I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO AI?AeAI?IEIA?? OA ?IOAEOe?EIEO
OAI?IA

?i. E.A. A?IIAOAANUeEIAI

Eyoie Ieueaa Aanee?aia

OAeE 616.32-002-08 : 578.245

OA?AIAAOE*IA AOAEOEAI?NOUe EAOA?IIO

A EIIIEAENIIIO E?EOAAII? OAI?EO

IA AINO?EE A??ONIEE AAIAOEO A

14.01.13 – ?ioaeoe?ei? oai?iae

AAOI?AOA?AO

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a-1999Aeena?oaoe?y ? ?oeiien.

?iaioa aeeiiaia a Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai

Iaoeiaee ea??aiee – aeieoi? iaaee/ieo iaoe Aeea Aeieo??aia AIAE,

Ee?anueeee IAe? ai?aeai?ieia?? oa

?ioaeoe?eieo oai?ia, caa?aeoaa/ ee?i?ee

a??oniiai aaiaoeoo c aeieii NI?Aeo

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Aeieo?i Oaaei?iae/ EE?E*AIEI, A?iieoeueeee

aea?aeaaiee iaaee/iee oi?aa?neoao, ?i. I.?.
Ie?iaiaa,

caa?aeoaa/ eaoaae?e ?ioaeoe?eieo oai?ia;

aeieoi? iaaee/ieo iaoe, i?ioani?

?aaai Aaneeueiae/ I?E?O?I, Iaeanueeee
aea?aeaaiee

iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?e ?ioaeoe?eieo oai?ia

I?ia?aeia onoaiiaa – Oa?e?anueeee aea?aeaaiee iaaee/iee

oi?aa?neoao IIC Oe?a?ie, Oa?e?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny: 27 n?/iy 2000 ?ieo i 12 aiae. ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.614.01 i?e Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i E.A. A?iiaoaanueeiai (252015, i. Ee?a-15, aoe. N?/iaaiai iianoaiiy,
23. Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa
?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i.
E.A. A?iiaoaanueeiai.

Aaoi?aoa?ao ?ic?neaiee 25 a?oaeiy 1999 ?.

Aeeiioth/ee iaia’ycee a/aiiai nae?aoa?y

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe A.I. ?oaeaiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Inoaii? aeanyoe??//y a?aecia/a?oueny
i?ia?anoth/ei ?ioa?anii aei i?iaeaie a??onieo aaiaoeo?a, cia/ieie
aeinyaiaiiyie a ?? aea/aii?. A??oni? aaiaoeoe (AA) ? aaaeeith
aeiaaeueiith i?iaeaiith, ana ua aeaeaeith a?ae naiai ae??oaiiy.

Iaea?eueoo oaaao i?eaa?oathoue a??oni? aaiaoeoe c ia?aioa?aeueiei oeyoii
ia?aaea/?, ye? iathoue aenieee o?ii?/iee iioaioe?ae. Naia oiio HBV-,
HCV-, HDV-?ioaeoe?? a iniiaiiio oi?iothoue anth a?oio o?ii?/ieo
caoai?thaaiue ia/?iee – o?ii?/i? aaiaoeoe, oee?ic ia/?iee,
aaiaoioeaethey?io ea?oeeiiio (Oa?thiia A.E., 1988; Aiae?ae/ei I.A.,
1990, 1999; Aic?aiiaa AE.?., 1997; Alter M.J., Mast E.E., 1996).

Ca aeaieie AIIC a ??cieo e?a?iao na?oo a??onieie aaiaoeoaie ?io?eiaaii
a?eueoa iaeiiai ie?ae. ianaeaiiy, ui cia/ii ia?aaeuo? ?iciianthaeaeaiiy
A?E-?ioaeoe?? oa a?eueoa o?aoeie ianaeaiiy na?oo aaea aoei ?io?eiaaii ?
ca?ac 5% c ieo (350 iei. /ieia?e) ? iin?yie oe??? ?ioaeoe??. Eiaeiiai
?ieo a na?o? a?ae iaoieia?e, iia’ycaieo c oe??th oai?iaith, iiie?a? a?ey
2 iei. /ieia?e (Van Damme, 1995).

Ia a?aei?io a?ae aaaaoueio ?ioaeoe?e, ui ia?aa?aathoue oeeee?/ii, AA
ia??aeei iaaoaa? o?ii?/iiai ia?aa?ao. O 5-10 % aino?ee aaiaoeo A
o?ainoi?io?oueny a o?ii?/iee.

Oa?eoi??y Oe?a?ie iaeaaeeoue aei ?aa?ii?a c aenieei ??aiai
?iciianthaeaeaiiy AA. Oae, o 1992 ?. caaaeueia caoai?thaai?noue ia AA
neeaaeaea 23,10, o 1993 ?. – 24,82, a 1994 ?. – 24,88, o 1995 ?. –
25,21, o 1996 ?. – 23,40, o 1997 ?. – 19,67, o 1998 ?. – 17,80 ia 100
oen. ianaeaiiy. ?aaeueia e?euee?noue caoai?thaaiue ia AA a Oe?a?i? o 5-6
?ac?a ia?aaeuo? aeai? io?oe?eii? noaoenoeee. *anoioa aeyaeaiiy iin??a
HBsAg na?aae ??cieo a?oi aei?ineiai ianaeaiiy a na?aaeiueiio noaiiaeoue
2,2 %, a na?aae aeiii??a – 1,2 % (Ao?aeue A.E. c ni?aaao., 1999).

O?ii?/ia oi?ia a??oniiai aaiaoeoo A ioe?ith?oueny aaaaoueia aaoi?aie ye
iae?iciianthaeaeai?oa o?ii?/ia a??onia ?ioaeoe?y a na?o? (Oa?thiia A.E.,
A?iiaoaanueea E.E. c ni?aaao., 1994; Aiae A.Ae., Oaoueyiei I.A., 1999;
Ni?einii N.I., 1997; Sherlock S., Doodly, 1997).

Na?aae iaea?eueo neeaaeieo ? aei e?ioey ia ae??oaieo ieoaiue oe???
aaaaoia?aiii? i?iaeaie ? e?eoaaiiy oai?eo ia AA.

Ee?i?/iee aeina?ae iieaco?, ui aeei?enoaiiy caaaeueiii?eeiyoiai
e?eoaaiiy ia caaaeaee caaacia/o? iaae?eiee oa?aiaaoe/iee aoaeo.
A?eueo?noue iaaeeeaiaio?a, ye? aeei?enoiaoaaeeny ?ai?oa, nueiaiaei?
i?aaenoaaeythoue eeoa ?noi?e/iee ?ioa?an, ?io? – nei??oa o?aaeeoe?ei?.

C iaoith i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia a??oni? aaiaoeoe
noai?ththoueny ??ci? i?aia?aoe, ui iiaeooue aooe aeei?enoai? ye caniae
ao?io?iiii? oa iaoiaaiaoe/ii? oa?ai??.

Iaeiei c iaecia/i?oeo aeinyaiaiue no/anii? aaiaoieia?? ne?ae aaaaeaoe
i?ioea??onio oa?ai?th (Aiae?ae/ei I.A., 1996; Eiacei TH.A., AEaeaiia
E.A., 1997; Aaaao A.A., 1998).

A inoaii? ?iee c’yaeeiny aaaaoi ioae?eaoe?e a?o/eciyieo oa ?iicaiieo
aaoi??a i?i canoinoaaiiy a eiiieaeni?e oa?ai?? a??oniiai aaiaoeoo A
i?aia?ao?a ?OI, ye? iathoue oae? aaaeeea? aeanoeaino?, ye i?ioea??onia
oa ?ioiiiiaeoethth/a. Oe? aeanoeaino? ? i?aenoaaith aeey aeei?enoaiiy
eiai a eiiieaeni?e oa?ai?? AA ye ao?iiaoiaaiaoe/iiai caniao.

