?inoeooo aa?iioieia?? AII Oe?a?ie

Uiaae

Ieaenaiae? ?aaiiae/

OAeE:612.171:616.12-072.7

Niaeo?aeuei? oa?aeoa?enoeee ia?oiai na?oeaaiai oiio

ye ia?ea? ooieoe?iiaeueiiai noaio i?iea?aea

14.03.03- ii?iaeueia o?c?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oaeai?iaenueeiio aea?aeaaiiio oi?aa?neoao?.

Iaoeiaee ea??aiee: aeieoi? a?ieia?/ieo iaoe, i?ioani? Oaeaoa Aieiaeeie?
Iao?iae/, Oaeai?iaenueeee aea?aeaaiee oi?aa?neoao, caa?aeoaa/ eaoaae?e
ii?iaeueii? oa iaoaeia?/ii? o?c?ieia??.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, aeaaeai?e AII Oe?a?ie ,
/e.ei?. ?AII, i?ioani? Ei?eooei Ieaa Aaneeueiae/ , ?inoeooo aa?iioieia??
AII Oe?a?ie, ea??aiee a?aeae?eo ee?i?/ii? o?c?ieia?? ? iaoieia??
aioo??oi?o i?aai?a;.

aeieoi? iaaee/ieo iaoe, i?ioani? Nao?iiiaa Aaeeia Ai?en?aia,
Euea?anueeee aea?aeaaiee ?inoeooo o?ce/ii? eoeueoo?e , caa?aeoaa/
eaoaae?e o?ce/ii? ?aaa?e?oaoe??

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.
Aiaiiieueoey, IIC Oe?a?ie, (eaoaae?a ii?iaeueii? o?c?ieia??) i. Ee?a

Caoeno a?aeaoaeaoueny “ 6 ” o?aaiy 1999 ?. i 13-00 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.551.01 a ?inoeooo? aa?iioieia?? AII
Oe?a?ie, i.Ee?a, aoe.Aeoai?iaenueea, 67.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?inoeoooo
aa?iioieia?? AII Oe?a?ie (i.Ee?a, aoe.Aeoai?iaenueea, 67).

Aaoi?aoa?ao ?ic?neaiee “ 4 ” ea?oiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe
Iioaiaiei ?.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Aaeineiiaeaiiy ?ino?oiaioaeueieo iaoiae?a
aeine?aeaeaiiy ?iaioe na?oey ? iaei??th c iaeaaaeeea?oeo i?iaeai, ui
ciaoiaeyoueny a oeaio?? oaaae aeine?aeiee?a na?oeaai-noaeeiii? nenoaie.
I??i?eoao iaaea?oueny ia?iaaceaiei iaoiaeai. Iaoiaeeee aeine?aeaeaiiy
na?oeaai? ae?yeueiino?, ui canoiniaothoueny a ee?i?oe?, ? a o?e /e ?io?e
i??? iia’ycaieie c ioe?ieith nei?ioeeaino? na?oeaaiai i’yca
(A.A.Eiinoaioeiia ? ni?aaao., 1989; N.E.A?o?oe, 1990).

A?aeiia cia/aiiy a oeueiio a?aeiioaii? iaaoee iie?ea?ae?ia?ao?/iee ?,
iniaeeai, aoiea?ae?ia?ao?/iee iaoiaee aeine?aeaeaiiy (I.A.Ei?eooei,
1983; I.Cosme, R.S.Grodman, 1997). Aea aoaathoue aeiaaeee, eiee i?e
yai?e iaoieia?? na?oeaaiai i’yca iieacieee oaciai? no?oeoo?e na?oeaaiai
oeeeeo nooo?ai ia ci?iththoueny (N.Eiea?ia ? ni?aaao., 1979). Ca aeaieie
I.Oeeea?a, I.Ineiiaa (1993) o eiaeiiai o?aoueiai oai?iai c yaeuaie
cano?eii? na?oeaai? iaaeinoaoiino? aoiea?ae?ia?ao?/i? iieacieee
nei?i/aiiy ia ii?ooai?, a i?e/eia ?icaeoeo ea?ae?aeueii? neiioiiaoeee
iieyaa? a ii?ooaii? e?iaiiaiiaiaiiy e?aiai oeoii/ea, oiaoi a eiai
ae?anoie?/i?e aeenooieoe??. O ca’yceo c oeei ana aeooaeuei?oith noa?
ioe?iea ooieoe?iiaeueiiai noaio i?iea?aea ca aia?aaoe/ii aeoeaiei
i?ioeanii — ?icneaaeaiiyi (A.A.O?ieuee?n ? ni?aaao., 1994; I.I.I?e?o?i,
A.N.Iiena?a, 1998; I.Nia?aeae?n, 1990). E??i oiai, ia ?aii?o noaae?yo
caoai?thaaiue na?oeaaiai i’yca iiaeeea? eieaeuei? ii?ooaiiy
nei?ioeeaino?, ye? /anii aaaeei aeyaeoe (A.A.Noia?ieia, A.N.Iiena?a,
1985). O?aaeeoe?ei? iaoiaee aeine?aeaeaiiy aeathoue ioe?ieo
eiio?aeoeeueiino? i?iea?aea ye oe?e?niiai i?aaio, ia a?aoiaoth/e
iniaeeainoae eiai ye oeaieie.

Ca?aeii c aeuaneacaiei, aeooaeueiith i?iaeaiith ? iiaeaeueoa aea/aiiy
niinia?a ia?iaaceaii? ioe?iee ooieoe?iiaeueiiai noaio na?oeaaiai i’yca.
sse a?aeiii, nei?i/aiiy na?oey i?ecaiaeeoue aei aaia?aoe?? a?a?aoe?e,
ye? ooai?ththoue ia?oee oii. O eiai neeaae? ? oae caaiee i’yciaee
eiiiiiaio. C oi/ee ci?o a?io?ce/ii? a?a?aoe?eii? a?iioace a iniia?
i?iea?ae?aeueieo caoe?a eaaeaoue aneio?iii? eieeaaiiy i’yciaeo aieieii
i?ae /an nei?i/aiiy. Ca aeaieie inoaii?o aeine?aeaeaiue /anoioiee
?ioa?aae 20-60 Aoe ? naia i?iea?ae?aeueiiai iioiaeaeaiiy (A.I.Oaeaoa,
1987). Ca?aene aeieeaa? ?iai/a a?iioaca i?i oa, ui eiai ia?aiao?e
iiaeia aeei?enoaoe aeey oa?aeoa?enoeee iniaeeainoae no?oeoo?e na?oeaaiai
i’yca o ca’yceo ?c nei?ioeea?noth.

O aeinooii?e e?oa?aoo?? ie ciaeoee iacia/io e?euee?noue ?ia?o,
iia’ycaieo c aeine?aeaeaiiyie aiie?ooaeii-/anoioieo oa?aeoa?enoee
aeaiiai eiiiiiaioa. A?eueo?noue aeine?aeiee?a aaaaeathoue i’ycia?
eieeaaiiy iecueeiaiie?ooaeieie. I?ioa i?e i?iaaaeaii? niaeo?aeueiiai
aiae?co a?aei?/aii, ui iaeneioi caoeiai? aia?a?? a niaeo?? ciaoiaeeoueny
a iecueei/anoioiiio ?ioa?aae? (P.D.Ste?n et al., 1984).

A?aoiaoth/e aeuaiaaaaeaia, i?aaeiaoii aeena?oaoe?eii? ?iaioe ie ia?aee
aeine?aeaeaiiy niaeo?aeueieo oa?aeoa?enoee ia?oiai oiio, aeoeaiooth/e
oaaao ia caoeao i?iea?ae?aeueiiai iioiaeaeaiiy c iaoith ae?iaeaiiy
niaeo?ioiiiea?ae?ia?ao?/ieo e?eoa???a nei?ioeeaino?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie ? oaiaie.
Aeena?oaoe?y aeeiiaia a ?aieao iaoeiai-aeine?aeii? oaie «?ic?iaea
iiaiai ?ino?oiaioaeueiiai iaoiaeo ioe?iee ooieoe?iiaeueiiai noaio
i?iea?aea ia iniia? eiii’thoa?ii? niaeo?aeueii? oiiiea?ae?ia?ao??», ?
aea?ae?a?no?aoe?? 0196U003256.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith aeaii? ?iaioe aoei
anoaiiaeaiiy ?ioi?iaoeaieo e?eoa???a aiie?ooaeii-/anoioii?
oa?aeoa?enoeee ia?oiai oiio, ye? a a?aeia?aaeaee ?iio?iiiee noai
i?iea?aea, ? aea/aiiy iiaeeeaino? ?o aeei?enoaiiy aeey ioe?iee
ooieoe?iiaeueiiai noaio na?oeaaiai i’yca a o?c?ieia?/ieo oiiaao, a
oaeiae i?e i?iea?ae?aeuei?e iaoieia??.

