I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y

?i. ?.ss. Ai?aa/aanueeiai

Aeiaaaethe Oaoyia sse?aia

OAeE 577. 121.3-034. 4:616. 71

NO?OEOO?II-OOIEOe?IIAEUeI? CI?IE A AeIAAEO O?OA*ANOEO E?NOEAO NEAEAOA
A?EEO UO??A I?E Ae?? IA I?AAI?CI NAEIOeAAI? ?IOIENEEAOe??

14.03.01 — ii?iaeueia aiaoii?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

OA?III?EUe — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia o Aieeinueeiio aea?aeaaiiio oi?aa?neoao? ?iai? Ean?
Oe?a?iee oa o a?aeae?e? oeeoieia?? oa a?noiaaiaco ?inoeoooo
ciieia??? ?iai? ?.?. Oiaeueaaocaia AI Oe?a?ie

Iaoeiaee ea??aiee: Aeieoi? iaaee/ieo iaoe, i?ioani?

Ieeaethe Aaneeue Noaiaiiae/ —

Aieeinueeee aea?aeaaiee oi?aa?neoao ?iai? Ean?

Oe?a?iee,

i?ioani? eaoaae?e aiaoii?? ?
o?c?ieia?? ethaeeie

Io?oe?ei? iiiiaioe:

Aeieoi? a?ieia?/ieo iaoe, i?ioani?

Eiaooi Ieoaeei Oio?eiae/ — ?inoeooo ciieia?? ?iai? ?.?. Oiaeueaaocaia AI
Oe?a?ie, caa?aeoaa/ a?aeae?eo aaiethoe?eii? ii?oieia?? o?aaaoieo;

Aeieoi? a?ieia?/ieo iaoe, i?ioani?

I?neoi ?a?na Iao??aia — A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao
?iai? I.?. Ie?iaiaa IIC Oe?a?ie, caa?aeoaa/ eaoaae?e iaaee/ii? a?ieia??.

I?ia?aeia onoaiiaa:

?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie, eaoaae?a
ii?iaeueii? aiaoii??, i.?aaii-O?aie?anuee

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 8 ” aeiaoiy 1999 ?. i 16 aiae. ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 58.601.01 o Oa?iii?euenuee?e
aea?aeaai?e iaaee/i?e aeaaeai?? ?i. ?.ss. Ai?aa/aanueeiai (282001, i.
Oa?iii?eue, iaeaeai Aie?, 1).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?iii?euenueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss.Ai?aa/aanueeiai (282001, i.
Oa?iii?eue, aoe. ?onueea, 12).

Aaoi?aoa?ao ?ic?neaiee “ 7 ”aa?aniy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaae. iaoe, i?ioani?
E?o I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. No/aniee aoai ?icaeoeo ii?oieia??
oa?aeoa?eco?oueny i?aaiaiiyi aei aea/aiiy no?oeoo?ieo iniaeeainoae
oeaiei, i?aai?a oa ?o nenoai ye ii?oieia?/ii? iniiae ??cieo ooieoe?e
i?aai?cio (Eoi??yiia A.A., 1993). Inoaii?i /anii c??n iaoeiaee ?ioa?an
aei ieoaiue ooieoe?iioaaiiy e?noeiai? nenoaie. Aeiaaaeaii, ui naia
neaeao oa?aeoa?eco?oueny ae?aaeaiith ieanoe/i?noth, eiio aeanoeaa
/ooeeaa ?aaeoe?y /a?ac iai?ii? i?ioeane ia aieea aeciaaiieo o?i?/ieo
oaeoi??a.

Ia nueiaiaei?oi?e aeaiue aaea iaa?iiaaeaeaii cia/iee iaoa??ae i?i aieea
aeayeeo ciai?oi?o oaeoi??a ??cii? ao?ieia?? ia ii?oi-ooieoe?iiaeuei?
ci?ie o e?noeia?e nenoai? (Iaaeinooi I.O., 1989; ?iae?iiiaa I.A.,
1989-1997; N?ei?a A.C., 1995, 1998; Eiaaoi?eia A.A., 1975-1998; Aieioei
A.Ae., 1995; ?ai?iaoeueeee A.ss., 1995; E?aaoe?a N.?., 1995; ?iiaithe
A.I., 1996; Aaeauoe ss.O., 1996; Ao?aa?o I.Ae., 1996; Oeaeae I.I.,
1997; Oiaae?a I.A., 1998; Ieeaethe A.N., 1981-1998; Oaaeiithe ss.?.,
1979-1998; I?neoi ?.I., 1998; Ne?ya?ia I.I.,1998; Eoie? A.A., 1998;
Eoc?i A.?., 1998; Iaa?e/ A.A., 1998).

Iaeiae i?iaeaia aieeao aeieia?/ieo oaeoi??a ia aoaeiao, ??no ?
oi?iiooai?aiiy e?noie neaeaoa, aeey yeeo oa?aeoa?iee oe?ieee ?
??ciiiai?oiee niaeo? aieeao ia ooieoe?? oa no?oeoo?o ??cieo nenoai
i?aai?cio, ? iaaeinoaoiuei ae??oaiith. Iaeiei ?c oaeeo oaeoi??a ?
o?i?/i? ?a/iaeie, aei yeeo iaeaaeaoue aaaee? iaoaee. A ioi/oth/a
na?aaeiaeua aaaee? iaoaee iio?aieythoue c i?aei?e?inoa eieuei?iai?
iaoaeo?a??, ?iaeiaeu ei?enieo eiiaeei, o?i?/ieo i?aei?e?inoa,
aaoiiia?eueiiai o?ainii?oo oiui (Oeoeeiaa A.I., 1992; *oiae A.I., 1995;
?aiaoiaa I.N., 1997).

Iioe?aiei caa?oaeithth/ei o?i?/iei aeaiaioii ? naeiaoeue ? eiai
niieoee. A inoaii? ?iee i?iaaaeaii ?yae aeine?aeaeaiue, ye? aeiaiaeyoue
iiaeeea?noue aieeao ia inoaiaaii? i?ioeane naeioeaai? ?ioieneeaoe??
(Iaaeoaa I.I., 1991; ?iae?iiiaa I.A., 1996; N?ei?a A.C., 1998). A?aeiii,
ui a i?aai?ci? o aeaeyae? oinoi?ii-eaeueoe??aeo niieoe naeiaoeue
a?aeeeaaea?oueny a ??cieo i?aaiao ? oeaieiao, ia?aaaaeii iaeiie/oth/enue
a e?noeia?e. Aea iaa?aeiii, yeee aieea ni?e/eiy? oeae aeaiiiiaaiee
aaaeeee iaoae ia no?oeoo?o e?noeiai? oeaieie, ia ??no, i?ie?oa?aoe?th oa
oi?iiooai?aiiy aeiaaeo o?oa/anoeo e?noie neaeaoa, oi/ oaea eiiieaenia
aeine?aeaeaiiy ?aaeoe?e e?noeiai? nenoaie i?e iaaeoiaeaeaii? naeioeth ?
eiai nieae a i?aai?ci ia? nooo?aa cia/aiiy ye aeey a?ieia??, oae ? aeey
iaaeeoeeie. Ia iniia? oeueiai aoei noi?ioeueiaaii iaoo aeaiiai
aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa aeeiiaia
a?aeiia?aeii aei oaiaoe/iiai ieaio iaoeiaeo aeine?aeaeaiue Aieeinueeiai
aea?aeaaiiai oi?aa?neoaoo ?i. Ean? Oe?a?iee a ?aieao aea?aeathaeaeaoii?
oaie “?ic?iaea ?ano?iai-aeaeo?iiii-i?e?ineii?/ieo
noa?aieiai-noa?aiiao?e/ieo iaoiae?a i?e?i-ii?oino?oeoo?ieo
aeine?aeaeaiue a?eiaeo iniaeeainoae aoaeiae e?noee i?ae aieeaii
aeiaio?iiiaaiieo oaeoi??a”, iiia? aea?aeaaii? ?a?no?aoe?? 0196U006628.

Iaoa aeine?aeaeaiiy. Aea/eoe iniaeeaino? no?oeoo?ii-ooieoe?iiaeueieo
ci?i a o?oa/anoeo e?noeao neaeaoa a?eeo uo??a a oiiaao ?ioieneeaoe??
i?aai?cio niieoeaie naeioeth.

Aeey aeinyaiaiiy iaoe aeine?aeaeaiiy aoei aecia/aii oae? caaea/?:

1. Aea/eoe ci?ie a aoaeia? ? a?noino?oeoo?? o?oa/anoeo e?noie e?ioe?aie
i?e naeioeaa?e ?ioieneeaoe??.

2. Aeaoe ioe?ieo i?ioean?a i?ie?oa?aoeaieo aeanoeainoae inoaiaaiieo
ee?oei a ciiao inoaiaaiaco i?e ii?aaeaii? i?aai?cio nieyie naeioeth.

3. Aeine?aeeoe iniaeeaino? a?ineioaca eieaaaiiaeo a?ee?a ?
ae?eicai?iiae?eai?a a caiao aeoeaiiai inoaiaaiaco i?e ae?? naeioeaai?
?ioieneeaoe?? c aeei?enoaiiyi iaoiaeo ?aae?iaaoia?ao??.

