1

EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO

AAIAOIEIA?? OA IA?AEEAAIIss E?IA?

IIC OE?A?IE

NOAAETHE ANAAIEIAe AIEIAeEIE?IAE*

OAeE 616.36-099: 615.366.15

O?AINOOC?EII-AeAOIENEEAOe?EIA OA?AI?ss

NEIAe?IIO AIAeIOIENEEICO

I?E CAOAI?THAAIIssO IA*?IEE

C CANOINOAAIIssI A?INIAOeEO?*IEO AAIINI?AAIO?A

14.01.31-Aaiaoieia?y oa o?ainooc?ieia?y

?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo? aaiaoieia??
oa ia?aeeaaiiy e?ia? IIC Oe?a?ie.

Iaoeiaee ea??aiee -aeieoi? iaaee/ieo iaoe

NOA?EEIA Aiaoie?e Aieiaeeie?iae/,

caa?aeoaa/ a?aeae?eaiiyi ee?i?/ii? o?ainooc?ieia?? oa ?ioaineaii?
oa?ai?? EIAe? aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a?ie,
i.Ee?aIo?oe?ei? iiiiaioe -Aeieoi? iaaee/ieo iaoe

OEI*AIEI Aiaoie?e Na?a?eiae/,

caa?aeoaa/ eaai?aoi???th o?aeoe?iioaaiiy ieacie e?ia? EIAe? aaiaoieia??
oa ia?aeeaaiiy e?ia? IIC Oe?a?ie, i.Ee?a
-aeieoi? iaaee/ieo iaoe, i?ioani?,

COAEIA A?eoi? ?aaiiae/,

caa?aeoaa/ a?aeae?eaiiyi aianoac?ieia?? oa ?ioaineaii? oa?ai?? ?inoeoooo
ee?i?/ii? oa aenia?eiaioaeueii? o??o?a?? AII Oe?a?ie,i.Ee?aI?ia?aeia
onoaiiaa -?inoeooo aenia?eiaioaeueii? iaoieia??, iieieia?? oa
?aae?ia?ieia?? ?i. ?.?. Eaaaoeueeiai IAI Oe?a?ie, a?aeae?e ooo/ieo
i?aai?a oa iaaee/ii? a?ioaoiieia??, i.Ee?a

Caoeno a?aeaoaeaoueny “20” aeiaoiy 1999 ?. i 14 aiaeei? 30 oaeeei ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.612.01 a Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC
Oe?a?ie ( 254060, i. Ee?a, aoe. I.Aa?e?inueeiai, 12)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai IAe?
aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a?ie.

Aaoi?aoa?ao ?ic?neaiee “ 27 na?iiy ” 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee EII?NA?AIEI
A.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. A e?eoaaeuei?e i?aeoeoe? aeoaea /anoi
eiaeiiio e?ea?th, iacaeaaeii a?ae eiai oaoo , aeiaiaeeoueny
cono??/aoenue c oaeei oneeaaeiaiiyi ia?aa?ao oai?ia ye neiae?ii
aiaeioieneeico ( E.A. I?i/oe, 1972; ?.I. Aaiaea, 1989; E.O.Aaneeueaa
,1995; A.A.Noa?eeia ,1992). Ii?ooaiiy ooieoe?? ia/?iee iiaea aooe ye
i?e/eiith oae ? iane?aeeii aiaeioieneeico. Aieiaieie iiiaioaie ?icaeoeo
ia/?ieiai? iaaeinoaoiino? ? ciaioaiiy e?eueeino? ooieoe?iiaeueii
iiaiioe?iieo aaiaoioeeo?a ca ?aooiie oeeoiiae?ico oa oeeoie?co ( O.A.
Aaaoeia, 1990). Iane?aeeii oeeoie?co ? ooai?aiiy aooiaioeo?e aei
eiiiiiaio?a ee?oeiiiai yae?a, i?oioiiae??e , aeaiaio?a ee?oeiii?
iaia?aie, caione iaoai?cio aooi?ioiii? aa?an?? c aoi?eiiith
ooeiaeaeath/ith ae??th ( O.A. Aaiieia; 1985). Aeoeaaoe?y i?ioaie?oe/ii?
nenoaie, iaeiie/aiiy a?ieia?/iiaeoeaieo ?a/iaei oa oiene/ieo noanoaioe?e
i?ecaiaeeoue aei iiaeaeueoiai i?aeaeuaiiy ??aiy nae?aoe?? aiaeia?/ieo
?a/iaei oa i?enei?aiiy ?icaeoeo aeaeiiiainaoe?? c aaia?ae?caoe??th
neiae?iio.

?icaeoie iie?i?aaiii? iaaeinoaoiino? i?e neiae?ii? aiaeioieneeico
aeiaaa? aeaaaeaiiai i?aeoiaeo aei ioe?iee noaio oai?iai oa aeai?o
iaoiae?a oa?aiaaoe/iiai aieeao. No/aniee i?aeo?ae aei ?ioaineaii?
oa?ai?? neiae?iio aiaeioienai?? oa?aeoa?eco?oueny eiiieaeniei
ae??oaiiyi,ui ia?aaeaa/a? aieea ia an? iaoiaaiaoe/i? eaiee aeaiiiai
i?ioeano, a yeiio ii?aeiothoueny ye o?aaeeoe?ei? oa?aiaaoe/i? caoiaee,
oae ? canoinoaaiiy iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? (aaii- oa
ieaciini?aoe??, e?eoaaeueiiai ieaciaoa?aco). Iiyaa a i?aeoeoe?
aeno?aei?ii?aeueii? aeaoieneeaoe?? ni?aaio?a a?iniaoeeo?/ii?
iai?aaeaii? ae?? cia/ii ?icoe?th? iiaeeeaino? oa?aiaaoe/iiai aieeao ia
aiaeioieneeic .

I?ioa a e?oa?aoo?ieo aeaea?aeao ia aeinoaoiuei aena?oeaii ieoaiiy
eiiieaeniiai i?aeoiaeo aei oa?ai?? aiaeioieneeico, c o?aooaaiiyi an?o
i?iya?a iie?i?aaiii? iaaeinoaoiino?. Ia ?ic?iaeaii ?aeeio nenoaio
ioe?iee nooiaiy oyaeeino? noaio iaoe??ioa c neiae?iiii aiaeioieneeico.
Ui noino?oueny oa?ai?? aiaeioieneeico, oi a oeueiio ieoaii? , cie?aia,
ia noai?aii nenoaio iieacaiue oa i?ioeiieacaiue aei canoinoaaiiy ??cieo
iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? o oai?eo c oyaeeei oa
e?eoe/iei nooiaiai aiaeioieneeico. Caeeoathoueny i?iaeaiaoe/ieie
ieoaiiy aianoac?ieia?/iiai caaacia/aiiy i?ioeaaeo? aeno?aei?ii?aeueii?
aeaoieneeaoe?? oa i?io?eaeoeee iiaeeeaeo oneeaaeiaiue.

Aeaiia aeena?oaoe?eia ?iaioa iieeeeaia c?iaeoe aianie o a/aiiy i?i
e?eoaaiiy oeueiai neeaaeiiai, iaaacia/iiai aeey aeeooy noaio.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie. Oaia ?iaioe iia’ycaia c
ieaiiaith ?iaioith Ee?anueeiai IAe? Aaiaoieia?? oa ia?aeeaaiiy e?ia?
IIC Oe?a?ie oa ? ?icae?eii IAe? ”?ic?iaea i?ia?aie aooiaaiio?ainooc?eii?
oa?ai?? c canoinoaaiiyi ??cieo oei?a ni?aoe?eiiai iaoa??aeo oa OOI e?ia?
aeey e?eoaaiiy oai?eo o??o?a?/iiai, aaiaoieia?/iiai i?io?eth oa c
caoai?thaaiiyie ia/?iee”. OAeE 615.366.15., ? aea?ae?a?no?aoe??
019400017342, oeo? OeO 463.Oaia aeena?oaoe?? caoaa?aeaeaia ia can?aeaii?
A/aii? ?aaee EIAe? AIE IIC Oe?a?ie (i?ioieie ? 10 a?ae 0.5.12.1995).

Iaoa ?iaioe. ?icoe?aiiy iiaeeeainoae oa?aiaaoe/iiai aieeao ia neiae?ii
aiaeioieneeico o oai?eo c caoai?thaaiiyie ia/?iee oeyoii ?ic?iaee oa
ai?iaaaeaeaiiy a e?eoaaeueio i?aeoeeo noai o?ainooc?eii-
aeaoieneeaoe?eii? oa?ai?? c canoinoaaiiyi iaoiae?a aeno?aei?ii?aeueii?
aeaoieneeaoe??, cie?aia aaii- oa ieaciini?aoe?? ia a?iniaoeeo?/ieo
ni?aaioao.

Caaaeaiiy aeine?aeaeaiiy:

1. ?ic?iaeoe e?eoa??? ioe?iee o?aaeaieo i?aai?a oa nenoai i?e
aiaeioieneeic? oa aecia/aiiy nooiaiy oyaeeino? noaio iaoe??io?a
caeaaeii a?ae i?iya?a iie?i?aaiii? iaaeinoaoiino?.

2. Aea/eoe iniaeeaino? o?aaeaiiy i?aai?a oa nenoai o oai?eo c
iaoieia??th aaiaoia?e?a?ii? nenoaie c neiae?iiii aiaeioieneeico.