Aeey aeinyaiaiiy oe??? iaoe ae??ooaaeeny iniiai? caaaeaiiy:

1. ?ic?iaea aaoiiaoeciaaii? onoaiiaee, yea a aeaea iiaeeea?noue oaeaeei
io?eioaaoe /anoioiee niaeo? ia?oiai oiio, aecia/aoe /anoioe c
iaeneiaeueieie aiie?ooaeaie, ae?aoiaoaaoe a?aeiinio caoeiao aia?a?th ia
aoaeue-yeiio /anoioiiio ?ioa?aae? a iaaeao aeine?aeaeoaaiiai
/anoioiiai ae?aiaciio.

2. Aeyaeaiiy /anoioiiai ?ioa?aaeo ia?oiai oiio, iaea?eueo /ooeeaiai aei
ci?i nei?ioeeaino? i?iea?aea.

3. Ni?anoaaeaiiy aaee/eie aia?a?? iaea?eueo /ooeeaeo aei ?iio?iiieo

aieea?a iecueei/anoioieo neeaaeiaeo oiio c iieacieeaie nei?ioeeaino? ca
aeaieie I-aoiea?ae?ia?ao?? aeey anoaiiaeaiiy iayaiino? ?
oa?aeoa?o aca?iica’yce?a i?ae ieie.

4. Anoaiiaeaiiy caeiiii??iinoae ia?a?iciiae?eo caoeiai? aia?a?? o

/anoioiiio ae?aiacii? ia?oiai oiio a caeaaeiino? a?ae ?iio?iiiiai
noaio i?iea?aea c iaoith ae?iaeaiiy oi?o?eiaaieo niaeo?aeueieo
iieaciee?a nei?i/aiiy i?iea?aea.

5. Ioe?iea ee?i?/ii? ?ioi?iaoeaiino? niaeo?aeueieo iieaciee?a ia?oiai
oiio aeey ae?aaiinoeee ii?ooaiiy eiio?aeoeeueiino? o oai?eo ?oai?/iith
oai?iaith na?oey.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. ?iaioa a?ae??ciy?oueny a?ae
?ai?oa aeeiiaieo iiaei i?aeoiaeii aei ioe?iee nei?ioeeaino? i?iea?aea
oeyoii canoinoaaiiy iaoiaeo niaeo?aeueii? oiiiea?ae?ia?ao?? c
aeei?enoaiiyi eiii’thoa?ii? oaoi?ee. Ia iniia? aeanieo aeine?aeaeaiue
aia?oa iieacaiee o?niee aca?iica’ycie i?ae aia?a??th iecueeeo /anoio
ia?oiai oiio (AI*N) oa nei?i/aiiyi na?oey ? c iiaeo iiceoe?e
i?aeoaa?aeaeaii a?iioaco i?i aioo??oiueii?iea?ae?aeueia iioiaeaeaiiy
iecueei/anoioieo neeaaeiaeo. O aeeneon?? a?aeiinii iioiaeaeaiiy
ia?oiai oiio aianai? a?aoiaioe, ye? na?ae/aoue i?i aaaiio o/anoue
i’yciaiai eiiiiiaioa a eiai ooai?aii?.

Aia?oa cai?iiiiiaai? oi?o?eiaai? niaeo?aeuei? iieacieee nei?ioeeaino?
oa iaoiae e?euee?nii? ioe?iee eiio?aeoeeueiiai ?aca?ao i?iea?aea ca
aeaieie niaeo?aeueiiai aiae?co ia?oiai oiio. Ae?noaei iiaeaeueoee
?icaeoie canoinoaaiiy iaoiaeo aeey ae?aaiinoeee cieaeaiiy
eiio?aeoeeueiiai ?aca?ao i?e i?iea?ae?aeuei?e iaoieia??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?acoeueoaoe
aeine?aeaeaiiy aeeaoa ?ice?eaathoue ?ieue i’yciaiai eiiiiiaioa o
no?oeoo?? ia?oiai oiio ? ooi/iththoue eiai aaiac. Ciaeaeai?
niaeo?aeuei? iieacieee nei?ioeeaino? ni?eythoue i?aeaeuaiith
ae?aaiinoe/ii? ?ioi?iaoeaiino? iaoiaeeee niaeo?aeueii?
oiiiea?ae?ia?ao??. ?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a
iaa/aeueiee i?ioean ia eaoaae?? ii?iaeueii? oa iaoieia?/ii? o?c?ieia??
iaaee/iiai oaeoeueoaoo Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo i?e
aea/aii? ?icae?eo «O?c?ieia?y e?iaiia?ao».

Io?eiai? aeai? oaeiae iiaeooue aooe aeei?enoai? o iaaeeoeei? – aeey
ioe?iee ooieoe?iiaeueiiai noaio i?iea?aea a aeeiai?oe? i?e ??cieo
caoai?thaaiiyo na?oey, ioe?iee aoaeoeaiino? e?eoaaiiy oai?eo
ea?ae?ieia?/iiai i?io?eth ? aecia/aiiy i?iaiico caoai?thaaiiy; o nii?o?
— aeey eiio?ieth yeino? o?aioaaeueiiai i?ioeano oiui.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa aeeiiaia iniaenoi
caeiaoaa/ai. Aaoi?ii noi?ioeueiaaii iaoo oa caaea/? aeine?aeaeaiiy,
i?iaaaeaii aiae?c iaoeiai? e?oa?aoo?e, io?eiaii oa i?iaaaeaii
iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiiy. Iaa?oioiaaii iaoeia? aeniiaee
oa i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy
aeena?oaoe?eii? ?iaioe aeiiia?aeaeenue ? aoee iaaiai?ai? ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo i?ioani?nueei-aeeeaaeaoeueeiai neeaaeo
iaaee/iiai oaeoeueoaoo OaeAeO o 1997-1998 ??., ia i?aeia?iaeiiio
neiiic?oi?, i?aai?ciaaiiio Oai?nueeith aeaaeai??th iaoe (1997 ?.,
i.I??aaeueaaca, Oai?ueia), ia i?aeia?iaeiiio ?aa?iiaeueiiio nai?ia??
«Iaoea, oaoiieia?y, i?ia?an» (1998?., i. Oaeai?iae). Ai?iaaoe?y
aeena?oaoe?? a?aeaoeany 26 aa?aciy 1998 ?ieo ia ?icoe?aiiio can?aeaii?
eaoaae? ii?iaeueii? oa iaoieia?/ii? o?c?ieia??, aini?oaeueii?
oa?ai??, a?io?i?? oa oa?iaeieia?? iaaee/iiai oaeoeueoaoo OaeAeO.

Ioae?eaoe??. Iniiai? iieiaeaiiy aeena?oaoe?? aena?oeai? a 6 noaooyo o
oaoiaeo iaoeiaeo aeo?iaeao ? 1 oacao. 2 ?iaioe iioae?eiaai? naiino?eii.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 125
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c anooio, 5 ?icae?e?a,
a oaeiae aeniiae?a, nieneo e?oa?aoo?e, yeee neeaaeathoueny c 213
aeaea?ae oa aeiaeaoe?a. O ?iaio? i?aaenoaaeaii 7 oaaeeoeue, 8 ?enoie?a,
4 aeiaeaoee, ui caeiathoue 9 noi??iie.

INIIAIEE CIINO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeey ae??oaiiy iinoaaeaieo
caaaeaiue iaie i?iaaaeai? aeine?aeaeaiiy o aeaio a?oiao
aeine?aeaeoaaieo. O ia?oo a?oio aoiaeeei 85 i?aeoe/ii caei?iaeo
/ieia?e?a a?eii a?ae 18 aei 60 ?ie?a. Ae?oao a?oio neeaee 30
/ieia?e?a a?eii a?ae 40 aei 60 ?ie?a, oai?eo ?oai?/iith oai?iaith
na?oey ?c noaa?eueiith noaiiea?ae??th II ? III ooieoe?iiaeueieo eean?a,
o yeeo i?iaaaeaii niaeo?aeueiee aiae?c ia?oiai oiio c iaoith
aea/aiiy iiaeeeaino? ee?i?/iiai canoinoaaiiy iaoiaeo NOEA aeey
ae?aaiinoeee ii?ooaiiy eiio?aeoeeueiino? na?oeaaiai i’yca. A yeino?
eiio?ieth neoaeeee 20 i?aeoe/ii caei?iaeo /ieia?e?a aiaeia?/iiai a?eo c
ia?oi? a?oie.

