15

I?I?NOA?NOAI INA?OE OE?A?IE

EE?ANUeEEE AeA?AEAAIEE OI?AIAAEUeII-AEIIII?*IEE OI?AA?NEOAO

EACA*AIEI Na?oeaia Aieiaeeie??aia

OAeE 664.91:620.2

OIAA?ICIAA*A OA?AEOA?ENOEEA EIIA?IIAAIEO I’ssNIEO EIINA?A?A, I?ECIA*AIEO
AeEss ?AOe?IIAEUeIIAI OA?*OAAIIss

Niaoe?aeuei?noue 05.18.15 — oiaa?iciaanoai oa?/iaeo i?iaeoeo?a

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa oaoi?/ieo iaoe

EE?A – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Ee?anueeiio aea?aeaaiiio oi?aiaaeueii-aeiiii?/iiio
oi?aa?neoao? I?iina?oe Oe?a?ie.

Iaoeiaee ea??aiee: eaiaeeaeao oaoi?/ieo iaoe, noa?oee iaoeiaee ni?a-

?ia?oiee I?eooeuenueea
Iaoae?y Aieiaeeie??aia —

Ee?anueeee aea?aeaaiee
oi?aiaaeueii-aeiiii?/iee

oi?aa?neoao, aeioeaio
eaoaae?e oiaa?iciaanoaa oa

aenia?oece i?iaeiaieue/eo
oiaa??a

Io?oe?ei? iiiiaioe: aeieoi? oaoi?/ieo iaoe, i?ioani?

Ne?ioiai ?aai Aaneeueiae/ —
Euea?anueea

eiia?oe?eia aeaaeai?y,
caa?aeoaa/ eaoaae?e oiaa?i-

ciaanoaa i?iaeiaieue/eo
oiaa??a

eaiaeeaeao oaoi?/ieo iaoe, noa?oee
iaoeiaee ni?a-

?ia?oiee Eaaeoeueea I?ia Iao??aia —
Oe?a?inueeee

iaoeiai-aeine?aeiee ?inoeooo oa?/oaaiiy,
noa?oee

iaoeiaee ni?a?ia?oiee eaai?aoi??? o?i?? oa

aenia?oece oa?/iaeo i?iaeoeo?a

I?ia?aeia onoaiiaa: Oe?a?inueeee aea?aeaaiee oi?aa?neoao oa?/iaeo

oaoiieia?e, eaoaae?a i’yna oa
i’ynieo i?iaeoeo?a,

I?iina?oe Oe?a?ie, i.Ee?a.

Caoeno a?aeaoaeaoueny » 3 » ethoiai 2000 ?. i 11 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.055.02 i?e Ee?anueeiio aea?aeaaiiio
oi?aiaaeueii-aeiiii?/iiio oi?aa?neoao? ca aae?anith: 02156, i. Ee?a,
aoe. E?ioi, 19.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai
aea?aeaaiiai oi?aiaaeueii-aeiiii?/iiai oi?aa?neoaoo ca aae?anith: 02156,
i. Ee?a, aoe. E?ioi, 19.

Aaoi?aoa?ao ?ic?neaiee » 29 » a?oaeiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
Oeuaiei ?.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Neeaaei? oiiae i?iaeeaaiiy ianaeaiiy Oe?a?ie, ui
iia’ycai? c ii?ooaiiyi aeieia?? oa nioe?aeueii-aeiiii?/ieie ci?iaie,
iio?aaothoue iie?auaiiy eiai oa?/iaiai noaoono. O ca’yceo c oeei
?ic?iaea aenieiye?nieo i?iaeoeo?a oa?/oaaiiy c aa?aioiaaiei ai?noii
oe?ieiai niaeo?a iiaeeaieo ?a/iaei iaaoaa? iniaeeaiai cia/aiiy. Iaeiae
i?e no/aniiio ??ai? ne?iaeiieo ?ano?n?a iiaeeeaino? io?eiaiiy oaeeo
i?iaeoeo?a iaiaaeai?. A oeueiio ieai? aaaeeeao ?ieue a?ae?a?a? caeo/aiiy
iiaeo aeaea?ae a?ieia?/ii aeoeaieo eiiiiiaio?a aei oa?/iaiai ?aoe?iio,
cie?aia ae??aeaeaeiaeo aeiaaaie, io?eiaieo oeyoii i?e?ia?ieia?/iiai
neioaco, aeei?enoaiiy yeeo ia? ?yae ia?aaaa: aeiiii?/i?noue, i?inoioa ?
aeinooii?noue oaoi?/iiai iniauaiiy, iiaeeea?noue ?aaoethaaiiy ianya?a
ae?iaieoeoaa, iacaeaaei?noue a?ae aeieia?/ieo oiia, iiaeiaaeaiee no?ie
caa??aaiiy. Aeooae?caoe?y ?icaeoeo iacaaii? ?iaeono??? oaeiae iia’ycaia
c ae??oaiiyi caaea/? ia?a?iaee oe?aiiaea?nueeeo ae??aeaeae?a ye
a?aeoiae?a nie?oiaiai ae?iaieoeoaa ? iaiao?aeiino? noai?aiiy a?o/eciyii?
aeueoa?iaoeae aeiaaaeai ?iicaiiiai iioiaeaeaiiy.

Ca no/anieo oiia ?ic?iaea ?aoeaioo? i?iaeoeo?a, caeaa?eueoiai,
aaco?oueny ia ?aae?caoe?? iaei??? oi?iae?ciaaii? aeiiae, iai?eeeaae,
noai?aiiy i?iaeoeo?a caaeainiaaiiai ai?iieeneioiiai neeaaeo (A?aaei?eia
I.I., Ieoaeeia I.I., *a?i?eia I.I., Eiaaeaa I.?.). O oie /an ye aenieee
??aaiue ?icaeoeo eiii’thoa?ii? oaoiieia?? aea? iiaeeea?noue
ai?iaaaeaeoaaoe iia? eiiieaeni? i?aeoiaee aeey noai?aiiy aenieiye?nieo
i?iaeoeo?a oa?/oaaiiy caaeaiiai o?i?/iiai neeaaeo. Oiio iniaeeaiai
cia/aiiy iaaoaa? iiaeaethaaiiy ?ioaa?aeueii? yeino? oa?/iaeo nenoai c
aeei?enoaiiyi eiii’thoa?ii? i?ia?aie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue ia eaoaae?? oiaa?iciaanoaa oa aenia?oece i?iaeiaieue/eo
oiaa??a EAeOAO o ni?aae?oaeiino? c Oe?IAe?nie?oa?ii?iae ca?aeii c
iaoeiaeie ieaiaie ca ne?aeoth/eie oaiaie:

I?aeaaeocaaa iaoeiai-oaoi?/ia i?ia?aia «Oa?/iaee a?eie» ca i?iaeoii
11.03.08 I?iiaoee Oe?a?ie, caaaeaiiy 0196 V008842 OAeE
641.12:[642.31-664002.3] «?ic?iaeoe oaoiieia?th oa?/iaeo a?eeiaeo ?
niaeiaeo i?iaeoeo?a c ae??aeaeae?a-naoa?ii?oeao?a ia iniia? eiiieaenii?
aaca?aeo?aeii? ia?a?iaee ? noai?eoe i?iaeoeoe oa?/oaaiiy c ?o
aeei?enoaiiyi» ia 1993 ??e;

UA 01000031OP OAeE 664.663.05 «Oa?/ia? i?iaeoeoe iiaiai iieie?iiy»
ca?aeii c Aea?aeaaiith i?ia?aiith «Aenieiaoaeoeai? i?ioeane ae?iaieoeoaa
i?iaeiaieuenoaa» ia 1992-1994 ??.

Iaoa ? caaea/? aeine?aeaeaiiy. Aeoiaey/e c aeua cacia/aiiai iaie
noi?ioeueiaaia ne?aeoth/a iaoa aeine?aeaeaiue: ?ic?iaeoe ca aeiiiiiaith
eiii’thoa?ii? i?ia?aie ?aoe?iiaeuei? ?aoeaioo?e eiia?iiaaieo i’ynieo
oa?oo ? iaooaoo ia iniia? o?aaeeoe?eii? ne?iaeie oa c aeei?enoaiiyi
oa?/iaeo aeiaaaie i?e?ia?ieia?/iiai neioaco, ae?iaeoe ?o aeine?aei?
ia?o?? a oiiaao i?iieneiaino? ? aeaoe oiaa?iciaa/o ioe?ieo yeino?
eiia?iiaaieo i’ynieo eiina?a?a.

Aeey aeinyaiaiiy iinoaaeaii? iaoe iaiao?aeii aoei ae??oeoe ?yae
caaaeaiue:

? i?iaiae?coaaoe a?o/eciyi? oa caei?aeiii? e?oa?aoo?i? aeaea?aea ca
ia?aiei iai?yieii aeine?aeaeaiue;

? aecia/eoe iaoeiao eiioeaioe?th oa e?eoa??? iioei?caoe?? oa?/iaeo
i?iaeoeo?a a?aeiia?aeii aei no/anieo oyaeaiue iaoee i?i oa?/oaaiiy;

? aeine?aeeoe oa?/iao oa a?ieia?/io oe?ii?noue, ooieoe?iiaeuei?
aeanoeaino? ae??aeaeaeiaeo aeiaaaie ye cai?ithaa/?a i’ynii? ne?iaeie,
iaa?oiooaaoe niiniae ?o aaaaeaiiy aei oa?/iaeo nenoai, o oiio /ene? aei
neeaaeo eiiiiceoe?e c nooei iieieii;

? noai?eoe aaco aeaieo o?aaeeoe?eieo ? iiaeo a?eieai?nieo ne?iaeiieo
eiiiiiaio?a, aaeaiooaaoe ?nioth/? iaoaiaoe/i? caniae aeey aiae?oe/iiai
iiaeaethaaiiy i?iaeoeo?a caaeaiiai neeaaeo, ?aae?coaaoe ?o o aeaeyae?
eiii’thoa?ii? i?ia?aie;

? ca aeiiiiiaith eiii’thoa?ii? i?ia?aie ni?iaeooaaoe ?aoeaioo?e oa
cae?enieoe ae?iaieoeoai ia?o?e iiaeo aeae?a i’ynieo eiia?iiaaieo oa?o?a
? iaooao?a c aeei?enoaiiyi oa?/iaeo aeiaaaie (ae??aeaeaeiaeo aeiaaaie oa
-ea?ioeia a eiai ie?eiiio ?ic/ei?), ca i?aaiieaioe/ieie iieacieeaie
aea?aoe iaee?au? c?acee;

? aeaoe oiaa?iciaa/o ioe?ieo yeino? i’ynieo eiina?a?a iioeiaeueieo
?aoeaioo?, aecia/eoe ?o aiaaie?/io aoaeoeai?noue a oiiaao in vitro;

? anoaiiaeoe oa aeine?aeeoe no?ee?noue iiaeo eiia?iiaaieo i’ynieo
eiina?a?a i?e caa??aaii? ;

? ?ic?iaeoe ii?iaoeaio aeieoiaioaoe?th ia eiia?iiaai? i’yni? oa?o oa
iaooao aeey ?aoe?iiaeueiiai oa?/oaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Ia aac? nenoaiiiai aiae?co
no/anieo iieiaeaiue ioo??oe?ieia?? ?ic?iaeaii iaoeiaa caaacia/aiiy
(i?aea?? e?eoa???a iioei?caoe?? c a?aoiaioaoe??th canoinoaaiiy oa
o?aooaaiiyi ?oiuei? ???a?o?? o caaaeuei?e noeoiiino?)
aaaaoiooieoe?iiaeueii? eiii’thoa?ii? i?ia?aie aeey iioei?caoe?? neeaaeo
?nioth/eo oa iiaeaethaaiiy iiaeo ?aoeaioo? i?iaeoeo?a ?c caaeaiei
iaai?ii niiaeea/eo oa?aeoa?enoee.

