Oe?a?inueeee aea?aeaaiee o?i?ei-oaoiieia?/iee oi?aa?neoao

Oa?aaa?a

?ai? Ieeieaeiae/

OAeE 547.333+547.541.52

Noa?ai?ciia?i? ai?ie oa ai?aee ?yaeo ii?ai?iaio. ?aaeoe?eia caeaoi?noue,
niaeo?aeuei? ia?aiao?e, a?ieia?/ia aeoeai?noue

02.00.03 — i?aai?/ia o?i?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa o?i?/ieo iaoe

Aei?i?iiao?ianuee

1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia ia eaoaae?? i?aai?/ii? o?i?? o?i?/iiai oaeoeueoaoo
Aei?i?iiao?ianueeiai aea?aeaaiiai oi?aa?neoaoo, I?i?noa?noai ina?oe
Oe?a?ie

Iaoeiaee ea??aiee: Caneoaeaiee ae?y/ iaoee ?
oaoi?ee

Oe?a?ie,
aeieoi? o?i?/ieo iaoe, i?ioani?

Ean`yi E?e?y
?aai?aia,

Aei?i?iiao?ianueeee aea?aeaaiee oi?aa?neoao,

eaoaae?a
i?aai?/ii? o?i??, i?ioani?

Io?oe?ei? iiiiaioe: aeieoi? o?i?/ieo iaoe,
i?ioani?

I?inyiee
Ieaenaiae? Aaneeueiae/,

Oe?a?inueeee
aea?aeaaiee o?i?ei-oaoiieia?/iee

oi?aa?neoao,
eaoaae?a i?aai?/ii? o?i??, i?ioani?

eaiaeeaeao
o?i?/ieo iaoe, noa?oee iaoeiaee

ni?a?ia?oiee

Oaaeaiei
Aieiaeeie? Naaae?eiae/,

iaoeiai-aeine?aeiee ?inoeooo a?ieia??

Aei?i?iiao?ianueeiai aea?aeaaiiai oi?aa?neoaoo,

noa?oee
iaoeiaee ni?a?ia?oiee

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee oaoi?/iee
oi?aa?neoao Oe?a?ie

“Ee?anueeee
iie?oaoi?/iee ?inoeooo”, eaoaae?a

i?aai?/ii?
o?i?? oa oaoiieia?? i?aai?/ieo

?a/iaei

Caoeno a?aeaoaeaoueny “ 3 ” ethoiai 2000 ?. i 13 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 08.078.03 i?e Oe?a?inueeiio aea?aeaaiiio
o?i?ei-oaoiieia?/iiio oi?aa?neoao? ca aae?anith: 49005, i.
Aei?i?iiao?ianuee, i?. Aaaa??ia, 8.

C aeena?oaoe??th iiaeia iciaeiieoenue o iaoeia?e a?ae?ioaoe?
Oe?a?inueeiai aea?aeaaiiai o?i?ei-oaoiieia?/iiai oi?aa?neoaoo

Aaoi?aoa?ao ?ic?neaiee “ 30 ” a?oaeiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao o?i?/ieo iaoe
O.A.Oioeiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Oe?ieee ?icaeoie o?i?? acioai?uoth/eo ea?eanieo
niieoe a inoaii? ?iee iaoiiaeaiee ?yaeii i?e/ei, iaei??th c yeeo ? ?o
aeniea ? ??ciiiai?oia a?ieia?/ia aeoeai?noue. Ia a?aei?io a?ae
noeueoiiai?ae?a ?yaeo ii?ai?iaio ea?aienai?aee, na/iaeie aeine?aeaeai? a
oeueiio ieai? iaaeinoaoiuei, i?ioa yaeythoueny, aacoiiaii,
ia?niaeoeaieie ia’?eoaie aeey i?iaaaeaiiy a?ieia?/ieo aeine?aeaeaiue.
Iayai?noue aei?noeiai a?oeeee?/iiai ea?eano ia?aoai?th? ?o o c?o/i?
iiaeae? aeey aea/aiiy caeaaeiino? o?i?/ieo ? a?ieia?/ieo aeanoeainoae
a?ae noa?aio?i?? iieaeoe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeine?aeaeaiiy
aeeiiaii a ?aieao aea?aeathaeaeaoii? oaie “Aiieneaei? niieoee.
Oai?aoe/ia aeine?aeaeaiiy ? ?ic?iaea iaoiae?a neioaco i?aeoe/ii ei?enieo
niieoe ia ?o iniia?”, caoaa?aeaeaii? Aieiaiei oi?aae?iiyi iaoee
I?i?noa?noaa ina?oe Oe?a?ie 20.06.1995 ?. (? aea?ae?a?no?aoe?? 0195 V
019434) oa aae?oaa o 1998 ?. (? aea?ae?a?no?aoe?? 06-84-98 “01.
01-IA/**-98). ?iaioa aeeiiaia ca i?aeo?eiee I?aeia?iaeii?
iaoeiai-ina?oiuei? i?ia?aie, a?aio ? PSU 083106 1998 ?.

Iaoa oa caaea/? aeine?aeaeaiiy. ?ic?iaea iaoiae?a neioaco iiaeo
iio?aeieo ai?i?a ?c ??ciiiai?oiei a?aeaeaeaiiyi ai?iia?oie a?ae
ii?ai?iaiiaiai ea?eano (noeueoiiai?ae?a, ea?aienai?ae?a, na/iaei oa
?i.), aea/aiiy ?o ?aaeoe?eii? caeaoiino? oa a?ieia?/ii? aeoeaiino?.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Cae?eniaii neioac aaeeei? a?oie
?ai?oa ia iienaieo ai?aeieo iio?aeieo noa?ai?ciia?ieo
ai?iiiaoeeii?ai?iai?a, aeine?aeaeaii ?o ?aaeoe?eio caeaoi?noue o
?aaeoe?yo aee?eoaaiiy, a?aeiiaeaiiy, aiieneaeoaaiiy; io?eiaii ?yae iiaeo
aee?eai?i?a ?c ea?eanii ii?ai?iaio, aea/aii ?o ?aaeoe?eio caeaoi?noue o
?aaeoe?yo c aeaeo?io?eueieie ?aaaaioaie.

Aia?oa i?iaaaeaii aiieneaeoaaiiy a?oi noa?ai?ciia?ieo ea?aienai?ae?a,
aee?enoeueoiiai?ae?a oa iiaeo na/iaei ?yaeo ii?ai?iaio. Anoaiiaeaii, ui
i?io?eaiiy ?aaeoe?? ieenethaaiiy ia caeaaeeoue a?ae noa?aio?i??
cai?nieea aeey ia?oi? a?oie niieoe ?, iaaiaee, caeaaeeoue aeey niieoe
aeaio inoaii?o a?oi, aea o aeiaaeeo aiaei-?ciia??a o ia?aaaaei?e
a?eueoino? aeiaaee?a ooai?ththoueny cai?uai? acaa?aiaeaie — i?iaeoeoe
aioo??oiueiiieaeoey?ii? oeeee?caoe??. C aeei?enoaiiyi aeaieo
eaaioiai-o?i?/ieo ?ic?aooie?a cai?iiiiiaaii ia?aeiio iiaeaeue aeey
iiyniaiiy i?e/ei aaoa?ioeeee?caoe?? aai ?? a?aenooiino? a ?aaeoe??
aiieneaeoaaiiy iio?aeieo 5-ai?iiiaoeeii?ai?iaio.

?ic?iaeaii iaoiae neioaco aee?ecai?uaieo acaa?aiaeai?a o ?aaeoe??
a?aeiiaeaiiy aiieneaeieo iio?aeieo aiaei-ea?aienai?ae?a ?yaeo
ii?ai?iaio.

Cae?eniaii neioac ?yaeo iiaeo iio?aeieo 5-ai?iiii?ai?i-2-?io. Aia?oa
anoaiiaeaii, ui eiai ?aaeoe?y c i-i?o?ioai?enoeueoioei?eaeii ia?aa?aa?
iaiaeiicia/ii a caeaaeiino? a?ae oiia cae?eniaiiy i?ioeano ? /anoeiai
caaa?oo?oueny ooai?aiiyi noeueoiiai?aeo ?c no?oeoo?ith
3-acaa?oeeeei[3.2.1]ieo-6-?io. Cae?eniaii neioac ai?iiaoeeii?ai?iaio oa
?ic?iaeaii iaoiae neioaco ai?iii?ii?eii?ai?iaio, neioaciaaii aaeeeee
?yae iiaeo iio?aeieo ia ?o iniia?.

Oia?oa aeine?aeaeaii ?aaeoe?? noeueoiiai?ae?a ? ai?ae?a ?yaeo ii?ai?iaio
c ??ciiiai?oiei a?aeaeaeaiiyi cai?nieea a?ae ea?eano c ia?ieneeeneioaie,
aeey an?o aeiaaee?a aeiaaaeaii ooai?aiiy o?eueee aiieneaeieo iio?aeieo.