Aeey aeine?aeaeaiiy i?aeae?aeenue noa’?eoe c i?eaeecii iaeiaeiaith
oiaueiith a?oaeii? no?iee aeey i?i?i?caoe?? aieeao ia
aiie?ooaeii-/anoioi? oa?aeoe?enoeee ia?oiai oiio i?ia?aeieeiaiai
na?aaeiaeua. Iiia?aaeiuei i?iaiaeeeinue o?ceeaeueia ianoaaeaiiy c
iaia’yceiaith aoneoeueoaoe??th aeey aeeeth/aiiy eeaiaiieo ii?ooaiue oa
a?oa??aeueii? a?ia?oaic??. Aeine?aeaeaiiy i?iaiaeeeinue o iieiaeaii?
«eaaea/e ia niei?» i?ney 10-15 oaeeei a?aeii/eieo aeine?aeaeoaaiiai.
I?ei?uaiiy, a yeeo i?iaiaeeeenue aenia?eiaioe, a?aeiia?aeaee
aeiiaai, ye? noaaeyoueny aei eaa?iao?a oiiiea?ae?ia?ao??
(ooiicaoeuai?noue).

Ia ia?aaeith a?oaeio no?ieo aeine?aeaeoaaiiai a ae?eyioe?
aa?o?aeiaiai iiooiaoo iaeeaaeaany eiioaeoiee aeaeo?iiaai?oiee i?e?ioii,
ui canoiniao?oueny a neeaae? aeaeo?iiiiai iie?a?aoa I4* — 01, c nioaith
a?aeoai?thaaieo /anoio 10-500 Aoe. Caien i?iaiaeeany ia i?ioyc? 10
naeoiae i?e cao?eioe? aeeoaiiy i?ney niie?eiiai aeaeeoo ? caaacia/oaaany
caioneii ia?oi? i?ia?aie, ?acoeueoaoii /iai aoa caien ioeeo?iaaiiai
oiiineaiaeo ia aei?noeee aeene o aeaeyae? oaeeo. Caione ae?oai?
i?ia?aie aeaaaa iiaeeea?noue i?aaenoaaeoe ioeeo?iaaio ?ioi?iaoe?th a
a?ao?/iiio aeaeyae? ia ae?ai? aeenieay. I?ney a?coaeueii? ioe?iee
oiiiea?ae?ia?aie eo?ni?ii o?enoaaee ii/aoie ? e?iaoeue inoeeeyoe?e
ia?oiai oiio. Caioneii o?aouei? i?ia?aie aeae?eaiee oiiineaiae
?iceeaaeaany ia /anoioiee niaeo?, yeee i?aaenoaaeyany o a?ao?/iiio oa
oeeo?iaiio aeaeyae?. O ?ic?aooiie i?eeiaeanue ona?aaeiaia aaee/eia c
i’yoe iine?aeiaieo na?oeaaeo oeeee?a. Niaeo?aeuei? ia?aiao?e ia?oiai
oiio ?ic?aoiaoaaeenue aaoiiaoe/ii o aoaeue-yeeo /anoioieo ?ioa?aaeao ye
ieiua i?ae iaeiath/ith niaeo? e?eaith ? ae?aaeaeenue a oiiaieo
iaeeieoeyo. Aaoiiaoe/ii aecia/aeanue /anoioa, ia ye?e niinoa??aaeanue
iaeneiaeueia aiie?ooaea.

Aeey ioe?iee aeeiai?ee niaeo?aeueieo neeaaeiaeo o oiae? oiio inoaii?e
?icae?eyany ia o?e ??aieo ii o?eaaeino? naaiaioe, a eiaeiiio c yeeo
i?iaaaeaii niaeo?aeueiee aiae?c.

Iaea?eueo /ooeeaee aei ?iio?iiieo aieea?a /anoioiee ?ioa?aae aecia/aany
oeyoii i?iaaaeaiiy o?ueio na??e aenia?eiaio?a. Caaaeueiee /anoioiee
?ioa?aae ia?oiai oiio (20-200 Aoe) ?icae?eyany ia o?e i?aeae?aiaciie
(20-60 Aoe, 60-100 Aoe, 100-200 Aoe) ? aei??thaaeeny i?ioeaioi?
ci?ie aia?a?? ye o caaaeueiiio ?ioa?aae?, oae ? a i?aeae?aiaciiao i?e
i?iaaaeaii? ?ciiao?e/iiai iaaaioaaeaiiy aei iiaii? aoiie oa i?e
noeioeyoe?? ia?aneiiaoe/iiai aieeao ia i?iea?ae oeyoii
i?iaaaeaiiy i?iae Aoia?a-Aeai’?i? o ?aaeei? niieith oa
?ciiao?e/iiai iaaaioaaeaiiy. Niaeo?aeuei? iieacieee niieith i?e
oeueiio neoaeeee aeaniei eiio?ieai aeey eiaeiiai aeine?aeaeoaaiiai ?
i?eeiaeenue ca 100 % . Iaaaioaaeaiiy ia i?iea?ae cae?enithaaeinue
oeyoii i?iaaaeaiiy eenoueiai? ?ciiao?e/ii? iaaaioaaeoaaeueii? i?iae
c neeith noeneaiiy aeeiaiiiao?a a 1/3 a?ae iaeneiaeueii? aei iiaii?
aoiie.

Aeey aea/aiiy caeiiii??iinoae ia?a?iciiae?eo aia?a?? o niaeo?? i?e
??cieo ?iio?iiieo noaiao o caei?iaeo in?a i?iaaaeai? iiaeaethaaiiy
nei?ioeeaino? caniaaie aieeao ia i?iea?ae /a?ac aaaaoaoeaio ia?aiao
nenoaio oa oa?iaeieia?/i? i?iae. Iaaaoeaiee ?iio?iiiee aieea ia
i?iea?ae cae?enithaaany /a?ac ia?aneiiaoe/io ia?aiao nenoaio iaoiaeii,
aeacaiei aeua.

Oa?iaeieia?/i? i?iae i?iaaaeai? c aeiiiiiaith naeaeoeaiiai
aaoa-aae?aiiaeieaoi?a Atenolol-rat?opharm 50 oa i?o?iae?oea?eio.
Aaoa-aae?aiiaeieaoi? i?eeiaany ana?aaeeio iaeii?aciai o aeic? 50 ia.
Caien oiiia?aie i?iaiaeeany aei i?eeiio i?aia?aoo, /a?ac 1 aiae. oa
ia aenio? oa?iaeieia?/ii? ae?? — /a?ac 2 aiae. I?o?iae?oea?ei
i?eeiaany noae?iaaaeueii o aeic? 0,5 ia. Caien cae?enithaaany
aaciina?aaeiuei aei i?eeiio i?aia?aoo ? /a?ac 3 oa. i?ney i?eeiio.

I?e i?iaaaeaii? aenia?eiaio?a aoei aeei?enoaii iie?ea?ae?iaiae?caoi?
IEA 4-01, ui i?aoeth? a I-?aaeei? (neaia? S?m-3000, Ioae?y).
Aeine?aeaeaiiy i?iaiaeeeiny a iieiaeaii? «eaaea/e ia niei?». Aeao/ee
?ici?uoaaany a III-IY i?ae?aaa?’? ce?aa a?ae a?oaeeie. Eieaoe?th
i?iaiaeeee a ia?o?e noaiaea?oi?e iiceoe??. I?e oeueiio ia eiaei?e
aoiea?ae?ia?ai? aei??thaaeenue e?ioeaai-ae?anoie?/iee oa
e?ioeaai-nenoie?/iee ?ici??e ii?iaeieie e?aiai oeoii/ea oa oiaueia
eiai caaeiuei? no?iee. Oe? ia?aiao?e aoee aeei?enoai? aeey io?eiaiiy
oaeeo iieaciee?a nei?ioeeaino?, ye o?aeoe?y aeeeaeo (OA, %),
nooi?iue nei?i/aiiy ia?aaeiuei-caaeiueiai ?ici??o ii?iaeieie e?aiai
oeoii/ea (% S) oa oaeaee?noue oee?eoey?iiai nei?i/aiiy aieieii
i?iea?aea (Vcf, 1/n), ye? ?ic?aoiaoaaeeny ca a?aeiieie oi?ioeaie
(Caoeeyi, 1986). Aeei?enoiaoaaeanue neio?iiia ?a?no?aoe?y
aoiea?ae?ia?ai oa oiiiea?ae?ia?ai a oiiaao o?c?ieia?/iiai niieith
aeine?aeaeoaaieo oa i?e aeeiiaii? ieie ?ciiao?e/ii? iaaaioaaeoaaeueii?
i?iae. A?oa??aeueiee oene aei??thaaany ca iaoiaeii Ei?ioeiaa,
i?ae?aoiaoaaeanue /anoioa na?oeaaeo nei?i/aiue ii ?ioa?aaeo i?ae
inoeeeyoe?yie ia?oeo oii?a OEA aai ii /anoio? a?oa??aeueiiai
ioeueno, ?ic?aoiaoaaany iiaea?eiee aeiaooie (IAe, oi. iae.) ca
oi?ioeith IAe = AOn o *NN.

