeiaeua i?aai?cio, oae ? noaio eiai
ii?iaeueii? i?e?ioei?e, ?, a ia?oo /a?ao, i?e?ioei?e eeoa/ieeo
(N.A.*aueia o ni?aaao., 1997)

I?e aeenaaeoa??ic? eeoa/ieeo ii?yae c? ci?iaie ye?nii-e?euee?nieo
iieaciee?a i?e?ioei?e eeoa/ieeo a?aeaoaathoueny ? ci?ie ?? ooieoe?e. I?e
oeueiio ii?ooothoueny aioaaii?noe/ia, o?aaia, a?oai?iineioacoth/a,
?ioiiaaiia, aeaoieneeaoe?eia oa ?io? ooieoe?? ii?iaeueii? i?e?ioei?e
eeoa/ieeo, ui iani?eyoeeai aieeaa? ia noai caei?ia’y ethaeeie
(A.A.Oaiaea?ia o ni?aaao., 1997).

Oiio aecia/aiith aeenaaeoa??ico eeoa/ieeo caaaeaee i?eae?eyeinue ?
i?eae?ey?oueny nueiaiaei? aaeeea cia/aiiy. ?acii c oei ne?ae a?aei?oeoe,
ui ? ia nueiaiaei? i?iaeaia aeenaaeoa??ico eeoa/ieeo ? i?iaeaiaoe/iith,
a aaaaoueio ieoaiiyo ia ae??oaiith, ye o ieai? i?e?ia?ieia?/iiai
aecia/aiiy, oae ? a ieai? aoaeoeaii? ei?aeoe??. Oae, aei oaia??oiueiai
/ano i?e?ia?ieia?/ia aecia/aiiy aeenaaeoa??ico eeoa/ieeo ethaeeie o
iaoiaee/i?e ieiuei? ? neeaaeiei, o?oaei?ieei ? ia caaaeaee aeineiiaeei.
?nioth/? iaoiaee aecia/aiiy aeenaaeoa??ico eeoa/ieeo iio?aaothoue
aeniei? eaae?o?eaoe?? e?ea?y – aaeoa??ieiaa, aaeeei? cao?aoe /ano,
??cieo iiaeeaieo na?aaeiaeu ? oi?iiy ioe?iee io?eiaieo ?acoeueoao?a, ui
ia a?aeiia?aea? no/aniei aeiiaai (A.I.Aiiaea?aiei o ni?aaao. 1998;
E.A.Aaaeaiia, 1997 ).

Ia caaaeaee aoaeoeaiith ? ? ei?aeoe?y aeenaaeoa??ico eeoa/ieeo ca
aeiiiiiaith ?nioth/eo i?aia?ao?a – aoa?ioee?a, ye? aeei?enoiaothoueny
aeey a?aeiiaeaiiy ii?ooaiue ii?iaeueii? i?e?ioei?e eeoa/ieeo aai
ni?eythoue ?? ii?iae?caoe??. Iaei??th c i?e/ei oeueiai ? iaea
aoaeoeai?noue aoa?ioe/ieo i?aia?ao?a ?c-ca iaaeniei? aeeoo?caeaoiino?
e?io?e?ciaaieo ee?oei i?e?ii?aai?cia – aoa?ioeea a aeaieo i?aia?aoao,
iaa?aeiia?aeiino? ?aaeueii aeeoo?caeaoieo ee?oei a ieo ?ic?aooieiaiio,
cieaeaiiy ?o eieii?caoe?eieo iiaeeeainoae, ui o noeoiiino? ? ciaioo?
i?iaeeaeaiiy ee?oei aoa?ioeea a eeoa/ieeo ?, ye iane?aeie, eiai
aoaeoeai?noue (A.I.Aiiaea?aiei o ni?aaao.,1995; A.I.Ei?ooiia o ni?aaao.,
1995).

I?iaeaia aeenaaeoa??ico eeoa/ieeo aei oaia??oiueiai /ano ? aeooaeueiith
? iio?aao? oaaae aeine?aeiee?a. O i?aeoe/iiio ieai? ianaiia?aae aaaeeeaa
cia/aiiy ia? ?ic?iaea iiaeo ? oaeineiiaeaiiy ?nioth/eo i?e?ia?ieia?/ieo
iaoiaee/ieo i?aeoiae?a aei aecia/aiiy noaio ii?iaeueii? i?e?ioei?e
eeoa/ieeo oa i?aeaeuaiiy aoaeoeaiino? i?aia?ao?a aoa?ioee?a aeey ??
ei?aeoe??.

?iaioa i?iaiaeeeanue o ?aieao IAe? “ ?ic?iaea oaoiieia??, i?aai?caoe?y
ae?iaieoeoaa oa ai?iaaaeaeaiiy a iaaee/io i?aeoeeo iiaeo eiiieaenieo
a?ini?aoe?eieo i?aia?ao?a, ye? ni?yiiaai? ia i?aeaeuaiiy
i?ioe?ioaeoe?eii? ?acenoaioiino?, aoaeoeaiino? ?ioiii?io?eaeoeee” (1994
?. – 1998 ?.). ? aea?ae?a?no?aoe?? 01940039053 ca ieaiii IIC Oe?a?ie.

Iaoa aeine?aeaeaiiy.

Oaeineiiaeaiiy i?e?ia?ieia?/ieo iaoiaee/ieo i?aeoiae?a aei aecia/aiiy
noaio i?e?ia?ioeaiico eeoa/ieeo oa ?ic?iaea noai i?aeaeuaiiy
aoaeoeaiino? aeei?enoaiiy aoa?ioe/ieo i?aia?ao?a.

Aeey ae??oaiiy aeaii? iaoe aoee iinoaaeai? ne?aeoth/? caaea/?:

1.Ca aeai?eiaeie iieacieeaie ioeiieoe yeiniee oa eieueeiniee neeaae
aa?iaii? oa aiaa?iaii? iie?ioei?e i?e aeenaaeoa?iici eeoa/ieeo
?icii? aoiieiai?.

2.I?iaanoe iiooe aeiiiiiaeieo iciae aeey ioeiiee ooieoeiiiaeueii?
aeoeaiinoi ie?aieo i?aaenoaaieeia iie?ioei?e eeoa/ieeo ethaeeie.

3.?ic?iaeoe aeai?eoii/ii iiaeoiaee aei ioeiiee aiioiii/ii? aeoeaiinoi
iie?ii?aaiiciia, aeaeieaieo i?e aeenaaeoa?iici eeoa/ieeo.

4.Aecia/eoe aoaeoeaiinoue aeayeeo oioiiniia aeey noiiniiai
aeei?enoaiiy ?o c aoaiioeeaie, ui aeei?enoiaothoue aeey eieoaaiiy
aeenaaeoa?iico eeoa/ieeo.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a.

Aia?oa iieacaii, ui i?e aecia/aiii ?iei ie?aieo aeaeia
iie?ii?aaiiciia o ?icaeoeo eeoeiaiai aeenaaeoa?iico ii?yae ic
eieueeinii-yeinieie iieacieeaie iie?iaiiai iaecaaeo eeoa/ieeo
iaiaoiaeii aecia/aoe i niiaaiaeiioaiiy ie?aieo eiai i?aaenoaaieeia
iiae niaith.Anoaiiaeaii ia?aaaao Aioa?iaaeoa?ia na?aae
oiiaii-iaoiaaieo aioa?iaaeoa?ie, ui coiiaeththoue aeenaaeoa?iic
eeoa/ieeo, iacaeaaeii aiae eieueeinieo iieacieeia aioiaeiaaeoa?ie oa
eaeoiaaoeee.

?ic?iaeaii aeai?eoii/ii iiaeoiaee aeey ioeiiee aiioiii/ii?
aeoeaiinoi iie?ii?aaiiciia, ui aeaeieaiii i?e aeenaaeoa?iici
eeoa/ieeo.