Iacaaaeath/e ia aaeeeo e?euee?noue ioae?eaoe?e, i?enay/aieo
?ioa?oa?iiioa?ai??, iaeiicia/ii? aeoiee uiaei canoinoaaiiy i?ioea??onieo
i?aia?ao?a iaia?, ea?aeeiaeuei? ieoaiiy oe??? i?iaeaie iio?aaothoue ua
iiaeaeueoiai aea/aiiy. Ia c’yniaai? iieacaiiy aeey i?ecia/aiiy, no?iee,
aeice oa o?eaae?noue ?OI-oa?ai??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa aeeiiaia a ieai? caaaeueii? i?ia?aie aeine?aeaeaiue ii i?iaeai?
“A??oni? aaiaoeoe”, ? /anoeiith ieaiiaeo iaoeiai-aeine?aeieo ?ia?o, ye?
aeeiioaaeenue o Ee?anueeiio IAe? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i. E.A. A?iiaoaanueeiai IIC Oe?a?ie.

Iaoa ? caaaeaiiy aeine?aeaeaiiy

I?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia AA oa iiia?aaeaeaiiy
iani?eyoeeaeo iane?aee?a c o?aooaaiiyi ee?i?/ieo, a?io?i?/ieo,
na?ieia?/ieo aeaieo oa iieaciee?a ?ioa?oa?iiiaaiaco.

Ca?aeii c iaoith ae??ooaaeeny ianooii? caaea/?:

1. Aecia/eoe ee?i?/io aoaeoeai?noue eaoa?iio o oai?eo ia AA ?c a?oi
?eceeo o?ii?caoe?? a caeaaeiino? a?ae oi?ie aaaeeino?, ia?aa?ao oai?iae,
aeice oa o?eaaeino? i?ecia/aiiy i?aia?aoo.

2. Aea/eoe a?io?i?/i? iieacieee, ui oa?aeoa?ecothoue neiae?ii oeeoie?co
(aeoeai?noue AeAO a oe?euei?e oa ?icaaaeai?e ne?iaaoeao e?ia?),
ii?ooaiiy iai?io aeia/ieo i?aiaio?a (iieacieee caaaeueiiai oa i?yiiai
a?e??oa?io), a oaeiae o?eaae?noue HBs-aioeaaiai?? oa ?ioeo ia?ea??a AA o
oai?eo, yeei i?ecia/aany eaoa?ii.

3. Aeine?aeeoe a aeeiai?oe? iieacieee ee?oeiiiai ?ioi?oaoo oa noai
?ioa?oa?iiiaaiaco o oai?eo ia AA, ye? io?eioaaee eaoa?ii.

4. Aea/eoe aeecuee? oa a?aeaeaeai? iane?aeee aaiaoeoo A o oai?eo, yeei
i?ecia/aany eaoa?ii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. A ?iaio? iaoeiai iaa?oioiaaia
aeioe?euei?noue aeei?enoaiiy eaoa?iio c iaoith iiia?aaeaeaiiy
iani?eyoeeaeo iane?aee?a AA.

Aea/aia oa?aiaaoe/ia aoaeoeai?noue a?o/eciyiiai aaiii?iaeaia?iiai
aeueoa-2b-?ioa?oa?iio i?e ??cieo oi?iao aaaeeino? AA o oai?eo c a?oi
?eceeo o?ii?caoe??, aea/ai? noaie eiai canoinoaaiiy.

Aeine?aeaeaiee aieea eaoa?iio ia iieacieee ?ioa?oa?iiiaaiaco o oai?eo ia
AA.

Io?eiai? iia? aeai? uiaei iane?aee?a AA o oai?eo, ye? io?eioaaee
eaoa?ii.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. A ?iaio? iieacaii, ui
canoinoaaiiy eaoa?iio a eiiieaeniiio e?eoaaii? oai?eo ia AA c a?oi
?eceeo o?ii?caoe?? i?eaiaeeoue aei a?eueo oaeaeei? ?aa?an?? ee?i?/ieo
neiioii?a, i?enei?th? a?aeiiaeaiiy ii?ooaieo a i?ioean? caoai?thaaiiy
ooieoe?e ia/?iee, ui i?iyaey?oueny o cieaeaii? a?io?i?/ieo iieaciee?a
(aeoeaiino? AeAO, caaaeueiiai oa i?yiiai a?e??oa?io), o?eaaeino?
HBs-aioeaaiai??; iiceoeaii aieeaa? ia noai ?ioiii? nenoaie oa noeioeth?
?ioa?oa?iiiaaiac, ciaioo? e?euee?noue caoyaeieo oi?i AA, caiia?aa?
o?ainoi?iaoe?? aino?iai AA o o?ii?/iee.

?ic?iaeai? ee?i?/i? iieacieee oa noaie e?eoaaiiy ia?oei a?o/eciyiei
i?aia?aoii – eaoa?iiii – oai?eo ia aino?ee AA c a?oi ?eceeo o?ii?caoe??
iaoieia?/iiai i?ioeano.

Iniaenoee aianie caeiaoaa/a. An? aoaie aeine?aeaeaiiy aeena?oaio
cae?enieea naiino?eii. Aaoi?ii ia?niiaeueii i?iaiae?ciaaia iaoeiaa
e?oa?aoo?a c i?iaeaie, yea aeine?aeaeoaaeany, i?iaaaeaiee ?ioi?iaoe?eiee
iiooe, naiino?eii aeeiiaia ee?i?/ia ianoaaeaiiy oai?eo, i?iaaaeaia
noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiiy, iaienai? an? ?icae?ee
?iaioe, noi?ioeueiaai? aeniiaee oa i?aeoe/i? ?aeiiaiaeaoe??.

Iniiai? iieiaeaiiy aeena?oaoe?eii? ?iaioe aeei?enoiaothoueny a
i?aeoe/i?e ?iaio? i?e e?eoaaii? oai?eo ia AA.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iaoa??aee aeena?oaoe?eii? ?iaioe iaaiai?thaaeenue ia iaoeiaeo
eiioa?aioe?yo ee?i?/iiai a?aeae?eo EIAe?A?O, aeiiia?aeaeenue ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo a ii. Ee?a? (1993 ?.), Oiaeueieoeueeiio
(1993, 1996 ??.), Iieoaa? (1994 ?.), ??aiiio (1995 ?.), Eueaia? (1995
?.), sseo? (1996 ?.), Noiao (1997 ?.), ia IV Oe?a?inueeiio C’?cae?
?ioaeoe?ii?no?a Oe?a?ie (Oa?iii?eue, 1998).

Io?eiai? ?acoeueoaoe ?iaioe aeeth/ai? aei “Iaoiaee/ieo iniia ee?i?/iiai
canoinoaaiiy eaoa?iio (?aeiia?iaioiiai a-2b ?OI) “(OON-42 V-82-112-95),
??aia 1996 ?. Ai?iaaoe?y aeena?oaoe?? a?aeaoeany 27.10.99 ?. ia
can?aeaii? ai?iaaoe?eii? ?aaee ee?i?/iiai a?aeae?eo EIAe?A?O.

Ca oaiith aeena?oaoe?? iioae?eiaaii 13 iaoeiaeo ?ia?o, c yeeo 5 o
aeaeaiiyo, ye? aecia/ai? AAEii Oe?a?ie o yeino? oaeeo, aea iiaeooue aooe
iioae?eiaai? iaoa??aee eaiaeeaeaonueeeo oa aeieoi?nueeeo aeena?oaoe?e,
oa 2 ?ioi?iaoe?eieo eenoa.