Iaoeiai iaa?oioiaaii iiaeeea?noue oa aeioe?euei?noue caeo/aiiy aei
oi?ioaaiiy oa?/iaiai ?aoe?iio ethaeeie (ia i?eeeaae? i’ynieo eiina?a?a)
ae??aeaeaeiaeo aeiaaaie: oa?/iaiai a?eeiaiai eiioeaio?aoo,
a?oai?i?ciaaiiai a?eeiaiai i?iaeoeoo — c iaoith ei?aeooaaiiy
a?eeiai-i?ia?aeueiiai i?io?eth i?iaeoeo?a; ae??aeaeaeiaiai aeno?aeoo,
e??i oiai, — ye niaeiai? aeiaaaee.

Anoaiiaeaii aeioe?euei?noue ii?aeiaiiy ae??aeaeaeiaeo aeiaaaie c
iiei/iith ne?iaeiith, aethoaiaoii eae?y o neeaae? oa?/iaeo eiiiiceoe?e
ii-

e?oe?eueiaiai i?ecia/aiiy, ui i?aeoaa?aeaeaii iiceoeaiei ??oaiiyi
IAeOeIA i?i aeaea/o iaoaioo (IIE 6 A 23 L 1/228, A 23 J 1/18 a?ae
11.03.99 ?).

Aeiaaaeaii aoaeoeai?noue cai?iaaaeaeaiiy no?aoaa?/iiai i?iaeooaaiiy
?aoeaioo?iiai neeaaeo i?iaeoeo?a oeyoii eiii’thoa?iiai iiaeaethaaiiy
aeey io?eiaiiy eiia?iiaaieo i’ynieo oa?oo oa iaooaoo ?c caaeaiei
eiiieaenii iiceoeaieo aeanoeainoae.

Aia?oa aeaia oiaa?iciaa/a oa?aeoa?enoeea oa anoaiiaeaii caeiiii??iino?
ci?i yeino? a i?ioean? caa??aaiiy eiia?iiaaieo i’ynieo eiina?a?a c
ae??aeaeaeiaeie aeiaaaeaie, ?aoeaioo?e yeeo ni?iaeoiaai? AII.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeaii iai?yiie
canoinoaaiiy ae??aeaeaeiaeo aeiaaaie, io?eiaieo o ?acoeueoao?
eiiieaenii? ia?a?iaee ae??aeaeae?a-naoa?ii?oeao?a nie?oiaiai
ae?iaieoeoaa, aeey aeaioiaeaiiy eiia?iiaaieo i’ynieo eiina?a?a
«i?eoe?eueii?» yeino?.

?ic?iaeaii ? caoaa?aeaeaii ii?iaoeaio aeieoiaioaoe?th ia iia? i’yni?
eiina?ae («Oa?o nineni/iee «Iiaee» OO O01566117.004-97 oa «Iaooao
«Eaooai» OO O01566117.002-97) oa iiei/ii-ae??aeaeaeiao eiiiiceoe?th (OO
O 22845092.008-99), ye? ai?iaaaeaeai? a?aeiia?aeii ia CAO «Ee?anueeee
i’ynieiia?iao» oa AAO «Aa?nueeee caaiae NCI».

?ic?iaeaii eiii’thoa?io i?ia?aio, yea iiaea aeei?enoiaoaaoeny: 1) ye
aeia?aeiee c o?aaeeoe?eieo ? iiaeo ne?iaeiieo eiiiiiaio?a c
oa?aeoa?enoeeith ?oiuei? oa?/iai? oa a?ieia?/ii? oe?iiino?; 2) aeey
aiae?oe/iiai i?iaeooaaiiy iiaeo ?aoeaioo? i?iaeoeo?a, ye?noue yeeo
iaeneiaeueii iaaeeaeaia aei no/anieo iieiaeaiue oai??? ?aoe?iiaeueiiai
oa?/oaaiiy; 3) aeey ei?aeooaaiiy neeaaeo ?nioth/eo ?aoeaioo?. I?ia?aia
iiaea canoiniaoaaoeny a i?aeoe/i?e ae?yeueiino? i?iieneiaeo oa
oi?aiaaeueieo i?aei?e?inoa, iaoeiaeo onoaiia, o iaa/aeueiiio i?ioean?
i?e i?aeaioiaoe? oao?aoe?a iiai? oi?iaoe?? aeey oi?a?ae? oa oa?/iai?
i?iieneiaino?.

Iniaenoee aianie caeiaoaa/a iieyaa? o oai?aoe/iiio iaa?oiooaaii? oeyo?a
iioei?caoe?? i’ynieo nenoai, ?ic?iaoe? ?aoeaioo? oa ii?iaoeaii?
aeieoiaioaoe?? ia eiia?iiaai? i’yni? oa?o oa iaooao,
iiei/ii-ae??aeaeaeiao eiiiiceoe?th, aeai?? iaoiae?a oa i?iaaaeaii?
aeine?aeaeaiue ia’?eo?a aenia?eiaioo, ia?iaoe? oa nenoaiaoecaoe??
iaea?aeaieo ?acoeueoao?a, ?ic?iaoe? iaoaioo. Aaoi? a?aa aaciina?aaeith
o/anoue o i?iieneia?e ai?iaaoe?? iiaeo eiia?iiaaieo i’ynieo eiina?a?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? ?acoeueoaoe aeine?aeaeaiue
aoee aeeeaaeai? e iaaiai?ai? ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo:
«Iaaeeei-a?ieia?/i? aniaeoe ?ic?iaee i?iaeoeo?a oa?/oaaiiy» (Ee?a, EOA?,
1993 ?.); «Iooe ?aoaiey i?iaeaiu ieuaaiai aaeea a Oe?aeia» (n
iaaeaeoia?iaeiui o/anoeai), (Eeaa, EOYE, 1994 ?.); «?ic?iaea oa
ai?iaaaeaeaiiy i?ia?aneaieo oaoiieia?e oa iaeaaeiaiiy o oa?/iao oa
ia?a?iaio i?iieneia?noue» (Ee?a, OAeOOO, 1995 ?.); «Iaoeia? ? i?eeeaaei?
i?iaeaie oiaa?iciaanoaa a ?eieiaeo oiiaao», (Ee?a, EAeOAO, 1996 ?.),
«Oiaa?iciaanoai — iaoea, i?aeoeea oa ia?niaeoeae ?icaeoeo a oiiaao
?eieo» (c i?aeia?iaeiith o/anoth) (Ee?a, EAeOAO, 1999?.), a oaeiae ia
iaoeiaeo eiioa?aioe?yo i?ioani?nueei-aeeeaaeaoeueeiai neeaaeo EAeOAO,
1996-1998 ??.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 14 iaoeiaeo ?ia?o,
o oiio /ene? io?eiaii ??oaiiy (IIE 6 A 23 L 1/228, A 23 J 1/18) a?ae
IAeOeIA 11.03.99 ?. i?i aeaea/o iaoaioo ia aeiao?ae ca cayaeith ?
98031088 a?ae 03.03.98.

No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?eia ?iaioa neeaaea?oueny c?
anooio, iaeyaeo e?oa?aoo?e, aenia?eiaioaeueii? /anoeie ?iaioe, yea
aeeeaaeaia o 5 ?icae?eao, aeniiae?a, nieneo aeei?enoaii? e?oa?aoo?e ?
aeiaeaoe?a.

?iaioa aeeeaaeaia ia 140 noi??ieao eiii’thoa?iiai oaenoo, ?ethno?iaaia
45 oaaeeoeyie, 13 ?enoieaie ? i?noeoue 19 aeiaeaoe?a. Nienie e?oa?aoo?e
aeeth/a? 188 ?ia?o, c ieo 57 ca?oa?aeieo aaoi??a.

INIIAIEE CI?NO ?IAIOE

O anooi? iaa?oioiaaii aeooaeuei?noue oaie ? iai?yiee aeine?aeaeaiue.

O ia?oiio ?icae?e? «OAIAeAIOe?? ?ICAEOEO ?IAeONO??? OA?*IAEO I?IAeOEO?A»
?icaeyiooi iniiai? iai?yiee aaeineiiaeaiiy yeino? i?iaeoeo?a oa?/oaaiiy,
ye? iia’ycai? c caeo/aiiyi aiae?oe/ieo iaoiae?a i?iaeooaaiiy i?iaeoeo?a
caaeaiiai neeaaeo ia iniia? i?ia?aiiiai caaacia/aiiy, a oaeiae c
?icaeoeii ae?iaieoeoaa iiaeo oa?/iaeo aeiaaaie, ca ?aooiie yeeo iiaeeeaa
oaeineiiaeaiiy niiaeea/eo aeanoeainoae, cieaeaiiy nia?aa?oino?,
?icoe?aiiy ne?iaeiii? aace oa ani?oeiaioo i?iaeoeo?a oa?/oaaiiy.

O ae?oaiio ?icae?e? «AENIA?EIAIOAEUeIA *ANOEIA ?IAIOE» aeaia
oa?aeoa?enoeea ia’?eo?a oa iaoiae?a aeine?aeaeaiue, iaaaaeaii noaio
iinoaiiaee aenia?eiaioo.

