1

I?i?noa?noai ioi?iie caei?ia y Oe?a?ie

Ee?anueea iaaee/ia aeaaeaiiy iineyaeeieiiii? ina?oe

?i. I.E. Ooieea

ssuaiei Aiae??e Ai?eniae/

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Noai IA?AIAI? NENOAIE A??iee?a, ye?

eiioaeoothoue c ieeneaie ia?aaioeth

14.01.15 — ia?aia? oai?iae

A A O I ? A O A ? A O

aeena?oaoei? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoeith ?oeiien.

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeineiaeiiio iinoeoooi
i?iieneiai? iaaeeoeeie I?i?noa?noai ioi?iie caei?iay Oe?a?ie

Iaoeiaee ea?iaiee — aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee, Iaoiaiei Ai?en Na?a?eiae/, Oe?a?inueeee
iaoeiai-aeineiaeiee iinoeooo i?iieneiai? iaaeeoeeie IIC Oe?a?ie,
caa?aeoaa/ ee?i?/iiai a?aeae?eo

Ioioeieii iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Iaiueeianueeee Ieeeoa Ai?eniae/,
?inoeooo aa?iioieia?? AII Oe?a?ie /i.Ee?a/, a?aeae?e ee?i?/ii?
o?c?ieia?? oa iaoieia?? ia?aiai? nenoaie, eiinoeueoaio a?aeae?eo

aeieoi? iaaee/ieo iaoe, i?ioani? Eenaithe A?eoi? Iaaeiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey IIC Oe?a?ie
/i.Ee?a/, eaoaae?a ?aaa?e?oaoe?eii? iaaeeoeeie, caa?aeoaa/ eaoaae?e

I?iaiaeia onoaiiaa: Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ee?i?/ii?
oa aenia?eiaioaeueii? iaa?ieia?? oa ineo?ao??? IIC Oe?a?ie /i.Oa?e?a/,
a?aeae?e iaoieia?? aaaaoaoeaii? ia?aiai? nenoaie

Caoeno aiaeaoaeaoueny » 16 » /a?aiy 1999?. i 11-00 aiaeei ia
caniaeaiii niaoeiaeiciaaiii? a/aii? ?aaee Ae 26.613.01 i?e Ee?anuee?e
iaaee/i?e aeaaeaii? iineyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie
ca aae?anith: 254112, i.Ee?a, aoe. Aei?iaiaeeoeueea, 9, aoaeeoi??y ?3.

C aeena?oaoe??th iiaeia iciaeiieoenue o aaeioaoe Ee?anueei? iaaee/ii?
aeaaeaii? iineyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie ca
aae?anith: 254112, i.Ee?a, aoe. Aei?iaiaeeoeueea, 9.

Aaoi?aoa?ao ?icineaiee » 15 » o?aaiy 1999?.

A/aiee nae?aoa?

ciaoeiaeiciaaii? a/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe, aeioeaio
I.?.?iiaiaieiCAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue oaie. Oe?a?ia caeia? ia?oa i?noea o na?o? c aeaeiaoaaiiy
ia?aaioeaaeo ?oae. I?ioean ?o aeaeiaoaaiiy oa caaaa/aiiy
noi?iaiaeaeo?oueny ?ioaineaiei ieea-ooai?aiiyi. I?e oeueiio ai?no
ieene?a ia?aaioeth (II) a ieeo, ia ?iai/eo i?noeyo i?aecaiieo a??iee?a
ia?aaioeaaeo oaoo, ia?aaeuo? a?aie/ii aeiionoei? eiioeaio?aoe?? (AAeE) a
2-50 ?ac?a (Iaea?aiei I.A. e niaao.,1979)1I?ei?oea. 1) Aeai? eaai?aoi???
Ia?aaiaoeueeiai a??ie/i-caaaa/oaaeueiiai eiia?iaoo c ioi?iie
iaaeieeoiueiai na?aaeiaeua ca 1993-1995 ?iee.). A oeeo oiiaao ?ia?oieee
ia?aaeathoueny ia iaaaciaeo ?icaeoeo ia?aaioeaai? ?ioieneeaoe??, ee?i?ea
yei? ia? i?ia?aae??ioiee ia?aa?a oa aaaeei i?aeaea?oueny e?eoaaiith
(Iaea?/aiei A.O.,1956; A?aoeeaineay E.I. e niaao., 1985; Iaeueieeiaa
I.I., 1995; Huang C.C. et al.,1997,1998). Aea a ia??iae aeoeaii?
o?oaeiai? ae?yeueiino? ?ia?oiee?a oe? ci?ie /ano?oa ianiaoeeo?/i? ?
aacothoueny ia ii?ooaii? ?aaeoeaiino? i?aai?cio, a e?ea?yie
?icoe?iththoueny ye neiioiie ?ioa?eo?aioieo caoai?thaaiue. Ia oea aeaco?
a?eueo aeniea (ia 25-60%) caoai?thaai?noue c oei/aniaith ao?aoith
i?aoeacaeaoiino? (COAI) na?aae a??iee?a ia?aaioeaai? i?iieneiaino? a
ii??aiyii? c a??ieeaie i?aei?e?inoa E?eai??cueeiai cae?ci?oaeiiai
aanaeio, aea oiiae i?aoe? iiae?ai?, e??i ae?? II (Aaiii A.A. e
niaao.,1991). Aei inoaiiueiai /ano aeyaeaiith oe??? iaoieia?? ia
i?eae?eyeinue aeinoaoiuei? oaaae. Oae iaaeeei-nioe?aeueia aenia?oia
eii?n?y (INAE), yea ianeoaiao? I?eiiieueneee ia?aaioeaaee ?aa?ii
ina?ae/o? ui??/ii a 3-4 ?ace a?eueoa ?iaae?ae?a, a no?oeoo??
caoai?thaaiiy yeeo i?enooi?e neiae?ii ia?e?inii?cio, o ii??aiyii? c
aiaeia?/iith INAE a ?aa?ii? E?eaaano. I?e oeueiio e?ea?? ia aaa/aee
iiaeeea?noue ao?ieia?/iiai aieeao II ia ii?ooaiiy aeno?ai??ai?aeii?
ia?aiai? nenoaie, ine?eueee aiie niinoa??aathoueny ia i?ci?o aoaiao
aeeooy. Iacaaaeath/e ia oea, aei inoaiiueiai /ano aea/aiiy oe???
i?iaeaie ia i?iaiaeeeinue, oi/a inai?iiy I?eiiieueneiai ia?aaioeaaiai
aannaeio (IIA) cae?enith?oueny iaeaea 100 ?ie?a.

sseui aaaaoi aniaeo?a iaoiaaiaco ? ee?i?ee ae?aaeaieo oi?i ia?aaioeaai?
?ioieneeaoe?? aeoeaii aea/aeenue, a iniiaiiio aei 80-o ?ie?a, oi ?aii?
?? i?iyae aei inoaiiueiai /ano caeeoathoueny iica oaaaith aeine?aeiee?a
(Ae?iae/eia Y.A., 1963; A?aoeeaineay E.I., 1957, 1985; ?uaeeiaa I.I.,
1976; Shinotoh H. et al., 1997; Kim J.W.et al.,1998; Nagatomo S. et al.,
1999). Ia?aaaaeii aeine?aeaeoaaeanue ae?y ia i?aai?ci aa?iciey
eiiaeainaoe?? II (Iaoeiaa A., Ea?aaeaeia E.,1991; Yeaa?aeo A.O., 1993 oa
?i.). Iia?aeiieaiiy i?i aieea aa?iciey aeac?ioaa?aoe?? — ieeo, yeee
i?noeoue a nia? II, iiiaeeiie? (Aeaeaaaoaaeca ?.Ae. e niaao., 1987). A
?aeo?n? oe??? i?iaeaie ua a 1985 ?ioe? aoei i?eeiyoi ??oaiiy aenia?o?a
Anana?oiuei? i?aai?caoe?? ioi?iie caei?iay (AIIC): “…i?iaeiaaeeoe
aeine?aeaeaiiy c i?iaeaie o?ii?/ii? ae?? ia?aaioeth ia i?aai?ci
ethaeeie, caa?ioaoe iniaeeao oaaao ia ?? ?aii? i?iyae”. Nioe?aeueia ?
iaaee/ia cia/ou?noue i?iaeaie ?aii?o i?iya?a aieeao II ia ?iai/eo
iaoiiaeea iaiao?aei?noue i?iaaaeaiiy oeeo aeine?aeaeaiue.

Caycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.
Oe?eani?yiiaai?noue ?iaioe aecia/aia o a?aeiia?aeiino? c caaaeaiiyi OeE
i?ioni?eee ?iai/eo iaoaeo?a?eii? i?ieneiaino? N?N? 05-AN a?ae 25.09.89
?., aeine?aeaeaiiy i?iaiaeeeenue ca?aeii IAe? “Eco/eoue aeeyiea ieeneia
ia?aaioea ia ninoiyiea caei?iauey ai?ii?aai/eo Ia?aaiaoeeiai AIEa” iiia?
aea?ae?a?no?aoe?? 01.900009468 (1990-1991??.) oa aea?aeathaeaeaoii? IAe?
“?ac?aaioea iaoiaeia ?aiiae aeeaaiinoeee e i?ioeeaeoeee
aeiiicieiae/aneeo ninoiyiee o?iie/aneie ia?aaioeaaie eioieneeaoeee o
ai?ii?aai/eo ia?aaiaoeaeiauaathuae i?iiuoeaiiinoe” (1993-1995??.) iiia?
aea?ae?a?no?aoe?? 01.94U029985, yea i?ieoea aaeocaaee eiieo?n IIC
Oe?a?ie.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. ?ic?iaea ? iaoeiaa iaa?oiooaaiiy
iaoiae?a ae?aaiinoeee oa iaaee/ii? i?io?eaeoeee ci?i ia?aiai? nenoaie o
a??iee?a ia?aaiaoeueaeaeiaoaii? i?iieneiaino?, ni?yiiaaieo ia
caiia?aaiiy ?icaeoeo o?ii?/iiai iaiaaiioieneeico.

A?aeiia?aeii aei iaoe aoei iinoaaeaii oae? caaaeaiiy:

— aea/eoe caaaeueio COAI o ?ia?oiee?a, caeiyoeo ia aeaeiaoaaii? oa
ia?a?iaoe? ia?aaioeaaeo ?oae;

— aeyaeoe ?aii? iaoieia?/i? aoaeoe o?ii?/ii? ae?? ieeo ia?aaioeth ia
ia?aiao nenoaio ?ia?oiee?a;

— aeine?aeeoe ii?oieia?/i? iniaeeaino? o?ii?/iiai aieeao ia?aaioeth ia
oeaio?aeueio ia?aiao nenoaio (OeIN) aenia?eiaioaeueieo oaa?ei;

— aecia/eoe iaea?eueo ?ioi?iaoeai? e?eoa??? ae?aaiinoeee
i?e?iiaiaaii-oieneeico;

— ?ic?iaeoe niin?a ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico;

— ?aeiiaiaeoaaoe aaeaeaaoi?, iaoeiai-iaa?oioiaai? iaoiaee iaaee/ii?
i?io?eaeoeee iaiaaiioieneeico.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aecia/ai? iaea?eueo
cia/ou? ee?i?ei-ooieoe?iiaeuei? iciaee ?aii?o i?iya?a iaiaaiioieneeico.
Ia ?o iniia? aeae?eai? ae?aaiinoe/i? e?eoa??? noaee?i?/ii? noaae??
iaiaaiioieneeico oa ?ic?iaeaia iaoaiaoe/ia iiaeaeue ae?aaiinoeee, yea
aeicaiey? i?iaiaeeoe eiiieaenio ioe?ieo iaoieia?/ieo ci?i. Ai?iaaoe?y
oe??? iiaeae? iieacaea ?? aoaeoeai?noue a 94% aeiaaee?a.