No?oeoo?a ? ianya aeena?oaoe??. ?iaioa aeeeaaeaia ia 156 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e,
?icae?eo caaaeueiiee?i?/ieo oa niaoe?aeueieo iaoiae?a aeine?aeaeaiiy
oai?eo, 5 ?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a,
nieneo aeei?enoaii? e?oa?aoo?e, yeee aeeth/a? 269 aeaea?ae. Aeena?oaoe?y
i?noeoue 23 oaaeeoeue, 15 ?enoie?a, 3 aeoya?a ?c ?noi??e oai?ia.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

?iaioa aeeiioaaeany o Ee?anueeiio IAe? ai?aeai?ieia?? oa ?ioaeoe?eieo
oai?ia ?iai? E.A. A?iiaoaanueeiai. Aeey aeeiiaiiy iinoaaeaieo caaea/
ianoaaeaii 217 oai?eo ia AA a?eii a?ae 15 aei 62 ?ie?a – 106 /ieia?e?a
(48,1 %) oa 111 ae?iie (51,9 %). 137 oai?eo io?eioaaee eaoa?ii a
eiiieaeniiio e?eoaaii? (iniiaia a?oia), c ieo 69 /ieia?e io?eioaaee
eaoa?ii ii 2 iei. IAe aioo??oiueii’yciai i?ioyaii 14-20 aei?a (I a?oia),
68 in?a – ii 3 iei. IAe /a?ac aeaiue i?ioyaii 15-21 aeiy (II a?oia). 80
oai?eo io?eioaaee caaeueiii?eeiyoo aacenio oa?ai?th (eiio?ieueia a?oia).

An? ianoaaeai? oai?? iaee noiooith iaoieia?th. Ca iayai?noth noiooiuei?
iaoieia?? a?oie oai?eo, ye? aeine?aeaeoaaeeny, aoee iaeii??aeieie.

Eaoa?ii, yeee aeei?enoiaoaaany aeey e?eoaaiiy oai?eo ia AA – ia?oee
a?o/eciyiee ?aeiia?iaioiee a-2b ?ioa?oa?ii, oaoiieia?y neioaco yeiai
?ic?iaeaia a ?inoeooo? iieaeoey?ii? a?ieia?? oa aaiaoeee IAI Oe?a?ie.
Oeae i?aia?ao neioaciaaiee ee?oeiaie E. coli ia iniia? aaio, yeee eiaeo?
i?iaeoeo, ?aeaioe/iee a-2 ?ioa?oa?iio ethaeeie, c aeei?enoaiiyi
oaaicaeaaeii? aaiii-?iaeaia?ii? a?ioaoiieia??.

Aiae?c aoaeoeaiino? eaoa?iio a eiiieaeniiio e?eoaaii? oai?eo ia AA
i?iaaaeaiee ia i?aenoaa? ee?i?/ieo, a?io?i?/ieo, na?ieia?/ieo,
?ioiieia?/ieo iieaciee?a oa noaio ?ioa?oa?iiiaaiaco.

Niinoa?aaeaiiy ca oai?eie i?iaiaeeeenue o a?aeae?eaii? a??onieo
aaiaoeo?a, a i?ney aeienee c noaoe?iia?o /a?ac 1, 3, 6 oa 12 i?nyoe?a a
aeeniaina?ii-iie?ee?i?/iiio a?aeae?eaii? EIAe?A?O.

O an?o oai?eo ae?aaiic AA aoa aa??o?eiaaiee aeae?eaiiyi HBsAg iaoiaeaie
?IAA oa ?OA ia oano-nenoaiao IAe?AI i. Ieaei?e Iiaai?iae; o 54 oai?eo
oaeiae iayai?noth HBeAg, aioe-HBe oa aioe-HBcIg I oa G; o 50 oai?eo –
HBV-AeIE ia oano-nenoaiao o??ie Abbott (USA) oa Sanofi Diagnostic
Pasteur (O?aioe?y).

Oi?ia aaaeeino? oai?iae aecia/aeeny, aeoiaey/e c ioe?iee nooiaiy
caaaeueii? ?ioieneeaoe??, ?ioaineaiino? aeiaoyieoe?, ??aiy
a?ia?oa?iaioai??, ca?eueoaiiy ?ici???a ia/?iee.

Eiioeaio?aoe?y a?e??oa?io oa eiai o?aeoe?e a ne?iaaooe? aecia/aee
iaoiaeii L. Gendrasiek,P. Grof, 1938; aeoeai?noue aeai?iai?iio?ainoa?ace
(AeAO) a oe?euei?e oa ?icaaaeai?e ne?iaaooe? (1:10 o?c?ieia?/iei
?ic/eiii) iaoiaeii S. Reitman, F. Frankel, 1967 o iiaeeo?eaoe?? E.E.
A?iiaoaanueei?, 1970; oeiieiao i?iao, oieanoa?ei, a?eeia? o?aeoe??,
i?io?iia?iiaee ?iaeaen aeeiioaaee oi?o?eiaaieie iaoiaeaie. A?io?i?/i?
iieacieee ae?aaeaeeny o I?aeia?iaei?e nenoai? iaeeieoeue N? (1978 ?.).

Noai ee?i?/iiai ?ioi?oaoo aecia/aee ca aeiiiiiaith iaoiaeo eiia?iiaaiiai
?icaoeiooai?aiiy (N. Mendes, 1974; S. Limatibul, 1976).

Aeoeai?noue ?OI a ne?iaaooe? e?ia? aeine?aeaeoaaee caaaeueiii?eeiyoei
i?ia??i/iei iaoiaeii ii i?eai?/aiith oeeoiiaoe/ii? ae?? a??ono
aaceeoey?iiai noiiaoeoo (ooai ?iae?aia) a eoeueoo?? ethaenueeeo ee?oei
E-41. Aeey aecia/aiiy ?ioa?oa?iiiai? ?aaeoe?? eaeeioeeo?a (??E)
aeei?enoiaoaaee iaoiae Nieiaeiaa A.Ae., Aaeoaie?iaa O.A., 1979 ?.

Noaoenoe/ia ia?iaea io?eiaieo ?acoeueoao?a cae?enithaaeany ca
aeiiiiiaith iaeaoo noaoenoe/ii? ia?iaee ?ioi?iaoe?? “Statpac” o??ie
“Microsoft” ia ?AI-noi?niiio eiii’thoa??.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

I?e aeine?aeaeaii? ai?aeai?ieia?/iiai aiaiiaco anoaiiaeaii, ui i?ioyaii
inoaii?o 2-12 i?nyoe?a aei caoai?thaaiiy, 40 iaoe??io?a (18,4%)
io?eioaaee aioo??oiueiaaii? aai aioo??oiueii’ycia? ?i’?eoe??; 25 (11,5%)
– e?eoaaeeny o a?iaeieiaa; 24 (11,1%) – o noiiaoieiaa; 62 (28,6%) –
aaeeaaee ia?aioa?aeueii ia?eioeee; 3 (1,4%) – caeaaaee e?ia ye aeiii?e;
20 (9,2%)– caoai??ee i?ney i?iaaaeaiiy iia?aoe?eieo ao?o/aiue aai
ae?aaiinoe/ieo iai?ioeyoe?e; 18 (8,3%) – ?io?eoaaeeny noaoaaei oeyoii;
22 (10,1 %) neeaee iaaei?aoe?aieee, ye? iaee eiioaeo c e?ia’th oai?eo; o
3 oai?eo (1,4%) oeyo ca?aaeaiiy anoaiiaeoe ia aaeaeiny.