Aeine?aeaeaiiy i?iaiaeeeenue ia eaoaae?? oiaa?iciaanoaa oa aenia?oece
i?iaeiaieue/eo oiaa??a EAeOAO, a Oe?a?inueeiio IAe? nie?oo ?
a?ioaoiieia?? i?iaeiaieue/eo i?iaeoeo?a, a Oe?a?inueeiio IAe? oa?/oaaiiy
IIC Oe?a?ie, nai?oa?ii-ai?aeai?ieia?/i?e noaioe?? i. A?iaa?e Ee?anueei?
iaeano?.

Ia’?eoaie aeine?aeaeaiue aoee ae??aeaeaeia? aeiaaaee, ye? io?eiai?
oao?aoeyie Oe?IAe?nie?oa?ii?iae aiane?aeie aaca?aeo?aeii? eiiieaenii?
ia?a?iaee oe?aiiaea?nueeeo ae??aeaeae?a Saccharomyces cerevisiae (i?ae
iaoeiaei ea??aieoeoaii ae.o.i. ssi/aanueeiai A.E.) — oa?/iaee a?eeiaee
eiioeaio?ao (OAE), a?oai?i?ciaaiee a?eeiaee eiioeaio?ao (AAE),
ae??aeaeaeia? aeno?aeoe (AeA-1 c iaeo?ae?caoe??th NaOH ? AeA-2 — KOH );
eiiiiceoe?? ia ?o iniia? — iiei/ii-ae??aeaeaeiaa (IAeE) c nooei
ciaaee?aiei iieieii oa a?ieia?/ii-aeoeaia (AAE) c aethoaiaoii eae?y; a
oaeiae, eiia?iiaai? i’yni? eiina?ae — oa?o oa iaooao, ?aoeaioo?e yeeo
?ic?iaeaii ca aeiiiiiaith noai?aii? eiii’thoa?ii? i?ia?aie, aeaioiaeai?
c aeei?enoaiiyi iacaaieo aeiaaaie ? eiiiiceoe?e. A aenia?eiaio?
canoiniaoaaee -ea?ioei a ie?eiiio ?ic/ei?.

Eiio?ieai neoaeeee: aeey ae??aeaeaeiaeo aeiaaaie — ni?aee a?eeiaee
eiioeaio?ao oa i’yni yeiae/a; aeey oa?o?a — c?acee oa?oo «Eiaaaniee
oa?o ethaeoaeuenueeee» ca AINO 12297; aeey iaooao?a — c?acee iaooaoo
«Ia/?ieiaee» ca AINO 12319.

Aoaie aeine?aeaeaiue i?aaenoaaeai? ia ?en. 1.

I?e aeeiiaii? aeena?oaoe?eii? ?iaioe aecia/aee: i?aaiieaioe/i? iieacieee
(1) — naini?iei aiae?cii ca 5-oe aaeueiith oeaeith; ai?no nooeo ?a/iaei
(2) — a?a?o?aaeiei iaoiaeii; ai?no a?eea (3) — iaoiaeii Eue?eueaeaey c
eiao?oe??ioii ia?a?aooieo 6,25; a?eeiaee acio (4) — ca iaoiaeii
Aa?iooaeia-Ooooea?a; iaa?eeiaee acio (5) — ye ??cieoeth i?ae caaaeueiei
? a?eeiaei acioii; ai?iieeneioiee neeaae a?eea (6) — o?iiaoia?ao?/iei
iaoiaeii ca aeiiiiiaith aaoiiaoe/iiai

aiae?caoi?a ai?iieeneio AAA 339I (*ao?y); ai?no o?eioioaio (7) ?
ienei?ie?io (8) — eiei?eiao?e/iei iaoiaeii; ai?no ioeea?iiaeo eeneio (9)
— niaeo?ioioiiao?e/iei iaoiaeii; ai?no aee?o (10) — aeno?aeoe?eiei
iaoiaeii a aia?ao? Nieneaoa; neeaae aee?ieo eeneio (11) — ca aeiiiiiaith
aaciaiai o?iiaoia?aoa ia?ee «O?ii-5» (*ao?y); ai?no ciee (12) — nooei
icieaiiyi i?e oaiia?aoo?? (400-600)N; ai?no eae?th ? iao??th (13) — ca
aeiiiiiaith iieoi’yiiai oioiiao?a; eaeueoe?th ? iaai?th (14) —
eiiieaeniiiiao?e/iei iaoiaeii ca aeiiiiiaith o?eeiio A; cae?ca (15) —
eiei?eiao?e/iei iaoiaeii c i?oioaiaio?ie?iii; oinoi?o (16) —
o?iie?i-iie?aaeaoiei iaoiaeii; aaaee? iaoaee (17) — iaoiaeii
aoiiii-aani?aoe?eii? niaeo?ineii?? ia niaeo?ioioiiao?? «IITACHI-8000»;
ai?no eooiiii? nie? (18) — ca AINO 8756.20-70; a?oai?ie A1 ? A2 (19) —
oethi?iiao?e/iei iaoiaeii; i??eaeienei (20) — i?e?ia?ieia?/iei iaoiaeii;
i?aoeei (??) (21) — eiei?eiao?e/iei ?iaeai-a?ii?aeiei iaoiaeii;
oieioa?ie (A), ?aoeiie (A) ? -ea?ioei (22) — eiei?eiao?e/iei iaoiaeii;
ai?no aoaeaaiae?a (23): a) ?aaeoeoth/eo oeoe??a — iaoiaeii Aa?o?aia, a)
e?ioiaeth — ca AINO 7699-78; iieacieee yeino? aee?o (24): eeneioia /enei
— ia’?iiei iaoiaeii; ia?aeenia /enei — ?iaeiiao?e/iei iaoiaeii;
o?iaa?a?oo?iaa /enei — eiei?eiao?e/iei iaoiaeii; ?aieia?/i? iieacieee
i’ynieo eiina?a?a (25): aoaeoeaio a’yce?noue — ia i?eeaae? «?aioano-2»;
ieanoe/i?noue — i?anoaaiiyi; aa?iaoe/i?noue iaoaeaaeo aaiie (26) — ca
AINO 5981-88; aieiaica’ycoth/o caeaoi?noue (ACC) (27) — ca iaoiaeii
A?ao ?. ? Oaii ?. a iiaeeo?eaoe?? Aieia?inueei? A.I. ? Eaeueiaia A.ss.;
aiaaie?/io aoaeoeai?noue a oiiaao in vitro (28) — ca iaoiaeii
Iie?ianueeiai I.I. ? ??oaiiaa ?.O.; i?e?ia?ieia?/i? iieacieee (29) — ca
AINO 10444.1-85, AINO 10444.3-10444.5; ?ioaa?aeueiee iieaciee yeino?
(30) — ca aeiiiiiaith iaoiae?a eaae?iao???; ooieoe?iiaeuei? aeanoeaino?
ae??aeaeaeiaeo aeiaaaie (31):

?ic/eii?noue o aiae? (?OA), nooi?iue iaaooaiiy o aiae? ? aee??
(a?aeiia?aeii NIA ? NIAE), aiaeioo?eioth/o (AOC), aee?ioo?eioth/o
(AEOC), aioeueaoth/o oa i?iiooai?thth/o caeaoiino?. Aeine?aee ? aiae?ce
i?iaiaeeeenue o o?ueio-i’yoee?aoi?e iiaoi?iino?. ?acoeueoaoe
aeine?aeaeaiue ia?iaeaii ca aeiiiiiaith iaoiae?a iaoaiaoe/ii?
noaoenoeee.

O o?aoueiio ?icae?e? «IOe?IEA ssEINO? Ae??AEAeAEIAEO AeIAAAIE, IO?EIAIEO
C OE?AIIAEA?NUeEEO Ae??AEAeAE?A NIE?OIAIAI AE?IAIEOeOAA» aeeeaaeaii
?acoeueoaoe aeine?aeaeaiiy ai?noo iniiaieo iae?iiiaeeaieo ?a/iaei o
ae??aeaeaeiaeo aeiaaaeao (?en.2), ye? na?ae/aoue, ui

?en.2. O?i?/iee neeaae ae??aeaeaeiaeo aeiaaaie, ni?aiai a?eeiaiai
eiioeaio?aoo (NAE) ? yeiae/iai i’yna

ii??aiyii ?c ni?aei a?eeiaei eiioeaio?aoii (NAE) aiie i?noyoue aaeeeo
e?euee?noue a?ee?a, iecueeo — aee?o ? iaeaea iaeiaeiao — aoaeaaiae?a. O
oa?/iaiio ? a?oai?i?ciaaiiio a?eeiaeo eiioeaio?aoao a?eea iaeaea a 3
?ace, a a ae??aeaeaeiaeo aeno?aeoao — a 1,4 ?aca a?eueoa, i?ae a
yeiae/iio i’yn?. Ca ai?noii i?ia?aeueieo aeaiaio?a a?eeia? eiioeaio?aoe
ia a?ae??ciythoueny a?ae ni?aiai eiioeaio?aoo ? ia?aaa?oothoue yeiae/a
i’yni. Cia/ia /anoea i?ia?aeueieo ?a/iaei o ae??aeaeaeiaeo aeno?aeoao
coiiaeaia oaoiieia??th ?o ae?iaieoeoaa (caaaa/aiiyi eae??i, iao???i,
eaeueoe??i).

Iaaaaeai? aeai? ? aiae?c ai?iieeneioiiai neeaaeo ae??aeaeaeiaeo aeiaaaie
(?en.3) iieacothoue

?en.3. Ai?iieeneioiee neeaae ae??aeaeaeiaeo aeiaaaie

aeioe?euei?noue ?o canoinoaaiiy i?e noai?aii? iiai? oa?/iai?
eiiiiceoe??, a oaeiae aeey ei?aeooaaiiy neeaaeo o?aaeeoe?eieo ae?ia?a.

A?aei?iiith iniaeea?noth an?o ae??aeaeaeiaeo aeiaaaie ? i?aeaeuaiee
ai?no o?eioioaio, aae?io, e?ceio, a oaeiae a OAE ? AAE — eaeoeeio ?
o?aii?io, a AeA — a?iiaoe/ieo ai?iieeneio. Aeao?oeeoieie aeey
ae??aeaeaeiaeo a?ee?a ? n??eoai?ni? ai?iieeneioe, ca ai?noii ?ioeo
iacai?iieo ai?iieeneio aiie iaaeeaeathoueny aei ai?iia?aie i’yna.

O neeaae? i?ia?aeueieo ?a/iaei ae??aeaeaeiaeo aeiaaaie aeyaeaiee oe?ieee
niaeo? iae?i- ? i?e?iaeaiaio?a, na?aae yeeo cia/ia e?euee?noue eae?th,
oinoi?o, eaeueoe?th, iaai?th oa cae?ca. Ca ai?noii oiene/ieo aeaiaio?a
ae??aeaeaeia? aeiaaaee a?aeiia?aeathoue «Iaaeeei-a?ieia?/iei aeiiaai ?
nai?oa?iei ii?iai yeino? i?iaeiaieue/i? ne?iaeie ? oa?/iaeo i?iaeoeo?a»,
? 5061-89.