3. Aecia/eoe e?eoa??? eaai?aoi?ii? oa ee?i?/ii? aoaeoeaiino? ni?aoe?eii?
aeaoieneeaoe?? ia ??cieo oeiao ni?aaio?a, a oaeiae i?iaanoe
ii??aiyeueiee aiae?c aoaeoeaiino? iaoiae?a aeno?aei?ii?aeueii?
aeaoieneeaoe?? oa o?aaeeoe?eieo oa?aiaaoe/ieo caoiae?a i?e aiaeioienai??
ui yaeeany iane?aeeii caoai?thaaiue ia/?iee.

4. ?ic?iaeoe iieacaiiy oa i?ioeiieacaiiy aei i?iaaaeaiiy
aeno?aei?ii?aeueii? aeaoieneeaoe?? o oai?eo c neiae?iiii aiaeioieneeico.

Iaoeiaa iiaecia.

?ic?iaeaii neiae?iiaeueio iinenoaiio noaio ioe?iee nooiaiy oyaeeino?
neiae?iio aiaeioieneeico.

Anoaiiaeaii caeaaei?noue i?iya?a iie?i?aaiii? iaaeinoaoiino? o oai?eo c
iaoieia??th aaiaoi-a?e?a?ii? nenoaie a?ae nooiaiy oyaeeino?.

Aeine?aeaeaii aaeni?aoth/o aeanoea?noue ??cieo oei?a ni?aaio?a (ye
iao?e/ieo, oae ? a?iniaoeeo?/ieo, AeIE-i?noy/eo ni?aaio?a ) a?aeiinii
caaaeueieo iaoaaie?o?a oa ia?ea??a aiaeioienai?? a noaiaeiaeo
aeine?aeaeaiiyo. I?iaaaeaii aiae?c eaai?aoi?ii? oa ee?i?/ii?
aoaeoeaiino? iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? a ii??aiyii? c
o?aaeeoe?eiith oa?ai??th aiaeioienai?? o oai?eo c caoai?thaaiiyie
aaiaoi-a?e?a?ii? nenoaie.

Aia?oa ?ic?iaeaii i?ia?aio aeai?o iaoiaeo aeno?aei?ii?aeueii?
aeaoieneeaoe?? a eiiieaen? oa?aiaaoe/eo caoiae?a i?e neiae?ii?
aiaeioieneeico a caeaaeiino? a?ae nooiaiy oyaeeino? oa i?iya?a
iie?i?aaiii? iaaeinoaoiino?.

I?aeoe/ia cia/aiiy ?iaioe . ?ic?iaeaia noaia iinenoaiii? ioe?iee noaio
iaoe??ioa aeicaiey? i?iaiaeeoe iiaiee, uiaeaiiee iii?oi??ia ci?i o
i?aai?ci?, aecia/aoe iaea?eueo o?aaeai? i?aaie oa nenoaie, aaeeaath/e
caoiae?a aei e?eoaaiiy oa i?io?eaeoeee iiaeeeaeo oneeaaeiaiue.

Cai?iiiiiaaia nenoaia aianoac?ieia?/iiai caaacia/aiiy, caoiaee ii
i?io?eaeoeoe? ??ciiai ?iaeo oneeaaeiaiue, ?ic?iaeai? noaie
aaia?ei?caoe?? oa iinoia?ooc?eiiai aieeao ia aaiinoac c aeei?enoaiiyi
iecueeiiieaeoey?ieo aaia?ei?a (“O?aeneia?ei”), ye? aeicaieythoue cia/ii
?icoe?eoe iaae? aeei?enoaiiy aeno?aei?ii?aeueii? aeaoieneeaoe??.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo. ?acoeueoaoe
aeine?aeaeaiue oa ?ic?iaeai? iaoiaee/i? ?aeiiaiaeaoe?? ai?iaaaeaeaii a
i?aeoeeo a?aeae?eaiue ?ioaineaii? oa?ai?? oa niiaoe/ieo a?aeae?eaiue
iaaee/ieo caeeaae?a nenoaie IAN a Oiaeueieoeuee?e oa *a?i?a?anuee?e
iaeanoyo, 411 ie?oaeiiai ee?i?/iiai aini?oaey II Oe?a?ie a i. Iaean?,
ee?i?/ii? e?ea?i? ? 9 i?noa Ee?aa.

Ai?iaaoe?y ?iaioe . Iaoa??aee aeena?oaoe?? aeiiia?aeaeeny ia iaoeia?e
eiioa?aioe?? “A?aeaeaeai? iane?aeee ii?ii?iaiiy a ?ioii?e oa
aaiiiiaoe/i?e nenoaiao”( Ee?a,1996), iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeooaeuei? ieoaiiy iaaeeoeeie”, i?enay/ai?e 30-??//th OeA IAN Oe?a?ie
(Ee?a, 1997 ?.).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 9 iaoeiaeo ?ia?o,
c yeeo 4 noaoo? a aeo?iaeao, ui aoiaeyoue aei caoaa?aeaeaiiai AAE
Oe?a?ie ia?ae?eo iaoeiaeo aeaeaiue, a yeeo iiaeooue ioae?eoaaoenue
iniiai? ?acoeueoaoe aeena?oaoe?eieo ?ia?o, oa aeaeaii iaoiaee/i?
?aeiiaiaeaoe?? “ Iaoiaee ?ioiini?aoe?? a ?ioaineai?e oa?ai?? neiae?iio
aiaeioieneeico”( 1996).

No?oeoo?a ? ianya aeena?oaoe?? . Aeena?oaoe?y aeeeaaeaia ia 141
noi??ieao iaoeiiieniiai oaenoo, ?ethno?iaaia 36 oaaeeoeyie oa 8
?enoieaie. Neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, aeaae,
i?enay/aii? iaoa??aeai oa iaoiaeai aeine?aeaeaiue, /ioe?ueio aeaa
aeanieo niinoa?aaeaiue, iaaiai?aiiy io?eiaieo ?acoeueoao?a,
aeniiae?a , i?aeoe/ieo ?aeiiaiaeaoe?e. Iieaae/ee e?oa?aoo?e ai?uo? 264
aeaea?aea, na?aae yeeo 96 a?o/eciyieo oa 168 ca?oa?aeieo.

Aeaeea?aoe?y iniaenoiai aianeo aeena?oaioa a ?ic?iaeo iaoeiaeo
?acoeueoao?a. Aaoi?ii iniaenoi i?iaaaeaii ee?i?/ia ianoaaeaiiy
oa e?eoaaiiy 149 oai?eo c iaoieia??th aaiaoi-a?e?a?ii? nenoaie, ui
oneeaaeieeanue neiae?iiii aiaeioieneeico, i?iaiae?ciaaii i?iyae
iie?i?aaiii? iaaeinoaoiino?. ?ic?iaeaii noaio ioe?iee nooiaiy oyaeeino?
neiae?iio aiaeioieneeico.

I?e e?eoaaii? oai?eo c ia/?ieiaith iaaeinoaoi?noth i?iaaaeaii 50 naain?a
aaiini?aoe?? c aeei?enoaiiyi ni?aaioo AOAeN, 53 naaine e?eoaaeueiiai
ieaciaoa?aco (c ieo 13 iniaenoi , ?aooa – o a?aeae?eaii? ee?i?/ii?
o?ainooc?ieia?? oa ?ioaineaii? oa?ai?? EIAe? AIE ( caa.a?aeae?eaiiyi
ae.i.i. A.A.Noa?eeia), 10 naain?a ieaciini?aoe?? c aeei?enoaiiyi
ni?aaioo AOAeN. I?inoaaeaii ia?aa?a neiae?iio aiaeioieneeico a
caeaaeiino? a?ae oa?aiaaoe/ii? oaeoeee, i?iaaaeaii ii??aiyeueiee aiae?c
ee?i?/ii? oa eaai?aoi?ii? aoaeoeaiino? ??cieo i?ia?ai ?ioaineaii?
oa?ai?? c canoinoaaiiyi iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? o
oai?eo c i?iyaaie ia/?ieiai? iaaeinoaoiino?.

?ic?iaeaii iieacaiiy oa i?ioeiieacaiiy aei i?iaaaeaiiy
aeno?aei?ii?aeueii? aeaoieneeaoe?? o oai?eo c neiae?iiii aiaeioieneeico.
?ic?iaeaii oa ai?iaaaeaeaii a i?aeoeeo aeai?eoi aeai?o o?ainooc?eii-
aeaoieneeaoe?eii? oa?ai?? neiae?iio aiaeioieneeico c aeei?enoaiiyi
iaoiae?a AEAe.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy.

A i?ioean? ?iaioe aoei i?iaaaeaii aiae?c ee?i?/ieo oa eaai?aoi?ieo
iieaciee?a o 149 oai?eo, ui i?ioiaeeee e?eoaaiiy a aini?oae? AO IAN
Oe?a?ie a i.Ee?a? oa Oe?EE Oaa/aie?anueeiai ?aeiio i.Ee?aa a ia??iae c
1994 ii 1997 ??e.

An? oai?? aoee ?iciiae?eai? ia a?oie ca aeaeaie oa?ai??:

· Aeine?aeia a?oia 1: caaaeueia oa?ai?y + aaii?ioiini?aoe?y ia ni?aaio?
AOAeN,

· Aeine?aeia a?oia 2: caaaeueia oa?ai?y + ieaciaoa?ac (i?aea?oio c 10
oai?eo neeaaeaee iaoe??ioe c, yeei aoei i?iaaaeaii ieaciini?aoe?th ia
ni?aaio? AOAeN),

· Eiio?ieueia a?oia: o?aaeeoe?eia oa?ai?y ia/?ieiai? iaaeinoaoiino? aac
canoinoaaiiy aeno?aei?ii?aeueii? aeaoieneeaoe??.

