19

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

?i. Aeaieea aaeeoeueeiai

_____________________________________________________________________

1. Ia i?aaao ?oeiieno

Oia?aaea ss?eia Aiaaeai?aia

OAeE 615.31:547.789].012.015.3

Neioac, ia?aoai?aiiy oa a?ieia?/ia aeoeai?noue iae?iaaoa?ioeeee?/ieo
niieoe ia iniia? o?acie?aeiio-4

15.00.02 — oa?iaoeaaoe/ia o?i?y oa oa?iaeiaiic?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa oa?iaoeaaoe/ieo iaoe

Euea?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? oa?iaoeaaoe/ii?, i?aai?/ii? oa a?ii?aai?/ii?
o?i?? Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea
Aaeeoeueeiai IIC Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? oa?iaoeaaoe/ieo iaoe, i?ioani?

Ioce/aiei Aieiaeeie? Iaianiae/,
Euea?anueeee aea?aeaaiee

iaaee/iee oi?aa?neoao ?i. Aeaieea
Aaeeoeueeiai, i?ioani? eaoaae?e

oa?iaoeaaoe/ii?, i?aai?/ii? oa
a?ii?aai?/ii? o?i??.

Io?oe?ei? iiiiaioe: aeieoi? o?i?/ieo iaoe, i?ioani?

Iia?eia Aieiaeeie? Iaaeiae/,
Aea?aeaaiee oi?aa?neoao

«Euea?anueea iie?oaoi?ea»,
caa?aeoaa/ eaoaae?ith oaoiieia??

a?ieia?/ii aeoeaieo ?a/iaei,
iai?ai?iaeoeo?a oa aa?aiee?a;

eaiaeeaeao oa?iaoeaaoe/ieo iaoe,

*aaai ?ai? A?eai?iae/,
Euea?anueeee aea?aeaaiee iaaee/iee

oi?aa?neoao ?i. Aeaieea
Aaeeoeueeiai, noa?oee aeeeaaea/ eaoaae?e

oa?iaoeaaoe/ii? o?i?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe.

I?ia?aeia onoaiiaa: Iaoe?iiaeueia oa?iaoeaaoe/ia aeaaeai?y IIC Oe?a?ie
(i.Oa?e?a)

Caoeno a?aeaoaeaoueny 11.04.2000?. i 13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 35.600.02 o Euea?anueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? ?i. Aeaieea Aaeeoeueeiai ca aae?anith: 79010, i.
Euea?a, aoe. Iaea?nueea, 69.

C aeena?oaoe??th iiaeia iciaeiieoenue o iaoeia?e a?ae?ioaoe?
Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea
Aaeeoeueeiai (79000, i. Euea?a, aoe. N?/iaeo no??eueoe?a, 6).

Aaoi?aoa?ao ?ic?neaii 10.03. 2000 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Ae 35.600.02

aeioeaio
Aanthe A.Ae.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. Iiooe iiaeo iaeioiene/ieo a?ieia?/ii aeoeaieo
?a/iaei, ye iioaioe?eieo e?ea?nueeeo cania?a, ? iaeiei c aeooaeueieo
caaaeaiue oa?iaoeaaoe/ii? iaoee.

Aeey ae??oaiiy oeeo caaaeaiue iae/ano?oa aeei?enoiaothoueny aeaa oeyoe:
iiaeeo?eaoe?y a?aeiieo a?ieia?/ii aeoeaieo niieoe aai noai?aiiy iiaeo
no?oeoo?, c ianooiiei i?iaaaeaiiyi oe?ieiai oa?iaeieia?/iiai ne?ei?iao.
Cia/iee ?ioa?an aeey iiooeo a?ieia?/ii aeoeaieo niieoe i?aaenoaaeythoue
aaoa?ioeeee?/i? no?oeoo?e, ine?eueee inoaii? aeii?iothoue o no/aniiio
a?naiae? e?ea?nueeeo cania?a. Na?aae ieo cia/ia e?euee?noue ? iio?aeieie
o?acie?aeeio: iai?oeee?ie ??-??? iieie?iue, ?i?oin, o?ii?ie?i, aoacie?i,
eaeeiaai oa ?io?.