Ii/aoie caoai?thaaiiy aoa iia?eueiei o 112 oai?eo (51,6%), aino?ei o 105
(48,4%). O ia?aaeaeiaoyie/iiio ia??iae? /ano?oa anueiai niinoa??aaeeny
caaaeueii?ioaeoe?eiee (91,2%), a?o?aea?/iee (23,5%), aeeniaioe/iee
(25,3%) neiae?iie. Aiae?coth/e io?eiai? aeai?, iiaeia a?aecia/eoe, ui o
an?o oai?eo aoea ca?eueoaia ia/?iea, o 30,6 % oai?eo c
na?aaeiueiaaaeeith oi?iith AA oa o 34,9% in?a c aaaeeith oi?iith AA aoea
ca?eueoaia naeac?iea ? a ee?i?/i?e ea?oei? ia?aaaaeaee
caaeueii?ioaeoe?eiee, a?o?aea?/iee, aeeniaioe/iee neiae?iie a ia??iae?
?iciaeo aeiaoyieoe? ye i?e aaaee?e, oae ? i?e na?aaeiueiaaaee?e oi?i?
AA.

Aeine?aeaeaiiy iieacaee, ui e?eoaaiiy eaoa?iiii oai?eo ia AA ye c
na?aaeiueiaaaeeith, oae ?c aaaeeith oi?iith AA i?eaiaeeoue aei
nei?i/aiiy o?eaaeino? an?o ee?i?/ieo neiioii?a, ii??aiyii c iieacieeaie
eiio?ieueii? a?oie. I?e oeueiio aeyaeai? a?eueo ae?aaeai? iiceoeai?
ci?ie ee?i?/iiai ia?aa?ao i?e aeei?enoaii? i?aia?aoo ii 2 iei. IAe a/i
eiaeiiai aeiy, i?ae ii 3 iei. IAe /a?ac aeaiue.

Ee?i?/io ioe?ieo e?eoaaiiy oai?eo ia AA, cie?aia eaoa?iiii,
aeiiiaiththoue a?io?i?/i? iieacieee. Aiae?coth/? io?eiai? aeai?,
aeyaeaii, o oai?eo ia AA c aaaeeith oi?iith ia 14-20 aeaiue ai?no
caaaeueiiai a?e??oa?io ciaioeany ia 59% o oai?eo, ye? io?eioaaee eaoa?ii
ii 2 iei. IAe a/i uiaeaiii, ia 71% o oai?eo, ye? e?eoaaeeny eaoa?iiii ii
3 iei. IAe a/i /a?ac aeaiue ? eeoa ia 35% o oai?eo eiio?ieueii? a?oie;
ai?no i?yiiai a?e??oa?io ciaioeany ia 59, 74 oa 31 %; aeoeai?noue AeAO a
oe?euei?e ne?iaaooe? – ia 63%, 54%, 35% a?aeiia?aeii, ii??aithth/e c
??aiai ia iiiaio aini?oae?caoe??.

O oai?eo c na?aaeiueiaaaeeith oi?iith AA, yeei i?ecia/aee eaoa?ii,
iieacieee niaaeo ai?noo caaaeueiiai oa i?yiiai a?e??oa?io aeinoia??ii
a?ae??ciyeeny a?ae iieaciee?a oai?eo eiio?ieueii? a?oie. Oae, ia 14-20
aeaiue e?eoaaiiy o oai?eo iniiaieo a?oi, ye? io?eioaaee eaoa?ii ii 2
iei. IAe a/i uiaeaiii, ai?no caaaeueiiai oa i?yiiai a?e??oa?io ciaioeany
ia 69% oa 90%; o oai?eo, ye? e?eoaaeeny eaoa?iiii ii 3 iei. IAe a/i
/a?ac aeaiue – ia 66% oa 79%, a o oai?eo eiio?ieueii? a?oie – eeoa ia
53% oa 66% a?aeiia?aeii. Ne?ae a?aei?oeoe, ui o oai?eo iniiaieo a?oi c
aaaeeith oa na?aaeiueiaaaeeith oi?iaie AA niinoa??aaeiny iia?eueia
cieaeaiiy ai?noo caaaeueiiai, i?yiiai a?e??oa?io, AeAO a oe?euei?e oa
?icaaaeai?e ne?iaaoeao e?ia? i?ae /an eaoa?iiioa?ai?? ia ia?o?e aeaeaae?
e?eoaaiiy oa a?eueo no??iea – a ae?oa?e aeaeaae? ?ioa?oa?iiioa?ai??.

A?aeiii, ui iia?/i? ae?? c?inoathoue i?yii i?iii?oe?eii aeic? i?aia?aoo,
aea, ine?eueee ie canoiniaoaaee iaaaeee? aeice eaoa?iio, oi a oe?eiio
oai?? eiai ia?aiineee aeia?a.

O 65,7 % iaoe??io?a iia?/ieo ?aaeoe?e ia aoei. O 47 (34,3 %) oai?eo
niinoa??aaany a?eiiiiae?aiee neiae?ii.

Iae/ano?oith iia?/iith ae??th aoea i??iaaiia ?aaeoe?y, yea aeieeaea ia
1-3 aaaaeaiiy /a?ac 6-8 aiaeei i?ney ?i’?eoe?? i?aia?aoo.

Aeey aea/aiiy iieaciee?a ee?oeiiiai ?ioi?oaoo iaie aoei ianoaaeaii 116
oai?eo na?aaeiueiaaaeeith oa aaaeeith oi?iaie AA, c yeeo 39 in?a
io?eioaaee eaoa?ii ii 2 iei. IAe a/i uiaeaiii, 36 – ii 3 iei. IAe a/i
/a?ac aeaiue, 41 oai?ee, ye? io?eioaaee aacenio oa?ai?th, neeaee
eiio?ieueio a?oio. Aeeoa?aioe?eiaaia aea/aiiy ?icaoeiooai?thth/eo
O-e?ioioeeo?a aeyaeei o oai?eo c na?aaeiueiaaaeeith oi?iith AA ia?o ca
ana aeinoia??ia ciaioaiiy caaaeueieo A-?OE, oa “aeoeaieo” A-?OE-O-ee?oei
c aenieith ao?ii?noth, yeei i?eieno?oueny ?ieue ?iaeoeoi?ieo ee?oei.

Iaea?eueo nooo?a? ci?ie a ?ioiieia?/iiio noai? aeyaeai? o oai?eo ia
aaaeeo oi?io AA, yea oa?aeoa?ecoaaeany cieaeaiiyi an?o iieaciee?a,
iniaeeai A-?OE oa Oo?.