4. Anoaiiaeoe neaeaoi? no?oeoo?e, ye? caeaoi? aei aeaiiioaaiiy
naeioeth.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Ca aeiiiiiaith eiiieaeno
no/anieo iaoiae?a (inoaiiao?e/iiai, a?noieia?/iiai, ii?oiiao?e/iiai,
?aae?i?cioiiiiai, iaoaiaoe/iiai) aeine?aeaeaiiy a aenia?eiaioao io?eiai?
iia? aeai? i?i iniaeeaino? ci?ie a no?oeoo?? aeiaaeo o?oa/anoeo e?noie,
a oaeiae i?i ii?ooaiiy a ieo ?ioaineaiino? ?inoiaeo oa inoaiieanoe/ieo
i?ioean?a a oiiaao ?ioieneeaoe?? i?aai?cio naeioeai.

Aeyaeai? /ooeea? oa iaeneiaeueii ?aiei? ooieoe?iiaeuei? no?oeoo?e e?noie
neaeaoa (iaoaai?o?ca?ia ieanoeiea ?inoo oa ia??inoaeueia ciia ae?ao?co)
i?e inoaioiene/i?e ae?? naeioeth.

Aia?oa c’yniaaii aeaye? iaoai?cie ii?ooaiue, ui aeieeee a no?oeoo?ao
e?noee; aeine?aeaeaii iniaeeaino? i?ie?oa?aoeaieo i?ioean?a, ye?
i?ioiaeyoue o ciiao ?inoo, aea/aii iniaeeaino? a?ineioaco eieaaaiiaeo
a?ee?a ? noeueoaoiaaieo ae?eicai?iiae?eai?a i?e naeioeaa?e
?ioieneeaoe??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. A aenia?eiaio? aeyaeaii
ii?oi-ooieoe?iiaeuei? ci?ie o aeiaaeo o?oa/anoeo e?noeao neaeaoa i?e
o?c?ieia?/ieo oiiaao ?nioaaiiy, iia’ycaieo ?c io?o?iiyi i?aai?cio
aaaeeeie iaoaeaie, cie?aia nieyie naeioeth, ui ia? aaaeeeaa cia/aiiy o
aeai?? iaoiae?a aaeaeaaoii? oa?ai?? e?eoaaiiy naeioeaaeo io?o?iue i?e
i?ioan?eieo caoai?thaaiiyo.

Io?eiai? ii?oieia?/i? aeai? iathoue ?noioia cia/aiiy aeey ?ic?iaee
e?eoaaeueii-i?io?eaeoe/ieo caoiae?a c iaoith caiia?aaiiy ?icaeoeo
iaoieia?/ieo i?ioean?a oa iiaeeaeaiith ci?i o aeiaaeo o?oa/anoeo e?noeao
i?ney naeioeaai? ?ioieneeaoe??.

Iniiai? iieiaeaiiy oa aeniiaee aeena?oaoe?eii? ?iaioe ai?iaaaeaeaii a
iaa/aeueiee i?ioean ? iaoeia? aeine?aeaeaiiy ii?oieia?/i?o oa
a?a??i?/ieo eaoaae? Aieeinueeiai aea?aeaaiiai oi?aa?neoaoo ?i. Ean?
Oe?a?iee, Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo,
Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss.
Ai?aa/aanueeiai.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii i?iaaaeai? iniiai?
ii?oi-ooieoe?iiaeuei? aeine?aeaeaiiy, aiae?c a?noii?aia?ao?a ?
a?noiaaoia?ao?a, noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiiy, a
oaeiae ?o ocaaaeueiaiiy. ?ioa?i?aoaoe?y io?eiaieo ?acoeueoao?a, iniiai?
iieiaeaiiy, ui aeiinyoueny ia caoeno, oa aeniiaee aeena?oaoe??
noi?ioeueiaai? aaoi?ii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?eii? ?iaioe
ai?iaiaaii ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo Aieeinueeiai aea?aeaaiiai
oi?aa?neoaoo ?i. Ean? Oe?a?iee (Eooeuee, 1997-1999), ?? Iaoe?iiaeueiiio
eiia?an? aiaoii?a, a?noieia?a, aia??ieia?a ? oiiia?aoiaiaoii?a
“Aeooaeuei? ieoaiiy ii?oieia??” (Eoaainuee, 1998), Anaoe?a?inueei?
iaoeiai? eiioa?aioe?? “I?iaeaie a?eiai? o?c?ieia??” (Eooeuee, 1998), ia
?icoe?aiiio can?aeaii? eaoaae?e aiaoii?? ? o?c?ieia?? ethaeeie
Aieeinueeiai aea?aeaaiiai oi?aa?neoaoo ?iai? Ean? Oe?a?iee (Eooeuee,
1999).

Ioae?eaoe??. Iniiaiee ci?no aeaieo aeine?aeaeaiue a?aeia?aaeaii o 6
iaoeiaeo i?aoeyo, c ieo 4 – o iaoeiaeo oaoiaeo aeaeaiiyo, 1 – o ca??ieeo
noaoae, 1 – o iaoa??aeao eiioa?aioe??.

No?oeoo?a ? ianya aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeaii ia 157
noi??ieao iaoeiiieniiai oaenoo. ?iaioa aeeth/a? anooi, aiae?oe/iee
iaeyae e?oa?aoo?e, ?icae?e “Iaoa??aee oa iaoiaee aeine?aeaeaiiy”,
?icae?e aeanieo aeine?aeaeaiue, aiae?c ? ocaaaeueiaiiy ?acoeueoao?a
aeine?aeaeaiue, aeniiaee, i?aeoe/i? ?aeiiaiaeaoe??, nienie aeei?enoaieo
aeaea?ae. Aeena?oaoe?eia ?iaioa ?ethno?iaaia 33 ?enoieaie, 17
oaaeeoeyie. Ia?ae?e aeei?enoaieo e?oa?aoo?ieo aeaea?ae i?noeoue 229
iaeiaioaaiue, o oiio /ene? 69 ca?oa?aeieo.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. Aeine?aeaeaiiy i?iaaaeaii ia 176
a?eeo uo?ao-naioeyo e?i?? A?noa? (/enoeo ?ia?eaeeiaiaaieo e?i?e), a?eii
6 i?nyoe?a. Oe? oaa?eie c?o/i? aeey aea/aiiy inoaiaaiaco iayai?noth
aacia?a?aiiai ?inoo ? oa?aeoa?ieie iaeiioeiieie ?aaeoe?yie ia aieea
??ciiiai?oieo oaeoi??a.

?iaioa aeeiiaia ia iaoa??aeao aeine?aeaeaiue, ye? aoee i?iaaaeai?
a?aeae?eii oeeoieia?? ? a?noiaaiaco ?inoeoooo ciieia?? ?iai? ?.?.
Oiaeueaaocaia AI Oe?a?ie (caa. a?aeae?eii aeieoi? a?ieia?/ieo iaoe,
i?ioani? ?iae?iiiaa I.A.). Aeey aeine?aeaeaiiy oiiaeaie a?aeae?eo
oeeoieia?? ? a?noiaaiaco iaaeai? ia?ao?iia? aeiee, a?noii?aia?aoe,
a?noiaaoia?aoe. Iaie aoei aeaioiaeaii i?aia?aoe aeey ii?oi- ?
inoaiiao?e/iiai aeine?aeaeaiiy, a oaeiae i?aia?aoe eiio?ieueieo a?oi
oaa?ei. I?iaaaeaiee aiae?c a?noii?aia?ao?a oa a?noiaaoia?ao?a.

Uiaeaiii c ?aeath uo?ai aaiaeeee aoeaoao naeioeth aeicith 10 ia/ea iane
o?ea o aeaeyae? 1%-ai aiaeiiai ?ic/eio i?ioyaii 3,5 i?nyoe?a (105 ae?a).
Oaa?eiai eiio?ieueii? a?oie aaiaeeee aeenoeeueiaaio aiaeo. Noia?ia aeica
io?othaaiiy uo??a aoeaoaoii naeioeth aeecueea aei oeo eiioeaio?aoe?e,
ye? ciaoiaeyoueny a i?e?iaeiiio na?aaeiaeu?.

An?o oaa?ei aoei iiae?eaii ia 5 a?oi ii aea? na??? a eiaei?e a?oi?
(eiio?ieueia ? i?aeaeine?aeia). I?ney cae?i/aiiy aenia?eiaio?a
cae?enithaaee caa?? iaoa??aeo aeey aeine?aeaeaiiy. Oaa?ei aeaiaeeee ?c
aenia?eiaioo i?ae ao??iei ia?eicii iaoiaeii aeaeai?oaoe?? c ianooiiei
neaeaooaaiiyi. Aeae?eyee aeiaa? o?oa/ano? e?noee caaeiuei? e?ioe?aee
(noaaiia? e?noee), o?enoaaee a 10%-io iaeo?aeueiiio oi?iae?i?.

Canoiniaoaaee iaoiaee inoai- ? ii?oiiao???. Ooaiaaioee?eoeai c oi/i?noth
aei 0,01 ii i?iaiaeeee inoaiiao??th ca iaoiaeeeith W. Duerst. Aeey
aeiaaeo o?oa/anoeo e?noie e?ioe?aee aecia/aee oae? iieacieee: iaea?eueoo
oe?eio aeenoaeueiiai ai?o?co, iaea?eueoo oe?eio na?aaeeie ae?ao?co.