Ca /an aeine?aeaeaiiy aoei i?iaaaeaii aaii?ioiini?aoe?e ia ni?aaio?
AOAeN -50, ieaciaoa?ac?a — 53, ieaciini?aoe?e ia ni?aaio?
AOAeN- 10.

Eiio?ieueio a?oio neeaee niinoa?aaeaiiy ca 36 oai?eie.

Aaciina?aaeiueith i?e/eiith ?icaeoeo neiae?iio aiaeioieneeico o oai?eo
c ia/?ieiaith iaaeinoaoi?noth aoee:

· aino?ee oiene/iee aaiaoeo ( ca i?aeia?iaeiith noaoenoe/iith
eeaneo?eaoe??th oai?ia oa nii??aeiaieo i?iaeai caei?ia’y – MKX-10 –
oiene/ia oai?iaa ia/?iee),

· o?ii?/iee aeoeaiee aaiaoeo a noaae?? caaino?aiiy ( A.N. Eia?iia,
TH.A. Aeie,1987),

· o?ii?/iee ia?nenooth/ee aaiaoeo ( A.N. Eia?iia, TH.A. Aeie,
1987),oee?ic ia/?iee ( a oeth a?oio oa?eoee oai?? c iae?i- oa
i?e?iiiaeoey?iei oee?icii, ci?oaiei oee?icii ia/?iee — ca i?aeia?iaeiith
eeaneo?eaoe??th 1974 ?ieo)

Oaaeeoey 1 –?iciiae?e oai?eo ca iicieia?/ieie a?oiaie

Iicieia?yA?oia 1A?oia 2I?aea?oia

INEiio?. A?oiaAnueiaiAino?ee

Oiene/iee aaiaoeo119-727O?ii?/iee

aeoeaiee aaiaoeo11172737O?ii?/iee ia?nenooth/ee aaiaoeo171661150Oee?ic
ia/?iee111121135Anueiai50531036149Ee?i?/i? oa a?io?i?/i? aeine?aeaeaiiy
e?ia? i?iaiaeeeenue a eaai?aoi??yo aini?oaeth AO IAN Oe?a?ie a i.Ee?a?,
9 ee?i?/ii? e?ea?i? i.Ee?aa, a?aeae?eaiiy ee?i?/ii? o?ainooc?ieia?? oa
?ioaineaii? oa?ai?? EIAe? AIE ( caa.a?aeae?eaiiyi – ae.i.i.
A.A.Noa?eeia), ?ioiieia?/i? aeine?aeaeaiiy i?iaaaeai? a eaai?aoi???
IOe?I AII Oe?a?ie (ia aac? aini?oaeth AO IAN Oe?a?ie a i. Ee?a?) ,
ea??aiee – ae.i.i. Ieoaeeianueea A.A.) oa eaai?aoi??? ?inoeoooo
oo?c?ao??? oa ioeueiiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie (
aeeiiaii e.i.i. Oaaei?oe I.?.).

E?eoa??yie ooieoe?iiaeueiiai noaio ia/?iee aecia/aeeny a?io?i?/i?
iieacieee e?ia?: eiioeaio?aoe?y caaaeueiiai a?eeo (?ao?aeoiiao??y oa
a?o?aoiaa ?aaeoe?y), o?aeoe?? a?eeo iaoiaeith aeaeoi?ioi?aco ia aoeaoao?
oeaetheice, a?e??oa?i oa eiai o?aeoe??-niaeo?ioioiiao?e/ii ii
ae?aci-?aaeoe??, aeoeai?noue aeai?iai?iio?ainoa?ace — oi?o?eiaaiith
ae?i?o?ioaiiea?ae?ac?iiaith iaoiaeith (ii ?aeoiaio-O?aieaeth),
eiioeaio?aoe?th na/iaeie aecia/aee eiei?eiao?e/iith iaoiaeith c
ae?aoeeeiiiiieneiii, e?aaoei?io- ii oaaoi?e ?aaeoe?? ssooa (iaoiaea
Iiooa?a) .

Iieacieee ??aith aiaeioienai?? aecia/aeeny ianooiieie iaoiaeaie:

oiene/i?noue ne?iaaoee aei eaeeioeeo?a (iaoiaeii ?ioiieaeeie?co ca
Iaioeeiaei A.A.(1987), ai?no na?aaeiuei- oa aaeeeiiieaeoey?ieo iaioeae?a
iaoiaei inaaeaeaiiy noeueoaoii aiii?th niaeo?ioioiiao?e/ii i?e aeiaaeei?
oaee? 280 ii.

I?e aeine?aeaeaii? ?ioiieia?/ieo iieaciee?a o ia?o?e a?oi? (AOAeN)
?ioiieia?/ia ianoaaeaiiy oai?eo i?iaiaeeeinue ia ii/aoeo e?eoaaiiy , ia
ae?oao oa 10 aeiao i?ney i?iaaaeaiiy aaiini?aoe??. A eiio?ieuei?e
a?oi? ianoaaeaiiy i?iaiaeeeenue ia 1 , 3 oa 10 aeiao e?eoaaiiy. Aeey
oa?aeoa?enoeee O-nenoaie ?ioi?oaoo aecia/aee a?aeiinio e?euee?noue
A-?icaoeiooai?thth/eo ee?oei (A-?OE) ca Bach I. ET AL. ( 1969),
noaiiioeyoe?eiee neeaae O-e?ioioeeo?a ca ai?noii oaio?e?i?acenoaioieo
(OO?-) ? oaio?e?i/ooeeaeo (OO*-) ?icaoeiooai?thth/eo ee?oei ca Limatibul
S. (1987). A-nenoaio ?ioi?oaoo ioe?ithaaee ca ??aiai
AAN-?icaoeiooai?aiiy e?ioioeeo?a e?ia? ca *a?aae??aei A.I., (1976).
Eiioeaio?aoe?? ne?iaaoieo Ig A,M,G aecia/aee ca Mancini (1977), ai?no
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) – ca Hashkova V., (1977). Ca
eiio?ieue i?e oeeo aeine?aeaeaiiyo aaaaeaeeny ?acoeueoaoe ianoaaeaiiy
46 aeiii??a, ui aaaaeaeenue caei?iaeie.

Aeey i?iaaaeaiiy aaiini?aoe?? aeei?enoiaoaaeenue aia?aoe ANA — 01, OAAA,
ia?ooc?ei? aeiee aia?ao?a ooo/iiai e?iaiia?ao ae?iaieoeoaa i?aei?e?inoa
Oe?a?ie oa NIA. I?e i?iaaaeaii? aaiiia?ooc?? aeei?enoiaoaaeenue
noaiaea?oi? iaa?no?ae? aei aia?aoo “Ooo/ia ie?ea”. Aeey i?iaaaeaiiy
ieaciini?aoe?? aeei?enoiaoaaany aia?ao a?aa?oaoe?eiiai ieaciaoa?aco
IO-0,5 a ia’?aeiai?e nenoai? c ia?ooc?eiei aeieii. I?e oeueiio
aeei?enoiaoaaeenue nenoaia iaa?no?aeae aeey ieaciaoa?aco oa iaa?no?ae?
aeey aaiini?aoe??. Ieaciaoa?ac i?iaiaeeany ye ia aia?ao? IO-0,5
(aacia?a?aiee ), oae ? ia oeaio?eooaao c aeei?enoaiiyi ieanoeeaoii?
oa?e oeio “Aaiaeii”. A noaiaeiaeo aeine?aeaeaiiyo aeei?enoiaoaaany
aaoiiaoe/iee ci?ooaa/ Nontraves autodilutor (Oaaeoea??y).

Ni?aaioe AOAeN (aaiini?aaio oaea?iaeiue, AeIE-niaea?aeauee,
noa?e/aneee), u?euei?noue ii? ii aaicieo 0,9 ni3 /a, aeoeaia iiaa?oiy
ii? 1100 i2a, c o?eniaaiith iaoeaiith o?ioniith AeIE (IA-9000 ED, ai?no
1-5iaa ) ( aeica?e ia ee?i?/ia canoinoaaiiy ? 135 a?ae 21.04.1992 ?ieo,
iiceoe?y 184 iaeaco IIC N?N?, OO 88O 107.002-91.) aeei?enoiaoaaeenueny
o noaiaea?oieo neeyieo oeaeiiao ii 100 oa 400 ie, i?e oeueiio
canoiniaoaaeanue u?eeiia ia?ooc?eia ianaaeea IIAN. Ni?aaio AOAeN
(aieieienoee aoaeaoeaaee, AeIE-i?noy/ee, ia iniia? aoaeaoeaai? oeaieie
“Aei?i?i”), u?euei?noue ii? ca aaicieii 1-2 ni3a, aeoeaia iiaa?oiy
2200i2a aeei?enoiaoaaany o iie?ia?ieo eieiieao, ui aaciina?aaeiuei
i?aeeeth/aeenue aei ia?ooc?eiiai eiioo?o (?a?no?aoe?y Eii?oaoa c iiai?
iaaee/ii? oaoi?ee IIC Oe?a?ie, i?ioieie ?5 a?ae 31.05.1995 ?ieo).

Ni?aaioe ?ic?iaeaii oa aeaioiaeaii a ?inoeooo? aenia?eiaioaeueii?
iaoieia??, iieieia?? oa ?aae?ia?ieia?? ?i. ?.?. Eaaaoeueeiai IAI
Oe?a?ie. Ni?aaio NEI aeaioiaeaii i?aei?e?inoaii “Aeini?a”, Ee?a,
Oe?a?ia.