Iieacaia iiaeeeainoue iiaeaeuaiiy aiieiai/ii? aeoeaiinoi
aoaiioeeia, ui aoiaeyoue aei neeaaeo eiia?oeieieo aoaiioe/ieo
i?aia?oia, oeyoii iiae?iuoaaiiy ?o ia aiaeiiaiaeiie oioiiniiai.

Iaa?oioiaaii i?ioeiieacaiiy aeey aeei?enoaiiy eaeoiaaoeee aeey
eieoaaiiy aeenaaeoa?iico, ui coiiaeaiee ia?aaaaeii a?eaaie ?iaeo Nandida
spp.

Oai?aoe/ia oa i?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a aeine?aeaeaiiy.

Cai?iiiiiaaia aeiaeaoeiaa aeeth/aiiy aeiciaaiiai aeniao oaeaeie ic
?icaaaeaiiy 10 5 ia na?aaeiaeua Niiiina a i?aeoe/iiio ieaii
aeicaiey? ia`?eoeaicoaaoe ioeiieo ?iei oiiaii-iaoiaaieo
aioa?iaaeoa?ie o ?icaeoeo aeenaaeoa?iico eeoa/ieeo i oeei iiaeaeueoe
aoaeoeaiinoue eiai aaeoa?iieiai/ii? aeiaaiinoeee.

Cai?iiiiiaai? aeai?eoie ? eiaeia? /enea aeey ioe?iee a?io?i?/ii?
aeoeaiino? aeayeeo ?iae?a aioa?iaaeoa??e iineoaeeee iniiaith aeey
?ic?iaee i?ia?aie eiii’thoa?ii? ia?iaee ?acoeueoao?a aeine?aeaeaiiy ia
aeenaaeoa??ic eeoa/ieeo.

Anoaiiaeaia iiaeeeainoue iiaeaeuaiiy aiieiai/ii? aeoeaiinoi
aoaiioeeia, ui aoiaeyoue aei neeaaeo eiia?oeieieo aoaiioe/ieo
i?aia?aoia oeyoii iiia?aaeiueiai eoeueoeaoaaiiy ?o ia aiaeiiaiaeiie
oioiiniiai iiaea aooe aeei?enoaia aeey aeioneo aieueo aoaeoeaieo
aoaiioe/ieo i?aia?aoia aeey aoaeoeaiiai eieoaaiiy aeenaaeoa?iico
eeoa/ieeo.

Ia iniia? iaoa??ae?a aeena?oaoe?? aeaeai? oa ai?iaaaeaeai? o ?iaioo
aaeoa??ieia?/ieo eaai?aoi??e NAN oa e?ea?aiue iaoiaee/i? ?aeiiaiaeaoe??
“Ae?aaiinoeea oa e?eoaaiiy aeenaaeoa??ico eeoa/ieeo o ?aaiaoieia?/ieo
oai?eo” (Ee?a, 1999).

Iaoa?iaee aeena?oaoei? ai?iaaaeaeaii a iaaeaaiai/iee i?ioean
eaoaae?e iie?iaiieiai? EIAII oa a i?aeoeeo ?iaioe aaeoa?iieiai/ieo
eaai?aoi?ie e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a.

Iniaenoee aianie aaoi?a. Aaoi? iniaenoi aeeiiaea aenia?eiaioaeuei?
aeine?aeaeaiiy, ocaaaeueieea io?eiai? ?acoeueoaoe, i?iaaea ?o aiae?c oa
iaoaiaoe/io ia?iaeo c aeei?enoaiiyi no/anii? ia/enethaaeueii? oaoi?ee,
oaeineiiaeeea iaoiaeeeo ae?aaiinoeee aeenaaeoa??ico eeoa/ieeo, ?ic?iaeea
aeai?eoie oa eiaeia? /enea aeey a?io?i?/ii? ioe?iee aioa?iaaeoa??e,
aeine?aeeea a?inoi?ni?noue eaeoiaaoeee ?c o?oiiniiaaie ? ni?aaioaie, ui
aeicaieeei ?aeiiaiaeoaaoe iiaee niin?a aeei?enoaiiy aeaiiai aoa?ioeea
aeey ei?aeoe?? i?e?ia?ioeaiico eeoa/ieeo i?e aeenaaeoa??icao.

Ai?iaaoe?y ?iaioe ? ioae?eaoe?? ii oai? aeena?oaoe??.

?acoeueoaoe ?iaioe aena?oeaii o 13 iaoeiaeo i?aoeyo, a oiio /ene? o 2-o
aeo?iaeueieo noaooyo, 7-ie ca??ieeao iaoeiaeo i?aoeue, c yeeo 5 i?aoeue
a i?ia?aeieo AAEianueeeo aeaeaiiyo, 4 oacao iaoeiaeo aeiiia?aeae,
aeaeaii iaoiaee/i? ?aeiiaiaeaoe??.

?acoeueoaoe ?iaioe aoee i?aaenoaaeai? ia:

OIII c`?caei Oe?a?inueeiai iaoeiaiai oiaa?enoaa iie?iaiieiaia,
aiiaeaiiieiaia oa ia?aceoieiaia (Ee?a-Aiiieoey,1996); 1-?e
iaoeiai-i?aeoe/iie eiioa?aioei? EIAII i IAII «E?aiia» «Aiini?aoeieii
iaoiaee i i?aia?aoe a i?ioieaeoe/iie oa eieoaaeueiie i?aeoeoei»
(Ee?a,1997); iaoeiai-i?aeoe/iie eiioa?aioei? a/aieo EIAII ii
caeii/aieo oa ia?aoiaeieo IAe? ca 1990-1996 ?iee (Ee?a,1997);
?aaiiiaeueiie eiioa?aioei? «Oi?ioaaiiy caei?ia`y ianaeaiiy a
Aea?ieoeueeiio ?aeiii i.Ee?aa» (Ee?a, 1997); 20-e thaieaeiie
eiioa?aioei? iieiaeeo a/aieo EIAII (1997); tha?eaei?e eiioa?aioe??,
i?enay/ai?e 80- ??//th EIAII ?i. I.E.Ooieea (1998).

Ianya ? no?oeoo?a aeena?oaoe??. ?iaioa aeeeaaeaia ia 118 noi?iieao
iaoeiiieniiai oaenoo oa neeaaea?oueny ic anooio, iaeyaeo eioa?aoo?e,
4 ?icaeieia aeanieo aeineiaeaeaiue, caeeth/aiiy, aeniiaeia. Nienie
eioa?aoo?e aeeth/a? 161 aeaea?aei aio/eciyii? oa ca?oaiaeii?
eioa?aoo?e. Iaoa?iaee aeena?oaoei? iethno?iaaii 15 oaaeeoeyie, 9
iaethieaie, 2 aeiaeaoeaie.

IAOA??AEE ? IAOIAeE AeINE?AeAEAIIss

Aeey aeeiiaiiy ?iaioe ianoaaeaii iaoa?iae aiae 298 oai?eo c
eeiii/ieie aeiaaiicaie aeenaaeoa?iic oa ?icieie aeenooieoeiyie
eeoa/ieeo i 67 oai?eo c iiieiaith oai?iaith.

Ia`?eoii aeineiaeaiiy aoee oaeaeueii iane aiae iaia/aieo oai?eo, ui
ciaoiaeeeenue ia eieoaaiii a Oe?a?inueeiio iiieiaiio oeaio?i, oa
oai?eo, ui caa?oaeenue aei Aea?ieoeueeiai ?aeiiiiai iaaee/iiai
ia`?aeiaiiy.

Aeey ioeiiee noaio iie?iaiioeaiico eeoa/ieeo aeei?enoiaoaaeenue oaei
iieacieee: iayaiinoue eaeoiaaoeee, aioiaeiaaeoa?ie, eeoeiai? iaee/ee
c ii?iaeueiith oa?iaioaoeaiith aeoeaiinoth, ic ciiiaiith
ooieoe??th oa?iaio?a, a oiio /enei i eaeoiciiaaaoeaieo
aiioiii/ieo aa?iaioia, a oaeiae iayaiinoue oiiaii-iaoiaaieo
iie?ii?aaiiciia (OII) i a?eaia (A.A.Ciaiainueeee o ni?aaao.,1986).