A inoaii? ?iee aeaae. C?iaieianueeei A.N., i?io. Eiia?eoeath E.Ae.,
i?io. Ioce/aieii A.I., i?io. Aeaaec?i??nueeith I.A. oa ?ioeie na?aae
iio?aeieo 2-o?iio?acie?aeiio-4 (?iaeai?io) aeyaeaii ?a/iaeie c
i?ioei?e?iaiith, i?ioecaiaeueiith, aiaeueaaoe/iith, iae?ieaioe/iith,
aioea?iiene/iith, o?iiaie?oe/iith, ea?ae?iaaneoey?iith aeoeai?noth,
?ia?a?oi?e aeueaei?aaeoeoace oa aaethoeiaoe?? o?iiaioeeo?a ?
a?eo?ioeeo?a, i?aia?aoe aeey e?eoaaiiy aea?a??, aoa?ineea?ico, ini??aco
oa ?i. I?ioa, neioac a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4 oa
iae?iaaoa?ioeeee?/ieo niieoe ia ?o iniia? aeioaia? ? iaeiaea/aiei.

Ioaea, neioac iiaeo a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4 ?
iae?iaaoa?ioeeee?a ia ?o iniia? i?aaenoaaey? aacia?a/iee ?ioa?an ye c
oai?aoe/ii? oi/ee ci?o, oae ? a ieai? iiooeo iiaeo a?ieia?/ii aeoeaieo
?a/iaei.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie. Aeena?oaoe?eia ?iaioa
aeeiiaia ca?aeii c ieaiii i?iaeaie “Oa?iaoe?y” IIC Oe?a?ie ? ?
o?aaiaioii eiiieaenii? iaoeiai-aeine?aeii? ?iaioe Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai (?
aea?aeaaii? ?a?no?aoe?? 0197U000589, oeo? oaie ?I 10.06.0001.96.).

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoith aeaii? ?iaioe ? neioac iiaeo
iae?iaaoa?ioeeee?/ieo niieoe ia iniia? o?acie?aeiio-4 oa iiooe na?aae
ieo aoaeoeaieo oa iaeioiene/ieo o?c?ieia?/ii aeoeaieo ?a/iaei.

Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaaeaiiy:

— iaea?aeaoe iia? a?oeeee?/i? iaeiiaeainiaai? 2-o?iio?acie?aeiie-4 ia
iniia? 1,5-ae?ai?ii-3-acaiaioaio oa 1,5-ae?ai?ii-3-ienaiaioaio;

— aea/eoe ?aaeoe?? eiiaeainaoe?? caaaeaieo niieoe c aeueaeaa?aeaie
a?iiaoe/iiai ?yaeo;

— neioacoaaoe iae?iaaoa?ioeeee?/i? niieoee oeyoii aoeeethaaiiy
aeeoei?aia?ae?eaeaie aeeea?aiiiaeo eeneio 5’,5”-ae?a?ee?aeaiiio?aeieo
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene
(aoeeo?iea?aiene)-3-acaiaioaio oa
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-ienaiaioaio, ui ai?uothoue a
a?ee?aeaiiaeo noanoeooaioao a?ae?ieneeuei? a?oie;

— iaea?aeaoe iae?iaaoa?ioeeee?/i? niieoee ia iniia? ae?ai?i?a
ae?oaoe/iiai ?yaeo (aoeeaiae?ai?io, aaenaiaoeeaiae?ai?io,
1,5-ae?ai?ii-3-acaiaioaio oa 1,5-ae?ai?ii-3-ienaiaioaio);

— neioacoaaoe iae?iaaoa?ioeeee?/i? iio?aei? o?acie?aeiio-4 ia iniia?
?-ai?iieeneio, a??/e/ieo ie?e oa ae?ai?i?a, ai?iiaoaiieo;

— aea/eoe OO-, ?*- oa II?-niaeo?e neioaciaaieo niieoe;

— aea/eoe aino?o oiene/i?noue oa a?ieia?/io aeoeai?noue neioaciaaieo
niieoe.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

— Aia?oa neioaciaaii iia? a?oeeee?/i? iaeiiaeainiaai?
2-o?iio?acie?aeiie-4 ia iniia? 1,5-ae?ai?ii-3-acaiaioaio oa
1,5-ae?ai?ii-3-ienaiaioaio;