Io?eiaii iia? aeai? i?i caeaaei?noue ianoeoeeaeii? aeoeaiino? nieae
?yaeo ii?ai?iaio a?ae noa?aio?i?? iieaeoe; anoaiiaeaii aieea ?yaeo
no?oeoo?ieo oaeoi??a ia oa?iaeieia?/io aeoeai?noue ai?ae?a,
noeueoiiai?ae?a ? na/iaei ?yaeo ii?ai?iaio.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. O ?iaio? cai?iiiiiaaii oeyoe
ooee?caoe?? aaaaoioiiaaeiiai a?aeoiaeo eienio?i?/ii? oa iaooiia?a?iaii?
i?iieneiaino? oeeeeiiaioaae??io aeey neioaco aaeeei? a?oie iiaeo
a?ieia?/ii aeoeaieo niieoe ?yaeo ii?ai?iaio oa aiieneii?ai?iaio. Aeey
ia?niaeoeaieo nieae ai?i?a aeyaeaii ianoeoeeaeio aeoeai?noue. ?yae
niieoe i?iyaeee oa?iaeieia?/io aeoeai?noue (aiaeueaaoe/io,
i?ioecaiaeueio, o?aiea?e?coth/o, aioea?iiene/io, i?ioenoaeiiio).

Iniaenoee aianie caeiaoaa/a. Aenia?eiaioaeuei? aeai? io?eiai? iniaenoi
caeiaoaa/ai, ui a?aa oaeiae o/anoue a iaaiai?aii? iaoeiaeo ?acoeueoao?a.
O ieaioaaii? aeine?aeaeaiiy e iaaiai?aii? ?acoeueoao?a a?aa o/anoue i.n.
OAeOOO e.o.i. A.I.Ean`yi. Oa?iaeieia?/i? aeine?aeaeaiiy i?iaaaeaii ia
eaoaae?? oa?iaeieia?? AeIA i?ae ea??aieoeoaii i?io. I.O.Ceaiei.
Eaaioiai-o?i?/i? oa iieaeoey?ii-iaoai?/i? ?ic?aooiee aeeiiaii aeioe.
AeAeO, e.o.i. N.?.Ieiaeoei.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe ?iaioe i?aaenoaaeai?
ia eiioa?aioe?yo ? eiia?anao: 2 eiia?an? “A?eue o ?a?ii?” ( ?niai?y,
1997 ?.), 4 i?aeia?iaeii? eiioa?aioe?? “Ooiaeaiaioaeuei? e i?eeeaaei?
aniaeoe o?ce/ii? o?i??” (THaineaa?y, 1998 ?.), 3 i?aeia?iaeiiio eiia?an?
iaoio?c?ieia?? (O?ieyiae?y, 1998 ?.), 15 i?aeia?iaeiiio neiiic?oi? c
iaaee/ii? o?i?? (Oioeaiae?y, 1998 ?.), 8 ?a?iiaenueeiio neiiic?oi? c
iae?iineoioa?iaeieia?? (Aano??y, 1998 ?.), Oe?a?inueei? eiioa?aioe?? c
o?i?? acioai?uoth/eo no?oeoo? (Oa?e?a, 1997 ?.), i?aeia?iaeii?
eiioa?aioe?? “Aeoeaaoe?y aeeai?a ? o?i?y ea?eanieo no?oeoo?” (Ee?a, 1998
?.), 16 Iaiaeae??anueeiio eiia?an? caaaeueii? oa i?eeeaaeii? o?i??
(N.-Iaoa?ao?a, 1998 ?.), 7 eiia?an? Na?oiai? Oaaea?aoe?? oe?a?inueeeo
e?eoaaeueieo oiaa?enoa (Oaeai?iae, 1998 ?.), 18 Oe?a?inuee?e
eiioa?aioe?? c i?aai?/ii? o?i?? (Aei?i?iiao?ianuee, 1998 ?.), 12
i?aeia?iaeiiio neiiic?oi? “O?i?y ?aoeaioi??a o o?aoueiio oeny/ie?oo?”
(?oae?y, 1999 ?.).

Ioae?eaoe??. Ca ?acoeueoaoaie aeine?aeaeaiue iioae?eiaaii a?n?i noaoae
(/ioe?e o “AEo?iae? i?aai?/ii? o?i??”) oa oace 18 aeiiia?aeae ca
iaoa??aeaie i?aeia?iaeieo ? iaoe?iiaeueieo eiioa?aioe?e.

No?oeoo?a aeena?oaoe?eii? ?iaioe. Aeena?oaoe?y neeaaea?oueny c anooio,
/ioe?ueio ?icae?e?a iaaiai?aiiy ?acoeueoao?a iaoeiaiai aenia?eiaioo,
aeaa c yeeo i?noyoue e?oa?aoo?i? aeai? i?i iaoiaee iaea?aeaiiy ?
a?ieia?/io aeoeai?noue ai?ae?a ?yaeo ii?ai?iaio oa cai?uaieo
acaa?aiaeai?a, aenia?eiaioaeueii? /anoeie, iniiaieo aeniiae?a, nieneo
aeei?enoaii? e?oa?aoo?e oa aeiaeaoe?a. ?iaioa aeeeaaeaia ia 247
noi??ieao oaenoo eiii`thoa?iiai iaai?o c aeiaeaoeaie, aeeth/a? 16
iaethie?a, 63 oaaeeoe?, 3 aeiaeaoee, nienie e?oa?aoo?e i?noeoue 158
aeaea?ae.

INIIAIee ci?no ?IAIOE

Neioac, niaeo?aeuei? ia?aiao?e ? ?aaeoe?eia caeaoi?noue aoeeeueieo
iio?aeieo noa?ai?ciia?ieo 5-ai?iiiaoee-a?oeeeei[2.2.1]aaio-2-?i?a

1.1. Ai?aee, ui aeeth/athoue a?oeeee?/iee o?aaiaio. Iaoiaee neioaco,
?aaeoe?eia caeaoi?noue oa a?ieia?/ia aeoeai?noue (iaeyae e?oa?aoo?e)

O e?oa?aoo?iiio iaeyae? i?eaaaeaii ?acoeueoaoe aeine?aeaeaiiy c neioaco
oa ?aaeoe?eii? caeaoiino? aeayeeo a?oi ai?ae?a, ocaaaeueiaii aeai? i?i
a?ieia?/io aeoeai?noue ea?eanieo ea?aienai?ae?a.

1.2. Neioac ? niaeo?aeuei? ia?aiao?e ea?aienai?ae?a ia iniia?
noa?ai?ciia?ieo 5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a. Aee?eoaaiiy
ai?ae?a

Aiae?c e?oa?aoo?ieo aeaieo i?i a?ieia?/io aeoeai?noue ai?ae?a ?c
ea?eanieie o?aaiaioaie na?ae/eoue i?i ia?niaeoeai?noue aeine?aeaeaiue o
aeaiiio iai?yieo. Iaie cae?eniaii neioac ai?ae?a ia iniia?
noa?ai?ciia?ieo ai?iiiaoeeii?ai?iai?a (1.2a,a); inoaii? io?eiaii a
?aaeoe?? a?aeiiaeaiiy a?aeiia?aeieo i?o?ee?a (1.1a,a) — a?aeiieo
i?iaeoeo?a eiiaeainaoe?? Ae?euena-Aeueaea?a oeeeeiiaioaae??io c
ae?eeii?o?eeii, aeey iiae?eo yeeo ia ?iaeea?aeoaeuei? noa?ai?ciia?e
aeei?enoaii oiieo ?aeoeo?eaoe?th.

Aeey iaea?aeaiiy ai?ae?a i?iaaaeaii ?aaeoe?? ai?i?a (1.2a,a) c
aia?ae?eaeaie aai oei?aia?ae?eaeaie ae?oaoe/ieo oa a?iiaoe/ieo eeneio.

O e?oa?aoo?? iienaii ?ai?oa niieoee (1.3a,a) oa (1.10a,a), neioac ?ioeo
iio?aeieo cae?eniaii aia?oa. No?oeoo?o io?eiaieo niieoe i?aeoaa?aeaeaii
aeaieie aiae?co ?*- oa ssI?-niaeo??a. A?aeianaiiy io?eiaieo ai?ae?a aei
aeci- oa aiaei-?yae?a noa?ai?ciia??a aeeiiaii ca aeiiiiiaith e?eoa???a,
?ic?iaeaieo ?ai?oa aeey noeueoiiai?ae?a oa na/iaei ?yaeo ii?ai?iaio.

Ia i?eeeaae? iaeiiai c ai?ae?a (1.6a) iieacaii iiaeeea?noue ?o
aee?eoaaiiy. Iaiao?aeiith oiiaith cae?eniaiiy i?ioeano ? aeei?enoaiiy
i?aeoaciaiai eaoae?co a nenoai? ??aeeia/oaa?aea oaca.