Oeeo?iaee iaoa??ae ia?iaeaiee iaoiaeii aa??aoe?eii? noaoenoeee c
aeei?enoaiiyi e?eoa??th t Nouethaeaioa ca aeiiiiiaith ia?niiaeueii? AII.
A caeaaeiino? a?ae eiie?aoieo caaaeaiue aeine?aeaeaiiy aoee
aeei?enoai? iaoiaee ei?aeyoe?eiiai oa aeenia?n?eiiai aiae?co.
?ica?aeiino? i?ae aaee/eiaie, ui

ni?anoaaeyeenue, aaaaeaeenue a??ia?aeieie, yeui ? aoei iaioa 0,05.

?ACOEUeOAOE AeINEIAeAEAIIss OA ?O IAAIAI?AIIss

1. Oa?aeoa?enoeea aaee/eie oa ?iciiae?eo caoeiai? aia?a?? o niaeo??
ia?oiai oiio o caei?iaeo in?a o noai? niieith. I?e i?iaaaeaii?
niaeo?aeueiiai aiae?co o?ueio ??aieo ca o?eaae?noth naaiaio?a oiio
aeyaeaii c?inoaiiy caaaeueii? aia?a?? c iaeneioiii o oeaio?aeueiiio
naaiaio? c ianooiiei ?? cieaeaiiyi. *anoioa c iaeneiaeueiith
aiie?ooaeith aoea iaeaeuith o oeaio?aeuei?e /anoei?, i?ioa ia
ia?aaeuoaaea 30-32 Aoe. Ia i?ioyc? anueiai oiio aeii?ioaaee
iecueei/anoioi? neeaaeia?. Iaea?eueoa aia?a?y aeniei/anoioieo
neeaaeiaeo ?a?no?oaaeanue o oeaio?aeuei?e /anoei?. I/aaeaeii, o oeae
ia??iae iaeneiaeueii a?a?othoue ao??iaaio?eeoey?i? eeaiaie.
Canoinoaaiiy o eeane/i?e oiiiea?ae?ia?ao?? aeniei/anoioieo o?eueo??a
aeaei, oaeei /eiii, iniiao aeey o?aeoiaee aaaaoueia a/aieie iniiaiiai
eiiiiiaioa ye eeaiaiiiai. A?aoiaoth/e, ui OEA ?noi?e/ii ?icaeioeanue c
aoneoeueoaoe?? ? ii??a neooiaiai ni?eeiyooy a?eueo aenieee aeey
a?eueo iecueeeo /anoio, iaa?oue neeuei? a?a?aoe?? a ae?aiacii? 20-50
Aoe i?e nei?i/aii? na?oey noa’?eoeaii iiaeooue ia ni?eeiaoeny.

I?e aiae?c? niaeo??a o ?aaeei? niieith aeyaeaii iaea?eueoo ieoiio aaao
caoeiai? aia?a?? o iecueei/anoioiiio ?ioa?aae? 20-60 Aoe — 56 %4,3 %

(?en. 1). Ae?aiaciie eieeaaiue aaee/ei caoeiai? aia?a?? caoaeoaaeenue
ii i??? c?inoaiiy /anoioieo ?ioa?aae?a. Iaea?eueo? a?aeoeeaiiy
niinoa??aaeenue o iecueei/anoioiiio ae?aiacii? niaeo?a, ui, ia iaoo
aeoieo, a ia?oo /a?ao coiiaeaii ??ciith eiio?aeoeeuei?noth i?iea?aea o
??cieo in?a o caeaaeiino? a?ae aaiaoe/ii aeaoa?i?iiaaieo ??cieo oei?a
naii?aaoeyoe?? nenoaiii? aaiiaeeiai?ee.

2. Aea?? /anoioiiai ?ioa?aaeo, iaea?eueo /ooeeaiai aei ?iio?iiieo
aieea?a. I?iaaaeaii iiaeaethaaiiy ??cieo ?iio?iiieo noai?a oeyoii
aieeao ia ooieoe?iiaeueiee noai na?oeaaiai i’yca /a?ac aaaaoaoeaio
ia?aiao nenoaio. Ooo/ia cieaeaiiy eiio?aeoeeueiino? iiaeaethaaeinue
i?aeaeuaiiyi ia?aneiiaoe/ieo aieea?a ia i?iea?ae oeyoii i?iaaaeaiiy
i?iae Aoia?a — Aeai’?i?, i?aeaeuaiiy — oeyoii noeioeyoe??
neiiaoe/ieo aieea?a /a?ac i?iaaaeaiiy ?ciiao?e/iiai iaaaioaaeaiiy. O
noai? niieith i?i?iaeueia ciaioaiiy caoeiai? aia?a?? niinoa??aaeinue a
ae?aiaciiao 20-60 oa 100-200 Aoe (oaae. 1). I?e i?iaaaeaii?
?ciiao?e/ii? i?iae iaea?eueoa c?inoaiiy aia?a?? aoei o
iecueei/anoioiiio ae?aiacii? — ia 114,37,8 %. Eiee ia oii?
iaaaioaaeaiiy i?iaiaeeee i?iao Aoia?a-Aeai’?i?, oi AI*N i?aeaeuoaaeany
anueiai ia 69,2 %16,8 % ii??aiyii c? noaiii niieith aai ciaiooaaeany
ia 45,1 16,8 % ii??aiyii c? noeioeyoe??th eeoa neiiaoe/ieo aieea?a. A
?ioeo /anoioieo ?ioa?aaeao nooo?aeo ci?i i?e oeueiio ia aeyaeaii.
Iaaaoeaiee ?iio?iiiee aieea aeoeath/iai ia?aa ia oeoii/ee ?
i?i?iaeueiei o noai? niieith (I.Nia?aeae?n, 1990) ? oei a?eueoee, /ei
a?eueoa oiiiaa neiiaoe/ia aeoeai?noue. Ci?ie AI*N i?e i?iaaaeaii? oeeo
aenia?eiaio?a ia caaaeaee ei?aethaaee ?c ci?iaie aia?a?? a ?ioeo
/anoioieo ?ioa?aaeao.

Oaeei /eiii, iaea?eueo oi/iei ? /ooeeaei ae?aiaciiii aei ?iio?iiieo
aieea?a ? iecueei/anoioiee.