?aeaioeo?eaoe?y aeae?eaieo i?e?ii?aai?ci?a aaeanue oeyoii aea/aiiy ?o
oa?iaioaoeaieo aeanoeainoae ye ia eeane/ieo
aeeoa?aioe?aeueii-ae?aaiinoe/ieo na?aaeiaeuao, oae ? c aeei?enoaiiyi
nenoai ?iaeeeaoi?ieo iaia?iaeo (N?I).

Aeey aeeoa?aioe?aoe?? eeoeiaeo aaeoa??e aeei?enoiaoaaee nenoaio A?? –20
A (O?aioe?y) oa i?e?ioanoe 1 ? 2 (*ao?y).

Aecia/aiiy aeaeiai? iaeaaeiino? iie?ii?aaiiciia i?iaiaeeee ca
caaaeueiii?eeiyoeie iie?iaiieiai/ieie noaiaie c aeei?enoaiiyi
?ic?iaeaieo iaie aeai?eoii/ieo iiaeoiaeia (I.?.I?eieuenueea a ni?aaao.,
1996). Aioaaii?noe/io aeoeai?noue i?aaenoaaiee?a ii?iaeueii? i?e?ioei?e
eeoa/ieeo aecia/aee iaoiaeii a?aeno?i/aiiai aioaaii?cio.

Aeey aea/aiiy aiinoiiniinoi eaeoiaaeoa?ie ic oioiiniiaaie aoa
aeei?enoaiee ooai Lactobacillus plantarum 8 PA-3 ic ioioeiiaeueiiai
i?aia?aoo «Eaeoiaaeoa?ei nooee». A yeino? o?oiiniia aoee aeine?aeaeai?
eaionoa, iiaei?iaeiee aaeeeee, o?ueioeieuei?iaa o?aeea, /a?aaea
o?e?icae?eueia, ?iiaoea e?ea?nueea, aeoay e?ea?nueea 1% oa 5%
eiioeaio?aoe?e ? a ??cieo niieo/aiiyo.

A yeino? aioa?ini?aaioo aeey eiino?othaaiiy aoa?ioeei-o?oi-ni?aoe?eii?
eiiiiceoe?? aoa aeei?enoaiee “Aioa?inaaeue” (A.I.A?eoeaiei o ni?aaao.,
1994)

Aeey aecia/aiiy a?inoi?niino? eaeoiaaoeee ?c o?oiiniiaaie aea/eee ?o
?inoiao aeoeai?noue, aeooaeueio aeoeai?noue oa aioaaii?noe/io
aeoeai?noue ca caaaeueiii?eeiyoeie iaoiaeeeaie (A.E.Eaanieeia o
ni?aaao., 1983).

Ia?iaea iaea?aeaieo ?acoeueoao?a aeine?aeaeaiiy i?iaiaeeeanue ca
aeiiiiiaith iaeaoo i?eeeaaeieo i?ia?ai aeey ia?iaee iaoeiaeo
iaaeeei-a?ieia?/ieo aeineiaeaeaiue «STATGRAPHICS» ia IAAI “PENTIUM-2”
(I.I.I?ioea? a ni?aaao.,1996).

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe

I?iaaaeaii aeineiaeaeaiiy ii oaeineiiaeaiith iaoiaee/ieo iiaeoiaeia
uiaei ioeiiee eeoeiaiai iie?iaiioeaiico i io?eiaii ia ?o iniiai
?acoeueoaoe, aeathoue ciiao ca anoaiiaeaieie aeai?eiaeie iieacieeaie
ioeiithaaoe yeiniee oa eieueeiniee neeaae aa?iaii? oa aiaa?iaii?
iie?ioei?e eeoa/ieeo a ii?ii i i?e iaoieiai?.

I?e oeueiio iieacaii, ui i?e aecia/aiii i?ia?aeii? ?iei ie?aieo
aeaeia iie?ii?aaiiciia o ?icaeoeo aeenaaeoa?iico eeoa/ieeo ii?yae ic
eieueeinii-yeinieie iieacieeaie iie?iaiiai iaecaaeo eeoa/ieeo
iaiaoiaeii aecia/aoe i niiaaiaeiioaiiy ie?aieo eiai i?aaenoaaieeia
iiae niaith, ui iiaeaeuo? aeinoiai?iinoue ?acoeueoaoia
iie?iaiieiai/ii? aeiaaiinoeee aeenaaeoa?iico eeoa/ieeo.

Aiaeic i?iaaaeaieo aeineiaeaeaiue iieacaa, ui a ieiioiie
aeieiai/iie neooaoei? o oai?eo ic eeiii/ieie ae?aiicaie
«aeenaaeoa?iic» oa iioeie aeenooieoeiyie eeoa/ieeo aaeoa?iieiai/ii
aeenaaeoa?iic eeoa/ieeo aeyaeaii o 264 (88,6 %) oai?eo. Aii
oa?aeoa?ecoaaany ia?inoaiiyi eieueeinoi oiiaii-iaoiaaieo iie?ii?aaiiciia
(57,5 %), iiyaith eeoeiaeo iaee/ie ic ciiiaieie aeanoeainoyie (10,2
%) oa aaiieioe/ieo aeaeia (32,6 %); aiae 24,2 % oai?eo aeaeieyeenue
cieioenoi noaoieieiee; aiae 19,7 % oai?eo aeaeieyeenue a?eae
?iaeo Nandida spp.; o 12,1 % oai?eo niinoa?iaaeinue cieaeaiiy
caaaeueii? eieueeinoi eeoeiaeo iaee/ie (Iae. 1).

Iae.1 Oa?aeoa?enoeea oiiaii-iaoiaaii? ? aiaa?iaii? i?e?ioei?e i?e
aeenaaeoa??ic? eeoa/ieeo a caeaaeiino? a?ae ni?aa?aeiioaiiy e?eueeino?
eaeoi- oa a?o?aeioei?e.

Ii?ooaiiy a neeaaei iie?iaiioeaiico eeoa/ieeo i?e ii?iaeueiie
eieueeinoi Bifidobacterium spp. (> 10 7) niinoa?iaaeinue o 84,1 %, a i?e
ii?iaeueiie eieueeinoi Lactobacillus spp. (>10 6) aeenaiioe/ii ii?ooaiiy
niinoa?iaaeenue o 59,5% aeiaaeeia.

Iieacaii, ui i i?e iayaiinoi ia ?iaii ii?ie eaeoiaaoeee i
aioiaeiaaeoa?ie /anoi aeniaathoueny cieioenoi noaoieieiee, eeoeiai
iaee/ee ic ciiiaieie aeanoeainoyie (eaeoiciiaaaoeaii oa aaiieioe/ii
aeaee), a?eae ?iaeo Nandida spp. oa oiiaii-iaoiaaii iie?ii?aaiicie,
na?aae yeeo ia?aaaaea? Enterobacter spp. Oaeiae iieacaii a?aenooi?noue
ei?aeyoei? iiae eieueeinoth eaeoiaaoeee i aioiaeiaaeoa?ie a
neeaaei iie?ioei?e eeoa/ieeo.

A ?acoeueoaoi aeineiaeaeaiiy iie?ioei?e eeoa/ieeo o oai?eo c
ii?eaie ??ciiai nooiaith anoaiiaeaii, ui ia 3-4 aeiao o anio aac
aeiyoeo oai?eo ?icaeaa?oueny aeenaaeoa?iic eeoa/ieeo.

Iacaeaaeii aiae aieo oai?eo iiiee o anio aeiaaeeao
noi?iaiaeaeothoueny aiaenooiinoth eaeoiaaoeee a eieueeinoi, oa?aeoa?iie
aeey ii?iiiie?iaiioeaiico eeoa/ieeo.