A?oai?i?ciaaiee a?eeiaee eiioeaio?ao oa ae??aeaeaeia? aeno?aeoe iathoue
cia/io a?oai?iio oe?ii?noue ca ?aooiie aaeeei? e?eueeino? a?oai?i?a
a?oie A ? i?aoeeio.

I?e aea/aii? ooieoe?iiaeueieo aeanoeainoae (?en.4, ?en.5)
ae??aeaeaeiaeo aeiaaaie anoaiiaeaii, ui aiie ? oaoiieia?/ii i?eaeaoieie
aeey oa?/iai? i?iieneiaino?.

?en. 4. Ooieoe?iiaeuei? aeanoeaino? ae??aeaeaeiaeo aeiaaaie

A
A

?en. 5. Aioeueaoth/a (A) oa i?iiooai?thth/a (A) caeaoiino?
ae??aeaeaeiaeo aeiaaaie

Ai?iaaoe?y ??cieo niinia?a aaaaeaiiy aeiaaaie aei oa?o?a oa iaooao?a
iieacaea, ui iaea?eueo ?aoe?iiaeueiei, c oaoiieia?/ii? oi/ee ci?o, ?
iinoaae?eia aianaiiy iaaaeeeeo ii?oe?e ae??aeaeaeiaeo aeiaaaie o nooiio
aeaeyae?: a?eeiaeo eiioeaio?ao?a — ia ia?o?e noaae?? eooa?oaaiiy
iaaee?iiai i’yna, ae??aeaeaeiaeo aeno?aeo?a ye aioeueaaoi??a — ia
ae?oa?e noaae?? ia?iaee ne?iaeie c aenieei ai?noii aee?o. Canoinoaaiiy
OAE ? AeA o aeacai?e iine?aeiaiino? caaacia/o? iioeiaeueiee ?icaeoie
ooieoe?iiaeueieo aeanoeainoae oa?oo (aieiaica’ycoth/o ? aee?ica’ycoth/o
caeaoiino?), i?aeaeuo? noaa?euei?noue eiai eiinenoaioe??.

Ia iniia? nooiai ciaaee?aiiai iieiea ? ae??aeaeaeiaeo aeiaaaie io?eiai?
iiei/ii-ae??aeaeaeia? eiiiiceoe??, ye? ? iie?ooieoe?iiaeueieie
(iie?ioaiiy ai?iieeneioiiai ? i?ia?aeueiiai neeaaeo, iie?auaiiy
canai?iiy oiui) aeiaaaeaie aeey oe?ieiai niaeo?a oa?/iaeo i?iaeoeo?a.
Ia?niaeoeaiei iai?yieii canoinoaaiiy ae??aeaeaeiaeo aeno?aeo?a o
oa?/ia?e i?iieneiaino? noaei noai?aiiy ia ?o iniia? a?ieia?/ii-aeoeaii?
eiiiiceoe??, yea ia?, ie??i cia/iiai ai?noo a?ee?a, i?ia?aeueieo
aeaiaio?a ? a?oai?i?a, no?oeoo?iooai?thth/? aeanoeaino?, caeaoi?noue
iineethaaoe oa a?aeiiaethaaoe niae oa?/iaeo i?iaeoeo?a

O /aoaa?oiio ?icae?e? «?IC?IAEA ?AOeAIOO? OA OIAA?ICIAA*A OA?AEOA?ENOEEA
EIIA?IIAAIEO I’ssNIEO EIINA?A?A CAAeAIIAI O?I?*IIAI NEEAAeO»
i?aaenoaaeai? ?acoeueoaoe iiaeaethaaiiy iioeiaeueieo ?aoeaioo? i’ynieo
i?iaeoeo?a ia iniia? ?ic?iaeaii? eiii’thoa?ii? i?ia?aie c o?aooaaiiyi
oaoiieia?/ieo iniaeeainoae i?eaiooaaiiy i’ynieo eiina?a?a, aiae?co
o?i?/iiai neeaaeo ne?iaeie, ui o?aaeeoe?eii aeei?enoiao?oueny aeey ?o
ae?iaieoeoaa, a oaeiae aeaieo aeine?aeaeaiiue oa?/iai? ? a?ieia?/ii?
oe?iiino?, ooieoe?iiaeueieo aeanoeainoae ae??aeaeaeiaeo aeiaaaie.

E?eoa??yie iioei?caoe??, ye? canoiniaothoueny (o noeoiiino? aai ie?aii)
i?e i?iaeooaaii? ?aoeaioo? i?iaeoeo?a, ?: ni?aa?aeiioaiiy — iacai?iieo
aei cai?iieo ai?iieeneio = 1:1; o?eioioaio aei e?ceio aei
(iao?ii?i+oeenoeio)= 1: (3-5) : (2-4); o?eioioaio aei o?aii?io aei
eaeoeeio = 1 : (2-3) : (4-6); iie?iaiane/aieo aei iiiiiaiane/aieo aei
iane/aieo aee?ieo eeneio = 1:6:3; iae?iaeaiaio?a E : Na = 1:2; Ca : ?
= 1 : (1-1,5); Ca : Ig = 1 : (0,5-0,65) [Niiey? A.?., 1991].
Iniaeeao oaaao i?eae?eaii iaenei?caoe?? cia/aiiy eiao?oe??ioa
aeei?enoaiiy a?eea (), e?eueeino? ooee?co?ieo a?ee?a (?o) /e
eiao?oe??ioo aoaeoeaiino? e?i?ae?a (). I?eeiyoi?noue i?aaiieaioe/ieo
iieaciee?a o?aaeeoe?eiei oyaeaiiyi niiaeeaa/?a aecia/aee i?ney
i?iieneiaeo aei?iaoaaiue c?ace?a eiina?a?a iiaeaeueieo ?aoeaioo?.

Ca ?acoeueoaoaie i?iaaaeaiiai eiii’thoa?iiai iiaeaethaaiiy ?aoeaioo?,
aei?iaoaaiue o i?iieneiaeo oiiaao, a?aeai?o a?oiith aenia?o?a iaea?eueo
i?eeiyoieo ca i?aaiieaioe/ieie iieacieeaie c?ace?a, io?eiaii iioeiaeuei?
?aoeaioo?e eiia?iiaaieo oa?oo oa iaooaoo (oaae. 1).

Iia? eiia?iiaai? i’yni? eiina?ae iaee i?e?iiee niae oa a?iiao, a?eueo
i?aeio eiinenoaioe?th, aoee nieiaeo?oeie ca o?aaeeoe?ei? ae?iae.

Oaaeeoey 1

?aoeaioo?e eiia?iiaaieo i’ynieo oa?oo oa iaooaoo, %

Oa?oIaooaosseiae/eia41,000Ia/?iea yeiae/a
29,95Naeieia i’ynia40,955Na?oea
19,00Ie?eiee ?ic/ei -ea?ioeio1,000Iicie
16,00E?ioiaeue ea?oiieyiee4,000E?ia oe?eueia yeiae/a
25,00Oa?/iaee a?eeiaee eiioeaio?ao2,000Ie?eiee ?ic/ei
-ea?ioeio4,00Ae??aeaeaeiaee aeno?aeo (AeA-1)2,000Ae??aeaeaeiaee
aeno?aeo (AeA-2)2,00N?eue eooiiia1,000N?eue eooiiia
1,00I?o?eo iao??th0,005Ia?aoeue caiaoiee
0,04Ia?aoeue caiaoiee0,040Oeeaoey iana?iaaia 3,00Aiaea
(eueiae)8,000Oeoei?-i?nie 0,01

O ?acoeueoao? eiiieaeniiai aeei?enoaiiy ??ciiiai?oii? ca iioiaeaeaiiyi
ne?iaeie io?eiai? eiia?iiaai? oa?o oa iaooao, ye? aea?aeii
a?ae??ciythoueny a?ae o?aaeeoe?eieo ca nai?i o?i?/iei neeaaeii (oaae.2):
i?noyoue a?eueoo e?euee?noue a?eea (a?aeiia?aeii ia 17,0% ? 13,8%),
i?ia?aeueieo ?a/iaei (ia 4,0% ? 13,3%) ? iaioo — aee?o (ia 24,5% ?
62,8%).

Caaaeyee aeei?enoaiith ae??aeaeaeiaeo aeno?aeo?a, ye? aieiae?thoue
aeanoea?noth iineethaaoe niae oa?/iaeo i?iaeoeo?a, o neeaae?
eiia?iiaaieo i’ynieo eiina?a?a ciaioaii e?euee?noue eooiiii? nie?: o
oa?o? — ia 46,6%, o iaooao? — ia 23,0%. Ca ii??aiyii aeniei? oa?/iai?
oe?iiino? iia? eiina?ae iathoue iecueeo aia?aaoe/io oe?ii?noue (ia 14,
6% ? 41,7% iaioa, i?ae aeey o?aaeeoe?eieo).

Oaaeeoey 2

Iieacieee yeino? eiia?iiaaieo i’ynieo oa?oo ? iaooaoo

n=3

Im

IieacieeOa?oIaooaoeiio?ieue aeine?aeeiio?ieue aeine?aeAi?no (%):

aieiae

58,300,91

60,731,03

69,750,80

72,450,28a?eea12,290,15
14,380,1614,090,3516,040,15aee?o24,380,3118,400,2618,730,21
6,960,14aoaeaaiae?a 2,540,10 3,890,130,950,07
1,740,10ciee2,490,042,590,052,480,05 2,810,04eooiiii?
nie?1,760,050,940,021,260,03 0,970,03?I6,390,02 6,450,046,590,02
6,750,03Aia?aaoe/ia oe?ii?noue 100 a i?iaeoeoo, eAeae

1197,2

1022,3

983,5

573,3

— iayai?noue noaoenoe/ii aeinoia??ieo a?aei?iiinoae (?0,05).