Io?eiai? oeeo?ia? aeai? ii?aoeueiaai? noaoenoe/ii c aeei?enoaiiyi
e?eoa??th Nouethaeaioa (Eai?inueeee E.N.,1964) oa ca iaoiaeii eooiaiai
ia?aoai?aiiy O?oa?a (Aoaea? A.A.,1978). ??cieoeth i?ae aaee/eiaie , ui
ii??aithaaeenue, aaaaeaee a??ia?aeiith i?e p < 0,05. Noaoenoe/ia ia?iaea, iiaoaeiaa a?ao?e?a, oaaeeoeue oa ae?aa?ai i?iaaaeaia ca aeiiiiiaith i?ia?aie Microsoft Exel ia IAII ?AI ?NAO. ?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. ?icaeoie iie?i?aaiii? iaaeinoaoiino? i?e neiae?ii? aiaeioieneeico aeiaaa? aeaaaeaiiai i?aeoiaeo aei ioe?iee noaio oai?iai oa aecia/aiiy nooiaiy oyaeeino?, aeey /iai aoei ?ic?iaeaii nenoaio e?eoa???a o?aaeaiiy i?aai?a oa nenoai (oaae.2). Oaaeeoey 2- Nenoaia e?eoa???a ioe?iee iie?i?aaiii? iaaeinoaoiino? Cooi?iue o?aaeaiiy AaeeEaaeee 0Na?aaei?e 2Oyaeeee 4E?eoe/iee 6Na?oeaai-noaeeiia nenoaia:Oieiaee ?iaeaen (a?aeiioaiiy AO /*CC ) OeAO ii aiaei.no. Ii?ooaiiy ?eoio Ii?ooaiiy i?ia?aeiino? >1,5

60-120

a?aenooi?

a?aenooi?1,49 – 1,2

<60 >120

ie?ai? aen.n?noiee

A-Vaeieaaea

? nooiaiy1,19-0,7

<40 >160

a?oiia?

aen.n?noiee,

A-V aeieaaea

?? nooiaiy<0,69 <20 >200

neeaaei? ii?ooaiiy

?eoio oa i?ia?aeiino?Aeeoaeueia nenoaia:Oeeaiic

*anoioa aeeoaiiy

Ee?i?/i? i?iyaeIaia?

20-28

iaia?Eaaeee

29 –32

a?iio?oCia/iee

33-40

iiaaiii?yOioaeueiee

> 40

?AeNIa?aiaa nenoaia:Aioeaoaeiiao?y0-1234Ie?eiaa iaaeinoaoi?noue:Ae?o?ac

ieeaaiae.

E?aao?i?i

iiieuee

Na/iaeia

ieiieuee0,7-1

<0,19 <100,4-0,6 <0,701 <170,3-0,2 <1,055 <30<0,2 >1,055

>30Ia/?ieiaa iaaeinoaoi?noue:A?e??oa?i

ieiieuee<2626-5050-100>101Aiai?y:Aaiiaeia?i ( ae)