Aioiaeiaaeoa?i? ia ieaeiie iaaei ii?ie aoee aeyaeaii oieueee a 29,4 %
aeiaaeeia.

Ia?inoaiiy eieueeinoi oiiaii-iaoiaaii? iie?ioei?e aeua
aeiionoeii? ii?ie ia 3-4 aeiao niinoa?iaaeinue o 75-100 % oai?eo.

Aiaeii/aii, ui ii?ooaiiy aa?iaii? i oaeoeueoaoeaii-aa?iaii? eaiee
iie?iaiioeaiico eeoa/ieea coiiaeaia ia?inoaiiyi oaeeo aeaeia
oiiaii-iaoiaaieo iie?ii?aaiiciia: Klebsiella spp., Enterobacter
spp., Citrobacter spp., S.aureus, a?eaia ?iaeo Candida spp. a
cia/iie eieueeinoi aeiaaeeia aiaeii/aii iiyao ciiiaieo aeaeia eeoeiai?
iaee/ee.

Anoaiiaeaii, ui i?e iiieiaie oai?iai o anio aieiaeo a?oiao ia oiii
aacenii? oa?aii? ?icaeaa?oueny aeenaaeoa?iic eeoa/ieeo, ui coiiaeth?
aiaeiiioieneeaoeith i?aaiicio.

I?iaaaeaieie aeine?aeaeaiiyie iieacaii, ui aeenaaeoa??ic eeoa/ieeo
?icaeaa?oueny iacaeaaeii a?ae e?euee?nieo iieaciee?a i?aaenoaaiee?a eiai
ii?iaeueii? i?e?ioei?e, ui aeaco? ia ye?ni? ci?ie oeeo i?e?ii?aai?ci?a.

Naia oiio, iaie aea/aia aioaaii?noe/ia aeoeai?noue eaeoiaaoeee ?
eeoeiaeo iaee/ie aeae?eaieo i?e aeenaaeoa??ic? eeoa/ieeo.

Anoaiiaeaii, ui i? iaeia eoeueoo?a eeoeiai? iaee/ee ? eaeoiaaoeee, ye?
aoee aeae?eai? i?e aeenaaeoa??ic? eeoa/ieeo, ia a?aei?io a?ae eeoeiai?
iaee/ee ? eaeoiaaoeee, ui aoiaeyoue aei neeaaeo aoa?ioe/ieo i?aia?ao?a,
ia i?iyaeyee aioaaii?noe/io aeoeai?noue a?aeiinii iaoiaaii? ?
oiiaii-iaoiaaii? i?e?ioei?e. Oea ? aeieacii ae?aaeaiiai cieaeaiiy
ooieoe?iiaeueii? aeoeiino?

i?e?iaieo anioe?aoe?e oianoi? eeoee, ui ni?ey? no?eeiio oa?aeoa?o
aeena?ioe/ieo ci?i o oai?eo. Io?eiai? ?acoeueoaoe iaa?oioiaothoue
iaiao?aei?noue aecia/aiiy aioaaii?noe/ii? aeoeaiino? iniiaieo caoenieo
a?oi i?e?ii?aai?ci?a aeey ioe?iee ooieoe?iiaeueiiai noaio eeoeiaiai
i?e?ia?ioeaiico ? iaa?oiooaaiiy niiniao ?aoe?iiaeueii? oa?ai?? aeyaeaieo
ii?ooaiue.

Iaeiei c caaaeaiue ?iaioe ? oaeineiiaeaiiy i?e?ia?ieia?/ieo noai
ae?aaiinoeee aeenaaeoa??ico eeoa/ieeo. C oe??th iaoith iaie
?aeiiaiaeiaaii aeiaeaoeiai i?e aeine?aeaeai? ia aeenaaeoa??ic eeoa/ieeo
?iaeoe aeiciaai? aen?ae iaoa??aeo ?c ?icaaaeaiiy 10 7 ia na?aaeiaeua
Aiaei, ui aeicaiey? a?eueo /?oei i?ae?aooaaoe e?euee?noue eieii?e
eeoeiai? iaee/ee ?, ii iiaeeeaino?, oieeiooe iiaco/iai ?inoo i?ioa?a.

Aeey e?euee?niiai aecia/aiiy eaeoiaaoeee iaiao?aeii ?c ?icaaaeaiiy 10 5
aeiciaaii iaoa??ae aen?aaoe ia iiaeeo?eiaaia iaie (u?eueia) na?aaeiaeua
I?N – 4, ui aea? iiaeeea?noue i?ae?aooaaoe eaeoiaaoeeee a EOI ia 1 ie
(A.?.Eenaiei o ni?aaao.,1999)

C iaoith iie?auaiiy ?icoeo?iaee oiiaii-iaoiaaieo ai?iaaeoa??e (OIA) oa
aecia/aiiy ?o ?ie? o ?icaeoeo aeenaaeoa??ico eeoa/ieeo ethaeeie
aeiaeaoeiai aei o?aaeeoe?eii? noaie iin?ao iaie cai?iiiiiaaii
ia?aeaeueii ?iaeoe aeiciaai? aen?ae iaoa??aeo ?c ?icaaaeaiiy 10 5 ia
ieanoei/aia na?aaeiaeua N?iiina ? Aiaei. A?eueo?noue aeae?a
oiiaii-iaoiaaieo aioa?iaaeoa??e (OIA) ?inoooue ia na?aaeiaeu? N?iiina, a
eeoeiaa iaee/ea – i?. Iiaee iaoiaee/iee i?aeo?ae iieyaa? o oiio, ui o?
?iaee OIA, ye? ia canaiththoue oeeo?ao iao??th, /e a?aeiinyoueny aei
iueiai aa??aaaeueii (Edwardsiella, Hafnia, Proteus, Morganella) ia
canaiththoue oaeiae ? eaeoico (I.?.I?eieuenueea o ni?aaao., 1997). Oaeei
/eiii /a?ac 24 aiaeeie ?inoo ia na?aaeiaeuao Aiaei ? N?iiina iiaeooue
aooe 4 aa??aioe a?aeiia?ae?: (Oaae.1).

Oaaeeoey 1.

Aa??aioe ?inoo aioa?iaaeoa??e ia na?aaeiaeuao Aiaei ? N?iiina i?e
aecia/aii? ?ie? oiiaii-iaoiaaieo aioa?iaaeoa??e o ?icaeoeo
aeenaaeoa??ico eeoa/ieeo.

Aa??aio Na?aaeiaeua Aiaei Na?aaeiaeua N?iiina Aeniiaie

1. Eieii?? eaeoici (+) iaia? ?inoo iaia? OIA

2. Eieii?? eaeoici (-) ? ??no iayai?noue OIA

3. Eieii?? eaeoici (+) ? eaeoici (-) ? ??no iayai?noue OIA

4. Eieii?? eaeoici (+) ? eaeoici (-) iaia? ?inoo eaeoici (-) E. coli

?c na?aaeiaeua Aiaei (aa??aio 2-4) a?aeae?aee an? oeie eieii?e ia
na?aaeiaeua Ieueeaieoeueeiai ? neioaia na?aaeiaeua N?iiina. C
ieanoei/aoiai na?aaeiaeua N?iiina a?aeae?aee an? oeie eieii?e ia
na?aaeiaeua Ieueeaieoeueeiai. Aeaeueoa o aeiaaeeo iaeeiaeiai?
oa?iaioaoe?? na?aaeiaeua Ieueeaieoeueeiai aeinoaoiuei noaaeoe iaeei
a?io?i?/iee ?yae aeey e?ioeaai? ?aeaioeo?eaoe??. Iieacaii, ui oaeee
niin?a aeei?enoaiiy na?aaeiaeua N?iiina aea? iiaeeea?noue noaeeoe i?i
iayai?noue OIA oa ?o e?euee?noue oaea /a?ac 24 aiaeeie c iiiaioo iin?ao,
cai?noue 48-72 aiaeei. Ia?aeiia ?icoe?aiiy iaai?o iiaeeaieo na?aaeiaeu
i?e iin?a? a iiaeaeueoiio nei?i/o? ia’?i ?iaioe, aea? aeiiii?th
iiaeeaieo na?aaeiaeu ? ?iai/iai /ano. Canoinoaaiiy na?aaeiaeua N?iiina
oaeiae aeeeth/a? anioe?aoe?? OIA ? eeoeiai? iaee/ee, ui a?aeiia?aeii
?iaeoue ?acoeueoaoe i?ae?aooieo a?eueo aeinoia??ieie, /ei i?e cae/aei?e
iaoiaeeoe?.