Aeyaeai? iaoieia?/i? aoaeoe aieeao ia?aaioeth ia i?aai?ci
aenia?eiaioaeueieo oaa?ei, ye? na?ae/aoue i?i aeano?oeoeai? oa
ia?aaaaeii iacai?ioi? ci?ie a aieiaiiio iiceo (a ee?oeiao e??ee aaeeeeo
i?aeoeue, iici/eo, ae?aei? eoe?). Aeno?aiieyoe?y oeeo ci?i ia i?aai?ci
ethaeeie aeicaieeea ?ice?eoe ie?ai? iaoiaaiaoe/i? iaoai?cie
ooieoe?iiaeueieo ii?ooaiue ia?aiai? nenoaie, ye iane?aeie noai?aiiy
aeaoa?i?iaioieo no?oeoo? ia ??cieo ??aiyo OeIN. Aiie ?icaeaathoueny a
?acoeueoao? iai?oaeaiiy iaoai?ci?a aaeaioaoe?? c ii/aoeiaeie i?iyaaie
?iceaaiaeaeaiiy iae?iae?iai?/ieo aca?iicayce?a oa iae?iaoii?aeueii?
?aaoeyoe??, ye? ?aae?cothoueny o aeaeyae? iaoieia?/ieo noaee?i?/ieo oa
ee?i?/ieo ci?i, ui aecia/athoue nooi?noue iaiaaiioieneeico.

Iaa?oioiaaia eiioeaioe?y i?io?eaeoe/ieo caoiae?a ia noaee?i?/iiio aoai?
caoai?thaaiiy, yea aeeth/a? caoiaee iai?aaeai? ia aeaaaeaiiy iaaeeeoeo
ia?aaioeth ?c i?aai?cio, ia a?aeiiaeaiiy iioeiaeaeaieo ooieoe?e.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeaiee iaeei c
iai?yieia aeey ?ica’ycaiiy aaaeeeaiai caaaeaiiy aeey caa?iaaiiy
caei?ia’y eaae?ia a ia?aaioeaa?e ai?ie/i?oaeiie i?iieneiainoi —
aeei?enoaiiy aieueo aeineiiaei? iaaee/ii? i?ioieaeoeee o?iii/ii?
ia?aaioeaai? ?ioieneeaoe??. Noai?aia nenoaia iaaee/ii? i?ioieaeoeee
iaiaaiioieneeico aeicaieeea:

— i?iaiaeeoe ae?aaiinoeeo, e?eoaaiiy oa aenia?oeco i?aoeacaeaoiino? ia
iaea?eueo ?aii?o noaae?yo iaiaaiioieneeico;

— cai?iiiioaaoe iaoiaaiaoe/ii iaa?oioiaaia e?eoaaiiy iaiaaiioieneeico oa
i?aeaeueoe eiai aoaeoeai?noue aei 72%;

— iie?aueoe aeeniaina?ia ianeoaiaoaaiiy ?ia?oiee?a, ye? ii oaoiieia??
ae?iaieoeoaa ciooai? i?aeiaaeaoe i?ae ae?th II.

I?iaaaeaiiy oeeo caoiae?a ni?eyei caa?aaeaiith i?aoeacaeaoiino? a nai?e
i?ioan?? oa cieaeaiith caoai?thaaiino? o ?ia?oiee?a ia?aaioeaaeo
?oaeiee?a ia 32% o aeiaaeeao ? 17% o aeiyo iai?aoeacaeaoiino?.
Caiia?aioo? aeiiii?/i? caeoee neeaaeathoue 881577 a?eaaiue ca ??e.

Ca iaoa?iaeaie aeena?oaoei? iaae?oeiaai? ? ai?iaaaeaeai? iaoiaee/ii
?aeiiaiaeaoei? «Aeiaaiinoeea ? iaoiaee i?ioieaeoeee ?aiiio i?iyaia
iaiaaiioieneeico», 2 aea?aeaai? iaoaioe ia aeiaoiaee. Cai?iiiiiaaii
niiniae aeiaaiinoeee oa i?ioieaeoeee o?ii?/ii? ia?aaioeaai?
?ioieneeaoe?? ai?iaaaeaeaii a ee?i?oe? Oe?a?inueeiai IAe? i?iieneiai?
iaaeeoeeie, naiaoi???-i?io?eaeoi???, oeaoia?e iie?ee?i?oe?
Ia?aaiaoeueeiai a??ie/i-caaaa/oaaeueiiai eiia?iaoo (ACEo),
iaaeeei-nai?oa?ieo /anoeiao Caii??cueeiai aethi?i??aiai eiia?iaoo,
I?eiiieueneiai caaiaeo oa??inieaa?a, Caii??cuee?e iaeani?e e?ea?i?,
i?ae?aeiii?e i?ioiaoieiai/i?e INAE i.E?eaiai ?iaa. Iaoa?iaee
aeena?oaoei? aeei?enoiaothoueny i?e /eoaiii eaeoeie i i?iaaaeaiii
i?aeoe/ieo caiyoue aeey eiea?ia-i?ioiaoieiaia a Oe?a?inueeiio IAe
i?iieneiai? iaaeeoeeie, aeey nooaeaioia eaoaae?e i?ioiaoieiai? oa
eo?naioia oaeoeueoaoo oaeineiiaeaiiy eiea?ia Aeiii?iiao?ianueei?
iaaee/ii? aeaaeaii?. Niin?a e?eoaaiiy ?aii?o i?iya?a ia?aaioeaai?
?ioieneeaoe?? aianaii a ?a?no? aaeocaaeo iiaiaaaaeaiue ca ? 98/8/8.
Aeacia aeua ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe i?aeoaa?aeaeo?oueny
a?aeiia?aeieie aeia?aeeaie oa aeoaie.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaaaeai? ee?i?/i?
aeine?aeaeaiiy, aecia/aia iaoeiaa ? iaoaioia iiaecia, naiinoieii
aeeiiaii oa noi?ioeueiaaii: iaeyae eioa?aoo?e, ?icaeiee aeanieo
aeineiaeaeaiue, aeniiaee oa i?aeoe/ii ?aeiiaiaeaoei?. Anoaiiaeai?
ii/aoeia? iciaee iaiaaiioieneeico, ?ic?iaeaia iaoaiaoe/ia iiaeaeue oa
aecia/ai? e?eoa??? ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico,
cai?iiiiiaaia nenoaia i?io?eaeoeee ?aii?o i?iya?a o?ii?/iiai
iaiaaiioieneeico. Iniaenoee aianie aaoi?a o ?iaioao, iioae?eiaaieo o
ni?aaaoi?noa? iieyaa?: [4] — iinoaiiaea caaea/?, i?iaaaeaiiy ee?i?/ieo
aeine?aeaeaiue, ia?iaea ?acoeueoao?a; [5,6] — ?ic?iaea ?aea?, aecia/aiiy
iaoaioii? iiaecie, ?ic?iaea iaoaiaoe/ii? iiaeae? ae?aaiinoeee, ee?i?/i?
aeine?aeaeaiiy; [7,8,9,10] — ee?i?/i? aeine?aeaeaiiy, aiae?c ? ia?iaea
?acoeueoao?a; [11] — noaoenoe/i? ?ic?aooiee, iaa?oiooaaiiy iniaeeainoae
caoai?thaaiino?.

Ai?iaaoeiy ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe ?iaioe
iaaiai?thaaeenue ia XII-io c’?caei a?a??i?no?a Oe?a?ie (Iaeana, 1991
?.); IV-io c’?caei ea?aeiieiaia Oe?a?ie (Aeiii?iiao?ianuee, 1993 ?.); ia
iaoeiai-i?aeoe/ieo eiioa?aioeiyo o iinoao Aeiiaoeueeo (1995?), E?eaiio
?ici (1995 ?.); iaoeiaeo eiioa?aioeiyo iieiaeeo a/aieo Oe?a?inueeiai
IAeI i?iieneiai? iaaeeoeeie oa IAe? iaaeeoeeie i?aoe? AII Oe?a?ie (1992,
1996, 1998 ??.); eiioa?aioeiyo iaoeiaiai oiaa?enoaa iaa?iiaoieia?a
i.E?eaiai ?iaa ( 1995-1998 ??.), a oaeiae ui?i/ii ia oeeeeao
oaeineiiaeaiiy eiea?ia-i?ioiaoieiaia, ia naiiia?ao aeey oeaoiaeo eiea?ia
Aeiii?iiao?ianueei?, Caii?icueei?, Ei?iaia?aaenueei? oa
Iaaii-O?aieianueei? iaeanoae.

Ioae?eaoe??. Ca iaoa?iaeaie aeena?oaoei? iaae?oeiaaii 11 iaoeiaeo ?iaio,
na?aae yeeo 3 noaoo? a aeo?iae?, 1 noaooy a ca??ieeo iaoeiaeo i?aoeue, 2
aea?aeaai? iaoaioe ia aeiaoiaee, 5 oac aeiiia?aeae ia c?caeao ?
eiioa?aioe?yo.

Ianya i no?oeoo?a aeena?oaoei?. Aeena?oaoeiy aeeeaaeaia ia 163 noi?iieao
iaoeiiieniiai oaenoo i neeaaeaoueny c anooio, aiaeioe/iiai iaeyaeo
eioa?aoo?e, 6 ?icaeieia aeanieo aeineiaeaeaiue, aiae?co oa ocaaaeueiaiiy
?acoeueoao?a aeine?aeaeaiue, aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoeie,
nieneo aeei?enoaii? e?oa?aoo?e i aeiaeaoeia. ?iaioa aeeth/a? 29
oaaeeoeue ia 31 noi??ioe?, 13 iaethieia ia 13 noi??ieao, 3 aeiaeaoee ia
5 noi??ieao. Aiaeiia?aoi/iee aeaciaiee i?noeoue 165 iaoeiaeo i?aoeue ia
17 noi??ieao.

CINO ?IAIOE

Iaoa?iaee i iaoiaee aeineiaeaeaiiy. ?acoeueoaoe ?iaioe aacothoueny ia
aeaieo ianoaaeaiiy a oiiaao eeiiiee Oe?a?inueeiai IAe i?iieneiai?
iaaeeoeeie 103 noaaeiaaieo ai?ieeia ia?aaioeaaeo oaoo (iniiaia a?oia)
oa 34 ?iaioiee?a cae?ci?oaeieo oaoo (eiio?ieueia a?oia), oiiae i?aoe?
yeeo noiae?, ca aeiyoeii ae?? II. Ani ianoaaeaii aoee /ieiai/i? noaoi.
A?oie ?iaioieeia nooo?ai ia a?ae??ciyeenue ca aieiaei oa noaaeaaei
neeaaeii. An? ianoaaeai? aoee ?icaeieaii ia aea? noaaeia? i?aea?oie:
1-oa — aei 15 ?ie?a i?aoe?, 2-aa — 15 ?ie?a ? a?eueoa.