Aaiaoie?eo>110

>0,490-110

0,39-0,260-89

0,19 – 0,1<60 <0,09Ii?ooaiiy aaiinoaco:O?iiaioeeoe o109e IO? (%) Ee?i?/i? i?iyae130-150 60-70 iaia?100-129 40-59 iaoao??60-99 30-39 aaii?aa??<60 <30 OAN Iinoaaeaia caaea/a ioe?iee nooiaiy oyaeeino? neiae?iio aiaeioieneeico ae??ooaaeanue oeyoii aei??thaaiiy o iaoe?aioa iieaciee?a aaiiaeeiai?ee, ioe?iee noaio aeeoaeueii? oa ia?aiai? nenoaie, ioe?iee ee?i?/ieo oa a?io?i?/ieo aiae?c?a e?ia?, iiaiaeeiiiai ae?o?aco, iieaciee?a cai?ooth/i? nenoaie e?ia?, i?e yeiio eiaeai iieaciee ioe?ith?oueny iaaiith e?euee?noth aae?a (a?aeiia?aeii aei nooiaiy eiai a?aeoeeaiiy a?ae ii?ie). I?ney oeueiai i?iaiaeeoueny ?ic?aooiie na?aaeiueiai a?eoiaoe/iiai a?ae noie aae?a ii eiaei?e nenoai?. Nooi?iue oyaeeino? neiae?iio aiaeioieneeico aecia/a?oueny a?aeiia?aeii aei noie na?aaeiueia?eoiaoe/ieo aae?a ii nenoaiao oa ioe?ith?oueny ye eaaeee, na?aaeiueiai nooiaiy, oyaeeee /e e?eoe/iee. Nooi?iue oyaeeino? neiae?iio aiaeioieneeico aecia/a?oueny ye eaaeee i?e noi? iieaciee?a a?ae 0 aei 10 aae?a, na?aaei?e - a?ae 10,1 aei 20 aae?a, oyaeeee – a?ae 20,1 aei 30 aae?a, e?eoe/iee – a?ae 30,1 aei 42 aae?a. Aiae?c o?aaeaiiy nenoai oa i?aai?a o iaoe??io?a c caoai?thaaiiyie aaiaoi-a?e?a?ii? nenoaie i?e ?icaeoeo aiaeioieneeico iieacaa iaai? caeiiii??iino? caeaaeiino? noaio a?ae o?aaeaiiy ie?aieo nenoai. Neiae?iiaeuei? caeaaeiino? ii a?oiao ca oyaee?noth noaio iaaaaeaii ia ?en. 1. picscalex100010009000003691f00000900350000000000050000000902000000000500 00000102ffffff000400000004010d000400000002010200050000000c02b20127020300 00001e00040000002701ffff030000001e00040000002701ffff050000000b0200000000 030000001e00050000000102ffffff0005000000090200000000040000002701ffff0300 00001e00050000000102ffffff0005000000090200000000070000001604b20127020000 000009000000fa02050000000000000000002200040000002d01000007000000fc020000 ffffff000000040000002d010100050000000902ffffff00050000000102000000000400 000004010d000400000002010200070000001b04af0123020500050009000000fa020000 00000000000000002200040000002d010200040000002d010100040000002701ffff0300 00001e00040000002d010100040000002d01000005000000010200000000050000000902 ffffff00070000001604b201270200000000070000001504a20120023201900104000000 2d010200040000002d010100040000002701ffff030000001e00040000002d0101000400 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00002d010100040000002d010400040000002701ffff030000001e00040000002d010000 040000002d010100040000002d010800050000000102ffffff0005000000090200000000 070000001604b201270200000000040000002d010500040000002d01020004000000f001 0800040000002701ffff050000000c02b2012702030000001e00050000000102ffffff00 05000000090200000000040000002701ffff050000000b0200000000030000001e000500 00000102ffffff0005000000090200000000040000002701ffff03000000000000000000 000000000000000000000000000000000000000000000000000000000000 ?en.1.Nenoaii? o?aaeaiiy i?e neiae?ii? aiaeioieneeico o iaoe??io?a c caoai?thaaiiyie aaiaoi-a?e?a?ii? nenoaie. C iaaaaeaii? ae?aa?aie aeaeii, ui neiae?ii aiaeioieneeico ae?enii ? i?e/eiith iie?i?aaiii? iaaeinoaoiino?, ine?eueee nooi?iue oyaeeino? noaio oai?iai ciaoiaeeoueny a i?yi?e caeaaeiino? a?ae nooiaiy o?aaeaiiy nenoai. sseui o a?oi? oai?eo c eaaeei aiaeioieneeicii cono??/a?oueny eeoa ii?ooaiiy ooieoe?? ia/?iee (Ii-ia/?ieiaa iaaeinoaoi?noue) oa iacia/i? ci?ie a na?oeaai-noaeeii?e nenoai? (NNN) ca ?aooiie oao?ea?ae??, oi aaea i?e na?aaei?e oyaeeino? oai?eo ia 1-1,5 ioieo?a ci?iththoueny iieacieee ii ie?eia?e iaaeinoaoiino? (Ii), aiai?caoe?? (A), ii?ooaiiyo aaiinoaco (A). Ii?ooaiiy ia?aiai? nenoaie (IN) aeieeathoue aaea i?e na?aaeiueiio nooiai? oyaeeino? ? ci?iththoueny eeoa ia 1 ioieo aei ?icaeoeo e?eoe/iiai noaio, c?inoath/e iae?aco ia 2 ioieoe. Ii?ooaiiy aaiinoaco oa aiai?caoe?y i?aeoe/ii iaeiaeia? i?e na?aaeiueiio oa oyaeeiio nooiai? o?aaeaiiy oa c?inoathoue ia 1,8 ioieo?a i?e e?eoe/iiio noai?, ui iae/ano?oa aoaa? aeeeeeaii ?icaeoeii AeAC (o?iiai-aaii?aa?/iiai) neiae?iio. Oaeei /eiii, ua ?ac aeiaaaeaii, ui neiae?ii aiaeioieneeico ae?enii ? a??ciei oneeaaeiaiiyi ia?aa?ao caoai?thaaiue aaiaoi-a?e?a?ii? nenoaie, ui noi?iaiaeaeo?oueny ?icaeoeii iie?i?aaiii? iaaeinoaoiino? oa aeiaaa? i?iaaaeaiiy caoiae?a ?ioaineaii? oa?ai?? c canoinoaaiiyi iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe??. A ?acoeueoao? noaiaeiaeo aeine?aeaeaiiue aeiaaaeaii, ui a?iniaoeeo?/i? ni?aaioe oae naii aoaeoeaii aaeni?aothoue ia nia? iaoaaie?oe, ye ? iao?e/i? ni?aaioe, ia iniia? yeeo aiie aeaioiaeai? (oaae.3). Oaaeeoey 3- Ni?aoe?eia aeoeai?noue ??cieo oei?a ni?aaio?a a noaiaeiaeo aeine?aeaeaiiyo. ? iiNi?aaio (n=20)A?e??oa?i ( ieiieue/e)E?aao?i?i (iiieue/e)Na/iaeia (ieiieue/e)Oe?E (oiia.iae.)Aeo?aeiee ??aaiue105,618,670,2140,06310,810,41240,004,8211.NEI49,042,580,0990,0128 ,490,27168,042,9282.AOAeN37,932,320,1220,0259,170,32143,67,0283.AON “Aei?i?i”39,41,990,1030,0258,790,21156,450,2324.AOAeN34,202,320,1520,017 9,410,31146,001,940P1-2<0,01<0,01<0,05<0,01P3-4<0,05<0,05>0,05<0,05 Iacia/ia ??cieoey a aaeni?aoth/eo aeanoeainoyo coiiaeaia o?enaoe??th ia iao?eoe? iaoeaii? oeionii? AeIE, ui ciaioo? aeoeaio iiaa?oith ni?aaioa. I?ioa, ciaioaiiy aeoeaii? iiaa?oi? ni?aaioo ia i?ecaiaeeoue a cia/i?e i??? aei cieaeaiiy eiai aeaoieneeoth/eo aeanoeainoae. I?e aeine?aeaeaii? aieeao iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? ia iieacieee a?eeiaiai iaoaaie?cio, a oaeiae ia iieacieee ooieoe?iiaeueiiai noaio ia/?iee oa ie?ie , ne?ae a?aecia/eoe, ui iaoiaee ni?aoe?eii? aeaoieneeaoe?? iathoue a?eueo ae?aaeaiee caaaeueiiaeaoieneeoth/ee oa a?eeiaiei?aaoth/ee aieea ia i?ioeane aiiainoaco o oai?eo c neiae?iiii aiaeioieneeico. Oae ia 7 aeiao i?ney ni?aoe?? ??aaiue a?e??oa?io cieaeoaaany c 107,362,23 ieiieuee aei 29,2503,026 ieiieuee, a oie /an ye i?ney ieaciaoa?aco cieaeoaaany aei 52,132 1,356 ieiieuee , a a eiio?ieuei?e a?oi? aei 79,543 2,342 ieiieuee ( ??cieoey i?ae a?oiaie aeinoia??ia, p<0,05). ??aaiue e?aao?i?io cieaeoaaany c 0,1920,05 iieieuee aei 0,0930,02 iiieuee ( i?ney ieaciaoa?aco - aei 0,0960,02 iiieuee , a eiio?ieuei?e a?oi? aei 0,1780,04 iiieuee (p<0,05)), a na/iaeie a?aeiia?aeii c 10,651,21 ieiieuee aei 6,561,32 ieiieuee a ia?o?e a?oi?, 7,920,34 ieiieuee a ae?oa?e a?oi? oa 9,431,03 ieiieuee a eiio?ieuei?e ( p<0,05). Ieaciini?aoe?y oi/a aeaui iinooia?oueny ca nai?th aoaeoeai?noth aaiini?aoe?? , ? a?eueo neeaaeiith oa eeii?oeith a oaoi?/iiio ieai? i?ioeaaeo?ith, i?ioa aiia a?eueo aacia/ia a ii??aiyii? c ieaciaoa?acii ui aei ?icaeoeo oneeaaeiaiue, iia’ycaieo c aenooc??th ieacie.Oae i?ney ieaciaoa?aco ??aaiue caaaeueiiai a?eea cieaeoaaany ia 8,440,21 ae, oiae? ye i?ney ieaciini?aoe?? eeoa ia 0, 420,51 ae, ??aaiue aeueaoi?io cieaeoaaany a?aeiia?aeii ia13,41,22 ae oa ia 9,60,62 ae ( ??cieoey a a?oiao aeinoia??ia, p<0,05). sse iieacaee ?acoeueoaoe ?ioiieia?