1.3. A?aeiiaeaiiy noa?ai?ciia?ieo
5-aoeeeai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a aethiia?ae?eaeii e?o?th

Io?eiai? ai?aee aeei?enoaii iaie aeey iaea?aeaiiy iiai? a?oie ai?i?a
?yaeo ii?ai?iaio (1.12a-1.15a, 1.12a-1.16a). ?o neioac cae?eniaii
a?aeiiaeaiiyi noa?ai?ciia?i?o ai?ae?a (1.3, 1.5-1.8) ae??th
aethiia?ae?eaeo e?o?th a eeiey/iio aaniethoiiio ao???.

Na?aae neioaciaaieo ai?i?a ?ai?oa aoei aea/aii eeoa noi?o
noa?ai?ciia??a (1.14a,a). No?oeoo?o ai?i?a (1.12-1.16) i?aeoaa?aeaeaii
ye aeaieie ?o ?*-niaeo??a, oae ? aeaieie niaeo??a ssI? 1I, aeey yeeo
aeyaeeeny i?eaeaoieie anoaiiaeai? ?ai?oa e?eoa??? aeey noa?aio?i?/ii?
?aeaioeo?eaoe?? iio?aeieo ?yaeo ii?ai?iaio.

1.4. ?aaeoe??
N-(i-i?o?iaaici?e)-aiaei-5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?io c
??ciiiai?oieie a?aeiiaieeaie

Ia i?eeeaae? iienaiiai aeua
N-(i-i?o?iaaici?e)-aiaei-5-ai?iiiaoee-a?oeeeei[2.2.1]aaio-2-?io (1.10a)
aea/aii iiaeeea?noue oaiinaeaeoeaii? o?ainoi?iaoe?? ooieoe?iiaeueieo
a?oi i?ae ae??th a?aeiiaiee?a ??cii? i?e?iaee — n??ee a eoaeiiio
na?aaeiaeu?, a?ae?aceio a?ae?aoo o i?enooiino? i?eaeaaiai eaoae?caoi?a
oa aethiia?ae?eaeo e?o?th. ?aaeoe?? caaa?oeeeny ooai?aiiyi a?aeiia?aeieo
ai?i?a (1.17, 1.21, 1.24), no?oeoo?o yeeo i?aeoaa?aeaeaii ye
niaeo?aeueieie iaoiaeaie (?*- oa II?-niaeo?ineii?y), oae ?
o?i?/ieie — ia?aoai?aiiyi ?o o a?aeiia?aei? iio?aei? (1. 18-1. 20, 1.22,
1.23).

1.5. Aea/aiiy ?aaeoe?eii? caeaoiino?
N-aee?e(a?aee?e)-5-ai?iiiaoee-a?oeeeei[2.2.1]aaio-2-?i?a o ?aaeoe?yo ?c
aeaeo?io?eueieie ?aaaaioaie

Aea/aii ?aaeoe?? aoi?eiieo ai?i?a (1.12-1.16) ?c ?yaeii aeaeo?io?eueieo
?aaaaio?a ??ciiiai?oii? i?e?iaee. Ia iniia? ai?io (1.14a) a i’yeeo
oiiaao io?eiaii ?yae iio?aeieo (1.25-1.30). I?e ae?? ia ai?ie
(1.12-1.16) oei?aia?ae?eaeo i-i?o?iaaicienoeueoiiiai? eeneioe a
aeaioaci?e nenoai? (aiaea-ao??) a i?enooiino? aiaeiiai ?ic/eio
a?ae?ieneaeo iao??th cae?eniaii neioac a?aeiia?aeieo noeueoiiai?ae?a
(1.31a-1.33a, 1.31a-1.35a). Aeey i?aeoaa?aeaeaiiy no?oeoo?e niieoe
aeei?enoaii ?*-niaeo?e, niaeo?e ssI? 1I ? 13N, a oaeiae aeaii??i?
niaeo?e COSY ? NOEZY ia?e noa?ai?ciia??a (1.31a,a).

Niinoa?aaeaiiy ca ?aaeoe?yie aoi?eiieo ai?i?a (1.12-1.16) iieacaei ?o
a?eueo oaeaeea e aeoeaia i?io?eaiiy a ii??aiyii? c aiaeia?/ieie
?aaeoe?yie ia?aeiieo ai?i?a (1.2a,a). I?aeaeuaiiy ?aaeoe?eii? caeaoiino?
aeia?a ocaiaeaeo?oueny c ?acoeueoaoaie oai?aoe/iiai ?ic?aooieo (AI1)
iniiaiino? aoi?eiieo ai?i?a, ioe?iaii? ye ??cieoe? oaieio ooai?aiiy
i?ioiiiaaieo oa iai?ioiiiaaieo ii aoiio acioo oi?i ai?i?a.

1.6. Aiieneaeoaaiiy ea?aienai?ae?a, iio?aeieo noa?ai?ciia?ieo
5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a

A inoaii? ?iee aoei aeyaeaii, ui aiieneaeoaaiiy a?oie
a?eenoeueoiiai?aeieo oa aeaio a?eeea?aaii?eueieo iio?aeieo aiaei-ai?io
(1.2a) noi?iaiaeaeo?oueny i?ioeanii aaoa?ioeeee?caoe?? c ooai?aiiyi
cai?uaieo acaa?aiaeai?a. Caaaeaiiyi oeueiai ?icae?eo ? aea/aiiy
aiieneaeoaaiiy aeci- oa aiaei-ai?ae?a, iienaieo o ?icae?e? 1.2. sse
ieenieee aeei?enoaii ??ciiiai?oi? ia?ieneeeneioe. Aeyaeeiny, ui
iacaeaaeii a?ae i???ioaoe?? cai?nieea ?aeeieie i?iaeoeoaie ?aaeoe?e
yaeeeny aiieneaee (1.36a, 1.39a, 1.40a, 1.43a, 1.36a-1.43a).

I?enooi?noue aiieneaeiiai oeeeeo no?iai aeiaaaeaii ca aeiiiiiaith
?*-niaeo??a niieoe (1.36-1.43) ii iayaiino? iiaeeiaiiy a iaeano? 845-855
ni-1. Iaea?eueo oa?aeoa?ieie a II? niaeo?ao ? neaiaee i?ioii?a
aiieneaeiiai oeeeeo a iaeano? 3.10-3.40 i.ae. Eeth/iaei iiiaioii
niaeo??a ssI? 13N yaeeeny neaiaee aiieneaeieo aoii?a aoaeaoeth a
iaeano? 49-50 i.ae.

Neioaoe/i? i?aeoiaee aei acaa?aiaeai?a

Iaoiaee iaea?aeaiiy cai?uaieo 4-acao?eoeeeei[4.2.1.03,7]iiiai?a (iaeyae
e?oa?aoo?e)

A iaeyae? e?oa?aoo?e iaaaaeaii aeai? uiaei iniiaieo iaoiae?a neioaco
cai?uaieo acaa?aiaeai?a ia iniia? iio?aeieo ii?ai?iaio.

2.2. Aiieneaeoaaiiy noa?ai?ciia?ieo aee?e-(aaicee-,
oeeeeiaaenee)-noeueoiiai?ae?a ?yaeo ii?ai?iaio

Aiieneaeoaaiiy a?eenoeueoiiai?ae?a ?yaeo ii?ai?iaio aea/aeiny ?ai?oa,
eiai i?io?eaiiy caeaaeeoue a?ae i???ioaoe?? cai?nieea a ea?ean? oa
noi?iaiaeaeo?oueny aaoa?ioeeee?caoe??th aeey niieoe aiaei-?yaeo. Iaoith
oeueiai aeine?aeaeaiiy ? aea/aiiy aiieneaeoaaiiy noeueoiiai?ae?a, ui
i?noyoue a?ey aoiia acioo cai?nieee ?ioeo oei?a. A yeino? ia’?eo?a
aiieneaeoaaiiy aeei?enoaii iienai? ?ai?oa noeueoiiai?aee
(2.2a,a-2.5a,a), a oaeiae iia? niieoee (2.1a,a).

Aiieneaeoaaiiy aeci-?ciia??a (2.1a, 2.2a, 2.4a, 2.5a) caaa?oeeiny
ooai?aiiyi a?aeiia?aeieo aiieneae?a (2.6-2.9). Aeey aeieaco no?oeoo?e
inoaii?o aeei?enoaii ?*-niaeo?e oa niaeo?e ssI? 1I ? 13N, aeaii??iee
niaeo? (COSY) niieoee (2.9).