Canoinoaaiiy eaoa?iio o oai?eo ia na?aaeiueiaaaeeo oi?io AA ye a aeic? 2
iei. IAe uiaeaiii, oae ? 3 iei. IAe /a?ac aeaiue, i?ecaiaeeei aei
i?aeaeuaiiy iieaciee?a A-?OE oa A-?OE-aeo (P<0,05) a ii??aiyii? c iieacieeaie eiio?ieueii? a?oie. I?e canoinoaaii? eaoa?iio i?e aaaee?e oi?i? AA ye a aeic? 2 iei. IAe uiaeaiii, oae ? 3 iei. IAe /a?ac aeaiue, aeinoia??ii (P<0,05) c?inoaea e?euee?noue A-?OE, A-?OE-aeo, Oo?. E?euee?noue Oo?-e?ioioeeo?a aeinoia??ii (P<0,05) c?inoaea o?eueee i?e aeei?enoaii? 2 iei. IAe a/i uiaeaiii. I?e e?eoaaii? oai?eo ia aaaeeo oi?io AA a?aei?/aeinue aeinoia??ia (P<0,05) c?inoaiiy iieaciee?a A-?OE, A-?OE-aeo. oa A-e?ioioeeo?a a ia?o?e oa ae?oa?e iniiaieo a?oiao a ni?anoaaeaii? c iieacieeaie eiio?ieueii? a?oie. Ae?aaiic aino?iai AA aoa aa??o?eiaaiee iayai?noth HBsAg o 217 oai?eo, a oaeiae HBeAg, aioe-HBe, aioe-HBcJgM oa G – o 54 oai?eo oa HBV-AeIE – o 50 oai?eo. Eiio?ieue ca aeeiai?eith ia?ea??a HBV aeicaieea iaea?eueo iiaii oa iaae?eii ioa?aeoa?ecoaaoe ia?aa?a ?ioaeoe?eiiai i?ioeano, aecia/eoe na?ieia?/iee i?io?eue oai?iai, a i?e i?iaaaeaii? i?ioea??onii? oa?ai?? – ia’?eoeaii ioe?ieoe ?? aoaeoeai?noue. I?e aeei?enoaii? eaoa?iio a eiiieaeni?e oa?ai?? oai?eo ia AA a aeic? 2 iei. IAe a/i eiaeiiai aeiy oa 3 iei. IAe a/i /a?ac aeaiue ye i?e aaaee?e, oae ? i?e na?aaeiueiaaaee?e oi?iao AA na?ieiiaa?n?y HBeAg ia aioe-HBe a?aeaoaaeany o an?o oai?eo iniiaieo a?oi ia iiiaio aeienee c noaoe?iia?o, a oaeiae ia aecia/aeanue HBV-AeIE a IE?. HBsAg i?e aeienoe? ?a?no?oaaany o 30,3% oai?eo c aaaeeith oi?iith AA, ye? io?eioaaee eaoa?ii ii 2 iei. IAe a/i eiaeiiai aeiy oa o 36,4% iaoe??io?a, ye? e?eoaaeeny eaoa?iiii ii 3 iei. IAe a/i /a?ac aeaiue; o 13,9% oai?eo c na?aaeiueiaaaeeith oi?iith AA, ye? io?eioaaee eaoa?ii ii 2 iei. IAe a/i eiaeiiai aeiy oa o 31,4% iaoe??io?a, ye? e?eoaaeeny eaoa?iiii ii 3 iei. IAe a/i /a?ac aeaiue. O oai?eo eiio?ieueii? a?oie c na?aaeiueiaaaeeith oi?iith AA ia iiiaio aeienee na?ieiiaa?n?y HBeAg ia aioe-HBe niinoa??aaeanue o 75% oai?eo, HBV-AeIE iiceoeaia i?iaeiaaeoaaea ?a?no?oaaoeny o 25% iaoe??io?a, a iiaia ae?i?iaoe?y HBsAg a?aeaoeany eeoa o 40% oai?eo. Na?aae iaoe??io?a eiio?ieueii? a?oie c aaaeeith oi?iith AA eeoa o 45% ca?a?no?iaaii cieeiaiiy HBsAg c e?ia?, o 70% oai?eo niinoa??aaeany na?ieiiaa?n?y HBeAg ia aioe-HBe oa o 80% iaoe??io?a ia?anoaea aeyaeyoeny HBV-AeIE a IE?. E?au? aeai? na?ieia?/iiai i?io?eth AA io?eiai? i?e canoinoaaii? i?ioea??oniiai i?aia?aoo – eaoa?iio a aeic? 2 iei. IAe a/i eiaeiiai aeiy o oai?eo c na?aaeiueiaaaeeith oa aaaeeith oi?iaie AA. Iaeiaioee a?aenioie oai?eo, o yeeo i?iaeiaaeoaaany ?a?no?oaaoeny HBsAg i?e aeienoe? neeaee oai?? c na?aaeiueiaaaeeith oi?iith AA, ye? io?eioaaee eaoa?ii ii 2 iei. IAe a/i eiaeiiai aeiy. Iaeiei c ia’?eoeaieo e?eoa???a ioe?iee aoaeoeaiino? e?eoaaiiy ? aea/aiiy ?ioa?oa?iiiaaiaco: ai?no ?OI a ne?iaaooe? e?ia? oa ni?iiiaei?noue eaeeioeeo?a aei ooai?aiiy ?OI. ?ioa?oa?iiiaee noaoon aecia/aee o 121 iaoe??ioa, c yeeo o 60 aoea aaaeea oi?ia AA, o 61 – na?aaeiueiaaaeea. 43 oai?ei c na?aaeiueiaaaeeith oi?iith AA i?ecia/aany eaoa?ii, i?e/iio 24 iaoe??ioa (I a?oia) io?eioaaee eiai ii 2 iei. IAe a/i eiaeiiai aeiy, 19 oai?eo (II a?oia) – ii 3 iei. IAe a/i /a?ac aeaiue. 40 iaoe??io?a c aaaeeith oi?iith io?eioaaee eaoa?ii: 20 c ieo – ii 2 iei. IAe a/i eiaeiiai aeiy (I a?oia) oa 20 oai?eo – ii 3 iei. IAe a/i /a?ac aeaiue (II a?oia). Eiio?ieueio a?oio neeaee 20 iaoe??io?a c aaaeeith oi?iith oa 18 – c na?aaeiueiaaaeeith oi?iith AA. Iieacieee ?ioa?oa?iiiaiai noaoono aeine?aeaeoaaeeny a aeeiai?oe? o?e/?: a ?iciae oai?iae aei ii/aoeo e?eoaaiiy, ia 7-10 aeaiue a?ae ii/aoeo e?eoaaiiy oa ia?aae aeieneith ?c noaoe?iia?o. Ii??aithth/e oeo?e ne?iaaoeiaiai ?OI, ??E oa oaiie ?o c?inoaiiy a iniiaieo a?oiao i?ae niaith ne?ae a?aei?oeoe, ui i?e na?aaeiueiaaaee?e oi?i? AA o oai?eo, ye? io?eioaaee eaoa?ii ii 2 iei. IAe eiaeiiai aeiy, oaiie c?inoaiiy oeo??a oee?eoethth/iai ?OI, ??E aoee aeinoia??ii oaeaeoeie (P<0,05), a oeo?e ?OI oa ??E aoee aeinoia??ii aeueie (P<0,05) a on? ia??iaee oai?iae, i?ae o iaoe??io?a, ye? io?eioaaee eaoa?ii ii 3 iei. IAe /a?ac aeaiue (?en. 1). O oai?eo I a?oie c aaaeeith oi?iith AA oaea ae caeiiii??i?noue niinoa??aaeanue eeoa /a?ac 7-10 aei?a a?ae ii/aoeo e?eoaaiiy, a i?ney anueiai eo?no ?ioa?oa?iiioa?ai?? a ia??iae ?aiiuei? ?aeiiaaeanoeaioe?? oeo? oee?eoethth/iai ?OI oa ??E o oai?eo c aaaeeith oi?iith AA I oa II a?oi aeinoia??ii ia a?ae??ciyeenue (P>0,05)
(?en. 2).

C iaoith ioe?iee aoaeoeaiino? e?eoaaiiy eaoa?iiii iaiao?aeia aoei
aea/aiiy aeecueeeo oa a?aeaeaeaieo iane?aee?a, ui aeiaaaea
niinoa?aaeaiiy ca oai?eie c aeeiai?/iei eiio?ieai ca ee?i?/iei
ia?aa?aii, a?io?i?/ieie iieacieeaie oa ia?ea?aie HBV-?ioaeoe?? i?ioyaii
1 ?ieo. O?eueee a oaeee no?ie iiaeeeai iiai?oa ioe?ieoe iane?aeee
aino?iai aaiaoeoo A – iaeoaeaiiy /e o?ainoi?iaoe?th a o?ii?/iee aaiaoeo.