/ieo aeine?aeaeaiue , o an?o iaoe?aio?a c caoai?thaaiiyie ia/?iee a?aei?/aeeny ci?ie ?ioiiiai noaoono, ui ae?aaeaeeny cieaeaiiyi iieaciee?a ee?oeiiiai ?ioi?oaoo, cie?aia a?aeiinii? e?eueeino? O-e?ioioeeo?a ia 18 - 20%, noaiiioeyoe?? OO* – ?OE ia 8-10%, OO?-?IE ia 4-6%. Ui noino?oueny iieaciee?a A-nenoaie ?ioi?oaoo, oi i?e ciaioaii? e?eueeino? AAN – ?OE ia 5-7 %, a?aei?/a?oueny i?aeaeuaiiy ??aiy IgM ia 12%, IgG ia 73%, Ig A ia 104%, Oe?E ia 131% . I?ney i?iaaaeaiiy aaii?ioiini?aoe?? ia 10 aeiao a?aeaoaa?oueny c?inoaiiy e?eueeino? O- ( ia 24,3%) ? A-e?ioioeeo?a ( ia 13,5%) a?aeiinii aeo?aeiiai ??aiy (p<0,05), cieaeaiiy OO?OO* ni?aa?aeiioaiiy ia 32,1%. A a?oi?, aea canoiniaoaaeanue o?aaeeoe?eia oa?ai?y, ia 10 aeiao ia a?aei?/aii aeinoia??ii? ??cieoe? iieaciee?a a ii??aiyii? c aeo?aeiei ??aiai . Aaii?ioiini?aoe?y ia? ae?aaeaiee ?ioiiei?aaoth/ee aoaeo, ui i?iyaey?oueny cia/iei cieaeaiiyi a?aeiinii aeo?aeiiai ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a c 224,178,58 aei 104,8 1,31 oiiai.iae. , Ig G ( c 23,610,65 ae aei 14,7630,57 ae) oa IgA ( c 4,1930,12 ae aei 2,960,16 ae) ( p<0,05), i?e oeueiio ia? i?noea a?aeiinia i?aeaeuaiiy ??aith Ig Mn ( c 1,230,07ae aei 1,570,07 ae). C ee?i?/ieo iieaciee?a aoaeoeaiino? iaoiae e?eoaaiiy neiae?iio aiaeioieneeico a a?oi? c canoinoaaiiyi ni?aoe?eii? aeaoieneeaoe?? a?aei?/aeanue iaeieae/a nia?oi?noue – 4%, oa iaeaeuee i?ioeaio aeaeoaeaiiy oa iie?auaiiy noaio-76%, a a?oi? c canoinoaaiiyi ieaciaoa?aco iiceoeaiee aoaeo niinoa??aa?oueny o 56% oai?eo. Aeey iioeiaeueiiai i?iaaaeaiiy o?ainooc?eii-aeaoieneeaoe?eii? oa?ai?? neiae?iio aiaeioieneeico ?ic?iaeaii aeai?eoi i?ecia/aiiy eiiieaenii? oa?ai?? c iaeyaeo ia noai oai?iai, ee?i?/i? oa eaai?aoi?i? iieacieee , noaio aeai?o iaoiaeo aeno?aei?ii?aeueii? aeaoieneeaoe?? c o?aooaaiiyi iiaeeeaeo oneeaaeiaiue oa caoiaeaie ii ?o i?io?eaeoeoe? (?en.2). A?aeiia?aeii aei noaie, oai?ei c oai?ei aac noiooiuei? iie?i?aaiii? iaaeinoaoiino? i?e aiaeioieneeic? eaaeiai nooiaiy iiaeeeaa i?iaaaeaiiy aaiini?aoe?? ia?aeaeueii c o?aaeeoe?eiith oa?ai??th. Oai?ei c i?iyaaie oiene/ii? aioeaoaeiiao?? i?iaiaeeoueny eiiieaen aianoac?ieia?/iiai caaacia/aiiy ( aeea. i?aeoe/i? ?aeiiaiaeaoe??). I?e aiai?caoe?? oa ii?ooaiiyo aaiinoaco aeioe?eueia i?iaaaeaiiy ieaciaoa?aco c ia?aeaeueiith aaiio?ainooc??th (ia?aeeaaiiyi a??o?ioeeoa?ii? iane), a i?ney noaa?e?caoe?? iieaciee?a iiaeeeaa i?iaaaeaiiy aaiini?aoe?? c ?iaeea?aeoaeueiei i?aeai?ii iaoiaeo aaia?ei?caoe??. Oai?ei c a?iii?ioa?iai??th iieacaii i?iaaaeaiiy ?iooc?? aeueaoi?io, ieaciini?aoe?y, ?iooc?y na?aeicaii?iaeaii? ieacie. Ei?enooth/enue cai?iiiiiaaiith noaiith, a?aoiaoth/e iieacaiiy oa i?ioeiieacaiiy aei i?iaaaeaiiy aeno?aei?ii?aeueii? aeaoieneeaoe??, aeey eiaeiiai iaoe?aioa iiaeeeai i?ae?a?aoe iioeiaeueio oaeoeeo i?iaaaeaiiy oa?ai?? c canoinoaaiiyi iioeiaeueiiai iaoiaeo aeno?aei?ii?aeueii? aeaoieneeaoe??. Nooi?iue aiaeioieneeico: EAAEEE o?aaeeoe?eia oa?ai?y +aaiini?aoe?y NA?AAeI?E , aac oyaeeeo oneeaaeiaiue o?aaeeoe?eia oa?ai?y OssAEEEE ONEEAAeIAIIss: Na?oeaai-noaeeiia iaaeinoaoi?noue Aino?a aeeoaeueia iaaeeeaiaioicia, ?iooc?eia, AAIINI?AOe?ss iaaeinoaoi?noue ieneaaiioa?ai?y + Aioeaoaeiiao?y eiiieaen aianoac?ieia?/iiai caaacia/aiiy + Aiai?y Ieaciaoa?ac + aaiio?ainooc?y + Aaii?aa?/iee aaiinoaoe/ia oa?ai?y neiae?ii + Ieaciaoa?ac + aaiio?ainooc?y + + aea?? iaoiaee aaia?ei?caoe?? A?iii?ioa?iai?y ?iooc?y aeueaoi?io + Ieacii?ioiini?aoe?y + ?iooc?y ieacie OA?I?IAEUeIEE iaaeeeaiaioicia , aia?aoia i?aeo?eiea a?oaeueieo ooieoe?e ii aeeoo?aeo iieacaiiyo ?en. 2 - Noaia aeai?o iaoiaeo AEAe c o?aooaaiiyi noaio iaoe?aioa. AENIIAEE 1. Neiae?ii aiaeioieneeico i?e caoai?thaaiiyo ia/?iee i?ecaiaeeoue aei o?aaeaiiy aeeoo?aiaaaeeeaeo i?aai?a oa nenoai c aeieeiaiiyi aooi?ioiieo ii?ooaiue ? ?icaeoeii iie?i?aaiii? iaaeinoaoiino?, ui iio?aao? canoinoaaiiy iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? iai?aaeaii? ae??. 2. ?icaeoie aiaeioienai?? noi?iaiaeaeo?oueny i?eai?/aiiyi ee?oeiiiai ?ioi?oaoo, ui i?iyaey?oueny cieaeaiiyi e?eueeino? O-e?ioioeeo?a ia 18 - 20%, noaiiioeyoe?? OO* – ?OE ia 8-10%, OO?-?IE ia 4-6%, noiniaii iieaciee?a A-nenoaie ?ioi?oaoo, oi i?e ciaioaii? e?eueeino? AAN – ?OE ia 5-7 %, a?aei?/a?oueny i?aeaeuaiiy ??aith IgM ia 12,5%, IgG ia 73,2%, Ig A ia 104,3%, Oe?E ia 131,5%. 3. I?iaaaeaiiy aaii?ioiini?aoe?? i?ecaiaeeoue aei c?inoaiiy e?eueeino? O-( ia 24,3%) ? A-e?ioioeeo?a ( ia 13,5%) a?aeiinii aeo?aeiiai ??aiy, cieaeaiiy OO?OO* ni?aa?aeiioaiiy ia 32,1%. Aaii?ioiini?aoe?y ia? ae?aaeaiee ?ioiiei?aaoth/ee aoaeo, ui i?iyaey?oueny cia/iei cieaeaiiyi oee?eoethth/eo ?ioiieo eiiieaen?a ia 60,2%, Ig G ia 47,2% oa IgA ia 70,3%, i?e oeueiio ia? i?noea a?aeiinia i?aeaeuaiiy ??aiy Ig M ia 27,1%. 4. Canoinoaaiiy iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? nooo?ai cieaeo? ??aaiue a?e??oa?io - ia 63,1% ( i?e aaiini?aoe??) oa – 22,2% ( i?e ieaciaoa?ac?), AEO ia 57,5 % ( 39,3%), ANO – ia 30,9% (29,5%) a ii??aiyii? c aeeiai?eith oeeo iieaciee?a i?e canoinoaaii? o?aaeeoe?eii? oa?ai??, ui aeaco? ia ?o aoaeoeai?noue i?e e?eoaaii? i?ia?anoth/i? ia/?ieiai? iaaeinoaoiino?. 5. Aeeth/aiiy iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe?? iai?aaeaii? ae?? i?ecaiaeeoue aei iie?auaiiy ee?i?/iiai noaio iaoe?aio?a, cieaeaiiy nia?oiino? ia 14,1 %, ca?eueoaiiy i?ioeaioo aeaeoaeaiiy ia 16,1 % oa iie?auaiiy ee?i?/iiai noaio iaoe?aio?a ia 22,2 %. 6. Eiia?iiaaia aeei?enoaiiy aaiini?aoe?? ia a?iniaoeeo?/ieo ni?aaioao, ieaciini?aoe?? oa e?eoaaeueiiai ieaciaoa?aco a oiiaao i?iaaaeaiiy aianoac?ieia?/iiai caaacia/aiiy, yea ia aieeaa? ia ooieoe?iiaeueiee noai ia/?iee, ii?yae c o?aaeeoe?eiith oa?ai??th cia/ii i?aeaeuo? aoaeoeai?noue e?eoaaiiy, i?enei?th? aeaeoaeaiiy iaoe??ioa, a a ie?aieo aeiaaeeao ?yoo? aeeooy oai?iai. I?AEOE*I? ?AEIIAIAeAOe?? 1. C iaoith i?aeaeuaiiiy aoaeoeaiino? iii?oi?eiao oa e?eoaaeueiiai aieeao ?aeiiaiaeiaaii canoinoaaiiy nenoaie ioe?iee oyaeeino? o?aaeaiiy i?aai?a oa nenoai. 2. A eiiieaen? oa?aiaaoe/ieo caoiae?a iai?aaeaieo ia e?ea?aeaoe?th aiaeioienai?? iiaeii? canoiniaoaaoenue iaoiaee aeno?aei?ii?aeueii? aeaoieneeaoe??. Iieacaiiy aeey i?iaaaeaiiy iaoiae?a AEAe ? : - Neiae?ii aiaeioieneeico na?aaeiueiai aai oyaeeiai nooiaiy, iacaeaaeii a?ae i?e/eie, ui eiai aeeeeeaea. - I?e eaaeiio nooiai? aiaeioieneeico iathoue i?noea a?aeiini? iieacaiiy aei ?ioiini?aoe??, ine?eueee iiaeeeaa eiina?aaoeaia oa?ai?y oeueiai oneeaaeiaiiy aac aeei?enoaiiy iaoiae?a AEAe. Oiio iieacaiiyie aei i?iaaaeaiiy aenoa?ei?ii?aeueii? aeaoieneeaoe?? a oeueiio aeiaaeeo aoaeooue: a) ia/?ieiaa iaaeinoaoi?noue, iaoai?