C iaoith iioei?caoe?? i?e?ia?ieia?/ii? ae?aaiinoeee aeenaaeoa??ico
eeoa/ieeo iaie aoee aeei?enoaii? aeai?eoi?/i? i?aeoiaee uiaei ioe?iee
a?io?i?/ii? aeoeaiino? aeae?eaii? i?e?ioei?e. Aeey aeeoa?aioe?aoe??
?iaeiaeo a?oi n?iaenoaa Enterobacteriacaaa, ie aeei?enoiaoaaee iaea?eueo
?ioi?iaoeai?, ia iao iiaeyae, a?io?i?/i? iciaee (9 oano?a), ye? aeaee
iai ciiao ?icae?eeoe i?e?ii?aai?cie ia ie?ai? a?oie ? ca 3-5 “e?ie?a”
aeiaanoe aei ?iaeo (aeai?eoi).

Aeey aecia/aiiy eiaeiaeo /enae i?e?ii?aai?ci?a, oe? iciaee aoee
?iciiae?eai? a iaai?e iine?aeiaiino? ? ?icaeo? ia o?eieaoe. Aeey
eiaeiiai ?iaeo, a ii iiaeeeaino? ? aeaeo ie aecia/eee nai? eiaeia?
/enea, ui aea? iiaeeea?noue e?ea?th oaeaeei i?iaanoe ?aeaioeo?eaoe?th
i?e?ii?aai?ci?a. Oaeee aeai?eoi?/iee i?aeo?ae iineoaeea iniiaith aeey
?ic?iaee i?ia?aie eiii’thoa?ii? ia?iaee ?acoeueoao?a aeine?aeaeaiiy ia
aeenaaeoa??ic eeoa/ieeo.

Iaie oaeiae ?ic?iaeai? ni?iuai? noaie ia?aeiii? a?io?i?/ii?
?aeaioeo?eaoe?? aeayeeo ?iae?a aioa?iaaeoa??e.

Ana oea ?acii ?iaeoue ae?aaiinoeeo aeenaaeoa??ico a?eueo aoaeoeaiith,
aea? iiaeeea?noue aeei?enoiaoaaoe eiii’thoa?io ia?iaeo ?acoeueoao?a
aeine?aeaeaiiy ia aeenaaeoa??ic, ui iioei?co? ae?aaiinoeeo.

Eeth/iaei iiiaioii ?iaioe aoea ?ic?iaea aoa?ioeei-o?oi-ni?aoe?eii?
eiiiiceoe?? aeey ei?aeoe?? aeenaaeoa??ico eeoa/ieeo.

C oe??th iaoith iaie aoea aea/aia a?inoi?ni?noue ??cieo o?oiiniia
(o?oia?aeaa? ? aeiaaaee) ? eaeoiaaoeee (L. plantarum 8-?A-3) ii
e?eueeino? aeeoo?caeaoieo ee?oei (EOI/ie), nooiai? caeeneaiiy
na?aaeiaeua ?inoo, aeooaeueii? aeoeaiino? ii Oa?ia?o.

Aeai? oeeo aeine?aeaeaiue iaaaaeai? a oaae. 2. sse aeaeii ?c oaaeeoe?,
iayai?noue a o?oia?aeaa?? aeiaaaee (naoa?ice ? oeenoeio) i?aeaeuo?
a?ieia?/io aeoeai?noue eaeoiaaoeee. Acyo? ca aeo?aei? neaaeieene?
cia/aiiy eeneioii-eoaeii? ??aiiaaae pH (5,9 ( 0,3) ni?eythoue neioaco
iiei/ii? eeneioe. Oea aaaeeeai, oae ye naia iiei/ia eeneioa ia?aaaaeii
coiiaeth? aioaaii?noe/io aeoeai?noue eaeoiaaoeee a?aeiinii iaoiaaii? ?
oiiaii-iaoiaaii? i?e?ioei?e o?aaiiai o?aeoo (Eaanieeia A.E., 1975).

Iaeiei ?c nooo?aeo iiiaio?a eiino?othaaiiy aoa?ioeei-o?oi-ni?aoe?eii?
eiiiiceoe?? ? aecia/aiiy nooiaith aioaaii?noe/ii? aeoeaiino? eaeoiaaoeee
i?ney ae?iuoaaiiy ?o ia o?oiiniia?. A ?acoeueoao? anoaiiaeaii, ui
eaeoiaaoeeee i?ney ae?iuoaaiiy ?o ia o?oina?aaeiaeuao ia cieaeothoue, a
?iiae? ? i?aeaeuothoue naith aioaaii?noe/io aeoeai?noue. Ioaea

Oaaeeoey 2

??no ? eeneioiooai?aiiy eaeoiaaoeee (L.plantarum 8-PA-3) i?e ae?iuoaaii?
?o ia o?oia?aeaa?? ? o?oiiniiaao.

Aa??aio o?oia?aeaa?o ? o?oiiniiae Iieacieee a?ieia?/ii? aeoeaiino?
(/a?ac 24 aiaeeie)

E?ioeaaa eiioeaio?aoe?y i?e?ii?aai?ci?a (EOI/ie)* E?ioeaaee ??aaiue ?I
Aeooaeueia eeneioi?noue (O0)**

1.A?aeaa? iiaei?iaeieeo (1%) 3,2 o 10 7 3,75 ( 0,1 22

1.1.A?aeaa? iiaei?iaeieeo (1%)

+naoa?ica (1%)

+oeenoei (0,01%) 3,1 o 10 6 3,25±0,15 60

2.A?aeaa? eaionoe (1%) 7,0 o 10 7 3,7±0,2 19

2.1.A?aeaa? eaionoe (1%)

+naoa?ica (1%)

+oeenoei (0,01%) 6,6 o 10 8 3,4±0,1 41

3.A?aeaa? o?aeee (1%) 2,8 o 10 7 4,8±0,5 10

3.1.A?aeaa? o?aeee (1%)

+naoa?ica (1%)

+oeenoei (0,01%) 6,5 o 10 8 3,6±0,2 49

4.Noi?o a?aeaa??a o?aeee ? /a?aaee (1:1) 3,1 o 10 7 4,0±0,15 19

4.1.Oa ae noi?o a?aeaa??a

+naoa?ica (1%)

+oeenoei (0,01%) 7,2 o 10 8 3,8±0,1 45

5.A?aeaa? oeieio (1%)

+naoa?ica (1%)

+oeenoei (0,01%) 4,8 o 10 5 5,75±0,05 —

6. A?aeaa? oeoie a?eueoe (5%) 10 5 5,8±0,2 0

6.1 A?aeaa? oeoie a?eueoe (5%)

+naoa?ica (1%)

+oeenoei (0,01%) 1,5 o 10 7 4,7±0,2 10

* — aeo?aeia eiioeaio?aoe?y – 2,0 – 3,0 o 10 5 EOI/ie;

**-eiioeaio?aoe?y, coiiaeaia iayai?noth iiei/ii? eeneioe, ye?nia i?iaa
ca Oooaeueiaiii.

iniiai? aeanoeaino? eaeoiaaoeee- oa?iaioaoeaia ? aioaaii?noe/ia – ia
o?oina?aaeiaeuao caa??aathoueny, ui na?ae/eoue i?i aenieo a?inoi?ni?noue
aoa?ioeea ? o?oieiiiiiaioo.