Aeey i?iaeoeo?a aiieneaeoaaiiy noeueoiiai?ae?a (2.1a-2.3a, 2.5a)
aecia/aii no?oeoo?o acaa?aiaeai?a (2.10-2.13). Aeiyoeii noaa
noeueoiiai?ae (2.4a), ieenethaaiiy yeiai caaa?oeeiny ooai?aiiyi
aiieneaeo (2.14). No?oeoo?o inoaiiueiai no?iai aeiaaaeaii niaeo?aeueieie
iaoiaeaie oa aeaieie ?aioaaiino?oeoo?iiai aiae?co (iae.1).

Iae. 1. Iieaeoey?ia no?oeoo?a noeueoiiai?aeo (2.14).

Iaea?eueo ia?aeiieea? aeieace no?oeoo?e acaa?aiaeai?a (2.10-2.13)
io?eiaii i?e aiae?c? ?o niaeo??a ssI? 1I ? 13N. Eeth/iaeie iiiaioaie
i?ioiiieo niaeo??a ? iaeiii?ioiii? neaiaee — neiaeao i?ioiia I2 (3.5-3.7
i.ae.) oa aeoaeao i?ioiia I3 (3.2-3. 6 i.ae).

Neioac oa aiieneaeoaaiiy iiaeo na/iaei c ea?eanieie o?aaiaioaie

O 1996 ?. iienaii ooai?aiiy acaa?aiaeaiiaeo nenoai ia iniia? aeaio
a?eena/iaei aiaei-?yaeo a ?aaeoe?? inoaii?o ?c ia?ieneeeneioaie. O
ca’yceo c oeei o ?iaio? aeieeaaeii aeine?aeaeaii caaaeai? ?aaeoe??
aaeeei? a?oie noa?ai?ciia?ieo na/iaei, ui aeeth/athoue ??ciiiai?oi? ca
aeaeo?iiieie oa noa?e/ieie aeanoeainoyie cai?nieee. Neioac iiaeo na/iaei
(2.15-2.17), ye ? ?ai?oa iienaieo, cae?eniaii i?e ae?? ia ai?ie (1.2a,a)
a?aeiia?aeieo ?cioe?aiao?a o aaicieueiiio ?ic/ei?.

Aeei?enoaiiy aeaieo ?*- oa ssI?-niaeo?ineii?? aeicaieeei anoaiiaeoe
ooai?aiiy aiieneae?a (2.22-2.28) i?e ieenethaaii? aeci-na/iaei
(2.15a-2.21a) oa cai?uaieo acaa?aiaeai?a (2.29-2.35) — i?e ieenethaaii?
na/iaei aiaei-?yaeo. Caeiiii??i?noue caa??aa?oueny iaa?oue o aeiaaeeo
aiaei-noa?ai?ciia?ieo na/iaei ?c iaa?iiaoe/ieie (2.18a, 2.19a) oa
ia’?iieie o?aaiaioaie (2.20a, 2.21a) i?e aoii? acioo.

2.4. Iaea?aeaiiy N-aee?e(a?aee?e)acaa?aiaeai?a a?aeiiaeaiiyi
aiieneai?ae?a ?yaeo ii?ai?iaio

Iiaee iaoiae neioaco cai?uaieo acaa?aiaeai?a ?ic?iaeaii c aeei?enoaiiyi
aiieneai?ae?a (1.36a-1.42a). Aeey oeueiai cae?eniaii ?o a?aeiiaeaiiy
aethiia?ae?eaeii e?o?th a aaniethoiiio ao???. Ia?aeaeueii i?iaaaeaii
a?aeiiaeaiiy aeaio aeci-?ciia?ieo aiieneae?a (1.36a, 1.39a).

Niaeo?aeueiee aiae?c i?iaeoeo?a a?aeiiaeaiiy i?aeoaa?aeea iaea?aeaiiy
aiieneai?i?a (2.36, 2.37) ?c aiieneae?a (1.36a, 1.39a) ?
aee?e(a?aee?e)-cai?uaieo acaa?aiaeai?a (2.38-2.44) ?c yiieneai?ae?a
(1.36a-1.42a).

2.5. Oai?aoe/i? aniaeoe aea/aiiy ooai?aiiy cai?uaieo
4-acao?eoeee-ei[4.2.1.0.3,7]iiiai?a (acaa?aiaeai?a)

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui iio?aei? aiaei-ai?io (1.2a) a
?aaeoe?? c ia?ieneeeneioaie iiaiaeyoueny ii-??ciiio — ooai?ththoue
aiieneaee aai cai?uai? acaa?aiaeaie. Aeey aea/aiiy oaeoi??a, ui
aieeaathoue ia aaoa?ioeeee?caoe?th, i?iaaaeaii aiae?c ?yaeo
?ic?aooieiaeo ia?aiao??a o iieaeoeao aiieneae?a, ui ? e?ioeaaeie
i?iaeoeoaie (2.14, 1.36a, 1.37a, 1.39a) aai ?ioa?iaae?aoaie (2.45-2.48)
o ?aaeoe?? aiieneaeoaaiiy cai?uaieo ii?ai?iai?a. A?aeiia?aeii aei
ia?oiai c aeaio aeei?enoaieo i?aeoiae?a caeaoi?noue aei
aaoa?ioeeee?caoe?? aoei ioe?iaii ia i?aenoaa? ?ic?aoiaaieo cia/aiue
nii??aeiaiino? aei i?ioiia aoii?a acioo oa eenith.

?ic?aooiie, i?iaaaeaiee ca iaoiaeii AI1, iieacaa, ui naia
caeaoi?noue aoiia eenith aei i?ioiioaaiiy, ui ?noioiith i??ith
a?aeiia?aea? ca ?aaeoe?eio caeaoi?noue aiieneii?ai?iai?a, aeyaeea
a?aeiia?aei?noue aei aenia?eiaioaeueieo aeaieo. Aeiyoeii noaa eeoa
aiieneae (2.14). A?aeiia?aeii aei ae?oaiai i?aeoiaeo aeine?aeaeaii
eieae?caoe?th a?aie/ieo iieaeoey?ieo i?a?oaeae o aeine?aeaeoaaieo
iaeo?aeueieo oa i?ioiiiaaieo ii aoiio acioo (iiaeaeue A) oa eenith
(iiaeaeue A) iieaeoeao, i?e oeueiio aaaaeaeinue, ui aaoa?ioeeee?caoe?y
iaea?eueo eiia??ia ca oiia eieae?caoe?? ACII ia aoii? acioo ai?aeiiai
o?aaiaioa, a INII — ia aoaeaoeaaeo aoiiao iene?aiiaiai oeeeeo.

Iaea?eueo aaeaeith i?e oeueiio aeyaeeany iiaeaeue A, ui iieno?, aeania,
?aaeoe?th ?ice?eooy i?ioiiiaaiiai aiieneaeiiai oeeeeo. Aiae?c
eieae?caoe?? INII iieacaa, ui naia a iieaeoeao niieoe, ui
oeeee?cothoueny, INII iaeneiaeueii eieae?ciaaia ia aoiiao N3 ea?eano,
ii eio?ei ? cae?enith?oueny aioo??oiueiiieaeoey?ia aoaea cai?nieea. I?e
oeueiio aianie o INII i?a?oae? aoiia N3 (a?ae 25.5% aei 33.6%), a oaeiae
aenia?eiaioaeueii aeyaeaia iiaeeea?noue aaoa?ioeeee?caoe?? c?inoathoue o
oaeiio ?yae?: 1.37a(2.46(2.14(1.39a(1.36a(2.45(2.47(2.48.

3. Iio?aei? ai?i?a ?yaeo ii?ai?iaio c ??ciiiai?oiei a?ae-aeaeaiiyi
cai?uaii? ai?iia?oie a?ae aoaeaoeaaiai ea?eano

Iaoith aeeeaaeaiiai o oeueiio ?icae?e? aeine?aeaeaiiy ? neioac oa
aea/aiiy ?aaeoe?eii? caeaoiino? ai?i?a (3.1-3.3) ?c ??ciiiai?oiei
a?aeaeaeaiiyi ai?iia?oiie a?ae a?oeeee?/iiai ea?eano.

Neioac oa ia?aoai?aiiy aiaei-5-ai?iia?oeeeei[2.2.1]aaio-2-?io

Ai?i (3.1) oa eiai iio?aei? aei oaia??oiueiai /ano aea/aii
iaaeinoaoiuei, i?ioa a?aeii? ai?aee ia eiai iniia? c aeanoeainoyie
aa?a?oeeae?a. Ai?i (3.1) io?eiaii ca iaaaaeaiith ieae/a noaiith e
ioa?aeoa?eciaaii ?yaeii iio?aeieo (3.5-3.9), no?oeoo?o inoaii?o
i?aeoaa?aeaeaii eiiieaenii niaeo?aeueieo iaoiae?a.

A?aeianaiiy neaiae?a o niaeo?ao II? aeeiiaii ca aeiiiiiaith aeaii??iiai
niaeo?a COSY na/iaeie (3.7), aea/aii oaeiae ?? ian-niaeo?aeueiee
?iciaae.