— iaea?aeaii 5’,5”-ae?a?ee?aeaiiio?aei? oa iae?iaaoa?ioeeee?/i?
5’,5”-iiiia?ee?aeaiiio?aei?
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene
(aoeeo?iea?aiene)-3-acaiaioaio oa
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-ienaiaioaio;

— neioaciaaii iia? iae?iaaoa?ioeeee?/i? niieoee oeyoii aoeeethaaiiy
aeeoei?aia?ae?eaeaie aeeea?aiiiaeo eeneio 5’,5”-ae?a?ee?aeaiiio?aeieo
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene(aoeeo?iea?aiene)
-3-acaiaioaio oa
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-ienaiaioaio, ui ai?uothoue a
a?ee?aeaiiaeo noanoeooaioao a?ae?ieneeuei? a?oie;

— aea/aii aca?iiae?th ae?ai?i?a c aea?iieaeoey?iith e?euee?noth
n??eiaoaeaoeth oa neioaciaaii iia? iae?iaaoa?ioeeee?/i? niieoee ia
iniia? aoeeaiae?ai?io, aaenaiaoeeaiae?ai?io, 1,5-ae?ai?ii-3-acaiaioaio
oa 1,5-ae?ai?ii-3-ienaiaioaio. Anoaiiaeaii, ui 3-aee?eaiai?ii?iaeai?ie a
oaeeo oiiaao ia ooai?ththoueny;

— oeyoii ai?iie?co aoeeiaeo anoa??a
5-nae?oeee?aeai-?iaeai?i-3-ea?aiiiaeo eeneio iaea?aeaii cai?uai? ai?aee
eeneio, ui ai?uothoue aeaa o?acie?aeeiia? oeeeee, a eiiaeainaoe??th
caaaeaieo
N,N’-a?n-[?-R-?-(5-nae?oeee?aeai?iaeai?e-3)-aoeaoee]-aeeaiae?ai?i?a c
aeeoei?aia?ae?eaeii aaeei?iiai? eeneioe neioaciaaii ?yae
iae?iaaoa?ioeeee?/ieo niieoe;

— aca?iiae??th 1,5-ae?ai?ii-3-acaiaioaio c aea?iieaeoey?iith e?euee?noth
n??eiaoaeaoeth iaea?aeaii iia? oeeee?/i? aee?eai?iio?ina/iaeie, ia
iniia? yeeo aeeo?iea?aai?iaoiei iaoiaeii iaea?aeaii iiao iaeiiaeainiaaio
a?oeeee?/io niieoeo — N-(aoeeai?iaeai?e-3)-aoeeaio?ina/iaeio;

— oeyoii aca?iiae?? ae?ai?i?a ae?oaoe/iiai ?yaeo c ?cio?ioe?aiaoaie
iaea?aeaii neiao?e/i? a?no?ina/iaeie, i?e eiiaeainaoe?? yeeo c
iiiioei?aoeaoaoiith eeneioith ooai?ththoueny a?oeeee?/i? iaeiiaeainiaai?
inaaaeio?ia?aeaioi?ie;

— iaea?aeai? a?oeeee?/i? iaeiiaeainiaai? inaaaeio?ia?aeaioi?ie
eiiaeainothoueny c aeueaeaa?aeaie a?iiaoe/iiai ?yaeo c ooai?aiiyi
iae?iaaoa?ioeeee?/ieo niieoe;

— eiiaeainaoe??th 3-(?-a?ae?ieneaoee)-?iaeai?io c aeeoei?aia?ae?eaeii
aaeei?iiai? eeneioe iaea?aeaii a?oeeee?/i? iaeiiaeainiaai?
o?acie?aeiie-4, eio?? o ?aaeoe?yo eiiaeainaoe?? c ieniniieoeaie
ooai?ththoue iia? iae?iaaoa?ioeeee?/i? iiiia?ee?aeaiiio?aei?;