C iaoith i?aeai?o iaea?eueo iioeiaeueii? o?oiiniiae aeey eaeoiaaoeee
aoei aea/aii ?o ?iciiiaeaiiy ia ??cieo o?oiiniiaao 1% ? 5%
eiioeaio?aoe?? oa a ??cieo niieo/aiiyo.

Iieacaii, ui naiith iioeiaeueiith o?oiiniiaith ? ?iiaoea e?ea?nueea
(Iae.2). Oae /a?ac 4 aiaeeie ?inoo eiioeaio?aoe?y i?e?ii?aai?ci?a
c?inoa? ia 3 ii?yaeee ? aeinyaa? N o 10 9 EOI/ie ? caeeoa?oueny ia
oeueiio ??ai?, ia a?aei?io a?ae ?ioeo o?oiiniia.

Iaiao?aeii aoei oaeiae aea/eoe a?inoi?ni?noue eaeoiaaoeee ?c ni?aaioii a
o?oina?aaeiaeu?. Aoei aeine?aeaeaii a?ieia?/io aeoeai?noue eaeoiaaoeee
(??no ? eeneioiooai?aiiy) a ??aeeiio o?oina?aaeiaeu? a i?enooiino?
??cieo eiioeaio?aoe?e aioa?ini?aaioo.

Anoaiiaeaii, ui “Aioa?inaaeue” a e?eueeino? a?ae 1,0% aei 10,0 % a
noi?o? ?c o?oina?aaeiaeuaie ia cieaeo? a?ieia?/io aeoeai?noue aoa?ioeea;
nooi?iue eeneioiooai?aiiy ? iaeiie/aiiy aeeoo?caeaoieo ee?oei
caeeoa?oueny ia ??ai? eiio?ieth. Oiaoi, niinoa??aa?oueny aeniea
a?inoi?ni?noue aoa?ioeei-o?oi-ni?aoe?eii? eiiiiceoe??.

I?e aecia/aii? aioaaii?noe/ii? aeoeaiino? eaeoiaaoeee aoei iieacaii, ui
i?e ni?eueiiio ae?iuoaaii? ?o ?c ae??aeaeaeiiiae?aieie a?eaaie ?iaeo
Candida spp. c?inoa? e?euee?noue inoaii?o. Oea iaa?oioiao?
i?ioeiieacaiiy aeey aeei?enoaiiy “Eaeoiaaeoa?eio nooiai” aeey ei?aeoe??
aeenaaeoa??ico coiiaeaiiai ia?aaaaeii ae??aeaeaeiiiae?aieie a?eaaie
?iaeo Candida spp.

Iae. 2 ?iciiiaeaiiy eaeoiaaoeee ia 5 % o?oiiniia?.

AENIIAEE

Anoaiiaeaii, ui i?e aecia/aii? ao?ieia?/ii? ?ie? ie?aieo aeae?a
i?e?ii?aai?ci?a o ?icaeoeo eeoeiaiai aeenaaeoa??ico ii?yae ?c
e?euee?nii-ye?nieie iieacieeaie iaiao?aeii aecia/aoe aca?iia?aeiioaiiy
ie?aieo aeae?a i?ae niaith. Aeieacaii ia?aaaao Aioa?iaaeoa??a na?aae OIA
iacaeaaeii a?ae e?euee?nieo iieaciee?a a?o?aeiaaeoa??e ? eaeoiaaoeee.
Aecia/aiiy aioaaii?noe/ii? aeoeaiino? iniiaieo caoenieo a?oi
i?e?ii?aai?ci?a aeioe?eueii aeei?enoiaoaaoe aeey ioe?iee
ooieoe?iiaeueiiai noaio eeoeiaiai i?e?ia?ioeaiico ? iaa?oiooaaiiy
niiniao ?aoe?iiaeueii? ei?aeoe?? aeyaeaieo ii?ooaiue.

Aia?oa cai?iiiiiaaii i?e aeine?aeaeaii? ia aeenaaeoa??ic eeoa/ieeo
?iaeoe ia?aeaeuei? aeiciaai? aen?ae iaoa??aeo ?c ?icaaaeaiiy 10 5
ia na?aaeiaeua Aiaei ? ieanoei/aoa na?aaeiaeua N?iiina, ui aeicaiey?
aeaoe ia’?eoeaio ioe?ieo ?ie? oiiaii-iaoiaaieo aioa?iaaeoa??e o ?icaeoeo
aeenaaeoa??ico eeoa/ieeo. Aeey aecia/aiiy eaeoiaaoeee iaoa??ae ?c
?icaaaeaiiy 10 5 aeiciaaii aen?aaoe ia, iiae?o?eiaaia iaie, oaa?aea
na?aaeiaeua I?N-4.

Aia?oa cai?iiiiiaai? ni?iuai? noaie ia?aeiii? a?io?i?/ii?
?aeaioeo?eaoe?? aeayeeo ?iae?a aioa?iaaeoa??e, eiaeia? /enea ? aeai?eoi
ioe?iee a?io?i?/ii? aeoeaiino? i?e?ii?aai?ci?a, ui noaee iniiaith aeey
?ic?iaee i?ia?aie eiii’thoa?ii? ia?iaee ?acoeueoao?a aeine?aeaeaiiy ia
aeenaaeoa??ic eeoa/ieeo.

Cai?iiiiiaaia iioeiaeueia o?oiiniiaa – ?iiaoea e?ea?nueea aeey
iiia?aaeiuei? aeoeaaoe?? eiia?oe?eieo ooai?a eaeoiaaoeee. ?aeiiaiaeiaaii
eiiieaenia aeei?enoaiiy aoa?ioeei-o?oi-ni?aoe?eii? eiiiiceoe?? aeey
ei?aeoe?? i?e?ia?ioeaiico eeoa/ieeo i?e aeenaaeoa??ic?.

Iieacaii, ui aoa?ioe/iee i?aia?ao “Eaeoiaaeoa?ei nooee” i?aeaeuo?
eieii?caoe?ei? aeanoeaino? ae??aeaeaeiiiae?aieo a?ea?a ?iaeo Candida
spp. Iaaeioe?eueii aeei?enoiaoaaoe eeneioiooai?thth/? i?aia?aoe aeey
ei?aeoe?? aeenaaeoa??ico eeoa/ieeo, iaoiiaeaiiai ia?aaaaeii
ae??aeaeaeiiiae?aieie a?eaaie ?iaeo Candida spp.

Nienie iioae?eiaaieo iaoeiaeo i?aoeue ca oaiith aeena?oaoe??

A.?.Eenaiei, E.A.Oanethe, I.?.I?eieuenueea. Noai eeoeiaiai
i?e?ia?ioeaiico o oai?eo ?aaiaoieia?/iei oa ?aaeoeaiei a?o?eoaie //
AEo?iae i?aeoe/iiai e?ea?y. – 1999. — ? 1. – N. 36-37.

?.E.Iaeeaiei, A.E.Ieeieueneay. Aioeaaeoa?eaeueiay oa?aiey iaiaeieii a
eiiieaeniii ea/aiee oieaiaeoa // Aiaeu oe?o?ae/aneie
aaiaoieiaee.-1998.-oii 3.- ? 8.- N. 292-294.

Ciaiainueeee A.I., Aieeiaa A.I., A?ey?aa I.I. Oaeeiaa I.A., I?eieuenueea
I.?. E?eoaaeueii-i?io?eaeoe/i? i?ia?ioeei-o?oi-ni?aoe?ei? eiiiiceoe??
//Ca. iaoeiaeo i?aoeue ni?a?ia?oiee?a EIAII ii cae?i/aieo oa ia?ao?aeieo
IAe? ca 1990-1996 ?iee.- Ee?a.- 1997.- N.266-268.

I?eieuenueea I.?. Aea/aiiy a?inoi?niino? eaeoiaaoeee ?c ni?aoe?eieie
iaoa??aeaie ? o?oina?aaeiaeuaie //- oai aea. N.460-461.