3.2. Ia?aa?oioaaiiy a ?aaeoe?? a?eenoeueoii?ethaaiiy
aiaei-5-ai?ii-a?oeeeei[2.2.1]aaio-2-?io

I?e aea/aii? ?aaeoe?? ai?io (3.1) c i-i?o?ioai?enoeueoii?eoei?eaeii aoei
c?iaeaii aeniiaee i?i ??ciiiai?oia ?? i?io?eaiiy a caeaaeiino? a?ae oiia
i?ioeano e ooai?aiiy ii?yae ?c “ii?iaeueiei” i?iaeoeoii i?iaeoeoo
ia?aa?oioaaiiy (3.10).

Ia i?aenoaa? aeaieo ?*-, ssI?- ? ian-niaeo??a aeey niieoee (3.10)
cai?iiiiiaaii no?oeoo?o iio?aeiiai 3-acaa?oeeeei[3.2.1]ieo-6-?io, ia
ei?enoue yei? iaea?eueo e?aniiiiaii na?ae/aoue niaeo?e ssI?, ui
a?aeia?aaeathoue aenieo neiao??th iieaeoee. Ianeai?noue noeueoiiai?aeo
(3.5) a oiiaao, ui i?ecaiaeyoue aei ia?aa?oioaaiiy, aeicaieeea
i?eioneaoe i?io?eaiiy ia?aa?oioaaiiy ia noaae?? ai?io (3.1A). I?iaaaeai?
iaoiaeii IIO ?ic?aooiee i?aeoaa?aeeee aenieo oa?ii-aeeiai?/io
no?ee?noue ia?aa?oiiaaiiai ai?io (3.1A) o ii??aiyii? c? niieoeith (3.1).

3.3. Neioac aiaei-5-(2`-ai?iiaoee)a?oeeeei[2.2.1]aaio-2-?io ?
i?iaeoeo?a eiai aca?iiae?? c aeaeo?io?eueieie ?aaaaioaie

Ai?i (3.2) io?eiaii ia iniia? i?iaeoeoo ae??iiaiai neioaco
oeeeeiiaioaae??io c ae?iea?iii ca a?aeiiith iaoiaeeeith. Ia iniia? ai?io
(3.2) o ?aaeoe?yo ?c aeaeo?io?eueieie ?aaaaioaie ??ciiiai?oii? i?e?iaee
neioaciaaii ?yae iiaeo iio?aeieo (3.13-3.21), no?oeoo?o yeeo
i?aeoaa?aeaeaii niaeo?aeueieie iaoiaeaie.

3.4. Neioac 5-(3`-ai?iii?ii?e)a?oeeeei[2.2.1]aaio-2-?io ? eiai iio?aeieo

Aeey neioaco iiaiai ai?io (3.3) aeei?enoaii iaeei ?c aa??aio?a
?aaeoe?? Eiaaaiaaaey, ui aeeth/a? eei’yo?iiy ?aaaaio?a o i??eaeei? c
aeiaeaaaiiyi eaoae?oe/ii? e?eueeino? i?ia?eaeeio. I?ney a?aeiiaeaiiy
i?ii?aeiiai i?o?eeo (3.22) aethiia?ae?eaeii e?o?th ai?i (3.3) aeae?eaii
ia?aaiieith oa ioa?aeoa?eciaaii ?yaeii iio?aeieo (3.23-3.28). No?oeoo?o
inoaii?o i?aeoaa?aeaeaii niaeo?aeueieie iaoiaeaie.

3.6. Aiieneaeoaaiiy ai?ae?a ?yaeo ii?ai?iaio c ??ciiiai?oiith
eieae?caoe??th ai?iia?oie ii a?aeiioaiith aei aoaeaoeaaiai ea?eano

Iaea?aeaiiy iio?aeieo ai?i?a ?c ??ciiiai?oiei a?aeaeaeaiiyi cai?nieea
a?ae iiaea?eiiai ca’yceo aeicaieeei i?iaeiaaeeoe aea/aiiy iiaeeeaino?
?oiuei? aaoa?i-oeeee?caoe?? o ?aaeoe?yo ?c ia?ieneeeneioaie. ?aaeoe??
?yaeo niieoe (3.5, 3.6, 3.13, 3.15, 3.23) i?ecaaee a on?o aeiaaeeao aei
ooai?aiiy aiieneaeieo niieoe (3.29-3.33).

A aeiaei?e c ?aaeoe?e ia aoei aeyaeaii aaoa?ioeeee?caoe??, yea, iaaia,
oa?aeoa?ia o?eueee aeey iio?aeieo ai?io (1.2a).

4. A?IEIA?*IA AEOEAI?NOUe NEIOACIAAIEO niieoe

Ia’?eoaie aea/aiiy a?ieia?/ii? aeoeaiino? a aeai?e ?iaio? aoee ai?ie,
ea?aienai?aee, noeueoiiai?aee ? na/iaeie. I?aaenoaaieee ia?oi? a?oie (oa
?o nie?) aeine?aeaeai? ye iioaioe?ei? ianoeoeeaee, i?aaenoaaieee ?ioeo
a?oi — ye iioaioe?ei? oa?iaeii?aia?aoe.

Ianoeoeeaeia aeoeai?noue iio?aeieo ea?eanieo ai?i?a

sse iioaioe?ei? ianoeoeeaee aea/aii ai?ie (1.2a,a), ?o nie? c
(-oei?aoeeoinoiiiaith eeneioith (ao?aeii) (4.1a,a), iaoaiai?iiaith
eeneioith (4.2a,a) oa ii?ai?iaiea?aiiiaith eeneioith (4.3).

O i?ioean? aeine?aeaeaiue aea/aii oae? aeaee aeoeaiino?: ooia?oeeaeia,
ooia?noaoe/ia,aaeoa?eoeeaeia, ??no?aaoethth/a. Ciaeaeaii ia?niaeoeai?
ia’?eoe:

— i?aia?aoe aeey ai?ioueae c oai?iaaie ?ineei — nie? (4.1a,a);

— ooia?oeeae aeey i?io?eaeoeee oai?ia ?ineei — n?eue (4.1a);

— i?aia?ao aeey ai?ioueae c aaeoa??icaie iai/?a — n?eue (4.1a);

— ?aoa?aeaioe (4.1a, 4.1a);

— noeioeyoi?e ?inoo ei?ai?a (1.2a, 4.3), noeioeyoi? ?inoo iaaecaiii?
/anoeie ?ineei (1.2a), noeioeyoi?e noiaeino? ian?iiy (1.2a,a, 4.1a,a).

C a?oie niieoe aeae?eai? i?aia?aoe eiia?iiaaii? ae?? — ooia?oeeaee,
?aoa?aeaioe (4.1a,a), ooia?oeeae, aaeoa?eoeeae (4.1a), ooia?oeeae,
noeioeyoi? noiaeino? ian?iiy (4.1a). Io?eiaii aeai? i?i nooo?aee aieea
noa?aio?i?/ieo iniaeeainoae ai?i?a ia neeo a?ieia?/ii? aeoeaiino?.

4.2. Oa?iaeieia?/ia aeoeai?noue noeueoiiai?ae?a, ea?aienai?ae?a ?
na/iaei ?yaeo ii?ai?iaio

sse ia’?eoe aeey aea/aiiy oa?iaeieia?/ii? (aiaeueaaoe/ii?,
i?ioenoaeiiii?, aioea?iiene/ii?, o?aiea?e?coth/i?) aeoeaiino? ia?ai? o?e
a?oie niieoe. O ia?oo aa?eoee ea?aienai?aee, noeueoiiai?aee oa na/iaeie
?yaeo ii?ai?iaio. Aeey ii??aiyiiy aeei?enoaii iaeaea? noa?ai?ciia?i?
oi?ie ?ai?oa aea/aieo noeueoiiai?ae?a (4.4a,a), ui i?iyaeee iaeaeuo
aeoeai?noue. Aaaaeaiiy aiieneaeiiai oeeeeo a iieaeoee ai?ae?a (1.10a,a)
i?ecaaei aei cieaeaiiy on?o aeae?a aeoeaiino?. A on?o ia?ao
noa?ai?ciia?ieo niieoe aeci-?ciia?e a?ae??ciythoueny ye i?aaeei iaio
ae?aaeaiith aiaeueaaoe/iith oa a?eueo neeueiith i?ioenoaeiiiith
aeoeai?noth. Ii??aiyiiy ae?? noeueoiiai?aeo (4.4a) oa eiai aee?eiaaiiai
aiaeiaa (1.33a) iieacaei iiyao i?inoaeiiii? aeoeaiino? cai?noue cia/ii?
i?ioenoaeiiii? ae??.