3. Aca?iica’ycie i?ae aia?a??th iecueeeo /anoio ia?oiai oiio oa
iieacieeaie nei?ioeeaino? ca aeaieie I-aoiea?ae?ia?ao??. Ianooii?
aeine?aeaeaiiy aoee ni?yiiaai? ia anoaiiaeaiiy aca?iica’yceo i?ae AI*N
oa iieacieeaie nei?ioeeaino? ca aeaieie I-aoiea?ae?ia?ao??: o?aeoe??th
aeeeaeo, nooiaiai nei?i/aiiy ia?aaeiuei-caaeiueiai ?ici??o ii?iaeieie
e?aiai oeoii/ea oa oaeaee?noth oee?eoey?iiai nei?i/aiiy aieieii
i?iea?aea. I?e oeueiio iaeneaaoee i?yiee ei?aeyoe?eiee ca’ycie
anoaiiaeaii i?ae AI*N oa OA (r = 0,326, ?<0,05), ? a ii?yaeeo c?inoaiiy - i?ae AI*N oa % S (r = 0,354, ?<0,01), oa i?ae AI*N ? Vcf (r = 0,392, P<0,01). Ne?ae caoaaaeeoe, ui aea?ai? aoiea?ae?ia?ao?/i? iieacieee nei?ioeeaino? a iniiaiiio oa?aeoa?ecothoue eiio?aeoeeuei?noue i?iea?aea i?ae /an ia??iaeo aeaiaiiy e?ia? ? caeaaeaoue a?ae oiia iaaaioaaeaiiy, a iniiaia aaee/eia aia?a?? ia?oiai oiio i?eiaaea? ia ia??iae ?ciaiethi?/iiai nei?i/aiiy. Ca?eueoaiiy iinoiaaaioaaeaiiy ia i?iea?ae i?e i?iaaaeaii? ?ciiao?e/ii? i?iae aeiaaa? o a?eueo?e i??? caa?aaeaiiy iiia?aaeiueiai nenoie?/iiai ia'?io, i?ae eiai ca?eueoaiiy. A?aoiaoth/e, ui e?ioeaaee ae?anoie?/iee ia'?i o caei?iaeo in?a i?e oeueiio nooo?ai ia ci?iththoueny, cia/aiiy o?aeoe?? aeeeaeo caeeoathoueny oaeeie ae, ye ? o noai? niieith aai iacia/ii ca?eueoothoueny. Iaeneeuei?oee ei?aeyoe?eiee ca'ycie i?ae AI*N oa Vcf, i/aaeaeii, o a?eueo?e i??? coiiaeaiee oei, ui i?e i?aeaeuaii? eiio?aeoeeueiino? o caei?iaeo in?a nei?i/othoueny ia??iae aeaiaiiy e?ia?. I?e??no AI*N o oiae? ca?eueoaiiy iinoiaaaioaaeaiiy ia i?iea?ae aei iiaii? aoiie a iaai?e i??? aea? iiaeeea?noue ioe?ithaaoe eiio?aeoeeueiee ?aca?a na?oeaaiai i'yca eiie?aoiiai ?iaeea?aea. 4. Aeyaeaiiy oi?o?eiaaieo niaeo?aeueieo e?eoa???a nei?ioeeaino?. Aeey iiooeo oi?o?eiaaieo niaeo?aeueieo e?eoa???a nei?ioeeaino? aea/aeenue caeiiii??iino? ia?a?iciiae?eo aia?a?? o niaeo?? a caeaaeiino? a?ae ??cieo ?iio?iiieo noai?a. Inoaii? iiaeaethaaeenue ye o?c?ieia?/iei (?ciiao?e/ia iaaaioaaeaiiy aei iiaii? aoiie ), oae ? oa?iaeieia?/ieie niiniaaie (i?eeiiii aaoa-aae?aiiaeieaoi?a Atenolol-rat?opharm 50 oa i?o?iae?oea?eio). I?e ?ciiao?e/iiio iaaaioaaeaii? a?aei?/ai? ianooii? ci?ie o ?iciiae?e? aia?a?? a niaeo??: ia?aaaaeia c?inoaiiy AI*N ii??aiyii c aia?a??th a ?ioeo /anoioieo ae?aiaciiao (100 % aeiaaee?a); ia?ai?uaiiy i?aai? iniiae iniiaiiai i?ea o a?e a?eueo aenieeo /anoio (100 %). O 98% aeiaaee?a c?inoaea aiie?ooaea iaeneiaeueii? /anoioe, o 30 % ae?aeo aa?oeie iniiaiiai i?ea o a?e a?eueo aenieeo /anoio ia 2-4 Aoe. I?e i?iaaaeaii? oa?iaeieia?/ieo i?ia, ui aeeeeeathoue cieaeaiiy eiio?aeoeeueiino? /a?ac aieea ia iae?iaaii? oa i?iaaii? iaoai?cie ?aaoeyoe??, aeeiai?ea /anoioiiai niaeo?a oa?aeoa?ecoaaeanue ci?iaie, i?ioeeaaeieie aei oeo, ui niinoa??aaeenue i?e ca?eueoaii? eiio?aeoeeueiino?, a naia: ia?aaaaeiei cieaeaiiyi AI*N ii??aiyii c aeeiai?eith a ?ioeo /anoioieo ?ioa?aaeao, ia?ai?uaiiyi i?aai? /anoeie iniiaiiai i?ea oa aiie?ooaee iaeneiaeueii? /anoioe o a?e a?eueo iecueeeo /anoio. Oe? iniaeeaino? ia?a?iciiae?eo aia?a?? o neeaae? oiio oa o iecueei/anoioiiio ?ioa?aae? aeaee iniiao aeey aeae?eaiiy oi?o?eiaaieo iieaciee?a - a?aeiioaiiy aia?a?? ae?aiaciio 20-60 Aoe aei aiaeia?/iiai ca oe?eiith ae?aiaciio 60-100 Aoe (A 20-60/60-100) oa i?ioeaio aia?a?? iniiaiiai i?ea o neeaae? AI*N (% S i?ea), ye?, ia iaoo aeoieo, a iaio?e i??? caeaaeaoue a?ae i?ia?aeieeiaiai na?aaeiaeua, i?ae aaee/eie AI*N. I?aeaeuaiiy eiio?aeoeeueiino? i?iea?aea i?e i?iaaaeaii? ?ciiao?e/iiai iaaaioaaeoaaeueiiai oanoo aeinyaathoueny iineeaiiyi neiiaoiaae?aiaeiaeo aieea?a, ? a cia/ii iaio?e i??? - ca?eueoaiiyi *NN (aiia c?inoa? ia 9-10 % o caei?iaeo). I'ycia? aieieia i?e nei?i/aii? aaia?othoue iecuee? /anoioe. Ine?eueee iaea?eueo cia/iei aeaea?aeii a?a?aoe?? ? i?iea?ae, oi iecueei/anoioi? oaee?, iaeeaaeath/enue iaeia ia iaeio, noai?ththoue iaeneioi caoeiai? aia?a?? o iecueei/anoioiiio ?ioa?aae?. Eiia??ii, ui /anoioa, ia ye?e o?eno?oueny iaeneiaeueia aiie?ooaea, icia/a?, ui naia ia oe?e /anoio? a?aeaoeany iaea?eueoa e?euee?noue ni?aiaae?iue ii oac? oe??? /anoioe, oiaoi iaeneioi o niaeo?? i?eiaaea? ia iaea?eueo ?aciiainio /anoioo. A?aeiii, ui ?nioth iaaiee o?c?ieia?/iee aneio?ii?ci o aeeth/aii? ie?aieo aieieii o nei?ioeeaee i?ioean (O.A.Aeyoiai oa ?i., 1989). Iaeii/ania nei?i/aiiy aeaio aieieii aeanoue a?eueoo ?acoeueooth/o neeo, ? /ei a?eueoee cnoa ii oac? i?ae ii/aoeii nei?i/aiiy aieieii, oei ?acoeueooth/a neea iaioa. Ca?aene aeieeaa?, ui nooi?iue aneio?ii?cio i?e nei?i/aii? i?iea?aea aecia/a? oaeaee?noue c?inoaiiy iai?oaeaiiy ? neeo nei?i/aiiy. Iniaeeaiai cia/aiiy oaeoi? aneio?ii?cio iaaoaa? i?e iaoieia?? i?iea?aea, eiee nooi?iue eiai cia/ii c?inoa?. O ee?i?/ieo oiiaao aecia/aoe eiai aeoaea aaaeei, ine?eueee o?aaeeoe?ei? iaoiaee aeathoue ?ioaa?aeueio ioe?ieo nei?ioeeaino? ia i?aaiiiio ??ai?. I?e ca?eueoaii? eiio?aeoeeueiino? ca?eueoothoueny oaeaee?noue nei?i/aiiy o ??cieo a?aeae?eao i?iea?aea ? ciaioo?oueny nooi?iue aneio?ii?cio o aeeth/aii? i'yciaeo aieieii o nei?ioeeaee i?ioean. Oea i?ecaiaeeoue aei ciaioaiiy oaciaeo cnoa?a iaoai?/ieo eieeaaiue, ye? i?e oeueiio aeieeathoue, ? aei ca?eueoaiiy ?aciiaino. I/aaeaeii, oiio ? niinoa??aa?oueny ia?aaaaeia c?inoaiiy caoeiai? aia?a?? o ae?aiacii? iecueeeo /anoio. 