Aenie? ooieoe?iiaeuei? aeanoeaino? ae??aeaeaeiaeo aeiaaaie, ye?, ia
a?aei?io a?ae i’ycaaeo a?ee?a i’yna, no?ee? aei iaa??aaiiy, aeia?a
?ioeueaothoue aee? ? ca’ycothoue aieiao ye aei, oae ? i?ney oa?i?/ii?
ia?iaee, coiiaeee i?aeaeuaiiy aieiaica’ycoth/i? caeaoiino? eiia?iiaaiiai
oa?oo (ia 12,2%), ieanoe/iino? (ia 8,8%) oa cieaeaiiy aoaeoeaii?
a’yceino? (ia 19,6%). Ca ?aooiie ca?eueoaiiy a?ee?a i?aeaeuothoueny
aieiaica’ycoth/a caeaoi?noue (a?aeiia?aeii ia 2,8%), ieanoe/i?noue (ia
13,1%) ? cieaeo?oueny aoaeoeaia a’yce?noue (ia 13,2%) eiia?iiaaiiai
iaooaoo ii??aiyii c o?aaeeoe?eiei. ?acoeueoaoe aeine?ae?a na?ae/aoue i?i
neeueiee ei?aeyoe?eiee ca’ycie i?ae ACC e ieanoe/i?noth o o?aaeeoe?eiiio
? eiia?iiaaiiio c?aceao oa?oo ( eiao?oe??io ia?ii? ei?aeyoe?? r=0,9337 ?
r=0,9950 a?aeiia?aeii). Oaeaae caeaaei?noue ciaeaeaia aeey iaooao?a:
a?eueo neeueia — aeey aeine?aeiiai (r=0,9673) ? neaaoa — aeey
eiio?ieueiiai (r=0,8695).

I?e i?iaeooaaii? neeaaeo eiia?iiaaieo i’ynieo i?iaeoeo?a, ie??i
a?aooaaiiy ai?iieeneioieo nei??a, a yeino? iniiaiiai e?eoa??th
iioei?caoe?? a?eeiaiai i?io?eth aeei?enoiaoaaee eiao?oe??io ?o , yeee
oa?aeoa?eco? iioaioe?eio ni?iiiaei?noue i’ynii? nenoaie caaeiaieueieoe
iio?aao i?aai?cio ethaeeie a a?eeo. O ?acoeueoao? eiia?iiaai? oa?o oa
iaooao ca e?euee?noth iioaioe?eii ooee?co?iiai a?eea ia?aaa?oothoue
o?aaeeoe?ei? ae?iae (a?aeiia?aeii ia 22,6% ? 26,9%), caaaeyee /iio i?e
niiaeeaaii? iiaeo i’ynieo i?iaeoeo?a canaith?oueny iaeneiaeueia
e?euee?noue iacai?iieo ai?iieeneio, i?e oeueiio ?o aeo?aoe ia
eaoaaie?/i? oe?e? — i?i?iaeuei?. Oea ocaiaeaeo?oueny c ?acoeueoaoaie
aiae?co (oaae.3) iniiaieo ni?aa?aeiioaiue iacai?iieo ai?iieeneio (ICAE).

Oaaeeoey 3

Ai?iieeneioiee i?io?eue eiia?iiaaieo i’ynieo eiina?a?a (A — ai?no ICAE,
a ia 100 a a?eea, N — nei? ICAE, %)

Ai?iieeneioaOeaea OAI/AIICOa?oIaooaoeiio?ieue aeine?ae eiio?ieue
aeine?ae
ANANANANAN1234567891011Aae?i5,01005,601125,651136,531316,73135?cieaeoeei
4,01004,381094,341095,171294,07102Eaeoeei7,01007,841127,811128,501219,01
129E?cei5,51008,551558,331517,621398,30151Iao?ii?i+
oeenoei3,51003,33953,521013,611033,61102O?aii?i4,01004,311084,511134,421
104,38110O?eioioai1,01001,191191,371371,271271,34134Oai?eaeai?i+oe?ic?i6
,01007,631277,651288,761468,60143Anueiai ICAE:36,042,8343,1845,8846,04
, /anoea iaeeieoe?0,8000,8380,8090,807 ?o , a ia 100 a i?iaeoeoo

9,83

12,05

11,40

12,94

Oae, o eiia?iiaaiiio oa?o? ni?aa?aeiioaiiy o?eioioaio, e?ceio ? o?aii?io
(1:6,1:3,3) iaeneiaeueii iaaeeaeaia aei ii?i ?aoe?iiaeueiiai oa?/oaaiiy,
a o?eioioaio, eaeoeeio ? n??eoai?nieo ai?iieeneio (1:5,7:2,6) —
iioeiaeueia. Ia??ai? c o?aaeeoe?eiei iiaee aeae iaooaoo ia? aeia?o
caaeainiaai?noue o?eioioaio, o?aii?io ? n??eoai?nieo ai?iieeneio
(1:3,3:2,7) oa o?eioioaio, e?ceio ? eaeoeeio (1:6,2:6,7).

I?aeoaa?aeaeaiiyi aeniei? a?ieia?/ii? aoaeoeaiino? iiaeo aeae?a
eiina?a?a ? aeai?, io?eiai? a aeine?aeao in vitro, ca?aeii c yeeie
oaeaee?noue ? nooi?iue ia?ao?aaeaiiy a?ee?a aeine?aeieo c?ace?a oa?oo
oa?iaioaie oeoieiai-eeoeiaiai o?aeoo aeua, i?ae o?aaeeoe?eieo (oaae.4).
I?ae ae??th oa?iaio?a o eiia?iiaaiiio oa?o? ooai?th?oueny ia 4,3%
a?eueoa ai?iiiai acioo, i?ae o o?aaeeoe?eiiio. Iaeiie/aiiy ai?iiiai
acioo i?e ia?iaoe? oa?iaioaie eiia?iiaaiiai iaooaoo eaea aeaui oaeaeoa.
Aei e?ioey aeine?aeaeaiue caaaeueia eiai e?euee?noue noaiiaeoue 46,48
iiieue ia 1 a a?eea, ui ia 5,1% a?eueoa, ii??aiyii c eiio?ieueiei
c?aceii. I/aaeaeii, oe?eani?yiiaaia ii?aeiaiiy ne?iaeiieo eiiiiiaio?a
i?e iioei?caoe?? eiao?oe??ioa aeei?enoaiiy a?ee?a () oa iaenei?caoe??
ooee?co?ii? e?eueeino? a?eea (?o), a oaeiae i?aeaeuaiiee ai?no
caaaeueii? e?eueeino? a?ee?a ca ?aooiie aeei?enoaiiy ae??aeaeaeiaeo
aeiaaaie aecia/athoue aenieo aoaeoeai?noue ooee?caoe?? i’ynieo
i?iaeoeo?a aeine?aeieo ?aoeaioo?. Oea ocaiaeaeo?oueny c a?iioacith
Iie?ianueeiai I.I. oa noaa?aeaeaiiyie aaaaoueio no/anieo iaoeiaoe?a
(I?eiea?anueea A.?., sseeiianueeee I.I., *a?i?eia I.I.) i?i iie?ioaia
canai?iiy eiia?iiaaieo i?iaeoeo?a, o yeeo ii?aeiothoueny a?eee ??ciiai
iioiaeaeaiiy.

Oaaeeoey 4

Ia?ao?aaeaiiy in vitro i?ioa?i?a eiia?iiaaieo i’ynieo eiina?a?a (iiieue
ai?iiiai acioo ia a a?eea)

n=5

Mm

Iacaa

i?iaeoeooNoaae?? i?ioaie?coCaaaeueiee
i?ioaie?ciaineiiaao?eineiiaaiaio?aeaciaOa?oEiio?ieue
4,280,2718,930,8520,830,2844,040,65Aeine?ae4,050,1720,010,3921,870,4545,
930,96IaooaoEiio?ieue
4,920,3819,170,4220,130,6144,220,98Aeine?ae3,310,96 21,120,51
22,050,3846,480,85

— iayai?noue noaoenoe/ii aeinoia??ieo a?aei?iiinoae (?0,01).

Anoaiiaeaii, ui aeei?enoaiiy a yeino? ?aoeaioo?iiai eiiiiiaioa oe?eueii?
e?ia? caa?eieo oaa?ei o ii?aeiaii? c ae??aeaeaeiaith aeiaaaeith
aeicaiey? ae?iaeyoe iaooaoe, ye? ca nai?i ai?iieeneioiei neeaaeii ?
a?ieia?/ii iiaiioe?iieie.

?acoeueoaoe aiae?co i?ia?aeueiiai neeaaeo na?ae/aoue, ui iia? i’yni?
eiina?ae i?noyoue cia/io e?euee?noue eae?th, iao??th, eaeueoe?th,
oinoi?o oa iaai?th o ni?aa?aeiioaiiyo, iaeneiaeueii iaaeeaeaieo aei
iioeiaeueieo. Oae, aeey iiaeo aeae?a oa?oo oa iaooaoo ni?aa?aeiioaiiy
i?ae eae??i oa iao???i noaiiaeoue — 1:1,9 ? 1:1, oiae? ye aeey
o?aaeeoe?eieo — 1:2,9 ? 1:2,3 a?aeiia?aeii. O aeine?aeieo c?aceao c?
cieaeaiei ai?noii aee?o iie?auo?oueny ni?aa?aeiioaiiy i?ae eaeueoe??i ?
iaai??i (1:0,6 , ii??aiyii c o?aaeeoe?eieie c?aceaie oa?oo ? iaooaoo
1:1,2 ? 1:1 a?aeiia?aeii), ui iaoiiaeth? iie?ioaia canai?iiy
eaeueoe?th. Aeei?enoaiiy ae??aeaeaeiaeo aeiaaaie o neeaae? i’ynieo
eiina?a?a cia/ii iie?ioo? ni?aa?aeiioaiiy eaeueoe?e:oinoi?: a?ae 1:9 —
o eiio?ieueiiio c?aceo oa?oo aei 1:1,9 — o aeine?aeiiio; a?ae 1:17
aei 1:3 — o iaooao?.

Oa?o oa iaooao iiaeo ?aoeaioo? oa?aeoa?ecothoueny aenieei nooiaiai
caaeiaieaiiy iio?aae o i?ia?aeueieo ?a/iaeiao: i?e niiaeeaaii? 350 a
eiia?iiaaiiai oa?oo ia aeiao iaeaea iaiieiaeio caaeiaieueiy?oueny
iio?aaa o oinoi??, eae??, iaai?? ? iiai?noth — o cae?c?.

Aeniea a?ieia?/ia oe?ii?noue eiia?iiaaieo i’ynieo eiina?a?a
aecia/a?oueny ?o aaaaoei a?oai?iiei neeaaeii. Ca ?aooiie aeei?enoaiiy
ae??aeaeaeiaeo aeiaaaie oa ie?eiiai ?ic/eio -ea?ioeio o aeine?aeieo
c?aceao eiina?a?a, a ii??aiyii? c eiio?ieueieie, cao?eniaaii i?aeaeuaiiy
??aiy a?oai?i?a a?oie A, -ea?ioeio oa oieioa?ieo. Eiia?iiaai? oa?o oa
iaooao (ii?oe?y 350 a) caaacia/othoue a?eueoa 50% o?c?ieia?/ii? ii?ie
o?ai?io, i??eaeieneio, i?aoeeio. Uia caaeiaieueieoe iio?aao o
?eaioeaa?i?, -ea?ioei? ? ?aoeiie? aeinoaoiuei niiaeeaaoe 140 a iaooaoo
ia aeiao.