Ii?yae c caaaeueiii?eeiyoeie eeiii/ieie i eaai?aoi?ieie iaoiaeaie
aeine?aeaeaiiy (iaa?ieia?/iee iaeyae, caaaeueiee aiaeic e?iai, na/? oa
?i.) aoee aeei?enoaii a?io?i?/i?: aecia/aiiy aeiaiai? aene?aoe??
eaoaoieai?i?a, ai?noo a e?ia? aoeao?eoie?io, aeoeaiino?
aoeao?eoie?ianoa?ace, ai?noo ia?aaioeth a a?inoano?aoao;
iino?oiaioaeueii: aecia/aiiy aieueiai?, a?a?aoe?eii? /ooeeaino?,
oaiia?aoo?e oe??e, aeaeo?ii?ia?o?y, eii?aeeiiiao??y, ?aiaacia?ao?y,
i?ioiiiiao??y; ineoieia?/i?: ianoaaeaiiy ca iaoiaeeeith aaaaoia?/iiai
ianoaaeaiiy iniaenoino? (IAII), aecia/aiiy ianyao iaiyo? oa oaaae;
iaoaiaoeei-noaoenoe/ii iaoiaee.

Aeey aecia/aiiy caeaaeiino? noaio neiiaoi-aae?aiaeiai? ? oie?ia?a?/ii?
nenoai a?ae ?ioaineaiino? ae?? ia?aaioeth, ianoaaeai? iniiaii? a?oie
aoee ?iciiae?eai? ia i?aea?oie ca eiioeaio?aoe?yie II a ieeo ia ?iai/eo
i?noeyo — 5,9-16,3 ia/i3 ? 0,4-2,8 ia/i3.

Aeey aea/aiiy aoaeoeaiino? i?ioieaeoe/iiai e?eoaaiiy 42 iaoe??ioa c
noaee?i?/iith noaae??th o?ii?/ii? ia?aaioeaai? ?ioieneeaoe?? aoee
ianoaaeai? aei i iiney eieoaaiiy, na?aae ieo 12 iaoe??io?a io?eioaaee
cai?noue e?e?a ieaoeaai.

Aea/aiiy COAI i?iaiaeeeinue c aeeiiithaaiiyi eiea?iyieo eenoeia ?
iaeieiaeo iniaenoeo ea?o oa ii oi?iai 16-AI na?aae ?iaioieeia
i?aei?e?inoa Ia?aaiaoeueeiai ACEo i?noa Ia?aaiaoeue, ae?iaie/iai
ia?aeiaiiy “E?eaaan?oaea”, ?iaoeaoeueeiai ACEo iinoa E?eaiai ?iao c 1986
aei 1996 ?ieo. Ca aeaieie INAE I?eiiieuenueeiai ?aeiio ? Naenaaainueei?
INAE i.E?eaiai ?iao aiae?coaaeenue iieacieee ?iaae?aeiino? c iayai?noth
a no?oeoo?? caoai?thaaiiy neiae?iio ia?e?inii?cio.

Ii?oieia?/i? aeine?aeaeaiiy i?iaiaeeeenue ia 12 iaoetheao, yeei ia
i?ioyc? 70 ae?a /a?ac oeoiie aaiaeeee oei?eae ia?aaioeth a aeic? 20 ia
ia e?eia?ai aaae. Ca eiio?ieueio a?oio aoee 6 iaoethe?a, yeei aaiaeeee
aea?iiey?i? aeice ?cioii?/iiai ?ic/eio iao??th oei?eaeo. I?iaaaeaia
iioe/ia oa aeaeo?iiia i?e?ineii?y i?aia?ao?a aieiaiiai iiceo
oaa?ei.1I?ei?oea.

1) Ii?oieia?/i? aeine?aeaeaiiy i?iaiaeeeenue ni?eueii c e.i.i.
N.I.Eoaianueeei.)

Aeey ?ic?iaee iaoaiaoe/ii? iiaeae? aeiaaiinoeee o?ii?/ii? ia?aaioeaai?
?ioieneeaoe?? aoee noai?aii aace aeaieo aeineiaeaeaiue, ye? ia?iaeaii ia
AII AI ?N /486/ c aeei?enoaiiyi iaoiaeo iaoiiao?e/iiai aeai?eoio ca
i?ia?aiith ?ic?iaeaiith a nenoai? FOXPRO/LAN2.0 oa iaoiae?a aa?iaoeieii?
noaoenoeee (A.N.Aaian, 1968; A.A.Aoaea?, 1990).

Iniiaia ?aeay ?iaioe iieyaa? a ae?aaiinoe/i?e aa??o?eaoe?? ?aii?o ci?i
ia?aiai? nenoaie i?ae aieeaii II oa ?o ei?aeoe?? aeey ia iie?ioaiiy
noaio caei?iay ?iai/eo oa iiia?aaeaeaiiy ?icaeoeo ia?aaioeaai?
aioeaoaeiiao??.

?acoeueoaoe aeineiaeaeaiue. Aeey aea/aiiy no?oeoo?e iaoieia?/ieo aoaeo?a
ae?? ia?aaioeth ia ??ci? nenoaie i?aai?cio ethaeeie i?iaaaeaiee aiae?c
COAI. Anoaiiaeaii, ui ??ai? CAOI ?ia?oiee?a ia?aaioeaaeo i?aei?e?inoa ia
60% a aeiaaeeao iai?aoeacaeaoiino?, 25-40% a aeiyo aeinoia??ii aeua i?ae
o ?ia?oiee?a cae?ci?oaeieo i?aei?e?inoa (?0,05).

I?e ii??aiyii? COAI ca iicieia?/ieie eeanaie aeyaeaii i?aeaeuaiiy ??aiae
COAI o a??iee?a, ye? eiioaeoothoue c II ca?aeii eeanai oai?ia: aa?oi?o
aeeoaeueieo oeyo?a, e?noeiai-iyciai? nenoaie, ia?aiai? nenoaie ?
ia?eoa?e/ieo aaiae??a, caoai?thaaiiyi i/ae, oe??e a 2-5 ?ac?a a
aeiaaeeao, a 1,5-4 ?ace a aeiyo iai?aoeacaeaoiino?. Io?eiai?
?acoeueoaoe ca?aathoueny c aeaieie Oaeae?ia TH.I. (1990), yeee
niinoa??aaa a no?oeoo?? caoai?thaaiueino? o ?ia?oiee?a, caeiyoeo ia
ae?iaieoeoa? iai?aai?/ieo nieae ia?aaioeth, e??i na?oeaai-noaeeiieo
oai?ia, ia?aaaaeio a?eueo?noue oaeeo aea caoai?thaaiue. A i?aeaeuaii?
COAI a?aeia?aaeai? ie?ai? aniaeoe iie?o?iiii? ae?? ia?aaioeth —
iae?io?iiiee, iiae?acithaaeueiee, ?ioiiaeai?aneaiee.

Anoaiiaeaii i?aeaeuaiiy ??aiy COAI a 1,5 — 2,0 ?aca na?aae noaaeiaaieo
a??iee?a. A?eueo aenie? ??ai? caoai?thaaiino? a?aecia/aeenue i?e
a?eueoeo eiioeaio?aoe?yo ia?aaioeaaiai ieeo (?0,05).

Aeyaeaii cia/ia i?aeaeuaiiy (a 3,5-4 ?ace) iieaciee?a ?iaae?aeiino?,
iiaycaiii? c oai?iaaie, aei neeaaeo yeeo aoiaeeoue neiae?ii Ia?e?iniia,
o ianaeaiey, yea aeeaa a ?aa?ii? IIA, a ii??aiyii? c ianaeaiiyi
cae?ci?oaeiiai i?iieneiaiai ?aa?iio(?0,05).

A oeieiio, ?acoeueoaoe i?iaaaeaieo aeineiaeaeaiue c aea/aiiy COAI oa
iiaae?aeiino? na?ae/aoue i?i aieea II ia noai caei?iay ?ia?oiee?a
no/aniiai ia?aaioeaaiai ae?iaieoeoaa oa i?i a?eueo /ano?oa aeieeiaiiy
iaoieia?? aeno?ai??ai?aeii? ia?aiai? nenoaie a iioeeiio a?oe? o
ianaeaiiy ia?aaioeaaiai i?iieneiaiai ?aa?iio.

Aeey aea/aiiy iniaeeainoae ae?? niieo/aiue ia?aaioeth ia oeaio?aeueio
ia?aiao nenoaio aoee i?iaaaeai? ii?oieia?/i? aeine?aeaeaiiy aieiaiiai
iiceo iaoethe?a, ye? caciaaaee o?ii?/ii? ae?? ia?aaioeth. Anoaiiaeaii,
ui ia?aaiaoeue aeeeeea? ?yae aeano?oeoeaieo ci?i a ei?? aieiaiiai iiceo,
iici/eo ? ae?ae?e eoe?, a?eueo?noue yeeo iaee oyaeeee ? iacai?ioi?e
oa?aeoa? (aioo??oiueiee?oeiiee iaa?ye, ia?oe?aeuei? aioo??oiueiee?oeii?
iae?ice). Oaeiae ?a?no?oaaeenue ae?aaeai? oeueo?ano?oeoo?i? ia?aaoaeiae
ia?aiaeo ee?oei: ia?oe?aeuei? iae?ice, aeeneiiieaenaoe?y ?
aeaci?aai?caoe?y e??no a i?oioiiae??yo, ianiaa ooai?aiiy a o?e? ?
a?ae?inoeao iae?ii?a i??e?iiiiae?aieo o?eaoeue, ci?ie no?oeoo?e
i??e?iiaeo aieieii. I??e?iiiiae?ai? no?oeoo?e ?icaeyaeathoueny a
e?oa?aoo??, ye i?iaeoeo aeaaaia?aoe?? ee?oeiieo i?aaiae, cie?aia
i?oioiiae??e. Aaeeea e?euee?noue oeeo no?oeoo? na?ae/eoue i?i ??cea
c?inoaiiy ?ioaineaiino? eaoaaie?/ieo i?ioean?a a ee?oeiao (Aiaieaiia
I.I., 1979), eiia??ii, oea iiaycaii c ooee?caoe??th iaaeeeoea ia?aaioeth
? i?iaeoeo?a eiai iai?io a iae?iiao aeacaieo ia?aiaeo no?oeoo?.

I?e eiiieaeniiio noaoe?iia?iiio ianoaaeaii? noaaeiaaieo a??iee?a
anoaiiaeaii, ui o?ii?/iee aieea II ia i?aai?ci ethaeeie a
eiioeaio?aoe?yo 0,4-16 ia/i3 iaoiiaeth? ?icaeoie iaoieia?/ieo aoaeo?a c
aieo ia?aiai? nenoaie. Aiie i?iyaeythoueny o aeaeyae? nea?a ia aieiaiee
a?eue (388%; 486%)I?ei?oea.

) ooo ? aeae? aeey aeaieo a noaaeaaeo i?aea?oiao: ia?oa /enei — c?
noaaeai aei 15 ?ie?a, ae?oaa — 15 ?ie?a ? a?eueoa.) caaaeueio neaae?noue
(438%; 626%), i?aeaeuaio noiiethaai?noue (438%; 546%), ci?oi?e?noue
(438%; 596%), ae?ao?aeea?noue (438%; 546%), cieaeaiiy iaiyo? (156%;
336%). ?icaeoie anoai?caoe?? i?aeoaa?aeaeo?oueny aeaieie
ineoiooieoe?iiaeueieo aeine?aeaeaiue — cieaeaiiyi ianyao iia?aoeaii?
iaiyo?, oaaae, oiia?eueiaiiyi ?ooeeaino? ia?aiaeo i?ioean?a (?0,05). O
a??iee?a iniiaii? a?oiie, ca?aeii oanoo IAII, aecia/aany i?e
ineoieia?/iiai i?io?eth ca ia?oith oeaeith (90,7±2,1;91,7±1,7 O-aae?a) c
i?aeaeuaiiyi ca oeaeaie 2-ith (73.51.8;75.31.3 O-aae?a), 7-ith
(73.21.4;78.61.2 O-aae?a), 8-ith (76.80.9; 76.41.6 O-aae?a) (?0,05). Oe?
ci?ie aeacothoue ia iayai?noue ae?aaeaiii? niiaoecaoe?? o?eaiae ia oii?
aeai?aneaieo yaeu c ianei?ciii, ia??oo/?noth, aioo??oiueith iai?oaith.
Ineoiaiioe?ei? ?iceaaee cyaeythoueny aaea i?e noaae? aei 15 ?ie?a ?
iaei ci?iththoueny i?e eiai c?inoaii?. Aeyaeai? ci?ie ineo?/ii? noa?e
ocaiaeaeothoueny c aeaieie Ieaoiiiaa A.A. (1975, 1978, 1982), yeee
a?aecia/aa iiae?ai? ci?ie ineoieia?/iiai i?io?eth i?e o?ii?/i?e
ia?aaioeaa?e ?ioieneeaoe?? o caa?iee?a.