Aiae?c aeecueeeo iane?aee?a AA iieacaa, ui o oai?eo, ye? io?eioaaee
eaoa?ii, a?aei?/aeinue a?eueo ni?eyoeeaa caaa?oaiiy aino?iai ia??iaeo
oai?iae oa ?aeiiaaeanoeaioe /ano?oa aeienoaaeeny aac caeeoeiaeo yaeu
(oaae.). Aeeiai?ea ee?i?/ieo oa a?io?i?/ieo iieaciee?a na?ae/eea i?i oa,
ui i?ioean ?aia?aoe?? caoyaoaaany ia aeiaoee no?ie o ?aeiiaaeanoeaio?a
eiio?ieueii? a?oie (?en. 3).

Oaaeeoey. *anoioa aeecueeeo iane?aee?a aaiaoeoo A o caeaaeiino? a?ae
oi?i aaaeeino? oa noaie e?eoaaiiy

A?oie oai?eoIane?aeeeNa?aaeiueiaaaeea oi?iaAaaeea oi?iainiiaia a?oia (i
– 71)eiio?ieueiainiiaia a?oia (i – 66) eiio?ieueiaI a?oia

(i-36)II a?oia

(i-35)a?oia (i-40)I a?oia

(i-33)II a?oia

(i-35)a?oia (i-40)aan. /enei%aan. /enei%aan. /enei%aan. /enei%aan.
/enei%aan.
/enei%A?ia?a?e??oa?iai?y1438.91028.62562.51030.31545.52870.0A?ia?o?ainoa
?acai?y1233.31337.12255.0927.31236.42767.5HBs-aioeaaiai?y513.91131.42460
.01030.31236.42255.0Caoyaeia
?aeiiaaeanoeaioe?y38.3514.31025.0412.1618.21640.0

*anoioa iin?enoaa HBsAg aeyaeeany o 4 ?ace iaioith a iniiai?e a?oi? –
2,2% – ii??aiyii c eiio?ieueiith – 8,8%. I?ioyaii 6-12 i?nyoe?a o 11
oai?eo eiio?ieueii? a?oie (13,8%), o 1 iaoe??ioa I iniiaii? a?oie (2,8%)
oa o 3 oai?eo II a?oie (4,4%) niinoa??aaeany o?ainoi?iaoe?y a o?ii?/iee
aaiaoeo (?en. 4).

Aiae?coth/e io?eiai? aeai? iiaeia c?iaeoe aeniiaie uiaei a?eueo aaeaei?
noaie i?ecia/aiiy eaoa?iio a aeic? 2 iei. IAe eiaeiiai aeiy ii??aiyii c?
noaiith – 3 iei. IAe /a?ac aeaiue. An? iieacieee aeecueeeo oa
a?aeaeaeaieo iane?aee?a i?ney canoinoaaiiy eaoa?iio a aeic? 2 iei. IAe
eiaeiiai aeiy o oai?eo ia AA na?aaeiueiaaaeeith oa aaaeeith oi?iaie
e?au? ii??aiyii c iieacieeaie i?ney eaoa?iiioa?ai?? a aeic? 3 iei. IAe
/a?ac aeaiue.

Iaaaaeai? iaoa??aee na?ae/aoue, ui canoinoaaiiy ?ioa?oa?iio a oa?ai??
oai?eo ia aino?ee a??oniee aaiaoeo A i?e i?aaeeueii anoaiiaeaieo
iieacaiiyo oa aaeaeaaoi?e iaoiaeeoe? e?eoaaiiy o aaaaoueio oai?eo
aeicaiey? iiia?aaeeoe o?ii?caoe?th i?ioeano. Aaaeeeai i?aee?aneeoe
ia?aaaaeiee oni?o i?e ii/aoeo e?eoaaiiy c?aco i?e anoaiiaeaii?
i?aeaeuaiiai ?eceeo o?ii?caoe?? ca aeaieie ia?aeiiiai ianoaaeaiiy
oai?eo.

AENIIAEE

1. Canoinoaaiiy eaoa?iio a eiiieaeni?e oa?ai?? a??oniiai aaiaoeoo A
nooo?ai aieeaaei ia ee?i?/i? i?iyae oa a?io?i?/i? iieacieee –
iie?auoaaany caaaeueiee noai oai?eo, i?enei?thaaeany ?aa?an?y ee?i?/ieo
oa a?io?i?/ieo i?iya?a (nei?i/oaaeany o?eaae?noue ?ioieneeaoe??,
aeiaoyie/iiai ia??iaeo, no?ie?a ianoaiiy aeia/iiai e?eco, ia?aaoaaiiy a
noaoe?iia??, oaeaeoa ciaiooaaeeny ai?no a?e??oa?io oa aeoeai?noue
aeai?iai?iio?ainoa?ace).

2. Iii?oi?eia ia?ea??a a??oniiai aaiaoeoo A a aeeiai?oe? iieacaa, ui i?e
aeei?enoaii? eaoa?iio a eiiieaeni?e oa?ai?? oai?eo ia AA nei??oa
nii/oa??aaeanue ae?i?iaoe?y HBsAg oa ia iiiaio aeienee o an?o oai?eo
noaaaea iaaaoeaiith HBV-AeIE a IE? ? a?aeaoaaeany na?ieiiaa?n?y HBeAg ia
aioe-HBe.

3. I?e aaiaoeo? A aeyaeaia ?ioiieia?/ia iaaeinoaoi?noue ii O-ee?oeiiiio
oeio, ui i?iyaeeany cieaeaiiyi caaaeueieo A-?OE oa iniiaieo ?aaoeyoi?ieo
eaioetha?a O-nenoaie ?ioi?oaoo. Oa?ai?y eaoa?iiii i?ecaiaeeea aei
ii?iae?caoe?? ?ioiii? a?aeiia?ae?.

4. Aeei?enoaiiy eaoa?iio a eiiieaeni?e oa?ai?? aaiaoeoo A noeioethaaei
?ioa?oa?iiiaaiac – i?ecaiaeeei aei i?aeaeuaiiy iieaciee?a ne?iaaoeiaiai
?ioa?oa?iio oa ?ioa?oa?iiiai? ?aaeoe?? eaeeioeeo?a.

5. Aeiaaio?eaaea aeeniaina?ia niinoa?aaeaiiy aeyaeei ciaioaiiy /anoioe
iin?enoaa HBsAg, caoyaeieo oi?i oa o?ii?caoe?? i?ioeano o oai?eo, ye?
io?eioaaee eaoa?ii; canoinoaaiiy 2-?OI ni?eyei iiia?aaeaeaiith
o?ainoi?iaoe?? AA a o?ii?/i? oi?ie.

6. Io?eiai? ?acoeueoaoe aeicaieeee cai?iiiioaaoe iioeiaeueiee aeai?eoi
canoinoaaiiy eaoa?iio o oai?eo c a?oi ?eceeo o?ii?caoe??.

Ia?ae?e ?ia?o, ui iioae?eiaai? ca oaiith aeena?oaoe??

1. Ee?i?ei-?ioiieia?/i? aniaeoe a??oniiai aaiaoeoo A // ?ioaeoe?ei?
oai?iae. – 1995. – ? 3. – N. 17-20 (o ni?aaao. c Aiae A.Ae., Oaoueyiei
I.A., Oaaei?/aiei N.A.).