Aiooaaee a?noieia?/i? iiacaeiaaei? c??ce oiaueiith 4-6 iei. Aeey
oa?aoaaiiy i?aia?ao?a canoiniaoaaee aaiaoienee?i Iae??a-o?ii?i-aicei.

Ii?oiiao?e/i? aeine?aeaeaiiy ae?ao?co, aeenoaeueiiai ai?o?co aeiaaeo
o?oa/anoeo e?noie i?iaiaeeee ca iaoiaeeeith A.A. Aaoaiaeeeiaa ca
aeiiiiiaith aaeioiaiai i?e?iiao?a IIA-1-15o oa noaiaea?oii? n?oee
?IA?-3.

Aeey oa?aeoa?enoeee ai?o?ca?iiai o?yua aeei?enoiaoaaee eeaneo?eaoe?th
cii A.A. Eiaaoi?eiaa, yea ? iaea?eueo aaeaioiaaia aei iienaiiy ci?i
ai?o?ca?iiai o?yua i?ae aieeaii aeciaaiieo oaeoi??a. Ii?oiiao??th
aeenoaeueieo ai?o?c?a aeiaaeo o?oa/anoeo e?noie i?iaiaeeee ca oaeith
i?ia?aiith: aecia/aee oe?eio ai?o?ca?iiai o?yua, oe?eio ciie
?iaeeoa?aioiiai o?yua, oe?eio ciie i?ie?oa?aoe??, oe?eio ciie
aeao?i?oeaiiai o?yua, aeiaaeeio o?aaaeoe ia?aeiii? niiia?ice,
e?euee?noue i?ie?oa?oth/eo ee?oei o noiai/eeao ciie i?ie?oa?aoe??, a
oaeiae aei??thaaee oe?eio noaeiaiaiai o?yua.A aoa/ao?e e?nooe?
i?ae?aoiaoaaee e?euee?noue inoaiaeano?a o ia?aeii?e niiia?ic?.

O i?ia?aio ii?oiiao??? ae?ao?co aeeth/aee oae? iieacieee: oe?eia
ciai?oiueiai oa?o ia??inoo, oe?eia aioo??oiueiai inoaiiiiai oa?o
ia??inoo, e?euee?noue inoaiaeano?a a aiaeino?, e?euee?noue inoaiaeano?a
o ia??ino?.

Aeey oeueo?ano?oeoo?ieo aeine?aeaeaiue eoni/ee e?noee o?enoaaee a
2,5%-io ?ic/ei? aethoa?aeueaeaa?aea ia 0,1 I oinoaoiiio aooa??.
?icaeyaeaee a aeaeo?iiieo i?e?ineiiao AAI-100EI oa AAI-100E.

Aeey aeine?aeaeaiiy aeoeaiino? ?inoiaeo i?ioean?a, ee?oeiii?
i?ie?oa?aoe??, iaoaaie?/ieo aeanoeainoae inoaiaaiieo ee?oei ? ?o o/ano?
a i?iaeoeoaaii? eiiiiiaio?a e?noeiaiai iao?eeno aoa canoiniaaiee iaoiae
?aae?iaaoia?ao??. Iaoiae aaco?oueny ia aaaaeaii? a ia’?eo, yeee
aeine?aeaeo?oueny, ?aae?iaeoeaiiai iaoaaie?oo ? aeyaeaiiy i?noey eiai
aeeth/aiiy oeyoii oioia?ao?/ii? ?a?no?aoe?? ii?ii?iaiiy. A
aeine?aeaeaiiyo aoei aeei?enoaii oae? ?aae?iioee?aee, ye 3I-oei?aeei,
3I-ae?oeei, 35S-noeueoao, ye? aaiaeeee oaa?eiai aioo??oiueii/a?aaeiii
i?ney cae?i/aiiy aenia?eiaioo ca 1, 24, 48, 120 aiaeei (aeey
3I-oei?aeeio) oa 1, 24, 192 aiaeeie (aeey 3I-ae?oeeio ? 35S-noeueoaoo)
aei caai?o iaoa??aeo.

I?ae na?oeiaei i?e?ineiiii (?ia?n?eiee ia’?eoea, ca?eueoaiiy IAo100,
IEo12,5) ia a?noiaaoia?aoao aecia/aee ?iaeaen i?/aiiy yaea? i?e iaeii-
? aaaaoi?aciaiio aaaaeaii? ?aae?iioee?aea. Oaeiae aecia/aee
?ioaineai?noue ?aae?iaeoeaii? i?oee ca eiioeaio?aoe??th ca?ai n??aea
iaae yae?aie ee?oei o ??ci? oa?i?ie i?ney iaeii?aciaiai aaaaeaiiy
?cioiio.

Ia a?noiaaoia?aoao c 35S-noeueoaoii ? 3I-ae?oeeiii i?ae?aoiaoaaee
e?euee?noue ca?ai n??aea iaae inoaiaaiieie ee?oeiaie e iniiaiith
?a/iaeiith e?noee. I?ae?aooiie i?oee i?iaiaeeee ia aea?aaeaioieo ieiuao
a?noic??c?a o ciiao aeoeaiiai inoaiaaiaco.