Ia a?aei?io a?ae o?aaeeoe?eieo eiina?a?a, eiia?iiaaiee oa?o oa iaooao
i?noyoue iaioo e?euee?noue aee?ieo eeneio (ia 7,9% ? 12,0% ca noiith
a?aeiia?aeii), a?eueoo — iie?iaiane/aieo aee?ieo eeneio (ia 20,9% aeey
oa?oo, a 1,6 ?aco — o iaooao?).

Ca ?ioaa?aeueiei iieacieeii yeino?, yeee a?aoiao? ia o?eueee
a?aeoeeaiiy a?ae ii?iaoeaiiai cia/aiiy ia?aiao?a i?iaeoeoo, aea e
aaaii?noue eiaeiiai c ieo o caaaeuei?e noeoiiino?, iia? eiia?iiaai? oa?o
oa iaooao ia?aaa?oothoue a?aeiia?aeii ia 15,6% ? 17,1% o?aaeeoe?ei?.

I???ioiaia aeiiii?/ia aoaeoeai?noue a?ae ae?iaieoeoaa oa ?aae?caoe??
iiaeo eiia?iiaaieo eiina?a?a c ae??aeaeaeiaeie aeiaaaeaie a oe?iao ia 1
i?a??//y 1996 ?ieo noaiiaeoue 300,7 a?i. ? 342,5 a?i. ia 1 ooao
eiia?iiaaieo oa?oo oa iaooaoo a?aeiia?aeii.

I’yoee ?icae?e «AEA*AIIss NO?EEINO? EIIA?IIAAIEO I’ssNIEO EIINA?A?A AeI
CAA??AAIIss» i?enay/aiee aeine?aeaeaiith yeino? i’ynieo eiina?a?a o
i?ioean? caa??aaiiy i?e oaiia?aoo?? 182N ? a?aeiini?e aieiaino? iia?o?y
ia a?eueoa 75% i?ioyaii 12 i?nyoe?a.

Anoaiiaeaii, ui ai?iaeiaae onueiai oa?i?io caa??aaiiy i?aaiieaioe/i?
iieacieee eiina?a?a iaeaea ia ci?ithaaeenue, ciai?oiy ? aioo??oiy
iiaa?oiy aaiie caeeoaeanue iaooeiaeaeaiith.

O i?ioean? caa??aaiiy a?aeaoaaeenue caeiiii??i? ci?ie ieanoe/iino? ?
aieiaica’ycoth/i? caeaoiino? eiia?iiaaieo i’ynieo eiina?a?a, ye?
i?io?eaee c iaioith ?ioaineai?noth, ii??aiyii c o?aaeeoe?eieie, ui
coiiaeaii, ia iaoo aeoieo, iayai?noth a ?o neeaae? ae??aeaeaeiaeo
aeiaaaie, caeaoieo aeia?a oo?eioaaoe a?eueio aieiao a i’ynieo nenoaiao.

A?aecia/aii iinooiiaa i?aeaeuaiiy aoaeoeaii? a’yceino? ye aeey
eiio?ieueieo, oae ? aeey aeine?aeieo c?ace?a i’ynieo eiina?a?a. Oae,
iai?ee?ioe? caa??aaiiy aoaeoeaia a’yce?noue eiio?ieueiiai c?acea oa?oo
ia?aaeuoaaea aeo?aeia cia/aiiy oeueiai iieacieea ia 1,6%, aeine?aeiiai
c?acea — ia 1,0%; a c?aceao iaooaoo — ia 1,0% ? 1,4% a?ae ii/aoeo
caa??aaiiy.

I?e caa??aaii? i?ioyaii iaeiiai ?ieo a?aeaoaaeenue caeiiii??i? ci?ie o
neeaae? acioieo o?aeoe?e: iinooiiaa cieaeaiiy ai?noo a?eeiaeo ?a/iaei ?
i?aeaeuaiiy — iaa?eeiaeo acioieo niieoe. Aei e?ioey caa??aaiiy
e?euee?noue a?eeiaiai acioo ciaioeeanue o eiio?ieueieo c?aceao oa?oo oa
iaooaoo a?aeiia?aeii ia 2,9% ? 3,0%, o aeine?aeieo — ia 2,4% ? 2,6%.

O i?ioean? caa??aaiiy ci?ithaaany ai?iieeneioiee neeaae i’ynieo
eiina?a?a, ui iaoiiaeaii ae??th oa?iaio?a, aca?iiae??th a?ee?a c
aoaeaaiaeaie oa aee?aie. Aei e?ioey caa??aaiiy eiia?iiaaieo oa?oo ?
iaooaoo cao?eniaaii ciaioaiiy ai?noo ai?iieeneio a?aeiia?aeii ia 2,3% ?
1,7% a?ae ?o caaaeueii? noie ia ii/aoeo aeine?aeaeaiue.

Iaio ?ioaineaii, i?ae o eiio?ie?, a?aeaoaaeenue ci?ie o aee?iieeneioiiio
neeaae? aeine?aeieo c?ace?a oa?oo oa iaooaoo. Oae, i?ney 12 i?nyoe?a
caa??aaiiy e?euee?noue iie?iaiane/aieo aee?ieo eeneio o eiia?iiaaieo
oa?o? oa iaooao? ciaioo?oueny ia 21,1% ? 18,2%, oiae? ye o o?aaeeoe?eieo
ae?iaao — ia 33,3% ? 20,6% a?aeiia?aeii. I/aaeaeii, oea iaoiiaeaii
?ia?a??oth/ith ae??th oaeeo ?a/iaei, ye ai?iieeneioe, oieioa?ie,
ea?ioei, ??aaiue yeeo o aeine?aeieo c?aceao aeuee.

A i?ioean? caa??aaiiy eoei iia?eueia iaeiie/aiiy i?iaeoeo?a ieeneaiiy
e?i?ae?a o eiio?ieueieo oa aeine?aeieo c?aceao eiina?a?a (?en. 7).

?en. 7. Aeeiai?ea ci?i eeneioiiai ? ia?aeeniiai /enae aee?o eiia?iiaaieo
i’ynieo eiina?a?a

Ca ?acoeueoaoaie aecia/aiiy aoi?eiieo i?iaeoeo?a ieeneaiiy, ye?
?aaaothoue c 2-o?iaa?a?oo?iaoth eeneioith, anoaiiaeaii, ui i?ioyaii
anueiai oa?i?io caa??aaiiy ieenethaaeuei? i?ioeane i?io?eaee iia?eueii.

O i?ioean? caa??aaiiy ai?no iacio?eueieo aa?iaieo ?
oaeoeueoaoeaii-aiaa?iaieo i?e?ii?aai?ci?a a?aeiia?aeaa ii?i?, a on?o
c?aceao aoee a?aenooi? aaeoa??? a?oie eeoeiai? iaee/ee (eie?oi?ie),
iaoiaaii? i?e?ii?aai?cie, a oiio /ene? Naeueiiiaee, i?ioath ?
eiaaoeaciiiceoeai? noao?eieiee.

AENIIAEE

1. C iaoith aeeth/aiiy a i’yni? i?iaeoeoe ae??aeaeaeiaeo aeiaaaie,
io?eiaieo c oe?aiiaea?nueeeo ae??aeaeae?a Saccharomyces cerevisiae,
i?iaaaeai? ?o eiiieaeni? aeine?aeaeaiiy, a oiae? yeeo aeyaeaii aenieee
ai?no a?ee?a, i?ia?aeueieo ?a/iaei oa a?oai?i?a. Anoaiiaeaii, ui oa?/ia?
a?eeia? eiioeaio?aoe c ae??aeaeae?a ca ai?iieeneioiei neeaaeii
iaaeeaeathoueny aei i’yna ? iiaeooue noaoe cai?iieeaie oe??? oe?iii?
ne?iaeie o neeaae? iiaeo i?iaeoeo?a. Caaaeath/e ia ?acoeueoaoe aea/aiiy
ooieoe?iiaeueieo aeanoeainoae ae??aeaeaeiaeo aeiaaaie aecia/aii, ui
iaeaeioe?euei?oei ? aeei?enoaiiy oa?/iaiai oa a?oai?i?ciaaiiai a?eeiaeo
eiioeaio?ao?a ye iaiiaithaa/a, aieiai- oa aee?ica’ycoth/iai oaeoi?a,
ae??aeaeaeiaeo aeo?aeo?a — a yeino? aioeueaaoi?a.

2. C aeei?enoaiiyi ae??aeaeaeiaeo aeiaaaie noai?aii
iiei/ii-ae??aeaeaeiao (OO O 22845092.008-99) oa a?ieia?/ii-aeoeaio
eiiiiceoe?? (??oaiiy IAeOeIA i?i aeaea/o iaoaioo — IIE 6 A 23 L 1/228, A
23 J 1/18 a?ae 11.03.99 ?), ye? caeaoi? iie?aueoe iiaeeai?, ?aieia?/i?
oa niaeia? aeanoeaino? oa?/iaeo i?iaeoeo?a.

3. ?ic?iaeaii iaoeiaa caaacia/aiiy eiii’thoa?ii? i?ia?aie, yea aea?
ciiao i?iaeooaaoe ?aoeaioo?e i?iaeoeo?a caaeaiiai o?i?/iiai neeaaeo
ca?aeii no/anieo oyaeaiue iaoee i?i oa?/oaaiiy, ei?aeooaaoe o?aaeeoe?ei?
?aoeaioo?e. A ?aaeueieo oiiaao ae?iaieoeoaa oea aeicaieeoue
?aoe?iiaeueii aeei?enoiaoaaoe iayai? ne?iaeii? eiiiiiaioe, a oiio /ene?
ca oiiae ?o aeao?oeeoo.