5. Ioe?iea ee?i?/ii? ?ioi?iaoeaiino? niaeo?aeueieo iieaciee?a ia?oiai oiio aeey ae?aaiinoeee ii?ooaiiy eiio?aeoeeueiino? o oai?eo ?oai?/iith oai?iaith na?oey. C iaoith ia?aa??ee ?ioi?iaoeaiino? niaeo?aeueieo iieaciee?a aeey ae?aaiinoeee iaiaaeaiiy eiio?aeoeeueiiai ?aca?ao i?e i?iea?ae?aeuei?e iaoieia?? aoee i?iaaaeai? aeine?aeaeaiiy 30 oai?eo c ee?i?/ii ae?aaiinoiaaiith ?oai?/iith oai?iaith na?oey c? noaiiea?ae??th II oa III ooieoe?iiaeueieo eean?a. Aeae?ath/e aeaio iicieia?th, ie aeoiaeeee c oeo i??eoaaiue, ui e??i cieaeaiiy eiio?aeoeeueiiai ?aca?ao aiane?aeie neea?ioe/ieo oa aeeno?io?/ieo ci?i o i?iea?ae?, ca?eueoaiiy iinoiaaaioaaeaiiy aoaea i?iaieoaaoe ii?ooaiiy ei?iia?iiai e?iaioieo a o?aaeaieo ei?iia?ieo a?oa??yo ? aeeeth/aiiy ?oai?ciaaiiai ?aa?iio i?iea?aea ?c nei?ioeeaiai i?ioeano. I?e ni?anoaaeaii? o noai? niieith iieaciee?a AI*N, a?aeiioaiiy A 20-60/60-100, % S i?ea o oai?eo c aiaeia?/ieie iieacieeaie o caei?iaeo ia aeyaeaii aeinoia??ieo a?aei?iiinoae (oaae. 2). Niinoa??aaeany eeoa oaiaeaioe?y aei cieaeaiiy ?o o a?oi? oai?eo. Ca?eueoaiiy iinoiaaaioaaeaiiy ia i?iea?ae aeyaeei aeinoia??i? a?aei?iiino? o aeeiai?oe? oeeo iieaciee?a. O 73,3 % aeiaaee?a o a?oi? oai?eo niinoa??aaeinue cieaeaiiy ?o ii??aiyii ?c noaiii niieith, o 13,3 % iieacieee caeeoeeeny i?aeoe/ii aac ci?i, ? a 13,3 % iacia/ii c?inee, a oie /an ye o a?oi? caei?iaeo niinoa??aaany i?e??no o 100 % aeiaaee?a. Caa?aaeaiiy aaee/eie AI*N o iaaeao ii?ie a noai? niieith o oai?eo ION iiaeia iiynieoe aeeth/aiiyi ??cieo iaoai?ci?a eiiiainaoe?? aioo??oiueina?oeaai? aaiiaeeiai?ee, ye? a oiiaao neea?ioe/ieo ? aeeno?io?/ieo ci?i caaacia/othoue iaiao?aeio neeo nei?i/aiiy. I?ioa i?e iaaaioaaeaii? eiiiainaoi?i? ?aca?ae oaeaeei ae/a?iothoueny ? na?oea noa? iani?iiiaeiei caaacia/eoe iaeaaeiee nenoie?/iee ia'?i e?ia?, ui i?ecaiaeeoue aei oaeiai ia?a?icoyaiaiiy i'yciaeo aieieii ca?eueoaieie e?ioeaaei ae?anoie?/iei ia'?iii ? oeneii, ui cieaeothoueny oaeaee?noue ? neea na?oeaaiai nei?i/aiiy. I/aaeaeii, oiio ? cieaeoaaeenue o a?eueoino? oai?eo niaeo?aeuei? iieacieee ia?oiai oiio i?e ?ciiao?e/iiio iaaaioaaeaii?. AENIIAEE 1. Iaoiae niaeo?aeueii? oiiiea?ae?ia?ao?? aeicaiey? i?iaanoe ?a?no?aoe?th caoeiaeo eieeaaiue i?iea?ae?aeueiiai iioiaeaeaiiy ? a?aeaeeoa?aioe?thaaoe ?o a?ae a?a?aoe?e eeaiaiiiai aaiaco. 2. Oeyoii aiae?co /aniai? aeeiai?ee niaeo?aeueieo neeaaeiaeo ia?oiai oiio anoaiiaeaii, ui eiai i'yciaee eiiiiiaio a?aeiineoueny ia eeoa aei ?i?oe?aeueieo (ii/aoeiaeo) a?a?aoe?e, aea e aeii?io? a iniiai?e /anoei? oiio. 3. Anoaiiaeaii, ui iaea?eueo /ooeeaei aei ci?i nei?ioeeaino? i?iea?aea o caaaeueiiio /anoioiiio ae?aiacii? ia?oiai oiio ? iecueei/anoioiee ?ioa?aae 20-60 Aoe, ui i?aeoaa?aeaeo? a?iioaco i?i eiai i'yciaa iioiaeaeaiiy. 4. Aeyaeaii i?yiee iiceoeaiee ei?aeyoe?eiee ca'ycie na?aaeiuei? neee i?ae aia?a??th iecueei/anoioieo (i'yciaeo) a?a?aoe?e oa iieacieeaie nei?ioeeaino? ca aeaieie I-aoiea?ae?ia?ao??: o?aeoe??th aeeeaeo (r = 0,326, P<0,05), nooiaiai nei?i/aiiy ia?aaeiuei-caaeiueiai ?ici??o ii?iaeieie e?aiai oeoii/ea (r = 0,354, ?<0,01) oa oaeaee?noth oee?eoey?iiai nei?i/aiiy aieieii i?iea?aea (r = 0,392, ?<0,01). 5.Anoaiiaeaii, ui /ooeea?noue iieacieea aia?a?? iecueeeo /anoio (AI*N) ia?oiai oiio aei ci?i eiio?aeoeeueiino? i?iea?aea i?e i?iaaaeaii? ?ciiao?e/iiai iaaaioaaeoaaeueiiai oanoo aei iiaii? aoiie ? cia/ii a?eueoith ii??aiyii c /ooeea?noth iieaciee?a nei?ioeeaino? ca aeaieie I-aoiea?ae?ia?ao?? (OA, % S, Vcf). 6.Ae?iaeai? oi?o?eiaai? niaeo?aeuei? iieacieee nei?ioeeaino?, ye? i?i?iaeueii caeaaeaoue a?ae i?ia?aeieeiaiai na?aaeiaeua ? iaeneiaeueii - a?ae noaio nei?ioeeaino? na?oeaaiai i'yca: a?aeiioaiiy aia?a?? iecueei/anoioiiai ?ioa?aaeo 20-60 Aoe aei aiaeia?/iiai ca oe?eiith ?ioa?aaeo 60-100 Aoe (A 20-60/60-100); i?ioeaioia /anoea aia?a?? iniiaiiai icueei/anoioiiai i?ea a iaaeao ?ioa?aaeo 20-60 Aoe (% S i?ea). 7. Ni?anoaaeaiiy aeeiai?ee niaeo?aeueieo iieaciee?a o caei?iaeo oa ooai?eo ?oai?/iith oai?iaith na?oey c noaiiea?ae??th II-III ooieoe?iiaeueieo eean?a i?e i?iaaaeaii? ?ciiao?e/iiai iaaaioaaeoaaeueiiai oanoo iieacaei, ui o a?oi? oai?eo o 73,3 % aeiaaee?a niaeo?aeuei? iieacieee cieaeoaaeenue ii??aiyii c? noaiii niieith, o 13,3 % aiie caeeoeeenue i?aeoe/ii aac ci?i ? o 13,3 % aeiaaee?a niinoa??aaany ?o iacia/iee i?e??no, ui na?ae/eoue i?i aeioe?euei?noue canoinoaaiiy iaoiaeeee aeey ioe?iee iaiaaeaiiy eiio?aeoeeueiiai ?aca?ao i?e i?iea?ae?aeuei?e iaoieia??. I?AEOE*I? ?AEIIAIAeAOe?? 1. C iaoith io?eiaiiy aiie?ooaeii-/anoioii? oa?aeoa?enoeee ia?oiai oiio aeioe?eueii aeei?enoiaoaaoe eiii'thoa?iee niaeo?aeueiee aiae?c oiiineaiaeo oiio, caienaiiai ca aeiiiiiaith eiioaeoiiai aeaeo?iiaai?oiiai i?e?ioiia c iiaa?oi? a?oaeii? ee?oeie. Cai?iiiiiaaia aeie-noaia eiii'thoa?ii? onoaiiaee oa i?ia?aiia caaacia/aiiy c canoinoaaiiyi oaeaeeiai ia?aoai?aiiy Oo?'