Io?eiai? oeeo?ia? aeai? ia?iaeyee noaoenoe/ii iaoiaeaie aa??aoe?eii?
noaoenoeee. Ia/eneaiiy i?iaiaeeee ia eiii’thoa?? oeio “?AI-486” c
aeei?enoaiiyi niaoe?aeueieo i?ia?ai.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Aeai? inoaiiao???
na?ae/aoue i?i cao?eieo ?inoo ? oi?iiooai?aiiy aeiaaeo o?oa/anoeo e?noie
neaeaoa a oiiaao naeioeaai? ?ioieneeaoe??. Oae, oe?eia aeenoaeueiiai
ai?o?co noaaiiai? e?noee ciaioeeanue ia 14,3 % (? < 0,001), a oe?eia na?aaeeie ae?ao?co ia 19, 8 % (? < 0,001). Niinoa??aa?oueny caoaeaiiy ai?o?ca?iiai o?yua aeenoaeueiiai ai?o?co noaaiiai? e?noee ia 36,6 % (? < 0,001) o oaa?ei, ye? ciaoiaeeeenue a oiiaao naeioeaai? ?ioieneeaoe??. E?a? eiai ia??ai? ? iaae? i?ae ciiaie ? caeaaeaeaieie. Ao?a/a?oueny ciiaeueia aoaeiaa ai?o?ca?iiai o?yua, ca?eueoo?oueny e?euee?noue i?ii?aeii? ?a/iaeie. E?euee?noue ee?oei o cii? ?iaeeoa?aioiiai o?yua aeaui ciaioaia. Oe?eia oe??? ciie ciaioeeanue ia 14,8 % (p < 0,05) ii??aiyii c oaa?eiaie eiio?ieueii? a?oie. Ciia i?ie?oa?aoe?? aeenoaeueiiai ai?o?ca?iiai o?yua caoaeaia ia 21,9 % (? < 0,001). Ooo niinoa??aa?oueny neoi/aiiy ee?oei, ye? oi?iothoue eieiiee, a oiiae?ioeeoe iaaoaathoue eeeiiiiae?aii? oi?ie. I?noeyie oe? eieiiee oiiae?ioeeo?a ao?a/athoue naith aacia?a?ai?noue ? iiacaeiaaei?e iai?yiie ?icoaooaaiiy; aiie ? aee?eaeaieie ? /anoi ia?a?eaathoueny ae?eyieaie i?ii?aeii? ?a/iaeie. I?ae noiaa/eeaie (eieiieaie) oiiae?ioeeo?a i?iieeathoue o aeaeyae? oyae?a eieaaaiia? o?a?eee, ioi/ai? i?ii?aeiith ?a/iaeiith. Niinoa??aa?oueny i?eai?/aiiy i?oioe/ii? aeoeaiino? ee?oei ? a?aei?/aii eeoa iiiaeeiie? o?ao?e i?oic?a; e?euee?noue i?ie?oa?oth/eo ee?oei ciaioeeanue o na?aaeiueiio ia 45,48 % (? < 0,001). O oe?e cii? c’yaeythoueny iaa?oue ee?oeie oeio o?a?iaeano?a, ye? eaaeaoue o iaaeinoaoiuei noi?iiaaiiio o?a?eey?iiio iao?een?. A cii? aeao?i?oeaiiai o?yua a?aei?/a?oueny ii?ooaiiy noiai/anoiai ?ici?uaiiy oiiae?ioeeo?a ? ciaioaiiy ?o e?eueeino?. I?ioyaei?noue oe??? ciie ciaioeeanue ia 29,3 % (? < 0,05). Iaae? i?ae ciiaie caeaaeaeothoueny ? ciia aeao?i?oeaiiai o?yua iinooiiai aac ??ceeo a?aieoeue ia?aoiaeeoue o ciio aeano?oeoeaiiai o?yua, aea i?ioean aeeoa?aioe?thaaiiy caaiiaiiai o?yua a oeiiaeo e?noeiaeo aaeeao ??cei i?eai?/o?oueny. A cii? aeano?oeoe?? niinoa??aa?oueny ?ioaineaia ?oeioaaiiy oiiae?ioeeo?a, ?? oiaueia a?aeiia?aea? ae?aiao?o iaei??? /e aeae?eueeio ee?oei, a iaae? aeineoue /?oe?. Oey ciia aaciina?aaeiuei iaaeo? c iaoao?cii, ca?aeee a ia? i?iieeathoue eai?ey?e oa inoaiaaii? ee?oeie. Aiane?aeie eaeueoeeiaoe?? o?yuiaiai iao?eeno oiiae?ioeeoe ooo aeiooue. Oae? aeeaie? no?oeoo?i? ia?aoai?aiiy iiyniththoueny aenieith iaoaaie?/iith aeoeai?noth ?inoiai? ciie, aiane?aeie /iai oey ae?eyiea e?noee iaea?eueo ii?ooo?oueny i?e ae?? aeno?aiaeueiiai oaeoi?a. A cii? cai?uaiiy o?yua enoeith o?aieythoueny ii?iaeieie ?aci?aoe?? c inoaieeanoaie ia ia?eoa???. Aeaye? ii?iaeieie ceeaathoueny ii aeae?eueea a iaeio aaeeeo, ooai?thth/e iai?aaeeueii? oi?ie ia/a?e. Aeeaeia i?iieeiaiiy o?yuiaeo o?aaaeoe o e?noeiai-iiceiao ?a/iaeio ciaioo?oueny, a aoa/anoa ?a/iaeia nai?ie ae?inoaie o aeaeyae? aaei/ie iaioa caio?th?oueny a oeth ii?iaeieio. E?noeiai-iiceiaee eaiae caiiaiaiee aeiaoei e?noeiaei iiceii. E?noeia? aaeee oiie?, ?ic??ciai?, i?aeaaei/i? i?inoi?e ? u?eeie caiiaiai? aee?iaith ? i?aeiiaieieienoith niieo/iith oeaieiith. Inoaioeeoe ae??ai?o?, aeoyaiooi? oi?ie c a?ia?o?iiieie yae?aie, ia??aeei ?ici?uothoueny iiiaeeiiei. A?aecia/a?oueny ciaioaiiy e?eueeino? inoaiaeano?a, a aeiaaeeia o?aaaeoe ia?aeiii? niiia?ice ciaioeeanue ia 46,1 % (? < 0,05) o ii??aiyii? c aeiaaeie o?oa/anoeie e?noeaie eiio?ieueieo oaa?ei. Inoaiaeanoe ?ici?uothoueny ei?ioeeie eaioethaeeaie aai ?ic??ciaii. Niinoa??aa?oueny a?aenooi?noue inoai?aeii? ?a/iaeie a?ey ieo. Aoa/anoa ?a/iaeia caeia? aaeeeo ieiuo ca ?aooiie ciaioaiiy oiaueie eiiiaeoiiai oa?o. Aeano?oeoeai? ci?ie aeyaeythoueny ? a eiiiaeoi?e ?a/iaei?. Aiia i?noeoue oa? inoai?aeo ? a?aeiaaeiao?oueny a?ae i?aeaaei/ieo i?inoi??a iaeiei aai aeaiia ?yaeaie inoaiaeano?a, e?euee?noue yeeo o ia?aeii?e niiia?ic? ciaioeeanue ia 20,4% (p < 0,05). I?e ii?oiiao?e/iiio aea/aii? ia iicaeiaaei?o c??cao na?aaeeie ciie ae?ao?co aeiaaeo o?oa/anoeo e?noie caa?oa? ia naaa oaaao aeoeaia no?oeoo?ia ia?aaoaeiaa, yea i?ecaiaeeoue aei iinooiiaiai cai?uaiiy ia?aeiii? a?oaiaieieienoi? oeaieie eiiiaeoiith ieanoei/anoith ? ia?a?eaaiiyi e?i?e neeathaaiiy. A?aei?/a?oueny aaeueioaaiiy aiiiceoe?eiiai ?inoo. Aeeaiea ia?aaoaeiaa no?oeoo?e e?noee ?aa?aneaiiai oa?aeoa?o i?e naeioeaa?e ?ioieneeaoe?? iiynith?oueny aeenaaeainii a ?ioaineaiino? a?ineioaco iniiaieo eiiiiiaio?a e?noeiaiai iao?eeno. A iniiai?e ?a/iaei? aaaaoi i?o ?aci?aoe?? c aaeeeeie oaiieie ee?oeiaie ii ia?eoa??? ? iaeiie/aiiyi iae?ioe/ieo ian. I?aia?aoe iiacaeiaaei?o c??c?a na?aaeeie ae?ao?co i?noyoue ae?eyiee c ??ciith ?ioaineai?noth caaa?aeaiiy, ui iaaea? ?i aeaeyaeo iica?ee. Oe? iica?/i? ae?eyiee ci?iththoue iaeia iaeio ? e?noeiaa oeaieia aeaeyaea? “ieyienoith”. A eiiiaeoi?e ?a/iaei? i?iyaeythoueny iciaee inoaiii?ico, yeee noi?iaiaeaeo?oueny eaeoia?iei ?icniieooaaiiyi e?noeiaeo aaeie, ciaioaiiyi ieiu? eiiiaeoii? ?a/iaeie. E?noei?oei?ai? i?ioeane ia?aaaaeathoue iaae e?noeiooai?thth/eie. Ii oiaeo /eneaiieo iica?/ieo nioa a?aei?/aii ae?eyiee ao?io?? e?noeiai? oeaieie. ?aci?aoeaia ae?yeuei?noue inoaieeano?a i?ecaiaeeoue aei ca?eueoaiiy e?noeiai-iiceiaiai eaiaeo. E?noeiaa oeaieia i?noeoue iaioa caaiiaii? i?ii?aeii? ?a/iaeie. Ana oea na?ae/eoue i?i cia/io ii?oi-ooieoe?iiaeueio ia?aaoaeiao. A?aei?/a?oueny caoaeaiiy ciai?oiueiai oa?o ia??inoo ia 17,1 % (? < 0,05), a iaae? i?ae ciai?oi?i ? aioo??oi?i (inoaiiiei) oa?ii a?ae??ciythoueny ia??ai?noth. ? iiiaeeiie? o?a?iaeanoe e aeanoe/i? aieieia. Inoaiaaii? ee?oeie iaeiaeoeai? ? neaai i?ie?oa?othoue. Na?aae ieo aeineoue ??aeei o?aieythoueny o?ao?e i?oic?a. Ae?eyiee, ye? ?ioaineaii caaa?aeai?, /a?aothoueny c ae?aeeie o oeo i?noeyo, aea i?ioiaeyoue aeano?oeoeai? ci?ie. Iiaiooai?aia e?noeiaa oeaieia ? i?ici?ith ? iooeith, ui i?ecaiaeeoue aei ?icaeoeo yaeu inoaiii?ico. Caaaeueia oe?eia aioo??oiueiai (inoaiiiiai) oa?o ciie ae?ao?co ciaioeeanue ia 7,2 % (? > 0,05); a iaoao?c? oe?eia oeueiai oa?o