/ia aeiaoyieoey, ui noi?iaiaeaeo?oueny a?ia?a?e??oa?iai??th a?eueo 50 ieiieuee oa yaeuaie oiene/ii? aioeaoaeiiao??, a) aeiaaio?eaath/? ?aaeoe?? a?ia?/ooeeaino? : neiae?ii Eae?ea, No?aaia-Aeaeiina, e?iieaieoey c ?icaeoeii ia/?ieiai? iaaeinoaoiino?. I?e oa?i?iaeueiiio (e?eoe/iiio) aiaeioieneeic? iaoiaee AEAe canoiniaothoueny i?e a?aenooiino? aaniethoieo i?ioeiieacaiue ca oiia iaaeeeaiaioicii? oa aia?aoii? i?aeo?eiee a?oaeueieo ooieoe?e. 3. Aaniethoieie i?ioeiieacaiiyie aei i?iaaaeaiiy iaoiae AEAe ?: a) aino?a o??o?a?/ia iaoieia?y ui iio?aao? iaaaeiiai iia?aoeaiiai ao?o/aiiy. a) na?oeaai-noaeeiia iaaeinoaoi?noue 3 nooiaiy, aeeeeeaia ea?ae?aeueieie aai aeno?aea?ae?aeueieie i?e/eiaie, a) o?iiai-aaii?aa?/iee neiae?ii a noaae?? eiaaoeiiao?? niiaeeaaiiy c iiiaeeiieie iie?oiiieie e?iaioa/aie. ?io? oneeaaeiaiiy aiaeioieneeico - aiai?y, o?iiaioeeoiiai?y, a?iiaieai?y, iae?i-aioeaoaeiiao?y - yaeythoue niaith a?aeiini? i?ioeiieacaiiy aei iaaaeii? aaiini?aoe??, oa iiaeooue aooe onoiai? aai nei?aaiaai? aeiiii?aeiith oa?ai??th, ui aoiaeeoue a eiiieaen caoiae?a ii aianoac?ieia?/iiio caaacia/aiith oa i?io?eaeoeoe? iiaeeeaeo oneeaaeiaiue. 4. Aeey aeai?o iaoiaeo aeno?aei?ii?aeueii? aeaoieneeaoe?? c o?aooaaiiyi nooiaiy oyaeeino? aiaeioieneeico, ii?ooaiue i?aai?a oa nenoai iaiao?aeii canoiniaoaaoe aeai?eoi?/io noaio, ui a?aoiao? aieiai? iieacaiiy, i?ioeiieacaiiy oa oeyoe iaoiaeieia?/iiai i?aeoiaeo. 5. Aeey aacia/iiai i?iaaaeaiiy iaoiae?a AEAe o oai?eo c aiaeioienai??th ?aeiiaiaeiaaii a eiiieaen? i?aiaae?eaoe?? canoinoaaiiy ia ia?aaeiaei? i?ioeaaeo?e ia i?/ Iiai?acieo a aeic? 40 ia oa ca 2 aiaeeie aei ni?aoe?? - 20 ia ia?i?aeueii. I?e iaiao?aeiino? iiaii? naaeaoe??, e?ea?aeaoe?? ineoiiioi?iiai caoaeaeaiiy ?aeiiaiaeiaaii i?iaaaeaiiy aioo??oiueiaaiiiai ia?eico i?iiioieii a aeic? 2-3 ieaeaaiae (ca?aeii caaaeueiii?eeiyoeo aianoac?ieia?/ieo iaoiae). 6. O oai?eo c ii?iaeueieie iieacieeaie eiaaoeia?aiie caaaeueia aaia?ei?caoe?y iiaeiia cae?enithaaoenue c ?ic?aooieo 200-300 iaeeieoeue aaia?eio ia 1 ea aaae. O oai?eo c i?iyaaie a?iieiaaoeyoe?? iiaeiia canoioiniaoaaoenue iaoiaea ?aa?iia?ii? aaia?ei?caoe??, i?e ye?e i?iaiaeeoueny i?iieaea eieiiee ia?aae i?aeeeth/aiiyi iaoe??ioa 1000 ie o?c?ieia?/iiai ?ic/eio c aeiaeaaaiiyi 10 000 iae. aaia?eio. Aioo??oiueiaaiii aaiaeeoueny aaia?ei c ?ic?aooieo 60 - 70 iae.ea. Aeey caiia?aaiiy o?iiaico eieiiee ia??iaee/ii i?iaiaeeoueny i?iieaaiiy ?? o?c?ieia?/iei ?ic/eiii c aaia?eiii (5000 iae /1000 ie) /a?ac nenoaio ci?ooaa/?a, c iaeo?ae?caoe??th ia aeoiae? c eieiiee ?ic/eiii i?ioai?i - noeueoaoo a ni?aa?aeiioaii? 1 : 0,5. O oai?eo c ee?i?ei-eaai?aoi?ieie i?iyaaie aaii?aa?/iiai neiae?iio iioeiaeueiei aeey aaia?ei?caoe?? ? canoinoaaiiy iecueeiiieaeoey?iiai aaia?eio - o?aen?ia?eio. I?e oeueiio o?aen?ia?ei i?ecia/a?oueny ca aeiao aei ni?aoe?? a aeic? 0.6 ia aea?/e ia aeaiue, a ca 3 aiaeeie aei ii/aoeo i?ioeaaeo?e aaiaeeoueny ua 0,6 ia i?aeoe??ii. I?ney /iai i?iaiaeeoueny i?iieaea eieiiee o?c?ic/eiii c aaia?eiii. Aeiaeaoeiaa aaia?ei?caoe?y ia canoiniao?oueny. 7. I?e i?iaaaeaii? o?ainooc?eii? oa?ai?? ne?ae aeei?enoiaoaaoe eaeeioeeoa?i? o?eueo?e, ye? caiia?aathoue HLA- ?ioi?caoe?th oa ?ioiinoi?an?th, iaaaiie?oe/i? o?a?eeuei? ?aaeoe??, ciaioothoue /anoioo iinoo?ainooc?eieo ?aaeoe?e, aeicaieythoue iiia?aaeaeoaaoe aeieeiaiiy ?ani??aoi?iiai aeeno?an-neiae?iio oa o?iiaioeeoiiai?th, ui ? iniaeeai aaaeeeaei o oai?eo c oyaeeei ia?aa?aii aiaeioieneeico. Na?aae eaeeioeeoa?ieo o?eueo??a iaea?eueo aeioe?eueiei ? canoinoaaiiy o?eueo??a Rc 50,RC100, RCXL, SQ 40S ae?iaieoeoaa o??ie “PALL” (NOA). NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. Canoinoaaiiy iaoiaeo aaiini?aoe?? c aeei?enoaiiyi ni?aaioo AOAeN, ui i?noeoue AeIE, a ?ioaineai?e oa?ai?? neiae?iio aiaeioieneeico o o??o?a?/ieo oai?eo. // Ee?i?/ia o??o?a?y.-1997.-?11-12.-N.98. 2. Eeeie/aneay oa?aeoa?enoeea iaaeeoeeineeo oeeueo?ia. // Ee?i?/ia o??o?a?y.-1997.-? 3-4.-N.97-99. ( ni?aaao.Noa?eeia A.A., Eiaaeue A.A.). 3. Canoinoaaiiy Aeei?eaaio o aianoac?ieia?/iiio caaacia/aii? iaeeo a?iaeieia?/ieo iia?aoe?e o ae?iie a ia??iae? ee?iaeoa??th. // Iaae?ao??y, aeooa?noai, a?iaeieia?y.-1997.-?6.-N.123-125.( ni?aaao. Oaoa?/oe O.O., ?aaaaea N.?., Caoa?aiei I.O.). 4. Iniaeeaino? ia?aa?ao neiae?iio aiaeioieneeico i?e ai?eii-caiaethaaeueieo caoai?thaaiiyo i?eaeaoe?a iaoee o ae?iie c ?aiiueith iaiiiaocith. //Iaae?ao??y, aeooa?noai, a?iaeieia?y.-1997-?2.-N.90-91.(ni?aaao.Nieuenueeee ss.I.,Na?e?nyi A.A.,Oaoa?/oe O.O.,Caoa?aiei I.O., Einae I.A.). 5. Ei?aeoe?y nenoaie aaiinoaco i?ae /an i?iaaaeaiiy aaiini?aoe?? o oai?eo c neiae?iiii aiaeioieneeico.// E?ee Oe?a?ie .-1999.- ?4.-N.30-31.( ni?aaao. Eeoaeiia A.N.). 6. Canoinoaaiiy a?iniaoeeo?/iiai aaiini?aaioo AOAeN a e?eoaaii? ?ioiicaeaaeieo caoai?thaaiue o iaoe??io?a c /enea e?ea?aeaoi??a iane?aee?a aaa??? ia *AAN.// Oac.iaoeiai-i?aeoe/.eiioa?. “A?aeaeaeai? iane?aeee ii?ii?iaiiy a ?ioii?e oa aaiiiiaoe/i?e nenoaiao”, Ee?a-1997.-N.138. 7. Nenoaia ioe?iee iie?i?aaiii? iaaeinoaoiino? o iaoe??io?a c neiae?iiii aiaeioieneeico.//Iao.iaoe.-i?aeo.eiioa?.”Aeooaeuei? ieoaiiy iaaeeoeeie”, i?enay/aii? 30-??//th Oeaio?aeueiiai aini?oaeth IAN Oe?a?ie,Ee?a.-1997.-N.102. 8. Ii??aiyiiy aoaeoeaiino? oa aacia/iino? ieacii?ioiini?aoe?? oa e?eoaaeueiiai ieaciaoa?aco o oai?eo c aiaeioienai??th. // Iao.iaoe.-i?aeo.eiioa?.”Aeooaeuei? ieoaiiy iaaeeoeeie”, i?enay/aii? 30-??//th Oeaio?aeueiiai aini?oaeth IAN Oe?a?ie, Ee?a.-1997.-N.103. 9. Aeoeai?noue aioo??oiueiee?oeiieo oa?iaio?a iaeo?io?e?a o oai?eo c ia/?ieiaith iaaeinoaoi?noth i?e i?iaaaeaii? aaiini?aoe?? oa ieaciaoa?aco. // Iao.iaoe.-i?aeo.eiioa?.”Aeooaeuei? ieoaiiy iaaeeoeeie”, i?enay/aii? 30-??//th Oeaio?aeueiiai aini?oaeth IAN Oe?a?ie,Ee?a.-1997.-N.101. (ni?aaao. Ienaieoia I.A.). AIIOAOe?ss A.A.Noaaethe. O?ainooc?eii-aeaoieneeaoe?eia oa?ai?y neiae?iio aiaeioieneeico i?e caoai?thaaiiyo ia/?iee c canoinoaaiiyi a?iniaoeeo?/ieo aaiini?aaio?a. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.31.- aaiaoieia?y oa o?ainooc?ieia?y. - Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a?ie, Ee?a,1999. ?iaioa i?enay/aia ieoaiiyi eiiieaenii? ioe?iee noaio iaoe??io?a c caoai?thaaiiyie aaiaoi-a?e?a?ii? nenoaie, ui oneeaaeieeenue ?icaeoeii neiae?iio aiaeioieneeico, oa i?iaaaeaiith ?ioaineaii? o?ainooc?eii-aeaoieneeaoe?eii? oa?ai?? c canoinoaaiiyi iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe??. Aeine?aeaeaii iniaeeaino? i?iyao iie?i?aaiii? iaaeinoaoiino? i?e neiae?ii? aiaeioieneeico o oai?eo c iaoieia??th ia/?iee, eaai?aoi?io oa ee?i?