— aeey a?oie neioaciaaieo ?a/iaei aea/aia i?ioecaiaeueia, iae?ieaioe/ia
oa oeeoinoaoe/ia ae??. Aeyaeaii ?yae aenieiaeoeaieo ?a/iaei, ye? o
aeayeeo aeiaaeeao ia?aaa?oothoue ae?th no/anieo e?ea?nueeeo i?aia?ao?a
oa oa?aeoa?ecothoueny iecueeith oiene/i?noth.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. I?aaenoaaeaiee o aeai?e
?iaio? aenia?eiaioaeueiee iaoa??ae o aaeoc? neioaco iiaeo a?oeeee?/ieo
iaeiiaeainiaaieo o?acie?aeii?a-4 oa iae?iaaoa?ioeeee?/ieo niieoe,
iaea?aeaieo ia ?o iniia?, ? ooiaeaiaioaeueiei aeine?aeaeaiiyi ? ia?
cia/aiiy aeey oai??? ? i?aeoeee i?aai?/iiai neioaco.

I?iaaaeaia nenoaiaoe/ia aeine?aeaeaiiy o?ce/ieo, o?i?/ieo ? a?ieia?/ieo
aeanoeainoae neioaciaaieo niieoe, aiineoue iia? aeai? uiaei ei?aeyoe??
no?oeoo?e ? o?c?ieia?/ii? ae?? o aea/aiiio ?yae? niieoe, iaiao?aei? aeey
oe?eani?yiiaaiiai neioaco.

Aeyaeai? iia? ia?niaeoeai? oa iaeioiene/i? niieoee, ye? i?iyaeythoue
i?ioecaiaeueio, iae?ieaioe/io oa oeeoinoaoe/io ae?th, caneoaiaothoue
iiaeeaeaiiai oa?iaeieia?/iiai aeine?aeaeaiiy, ye iioaioe?ei? e?ea?nuee?
i?aia?aoe, ui ia? aaeeea i?aeoe/ia cia/aiiy aeey iaaeeoeeie ? oa?iaoe??.

Iaea?aeai? ?acoeueoaoe aeei?enoiaothoueny i?e aeeiiaii? oe?eueiaeo
i?ia?ai o iaoeiaeo aeine?aeaeaiiyo ? iaa/aeueiiio i?ioean? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Ae.Aaeeoeueeiai (aeo
ai?iaaaeaeaiiy a?ae 23 eenoiiaaea 1999 ?.) oa Aea?aeaaiiai oi?aa?neoaoo
“Euea?anueea iie?oaoi?ea” (aeo ai?iaaaeaeaiiy a?ae 22 eenoiiaaea 1999 ?.
).

Iniaenoee aianie caeiaoaa/a. Neioaciaaii 88 iiaeo niieoe o ?yaeo
a?oeeee?/ieo o?acie?aeii?a-4 oa iae?iaaoa?ioeeee?a, aea/aia ?o aoaeiaa,
o?i?/iee neeaae, ?aaeoe?eia caeaoi?noue, aeaye? o?ceei-o?i?/i? oa
a?ieia?/i? aeanoeaino?.

?ic?iaeaii iaoiae neioaco iiaeo iae?iaaoa?ioeeee?/ieo niieoe ia iniia?
ae?ai?i?a ae?oaoe/iiai ?yaeo oa iiaeeo?eiaaii iaoiae neioaco
1,5-ae?ai?ii-3-ienaiaioaio.

Aea/ai? OO-, ?*- oa II?-niaeo?e neioaciaaieo niieoe, ui aeaei ciiao
i?aeoaa?aeeoe ?o o?i?/io no?oeoo?o.

Aeyaeaii ?yae iaeioiene/ieo oa aenieiaeoeaieo niieoe, ye? iathoue
ae?aaeaio i?ioecaiaeueio, iae?ieaioe/io oa oeeoinoaoe/io ae?th. I?e
oeueiio anoaiiaeai? aeaye? aeaiaioe aca?iica’yceo no?oeoo?a-ae?y, ui
aaaeeeai aeey iiaeaeueoeo aeine?aeaeaiue o oeueiio iai?yieo.