?. Iioi?iaoeaieie ae?eyieaie niaeo?a ? ae?aiacii /anoio 20-60 Aoe oa 60-100 Aoe. 2. Aeey ia'?eoeaii? ?ino?oiaioaeueii? ioe?iee ooieoe?iiaeueiiai noaio i?iea?aea aeioe?eueii aecia/aoe oae? niaeo?aeuei? iieacieee oiio ye: aia?a?y ae?aiaciio 20-60 Aoe, a?aeiioaiiy A 20-60/60-100, i?ioeaioia /anoea aia?a?? iniiaiiai i?ea a iaaeao ae?aiaciio 20-60 Aoe (% S i?ea). Ca ii?ie ne?ae i?eeiaoe ianooii? cia/aiiy oeeo iieaciee?a: 2747,8 o.i., 2,50,05 oa 65,20,68. Nooi?iue c?inoaiiy ?o i?e i?iaaaeaii? ?ciiao?e/iiai iaaaioaaeoaaeueiiai oanoo aei iiaii? aoiie ? i??ith eiio?aeoeeueiiai ?aca?ao i?iea?aea; cieaeaiiy ?o a ?aaeei? iaaaioaaeaiiy na?ae/eoue i?i nooo?aa iaiaaeaiiy ooieoe?iiaeueiiai ?aca?ao na?oeaaiai i'yca. 3. Aeaia iaoiaeeea iiaea aooe aoaeoeaii aeei?enoaia a nii?o? aeey ioe?iee aaeaeaaoiino? o?aioaaeueiiai ?aaeeio (cieaeaiiy niaeo?aeueieo iieaciee?a nei?i/aiiy o noai? niieith oa ca?eueoaiiy i?e?inoo a ?aaeei? iaaaioaaeaiiy); ye aeiaeaoeiaee ?ino?oiaioaeueiee iaoiae aeey ae?aaiinoeee aeeno?io?? i?iea?aea aiane?aeie o?ce/iiai ia?aiaaaioaaeaiiy. NIENIE IIOAEIEIAAIEO I?AOeUe CA OAIITH AeENA?OAOeI? 1. Oaeaoa A.I., E?aaaeae? E.A., Uiaae I.I., ssnai/ae N.A., ?aeei I.TH. Ae?aaiinoeea aeeno?io?? i?iea?aea aiane?aeie o?ce/iiai ia?aiaaaioaaeaiiy o nii?oniai?a ca aeaieie niaeo?aeueii? oiiiea?ae?ia?ao?? // Iaoeiaee a?niee Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo. - Na??y "Iaaeeoeeia". - Oaeai?iae, 1995. N. 81-84. 2. Uiaae I.I. Iia? iiaeeeaino? canoinoaaiiy niaeo?aeueiiai aiae?co ia?oiai oiio na?oey aeey ioe?iee ooieoe?? i?iea?aea // Iaoeiaee a?niee Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo. - Na??y "Iaaeeoeeia". - Oaeai?iae, 1996. N. 286-288. 3. Uiaae I.I., Ae/ei I.A., ?aoi/ea ss.A., Naaea TH.I., Oeyiaoeue N.A. Iiaeaethaaiiy aieeao aaaaoaoeaii? ia?aiai? nenoaie ia ooieoe?iiaeueiee noai i?iea?aea ca aeaieie niaeo?aeueiiai aiae?co ia?oiai oiio // Iaoeiaee a?niee Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo. - Na??y "Iaaeeoeeia". - Oaeai?iae, 1997. - N. 189-190. 4. Uiaae I.I. Aeeiai?ea niaeo?aeueii? aia?a?? ia?oiai oiio na?oey o caei?iaeo in?a i?ae ae??th ?ciiao?e/iiai iaaaioaaeaiiy // Iaoeiaee a?niee Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo. - Na??y "Iaaeeoeeia". - Oaeai?iae, 1997. - N. 218-219. 5. Naaea TH.I., Oeyiaoeue N.A., ?aoi/ea ss.A., Uiaae I.I., Oaeaoa A.I. Nei?ioeeaa ooieoe?y i?iea?aea a caei?iaeo ethaeae a caeaaeiino? a?ae oeio naii?aaoeyoe?? e?iaiia?ao // Iaoeiaee a?niee Oaeai?iaenueeiai oi?aa?neoaoo. - Na??y "Iaaeeoeeia".- Oaeai?iae, 1997.- N. 144-146. 6. Naaea TH.I., Oeyiaoeue N.A., ?aoi/ea ss.A., Uiaae I.I., Oaeaoa A.I. Iaoiaeeea ?ioaa?aeueii? ioe?iee aaiiaeeiai?ee ca oeiaie naii?aaoeyoe?? e?iaiia?ao // Iaoeiaee a?niee Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo. Na??y "Iaaeeoeeia". - Oaeai?iae, 1998. - N. 104-105. 7. Fabry Z., Feketa V., Schobak A., Zajacsuk I. Az elso sz?vhang spektral?s karakter?szt?kaja es annak elvaltozasa terheles? probak hatasara /Eve tudomanyos ulesen elhangzott eloadasok oszefoglalo?. Ny?redyhasa, 1996. - c. 218. AIIOAOeIss Uiaae I.I. Niaeo?aeuei? oa?aeoa?enoeee ia?oiai na?oeaaiai oiio ye ia?ea? ooieoe?iiaeueiiai noaio i?iea?aea. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoeca niaoe?aeuei?noth 14.03.03 - ii?iaeueia o?c?ieia?y. - Iinoeooo aa?iioieia?? AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?th i?enay/aii aeine?aeaeaiith aiie?ooaeii-/anoioieo oa?aeoa?enoee ia?oiai na?oeaaiai oiio c iaoith ?ic?iaee e?eoa???a ioe?iee ooieoe?iiaeueiiai noaio na?oeaaiai i'yca. Aia?oa aeyaeaii, ui iaea?eueo /ooeeaei /anoioiei ?ioa?aaeii o no?oeoo?? oiio aei ?iio?iiieo aieea?a th iecueei/anoioiee ae?aiacii (20-60 Aoe). Anoaiiaeaii, ui /ooeea?noue aaee/eie aia?a?? iecueeeo /anoio aei ci?i nei?ioeeaino? i?e i?iaaaeaii? ?ciiao?e/iiai iaaaioaaeoaaeueiiai oanoo ? cia/ii a?eueoith ii??aiyii c /ooeea?noth iieaciee?a nei?ioeeaino? ca aeaieie I-aoiea?ae?ia?ao??. Cai?iiiiiaaii aeinooiio aeniei/ooeeao iaoiaeeeo ioe?iee eiio?aeoeeueiiai ?aca?ao i?iea?aea ca aeiiiiiaith iaoiaeo niaeo?aeueii? oiiiea?ae?ia?ao??. ?ic?iaeai? oi?o?eiaai? niaeo?aeuei? iieacieee nei?ioeeaino?, ui i?i?iaeueii caeaaeaoue a?ae ia?aiao??a i?ia?aeieeiaiai na?aaeiaeua. Iieacaii aenieo ?ioi?iaoeai?noue iaoiaeo NOEA aeey ioe?iee iaiaaeaiiy eiio?aeoeeueiiai ?aca?ao i?e i?iea?ae?aeuei?e iaoieia??. Eeth/ia? neiaa: ia?oee oii na?oey, niaeo?aeueiee aiae?c, ?ciiao?e/ia iaaaioaaeaiiy, eiio?aeoeeueiee ?aca?a. AIIIOAOeEss Uiaae A.E. Niaeo?aeueiua oa?aeoa?enoeee ia?aiai na?aea/iiai oiia eae ia?ea? ooieoeeiiaeueiiai ninoiyiey ieiea?aea. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.03. - ii?iaeueiay oeceieiaey. Einoeooo aa?iioieiaee AII Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia enneaaeiaaieth aiieeooaeii-/anoioiuo oa?aeoa?enoee ia?aiai na?aea/iiai oiia n oeaeueth ?ac?aaioee e?eoa?eaa ioeaiee ooieoeeiiaeueiiai ninoiyiey na?aea/iie iuooeu. Eae ecaanoii, a ninoaaa ia?aiai na?aea/iiai oiia eiaaony oae iacuaaaiue iuoa/iue eiiiiiaio. N oi/ee c?aiey aeioece/aneie aea?aoeeiiiie aeiioacu a iniiaa ieiea?aeeaeueiuo caoeia eaaeao aneio?iiiua eieaaaiey iuoa/iuo aieieii ai a?aiy nie?auaiey. Niaeanii aeaiiuo iineaaeieo enneaaeiaaiee, /anoioiue eioa?aae 20-60 Aoe yaeyaony eiaiii ieiea?aeeaeueiiai i?ienoiaeaeaiey. Ionthaea auoaeaao ?aai/ay aeiioaca i oii, /oi aai ia?aiao?u iiaeii eniieueciaaoue aeey oa?aeoa?enoeee iniaaiiinoae no?oeoo?u na?aea/iie iuooeu a nayce n nie?aoeiinoueth. Aianoa n oai aieueoeinoai enneaaeiaaoaeae n/eoatho iuoa/iua eieaaaiey ieceiaiieeooaeiuie e naycuaatho eo aeaaiui ia?acii n eieoeeaeueiuie aea?aoeeyie ia?aiai oiia, a iniiaioth oeaio?aeueioth /anoue ioiinyo e aea?aoeeyi noai?