A iniiai?e a?oii? cia/ii /ano?oa (?<0,05) ?a?no?oaaeenue neiioiie: ci?ie a /a?aiii-iiceia?e ?iia?aaoe?? (437%;376%), iiyaa i?aee??eiaeo ?aoeaen?a (53%;256%), a?iii?i?y (156%;255%), ii?ooaiiy iinoo?aeueieo ?aoeaen?a (156%;245%), iiaeaaaeaiiy nooiaeeeueii-ia??inoaeueieo ?aoeaen?a (256%;276%), ae?noii?y iyc?a (84%;245%), a?iioii?y iyc?a (32%;225%), o?aii? ?oe (508%;626%), iioeooaaiiy a iic? ?iiaa?aa (508%;336%), no?eeee /a?aiiee aea?iia?ao?ci (558%;656%), a?aae?e?iac?y ca i?iaith Aaeiooiea (0+2%;225%), caaaeueiee a?ia?a?ae?ic (104%;296%). I?e o?eaae?e ae?? II (a?eueoa 15 ?ie?a) a n?aaeiueiio ia 19-22% c?inoa? /anoioa aeyaeaiiy i?aee??eiaeo ?aoeaen?a, a?iii?i??, iyciai? ae?noii?? ? a?iioii??, a?aae?e?iac??, caaaeueiiai a?ia?a?ae?ica (? 0.05), ui aeaco? ia ?icaeoie ii?ooaiue c aieo aeno?ai??ai?aeii? ia?aiai? nenoaie. Na?aae i?aee??eiaeo ?aoeaen?a /ano?oa ?a?no?oaaeenue neiioiie i?aeai??aeiuei? a?oie (74% a?ae on?o aeiaaee?a) - aoai-i?aeai??aei?e Ia?aooiae/a, aeieiiii-i?aeai??aei?e Ia??ianeo-?aaeiae/?, i?aeai??aei?e ?aoeaen Aaoo??ueiaa, ?io? 26% - oia?oeia? ?aoeaene. Oea aeaco? ia iaio o?aceea? ii?ooaiiy ia?aiai? nenoaie, oiio ui o?eiaaiaoe/ii iieiaeoeie ? i?aee??eia? ?aoeaene i?aeai??aeiuei? a?oie, a noa??oeie - oia?oeiai?, C o?aooaaiiyi ?icaeoeo anoai?caoe??, iiyao i?aee??eiaeo ?aoeaen?a iiaeia oeoia/eoe ye iane?aeie ciaioaiiy aaeuei?aiiai aieeao ei?e aaeeeeo i?aeoeue ? ?aniianthaeaeaiiy caoaeaeaiiy a i?aee??eiaeo no?oeoo?ao ca ?aooiie o?iiiino? ia?aaioeth aei ieo. Ci?ie ia?aiai-iyciaiai aia?aoo aeine?aeaeoaaeenue ca aeiiiiiaith i?ioiiiiao??? oa aeaeo?ii?ia?ao??. Niinoa??aaeinue cieaeaiiy iyciaiai oiiono, a?eueoa ae?aaeaia a iycao ?oe. A?iaeaeo?e/i? iciaee aeno?ai??ai?aeii? iaaeinoaoiino? c?inoaee c? ca?eueoaiiyi ia??iaeo ae?? ia?aaioeth, oa /anoi ia noi?iaiaeaeoaaeenue /?oeeie ee?i?/ieie i?iyaaie (?<0,05). E??i oiai niinoa??aaeenue noaee?i?/i? ii?ooaiiy eii?aeeiaoe?? ?oo?a: a ii??aiyii? c eiio?ieueiith a?oiith aeinoia??ii ca?eueooaaany iieaciee nooiaith aeeneii?aeeiaoe?? ?oo?a, o?eaae?noue iaeiiai aeioeeo (?0.05), i?e ca?eueoaii? noaaeo c?inoaa /an i?ioiaeaeaiiy oanoo, /an oa e?euee?noue aeioee?a, /anoioa o?aii?o (?0.05). Ca?a?no?iaaii ciaioaiiy aieueiai?, a?a?aoe?eii? /ooeeaino?, oaiia?aoo?e oe??e e?ioe?aie, ye a iniiai?e, oae ? a eiio?ieuei?e a?oi?, ca?eueoaiiy ii?iao aieueiai? /ooeeaino? ia 0,1-0,2 ii (?<0,05) c? ca?eueoaiiyi noaaeo a iniiai?e a?oi?. Oe? naini?i? ii?ooaiiy, iaoiiaeai? iie?iaa??oe/ieie ci?iaie, ye iane?aeie ae?? oe?aeeeaeo oaeoi??a ae?iaie/iai na?aaeiaeua: a eiio?ieuei?e a?oi? - a?a?aoe??, iyciaiai ia?aaaioaaeaiiy, a iniiai?e - ia aeiaeaoie ua ? II. Caaaeueia ooieoe?iiaeueia iaaeinoaoi?noue ia?aiai? nenoaie ciaeoea a?aeia?aaeaiiy a noai? noaeeiii? nenoaie: niinoa??aaeenue cieaeaiiy /anoioe na?oeaaeo nei?i/aiue, ?iaeaeno Ea?aei, ca?eueoaiiy /ano aiae?ioe ia ?AA i?eaeecii ia 20% (c 0,14 aei 0,17n ) ? ia ?AA noaeei ieaei?o e?ioe?aie ia 20-30% (c 0,10 aei 0,12-0,13n), iaeii/anii c oeei ia? i?noea ca?eueoaiiiy ?aia?ao?/iiai ?iaeaeno oea?aa?aeueieo noaeei aei 0,195-0,198 Ii ? ciaioaiiy /ano eaoae?ioe (?0,05). Oe? aeai? na?ae/aoue i?i i?aeaeuaiiy oiiono a?oa??aeueieo noaeei ? ca?eueoaiiy e?iaiiaiiaiaiiy. Iiae?ai? ci?ie o aeaeo?icaa?iee?a oai?eo ia iaiaaiioieneeic niinoa??aaee Eaaiianueea I.I.(1970), Caieaae/ ?.N. (1974). ?aaeoe?y noaeei, aaaaoeo ia iyciaee oa?, aeicaiey? aaa/aoe aieea ia noaeeie iae?iiaae?aoi??a neiiaoi-aae?aiaeiai? nenoaie (NAN). Aeine?aeaeaiiy aeiaiai? aene?aoe?? eaoaoieai?i?a, iieacaei ui o a??iee?a iniiaii? a?oie i?e noaae? aei 15 ?ie?a ia? i?noea ca?eueoaiiy aene?aoe?? aae?aiae?io, a i?e noaae? a?eoa 15 ?ie?a oaeiae ii?aae?aiae?io ? aeioai?io (?0,05). I?aeaeuaiiy aene?aoe?? AeIOA ? aeioai?io niinoa??aa?oueny i?e ca?eueoaii? aeniiceoe?? II a?eueoa 15 ?ie?a (?0,05). Ia?aeeaeueii c? ci?iaie eaoaoieai?i?a ci?iththoueny iieacieee oie?ia?a?/ii? nenoaie (ON) - o ianoaaeaieo iniiaii? a?oie a?eueoa i?ae a 2 ?ace ca?eueoo?oueny ai?no aoeao?eoieeio a e?ia? (?0,01), ii?yae c oeei ciaioo?oueny aeoeai?noue aoeao?eoie?ianoa?ace (?0,05). Ca?eueoaiiy aene?aoeee eaoaoieai?i?a i?ae aieeaii II na?ae/eoue i?i iai?oaeaiiy iaoai?ci?a aaeaioaoe??. Ci?ie ni?aa?aeiioaiiy iaae?aoi??a oie?ia?a?/ii? nenoaie i?aeoaa?aeaeothoue aeai? i?i aioeoie?iynoa?acio aeoeai?noue ia?aaioeth, ca?a?no?iaai? a aenia?eiaio? ia oaa?eiao ? ?cieueiaaieo i?aaiao (Ieoaeeia A.A., 1971). Aeey aeine?aeaeaiiy aeeiai?ee ci?i NAN e ON aoa i?iaaaeaioee ?aa?an?eiee aiae?c ?o caeaaeiino? a?ae o?eaaeino? ? ?ioaineaiino? ae?? ia?aaioeth. Ca?aeii ia/eneaieo ?aa?an?eieo iiaeaeae ioe?ithaaee ci?ie iieaciee?a aeioai?ia, AeIOA, aoeao?eoie?ia, aoeao?eoie?ianoa?ace. Anoaiiaeaii, ui i?e ae?? ia?aaioeth a eiioeaio?aoe?yo 5,9-16,3 ia/i3 ?aaeoe?? aeniaaeaiiy a NAN ? ON ?icaeaathoueny ia 7-9 ?ie?a ?ai?oa, i?ae i?e ae?? II a eiioeaio?aoe?yo 0,4-2,8ia/i3. E??i oiai ON ?ai?oa, /ei NAN, ?aaao? ia ae?th ia?aaioeth: i?eaeecii ia 10 ?ie?a i?e ae?? a?eueoeo eiioeaio?aoe?e ia?aaioeth, ia 5-6 ?ie?a - i?e ae?? iaioeo eiioeaio?aoe?e. Oaeiae niinoa??aa?oueny ia??iae: a?aeiia?aeii c 15 aei 26 ?ie?a ? c 24 aei 32 ?ie?a ae?? II, eiee ia? i?noea ca?eueoaiiy aoeao?eoie?io ? eaoaoieai?i?a. Ioaea a oeae ia??iae ne?ae i/?eoaaoe c?inoaiiy iaoieia?? c aieo aaaaoaoeaii? ia?aiai? nenoaie. I?e ae?? a?eueoeo eiioeaio?aoe?e II iaeneiaeueia c?inoaiiy oe??? iaoieia?? niinoa??aaeiny aaea i?ney 13 ?ie?a noaaeo, a i?e ae?? iaioeo - i?ney 21 ?ieo noaaeo (?<0,02). I?e aeine?aeaeaii? a?inoano?ao?a aeyaeaii iaioee ai?no ia?aaioeth a e?ia? ianoaaeaieo iniiaii? a?oie 1,10-1,25 ieiieue/e ii??aiyii c eiio?ieueiith a?oiith 1,83-1,85 ieiieue/e (?0,01), oa iacia/ia ca?eueoaiiy aene?aoe?? ia?aaioeth c na/ath i?e c?inoaii? noaaeo a?eueoa 15 ?ie?a (?0,05). Aecia/aii a 1,5-3,4 ?aca a?eueoee ai?no ia?aaioeth a aieinn? ianoaaeaieo iniiaii? a?oie (?0,05), a oaeiae iii?oia eiai c?inoaiiy (a 2,3 ?aca (?0,001)) c? ca?eueoaiiyi noaaeo. Oea iiaea aooe aeei?enoaii aeey ?iaeeeaoe?? iaeiie/aiiy ia?aaioeth a i?aai?ci? ethaeeie ? oanooaaiiy aeniiceoe?? ae?? II. Na?aae ianoaaeaieo a??iee?a, ui o?eaaeee /an eiioaeooaaee c II, aeyaeaii 64 iniae c ii/aoeiaeie ci?iaie, ye? oi?iothoue ?aii? i?iyae o?ii?/ii? ia?aaioeaai? ?ioieneeaoe??. Oe? ci?ie i?iyaeythoueny ?icaeoeii iaa?iciiiae?aiiai noaio (69,6%-93,5%)I?ei?oea. ) ooo ? aeae? a aacaoe?: aeia??/? ?ioa?aaee c aeinoia??i?noth ?<0,05. ) , yeee noi?iaiaeaeo?oueny aeaiaioaie niiaoeciaaii? aeai?ann??, o?eaiaeiino?, anoai?caoe?? ia oii? iacia/iiai cieaeaiiy iianoe/ii? ooieoe??, aeayeiai oiia?eueiaiiy ?ooeeaino? ia?aiaeo i?ioean?a. Iacia/i? ?iceaaee eii?aeeiaoe?? ?oo?a aeyaeythoueny o?eueee ca aeiiiiiaith eii?aeeiiiao??? a 39,3%-71,2% aeiaaee?a. Iaaeinoaoi?noue aeno?ai??ai?aeii? ia?aiai? nenoaie i?iyaey?oueny ii?ooaiiyi a?iaeaeo?e/ii? aeoeaiino? iyc?a (53,7%-83,2%) ia?aaaaeii aac ee?i?