Aiae?c aeoeaiino? niieoe ae?oai? a?oie (2.4a, 2.5a, 4.4a-4.7a) aeicaieea
c?iaeoe aaaeeeaee aeniiaie i?i i?aeaeuaiiy aeoeaiino? i-i?o?i- ?
i-oei?oai?enoeueoiiai?ae?a (4.4a, 4.5a) o ii??aiyii? c iacai?uaiei
aiaeiaii (2.4a), cia/ia ?? cieaeaiiy (oa cieeiaiiy aeayeeo aeae?a) i?e
aaaaeaii? aaiceeueiiai, oeeeeiaaeneeueiiai e, iniaeeai, oinoii?eueiiai
cai?niee?a. Inoaiiy niieoea (4.7a) aeyaey? eeoa iii??io o?aiea?e?coth/o
aeoeai?noue. C ?ioiai aieo, o?eueee aaiceenoeueoiiai?ae (2.5a) i?iyaea
i?ioecaiaeueio aeoeai?noue.

I?e aeine?aeaeaii? niieoe o?aouei? a?oie iieacaia ?ieue
a?aeaeaeaiiy i-i?o?ioai?enoeueoii?eueii? a?oie a?ae a?oeeee?/iiai
ea?eano ia nooi?iue ? oa?aeoa? iae?io?iiii? ae?? i?aia?ao?a (niieoee
3.5, 3.10, 3.13, 4.4a, 4.8). A?aeii? ai?aee 4.4a oa 4.8 aeei?enoaii aeey
ii??aiyiiy. Niieoea (4.4a) aeyaeeany iaea?eueo ia?niaeoeaiith a ?yaeo
i?o?inoeueoiiai?ae?a, i?iyaeaoe iaeaeuo aiaeueaaoe/io oa i?ioenoaeiiio
aeoeai?noue. Niieoea (3.13) aeyaeea iii??io aeoeai?noue a on?o aeaeao
iae?io?iiii? ae??.

Aeoeai?noue niieoe (3.5, 3.10) ia? ?yae caaaeueieo ?en — a?aenooi?noue
i?ioe-noaeiiii? ae?? oa ia?aaaaeath/a o?aiea?e?coth/a aeoeai?noue (129.8
? 223. 3%).

AENIIAEE

Cae?eniaii neioac ? aea/aii ?aaeoe?eio caeaoi?noue (aee?eoaaiiy,
a?aeiiaeaiiy, aiieneaeoaaiiy) iiaeo ai?ae?a ia iniia? noa?aio?i?/ii
iaeii??aeieo 5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a. ?ic?iaeaii iaoiae
neioaco iiai? a?oie aee?eai?i?a ?yaeo ii?ai?iaio, aea/aii ?aaeoe?eio
caeaoi?noue inoaii?o o ?aaeoe?yo ?c aeaeo?io?eueieie ?aaaaioaie.

2. Aeyaeaii ??ciiiai?oia i?io?eaiiy ?aaeoe?e ??cieo iio?aeieo
5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a ?c ia?ieneeeneioaie. Ai?aee
oeueiai ?yaeo, ye aeci-, oae ? aiaei-eiio?ao?aoe??, ia?aoai?ththoueny a
aiieneaei? iio?aei?; o?ainoi?iaoe?y aee?enoeueoiiai?ae?a ? na/iaei
caeaaeeoue a?ae i???ioaoe?? cai?nieea a ea?eaniiio o?aaiaio?:
aeci-?ciia?e ooai?ththoue aiieneaee, o aeiaaeeo aiaei-noa?ai?ciia??a
io?eiaii cai?uai? acaa?aiaeaie
(aeci-2-a?ae?iene-4-acao?eoeeeei[4.2.1.03,7]iiiaie). ?ic?iaeaii iaoiae
neioaco aee?ecai?uaieo acaa?aiaeai?a a?aeiiaeaiiyi aiieneaeeo iio?aeieo
aiaei-ea?aienai?ae?a aethiia?ae?eaeii e?o?th.

3. Cai?iiiiiaaii ia?aeii? eaaioiai-o?i?/i? iiaeae?, ui aeicaieythoue
ioe?ieoe iiaeeea?noue aaoa?ioeeee?caoe?? iio?aeieo
aiaei-5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?io a ?aaeoe?yo ?c
ia?ieneeeneioaie.

4. Cae?eniaii neioac 5-ai?iia?oeeeei[2.2.1]aaio-2-?io,
5-(2`-ai?ii-aoee)a?oeeeei[2.2.1]aaio-2-?io oa ?ic?iaeaii iaoiae neioaco
5-(3`-ai?iii?i-i?e)a?oeeeei[2.2.1]aaio-2-?io, ia iniia? yeeo io?eiaii
aaeeeo a?oio iiaeo iio?aeieo, aea/aii ?o niaeo?aeuei? ia?aiao?e.

5. Aeyaeaii iacae/ia ia?aa?oioaaiiy a ?aaeoe??
5-ai?iia?oeeeei[2.2.1]aaio-2-?io c i-i?o?ioai?enoeueoii?eoei?eaeii, ui
i?ecaiaeeoue aei iiyae iiai? aaoa?inenoaie
3-acaa?oeeeei[3.2.1]ieo-6-?io. Ca aeiiiiiaith aeaieo oai?aoe/ieo
?ic?aooie?a aea/aii i?io?eaiiy oeueiai i?ioeano.

6. O ?acoeueoao? aea/aiiy aiieneaeoaaiiy noeueoiiai?ae?a oa
ea?aienai?ae?a ?yaeo ii?ai?iaio c ??ciiiai?oiei a?aeaeaeaiiyi cai?nieea
a?ae ea?eano anoaiiaeaii, ui ?aaeoe?? aeaieo a?oi niieoe c
ia?ieneeeneioaie ia?aa?aathoue c ooai?aiiyi aiieneae?a ye ?aeeieo
i?iaeoeo?a ieeniaiiy.

Aeey a?oie nieae noa?ai?ciia?ieo 5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a
aeyaeaia ianoeoeeaeia (ooia?oeeaeia, ooia?noaoe/ia, aaeoa?eoeeaeia,
??no?aaoethth/a) aeoeai?noue, anoaiiaeaii caeaaei?noue oa?aeoa?o oa neee
inoaiiuei? a?ae noa?aio?i?/ieo iniaeeainoae ai?i?a.

I?e i?iaaaeaii? oa?iaeieia?/ieo aeine?aeaeaiue a?oie iiaeo niieoe
(noeueoiiai?ae?a, ea?aienai?ae?a, na/iaei) anoaiiaeaii aieea ?yaeo
no?oeoo?ieo oaeoi??a (oa?aeoa?o cai?nieea a ea?ean?, eiai
a?aeaeaeaiino?, i???ioaoe?? oa ?i.) ia aeae oa neeo iae?io?iiii? ae??
i?aia?ao?a.

Iniiaiee ci?no aeena?oaoe?? aeeeaaeaii o oaeeo ioae?eaoe?yo:

1. Eanueyi E.E., Oa?aaa?a E.I., Naaaeueaaa I.A., Eanueyi A.I. Neioac
N-aaicee-yeci-2-aeae?iene-4-acao?eoeeeei[4.2.1.03,7]iiiaia // AEo?i.
i?a. oeiee. — 1997. — O. 33, aui. 9. — N. 1429-1430.

2. Eanueyi E.E., Oa?aaa?a E.I. Niaeo?u ssI? 1I a ?yaeo aieaeia n
ii?ai?iaiiaui o?aaiaioii. // I?eaei?i?ianueeee iaoeiaee a?niee. — 1997.
-N2(13). — N.39-44.

3. Eanueyi E.E., E?aniianeay I.TH., Oa?aaa?a E.I., Eanueyi A.I.
Iaaeoaciue eaoaeec a ?aaeoeeyo acioniaea?aeaueo caiauaiiuo ii?ai?iaiia
// AEo?i. i?a. oeiee. — 1998. — O. 34, aui. 6. — N. 944-946.

4. Eanueyi E.E., Oa?aaa?a E.I., E?aa/aiei A.A., Eanueyi A.I. Neioac,
no?oeoo?a e niaeo?u II? noa?aieciia?iuo
N-aaicee-N-i-ieo?ioaieenoeueoiiee-5-aieiiiaoeeaeoeeeei[2.2.1]aaio-2-aiia
// Aanoiee AeAO, na?. oei. — 1998. — Aui. 2. — N. 126-131.

5. Eanueyi A.I., Oa?aaa?a E.I., Ceaiei A.O., Ieiaeoue N.E.,
EanueyiE.E. Noa?aieciia?iua
N-aeeee(a?aeeee)-5-aieiiiaoeeaeoeeeei[2.2.1]aaio-2-aiu. Neioac, niaeo?u
ssI? 1I e ?aaeoeee n yeaeo?ioeeueiuie ?aaaaioaie // AEo?i. i?a. oeiee. —
1999. — O. 35, aui. 7. — N. 1042-1055.