ciaioeeanue ia 14,2 % (? < 0,05). A aiaeinoaeuei?e e?nooe? /anoi o?aieythoueny iiey ?aci?aoe?? aai inoai?aei? /e e?noeia? ia?iuaiiy. E?euee?noue inoaiaeano?a ye a aiaeino?, oae ? a ia??ino? ae?ao?co, ia oiiaio iaeeieoeth ieiu? a?noic??co, ciaioeeanue a?aeiia?aeii a na?aaeiueiio ia 29,3 % ? 24,4 % (? < 0,05). Oea na?ae/eoue i?i oa, ui a cii? aiaeinoo ae?ao?co a?aeaoaa?oueny oiia?eueiaiiy ?inoiaeo i?ioean?a. O noaeiaiaiio o?yu? i?aeaeine?aeieo oaa?ei oaeiae a?aei?/aii ?noioi? a?aei?iiino? ii??aiyii c eiio?ieueieie. A iniiaiiio a?i i?aaenoaaeaiee aeaci?aai?ciaaieie o?yuiaeie noiai/eeaie. Iaae? i?ae ciiaie noaeiaiaiai o?yua ? ia/?oeeie ? caeaaeaeaieie. Ia?aaaaeathoue ooieoe?iiaeueii aeoeai? ee?oeie c aaeeeei aacio?eueiei yae?ii; a?aei?/aii a?ia?ieac?th oiiae?ioeeo?a a ie?aieo ae?eyieao noaeiaiaiai o?yua. Iaea?eueo oeeo aeano?oeoeaieo ci?i cacia? na?aaei?e oa?, yeee i?aaenoaaeaiee o?yuiaeie ee?oeiaie (oiiae?ioeeoaie). A ieo niinoa??aa?oueny i?eai?/aiiy a?ineioaoe/ii? ? ?ai?iaeoeoeaii? aeoeaiino?. Cia/ii aoae/eie noathoue iiaa?oiaa? ciie noaeiaiaiai o?yua (ieneo?eueia, ia?ao?aeia ? ciia ?ciaaiieo a?oi), ye? ? a?eueo iieiaeeie. A cii? eaeueoeeiaoe?? ne?ae a?aei?oeoe ?ic?eae ? o?aaiaioaoe?th aacio?eueii? e?i??. Oea aeaco? ia oa, ui a oiiaao naeioeaai? ?ioieneeaoe?? ii?ooo?oueny aeenaaeain o aca?iiae?? o?yua ? e?noee; o?yuiaa oeaieia a oeeo oiiaao iioeiaeaeo?oueny, iae?ioeco?oueny ? eaeueoeeio?oueny . Na?aaeiy oe?eia noaeiaiaiai o?yua ciaioeeanue ia 22,5 % (? < 0,001). A oiiaao uiaeaiiiai o?eaaeiai (3,5 i?nyoe?a) iaaeoiaeaeaiiy a i?aai?ci naeioeth aeicith 10 ia/ea iane iaeiie/aiiy eiai a?aeaoaa?oueny a iniiaiiio a e?noeia?e oeaiei?. Iaea?eueo ae?aaeaieie ? i?ioeane ia?aaoaeiae a iaoao?cao, aea ia?aaaaeii iaeiie/o?oueny naeiaoeue. A?aei?/aii ?ic??aeaeaiiy ? ciaioaiiy e?eueeino? e?noeiaeo o?aaaeoe c ?icoe?aiiyi e?noeiai-iiceiaeo i?inoi??a, i?i ui iiaeia noaeeoe c? cieaeaiiy ieoiiiai ia’?io e?noeiaeo o?aaaeoe a iaoao?cao o i?aeaeine?aeii? a?oie oaa?ei. I?e iaaeoiaeaeaii? a i?aai?ci oaa?ei aoeaoaoo naeioeth niinoa??aa?oueny i?aeneeaiiy, ii??aiyii c eiio?ieai, ?aci?aoeaieo i?ioean?a a ei?oeeaeuei?e e?nooe?. Oeae i?ioean noi?iaiaeaeo?oueny ?ic?inoaiiyi o?a?icii? oeaieie ? a?aeaoaa?oueny ca o/ano? inoaieeano?a. Ia ii/aoeiaeo noaae?yo ?icai?oaiiy i?ioean?a ?aci?aoe?? inoaieeanoe eiioeaio?othoueny iiaeeco noaeei a?ey naii? iiaa?oi? e?noee, aeath/e ii/aoie e?noeiaei eaeoiai, eoaee iio?i caio?ththoueny noaeeie c o?a?iaeanoe/ieie ee?oeiaie, ye? ?o noi?iaiaeaeothoue, cai?uoth/e e?noeo. Oe? ia?aaoaeiae coiiaeai? cia/iith i??ith ci?iaie a ee?oeiao cii inoaiaaiaco ?ioaineaiino? i?ioean?a niaoeeo?/iiai iaoaaie?cio. I?e oeueo?ai?e?ineii?/iiio aea/aii? aeenoaeueieo ai?o?ca?ieo o?yu?a noaaiiaeo e?noie o cii? i?ie?oa?aoe?? a?aeaoaa?oueny /anoeiaa aeano?oeoe?y oiiae?ioeeo?a. Aiie eaaeaoue o iiaaii noi?iiaai?e i?aeee?oeii?e ?a/iaei? ? i?noyoue o nia? eieaaaiia? aieieia aac ae?aaeaii? iinioaiaaiino?. Niinoa??aa?oueny aaaaoi oaiieo aeaeo?iiii-u?eueieo oiiae?ioeeo?a, ye? oa?aeoa?ecothoueny ciaioaieie ?ici??aie ? iacia/iith e?euee?noth ae?ino?a. Ie?ai? oiiae?ioeeoe ca?eueoai? a ia’?i? ? i?noyoue i?eiioe/i? cii?oeoaao? yae?a c yaea?oeyie iaaaeeeeo ?ici???a. A yae?ao i?inoaaeo?oueny i?noeaaa ?icoe?aiiy ia?eioeeaa?ieo oeenoa?i ? eiiaeainaoe?y ia?eoa??eiiai aaoa?io?iiaoeio acaeiaae aioo??oiuei? iaia?aie yae?a, ca ?aooiie yeiai aiie iaaoaathoue oaiiiai eieuei?o. ssae?a ie?oaei? oi?ie c iaaaeeeeie ia?aoyaeeaie, o ?o ea??ieai? neaai ?ic??ciythoueny yaea?i? ii?e. Oeeoiieacia oaeeo o?yuiaeo ee?oei ia? ciaioaio u?euei?noue i?aaiae ? aaeee? aacno?oeoo?i? ciie. A?aei?/aii ?ic/eiaiiy e?eno i?oioiiae??e ? i?ina?oeaiiy ?o iao?eeno. Oeenoa?ie a?aioey?ii? aiaeiieaciaoe/ii? n?oee neaai ?icaeiai? ? o?aaiaioiaai?. Aiie i?noyoue iaaaeeeo e?euee?noue iiiaeeiieeo ?eainii oa iie?nii. Aeaiaioe ieanoei/anoiai eiiieaeno iaa?yee?. A?ey ieo aeyaeaii e?i?aei? aeeth/aiiy oa no?oeoo?e oeio e?cinii. Ne?ae a?aei?oeoe ? oa, ui a iaaeao iaei??? ?ciaaiii? a?oie oiiae?ioeeoe a?ae??ciythoueny ca oa?aeoa?ii ia?aoai?aiue: iaei? c ieo ciaioothoueny a ia’?i?, iathoue aeaeo?iiii-u?eueio oeeoiieacio, a ye?e aeae?eythoue ciie i?ina?oeaiiy ? aaeoie?; ?io? - iaa?yee?, iioe/ii-i?ici??, i?noyoue e?i?aei? aeeth/aiiy ? oiaoeiiiae?ai? aacno?oeoo?i? ooai?aiiy, iiiaeeiie? c?oeiiaai? i?aaiaee. Ia??aeei aeiaeiea oaeeo ee?oei c’yaeythoueny i?ina?oeai? ciie c ae??aiica?ienoei ai?noii aaceieaaaiiaeo i?e?io?a?ee. Aeua iienaia ea?oeia, yeo io?eiaii i?e noai?e?ineii?/iiio aeine?aeaeaii?, na?ae/eoue i?i cieaeaiiy aeoeaiino? oiiae?ioeeo?a. Oaeei /eiii, ca aeaieie inoai- ? ii?oiiao???, a oaeiae aeaeo?iiii? i?e?ineii?? naeioeaaa ?ioieneeaoe?y iii?oii aieeaa? ia no?oeoo?o oa oi?iiooai?aiiy aeiaaeo o?oa/anoeo e?noie neaeaoa. A ciiao ?inoo ? ia?aaoaeiae e?noie niinoa??aathoueny niia?eueiai? i?ioeane e?noeiooai?aiiy, ii?yae c oeei a ae?eyioe? ae?ao?c?a a?aecia/athoueny iciaee i?aeneeaiiy i?ioean?a ?aci?aoe?? oa ao?io??. A eiiiaeoi?e ?a/iaei?, ie??i ooieoe?iiaeueii? ia?aaoaeiae, o?aieythoueny e inoai?aei? ae?eyiee, ye? na?ae/aoue i?i iiyao iciae iaoieia?/iiai ia?aoai?aiiy e?noeiai? oeaieie. I?i cieaeaiiy oaii?a ?inoiaeo ? inoaiieanoe/ieo i?ioean?a o e?nooe? i?e naeioeaa?e ?ioieneeaoe?? na?ae/aoue ? aeai? ?aae?iaaoia?ao?? c3I-oei?aeeiii, 3I-ae?oeeiii ? 35S-noeueoaoii. I?e iaeii?aciaiio i?