/ieo i?iya?a. A 22,2%-53,2% aeiaaee?a niioa??aathoueny ie?ai?, iacia/ii ae?aaeai? ia?eoeai? neiioiie o?aaeaiiy ia?aiai? nenoaie, ye?, ye i?aaeei, aeyaeythoueny ca aeiiiiiaith niaoe?aeueieo i?ia. ?iceaaeiaiiy iae?iaoii?aeueieo ?aaoeyoi?ieo iaoai?ci?a iaoiiaeth? iacia/io ia?aneiiaoeeioii?th (42,0%-73,7%) ? aaiiae?iai?/i? ci?ie ii oeio aeenoii?? noaeei c ia?aaaaith a?oa??iniacio (36,6%-68,6%). Aiane?aeie o?ii?/ii? ae?? ia?aaioeth aecia/athoueny ci?ie iai?io eaoaoieai?i?a (19,1%-49,3%) oa aoeao?eoie?io (26,3%-57,9%). Niinoa??aa?oueny i?aeaeuaiiy ai?noo ia?aaioeth o aieinn? a?eueoa 3ia% (95,5%-100,0%). Neiioiiaoeea noaee?i?/ii? noaae?? iaiaaiioieneeico ia /?oea, ii noo? aiia aeeae/a aei iiiyooy “i?ioan?ei? noeaie”, ? oiio oa?aeoa?eco?oueny i?i?iaeueieie ci?iaie c aieo ia?aiai? nenoaie, ye? ia??aeei aeyaeythoueny o?eueee ca aeiiiiiaith ?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy. Oeae aeniiaie ocaiaeaeo?oueny c aeoieith ?ioeo aeine?aeiee?a (A?aoeeaineay E.I., 1957; Oaeaeei TH.I. e niaao.1973; Iaeueieeiaa I.I., 1995; Kafritsa Y. et al., 1998; oa ?i.). A?eueo?noue neiioii?a ? a?aeiinii niaoeeo?/ieie /e ianiaoeeo?/ieie, yeui ?o ?icaeyaeaoe ie?aii. O?eueee a eiiieaen? oe? ii?ooaiiy iaaoaathoue niaoeeo?/iiai oa?aeoa?o. Oiio eiiieaen ci?i ioe?ithaaee e?euee?nii ca aeiiiiiaith ?iia??iinoiiai iaoaiaoe/iiai iaoiaeo - iaoiiao?e/iiai aeai?eoio. ?ic?iaeaia iaoaiaoe/ia iiaeaeue ia/enethaaeueii? ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico iieyaa? o eiiieaeni?e ioe?ioe? iaoieia?/ii? neiioiiaoeee. Aeey oeueiai anoaiiaeai? iaea?eueo ?ioi?iaoeai? aeey ae?aaiinoeee ee?i?/i? ? noaee?i?/i? neiioiie oa aecia/ai? a?aeiia?aei? ?i ae?aaiinoe/i? aaee. Aeey aeyaeaiiy in?a c i?aeic?ith ia i?e?iiaiaaiioieneeic i?e aiaoeaoi?iiio ianoaaeaii? a?ae?a?ai? oae? neiioiie, aecia/aiiy yeeo iiaeeeaa aac canoinoaaiiy aeiaeaoeiaeo iaoiae?a ianoaaeaiiy i?e iaa?ieia?/iiio iaeyae? (a aeoaeeao ae?aaiinoe/i? aaee i?e iayaiino? oa a?aenooiino? neiioiia a?aeiia?aeii): ianenoaii? caiaii?i/aiiy(+2,-1), ii?ooaiiy nio (+2,-1), caaaeueia neaae?noue (+2,0), cieaeaiiy iai’yo? (+2,-1), caaaeueiee a?ia?a?ae?ic (+1,-1), caoa?iiaiiy e?ioe?aie (+1,0), ae?ao?aeea?noue (+1,0), i?eoiaaia a?aae?e?iac?y (+3,0), ii?ooaiiy ni?aae?oaei?o ?oo?a ?oe (+3,0), a?iii?i?y (+2,-1), i?aee??eia? ?aoeaene (+2, 0), o?aii? iaeueoe?a ?oe (+1,0), ii?ooaiiy oiiono i’yc?a (+1, -1), ci?ie /a?aaieo ?aoeaen?a (+1,-1), no?eeee /a?aiiee aea?iia?ao?ci (+1,-1). I?ney ianoaaeaiiy iaoe??ioa neeaaeathoueny ae?aaiinoe/i? aaee, a?aeiia?aei? aeyaeaiei neiioiiai, ? i?e noi? +7, /e a?eueoa, iiaeia ia?aaeaa/aoe eiia??i?noue i?e?iiaiaaiioieneeico. Oaeiio iaoe??oo iaiao?aeii i?iaiaeeoe a?eueo aeeaiea ianoaaeaiiy, aaaeaii a noaoe?iia??, ca?aeii e?eoa???a ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico. Aeey inoaoi/ii? ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico anoaiiaeai? oae? iciaee (oaae.): ci?ie ai?noo ia?aaioeth a aieinn? (ae?aaiinoe/ia ?ioi?iaoeai?noue neiioiia aei??aith? 3,261), ii?ooaiiy eii?aeeiaoe?? ?oo?a (1,529), /anoioa o?aii?o i?e aeeiiaii? oanoa eii?aeeiiiao??? (1,440), ia?aneiiaoeeioii?y ii ?iaeaeno Ea?aei (1,292), ii?ooaiiy iinoo?aeueieo ?aoeaen?a (0,556), iiyaa ?aoeaen?a i?aeueiiai aaoiiaoecio (0,556). Oaaeeoey E?eoa??? ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico (a ae?aaiinoe/ieo aaeao)IieacieeeA?aaeaoe??AaeeAi?no ia?aaioeth o aieinn?, ia%6, 0 ? a?eueoa+3a?ae 3, 0 aei 6,0- 2iaioa 3,0- 5Ii?ooaiiy eii?aeeiaoe?? ?oo?a?+3iaia? 0*anoioa o?aii?o i?e aeeiiaii?1,1 ? a?eueoa+2oanoo, a Aa?oeaoiaioa 1,1- 1Ii?ooaiiy iinoo?aeueieo?+3?aoeaen?aiaia? 0I?aee??eia? ?aoeaene?+2iaia? 0?iaeaen Ea?aei- 19 ? iaioa+2a?eueoa - 19- 1 I?e iayaiino? aai a?aenooiueino? o ianoaaeaiiiai aeacaieo neiioii?a, noiiothoueny a?aeiia?aei? ae?aaiinoe/i? aaee ? i?e aeinyaiaii? ae?aaiinoe/iiai ii?iaa +9 onoaiiaeth?oueny ae?aaiic noaee?i?/ii? noaae?? iaiaaiioieneeico. Oeae ae?aaiinoe/iee ii??a caaacia/o? oai?aoe/io 98%-ao eiia??i?noue anoaiiaeaiiy i?aaeeueiiai ae?aaiico. I?iaaaeaia ai?iaaoe?y ?ic?iaeaiiai iaoiaea ia i?aeoeoe? iieacaea, ui aii??e/ia eiia??i?noue iiieeee aei??aith? 6%, a niin?a ae?aaiinoeee ia? 94% aoaeoeai?noue oa iiaea aeei?enoiaoaaoeny ia i?ioiaeyaeao, aiaoeaoi?iiio i?eeii? ? a niaoe?ae?ciaai?e ee?i?oe?, a oiio /ene? ?c canoinoaaiiyi AII. Aaaeeeaa i?noea a iaoiaaiac? ??cieo ao?ieia?/ieo oi?i ia?e?inii?cio caeiathoue ii?ooaiiy iai?io eaoaoieai?i?a (Iaiueeianeee I.A. e niaao., 1982). I?e ia?aaioeaaiio ia?e?inii?ci? niinoa??aa?oueny cieaeaiiy aene?aoe?? c na/ath aeioai?io (?uaeeiaa I.I., Oa?aniaa E.A., 1975). E?eaeaiianueeee A.I.(1990) a?aecia/aa ianoa/o /e iaaoaeoeai?noue ae?? aeioai?ia, ye i?ia?aeiee iaoai?ci ia?e?inii?/iiai neiae?iio na?aae neeaaeiiai eiiieaeno iae?io?i?/ieo ci?i: ae?naaeaino na?ioii?io, aoeao?eoie?io, aaiia-ai?iiianeyii? eeneioe (AAIE), aeooaiaoo oa ?ioeo iae?iiaae?aoi??a ? iae?iiiaeoeyoi??a. No?oeoo?i? oa ooieoe?iiaeuei? ci?ie ia?aiai? nenoaie ia?ic?eaii iiaycai? i?ae niaith (Na?eenia Ae.N., 1990). C?noaaeaiiy io?eiaieo ii?oieia?/ieo aeaieo (no?oeoo?i? ci?ie c i?aeaeuaiiyi eaoaaie?/ieo i?ioean?a o iae?iiao, ii?ooaiiy i?ia?aeiino? ia?aiaeo aieieii oa ?i.) c o?aaeaiiyi ia?aiai? nenoaie ethaeeie i?ae aieeaii II (anoai?caoe??th, oiia?eueiaiiyi ?ooeeaino? ia?aiaeo i?ioean?a, cieaeaiiyi iianoe/ii? ooieoe??, ianyao oaaae, ?icaeoeii iaa?iciiiae?aiiai noaio, iiyaith ie?aieo i?e?iciae?a aeno?ai??ai?aeii? iaaeinoaoiueino?, ii?ooaiiy eii?aeeiaoe?? ?oo?a, a?io?i?/ieie ci?iaie oa ?i.) aeicaiey? i?eionoeoe, ui a iniia? oeeo ci?i eaaeeoue ii?ooaiiy iaoai?ci?a aaeuei?aiiai eiio?ieth c aieo ei?e aaeeeeo i?aeoeue, ye? i?eaiaeyoue aei a?ia?aeoeaaoe?? iae?ii?a i?aee??eiaeo ooai?aiue. Oa?aeoa? cacia/aieo i?ioean?a iiaeia oeoia/eoe ia iniia? no/anii? oai??? ?icaeoeo iaoieia?/ieo i?ioean?a a ia?aia?e nenoai? - oai??? ooai?aiiy aeaoa?i?iaioieo no?oeoo? (E?uaeaiianeee A.I. 1990). A i?aee??eiaeo iae?iiao oi?io?oueny oieon a?ia?aeoeaiiai caoaeaeaiiy, yeee aoyao? a iaoieia?/io ?aaeoe?th iae?iie ?ioeo ??aiae ia?aiai? nenoaie. Aiane?aeie oeueiai ooai?th?oueny iaoieia?/ia aeaoa?i?iaioa, yea ? oi?i?aiei ? ea??aiei eaioethaii iaoieia?/ii? nenoaie, ui eaaeeoue a iniia? ?icaeoeo ?aii?o i?iya?a iaiaaiioieneeico. Oeae iaoieia?/iee i?ioean ia ?aii?o aoaiao ?icaeoeo i?iyaey?oueny ie?aieie, ia??cei ae?aaeaieie neiioiiaie, ye? /anoi aeyaeythoueny eeoa ca aeiiiiiaith ia?aee?i?