Ai?iaaoe?y oa ioae?eaoe?y ?acoeueoao?a aeine?aeaeaiue. Iniiai?
iieiaeaiiy aeena?oaoe?eii? ?iaioe aeiiia?aeaeenue ia XVIII Oe?a?inuee?e
eiioa?aioe?? c i?aai?/ii? o?i?? (Aei?i?iiao?ianuee, 1998), V-io
Iaoe?iiaeueiiio c’?cae? oa?iaoeaao?a Oe?a?ie (Oa?e?a,1999), ??-?e
I?aeia?iaei?e eiioa?aioe?? ani??aio?a (I?oeieueoe, 1999).

Iniiaiee ci?no aeena?oaoe?? a?aeia?aaeaii o 3 noaooyo oa 3 oacao.

No?oeoo?a ? ianya ?iaioe. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 158
noi??ieao ae?oeiaaiiai oaenoo, neeaaea?oueny c anooio, 5 ?icae?e?a
aenia?eiaioaeueieo aeine?aeaeaiue, aeniiae?a, nieneo aeei?enoaieo
e?oa?aoo?ieo aeaea?ae, yeee aeeth/a? 143 iaeiaioaaiiy, oa 2 aeiaeaoe?a.

?iaioa ?ethno?iaaia 21oaaeeoeath (14 noi?.) oa 38 ?enoieaie ( 21noi?.).

Iniiaiee ci?no ?iaioe

1. Neioac a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4 ia iniia?
1,5-ae?ai?ii-3-acaiaioaio, 1,5-ae?ai?ii-3-ienaiaioaio, ?-ai?iieeneio,
aaenaiaoeeai- oa aoeeaiae?ai?io

C iaoith iaea?aeaiiy iiaeo a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4
ia iniia? 1,5-ae?ai?ii-3-acaiaioaio oa 1,5-ae?ai?ii-3-ienaiaioaio
aeei?enoiaoaaee aeeo?iea?aai?iaoiee iaoiae neioaco ?iaeai?i?a:

Noaia 1

O?i?/iee neeaae ? aoaeiaa an?o neioaciaaieo niieoe anoaiiaeaia ca
aeaieie aeaiaioiiai aiae?co ? i?aeoaa?aeaeaia OO-, ?*-,
II?-niaeo?ineii??, ?o ?iaeea?aeoaeuei?noue — iaoiaeaie oiieioa?iai?
o?iiaoia?ao??.

Iayai?noue a?eueii? o?iea?aieneeueii? a?oie a iieaeoe?
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio
i?aeoaa?aeaeaia ooai?aiiyi a?aeiia?aeiiai aoeeiaiai anoa?o (2.2):

Noaia 2

A ?*-niaeo?ao neioaciaaieo a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4
niinoa??aathoueny oa?aeoa?enoe/i? nioae aae?aiiy i?e 2970-2940 ni-1
(?NI2), 1760-1720 ni-1 (?N=I), 1350-1330 ni-1 (?N-N), 1150 ni-1 (?C=S),
1030 ni-1 (?N-I-N) — aeey niieoee 3.1, o aeiaaeeo
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio
i?enooiy nioaa i?e 3490 ni-1 (?II), a eiai aoeeiaee anoa?
oa?aeoa?eco?oueny «ao??iith nioaith» a iaeano? 1210-1155 ni-1.

A OO-niaeo?ao neioaciaaieo niieoe niinoa??aathoueny aeaa iaeneioie
aae?aiiy. Ia?oee iaeneioi i?e ?=250-258 ii coiiaeaiee ?-?* ia?aoiaeii
aeaeo?ii?a a o?iai?aeiiio, a ae?oaee — i?e ?=288-295 ii — a
aeeo?iea?aiiaoiiio o?iiioi?ao.

O II?-niaeo?ao neioaciaaieo niieoe i?enooi? neaiaee an?o i?ioii?a
no?oeoo?, ui i?aeoaa?aeaeo? ?o aoaeiao. Oae, i?ioiie iaoeeaiiaeo a?oi
o?acie?aeeiiaeo oeeee?a
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio
i?iyaeythoueny neiaeaoaie i?e ?=4.259 i./., aee?euei? noanoeooaioe
i?noea, ui c’?aeio? o?acie?aeeiia? e?eueoey — o?eieaoaie i?e ?=4.18-4.23
i./. oa 4.0-4.09 i./., a neaiae i?ioiio o?iea?aieneeueii? a?oie —
neiaeaoii i?e ?=12.35 i./.