/aii? AeIE-neioacoth/eo ee?oei oeyoii aaaaeaiiy 3I-oei?aeeio aeyaeaii ciaioaiiy e?eueeino? AeIE-neioacoth/eo ee?oei o ciiao aeoeaiiai inoaiaaiaco, ianaiia?aae o iiioeyoe?? ia?eaaneoey?ieo ee?oei, ye? i?noyoue inoaiaaii? ee?oeie-iiia?aaeieee. A oeeo ae?eyieao e?noee aeyaeaii iaeneiaeuei? cia/aiiy ?iaeaeno i?/aieo yaea? (?Iss, %) ee?oei i?e aeniiceoe?? 48 aiaeei i?ney aaaaeaiiy 3I-oei?aeeio o oaa?ei eiio?ieueii? (??? na??y) ? aenia?eiaioaeueii? (?V na??y) a?oi. Anoaiiaeaii oaeiae, ui iiioeyoe?y inoaiaeano?a a ciiao inoaiaaiaco iiiiaith?oueny ca ?aooiie i?ie?oa?aoe?? ? aeeoa?aioe?thaaiiy iaeiaeeoa?aioe?eiaaieo ia?eaaneoey?ieo ee?oei (/a?ac neaae?th i?ainoaiaeano?a). Aeeoa?aioe?thaaiiy ee?oei i?ioiaeeoue /a?ac ?yae (1-3) ae?eaiue ? noi?iaiaeaeo?oueny ciaioaiiyi i?ie?oa?aoeaii? aeoeaiino? ee?oei. A aeao?i?oeai?e e?nooe? ?aaoeyoe?y ?ioaineaiino? ?inoiaeo i?ioean?a caaacia/o?oueny e?euee?nieie ci?iaie i?ie?oa?aoeaiiai ioeo i?ainoaiaeano?a, ye? aoiaeyoue a neeaae aiaeinoo ? ia??inoo, a oaeiae noaeeiieo eaiae?a. Na?aaeiy ?ioaineai?noue i?/aiiy ee?oei /a?ac 1 aiaeeio i?ney aaaaeaiiy 3I-oei?aeeio ia? iaeneiaeueia cia/aiiy 17 ca?ai n??aea. Aei 120 aiaeeie aenia?eiaioo oeae iieaciee cieaeo?oueny iaeaea a 2 ?ace ? a iiioeyoe?? AeIE-neioacoth/eo ee?oei ca?eueoo?oueny e?euee?noue ee?oei c i?oeith 4-7 ca?ai n??aea. Oea na?ae/eoue i?i oa, ui a oiiaao naeioeaai? ?ioieneeaoe?? a?aeaoaa?oueny ciaioaiiy ?ioaineaiino? i?/aiiy ee?oei ?, ye iane?aeie, i?eai?/aiiy i?ioean?a i?ie?oa?aoe?? ? aeeoa?aioe?thaaiiy inoaiaaiieo ee?oei. I?e aaaaoi?aciaiio aaaaeaii? 3I-oei?aeeio i?ie?oa?aoeaiee ioe a cii? aioiiae?aeueiiai i?ioeano a noaaiiaeo e?noeao 6-i?ny/ieo uo??a i?e io?othaaii? aoeaoaoii naeioeth aeicith 10 ia/ea iaeneiaeueieo cia/aiue aeinyaa? aei 72 aiaeeie aenia?eiaioo ? noaiiaeoue 20 % a eiio?ie? ? 18 % a aeine?ae?, ? < 0,05. Cieaeaiiy ?ioaineaiino? i?ioean?a ?inoo e?noee a?aeaoaa?oueny, cie?aia, a ?acoeueoao? cieaeaiiy ioeo AeIE-neioacoth/eo inoaiaaiieo ee?oei-iiia?aaeiee?a. Anoaiiaeaii, ui 3I-ae?oeei anei?eth?oueny inoaiaaiieie ee?oeiaie ia??inoo e aiaeinoo c ??ciith ?ioaineai?noth o oaa?ei i?aeaeine?aeii? a?oie, yea io?eioaaea uiaeaiii i?ioyaii 105 aei?a aoeaoao naeioeth aeicith 10 ia/ea, ? eiio?ieueii? a?oie. A?eueo iecueea, ii??aiyii c eiio?ieai, aeeth/aiiy 3I-ae?oeeio a inoaiaaii? ee?oeie i?aeaeine?aeieo oaa?ei na?ae/eoue i?i cieaeaiiy a oiiaao naeioeaai? ?ioieneeaoe?? ?ioaineaiino? i?ioean?a a?ineioaco eieaaaiiaeo a?ee?a. I?e/iio ?ioaineai?noue aeeth/aiiy 3I-ae?oeeio a inoaiaaii? ee?oeie aiaeinoo a iaoao?c? ye o eiio?ie?, oae ? a aeine?ae? aeua, i?ae o ia??ino? ae?ao?ca?ii? ciie, ? na?ae/aoue i?i oa, ui a aiaeino? i?ioeane a?ineioaco eieaaaiiaeo a?ee?a i?ioiaeyoue a?eueo ?ioaineaii, i?ae o ia??ino?. Ii??aiyeueiee aiae?c aeeiai?ee i?oee 3I-ae?oeeio a ee?oeiao ? i?aeee?oeiiiio iao?een? aiaeinoo ? ia??inoo /a?ac 0,5, 24 ? 192 aiaeeie iieacaa, ui anei?eueiaaiee ee?oeiaie 3I-ae?oeei o eiio?ieueieo oaa?ei aeaiaeeoueny ? aeeth/a?oueny a e?noeiaee iao?een oaeaeoa i?ae o oaa?ei, ye? io?eioaaee naeiaoeue. Oiaoi naeioeaaa ?ioieneeaoe?y a?aeia?aaea?oueny ? ia ?ioaineaiino? nae?aoe?? oa iaoaaie?cio eieaaaiiaeo a?ee?a. O aeine?aeao c aeei?enoaiiyi 3I-ae?oeeio o oiiae?ioeeoao a?aei?/aii i?eai?/aiiy a?ineioaco eieaaaiiaeo a?ee?a. Aaaaea?oueny, ui i?ae ae??th naeioeth a i?aai?ci? a?aeaoaa?oueny aeaiaoo?aoe?y oeaieiieo a?ee?a, ii?ooaiiy aani?aoeaieo aeanoeainoae a?eeiaeo iieaeoe (Iaaeoaa I.I., 1991; AEeoi?eia A.ss., 1998). Ciaioaiiy ?ioaineaiino? a?ineioaco eieaaaiiaeo a?ee?a a inoaiaaiieo ee?oeiao i?e naeioeaa?e ?ioieneeaoe?? a?aeaoaa?oueny ?acii c i?aeneeaiiyi anei?eyoe?? ee?oeiaie 35S-noeueoaoo, ui a?aeia?aaea? ?ioaineo?eaoe?th a?ineioaco noeueoaoiaaieo ae?eicai?iiae?eai?a, ye? aoiaeyoue aei neeaaeo i?aai?/iiai iao?eeno e?noee. Oae, /a?ac 1 aiaeeio i?ney aaaaeaiiy 35S-noeueoaoo i?oea aeyaey?oueny a iniiaiiio iaae inoaiaaiieie ee?oeiaie a o?aaaeoey?iiio aiaeino?. Iaeiae ia 192-o aiaeeio aeine?aeo i?oea ?aae?iioee?aea iaeaea iiai?noth aeaiaeeoueny a e?noeiaee iao?een ? aeyaey?oueny o aeaeyae? oae caaii? “nioae i?/aiiy”, a iaae inoaiaaiieie ee?oeiaie niinoa??aa?oueny aeinoia??ia ciaioaiiy oeueiai iieacieea. Oea aeaco? ia oa, ui ?ioieneeaoe?y i?aai?cio aoeaoaoii naeioeth aaaea aei ii?ooaiiy i?ioean?a ?o neioaco oa iaoaaie?cio. Aeenaaeain a ?ioaineaiino? a?ineioaco inoaiaaiieie ee?oeiaie iniiaieo eiiiiiaio?a e?noeiaiai iao?eeno coiiaeth? ia?aaoaeiao no?oeoo?e e?noee inoaiii?ioe/iiai oa?aeoa?o. Oaeei /eiii, naeiaoeue, aoaeo/e inoaio?iiiei aeaiaioii, aeeeeea? ae?aaeaiee inoaioiene/iee aoaeo. Ia?o ca ana, naeioeaaa ?ioieneeaoe?y aaaea aei i?eai?/aiiy i?ioean?a i?ie?oa?aoe?? ? aeeoa?aioe?thaaiiy inoaiaaiieo ee?oei oa ii?ooaiiy a ieo neioaco i?aai?/ieo eiiiiiaio?a, cie?aia eieaaaiiaeo a?ee?a ? ae?eicai?iiae?eai?a. Oaeiae i?e ae?? naeioeth niinoa??aa?oueny ciaioaiiy ieoiiiai ia’?io e?noeiaeo o?aaaeoe ? oiaueie ai?o?ca?iiai o?yua; o ae?ao?c? a?aeaoaa?oueny ?icoe?aiiy e?noeiai-iiceiaeo eaiae?a e?noee, a naia e?noeiaa oeaieia noa? a?eueo aeai?ia?ae?ciaaiith. A?aeaoaa?oueny ooai?aiiy ionoio, u?eei. Oe? ci?ie a?aeia?aaeathoue ?icaeoie inoaiii?ioe/ieo i?ioean?a o e?noeia?e oeaiei?. Iaea?eueo aiie ae?aaeai? a ciiao iaoao?co, aea aeoeaii i?ioiaeyoue i?ioeane ?inoo ? oi?iiooai?aiiy e?noie neaeaoa. A cii? na?aaeeie ae?ao?co cia/ieo ia?aaoaeia cacia? aiaeinoaeueiee oa?. I?iaaaeaia aeine?aeaeaiiy aeaei ciiao aeynieoe iniaeeaino? no?oeoo?ii-ooieoe?iiaeueieo ia?aoai?aiue aeiaaeo o?oa/anoeo e?noie neaeaoa a oiiaao naeioeaai? ?ioieneeaoe??. AENIIAEE 1. ?ioieneeaoe?y i?aai?cio aoeaoaoii naeioeth i?ioyaii 3,5 i?nyoe?a aeicith 10 ia/ea iane o?ea aeeeeea? aeano?oeoeai? ci?ie a iaoaai?o?ca?i?e ieanoeioe? ?inoo aeiaaeo o?oa/anoeo e?noie, ye? i?iyaeythoueny o ii?ooaii? ciiaeueii? no?oeoo?e, aoaeiae oeaieiiiai iao?eeno, oeueo?ano?oeoo?e o?yuiaeo oa inoaiaaiieo ee?oei, a oaeiae i?eai?