/ieo iaoiae?a. Oe? neiioiie ua ia oi?iothoue /?oeee neiioiiieiiieaen ia ee?i?/iiio ??ai?. Oiio oi?ioaaiiy iaoieia?/ii? aeaoa?i?iaioii? nenoaie i?e noaee?i?/i?e noaae?? iaiaaiioieneeico ciaoiaeeoueny ia ii/aoeiaiio ??ai?, eiee ua ia ooai?eeeny aoi?eii? aeaoa?i?iaioe, oiaoi eiiiainaoi?ii-i?enoiniaoaaeuei? i?ioeane ua ? caeaoieie coieieoe iaaaoeai? ci?ie. Oea aaaeeeai aeey ciaoeiaeaeaiiy aeaoa?i?iaioe ca aeiiiiiaith e?eoaaiiy. I?e ?ic?iaoe? e?eoaaeueiiai eiiieaeno a?aoiaoaaeanue iaiao?aei?noue iaenei??oiai aeaaaeaiiy iaaeeeueo ia?aaioeth ?c i?aai?cio, i?aeneeaiiy AAIE-a?a?/ieo aaeuei?aieo iaoai?ci?a oa iie?ioaiiy iai?iieo i?ioean?a o iae?iiao, iioei?caoe?? ineoiooieoe?iiaeueiiai noaio iaoe??io?a. Eiiieaenia oa?ai?y i?iaiaeeeanue 24 aei? ? aeeth/aea i?eeii oaaeaoie iaeoeio ii 1,0 a /ioe?e ?ace ia aeaiue ia?aae ?aeath ?acii c oaaeaoeaie ai?iaeiio (i?eai?eiio) ii 0,5 a o?e ?ace a aeaiue. I?ney ?ae? iaoe??ioe io?eioaaee oiaeaa?o ii iaeiiio ae?aaea o?e ?ace a aeaiue ? acaoai o?e ?ace ia aeiao, aeico yeiai iinooiiai i?aeaeuoaaee c 0,075 a aei 0,2 a ia aeiao. E??i oiai, ?i i?ecia/aee iannaae, EOE oa o?c?ioa?aiaaoe/i? i?ioeaaeo?e, ye neiioiiaoe/io ? caaaeueiici?oeithaaeueio oa?ai?th. Iniae eiio?ieueii? a?oie io?eioaaee ieaoeaai cai?noue ai?iaeiio oa acaoaio, ?io? caoiaee aoee aiaeia?/i? oei, ui i?ecia/aeenue iaoe??ioai iniiaii? a?oie. Aiae?c ?acoeueoao?a e?eoaaiiy iaoe??io?a iniiaii? a?oie ca ?aa?anii neiioiiaoeee iieacaa, ui iaea?eueo aeeiai?/i? noa?eoeai? neiioiie (ia 81%) oa iieacieee ?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy (ia 86%), a nooi?iue ?aa?ano ia?eoeaieo neiioii?a iaoieia?? ia?aiai? nenoaie iaioa - 48%. Na?aae ooieoe?iiaeueieo ii?ooaiue a?aecia/aii iaea?eueo cia/ia iie?ioaiiy iieaciee?a aeui? ia?aiai? ae?yeueiino?, noaio ia?aiai-iyciaiai aia?aoo, aaaaoaoeaii? noa?e. I?e oeueiio ?aa?an ee?i?/ii? neiioiiaoeee ? ooieoe?iiaeueieo iieaciee?a aoa a iniiai?e a?oi? nooo?ai aeuee, a ii??aiyii? c eiio?ieueiith (?0,05). O oe?eiio i?iaaaeai? oa?aiaaoe/i? caoiaee a iniiai?e a?oii? i?eaaee aei iie?ioaiiy a 72% aeiaaee?a, ui aeinoia??ii a?eueoa, i?ae o eiio?ieuei?e - 28% (?0,02). Oea aeicaiey? c?iaeoe aeniiaee i?i iii?oiee iiceoeaiee aieea cai?iiiiiaaiiai e?eoaaiiy ia noai ia?aiai? nenoaie iaoe??io?a c noaee?i?/iith noaae??th iaiaaiioieneeico. Ia i?aenoaa? aeeeaaeaiiai, cai?iiiiiaaia nenoaia caoiaea iaaeeei-a?ieia?/ii? i?ioieaeoeee o?ii?/ii? ia?aaioeaai? ?ioieneeaoe?? o ai?ieeia. An? a??ieee iio?aaothoue ?aoe?iiaeueiiai oa?/oaaiiy c canoinoaaiiyi iaeoeiiaeo ?a/iaei, o e?eueeino? iaiao?aei?e aeey iaeneiaeueiiai aeaaaeaiiy iaaeeeoeo ia?aaioeth ?c i?aai?cio (ia iaioa i?ae 10 a ia aeiao). Iaaee/i iaeyaee i?aoeiaieeia, ye aeaooiaothoueny ia ?iaioo aai i?aoeththoue a eiioaeo? c ieeneaie ia?aaioeth i?iaiaeeeenue c canoinoaaiiyi nenoaie ia/enethaaeueii? aeaaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico. A aiaoeaoi?ieo oiiaao aecia/aeenue a??ieee c i?aeic?ith ia i?e?iiaiaaiioieneeic, ye? iio?i ianoaaeoaaeenue a noaoe?iia?? ca?aeii oaaeeoe? e?eoa???a ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico. Aeyaeaiiy i?e?iiaiaaiioieneeico ca aeiiiiiaith iaoaiaoe/ii? iiaeae? ae?aaiinoeee aeicaieeei i?aeaeueoe ?? oi/i?noue ? aoaeoeai?noue, nei?ioeoe aeo?aoe ia ianoaaeaiiy. Iaoe??ioai c noaee?i?/iith noaae??th iaiaaiioieneeico i?iaiaeeeinue e?eoaaiiy, aeeniaina?ia niinoa?aaeaiiy, a i?e no?ee?e iaoieia?/i?e neiioiiaoeoe? /e i?ia?anoaaii? i?e?iiaiaaiioieneeico ?aeiiaiaeoaaeinue ?aoe?iiaeueia i?aoeaaeaoooaaiiy ca iaaeaie ae?? II. Iia??oaiiy o iaoe??io?a c noaee?i?/iith noaae??th iaiaaiioieneeico ca?a?no?iaaii a 4,7% aeiaaee?a, oea o 2,8 ?aca iaioa, a ii??aiyii? c aeaieie A?aoe?ainueei? E.I. oa ni?aaao. (1985) - iia??oaiiy o oai?eo c ii/aoeiaeie noaae?yie ia?aaioeaai? ?ioieneeaoe?? aoei a 13,3% aeiaaee?a. I?ney i?iaaaeaiiy i?io?eaeoe/ieo caoiae?a a?aei?/aii cieaeaiiy COAI ia Ia?aaiaoeueeiio ACE?: ia 32% a aeiaaeeao ? 17% a aeiyo iai?aoeacaeaoiino?. A?aeaa?ioo? aeiiii?/i? caeoee ca ?aooiie oeueiai neeaee 881577 a?eaaiue. E??i oiai, a ?acoeueoao? i?iaaaeaiii? nenoaie i?io?eaeoeee ca ia??iae c 1995 ?ieo ii n?/aiue 1999 ?ieo, na?aae a??iee?a ia?aaioeaai? a??ie/i?oaeii? i?iieneiaino? Oe?a?ie ia ca?a?no?iaaii aeiaaee?a ia?aaioeaai? aioeaoaeiiao??. Oaeei /eiii, aeio?eiaiiy cacia/aieo i?eioeeiia i?io?eaeoeee iaiaaiioieneeico aeicaieeei cieceoe caoai?thaaiinoue na?aae ?ia?oiee?a ia?aaioeaai? i?iieneiaino?, iiia?aaeeoe ?icaeoie ia?aaioeaai? aioeaoaeiiao??, caa?aaoe o?oaeiai ?ano?ne oa ?aoeiiiaeueii aeei?enoiaoaaoe ?o ia iiaei?einoaao ai?ie/i?oaeii? ia?aaioeaai? i?iieneiainoi, caeiaooe cia/iiai nioeiaeueii-aeiiiii/iiai aoaeoo. AENIIAEE 1. O?ii?/iee aieea ia i?aai?ci a??iee?a aa?iciey aeac?ioaa?aoe?? ieene?a ia?aaioeth a eiioeaio?aoe?yo 0,4-16,0 ia/i3 iaoiiaeth? iaoieia?/i? aoaeoe c aieo ia?aiai? nenoaie. Aiie ?icaeaathoueny aiane?aeie iai?oaeaiiy iaoai?ci?a aaeaioaoe?? c ii/aoeiaeie i?iyaaie ?iceaaeiaiiy iae?iae?iai?/ieo aca?iicayce?a ? iae?iaoii?aeueii? ?aaoeyoe??, ye? aecia/athoue nooi?noue i?e?iiaiaaiioieneeico ? ?aae?cothoueny noaee?i?/ieie oa ee?i?/ieie ci?iaie. 2. O a??iee?a, caeiyoeo ia aeaeiaoaaii? oa caaaa/oaaii? ia?aaioeaaeo ?oae, aea o iia?o?? ?iai/i? ciie ai?no ieene?a ia?aaioeth a?eueoa ca AAeE a 2-50 ?ac?a, caoai?thaai?noue c oei/aniaith ao?aoith i?aoeacaeaoiino? aeua, ia 60% o aeiaaeeao ? ia 25-40% o aeiyo iai?aoeacaeaoiino?, i?ae o ?ia?oiee?a aiaeia?/ieo i?ioan?e cae?ci?oaeii? i?iieneiaino?, aea ai?no ieene?a ia?aaioeth a iaaeao AAeE. 2.1 Ianaeaiiy I?eiiieueneiai ia?aaioeaaiai aanaeio iaeaea a 4 ?ace /ano?oa oai??? ia o?aaeaiiy aeno?ai??ai?aeii? ia?aiai? nenoaie (a iioeeiio a?oe?) a ii??aiyii? c ianaeaiiyi i?iieneiaiai ?aa?iio E?eaaano, aea a ae?iaie/iio ? ioi/oaaeueiiio na?aaeiaeu? ieenee ia?aaioeth ia ia?aaeuothoue AAeE.. 3. Ii?oieia?/i? ci?ie a aieiaiiio iiceo aenia?eiaioaeueieo oaa?ei i?ae aieeaii ia?aaioeth na?ae/aoue i?i iayai?noue aeano?oeoe?? a ee?oeiao ei?e aieiaiiai iiceo, iici/eo, ae?aei? eoe?, ye? iathoue no?eeee oa?aeoa?. Ia oeueo?ano?oeoo?iiio ??ai? aiie i?iyaeythonuey ia?oe?aeueieie iae?icaie a oeeoiieaci? ? i?oioiiae??yo oa ii?ooaiiyie a no?oeoo?? i??e?iiaeo aieieii. 4. Noaee?i?/ia noaae?y iaiaaiioieneeico o a??iee?a oa?aeoa?eco?oueny i?aeaeuaiiyi ai?noo ia?aaioeth a aieinn? a?eueoa 3 ia% (95,5%-100,0%) ? i?iyaey?oueny ?icaeoeii iaa?iciiiae?aiiai noaio ( 69,6%-93,5% ) c aeaiaioaie niiaoeciaaii? aeai?an??, o?eaiaeiino?, anoai?caoe??, aeayeei cieaeaiiyi iianoe/ieo ooieoe?e, iacia/ieie ci?iaie eii?aeeiaoe?? ?oo?a (39,3%-71,2%), aaaaoaoeaiith ae?noii??th ii ia?aneiiaoe/iiio oeio (42,0%-73,7%), iacia/ieie ci?iaie oea?aa?aeueii? ? ia?eoa??