O II?-niaeo?? 1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-ienaiaioaio
neaiaee i?ioii?a iaoeeaiiai? a?oie o?acie?aeeiiaiai oeeeeo
i?iyaeythoueny neiaeaoii i?e ?=4.24 i./., a aee?euei? noanoeooaioe
i?noea, ui c’?aeio? ?iaeai?iia? e?eueoey -o?eieaoaie a iaeano? ?=4.0
i./.oa ?=3.6 i./.

Aeey neioaco ?ioeo a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4 ie
i?iaaee ai?iie?c aoeeiaeo anoa??a 5-nae?oeee?aeai?iaeai?e-3-ea?aiiiaeo
eeneio. I?e oeueiio, ye i?aaeei, c aeineoue aenieeie aeoiaeaie
iaea?aeaee cai?uai? ai?aee eeneio, ui ai?uothoue aeaa o?acie?aeeiia?
oeeeee:

Noaia 3

Aeei?enoiaoth/e a?aeiio ?aaeoe?th ia?aeiieo oa aoi?eiieo ae?ai?i?a c
?cio?ioe?aiaoaie, ie iaea?aeaee ?yae neiao?e/ieo a?no?ina/iaei ia iniia?
1,5-ae?ai?ii-3-acaiaioaio, 1,5-ae?ai?ii-3-ienaiaioaio, aoeeai- oa
aaenaiaoeeaiae?ai?i?a:

Noaia 4

Ne?ae cacia/eoe, ui o aeiaaeeo 1,5-ae?ai?ii-3-acaiaioaio ?aaeoe?y
i?io?ea? ? ca aoi?eiiei aoiiii acioo c ooai?aiiyi niieoee, ui ai?uo? o?e
caeeoee o?ina/iaeie:

A?aeiii, ui aca?iiae?y o?ina/iaei c iiiioei?aoeaoaoiith eeneioith
i?ioiaeeoue c cae?eooyi oeeeeo ? i?eaiaeeoue aei ooai?aiiy
inaaaeio?ia?aeaioi?i?a. Neioaciaai? a?no?ina/iaeie, caeiiii??ii,
?aaaothoue c iiiioei?aoeaoaoiith eeneioith. I?e oeueiio aeaeo?io?euei?
aeanoeaino? aaicieueieo e?eaoeue caaaeaieo o?ina/iaei i?aeaeuothoue
?ooeea?noue aoii?a aiaeith a?iiaoe/ii? NH-a?oie, ui iieaaoo?
o?ii-o?ieueio oaooiia??th. Oaeei /eiii, oeeee?caoe?y i?ioiaeeoue c
ooai?aiiyi 2-a?ee?i?iiiio?aeieo a?oeeee?/ieo iaeiiaeainiaaieo
o?acie?aeii?a-4:

Noaia 5

A OO-niaeo?ao aae?aiiy neioaciaaieo niieoe i?iyaeythoueny aea? nioae:
o?iao??ia a iaeano? 200-225 ii oa nioaa i?e 268-278 ii, iia’ycaia c
ia?aiinii aeaeo?ii?a a ?cio?iai?aeiiio o?iiioi??, ui iaeeaaea?oueny ia
eieaeueia caoaeaeaiiy oai?eueieo oeeee?a.

A ?*-niaeo?ao neioaciaaieo niieoe i?iyaeythoueny oa?aeoa?enoe/i? nioae
aae?aiiy i?e 2170 ni-1 (?S-N=N), 1700 ni-1 (?N=I), 1670 ni-1 (?N=N),
eieeaaiiy aaicieueieo e?eaoeue i?e 1450-1420 ni-1 (?N=N).

Aeeo?iea?aai?iaoiei iaoiaeii ia iniia? eieai?io iaea?aeaii
3-(?-a?ae?ien?aoee)-?iaeai?i, aoeeethaaiiy yeiai aeeoei?aia?ae?eaeii
aaeei?iiai? eeneioe i?eaiaeeoue aei ooai?aiiy iiaeo a?oeeee?/ieo
iaeiiaeainiaaieo o?acie?aeii?a-4:

Noaia 6

sse a?aeiii, aca?iiae?y ae?ai?i?a c aea?iieaeoey?iith e?euee?noth
n??eiaoaeaoeth i?eaiaeeoue aei ooai?aiiy oea?ooa?-?iiieo niieoe,
oeeee?caoe??th yeeo iaea?aeothoue oeeee?/i? o?ina/iaeie.