I?eieuenueea I.?., Oaeeiaa I.A. Aeine?aeaeaiiy i?e?ia?ioeaiico eeoa/ieea
? oe??e i?e ii?eia?e ?ioieneeaoe?? oa iaoiaee ?? ni?aoe?eii?
aeaoieneeaoe?? //A?ini?aoe?ei? iaoiaee ? i?aia?aoe a i?io?eaeoe/i?e oa
e?eoaaeuei?e i?aeoeoe?: I?aoe? ia?oi? iaoeiai-i?aeoe/ii? eiioa?aioe??
–Aei.1-e: EIAII- 1997.-N.113-116.

Ieeieueneay A.E., Aa?aiaa A.E. Eneonnoaaiii neioace?iaaiiua ni?aoeeiiiua
i?aia?aou e eo ianoi a ai?ueaa n aeea?aeiuie aieaciyie //Ca. iaoe.
i?aoeue 20– ? tha?eaeii? eiioa?aioe?? iieiaeeo a/aieo Ee?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe IIC Oe?a?ie.-Ee?a,
1997.-N.363-370.

I?eioeei eiino?othaaiiy e?eoaaeueii-i?io?eaeoe/ii? eiiiiceoe?? aeey
ei?aeoe?? aeenaaeoa??ic?a. Iia?aeiieaiiy 1. Aeine?aee in vitro. /
A.I.Ciaiainueeee, A.I.Aieeiaa A.I..Oaeeiaa, I.?.I?eieuenueea,
A.I.I?ieiiaoeue. //Aeooaeuei? ieoaiiy iaaee/ii? i?e?ia?ieia?? oa
a??onieia??: Ca. aei 100 – ??//y a?ae aeiy ia?iaeaeaiiy
N.N.Aey/aiea.-Ee?a, 1998.-N.-51-54.

Ciaiainueeee A.I., Aieeiaa A.I., Oaeeiaa I.A., I?eieuenueea I.?.,
I?ieiiaoeue A.I. I?eioeei eiino?othaaiiy e?eoaaeueii-i?io?eaeoe/ii?
eiiiiceoe?? aeey ei?aeoe?? aeenaaeoa??ic?a. Iia?aeiieaiiy 2. E?eoaaeueia
ao?eoeai?noue i?e aeena?icao eeoa/ieeo //Aeooaeuei? ieoaiiy iaaee/ii?
i?e?ia?ieia?? oa a??onieia??: Ca. aei 100 – ??//y a?ae aeiy ia?iaeaeaiiy
N.N.Aey/aiea.-Ee?a, 1998.-N.-54-56.

A?eueei ?.I., Aieei ?.?., Aieeiaa A.I., I?eieuenueea I.?., ?oaee/aiei
A.O. Aioi?o ye iniiaa aeey aeaioiaeaiiy i?ioeae?a?aeiiai e?ea?nueeiai
caniao (aecia/aiiy i?ioei?e?iaii? ae?? a aeine?aeao in vitro ) // Ca.
iaoeiaeo i?aoeue ni?a?ia?oiee?a EIAII ?i. I.E.Ooieea. Aeione 7. Eieaa
2.- Ee?a, 1998.-N.631-642.

10. I?eieuenueeee I.?., I?eieuenueea I.?. Aieaooaaiiy i?e
i?iaaaeaii? iaaeaaia?/iiai aenia?eiaioo //Aenia?eiaioaeueia iaaeaaia?ea
a 20-io noi??//? – Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe??.- Ee?a
“Aa?anaiue” 1996, -N. 64-65.

11. Aeaaiaeaoiee A.I., I?eieuenueea I.?., sseiaaiei A.I. Iia?
i?aeoiaee a ae?aaiinoeoe? aeenaaeoa??ico eeoa/ieea // Oi?ioaaiiy
caei?ia’y ianaeaiiy a Aea?ieoeueeiio ?aeii? i. Ee?aa.- Oace
?aa?iiaeueii? eiioa?aioe??.- Ee?a, 1997.- N.28-29.

12.Oeyoe i?aeaeuaiiy a?ieia?/ii? aeoeaiino? eaeoiaaeoa?eio
/I.?.I?eieuenueea //Aeooaeuei? i?iaeaie i?e?ia?ieia??, ai?aeai?ieia?? oa
i?io?eaeoeee ?ioaeoe?eieo oai?ia: I?aoe? 13- ai c’?caeo Oe?a?inueeiai
iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a oa ia?aceoieia?a ?i.
Ae.E.Caaieioiiai.- Ee?a-A?iieoey, 1996.- N.278.

13.Aeoeai?noue Eaeoiaaeoa??io a eiiieaenieo o?oini?aoe?eieo
eiiiiceoe?yo /I.?.I?eieuenueea, I.A.Oaeeiaa // Aeooaeuei? i?iaeaie
i?e?ia?ieia??, ai?aeai?ieia?? oa i?io?eaeoeee ?ioaeoe?eieo oai?ia:
I?aoe? 13- ai c’?caeo Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a,
ai?aeai?ieia?a oa ia?aceoieia?a ?i. Ae.E.Caaieioiiai.- Ee?a-A?iieoey,
1996.- N.-279.

AIIOAOe?ss

I?eieuenueea I.?. Oaeineiiaeaiiy iaoiaee/ieo i?aeoiae?a uiaei ioe?iee
i?e?ia?ioeaiico eeoa/ieeo oa eiai ei?aeoe??. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 03.00.07 – i?e?ia?ieia?y.- Iaoeiai — aeine?aeiee
?inoeooo i?e?ia?ieia?? ? ?ioiieia?? ?i. ?.?.Ia/i?eiaa, Oa?e?a, 1999.

Aeena?oaoe?th i?enay/aii ieoaiiyi ioe?iee oa ei?aeoe?? i?e?ioei?e
eeoa/ieeo ethaeeie. Aeaia ioe?iea noaio i?e?ioei?e eeoa/ieeo ethaeeie a
iei?oi?e aeieia?/i?e neooaoe?? c ee?i?/ieie i?iyaaie aeenaaeoa??ico
eeoa/ieeo oa o oai?eo c ii?eaie ??ciiai nooiaith. Anoaiiaeaii cieaeaiiy
a?ieia?/ii? aeoeaiino? ?iaeeaaiii? i?e?ioei?e eeoa/ieeo o oaeeo oai?eo.
Oaeineiiaeaia iaoiaeeea ae?aaiinoeee aeenaaeoa??ico eeoa/ieeo. Iaienaii
aeai?eoi ? eiaeia? /enea aeey ?aeaioeo?eaoe?? aioa?iaaeoa??e, yeee noaa
iniiaith aeey ?ic?iaee i?ia?aie eiii’thoa?ii? ia?iaee ?acoeueoao?a
aeine?aeaeaiiy i?e aeenaaeoa??ic?. Iieacaia iiaeeea?noue i?aeaeuaiiy
a?ieia?/ii? aeoeaiino? eiia?oe?eieo ooai?a eaeoiaaoeee ia o?oiiniiaao.
?aeiiaiaeiaaii eiiieaenia aeei?enoaiiy aoa?ioeei– o?oi- ni?aoe?eii?
eiiiiceoe?? aeey ei?aeoe?? i?e?ia?ioeaiico eeoa/ieeo. Iaa?oioiaaii ?
aecia/aii i?ioeiieacaiiy aeey aeei?enoaiiy c iaoith ei?aeoe??
eaiaeeaeiciiai aeenaaeoa??ico eeneioiooai?thth/eo aoa?ioee?a. Iniiai?
?acoeueoaoe i?aoe? ai?iaaaeaeaii? a ?iaioo aaeoa??ieia?/ieo eaai?aoi??e
e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a Oe?a?ie.

Eeth/ia? neiaa: eaeoiaaoeeee, i?e?ia?ioeaiic eeoa/ieeo, aoa?ioee,
ei?aeoe?y aeenaaeoa??ico, o?oiiniiae, ni?aaio.