2. Oa/aiea e enoiae ae?oniiai aaiaoeoa A o aieueiuo ia?eiiaieae //
A?a/aaiia aeaei. – 1996. – ? 5-6. – N. 119-123 (a niaao. n Oaoueyiei
I.A., A?iiaoaaneie E.E., Aiae A.Ae. e ae?.).

3. Eio?ii A a ea/aiee aieueiuo ae?oniuie aaiaoeoaie // Nia?aiaiiua
aniaeou aiaiiie iaaeeoeeiu. Nai?iee iao/iuo o?oaeia. – Eeaa, 1998. – N.
141-142 (a niaao. n Aiae A.Ae., Oaoueyiei I.A., Eeeiaiei AE.A.).

4. Ee?i?/i? aa??aioe aeaeueoa-?ioaeoe?? // ?ioaeoe?ei? oai?iae. – 1996.
– ? 2. – N. 44-48 (o ni?aaao. c Aiae A.Ae., Oaaei?/aiei N.A., Oaoueyiei
I.A.).

5. Eioa?oa?iiiaue noaoon o aieueiuo ae?oniui aaiaoeoii A, ea/aiiuo
eaoa?iiii // Nia?aiaiiua aniaeou aiaiiie iaaeeoeeiu. Nai?iee iao/iuo
o?oaeia. – Eeaa, 1998. – N. 258-260.

6. Eaoa?ii a eiiieaeniii ea/aiee aieueiuo ae?oniui aaiaoeoii A //
Eaoa?ii a e?eoaaii? iieieia?/ieo oa ?ioaeoe?eieo caoai?thaaiue
(iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? 15-16 eenoiiaaea 1995 ?. i.
??aia, iaeaniee iieieia?/iee aeeniaina?). – 1996. – N. 36-38 (a niaao. n
Aiae A.Ae., Oaoueyiei I.A., Ia?e/aaui E.E. e ae?.).

7. Aeanyoe??/iee aeina?ae canoinoaaiiy ?aeiia?iaioieo aaiii?iaeaia?ieo
aeueoa-?ioa?oa?ii?a i?e a??onieo aaiaoeoao // Iaoa??aee V c’?caeo
?ioaeoe?ii?no?a Oe?a?ie. – Oa?iii?eue, 1998. – N. 28-30 (o ni?aaao. c
Aiae A.Ae., Oaoueyiei I.A., Oaaei?/aiei N.A. oa ?i.).

8. Iaoiae i?eiaiaiey ?aeiiaeiaioiiai eioa?oa?iia aeueoa-2a (Eio?iia A)
i?e o?iie/aneii ae?oniii aaiaoeoa N // Eioi?iaoeeiiiia ienueii ? 18-98 i
iiaiaaaaeaieyo a neoaia cae?aaiio?aiaiey. Aui. 2. – Eeaa. – 1998. – 2 n.
(a niaao. n Aiae A.Ae., Aioiiaiei N.A., Eeeiaiei AE.A. e ae?.).

9. I?eiaiaiea eaoa?iia i?e AAA // Eioi?iaoeeiiiia ienueii ? 95. – Eeaa.
– 1997. – 2 n. (a niaao. n Aiae A.Ae., Oaoueyiei I.A.,
A?iiaoaaneie E.E. e ae?.).

10. Aaiii?iaeaia?iee aeueoa-2a-?aeiia?iaioiee ?ioa?oa?ii (eaoa?ii) o
eiiieaeniiio e?eoaaii? oai?eo ia aino?ee a??oniee aaiaoeo A // Iiaa o
ae?aaiinoeoe? oa e?eoaaii? oai?eo ia aino?ee a??onieo oai?ia (iaoa??aee
iaoeiai-i?aeoe/ii? eiioa?aioe?? ? Ieaioio Anioe?aoe?? ?ioaeoe?ii?no?a
Oe?a?ie). – Noie-Oa?iii?eue, 1997. – N. 6-7 (a ni?aaao. c Aiae A.Ae.,
Oaoueyiei I.A.).

11. Eaoa?ii a eiiieaeniiio e?eoaaii? aaiaoeoo A // ?ioaeoe?ei? oai?iae:
Ca. iaoe. i?. Aei. V. – Euea?a: “Aneoeai”, 1997. – N. 24-25.

12. A??oniee aaiaoeo o oai?eo ia ia?eiiai?th // ? ioaeoe?ei? oai?iae:
Ca. iaoe. i?. Aei. I. – Euea?a: “Aneoeai”, 1994. – N.18-19 (a ni?aaao. c
Oaoueyiei I.A., Aiae A.Ae., A?iiaoaanueeith E.E. oa ?i.).

13. Ee?i?/i? iniaeeaino? aeaeueoa-aaiaoeoo // ? ioaeoe?ei? oai?iae: Ca.
iaoe. i?. Aei. I. – Euea?a: “Aneoeai”, 1994. – N. 7-8 (a ni?aaao. c Aiae
A.Ae., Oaoueyiei I.A., A?iiaoaanueeith E.E. oa ?i.).

14. Canoinoaaiiy aeueoa-2a ?aeiia?iaioiiai ?ioa?oa?iio (eaoa?iio) i?e
a??oniiio aaiaoeo? A // ?ioaeoe?ei? oai?iae: Ca. iaoe. i?. Aei. III. –
Euea?a: “Aneoeai”, 1995. – N. N. 14-15 (a ni?aaao. c Aiae A.Ae.,
OaoueyieiI.A., A?iiaoaanueeith E.E. oa ?i.).

15. Immunopathology of virus Hepatitis Type B // Materials of 7
International Congress for Infectious Diseases. – Hong Kong, 1996. – P.
253-254 (with Vovk A.D., Fedorchenko S.V., Tatyanko N.V. et al.).

AIIOAOe??

Eyoie I.A. Oa?aiaaoe/aneay yooaeoeaiinoue eaoa?iia a eiiieaeniii ea/aiee
aieueiuo ino?ui ae?oniui aaiaoeoii A. – ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.13 – eioaeoeeiiiua aieacie. – Eeaaneee IEE
yieaeaieieiaee e eioaeoeeiiiuo aieaciae ei. E.A. A?iiaoaaneiai, Eeaa,
1999.

A aeenna?oaoeee eceiaeaiu aeaiiua enneaaeiaaiey oa?aiaaoe/aneie
yooaeoeaiinoe eaoa?iia ii ?acoeueoaoai eeeie/aneeo, aeioeie/aneeo,
na?ieiae/aneeo, eiioiieiae/aneeo enneaaeiaaiee, iieacaoaeae
eioa?oa?iiiaaiaca o 217 aieueiuo ino?ui aaiaoeoii A. Iaaethaeaiey
i?iaiaeeeenue a aeeiaieea – ai a?aiy ea/aiey – a ioaeaeaiee ae?oniuo
aaiaoeoia, iinea auienee a oa/aiee aiaea – a
aeeniaina?ii-iieeeeeie/aneii ioaeaeaiee EIEEYEA.

Enneaaeiaaiey iieacaee, /oi a ia?eiae ?acaa?a aeaeoooe a eeeie/aneie
ea?oeia eae i?e oyaeaeie, oae e i?e n?aaeiaoyaeaeie oi?iao AA,
i?aiaeaaeaee iauaeioaeoeeiiiue, a?o?aeae/aneee, aeeniaioe/aneee
neiae?iiu e ea/aiea eaoa?iiii aieueiuo AA i?iaiaeeee e nie?auaieth
aeeeoaeueiinoe ia?a/eneaiiuo eeeie/aneeo neiioiiia a n?aaiaiee n
iieacaoaeyie eiio?ieueiie a?oiu. I?e yoii auyaeaiu aieaa au?aaeaiiua
eciaiaiey eeeie/aneiai oa/aiey i?e eniieueciaaiee eaoa?iia ii 2 iei. AAe
a/i /a?ac aeaiue eae i?e oyaeaeie, oae e i?e n?aaeiaoyaeaeie oi?ia AA.