C iaeyaeo ia o?i?/io aoaeiao 1,5-ae?ai?ii-3-acaiaioaio oe?eaai aoei
aeine?aeeoe eiai aca?iiae?th c n??eiaoaeaoeai a aiaeia?/ieo oiiaao.
Ine?eueee aeacaia niieoea ai?uo? o?e aoiie acioo, ui iioaioe?eii
?aaaothoue c n??eiaoaeaoeai, ne?ae aoei i/?eoaaoe ia?aa?ao ?aaeoe?? ca
a?eueo iniiaiei aoi?eiiei acioii. I?ioa, e?euee?nia ia?aaaaeaiiy
ia?aeiieo ai?iia?oi ca?eueoo? eiia??i?noue ooai?aiiy aeeo?iea?aai?iao?a
ca iieiaeaiiyi 1 aai 5.

Aeai? aeaiaioiiai aiae?co oa oiieioa?iai? o?iiaoia?ao?? iieacaee, ui
?aaeoe?y a aeaiiio aeiaaeeo i?ioiaeeoue c ooai?aiii noi?o? ?ciia?ieo
oeeee?/ieo o?ina/iaei (4.13; 4.14). sse iia?/iee i?iaeoeo ?aaeoe?? ie
aeae?eeee c ?aaeoe?eii? noi?o? o?ina/iaeio 4.15, eio?a ca ?aooiie
o?ieueii? oi?ie anooia? a ?aaeoe?th c iiiioei?aoeaoaoiith eeneioith c
ooai?aiiyi a?aeiia?aeiiai inaaaeio?ia?aeaioi?io:

Noaia 7

Aeeo?iea?aai?iaoiei iaoiaeii ia iniia? oeeee?/ii? o?ina/iaeie 4.13 ie
neioacoaaee a?oeeee?/ia iio?aeia, ui ai?uo? e?eueoey oeeee?/ii?
o?ina/iaeie oa ?iaeai?io (3-(2-o?ieni?i?aeacie?aeei?e-3)-aoee?iaeai?i):

Noaia 8

2. Neioac iae?iaaoa?ioeeee?/ieo niieoe

Aiane?aeie aeniei? ?aaeoe?eiino? aoii?a aiaeith iaoeeaiiai? a?oie o
iieiaeaii? 5, o?acie?aeiie-4, a iniaeeai ?iaeai?ie, anooiathoue o
?aaeoe?? eiiaeainaoe?? c ea?aii?eueieie niieoeaie c ooai?aiiyi
5-?e?aeaiiio?aeieo. A?oeeee?/i? iaeiiaeainiaai? o?acie?aeiie-4,
caeiiii??ii, caeaoi? eiiaeainoaaoenue c ieniniieoeaie c ooai?aiiyi iiii-
oa ae??e?aeaiiio?aeieo. I?e oeueiio aeaco?oueny ia iiaeeea?noue
ooai?aiiy ye iae?ioeeee?/ieo, oae ? ianeiao?e/ieo iiii?e?aeaiiio?aeieo
(noaia 9).

Neeaaei?noue aoaeiae oa cia/ia aeaeiaaeai?noue i?noe?a, ui c’?aeiothoue
o?acie?aeeiia? e?eueoey
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-ienaiaioaio,
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio oa
?,?-a?n-(2-a?ee?i?ii-4-ieni-o?acie?aeei-3-?e)aeeai?a coiiaeth? ??ciee
ia?aa?a ?aaeoe?e.