Ieeieueneay A. E. Niaa?oainoaiaaiea iaoiaee/aneeo iiaeoiaeia e ioeaiea
iee?iaeioeaiica eeoa/ieea e aai ei??aeoeee.- ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/?iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 03.00.07 – iee?iaeieiaey. – Iao/ii-
enneaaeiaaoaeueneee einoeooo iee?iaeieiaee e eiioiiieiaee ei.
E.E.Ia/ieeiaa, Oa?ueeia, 1999.

Aeenna?oaoeey iinayuaia aii?inai ioeaiee e ei??aeoeee iee?iaeioeaiica
eeoa/ieea /aeiaaea. Aeaia ioeaiea ninoiyiey iee?ioei?u eeoa/ieea
/aeiaaea a iuiaoiae yeieiae/aneie neooaoeee n eeeie/aneeie i?iyaeaieyie
aeenaaeoa?eica eeoa/ieea e o aieueiuo n iaeiaaie ?aciie noaiaie.
Iieacaii, /oi i?e ii?aaeaeaiee aaaeouae ?iee ioaeaeueiuo aeaeia
iee?ii?aaieciia a ?acaeoee aeenaaeoa?eica eeoa/ieea ia?yaeo n
eiee/anoaaiiuie iieacaoaeyie iee?iaiiai iaecaaea eeoa/ieea iaiaoiaeeii
ii?aaeaeeoue e niioiioaiea ioaeaeueiuo aai i?aaenoaaeoaeae iaaeaeo
niaie, /oi iiauoaao aeinoiaa?iinoue ?acoeueoaoia iee?iaeieiae/aneie
aeeaaiinoeee aeenaaeoa?eica. Ia iaiaa aaaeiia cia/aiea eiaao
ooieoeeiiaeueiia ninoiyiea eiaeeaaiiie iee?ioei?u eeoa/ieea. Ii?aaeaeaii
nieaeaiea aeieiae/aneie (aioaaiienoe/aneie) aeoeaiinoe yoie ii?iaeueiie
iee?ioei?u eeoa/ieea o oaeeo aieueiuo. I?aaeeiaeaia aeinooiiay aeey
i?aeoe/aneeo eaai?aoi?ee iaoiaeeea aeeaaiinoeee aeenaaeoa?eica eeoa/ieea
/aeiaaea. N oeaeueth iauaeoeaecaoeee ?iee oneiaii-iaoiaaiiuo
yioa?iaaeoa?ee a ?acaeoee aeenaaeoa?eica eeoa/ieea a noaio aai
aaeoa?eieiae/aneie aeeaaiinoeee oeaeaniia?acii aeiiieieoaeueii
aeeth/aoue aeice?iaaiiue aunaa oaeaeee ec ?acaaaeaiey 10 -5 ia
ieanoei/aooth n?aaeo Neiiina, /oi iicaieyao eaaei aeeooa?aioee?iaaoue
eeoa/ioth iaei/eo io oneiaii-iaoiaaiiuo yioa?iaaeoa?ee e nie?auaao n?iee
aeaiie aeeooa?aioeeaoeee. ?aeiiaiaeiaaii ec ?acaaaeaiey 10 -7
aeaeaoue aeice?iaaiiue aunaa ia n?aaeo Yiaei,aeey iaeaa/aiey iiaen/?oa
eiee/anoaa E. coli e i?aaeioa?auaiey iieco/aai ?inoa i?ioay.
Iiaeeoeoee?iaaia n?aaea (I?N-4) aeey auaeaeaiey eaeoiaaoeeee, /oi
iicaieeei i?iecaiaeeoue eiee/anoaaiiue o/ao eaeoiaaoeeee. ?ac?aaioai
aeai?eoi e eiaeiaua /enea aeey ii?aaeaeaiey aeioeie/aneie aeoeaiinoe
yioa?iaaeoa?ee, /oi iineoaeeei iniiaie aeey ?ac?aaioee i?ia?aiiu
eiiiuethoa?iie ia?aaioee ?acoeueoaoia enneaaeiaaiey i?e aeenaaeoa?eica.

Aeey iiauoaiey yoaeoeaiinoe ei??aeoeee aeenaaeoa?eica eeoa/ieea eco/aia
aeiniaianoeiinoue eaeoiaaoeee n ?aciuie oeoiiniiaaie. Iieacaia
aiciiaeiinoue iiauoaiey eiee/anoaa aeecianiiniaiuo eeaoie yoaeioeea e
aeieiae/aneie aeoeaiinoe eiia?/aneeo ooaiiia eaeoiaaoeeee ia ?aciuo
oeoiiniiaao. Iioeiaeueiie oeoiiniiaie yaeyaony ?iiaoea eaea?noaaiiay.
Eco/aia aeiniaianoeiinoue eaeoiaaoeee n ni?aaioii “Yioa?inaaeue”.
Iieacaii, /oi “Yioa?inaaeue” a niane n oeoin?aaeaie ia ieacuaaao
io?eoeaoaeueiiai aeeyiey ia aeieiae/aneoth aeoeaiinoue yoaeioeea-
eaeoiaaoeeee ?aeiiaiaeiaaii eiiieaeniia eniieueciaaiea yoaeioeei- oeoi-
ni?aoeeiiiie eiiiiceoeee aeey yooaeoeaiie ei??aeoeee iee?iaeioeaiica
eeoa/ieea.

Iainiiaaii e ii?aaeaeaii i?ioeaiiieacaiea aeey eniieueciaaiey
eeneioiia?acothueo yoaeioe/aneeo i?aia?aoia n oeaeueth ei??aeoeee
aeenaaeoa?eica iaoneiaeaiiiai i?aeiouanoaaiii a?eaaie ?iaea Candida
spp.. Iniiaiua ?acoeueoaou ?aaiou iaoee i?aeoe/aneia i?eiaiaiea a
iaaeaaiae/aneii i?ioeanna eaoaae?u iee?iaeieiaee e yieaeaieieiaee
Eeaaneie iaaeeoeeineie aeaaeaiee iineaaeeieiiiiai ia?aciaaiey ei.
I.E.Ooieea e aaeoa?eieiae/aneeo eaai?aoi?eyo ea/aaii-i?ioeeaeoe/aneeo
o/?aaeaeaiee Oe?aeiu.

Eeth/aaua neiaa: eaeoiaaoeeeeu, iee?iaeioeaiic eeoa/ieea, yoaeioee,
ei??aeoeey aeenaaeoa?eica, oeoiiniiaa, ni?aaio.

The summary

Nikolska O. Improvement of methodic approaches of an estimation of
intestine microbicenosis and its correction.- Manuscript.

The dissertation on assignment of a scientific degree of the candidate
of medical sciences on a speciality 03.00.07.- microbiology.- Research
institute of microbiology and immunology named I.I.Mechnikov, Kharkov,
1999.

The dissertation is devoted to questions of an estimation and correction
of human intestinal microflora. The evaluation of condition of human
intestinal microflora in the present ecological situation with clinical
signs of disbiosis and at the patients with burn diseas of a different
degree is given. The decrease of biological activiti of normal
intestinal microflora at such patients is established. The technique of
diagnostics of gut disbiosis is advanced. The algorithm and code numbers
for identification of enterobacteriaceae, which steel by a basis for
development of the program of computer processing of results of research
is written at intestinal disbiosis. The opportunity of increase of
biological activity commercial culture of lactobacillus on phyto
nutrient medium is shown. Complex use of eubiotic-phyto-sorbtion
composition for correction of disbiosis of gut is recommended. The
reasonable indications and the contra-indications for application of
acid-forming eubiotics are determined in order to correct the disbiosis
condisioned by Candida spp. The basic results of research are introduced
into work of pedagogical process of faculty of microbiology Kiev medical
academy of postgraduate training and bacteriological laboratories of
medical establishments of Ukraine.

Key words: lactobacillus, intestinal microflora, eubiotic, correction of
intestinal disbiosis, phyto nutrient medium, sorbent.

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