6. Eanueyi A.I., Oa?aaa?a E.I., Eanueyi E.E. Ia?aa?oiie?iaea a ?aaeoeee
a?eenoeueoiieee?iaaiey yiaei-5-aieiiaeoeeeei[2.2.1]aaio-2-aia // AEo?i.
i?a. oeiee. — 1999. — O. 35, aui.4. — N. 647-648.

7. Ceaiei I.O., Iai/o? A.?., Eanueyi E.?., Ii?eoei A.?., Eanueyi A.I.,
Aeai/aiei I.I., Oa?aaa?a ?.I. I?i aca?iia?aeiineie i?ae aiaeueaacoth/ith
? i?ioenoaeiiiith aeoeai?noth a ae?? e?ea?nueeeo i?aia?ao?a //
O?ceieia?/iee aeo?iae. — 1998. — O. 44, N 3. — N. 31-32.

8. Kasyan L.I., Tarabara I.N., Krishchik O.V., Kasyan A.O. The study of
1H NMR spectra in the row of amides with norbornene fragment, which
possess biological activity // Spectroscopy of Biological Molecules:
Modern Trends. P.Carmona, R.Navarro and A.Hernanz (eds). Annex. Madrid.
— 1997.- P. 121-122.

9. Eanueyi E.?., Oa?aaa?a ?.I., Ieiaeoee N.?., Naaaeue?aa I.I.
Acaa?aiaeaie ia iniia? ai?ae?a ii?ai?iaio // Oac. aeii. Oe?a?inueei?
eiioa?aioe?? c oei?? acio-ai?uoth/eo niieoe. Oa?e?a, Oe?a?ia. — 1997. —
N. 36.

10. Zlenko H., Kasyan L., Mamchur V., Demchenko H., Kasyan A.,
Krasnovski O., Tarabara I., Budchenko S. The comparison of the analgetic
and anticonvulsive activity in the nitrosubstitutive of sulfonamides
derivatives line // Abstr. of II Congress of European Federation of IASP
Chapters «Pain in Europe». Barcelona, Spain. — 1997.- P. 262-263.

11. Kasyan A.O., Zlenko H.T., Tarabara I.N., Kasyan L.I. The
Investigation of Connection of the Biological Activity and Structure in
the Row of Amines Derivatives with Carcass Fragments // Oac. aeii.
I?aeia?iaeii? eiioa?aioe?? «Aeoeaaoe?y aeeai?a oa o?i?y ea?eanieo niieoe
(CAYE’98). Ee?a, Oe?a?ia. — 1998. — N. B-6.

12. Kasyan L.I., Tarabara I.N., Kasyan A.O. The Pathways of Synthesis
and Structure of a New Group of the N-Sulfonyl Derivatives of
N-Alkyl(Aralkyl)-5-Aminomethylbicyclo[2.2.1]hept-2-enes // Oai aea. — N.
B-5.

13. Kasyan L.I., Zlenko H.T., Kasyan A.O., Tarabara I.N., Krishchik
O.V. Synthetic approaches to biologically active amides with skeleton
fragments // XVI Mendeleev Congress of General and Applied Chemistry.
St.-Petersberg, Russia. — 1998. — Vol. 4. — P. 53-54.

14. Kasyan L.I., Okovity S.I., Tarabara I.N., Podolyan E.A. Theoretical
and spectral investigation in the series of derivatives of norbornene
series amines // 4th International Conference on Fundamental and Applied
Aspects of Physical Chemistry. — Belgrad, Yugoslavia. — 1998. — P.
151-152.

15. Zlenko H., Skotchko-Volkova T., Mamchur V., Demchenko H., Kasyan
L., Tarabara I. The pathophisiological aspects of hypoxial stress and
its correction // III International Congress of Pathophysiology. Lahti,
Finland. — 1998. — P. 27.

16. Zlenko H.T., Kasyan L.I., Mamchur V.I., Kasyan A.O., Tarabara
I.N.,Budchenko S.I. The Analgesic Activity of Arylsulfon- and
Arylcarboxamides with bicyclic Carcasses // 8th Central European
Neuropsychopharmacological Sympisium. Vienna, Austria.- P. 307-308.

17. Kasyan L.I., Zlenko H.T., Kasyan A.O., Tarabara I.N. Biologically
active compounds with norbornene carcass // XVth EFMC International
Symposium on Medicinal Chemistry. Edinburg, Scottland. — 1998. — P. 204.

18. Eanueyi A.I., Ieiaeoee N.I., Aeie/aiei I.A., Oa?aaa?a I.I., Iiaeieyi
?.I. Aiiie c aioeeeei/iei ea?eanii, ?o iioiaeii. Aoaeiaa, iniiaiinoue,
niaeo?aeueii ia?aiao?e // XVIII Oe?a?inueea eiioa?aioeiy c i?aaii/ii?
oiii?. Aeiii?iiao?ianuee, Oe?a?ia. — 1998. — N. 251.

19. L.I.Kasyan, H.T.Zlenko, A.O.Kasyan, I.N.Tarabara. The role of space
isomerism in a series of substituted norbornenes in manifestation of
neurotropic action of preparates // Abstr. of papers of 12th
Camerino-Noordwijkerhout Symposium «Receptor Chemistry towards the third
millennium «. Camerino, Italy. — 1999. — P 67.

AIIOAOe?ss

Oa?aaa?a ?.I. Noa?ai?ciia?i? ai?ie oa ai?aee ?yaeo ii?ai?iaio.
?aaeoe?eia caeaoi?noue, niaeo?aeuei? ia?aiao?e, a?ieia?/ia aeoeai?noue.
— ?oeiien.

Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa o?i?/ieo iaoe ca
niaoe?aeuei?noth 02.00.03 — i?aai?/ia o?i?y. Oe?a?inueeee aea?aeaaiee
o?i?ei-oaoiieia?/iee oi?aa?neoao, Aei?i?iiao?ianuee, 1999 ?.

Cae?eniaii neioac iiai? a?oie ai?aeieo iio?aeieo noa?ai?ciia?ieo
5-ai?iiiaoeea?oeeeei[2.2.1]aaio-2-?i?a, aea/aii ?o ?aaeoe?eio
caeaoi?noue o ?aaeoe?yo aee?eoaaiiy, a?aeiiaeaiiy, aiieneaeoaaiiy.
?ic?iaeaii iaoiae neioaco iiaeo aee?eai?i?a ?yaeo ii?ai?iaio.
Aeine?aeaeaii aiieneaeoaaiiy a?oi noa?ai?ciia?ieo ai?ae?a,
aee?enoeueoiiai?ae?a ? na/iaei ?yaeo ii?ai?iaio, aeey
aiaei-noa?ai?ciia??a aeaio inoaii?o a?oi aecia/aii a ia?aaaaei?e
a?eueoino? aeiaaee?a no?oeoo?o i?iaeoeo?a aioo??oiueiiieaeoey?ii?
oeeee?caoe?? — cai?uaieo acaa?aiaeai?a. ?ic?iaeaii iaoiae neioaco
aee?ecai?uaieo acaa?aiaeai?a. Cae?eniaii neioac ai?iiii?ai?iaio,
ai?iiaoeeii?ai?iaio ? ?ic?iaeaii iaoiae neioaco ai?iii?ii?eii?ai?iaio,
ia ?o iniia? io?eiaii aaeeeee ?yae iiaeo iio?aeieo (ai?ae?a,
noeueoiiai?ae?a, na/iaei oa ?i.), aea/aii aiieneaeoaaiiy inoaii?o.
Aeyaeaii e iaaiai?aii iacae/ia ia?aa?oioaaiiy a ?aaeoe?? ai?iiii?ai?iaio
c i-i?o?ioai?enoeueoii?eoei?eaeii, ui i?ecaiaeeoue aei ooai?aiiy
aaoa?inenoaie ?yaeo 3-acaa?oeeeei[3.2.1]ieo-6-?io. I?e aeine?aeaeaii?
ianoeoeeaeii? aeoeaiino? a?oie nieae ai?i?a ?yaeo ii?ai?iaio oa
oa?iaeieia?/ii? aeoeai?noue a?oie iiaeo ai?ae?a, noeueoiiai?ae?a ?
na/iaei aeyaeaii aieea ??ciiiai?oieo /eiiee?a (oei cai?nieea, eiai
i???ioaoe?y e ?i.) ia oa?aeoa? ? neeo aeoeaiino?.

Eeth/ia? neiaa: ai?ie ?yaeo ii?ai?iaio, ai?aee, noeueoiiai?aee,
na/iaeie, aiieneaeoaaiiy, acaa?aiaeaie, aaoa?ioeeee?caoe?y, a?ieia?/ia
aeoeai?noue.

summary

Tarabara I.N. Stereoisomeric amines and amides of norbornene row.
Reactionary ability, spectral parameters and biological activity. —
Manuscript.