/ii? aaiiae?iai?ee (36,6%-68,6%), ii?ooaiiyi a?iaeaeo?e/ii? aeoeaiino? iyc?a ii oeio aeno?ai??ai?aeii? iaaeinoaoiino? (53,7%-83,2%), ci?iaie iai?io eaoaoieai?i?a (19,1%- 49,3%) ? aoeao?eoie?io (26,3%-57,9%). 5. Aeey ae?aaiinoeee i?e?iiaiaaiioieneeico iaea?eueo cia/oueie e?eoa??yie ?: i?aeaeuaiiy ai?noo ia?aaioeth o aieinn? (ae?aaiinoe/ia ?ioi?iaoeai?noue aei??aith? 3,261) , noaee?i?/i? ii?ooaiiy eii?aeeiaoe?? ?oo?a - (2,969), ia?aneiiaoeeioii?y ca ?iaeaenii Ea?aei - (1,292), ii?ooaiiy iinoo?aeueieo ?aoeaen?a - (0,556), iiyaa ?aoeaen?a i?aeueiiai aaoiiaoecio - (0,556). 6. Ia iniia? iaoiiao?e/iiai aeai?eoio, c aeei?enoaiiyi iaea?eueo ?ioi?iaoeaieo e?eoa???a oa ioe?iee cia/ouino? ?o a?aaeaoe?e a aaeao, ?ac?iaeaia iaoaiaoe/ia iiaeaeue ae?aaiinoeee ?aii?o i?iya?a iaiaaiioieneeico. Aiia aeicaiey? a aiaoeaoi?ieo oiiaao ca iaai?ii aeyaeaieo neiioii?a aecia/eoe eiia??i?noue ?icaeoeo iaoieia??, a iio?i i?e iiaeeaeaiiio noaoe?iia?iiio ianoaaeaii? i?eeiyoe inoaoi/ia ??oaiiy i?i iayai?noue i?e?iiaiaaiioieneeico. Ai?iaaoe?y oe??? iiaeae? iieacaea ?? 94%-ao aoaeoeai?noue. 7. ?ic?iaeaia eiiieaenia nenoaia i?io?eaeoeee iaiaaioieneeico, yea aeeth/a?, e??i ?aiiuei? ae?aaiinoeee iaiaaioieneeico ca aeiiiiiaith iaoiiao?e/ieo oaaeeoeue, iaaee/i? caoiaee c aeaaaeaiiy iaaeeeoeo ia?aaioeth ?c i?aai?cio oa aeoeaaoe?th naiiaaiaoe/ieo iaoai?ci?a. Aeey oeueiai an?i a??ieeai ?aeiiaiaeiaaii iino?eiee i?eeii iaeoei?a ia iaioa 10 a?aii ia aeiao ca ?aooiie naaeainiaaiiiai oa?/oaaiiy, caaaa/aiiai i?iaeoeoaie, ye? ai?uathoue iaeoei. A??ieee c i?e?iiaiaaioieneeicii iio?aaothoue aeeniaina?iiai iaaeyaeo oa i?iaaaeaiiy ?aaa?e?oaoe?eii? oa?ai?? c aeei?enoaiiyi acaoaio, ai?iaeiio, iaeoei?a, a?oai?i?a, o?c?ioa?aiaaoe/ieo i?ioeaaeo?. Oe? caoiaee caaacia/othoue a 72% aeiaaee?a aoaeoeaio i?io?eaoeeo iaiaaiioieneeico. I?AEOE*I? ?AEIIAIAeAOe?? 1. Ia ia?aeiieo (i?e aeaoooaaii? ia ?iaioo) oa ia?iiaee/ieo iaaee/ieo iaeyaeao iaiao?aeii ?aoaeueii i?iaiaeeoe iaa?ieia?/iee iaeyae c canoinoaaiiyi ia/enethaaeueii? ae?aaiinoeee ca?aeii iaoiiao?e/ii? oaaeeoe? e?eoa???a aeey aeyaeaiiy in?a c i?aeic?ith ia i?e?iiaiaaiioieneeic. 2. Inoaoi/io ae?aaiinoeeo noaee?i?/ii? noaae?? iaiaaiioieneeico o?aaa i?iaiaeeoe a noaoe?iia?? i?ney aecia/aiiy ae?aaiinoe/ieo e?eoa???a oeueiai noaio ca?aeii iaoiiao?e/ii? oaaeeoe? e?eoa???a ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico. Iniae, a yeeo anoaiiaeai? ?aii? i?iyae iaiaaiioieneeico iio?aaothoue aeeniaina?iiai iaaeyaeo ? i?iaaaeaiiy i?ioieaeoe/iiai e?eoaaiiy, i?e i?ia?anoaaii? iaoieia?/ieo ci?i ?aoe?iiaeueiiai i?aoeaaeaoooaaiiy ca iaaeaie ae?? ieene?a ia?aaioeth. 3. An? a??ieee, ye? ia ae?iaieoeoa? i?aeiaaeathoue i?ae aieea ieene?a ia?aaioeth, iio?aaothoue ?aoe?iiaeueiiai oa?/oaaiiy c ai?uaiiyi iaeoei?a o e?eueeino? iaiao?aei?e aeey nai?/aniiai aeaaaeaiiy iaaeeeoeo ia?aaioeth. 4. I?e e?eoaaii? oa iaaee/i?e ?aaa?e?oaoe?? a??iee?a c i?e?iiaiaaiioieneeicii a eiiieaeni?e oa?ai?? ne?ae aeei?enoiaoaaoe ineoio?iii? oa AAie-a?a?/i? i?aia?aoe. nienie iioae?eiaaieo i?aoeue ca OAIith AeENA?OAOe 1. ssuaiei A.A. Ninoiyiea oieeia?ae/aneie e neiiaoiaae?aiaeiaie nenoai o ai?ii?aai/eo i?e aeeeoaeueiii aicaeaenoaee ieeneia ia?aaioea // E?ea?nueea ni?aaa. -1998.-?6.-N. 152-155. 2. ssuaiei A.A. E aeeaaiinoeea noaeeeie/aneie ia/aeueiie noaaeee iaiaaiioieneeica // E?ea?nueea ni?aaa. -1998.-?5.-N. 65-68. 3. ssuaiei A.A. Ooieoeeiiaeueiua eciaiaiey i?e noaeeeie/aneie noaaeee iaiaaiioieneeica o ai?iyeia// E?ea?nueea ni?aaa. -1998.-?4.-N. 136-138. 4. ?aiiea i?iyaeaiey aicaeaenoaey ieeneia ia?aaioea ia i?aaieci ?aai/eo / Iaoiaiei A.N., ssuaiei A.A., Aeai?ie/aiei A.A., Eieaniee O.I., Aaiii A.A. // Aeaeaia, oieneeieiaey, oeceieiaey o?oaea e i?ioiaoieiaey a i?iiuoeaiiinoe. - E?eaie ?ia: E?eai?iaeneee IEE AO e IC. - 1995.-N.201-204. 5. Iaoaio 15154A Oe?a?ia, IEE A61A10/00. Niin?a ae?aaiinoeee noaee?i?/ii? noaae?? iaiaaiioieneeico / ssuaiei A.A., Iaoiaiei A.N., Eoaianueeee N.I., Aaiii A.I. (Oe?a?ia); E?eai??cueeee IAe? AI oa IC. - ? 95010026; Cayae. 02.01.1995; Iioae. 30.06.1997; Athe. ?3.- 3n. 6. Iaoaio 21074A Oe?a?ia, IEE A61E31/725. Niin?a e?eoaaiiy ?aii?o i?iya?a ia?aaioeaai? ?ioieneeaoe???/ Iaoiaiei A.N., Aeai?ie/aiei A.A., ssuaiei A.A. (Oe?a?ia); E?eai??cueeee IAe? AI oa IC. - ? 95125366; Cayae. 19.12.1995; Iioae. 27.02.1998; Athe. ? 1.- 2n. 7. ssuaiei A.A., Aeai?ie/aiei A.A. Iaoiineoieiai/ii ciiie o ai?ieeia iiae aieeaii ieeneia ia?aaioeth // Aeooaeueiua i?iaeaiu i?ioanneiiaeueiie iaoieiaee e ?aaeeaoeeiiiie iaaeeoeeiu (iaoa?eaeu iao/ii-i?aeoe/aneie eiioa?aioeee 13 iay 1994a.).- Aeiiaoee, 1994. -N.239. 8. ssuaiei A.A., Iaoiaiei A.N. Iaoiiao?e/aneee aeai?eoi a aeeaaiinoeea aeieeeie/aneeo ninoiyiee iaiaaiioieneeica // Aeooaeueiua aii?inu aeaeaiu, oieneeieiaee,oeceieiaee o?oaea e i?ioiaoieiaee ai?ii?oaeiie e iaoaeeo?ae/aneie i?iiuoeaiiinoe (oacenu aeieeaaeia iao/ii-i?aeoe/aneie eiioa?aioeee, iinayuaiiie 40-eaoeth einoeoooa, iae 1995a.). - E?eaie ?ia: E?eai?iaeneee IEE AO e IC.- 1995.-N.71. 9. ssuaiei A.A., Aeai?ie/aiei A.A., Iaoiaiei A.N. Ninoiyiea ineoiiaa?ieiae/aneiai noaoona o ai?ii?aai/eo n aeiiicieiae/aneeie i?iyaeaieyie iaiaaiioieneeica // Aeooaeueiua aii?inu aeaeaiu, oieneeieiaee, oeceieiaee o?oaea e i?ioiaoieiaee ai?ii?oaeiie e iaoaeeo?ae/aneie i?iiuoeaiiinoe (oacenu aeieeaaeia iao/ii-i?aeoe/aneie eiioa?aioeee, iinayuaiiie 40-eaoeth einoeoooa, iae 1995a.). - E?eaie ?ia: E?eai?iaeneee IEE AO e IC. - 1995. -N.72. 10. Iaoiaiei A.N., ssuaiei A.A., Aeai?ie/aiei A.A. Aaaaoaoeaii-noaeeiia aeinoiiiy o ai?ieeia iiae aieeaii ieeneia ia?aaioeth //IV c”icae ea?aeiieiaia Oe?aiie / Oace aeiiiaiaeae, Aeiii?iiao?ianuee, 15-17 aa?aniy, 1993. - Ee?a, 1993,-N.126. 11. Iniaaiiinoe caaieaaaaiinoe ?aai/eo i?aaei?eyoee ii aeiau/a e iaiaauaieth ia?aaiaoeniaea?aeaueo ?oae Ia?aaiaoeeiai AIEa / Iaoiaiei A.N., Aaiii A.A., Aeai?ie/aiei A.A., ssuaiei A.A. // Nia?aiaiiua i?iaeaiu aeaeaiu, yeieiaee e io?aiu caei?iauey / Oac.aeiee.OII nuacaea aeaeaienoia Oe?aeiu, Iaeanna, 2-5 ieoya?y 1991a.- Ee?a, 1991. - N.144-145. Aiioaoe?y ssuaiei A. A. Noai ia?aiai? nenoaie a??iee?a, ye? eiioaeoothoue c ieeneaie ia?aaioeth.-?oeiien. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeueiinoth 14.01.15 - ia?aia? oai?iae. - Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie, Ee?a, 1999. Aeena?oaoe?th i?enay/aii ieoaiiyi ae?aaiinoeee ? i?io?eaeoeee ?aii?o i?iya?a ia?aaioeaai? ?ioieneeaoe?? o a??iee?a. Anoaiiaeaii, ui a oiiaao aieeao ieene?a ia?aaioeth iathoue i?noea iacia/ii ae?aaeai? ci?ie c aieo ia?aiai? nenoaie, ye? oi?iothoue noaee?i?