/io aoaeoeai?noue ??cieo iaoiae?a aeno?aei?ii?aeueii? aeaoieneeaoe??. I?iaaaeaii ii??aiyeueio ioe?ieo aoaeoeaiino? aaiini?aoe?? ia iao?e/ieo oa a?iniaoeeo?/ieo, AeIE- i?noy/eo aaiini?aaioao. ?ic?iaeaia nenoaia ioe?iee nooiaiy oyaeeino? aiaeioieneeica a caeaaeiino? a?ae i?iya?a iie?i?aaiii? iaaeinoaoiino?, aecia/ai? iieacaiiy oa i?ioeiieacaiiy aei i?iaaaeaiiy aoa?aioieo iaoiae?a aaiioa?ai??. Eeth/ia? neiaa: aiaeioieneeic, aeno?aei?ii?aeueia aeaoieneeaoe?y, a?iniaoeeo?/i? aaiini?aaioe, aaiini?aoe?y, ieaciaoa?ac. AIIIOAOeEss A.A.Noaaethe. O?ainooceiiii-aeaoieneeaoeeiiiay oa?aiey neiae?iia yiaeioieneeica i?e caaieaaaieyo ia/aie n i?eiaiaieai aeiniaoeeoe/aneeo ni?aaioia.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.31. - aaiaoieiaey e o?ainooceieiaey. - Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo aaiaoieiaee e ia?aeeaaiey e?iae IC Oe?aeiu,Eeaa ,1999. ?aaioa iinayuaia aii?inai eiiieaeniie ioeaiee ninoiyiey iaoeeaioia n caaieaaaieyie aaiaoi-aeeea?iie nenoaiu n neiae?iiii yiaeioieneeica e i?iaaaeaieth eioaineaiie o?ainooceiiii-aeaoieneeaoeeiiiie oa?aiee n i?eiaiaieai iaoiaeia yeno?aei?ii?aeueiie aeaoieneeaoeee i?e aeaiiii ineiaeiaiee. A i?ioeanna ?aaiou iaae aeenna?oaoeeae i?iaaaeaii eeeie/aneia ianeaaeiaaiea e ea/aiea 149 aieueiuo n iaoieiaeae aaiaoi-aeeea?iie nenoaiu. Aieueiua auee ?ani?aaeaeaiu ii a?oiiai . Aieueiui ia?aie a?oiiu a eiiieaena oa?aiaaoe/aneeo ia? auea i?iaaaeaia aaiini?aoeey ia aaiini?aaioa AOAeN ( aaiini?aaio oaea?iaeiue AeIE-niaea?aeauee, n oeene?iaaiie iaoeaiie oeioniie AeIE), aieueiui aoi?ie iiuoiie a?oiiu i?iaaaeai oa?aiaaoe/aneee ieaciaoa?ac, aieueiua eiio?ieueiie a?oiiu iieo/aee oieueei o?aaeeoeeiiioth oa?aieth. N oeaeueth iauaeoeaecaoeee eeeie/aneeo aeaiiuo, ii?aaeaeaiey noaiaie au?aaeaiiinoe iieei?aaiiie iaaeinoaoi/iinoe e oyaeanoe neiae?iia yiaeioieneeica, ?ac?aaioaia nenoaia ioeaiee oyaeanoe ninoiyiey. Ioeaiea noaiaie oyaeanoe ninoiyiey i?iaiaeeeanue iooai ecia?aiey o iaoeeaioa iieacaoaeae aaiiaeeiaieee, ioeaiee ninoiyiey aeuoaoaeueiie e ia?aiie nenoai, ioeaiee eeeie/aneeo e aeioeie/aneeo aiaeecia e?iae, ii/aniaiai aeeo?aca, iieacaoaeae naa?ouaathuae nenoaiu e?iae, i?e eioi?ii eaaeaeue iieacaoaeue ioeaieaaeny a aaeeao, niioaaonoaaiii noaiaie ioeeiiaiey io ii?iu. Iinea yoiai i?iaiaeeeny ?ann/ao n?aaeiaa?eoiaoe/aneeo iieacaoaeae ioeeiiaiee ii eaaeaeie nenoaia. Noaiaiue oyaeanoe ii?aaeaeyeanue niioaaonoaaiii noiiu n?aaeiaa?eoiaoe/aneeo aaeeia ii nenoaiai e ii?aaeaeyeanue eae eaaeay aei 10 aaeeia, n?aaeiyy – aei 20 aaeeia, oyaeaeay – aei 30 aaeeia e e?eoe/aneay – aei 40 aaeeia. Eae iieacae aiaeec iieo/aiuo aeaiiuo, neiae?ii yiaeioieneeica i?e caaieaaaieyo aaiaoi-aeeea?iie nenoaiu i?eaiaeeo e ii?aaeaieth anao i?aaiia e nenoai n aicieeiiaaieai aooieioiiuo ia?ooaiee e ?acaeoeai iieei?aaiiie iaaeinoaoi/iinoe, /oi o?aaoao i?iaaaeaiey eioaineaiie oa?aiee n i?eiaiaieai iaoiaeia yeno?aei?ii?aeueiie aeaoieneeaoeee. ?acaeoea yiaeioienaiee nii?iaiaeaeaaony oaiaoaieai eeaoi/iiai eiioieoaoa, /oi i?iyaeyaony nieaeaieai O-eeioioeeoia ia 18 - 20%, noaiiioeyoeee OO* – ?IE ia 8-10%, OO?-?IE ia 4-6%. *oi eanaaony iieacaoaeae A-nenoaie eiioieoaoa, oi i?e oiaiueoaiee eiee/anoaa AAN – ?IE ia 5-7 %, ioia/aaony iiauoaiea o?iaiy IgM ia 12,5%, IgG ia 73,2%, Ig A ia 104,3%, OeEE ia 131,5% . I?iaaaeaiea aaiini?aoeee ia ni?aaioa AOAeN i?eaiaeeo e oaaee/aieth eiee/anoaa O- e A- eeioioeeoia( ia 24,3% e 13,5% niioaaonoaaiii),nieaeaieth o?iaiy OeEE ia 60,2%, Ig G ia 47,2% , IgA ia 70,3%, i?e yoii eiaao ianoi ioiineoaeueiia iiauoaiea Ig M ia 27,1%. I?eiaiaiea iaoiaeia yeno?aei?ii?aeueiie aeaoieneeaoeee cia/eoaeueii nieaeaao o?iaaiue aeee?oaeia - ia 63,1% ( i?e aaiini?aoeee) e ia 22,2% ( i?e ieaciaoa?aca), AEO ia 57,5 % ( 39,3%), ANO – ia 30,9% (29,5%) ii n?aaiaieth n aeeiaieeie yoeo iieacaoaeae i?e i?eiaiaiee o?aaeeoeeiiiie oa?aiee. Aeeth/aiea iaoiaeia yeno?aei?ii?aeueiie aeaoieneeaoeee iai?aaeaiiiai aeaenoaey i?eaiaeeo e oeo/oaieth eeeie/aneiai ninoiyiey aieueiuo. I?e i?eiaiaiee iaoiaeia YEAe ioia/aii nieaeaiea nia?oiinoe ia 14,1 %, oaaee/aiea i?ioeaioa aucaei?iaeaiey iaoeeaioia ia 16,1 % , oeo/oaiea eeeie/aneiai ninoiyiey ia 22,2 %. ?ac?aaioaiu i?aeoe/aneea ?aeiiaiaeaoeee ii i?iaaaeaieth iaoiaeia yeno?aei?ii?aeueiie aeaoieneeaoeee o aieueiuo n neiae?iiii yiaeioieneeica. ?aeiiaiaeiaaia noaia auai?a iaoiaea YEAe e oa?aiaaoe/aneie oaeoeee a caaeneiinoe io noaiaie oyaeanoe e i?iyaeaiee iieei?aaiiie iaaeinoaoi/iinoe. ?aeiiaiaeiaai niinia aianoaceieiae/aneiai iaania/aiey yeno?aei?ii?aeueiie aeaoieneeaoeee o aieueiuo n eioieneeaoeeiiiui aeaee?eai n i?eiaiaieai i?aia?aoa “Aeei?eaai”, ?acee/iua niiniau aaia?eiecaoeee, a caaeneiinoe io eeeieei-eaai?aoi?iuo iieacaoaeae nenoaiu aaiinoaca. Aeieacaii, /oi eiiaeie?iaaiia i?eiaiaiea aaiini?aoeee ia aeiniaoeeoe/aneeo aaiini?aaioao, ieaciini?aoeee e ea/aaiiai ieaciaoa?aca a oneiaeyo aianoaceieiae/aneiai iaania/aiey e i?aaeeueiie aaia?eiecaoeee cia/eoaeueii iiauoaao yooaeoeaiinoue ea/aiey, onei?yao aucaei?iaeaiea, a a ioaeaeueiuo neo/ayo nianaao aeeciue iaoeeaioa. Eeth/aaua neiaa: yiaeioieneeic, yeno?aei?ii?aeueiay aeaoieneeaoeey, aeiniaoeeoe/aneea aaiini?aaiou, aaiini?aoeey, ieaciaoa?ac. SUMMARY V.V.Steblyuk. Transfusional-detoxicational therapy of syndrom of endotoxicosis in hepatic pathology with using of biospecifical hemoadsorbents.- Manuscript. Thesis for a master;s degree in medicine in speciality of 14.01.31.- Hematology and blood transfussion. - Kiev Research Institute of Hematology and Blood Transfusion,Kiev, 1999. The manuscript is devoted to clinical investigation and complex appraisal of states patients with hepatic deseases with syndrom of endotoxicosis and conductions of intensive transfusional-detoxicational therapy with using methods of extracorporal detoxications. Particularity of polyorganic insufficiensy were studied in patients with hepatic deseases that were complicated by syndrom of endotoxicosis. Effectivity of methods of extracorporal detoxications ( carbo-hemoperfusion on biospecifical DNA- bearing adsorbents and therapeutic plasmapheresis ) was investigated in laboratry and clinical researches. System of complex appraisal of polyorganic pathology and program of transfusional-detoxicational therapy of syndrom of endotoxicosis with using methods of extracorporal detoxication and complex of complication’s prevention were reccomended to medical practice. Key words: endotoxicosis, extracorporal detoxication, biospecifical adsorbents, carbo-hemoperfusion, therapeutic plasmapheresis. I?aeienaii aei ae?oeo 18.08.99. Oi?iao 60o84/16 Iai?? ionaoiee. Ionaoiee ae?oe. Oi.-ae?oe. A?e. 1,25 Oe?aae 100 i?ei. Cai. 251. Ae?oea?iy IAN Oe?a?ie

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