4. Ca aeiiiiiaith ?ic?iaeaii? i?ia?aie noai?aii ?aoeaioo?e oa?oo oa
iaooaoo, iaeneiaeueii iaaeeaeaieo aei ?aeiiaiaeaoe?e iaoee i?i
oa?/oaaiiy, i?iaaaeaii aeine?aeaeaiiy ?ioaa?aeueii? yeino? ?o c?ace?a.
Anoaiiaeaii, ui aeei?enoaiiy ae??aeaeaeiaeo aeiaaaie ni?ey?
i?aeaeuaiith, ii??aiyii c o?aaeeoe?eieie, nieiaeoino? oa i?aeiino? (ye
iane?aeie iie?auaiiy ?aieia?/ieo oa?aeoa?enoee), oa?/iai? oa a?ieia?/ii?
oe?iiino? eiia?iiaaieo oa?oo oa iaooaoo, ui iieyaa? o ca?eueoaii? ai?noo
iiaiioe?iieo a?ee?a, nooiai? ?o aeei?enoaiiy ia aiaaie?/i? iio?aae
i?aai?cio, i?ia?aeueieo aeaiaio?a, a?oai?i?a ? cieaeaii? e?eueeino?
aee?o, eooiiii? nie?, a oaeiae aia?aaoe/ii? oe?iiino?. Iia? i’yni?
eiina?ae caeaoi? caaeiaieueieoe aeiaiao iio?aao ethaeeie o oaeeo
i?ia?aeueieo ?a/iaeiao, ye eae?e, oinoi?, eaeueoe?e, cae?ci oa o
a?oai?iao — a?oie A, -ea?ioei? ? oieioa?ie?.

5. O ?acoeueoao? aeine?aeaeaiiy nooiaiy aoaeiaaiino? a?ee?a iiaeo
eiia?iiaaieo eiina?a?a i?ioaie?oe/ieie oa?iaioaie a oiiaao in vitro
anoaiiaeaii aeioe?euei?noue ii?aeiaiiy a?ee?a ??ciiai iioiaeaeaiiy aeey
caaacia/aiiy ?o aeniei? ia?ao?aaiino?.

6. Ia iia? aeaee i’ynieo eiina?a?a «Oa?o nineni/iee «Iiaee» oa «Iaooao
«Eaooai» caoaa?aeaeaii ii?iaoeaio aeieoiaioaoe?th (a?aeiia?aeii OO
O01566117.004-97, oaoiieia?/io ?ino?oeoe?th oa OO O01566117.002-97,
oaoiieia?/io ?ino?oeoe?th), cae?eniaii ae?iaieoeoai ia?o?e eiina?a?a o
i?iieneiaeo oiiaao. Aeiiii?/iee aoaeo neeaaea? 300,7 a?. ? 342,5 a?. ia
1 ooao eiia?iiaaieo oa?oo oa iaooaoo a?aeiia?aeii.

7. Ia? i?noea nioe?aeueiee aoaeo, yeee iieyaa? o caaacia/aii? (o oiio
/ene? a aeno?aiaeueieo oiiaao — aeiaaino?ieia? ia?aaiie, aeniaaeeoe??,
a?ae?yaeaeaiiy, oiui) iaaeoiaeaeaiiy aei iianyeaeaiiiai ?aoe?iio
ethaeeie c ?ic?iaeaieie i?iaeoeoaie oe?ieiai niaeo?a iiaeeaieo ?a/iaei o
e?eueeino? oa ni?aa?aeiioaii?, ui ?aeiiaiaeiaai? iaoeith i?i oa?/oaaiiy,
? ye iioaioe?eiee iane?aeie, — cieaeaiiy e?eueeino? iaoieia?e
ae?iaioa?iiai iioiaeaeaiiy.

NIENIE ?IA?O,

ye? aoee iioae?eiaai? ca oaiith aeena?oaoe??.

1. I?eooeuenueea I.A., Caeaitho C.A., Eaca/aiei N.A., Ia?eiaoeiaa ?.A.
I?iaeoeoe oe?eueiaiai i?ecia/aiiy c aeei?enoaiiyi oa?/iaeo aeiaaaie //
Oa?/iaa ? ia?a?iaia i?iieneia?noue, 1993. — ?9. — N.14-15.

2. I?eooeueneay I.A., Eaca/aiei N.A., Aaa?eeeoei A.A. Ea/anoai iiaeo
iyniuo eiina?aia n eniieueciaaieai aaeeiauo eiiiiiaioia // Oacenu
aeieeaaeia iao/ii-i?aeoe/aneie eiioa?aioeee (n iaaeaeoia?iaeiui
o/anoeai) «Iooe ?aoaiey i?iaeaiu ieuaaiai aaeea a Oe?aeia». — E.: EOYE,
1994. — N.143.

3. I?eooeuenueea I.A., Eaca/aiei N.A., Aaa?ee?oei A.A. Iao?aaeeoe?ei?
eiiiiiaioe ne?iaeie oa ?o aeei?enoaiiy o ae?iaieoeoa? eiina?a?a //
Oi?ioaaiiy ani?oeiaioo oa caa??aaiiy oiaa??a o ?eieiaeo oiiaao: Ca.
iaoe. i?aoeue. — E.: EAeOAO, 1995. — N.109-112.

4. I?eooeuenueea I.A., Caeaitho C.A., Eaca/aiei N.A., Iiii/aaia A.?.,
Aaiiiaiei I.I. Iia? i?iaeoeoe ?c caaeaieie aeanoeainoyie ia iniia?
a?eieai?nii? ne?iaeie // Oace aeiiia?aeae anaoe?a?inueei?
ioeiai-oaoi?/ii? eiioa?aioe?? «?ic?iaea oa ai?iaaaeaeaiiy i?ia?aneaieo
oaoiieia?e oa iaeaaeiaiiy o oa?/iao oa ia?a?iaio i?iieneia?noue» (17-20
aeiaoiy 1995?.). — E.: OAeOOO, 1995. — N.254.

5. I?eooeuenueea I.A., Eaca/aiei N.A. Aiae?c ai?iieeneioiiai i?io?eth
iiaeo eiia?iiaaieo i?iaeoeo?a // Oeyoe i?aeaeuaiiy yeino? oa
aaeineiiaeaiiy ani?oeiaioo oiaa??a a oiiaao ia?aoiaeo aei ?eieo: Ca.
iaoe. i?aoeue. — E.: EAeOAO, 1996. — N.11-14.

6. Oaoi?/i? oiiae OO O01566117.004-97 «Eiina?ae i’yni?. Oa?o nineni/iee
«Iiaee». — 11n.

7. Oaoi?/i? oiiae OO O01566117.002-97 «Eiina?ae i’yni?. Iaooao
«Eaooai». — 11n.

8.Oaoiieia?/ia ?ino?oeoe?y ii ae?iaieoeoao eiina?a?a i’ynieo «Oa?o
nineni/iee «Iiaee». — 10c.

9. Oaoiieia?/ia ?ino?oeoe?y ii ae?iaieoeoao eiina?a?a «Iaooao «Eaooai».
— 7c.

10. I?eooeuenueea I.A., Eaca/aiei N.A. Aaeineiiaeaiiy yeino?
eiia?iiaaiiai i’yniiai iaooaoo // «I?eaei?i?ianueeee iaoeiaee a?niee»,
1998. — ? 124 (191). — N.111-115.

11. I?eooeuenueea I.A., Ie?i?e/oe N.O., Aeyaea/ei I.A., Eaca/aiei N.A.,
Aiaiyiei A.E. A?ieia?/ii-aeoeaia eiiiiceoe?y aeey eiia?iiaaieo oa?/iaeo
eiioeaio?ao?a ? eiina?a?a. ??oaiiy i?i aeaea/o iaoaioo a?ae 11.03.99 ca
cayaeith ? 98031088 a?ae 03.03.98.

12. Eaca/aiei N.A. Ioe?iea i?ia?aeueiiai neeaaeo eiia?iiaaieo i’ynieo
eiina?a?a // No/ani? i?iaeaie oiaa?iciaanoaa: Ca. iaoe. i?aoeue. — E.:
EAeOAO, 1999. — N.122-124.

13. Oaoi?/i? oiiae OO O 22845092.008-99 «Iiei/ii-ae??aeaeaeiaa
eiiiiceoe?y». — 14n.

14. Eaca/aiei N.A. I?aeoeea canoinoaaiiy eiii’thoa?iiai iiaeaethaaiiy
aeey noai?aiiy i’ynii?iaeoeo?a ?c caaeaiei ai?noii iiaeeaieo ?a/iaei //
Iaoa??aee i?aeia?iaeii? iaoeiai-i?aeoe/ii? eiioa?aioe?? «Oiaa?iciaanoai
— iaoea, i?aeoeea oa ia?niaeoeae ?icaeoeo a oiiaao ?eieo» (24-25
eenoiiaaea 1999?.). — E.: EAeOAO, 1999. — N.50-55.

Oiiai? iicia/aiiy:

OAE — oa?/iaee a?eeiaee eiioeaio?ao;

AAE — a?oai?i?ciaaiee a?eeiaee eiioeaio?ao;

AeA — ae??aeaeaeia? aeno?aeoe;

AEOC — aee?ioo?eioth/a caeaoi?noue;

AOC — aiaeioo?eioth/a caeaoi?noue;

NIA — nooi?iue iaaooaiiy o aiae?;

NIAE — nooi?iue iaaooaiiy o aee??;

?OA — ?ic/eii?noue o aiae?.

Eaca/aiei N.A. Oiaa?iciaa/a oa?aeoa?enoeea eiia?iiaaieo i’ynieo
eiina?a?a, i?ecia/aieo aeey ?aoe?iiaeueiiai oa?/oaaiiy. — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa oaoi?/ieo iaoe
ca niaoe?aeuei?noth 05.18.15 — oiaa?iciaanoai oa?/iaeo i?iaeoeo?a. —
Ee?anueeee aea?aeaaiee oi?aiaaeueii-aeiiii?/iee oi?aa?neoao,
I?i?noa?noai ina?oe Oe?a?ie, Ee?a, 1999 ?.

Aeena?oaoe?th i?enay/aii ?ic?iaoe? oa oiaa?iciaa/?e ioe?ioe? iiaeo
eiia?iiaaieo i’ynieo eiina?a?a c aeei?enoaiiyi ae??aeaeaeiaeo aeiaaaie.
I?iaeooaaiiy ?aoe?iiaeueieo ?aoeaioo? i?iaeoeo?a cae?eniaii ca
aeiiiiiaith eiii’thoa?ii? i?ia?aie ca aecia/aieie e?eoa??yie
iioei?caoe??, ui a?aeiia?aeathoue no/aniei oyaeaiiyi iaoee i?i
oa?/oaaiiy. Aia?oa aeey aaeainoaaiiy ai?iieeneioiiai oa i?ia?aeueiiai
i?io?eth eiia?iiaaieo eiina?a?a aeei?enoai? ae??aeaeaeia? aeiaaaee oa
io?eiai? ia ?o iniia? iiei/ii-ae??aeaeaeiaa ? a?ieia?/ii-aeoeaia
eiiiiceoe??, aeey /iai i?iaaaeai? eiiieaeni? aeine?aeaeaiiy ?oiuei?
yeino?.