/aiiy i?ioean?a i?ie?oa?aoe??, aeeoa?aioe?thaaiiy oa neioaoe/ii? aeoeaiino? inoaiaaiieo ee?oei. Ana oea aaaea aei cao?eiee i?ioean?a ?inoo ? oi?iiooai?aiiy, a a e?ioeaaiio ?acoeueoao? - aei ?icaeoeo iaoieia?/ieo ci?i o aeiaaeo o?oa/anoeo e?noeao e?ioe?aie. 2. Iaaaoeai? ci?ie, ye? aeeeeeai? ?ioieneeaoe??th niieoeaie naeioeth, iioe?ai? ? a cii? ae?ao?ca. Oa? ia??inoo noa? oiioei (ii??aiyii c eiio?ieai); caoaeo?oueny ciia inoaii?a a inoaiiiiio oa??; a?aeaoaa?oueny aeai?ia?ae?caoe?y e?noeiai? oeaieie ? ?icoe?aiiy e?noeiai-iiceiaiai eaiaeo ca ?aooiie ei?oeeaeueiiai ? aiaeinoaeueiiai oa??a e?noee. Ana oea na?ae/eoue i?i ?icaeoie inoaiii?ioe/ieo i?ioean?a a e?noeia?e oeaiei? aeiaaeo o?oa/anoeo e?noie. 3. A oiiaao naeioeaai? ?ioieneeaoe?? i?ie?oa?aoeaia aeoeai?noue inoaiaaiieo ee?oei i?eai?/aia. A?aeaoaa?oueny ciaioaiiy ?iaeaeno i?/aiiy, e?eueeino? AeIE-neioacoth/eo ee?oei a ciiao aeoeaiiai inoaiaaiaco. Iaeneiaeueiiai cia/aiiy ?ioaineai?noue i?/aiiy ee?oei aeinyaa? /a?ac 1 aiaeeio i?ney aaaaeaiiy 3I-oei?aeeio, a /a?ac 120 aiaeei aeine?aeo oeae iieaciee cieaeo?oueny aaea?/?. 4. I?e naeioeaa?e ?ioieneeaoe?? a?aei?/aii iecueea aeeth/aiiy ?aae?iioee?aea 3I-ae?oeeio a inoaiaaii? ee?oeie aiaeinoo ? ia??inoo. A?aeaoaa?oueny cieaeaiiy i?ioean?a ?o neioaco, ui a?aeia?aaea?oueny ia ?ioaineaiino? nae?aoe?? inoaiaaiieo ee?oei oa iaoaaie?ci? eieaaaiiaeo a?ee?a. 5. Aeine?aeaeaiiy ?ioaineaiino? a?ineioaco noeueoaoiaaieo ae?eicai?iiae?eai?a oa aeeiai?ee ia?ai?uaiiy ?o ?c inoaiaaiieo ee?oei a e?noeiaee iao?een na?ae/aoue, ui ?ioieneeaoe?y i?aai?cio aoeaoaoii naeioeth aaaea aei ii?ooaiiy i?ioean?a ?o neioaco oa iaoaaie?cio. 6. Anoaiiaeaii, ui iaea?eueo /ooeea? oa iaeneiaeueii ?aiei? ooieoe?iiaeuei? no?oeoo?e e?noie neaeaoa ia naeioeaao ?ioieneeaoe?th - ai?o?ca?iee o?yu oa ia??inoaeueia ciia ae?ao?ca. I?AEOE*I? ?AEIIAIAeAOe?? 1. Io?eiai? ?acoeueoaoe aeiiiaiththoue oai?aoe/i? aniaeoe i?iaeaie ooieoe?iiaeueii? ii?oieia??. Aeai? i?i iniaeeaino? aoaeiae, ?inoo ? oi?iiooai?aiiy aeiaaeo o?oa/anoeo e?noie neaeaoa iiaeooue aooe aeei?enoai? a iaoeiaeo aeine?aeaeaiiyo iii?ii-?ooiaiai aia?aoo ? a iaa/aeueiiio i?ioean? i?e aea/aii? ieoaiue aieeao aeieia?/ieo oaeoi??a ia e?noeiaee neaeao. 2. I?iaaaeaia aeine?aeaeaiiy i?iynith? nooue no?oeoo?ii-ooieoe?iiaeueieo ci?i, ye? a?aeaoaathoueny o aeiaaeo o?oa/anoeo e?noeao neaeaoa i?e ?ioieneeaoe?? i?aai?cio nieyie naeioeth. 3. Iienai? ii?oi-ooieoe?iiaeuei? ci?ie iaa?oioiaothoue aeey ee?i?oeeno?a i?iaaaeaiiy e?eoaaeueii-i?io?eaeoe/ieo caoiae?a c iaoith caiia?aaiiy ?icaeoeo iaoieia?/ieo i?ioean?a o e?noeao neaeaoa i?ney naeioeaai? ?ioieneeaoe??, aai ae ?? oa?iaeieia?/ii? ei?aeoe?? i?e aeieeiaii?. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. Aeiaaaethe O.ss. Aieea naeioeth ia a?ineioac ae?eicai?iiae?eai?a a inoaiaaiieo ee?oeiao // Oe?. iaaee/iee aeueiaiao. – Eoaainuee, 1998. - ? 3. – N. 76-79. 2. ?iae?iiiaa I.A., Aeiaaaethe O.ss. I?ie?oa?aoe?y ? aeeoa?aioe?thaaiiy inoaiaaiieo ee?oei i?e o?eaaeiio iinooiaii? naeioeth a i?aai?ci // Iaoe. a?niee AAeO. A?ieia?y. Iaaeeoeeia. – 1998. - ?4. – N. 16-19. 3. Aeiaaaethe O.ss. Ci?ie a no?oeoo?? aeiaaeo o?oa/anoeo e?noie neaeaoo uo??a i?ae aieeaii aoeaoaoo naeioeth // Iaoe.a?niee AAeO. A?ieia?/i? iaoee. – 1999. -? 4. - N. 55-58. 4. Aeiaaaethe O.ss. Iniaeeaino? aoaeiae ? ?inoo aeiaaeo o?oa/anoeo e?noie neaeaoo uo??a i?ae aieeaii nieae naeioeth // Iaoe. a?niee Oaeai?iaenueeiai aea?ae.oi?aa?neoaoo: Na??y “Iaaeeoeeia”. – 1999. - ? 9. - N. 23-26. 5. Aeaye? aniaeoe inoaiaaiaco o?oa/anoeo e?noie neaeaoo a aenia?eiaio? i?ae aieeaii aeciaaiiiai aieeao aoeaoaoo naeioeth oa i?e o?ii?/iiio iaaeoiaeaeaii? ?aae?iioee?ae?a / Ieeaethe A.N., ?iae?iiiaa I.A., Aeiaaaethe O.ss., Ioce/aiei I.N., ?iiaiaiei I.A. // Aeooaeuei? ieoaiiy ii?oieia??. Iaoa??aee ?? Iaoe. eiia?ano AAAO Oe?a?ie. – Eoaainuee, 1998. – N. 199-200. 6. Ieeaethe A.N., ?iae?iiiaa I.A., Aeiaaaethe O.ss. A?ineioac ae?eicai?iiae?eai?a i?ae ae??th aoeaoaoo naeioeth // I?iaeaie a?eiai? o?c?ieia??: Iaoa??aee eiioa?aioe??. - Eooeuee, 1998. – N. 63-64. AIIOAOe?ss Aeiaaaethe O.ss. No?oeoo?ii-ooieoe?iiaeuei? ci?ie a aeiaaeo o?oa/anoeo e?noeao neaeaoo a?eeo uo??a i?e ae?? ia i?aai?ci naeioeaai? ?ioieneeaoe??. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 14.03.01 – ii?iaeueia aiaoii?y. - Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?iai? ?.ss. Ai?aa/aanueeiai. - Oa?iii?eue, 1999. Aeena?oaoe?th i?enay/aii aeine?aeaeaiith iniaeeainoae aoaeiae, ?inoo ? oi?iiooai?aiiy aeiaaeo o?oa/anoeo e?noie neaeaoa a?eeo uo??a a oiiaao naeioeaai? ?ioieneeaoe??. Anoaiiaeaii, ui ?ioieneeaoe?y naeioeai iaaaoeaii aieeaa? ia i?aai?ci ethaeeie. Iniaeeao /ooeea?noue ia iayai?noue inoaio?iiiiai naeioeth ia? neaeao, yeee ?inoa. Naia a iueiio niinoa??aathoueny iaea?eueo aeoeai? i?ioeane ?iciiiaeaiiy ? aeeoa?aioe?thaaiiy ee?oei, ui caaacia/othoue iaoaaie?/io ? no?oeoo?io iniiao aeey ?inoo o?yua ? oi?ioaaiiy e?noee. I?e ae?? nieae naeioeth a?aeaoaa?oueny oiia?eueiaiiy ?inoo ? oi?iiooai?aiiy e?noie neaeaoa, i?eai?/aiiy i?ioean?a i?ie?oa?aoe?? ? aeeoa?aioe?thaaiiy inoaiaaiieo ee?oei, a oaeiae a?ineioaoe/ieo i?ioean?a, ui i?ioiaeyoue o oeeo ee?oeiao. Ie??i oiai, naeioeaaa ?ioieneeaoe?y aeeeeea? no?oeoo?i? ci?ie. Eeth/ia? neiaa: aeiaa? o?oa/ano? e?noee, inoaiaaii? oa o?yuia? ee?oeie, ??no, oi?iiooai?aiiy, iaoaai?o?ca?iee oa noaeiaiaee o?yu?, ?aae?iaaoia?ao?y, i?ie?oa?aoe?y, naeioeaaa ?ioieneeaoe?y. AIIIOAOeEss Aeiaaaethe O.ss. No?oeoo?ii-ooieoeeiiaeueiua eciaiaiey a aeeeiiuo o?oa/anouo einoyo neaeaoa aaeuo e?un i?e aeaenoaee ia i?aaieci naeioeiaie eioieneeaoeee. - ?oeiienue. Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 14.03.01 – ii?iaeueiay aiaoiiey. - Oa?iiiieueneay ainoaea?noaaiiay iaaeeoeeineay aeaaeaiey eiaie E.ss. Ai?aa/aaneiai. - Oa?iiiieue, 1999. Aeenna?oaoeey iinayuaia eco/aieth iniaaiiinoae no?iaiey, ?inoa e oi?iiia?aciaaiey aeeeiiuo o?oa/aouo einoae neaeaoa aaeuo e?un a oneiaeyo naeioeiaie eioieneeaoeee. Iaoa?eaeii aeey enneaaeiaaiey iineoaeeee aeeeiiua o?oa/aoua (aaae?aiiua) einoe aaeuo e?un-naioeia, aic?anoii 6 ianyoeaa. Onoaiiaeaii, /oi eioieneeaoeey naeioeii iaaeaaii?eyoii aeeyao ia i?aaieci /aeiaaea. Iniaie /oanoaeoaeueiinoth ia i?enoonoaea inoaio?iiiiai naeioea iaeaaeaao ?anoouee neaeao, a eioi?ii iaeneiaeueii aeoeaiu i?ioeannu ?aciiiaeaiey e aeeooa?aioeeaoeee eeaoie, iaania/eaathueo iaoaaiee/aneia e no?oeoo?iia iniiaaiea aeey ?inoa o?yua e oi?iiia?aciaaiey einoe. O aeeaioiuo, eioi?ua iaoiaeeeenue a oneiaeyo naeioeiaie eioieneeaoeee, ioia/aaony noaeaiea oe?eiu yieoeca?iiai e noaeiaiaiai o?yuae. A ciia i?ieeoa?aoeee eieiiee oiiae?ioeeoia oa?ytho naith iai?a?uaiinoue e i?iaeieueiia iai?aaeaiea. Iaaethaeaaony oaiaoaiea ieoioe/aneie aeoeaiinoe eeaoie, a eiee/anoai i?ieeoa?othueo eeaoie oiaiueoaii. A ciia ia?ae/iiai inoaiaaiaca ano?a/athony iieinoe ?aci?aoeee. Einoiua aaeee oiieea, iaaeaaei/iua i?inoi?u e uaee caiieiaiu aee?iaie e iaaeiiaieieienoie oeaiueth. A aeeaoeca ioia/aaony noaeaiea ia?oaeiiai e aioo?aiiaai neiaa ia?einoa; einoii-iicaiaua eaiaeu ?anoe?ythony. Inoaiaaiiua eeaoee iaeiaeoeaiu e neaai i?ieeoa?otho. Iiaiia?aciaaiiay einoiay oeaiue noaiiaeony i?ic?a/iie e ?uoeie, /oi aaaeao e ?acaeoeth inoaiii?ioe/aneeo i?ioeannia. I?e oeueo?aiee?ineiie/aneii enneaaeiaaiee aeenoaeueiuo yieoeca?iuo o?yuae aaae?aiiuo einoae a ciia i?ieeoa?aoeee i?ineaaeeaaaony aeano?oeoeey oiiae?ioeeoia, eioi?ua eaaeao a neaai noi?ie?iaaiiii iaaeeeaoi/iii aauanoaa. Iaaethaeaaony oiaiueoaiea eo ?acia?ia n iacia/eoaeueiui eiee/anoaii au?inoia. Ioia/aaony ?anoai?aiea e?eno ieoioiiae?ee; oeenoa?iu a?aioey?iie yiaeiieaciaoe/aneie naoee neaai ?acaeou, yeaiaiou ieanoei/anoiai eiiieaena - iaaoooea. Naeioeiaay eioieneeaoeey ia?ooaao a inoaiaaiiuo eeaoeao i?ioeannu aeineioaca i?aaie/aneeo eiiiiiaioia (eieeaaaiiauo aaeeia e noeueoaoe?iaaiuo aeeeicaieiiaeeeaiia). Onoaiiaeaii, /oi 3I-aeeoeei anneieee?oaony inoaiaaiiuie eeaoeaie ia?einoa e yiaeinoa n ?aciie eioaineaiinoth o aeeaioiuo iiaeiiuoiie e eiio?ieueiie a?oii. Aieaa ieceia aeeth/aiea ?aaeeiioeeeaea a eeaoee iiaeiiuoiuo aeeaioiuo naeaeaoaeuenoaoao i nieaeaiee a oneiaeyo naeioeiaie eioieneeaoeee eioaineaiinoe i?ioeannia neioaca eieeaaaiiauo aaeeia. A ciia iaoaoeca eioaineaiinoue aeeth/aiey ecioiia auoa, /ai a ia?einoa aeeaoeca?iie ciiu, /oi naeaeaoaeuenoaoao i aieaa eioaineaiii aeineioaca eieeaaaiiauo aaeeia a iaoaoeca. Oiaiueoaiea eioaineaiinoe aeineioaca eieeaaaiiauo aaeeia a inoaiaaiiuo eeaoeao i?e naeioeiaie eioieneeaoeee i?ienoiaeeo aianoa n oneeaieai anneieeyoeee eeaoeaie 35S-noeueoaoa, /oi io?aaeaao eioaineoeeaoeeth aeineioaca noeueoaoe?iaaiuo aeeeicaieiiaeeeaiia. Iaoea ?aaeeiioeeeaea ii/oe auaiaeeony a einoiue iao?een e i?iyaeyaony “iieinaie ia/aiey”. Auoaoiiiyiooua eciaiaiey naeaeaoaeuenoaotho i inoaio?iiiinoe naeioea n au?aaeaiiui inoaioiene/aneei yooaeoii. Naeioeiaay eioieneeaoeey oaiaoaao i?ioeannu i?ieeoa?aoeee e aeeooa?aioee?iaaiey inoaiaaiiuo eeaoie, a oaeaea ia?ooaao neioac i?aaie/aneeo eiiiiiaioia (eieeaaaiiauo aaeeia e aeeeicaieiiaeeeaiia). Caiaaeeaiea yoeo i?ioeannia niinianoaoao eioaineaiiio ioeiaeaieth naeioea a einoiie oeaie. Naeioeiaiy eioieneeaoeey aaaeao e e no?oeoo?iui eciaiaieyi. Iie iaeaieaa au?aaeaiu a iaoaoecao - ciiao iaeneiaeueii aeoeaiuo i?ioeannia ?inoa e oi?iiia?aciaaiey. Eeth/aaua neiaa: aeeeiiua o?oa/aoua einoe, inoaiaaiiua e o?yuaaua eeaoee, ?ino, oi?iiia?aciaaiea, iaoayieoeca?iue e nonoaaiie o?yue, ?aaeeiaaoia?aoey, i?ieeoa?aoeey, naeioeiaay eioieneeaoeey. SUMMARY Dovgalyuk T.Y. Structurional and functional changes in long tubular bone of white rat’s skeleton with the influence lead’s intoxication on organism. - Manuscript. Thesis for scientific degree of Candidate of Biological Sciences. Speciality: 14.03.01. – Normal Anatomy. - Ternopil State Medical Academy named after I.Y. Gorbachevsky. - Ternopil, 1999. The thesis is dedicated to the studies of pecularities of structure, growth and formation of long tubular bones of white rat’s skeleton in condition of lead’s intoxication. It is proved, that the lead’s intoxication has unfavourable consequences on man’s organism. Grouring skeleton processes special sensitiveness on lead’s presence. Processes of reproduction and differentiation of cells provide metabolical and structural base for the development of cartilage and forming of bone in the increasing on the growth and the formation of skeleton’s bones. During the influence of lead’s salt the slowing of growth and formation of bone, of skeleton, the depression processes of proliferation and diffeerentiation of bone’s cells as well as biosynthetic processes in these cells take place. Besides during the lead’s intoxication the structural changes in cells take place. Key words: long tubular bones, bone's and cartilage cells, growth, formation, metaepiphysial and articular cartilages, radioautography, proliferation, lead’s intoxication. Aeneiaeth?ii ue?o iiaeyeo iaoeiaiio eiinoeueoaioo aeieoi?o a?ieia?/ieo iaoe, noa?oiio iaoeiaiio ni?a?ia?oieeo, caa?aeoth/?e a?aeae?eii oeeoieia?? oa a?noiaaiaco ?inoeoooo ciieia?? ?i. ?.?. Oiaeueaaocaia IAI Oe?a?ie ?iae?iiia?e Iaoae?? Aanee?ai?, ca oe?ii? aenieii?ioan?ei? ii?aaee uiaei aeeiiaiiy oe??? aeena?oaoe?eii? ?iaioe. I?aeienaii aei ae?oeo 1999 Oi?iao 60o84 1/16. Iai?? ionaoiee. Oe?aae 100 i?. Aaceiooiaii. Ae?oe – ?aaeaeoe?eii-aeaeaaie/ee a?aeae?e “Aaaea” AAeO (Eooeuee, i?. Aie?, 13). Cai.

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