Neaaeoao ioiaoeoue, /oi o aieueiuo iniiaiuo a?oii n oyaeaeie e
n?aaeiaoyaeaeie oi?iie AA ia ia?aie aeaeaaea eioa?oa?iiioa?aiee
iaaethaeaeinue iinoaiaiiia nieaeaiea eiee/anoaa aeee?oaeia e aeoeaiinoe
aeaieiaieiio?ainoa?acu, a ia aoi?ie aeaeaaea ea/aiey eaoa?iiii – aieaa
no?aieoaeueii.

Aeeooa?aioee?iaaiiia eco/aiea ?icaoeiia?acothueo O-eeioioeeoia auyaeei o
aieueiuo ni n?aaeiaoyaeieie oi?iie AA aeinoiaa?iia nieaeaiea iaueo –
A-?IE e aeoeaiuo A-?IE-O-eeaoie n aunieie aoeiiinoueth, eioi?ui
i?eienuaaeanue ?ieue eiaeoeoi?iuo eeaoie.

Aieaa nouanoaaiiua eciaiaiey auyaeaiu o aieueiuo n oyaeaeie oi?iie AA,
eioi?ay oa?aeoa?eciaaeanue nieaeaieai anao iieacaoaeae, iniaaiii A-?IE e
OO?.

I?eiaiaiea eaoa?iia o aieueiuo ni n?aaeiaoyaeaeie oi?iie AA eae a aeica
2 iei., oae e 3 iei. AAe a/i, i?eaiaeeei e aeinoiaa?iiio iiauoaieth
iieacaoaeae A-?IE e A-?IE-aeo, n?aaieaieoaeueii n aeaiiuie eiio?ieueiie
a?oiiu. I?e ea/aiee aieueiuo oyaeaeie oi?iie AA ioia/aeinue aeinoiaa?iia
oaaee/aiea iieacaoaeae A-?IE. A-?IE-aeo. e A-eeioioeeoia a iaaeo
iniiaiuo a?oiiao, n?aaieoaeueii n aeaiiuie eiio?ieueiie a?oiiu.

Eo/oea ?acoeueoaou na?ieiae/aneiai i?ioeey iieo/aiu i?e eniieueciaaiee
eaoa?iia a aeica 2 iei. AAe a/i eaaeaeue aeaiue.

Iieacaoaee eioa?oa?iiiaiai noaoona enneaaeiaaeenue a aeeiaieea o?eaeaeu:
a ?acaa? aieacie, ia 7-10 aeaiue ea/aiey e ia?aae auieneie ec
noaoeeiia?a. O aieueiuo ni n?aaeiaoyaeaeie AA, ea/aiiuo eaoa?iiii ii 2
iei. AAe a/i aaeaaeiaaii, oaiiu ?inoa e oeo?u E?E e oee?eoee?othuaai EOI
auee aeinoiaa?ii aieaa auno?uie e aunieeie ai ana ia?eiaeu aieacie ii
n?aaiaieth n iieacaoaeyie II iniiaiie e eiio?ieueiie a?oii, a o aieueiuo
oyaeaeie oi?iie AA oaeay aea caeiiiia?iinoue iaaethaeaeanue oieueei ia
7-10 aeaiue ea/aiey.

Aeaiiua i aeeceeo e ioaeaeaiiuo enoiaeao AA iicaieeee ii?aaeaeeoue aieaa
oaea/ioth noaio i?eiaiaiey eaoa?iia a aeica 2 iei. AAe a/i aaeaaeiaaii.

Eeth/aaua neiaa: aaiaoeo A, eaoa?ii, ea/aiea, yooaeoeaiinoue,
eioa?oa?iiiaaiac, ia?ea?u, eiioiiue noaoon.

Eyoie I.A. Oa?aiaaoe/ia aoaeoeai?noue eaoa?iio a eiiieaeni?e oa?ai??
oai?eo ia aino?ee a??oniee aaiaoeo A. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.13 – ?ioaeoe?ei? oai?iae. – Ee?anueeee IAe?
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai, Ee?a,
1999.

A aeena?oaoe?? aeeeaaeai? ?acoeueoaoe ee?i?/ieo, a?io?i?/ieo,
na?ieia?/ieo, ?ioiieia?/ieo aeine?aeaeaiue, aeai? ?ioa?oa?iiioa?ai?? o
217 oai?eo ia aino?o oi?io a??oniiai aaiaoeoo A.

Niinoa?aaeaiiy i?iaiaeeeeny a aeeiai?oe? – i?ae /an e?eoaaiiy a
a?aeae?eaii? a??onieo aaiaoeo?a; i?ney aeienee c noaoe?iia?o a
aeeniaina?ii-iie?ee?i?/iiio a?aeae?eaii? EIAe?A?O.

Canoinoaaiiy eaoa?iio a eiiieaeni?e oa?ai?? oai?eo ia AA iiceoeaii
aieeaaei ia ee?i?/i? i?iyae oa a?io?i?/i? iieacieee. I?e aeei?enoaii?
eaoa?iio oaeaeoa a?aeaoaaeanue ae?i?iaoe?y HBsAg, ii?iae?coaaeeny
iieacieee ?ioiii? a?aeiia?ae ca aeaieie O-ee?oeiii? ?aaeoe??. Eaoa?ii
noeioeth? ?ioa?oa?iiiaaiac.

Aeeniaina?ia niinoa?aaeaiiy aeyaeei ciaioaiiy /anoioe iin?enoai HBsAg,
caoyaeieo oi?i oa o?ii?caoe?? i?ioeano o oai?eo, ye? io?eioaaee eaoa?ii.

Eeth/ia? neiaa: aaiaoeo A, eaoa?ii, e?eoaaiiy, aoaeoeai?noue,
?ioa?oa?iiiaaiac, ia?ea?e, ?ioiiee noaoon.

Ljashok O.V. Therapeutic effectivity of laferon on complex treatment of
patients on acute virus Hepatits type B. — Manuscript.

Thesis for candidate’s degree by speciality 14.01.13 — infections
diseases. — Kiev Scientific and Research Institute of epidemiology and
infectious diseases named by L.V. Gromashevsky, Kiev, 1999.

The dissertation shows aspects of clinical, biochemical, serological,
immunological investigations, interferonstatus of 217 patients on acute
virus Hepatitis type B.

Investigations were provided during one year after check-out from the
hospital in the Kiev Scientific and Research Institute of epidemiology
and infections diseases.

Using interferon therapy improve clinical end biochemical results. To
the end of interferon course more early eliminate HBsAg and normalize
immunity response, according T-cells reaction.

Interferon therapy stimulates of interferonogenesis.

Outcome during one year shows patients treated by interferon have more
low HBsAg-carriers and transformate to chronically.

Key words: hepatitis type B, laferon, treatment, effectivity,
interferonogenesis, markers, immune status.

Aeneiaethth ue?o iiaeyeo aeieoi?o iaaee/ieo iaoe, i?ioani?o,
Caneoaeaiiio ae?y/aa? iaoee ? oaoi?ee Oe?a?ie Ethaia? Eaiio??ai?
A?iiaoaanuee?e ca iino?eio aeiiiiiao i?e aeeiiaii? aeena?oaoe?eii?
?iaioe.

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