Aiane?aeie oiaa?iciaa/i? ioe?iee iiaeo eiia?iiaaieo i’ynieo eiina?a?a
aeiaaaeaii aoaeoeai?noue canoinoaaiiy aiae?oe/iiai iiaeaethaaiiy aeey
io?eiaiiy i?iaeoeo?a aeniei? oa?/iai? oa a?ieia?/ii? oe?iiino?, iieacaii
aieea ae??aeaeaeiaeo aeiaaaie ia ooieoe?iiaeuei? aeanoeaino?
eiia?iiaaieo oa?oo oa iaooaoo. I?aeoaa?aeaeaiiyi aeniei? a?ieia?/ii?
oe?iiino? eiina?a?a ? i?iaaaeai? aeine?aee a oiiaao in vitro. Aea/aii
caeiiii??iino? ci?i iniiaieo oa?aeoa?enoee eiia?iiaaieo oa?oo oa iaooaoo
a i?ioean? caa??aaiiy.

Eeth/ia? neiaa: eiia?iiaai? i’yni? eiina?ae, ae??aeaeaeia? aeiaaaee,
iiei/ii-ae??aeaeaeiaa ? a?ieia?/ii-aeoeaia eiiiiceoe??, eiii’thoa?ia
i?ia?aia, aiae?oe/ia iiaeaethaaiiy, oiaa?iciaa/a ioe?iea.

Eaca/aiei N.A. Oiaa?iaaaeiay oa?aeoa?enoeea eiiaeie?iaaiiuo iyniuo
eiina?aia, i?aaeiacia/aiiuo aeey ?aoeeiiaeueiiai ieoaiey. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa oaoie/aneeo iaoe
ii niaoeeaeueiinoe 05.18.15 — oiaa?iaaaeaiea ieuaauo i?iaeoeoia. —
Eeaaneee ainoaea?noaaiiue oi?aiai-yeiiiie/aneee oieaa?neoao,
Ieienoa?noai ia?aciaaiey Oe?aeiu, Eeaa, 1999 a.

Aeenna?oaoeey iinayuaia ?ac?aaioea e oiaa?iaaaeiie ioeaiea iiauo
eiiaeie?iaaiiuo iyniuo eiina?aia n eniieueciaaieai ae?iaeaeaauo
aeiaaaie. I?iaeoe?iaaiea ?aoeeiiaeueiuo ?aoeaioo? i?iaeoeoia
inouanoaeaii n iiiiuueth eiiiuethoa?iie i?ia?aiiu a niioaaonoaee n
ii?aaeaeaiiuie e?eoa?eyie iioeiecaoeee, eioi?ua ioaa/atho nia?aiaiiui
i?aaenoaaeaieyi iaoee i ieoaiee.

Aia?aua aeey aaeaine?iaee aieiieeneioiiai, ieia?aeueiiai i?ioeey
eiiaeie?iaaiiuo eiina?aia eniieueciaaiu ae?iaeaeaaua aeiaaaee e
iieo/aiiua ia eo iniiaa iiei/ii-ae?iaeaeaaay e aeieiae/anee-aeoeaiay
eiiiiceoeee, aeey /aai i?iaaaeaiu eiiieaeniua enneaaeiaaiey eo ea/anoaa.
Onoaiiaeaii, /oi ae?iaeaeaaua aeiaaaee oa?aeoa?ecothony neaaeothueie
iieacaoaeyie, eioi?ua iicaieytho yooaeoeaii i?eiaiyoue eo a ieuaaie
i?iiuoeaiiinoe: iaeo?aeueiuie i?aaiieaioe/aneeie naienoaaie; aenieei
niaea?aeaieai aaeea e ieceei — aee?a; ?aciiia?aciui aieiieeneioiui
ninoaaii n aunieei niaea?aeaieai iacaiaieiuo aieiieeneio; oe?ieei
niaeo?ii ieia?aeueiuo aauanoa; aieueoei eiee/anoaii aeoaieiia a?oie A e
ieaoeeia; aunieeie ooieoeeiiaeueiuie naienoaaie. E?iia oiai,
ae?iaeaeaaua aeiaaaee yaeythony aaca?aaeiuie e eaaeionaiyaiuie. Eo
eniieueciaaiea i?e i?iecaiaenoaa iyniuo i?iaeoeoia ia o?aaoao ?anoiaeia
ia i?eia?aoaiea aeiiieieoaeueiiai iai?oaeiaaiey.

A ?acoeueoaoa oiaa?iaaaeiie ioeaiee iiauo eiiaeie?iaaiiuo iyniuo
eiina?aia aeieacaia yooaeoeaiinoue i?eiaiaiey aiaeeoe/aneiai
iiaeaee?iaaiey aeey iieo/aiey i?iaeoeoia aunieie ieuaaie e aeieiae/aneie
oeaiiinoe. Aeia?eiaioaeueiuie enneaaeiaaieyie onoaiiaeaii, /oi
eniieueciaaiea ae?iaeaeaauo aeiaaaie a ninoaaa iynieo oa?oa e iaooaoa
niinianoaoao iiauoaieth, ii n?aaiaieth n o?aaeeoeeiiiuie, niaea?aeaiey
iieiioeaiiuo aaeeia (ia 17,0% e 13,8% niioaaonoaaiii), ieia?aeueiuo
yeaiaioia (ia 4,0% e 13,3%), aeoaieiia e nieaeaieth eiee/anoaa aee?a (ia
24,5% e 62,8%), iiaa?aiie niee (ia 46,6% e 23,0%), a oaeaea
yia?aaoe/aneie oeaiiinoe (ia 14,6% e 41,7% niioaaonoaaiii). Iiaua iyniua
eiina?au niiniaiu oaeiaeaoai?eoue nooi/ioth iio?aaiinoue /aeiaaea a
oaeeo ieia?aeueiuo aauanoaao, eae eaeee, oinoi?, eaeueoeee, aeaeaci e a
aeoaieiao — a?oiiu A, -ea?ioeia e oieioa?iea. Aeaiiua eco/aiey
no?oeoo?ii-iaoaie/aneeo e aeae?aoaoeeiiiuo oa?aeoa?enoee iieacuaatho,
/oi eiiaeie?iaaiiua iyniua eiina?au iaeaaeatho aunieeie oaoiieiae/aneeie
naienoaaie, a /enea eioi?uo ieanoe/iinoue e aeaainaycuaathuay
niiniaiinoue.

Aunieay aeieiae/aneay oeaiiinoue aaeeia eiiaeie?iaaiiuo iyniuo
eiina?aia ii?aaeaeyaony eaaeie aoaeoaiinoueth i?ioaieeoe/aneeie
oa?iaioaie, oi?ioae onaiyaiinoueth, /oi iiaeoaa?aeaeatho aeaiiua iiuoia
a oneiaeyo in vitro.

?acoeueoaou enneaaeiaaiey aeeiaieee ea/anoaaiiuo iieacaoaeae
eiiaeie?iaaiiuo iyniuo eiina?aia a i?ioeanna o?aiaiey i?e oaiia?aoo?a
182N e ioiineoaeueiie aeaaeiinoe ia aieaa 75% naeaeaoaeuenoaotho i
nio?aiaiee i?aaiieaioe/aneeo iieacaoaeae ia ia/aeueiii o?iaia,
ionoonoaee aoeueeiiuo ioaeaeaiee, aee?iauo ioaeia. I?iaaaeaiu
iee?iaeieiae/aneea enneaaeiaaiey eiiaeie?iaaiiuo eiina?aia, eioi?ua
iieacaee iieiia ionoonoaea a ieo iaoiaaiiie iee?ioei?u.

Ii ?acoeueoaoai enneaaeiaaiee iioaeeeiaaii 6 noaoae. Ia eiiaeie?iaaiiua
iyniua eiina?au «Oa?o nineni/iue «Iiaue» e «Iaooao «Eaooai» ?ac?aaioaia
e ooaa?aeaeaia ii?iaoeaiay aeieoiaioaoeey. Inouanoaeaii i?iiuoeaiiia
aiaae?aiea iiauo iyniuo eiina?aia ia CAO «Eeaaneee iynieiiaeiao».

Eeth/aaua neiaa: eiiaeie?iaaiiua iyniua eiina?au, ae?iaeaeaaua aeiaaaee,
iiei/ii-ae?iaeaeaaay e aeieiae/anee-aeoeaiay eiiiiceoeee, eiiiuethoa?iay
i?ia?aiia, aiaeeoe/aneia iiaeaee?iaaiea, oiaa?iaaaeiay ioeaiea.

Eazachenki S.V. The Nimmidity Characteristic of Combined Meat Tins for
Rational Feading. — Manuscript.

The candidate of engineering science degree thesis on a speciality
05.18.15 — Science of Food Stuffs. — Kyiv State University of Trade and
Economics, Ministry of Education of Ukraine, Kyiv, 1999.

This thesis is devoted to the working out and cimmidity evaluation of
new combined meat tins with yeast additives. The modelling of rational
recipes of food is made with the help of computer programs in accordance
with the defined criterions of optimization which suit the modern
submissions of science of feeding. For the first time the yeast
additives were used for aminoacid and minerals profile balancing, the
milk-yeast and bio-active compositions were obtained on this basis, and
complex researche of their quality was carried out.

After cimmidity evaluation of new combined meat tins the efficiency of
applying of analytical modelling for making of high nutritional and
biological value food stuffs was proved, the influence of yeast
additives on the functional properties of forcemeat and pate was shown.
The research in vitro conditions is the improvement of high biological
value. The regularities of the main characteristics changes of forcemeat
and pate during storage were studied.

Key words: combined meat tins, yeast additives, milk-yeast and
bio-active compositions, computer the program, analytical modelling,
cimmidity evaluation.

EACA*AIEI Na?oeaia Aieiaeeie??aia

OIAA?ICIAA*A OA?AEOA?ENOEEA EIIA?IIAAIEO I’ssNIEO EIINA?A?A, I?ECIA*AIEO
AeEss ?AOe?IIAEUeIIAI OA?*OAAIIss

I?aei.aei ae?oeo 24.12.99. Oi?iao 6084/16. Iai?? ienuei.

Ion.ae?oe. Oi.ae?oe.a?e. 0,99. Oi.oa?ai-a?aea. 1,02

Iae.-aeae. a?e. 1,00. Oe?aae 100 i?. Cai.696.

Aeaeaaie/ee oeaio? EAeOAO. Ae?oea?iy AOe EAeOAO.

02156, Ee?a-156, aoe. E?ioi, 19

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