/aouo eeaiaiia. Iaeiaei i?e i?iaaaeaiee niaeo?aeueiiai aiaeeca ioia/aii, /oi iaeneioi caoeiaie yia?aee iaoiaeeony a iecei/anoioiii eioa?aaea. Oeaeueth aeaiiie ?aaiou auei onoaiiaeaiea eioi?iaoeaiuo e?eoa?eaa aiieeooaeii-/anoioiie oa?aeoa?enoeee ia?aiai oiia, eioi?ua ioia?aaeaee au eiio?iiiia ninoiyiea ieiea?aea, e eco/aiea aiciiaeiinoe eo eniieueciaaiey aeey ioeaiee ooieoeeiiaeueiiai ninoiyiey na?aea/iie iuooeu a oeceieiae/aneeo oneiaeyo, a oaeaea i?e ieiea?aeeaeueiie iaoieiaee. Aeey aeinoeaeaiey yoie oeaee ?aoaeenue iniiaiua caaea/e: 1. ?ac?aaioea aaoiiaoece?iaaiiie onoaiiaee, eioi?ay iicaieyea au iieo/aoue /anoioiue niaeo? ia?aiai oiia, au/eneyoue ioiineoaeueioth caoeiaoth yia?aeth a ethaii /anoioiii eioa?aaea a i?aaeaeao enneaaeoaiiai /anoioiiai aeeaiaciia. 2. Iaia?oaeaiea /anoioiiai eioa?aaea, iaeaieaa /oanoaeoaeueiiai e eciaiaieyi nie?aoeiinoe ieiea?aea. 3. Niiinoaaeaiea aaee/eiu yia?aee iaeaieaa /oanoaeoaeueiuo e eiio?iiiui aicaeaenoaeyi iecei/anoioiuo ninoaaeythueo oiia n iieacaoaeyie nie?aoeiinoe ii aeaiiui I-yoiea?aeeia?aoee aeey onoaiiaeaiey iaee/ey e oa?aeoa?a acaeiinaycae iaaeaeo ieie. 4. Onoaiiaeaiea caeiiiia?iinoae ia?a?ani?aaeaeaiey caoeiaie yia?aee a /anoioiii aeeaiaciia oiia a caaeneiinoe io eiio?iiiiai ninoiyiey ieiea?aea aeey au?aaioee oieoeoee?iaaiiuo niaeo?aeueieo iieacaoaeae nie?auaiey. 5. Ioeaiea eeeie/aneie eioi?iaoeaiinoe niaeo?aeueiuo iieacaoaeae ia?aiai oiia aeey aeeaaiinoeee ia?ooaiey eiio?aeoeeueiinoe o aieueiuo eoaie/aneie aieaciueth na?aeoea. Enneaaeiaaiey i?iaaaeaiu ia 85 i?aeoe/anee caei?iauo ioae/eiao aic?anoii io 18 aei 60 eao, a oaeaea ia 30 aieueiuo EAN ni noaaeeueiie noaiiea?aeeae II ? III ooieoeeiiaeueiuo eeannia aic?anoii io 40 aei 60 eao. A ?aaioa eniieueciaai iaoiae niaeo?aeueiiai aiaeeca oiiiea?aeeia?aiiu n iiiiuueth eiiiuethoa?iie oaoieee. ?ani?aaeaeaiea yia?aee a /anoioiii niaeo?a oiia eco/aeinue a ?aaeeiai iieiy, ai a?aiy i?iaaaeaiey eciiao?e/aneie iaa?oci/iie i?iau, a oaeaea i?e i?iaaaeaiee oa?iaeieiae/aneeo aicaeaenoaee. A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee onoaiiaeaii, /oi iuoa/iue eiiiiiaio ia?aiai oiia aeiieie?oao a iniiaiie /anoe oiia; iaeaieaa /oanoaeoaeueiui e eciaiaieyi nie?aoeiinoe ieiea?aea yaeyaony iecei/anoioiue eioa?aae 20-60 Aoe, /oi iiaeoaa?aeaeaao aeiioaco i aai iuoa/iii i?ienoiaeaeaiee; iaia?oaeaii iieiaeeoaeueioth ei??aeyoeeiiioth naycue n?aaeiae neeu iaaeaeo yia?aeae iecei/anoioiuo aea?aoeee e iieacaoaeyie nie?aoeiinoe ii aeaiiui I-yoiea?aeeia?aoee: o?aeoeeae aua?ina (r = 0,326, P<0,05), noaiaiueth oei?i/aiey ia?aaeia-caaeiaai ?acia?a iieinoe eaaiai aeaeoaei/ea (r = 0,354, ?<0,01) e nei?inoueth oee?eoey?iiai oei?i/aiey aieieii ieiea?aea (r = 0,392, ?<0,01). Onoaiiaeaii, ui /oanoaeoaeueiinoue iieacaoaey yia?aee ieceeo /anoio ia?aiai oiia e eciaiaieyi eiio?aeoeeueiinoe ieiea?aea i?e i?iaaaeaiee eciiao?e/aneiai iaa?oci/iiai oanoa yaeyaony cia/eoaeueii aieueoae ii n?aaiaieth n /oanoaeoaeueiinoueth iieacaoaeae nie?aoeiinoe ii aeaiiui I-yoiea?aeeia?aoee (OA, % S, Vcf). ?ac?aaioaiu oieoeoee?iaaiiua niaeo?aeueiua iieacaoaee nie?aoeiinoe: ioiioaiea yia?aee iecei/anoioiiai eioa?aaea 20-60 Aoe e aiaeiae/iiio ii oe?eia eioa?aaeo 60-100 Aoe (Y 20-60/60-100); i?ioeaio yia?aee iniiaiiai ieea a i?aaeaeao eioa?aaea 20-60 Aoe (% S ieea). I?aaeeiaeaia aeinooiiay auniei/oanoaeoaeueiay iaoiaeeea ioeaiee eiio?aeoeeueiiai ?aca?aa ieiea?aea n iiiiuueth iaoiaea niaeo?aeueiie oiiiea?aeeia?aoee. Iieacaia aunieay eioi?iaoeaiinoue iaoiaea aeey ioeaiee ia?aie/aiey eiio?aeoeeueiiai ?aca?aa i?e ieiea?aeeaeueiie iaoieiaee. Eeth/aaua neiaa: ia?aue oii na?aeoea, niaeo?aeueiue aiaeec, eciiao?e/aneay iaa?ocea, eiio?aeoeeueiue ?aca?a. SUMMARY Shchobak A.I. Spectral character?st?cs of the f?rst heart sound as a marker of the funct?onal state of the myocard. - Manuscr?pt. Thes?s for sc?ent?f?c degree of the master of med?c?ne by spec?al?ty 14.03.03 - normal ph?s?ology. - The Gerontology Inst?tute of the Academy of Med?cal Sc?ences of Ukra?ne, Ky?v, 1999. The d?ssertat?on ?s ded?cated to ?nvest?gat?on of the f?rst card?al sound ampl?tude-frequency character?st?cs. The a?m of the study was to evaluate cr?ter?a of the card?al muscle funct?onal state. For the f?rst t?me ?t has been determ?ned, that the low frequency range (20-60 Hz) ?s the most sens?t?ve to the ?notrop?c ?nfluences. It was est?mated, that the sens?t?l?ty of the low frequency energy to the changes of contract?v?ty dur?ng the ?sometr?c load test ?s essent?ally greater, than the sens?t?v?ty of the contract?l?ty data obta?ned by M-echocard?ograph?c method. H?ghly sens?t?ve, s?mple method for evaluat?on of contract?l?ty reserve by the spectral phonocard?ography has been proposed. Un?f?ed spectral data of contract?l?ty have been elaborated w?th m?n?mum dependence on the parameters of the conduct?ve med?a. H?gh ?nformat?on capab?l?ty of the method for contract?l?ty reserve restr?ct?on evaluat?on has been shown. Key words: f?rst heart sound, spectral analys?s, ?sometr?c load test, contract?l?ty reserve.

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