/io noaae?th iaiaaiioieneeica. A eiai iaoiaaiac? aaaeeeaa cia/aiiy iathoue yaeua aeano?oeoe?? ee?oei ei?e aieiaiiai iiceo, iici/eo, ae?aei? eoe? oa aeieeiaiiy aeaoa?i?iaioieo no?oeoo? ia ??cieo ??aiyo oeaio?aeueii? ia?aiai? nenoaie. Onoaiiaeai? e?eoa??? aeey ?aiiuei? ae?aaiinoeee ia?aaioeaai? ?ioieneeaoe?? iathoue iaae?ei?noue 94%. Aoaeoeai?noue ?ic?iaeaiiai niiniao e?eoaaiiy ?aii?o i?iya?a ia?aaioeaai? ?ioieneeaoe?? aeinyaa? 72%. Ai?iaaaeaeaiiy iaaee/ii? i?io?eaeoeee iaiaaiioieneeico aeicaieeei cieceoe caaaeueio caoai?thaai?noue a??iee?a ia?aaioeaai? i?iieneiaino?, ui iaoiiaeth? noooaaa nioe?aeueia oa ia?iaeiiainiiaea?nueea cia/aiiy aeine?aeaeaiue. Eeth/iai neiaa: ia?aiaa nenoaia, a?ieee, ia?aaioeaaa ?ioieneeaoe?y, e?eoa??? ?aiiuei? aeiaaiinoeee, i?ioieaeoeea. Summary Jashchenko A. The state of nerves system in miners, who contact with oxide manganese.-Manuscript. Thesis of competition for a candidates degree of medical sciences by speciality 14.01.15 - nervous diseases. - Kyiv Medical Academy of Post-Graduated Education named after P. Shupyk Health Ministry of Ukraine, Kyiv, 1999. The dissertation is dedicated to the problems of diagnostics and prophylaxis of early manifestations of manganese intoxication in miners. It was determined that the impact of manganese oxides resulted to slight alterations in nervous system. These alterations form a subclinical stages of manganese toxicosis. Phenomena of destruction in cortex's, pallidum`s and in cerebellum's cells as well as the appearance of determinantal structures on different levels of central nervous system are of a great relevance for micromanganesetoxicosis pathogenesis. The fixed criteria for early diagnostics of manganese intoxication have 94% assurance. The efficiency of the elaborated way of treatment of early manifestations of the diseases is up to 72%. The application of medical prophylaxis of manganese toxicosis promotes the reducing of morbidity of miners in manganic industry, that causes a great social and economical importance of the researches. Key words: nervous system, miners, manganese intoxication, criteria of early diagnostics, prophylaxis. Aiiioaoeey ssuaiei A.A. Ninoiyiea ia?aiie nenoaiu ai?ii?aai/eo, eiioaeoe?othueo n ieeneaie ia?aaioea. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.15 - ia?aiua aieacie. - Eeaaneay iaaeeoeeineay aeaaeaiey iineaaeeieiiiiai ia?aciaaiey ei. I.E. Ooieea IC Oe?aeiu, Eeaa, 1999. I?aaenoaaeaia e caueoa aeenna?oaoeey e 11 iao/iuo ioaeeeaoeee, a eioi?uo iao/ii iainiiaaiu aeeaaiinoeea e ea/aiea ?aiieo i?iyaeaiee o?iie/aneie ia?aaioeaaie eioieneeaoeee o ?aai/eo ai?ii?oaeiiai i?iecaiaenoaa. Auyaeaii oaaee/aiea caaieaaaaiinoe n a?aiaiiie oo?aoie o?oaeiniiniaiinoe (ia 60% a neo/ayo, ia 25-40% a aeiyo iao?oaeiniiniaiinoe) o ai?ii?aai/eo, caiyouo aeiau/ae e iaiaauaieai ia?aaioeaauo ?oae, ii n?aaiaieth n ai?iyeaie aiaeiae/iuo i?ioannee aeaeaci?oaeiie i?iiuoeaiiinoe. Onoaiiaeaii, /oi o ai?ii?aai/eo a oneiaeyo aicaeaenoaey ieeneia ia?aaioea a eiioeaio?aoeeyo 0,4-16,0 ia/i3 eiatho ianoi ioaeaeueiua, ia?acei au?aaeaiiua eeeieei-eaai?aoi?iua e ooieoeeiiaeueiua eciaiaiey ni noi?iiu ia?aiie nenoaiu, eioi?ua oi?ie?otho noaeeeie/aneoth noaaeeth iaiaaiioieneeica. Ioia/athony iacia/eoaeueiua ia?ooaiey eii?aeeiaoeee aeaeaeaiee, eciaiaiey aeiyeaeo?e/aneie aeoeaiinoe iuooe ii yeno?aie?aieaeiiio oeio, iacia/eoaeueii au?aaeaiiay ia?aneiiaoeeioiiey, aaiiaeeiaie/aneea eciaiaiey ii oeio aeenoiiee ninoaeia i?aeiouanoaiii n a?oa?einiaciii, eciaiaiey iieacaoaeae neiiaoiaae?aiaeiaie e oieeia?ae/aneie nenoai. ?aaeno?e?othony ioaeaeueiua, neaai au?aaeaiiiua iauaeoeaiua iaa?ieiae/aneea neiioiiu, eioi?ua, eae i?aaeei, auyaeythony n iiiiuueth niaoeeaeueiuo i?ia. ?acaeaaaony iaa?iciiiaeiaiia ninoiyiea, eioi?ia nii?iaiaeaeaaony yeaiaioaie niiaoece?iaaiiie aeai?annee, o?aaiaeiinoe, anoaiecaoeee ia oiia ia?acei au?aaeaiiiai nieaeaiey iianoe/aneie ooieoeee, caiaaeeaiey iiaeaeaeiinoe ia?aiuo i?ioeannia. E?iia yoiai, auyaeyaony iiauoaiea niaea?aeaiey ia?aaioea a aieinao aieueoa 3 ia%. A iaoiaaiaca iee?iiaiaaiioieneeica aaaeiia cia/aiea eiatho yaeaiey aeano?oeoeee eeaoie ei?u aieiaiiai iicaa, iicaea/ea, aeaaeiiai oa?a e aicieeiiaaiea aeaoa?ieiaioiuo no?oeoo? ia ?acee/iuo o?iaiyo OeIN. Ia iniiaa iaoiiao?e/aneiai aeai?eoia e ae?oaeo iaoiaeia iaoaiaoe/aneie noaoenoeee ?ac?aaioaia iiaeaeue aeeaaiinoeee iaiaaiioieneeica. Onoaiiaeaiu iaeaieaa eioi?iaoeaiua e?eoa?ee ii?aaeaeaiey noaeeeie/aneie noaaeee ia?aaioeaaie eioieneeaoeee n eiiieaeniie ioeaieie cia/eiinoe eo a?aaeaoeee a aaeeao. ?ac?aaioaiu aeaa aeeaaiinoe/aneea iaoiiao?e/aneea oaaeeoeu: ia?aay ec ieo iicaieyao a aiaoeaoi?iuo oneiaeyo ii iaai?o auyaeyaiuo neiioiiia auno?i ii?aaeaeeoue aiciiaeiia ?acaeoea iaoieiaee, aoi?ay - ?ann/eoaia ia aieaa aeoaieia ianeaaeiaaiea a oneiaeyo noaoeeiia?a, aeey ieii/aoaeueiiai ?aoaiey i iaee/ee eee ionoonoaee iee?iiaiaaiioieneeica. Aeey aeeaaiinoeee iee?iiaiaaiioieneeica iaeaieaa cia/eiuie e?eoa?eyie yaeythony: iiauoaiea niaea?aeaiey ia?aaioea a aieinao, noaeeeie/aneea ia?ooaiey eii?aeeiaoeee aeaeaeaiee, ia?aneiiaoeeioiiey ii eiaeaeno Ea?aei, ia?ooaiea iinoo?aeueiuo ?aoeaenia, iiyaeaiea ?aoeaenia i?aeueiiai aaoiiaoecia. Eniieueciaaiea iaoiiao?e/aneie iiaeaee aeeaaiinoeee ia i?aeoeea iieacaei a? iaaeaaeiinoue a 94 i?ioeaioao neo/aaa. I?aaeeiaeaiiue niinia ea/aiey ?aiieo i?iyaeaiee ia?aaioeaaie eioieneeaoeee iniiaai ia oneeaiee AAIE-a?ae/aneeo oi?iiciuo iaoaieciia OeIN, auaaaeaiee ia?aaioea ec i?aaiecia, iioeiecaoeee ineoiooieoeeiiaeueiiai ninoiyiey iaoeeaioa. Yoe iaoiaeu ai?iae?iaaiu a oneiaeyo eeeieee Oe?aeineiai IEE i?iiuoeaiiie iaaeeoeeiu, ea/aaii-i?ioeeaeoe/aneeo o/?aaeaeaiee Aeiai?iiao?ianeie, Caii?iaeneie iaeanoae e eiatho 72%-ioth yooaeoeaiinoue. ?ac?aaioaia noaia iaaeeoeeineie i?ioeeaeoeee ia?aaioeaaiai ia?eeiniiecia ia iniiaa aeeniaina?iiai iaaethaeaiey ca ?aai/eie, naiaa?aiaiiie iiyoaiiie aeeaaiinoeee ?aiieo i?iyaeaiee o?iie/aneie ia?aaioeaaie eioieneeaoeee, i?ioeeaeoe/aneiai ea/aiey e ?aoeeiiaeueiiai o?oaeiono?ienoaa ai?iyeia aia eiioaeoa n ieeneaie ia?aaioea. Aiaae?aiea nenoaiu i?ioeeaeoe/aneeo ia?ii?eyoee iicaieeei nieceoue iauoth caaieaaaaiinoue ai?iyeia ia?aaioeaaie i?iiuoeaiiinoe e i?aaeoi?aaeeoue ?acaeoea o ieo ia?aaioeaaie yioeaoaeiiaoee, /oi iaoneiaeeaaao aieueoia nioeeaeueiia e ia?iaeiioicyenoaaiiia cia/aiea. I?aaeioa?auaiiue yeiiiie/aneee oua?a ninoaaee 881577 a?eaai ca aiae. Eeth/aaua neiaa: ia?aiay nenoaia, ai?iyee, ia?aaioeaaay eioieneeaoeey, e?eoa?ee ?aiiae aeeaaiinoeee, i?ioeeaeoeea.

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