Thesis for a candidate`s degree of chemical sciences on specialty
02.00.03 — organic chemistry. — Ukrainian State Chemical Technology
University, Dnepropetrovsk, 1999.

The synthesis of new amide derivatives group of stereoisomeric
5-aminomethylbicyclo[2.2.1]hept-2-enes has been realized, their
reactionary ability in reactions alkilation, redaction and epoxidation
has been investigated. The dependence of the course of a epoxidation
reaction of the stereoisomeric amides, alkylsulfonamides and ureas
based on exo-(and endo-)5-aminomethylbicyclo[2.2.1]hept-2-enes on the
substituents orientation has been established. The method of alkyl
substituted azabrendanes synthesis has been developed. The synthesis of
aminonorbornene and aminoethylnorbornene has been realized, and the
method of aminopropylnorbornene synthesis has been developed; on their
basis the extensive series of a new derivatives (amides, sulfonamides,
ureas etc.) have been obtained, epoxidation of lasts was investigated.
It was demonstrated the influence of the various factors (type of the
substituent, it orientation etc.) on a character and force of pesticide
activity of amines salts and pharmacological activity of new amides,
sulfonamides and ureas of the norbornene series.

Key words: amines of norbornene series, amides, sulfonamides, ureas,
epoxidation, azabrendanes, heterocyclization, biological activity.

aiiioaoeess

Oa?aaa?a E.I. Noa?aieciia?iua aieiu e aieaeu ?yaea ii?ai?iaia.
?aaeoeeiiiay niiniaiinoue, niaeo?aeueiua ia?aiao?u, aeieiae/aneay
aeoeaiinoue. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa oeie/aneeo iaoe ii
niaoeeaeueiinoe 02.00.03 — i?aaie/aneay oeiey. Oe?aeineee
ainoaea?noaaiiue oeieei-oaoiieiae/aneee oieaa?neoao, Aeiai?iiao?iane,
1999.

Inouanoaeai neioac iiaie a?oiiu ea?aienaieaeiuo i?iecaiaeiuo ia iniiaa
noa?aieciia?iuo 5-aieiiiaoeeaeoeeeei[2.2.1]aaio-2-aiia, eco/aia eo
?aaeoeeiiiay niiniaiinoue a ?aaeoeeyo aeeeee?iaaiey, ainnoaiiaeaiey.
?ac?aaioai iaoiae neioaca iiauo noa?aieciia?iuo
N-aeeee(a?aeeee)-5-aieiiiaoeeaeoeee-ei[2.2.1]aaio-2-aiia, ?aaeoeeiiiay
niiniaiinoue iineaaeieo ioeaiaia eae n iiiiuueth aeaiiuo oai?aoe/aneeo
?an/aoia, oae e oeie/aneei iooai a ?aaeoeeyo n yeaeo?ioeeueiuie
?aaaaioaie ?acee/iie i?e?iaeu. Eco/aii niaeo?aeueiia iiaaaeaiea iiauo
aieiia e i?iecaiaeiuo ia eo iniiaa, ii?aaeaeaiu e?eoa?ee aeey
noa?aioeie/aneie eaeaioeoeeaoeee iineaaeieo. Enneaaeiaaii
yiieneaee?iaaiea a?oii noa?aieciia?iuo ea?aienaieaeia,
aeeeenoeueoiiaieaeia e iiauo ii/aaei ?yaea ii?ai?iaia. Ia iniiaaiee
aeaiiuo niaeo?aeueiuo iaoiaeia (EE- e ssI? 1I e 13N niaeo?ineiiey)
onoaiiaeaii, /oi aeey niaaeeiaiee ia?aie a?oiiu iacaaeneii io
i?eaioaoeee caianoeoaey e oeia yiieneaee?othuaai aaaioa aaeeinoaaiiuie
i?iaeoeoaie ?aaeoeee yaeythony niioaaonoaothuea yiieneaeiua
i?iecaiaeiua. Aeey yiaei-noa?aieciia?ia aeaoo iineaaeieo a?oii
ii?aaeaeaia a iiaeaaeythuai aieueoeinoaa neo/aaa no?oeoo?a i?iaeoeoia
aioo?eiieaeoey?iie oeeeeecaoeee — caiauaiiuo
yeci-2-aeae?iene-4-acao?eoeeeei[4.2.1.03,7]iiiaiia (acaa?aiaeaiia).
Yeci-noa?aieciia?u o?ainoi?ie?othony a o?eaeaeueiua yiieneaeu. N
iiiiuueth aeaiiuo oai?aoe/aneeo ?an/aoia ioeaiaiu aiciiaeiua i?e/eiu
aaoa?ioeeeeecaoeee eee aa ionoonoaey a ?yaeo eco/aiiuo niaaeeiaiee. Ia
iniiaa yiieneaeiuo i?iecaiaeiuo
N-(aoeee)-yiaei-5-aieiiiaoeeaeoeeeei[2.2.1]aaio-2-aiia ?ac?aaioai iaoiae
neioaca iiaie a?oiiu aeeee-(a?aeeee)caiauaiiuo acaa?aiaeaiia.
Inouanoaeai neioac 5-aieiiaeoeeeei[2.2.1]aaio-2-aia,
5-(2`-aieiiyoee)aeoeeeei[2.2.1]aaio-2-aia e ?ac?aaioai iaoiae neioaca
5-(3`-aieiii?iiee)aeoeeeei[2.2.1]aaio-2-aia, ia eo iniiaa a ?aaeoeeyo n
yeaeo?ioeeueiuie ?aaaaioaie ?acee/iie i?e?iaeu
(a?eenoeueoiieeoei?eaeaie, a?eeea?aiieeoei?eaeaie, ecioeeaiaoaie,
ecioeioeeaiaoaie e ae?.) iieo/aia iaoe?iay a?oiia iiauo i?iecaiaeiuo
(aieaeia, noeueoiiaieaeia, ii/aaei e ae?.), eco/aii niaeo?aeueiia
iiaaaeaiea iineaaeieo. N oeaeueth iieo/aiey iiauo aeaiiuo i i?ioaeaiee
i?ioeannia ieeneaiey a ?yaeo ?acee/iuo i?iecaiaeiuo ?yaea ii?ai?iaia
i?iaaaeaii yiieneaee?iaaiea a?oiiu iieo/aiiuo noeueoiiaieaeia e
ea?aienaieaeia n ?acee/iui oaeaeaieai caianoeoaey io ii?ai?iaiiaiai
ea?eana. Aeey anao neo/aaa n iiiiuueth niaeo?aeueiuo aeaiiuo aeieacaii
ia?aciaaiea oieueei yiieneaeiuo i?iecaiaeiuo. Iaia?oaeaia e ianoaeaeaia
iaiau/iay ia?aa?oiie?iaea a ?aaeoeee 5-aieiiaeoeeeei[2.2.1]aaio-2-aia n
i-ieo?ioaieenoeueoiieeoei?eaeii, i?eaiaeyuay e ia?aciaaieth
aaoa?ioeeeee/aneie nenoaiu ?yaea 3-acaaeoeeeei[3.2.1]ieo-6-aia.
Ii?aaeaeaiu yenia?eiaioaeueiua oneiaey, aeeythuea ia noaiaiue i?ioaeaiey
aeaiiiai i?ioeanna. Enneaaeiaaia ianoeoeeaeiay (ooiaeoeeaeiay,
ooiaenoaoe/aneay, ?ino?aaoee?othuay, aaeoa?eoeeaeiay) aeoeaiinoue a?oiiu
nieae noa?aieciia?iuo 5-aieiiiaoeeaeoeeeei[2.2.1]aaio-2-aiia, iieo/aiu
aaaeiua auaiaeu i aeeyiee no?oeoo?iuo iniaaiiinoae iieaeoe, a /anoiinoe,
noa?aioeiee caianoeoaey o aeoeeeee/aneiai ea?eana, ia neeo e oa?aeoa?
aeoeaiinoe. I?e eco/aiee oa?iaeieiae/aneie (aiaeueaaoe/aneie,
i?ioeainoaei?iaeiie, o?aieaeeece?othuae, i?ioeaiainiaeeoaeueiie,
aioeaeiiene/aneie) aeoeaiinoe ?yaea niaaeeiaiee (aieaeia,
noeueoiiaieaeia, ii/aaei) iaia?oaeaii aeeyiea ?acee/iuo oaeoi?ia (oei
caianoeoaey, aai i?eaioaoeey, oaeaeaiiinoue io aeoeeeee/aneiai ea?eana e
ae?.) ia oa?aeoa? iae?io?iiiiai aeaenoaey i?aia?aoia.

Eeth/aaua neiaa: aieiu ?yaea ii?ai?iaia, aieaeu, noeueoiiaieaeu,
ii/aaeiu, yiieneaee?iaaiea, acaa?aiaeaiu, aaoa?ioeeeeecaoeey,
aeieiae/aneay aeoeaiinoue.

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