Oae, i?e aea?iieaeoey?iiio ni?aa?aeiioaii?
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio /e
eiai aoeeiaiai anoa?o oa aeueaeaa?ae?a a?iiaoe/iiai ?yaeo, ?aaeoe?y
i?ioiaeeoue c ooai?aiiyi iae?iaaoa?ioeeee?/ieo iiiia?ee?aeaiiio?aeieo.
Neioaciaai? ?a/iaeie ia eiiaeainothoueny c iaaeaeoeiaeie e?eueeinoyie
ieniniieoe, ia ooai?ththoue ae??e?aeaiiio?aeieo, ui ?acii c aeaieie OO-
oa II?-niaeo?ineii?? aeaco? ia ooai?aiiy iae?iaaoa?ioeeee?/ieo no?oeoo?.

I?iaaaeaiiy aiaeia?/ii? ?aaeoe?? i?e cia/iiio iaaeaeoeo ieniniieoe
i?eaiaeeoue aei ooai?aiiy ae?a?ee?aeaiiio?aeieo:

Noaia 9

1,5-A?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-ienaiaioai, iacaeaaeii a?ae
ni?aa?aeiioaiiy eiiiiiaio?a ?aaeoe??, eiiaeaino?oueny c aeueaeaa?aeaie c
ooai?aiiyi ae?a?ee?aeaiiio?aeieo:

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1/2?µ???&??cHw?n??Times New Roman?Y???&?

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?oyOny ???&??cHw?o??`?`??????&?$?cHw?i?
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5????????S?????????????&?$?cHw?i? ???oe5????????S??Noaia 10

I?e i?iaaaeaii? eiiaeainaoe?? a?iiaoe/ieo aeueaeaa?ae?a c
a?n-inaaaeio?ia?aeaioi?iaie i?e ??cieo ni?aa?aeiioaiiyo aeo?aeieo
?a/iaei iaea?aeaii ?yae iae?iaaoa?ioeeee?/ieo iiiia?ee?aeaiiio?aeieo:

Noaia 11

Aiaeia?/ia ?aaeoe?y i?io?ea? i?e aca?iiae?? iiaiiai aaeei?iaoo
3-(?-a?ae?ien?aoee)-?iaeai?io c nae?oeeeiaei aeueaeaa?aeii:

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a?µ???&??cHw?n??Times New Roman?Y???&?$?cHw?i? ????
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?A?•? ???&??cHw?o??`?`??????&?$?cHw?i?
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OO-niaeo?e
1,5-a?n-(2-o?ieni-4-ieni-5-a?ee?aeaio?acie?aeei-3-?e)-3-o?iea?aiene
(aoeeo?iea?aiene)-3-acaiaioai?a oa
1,5-a?n-(2-o?ieni-4-ieni-5-a?ee?aeaio?acie?aeei-3-?e)-3-ienaiaioai?a
oa?aeoa?ecothoueny o?ueiia nioaaie aae?aiiy. Ia?oa nioaa i?e ?=245-260
ii a?aeiia?aea? ia?aiino aeaeo?ii?a o o?iai?aeiiio o?iiioi??, ae?oaa —
i?e ?=272-286 ii — o aeeo?iea?aai?iaoiiio, a o?aoy aeniei?ioaineaia
nioaa i?e ?=360-414 ii coiiaeaia aeaeiaaeaiiyi eaioetha?a eii’thaaoe??
ca ?aooiie a?ee?aeaiiaeo oa?oioaaiue.

A OO-niaeo?ao iae?ioeeee?/ieo iiii?e?aeaiiio?aeieo inoaiiy nioaa
aae?aiiy a?aenooiy.

O II?-niaeo?ao neioaciaaieo niieoe i?enooi? neaiaee an?o i?ioii?a
no?oeoo?e, ui i?aeoaa?aeaeo? ?o aoaeiao.

Iaie aoea i?iaaaeaia ni?iaa neioaco iiiioeeee?/ieo
3-ai?iiaee?e?iaeai?i?a i?e aea?iieaeoey?iiio ni?aa?aeiioaii? ae?ai?i?a
ae?oaoe/iiai ?yaeo, n??eiaoaeaoeth oa iiiioei?aoeaoaoii? eeneioe. I?ioa,
ye iieacaee iao? aeine?aeaeaiiy, ?aaeoe?y a aeaiiio aeiaaeeo i?io?ea? c
ooai?aiiyi iae?iaaoa?ioeeee?/ieo nenoai:

Noaia 13

Cae?eooy iae?ioeeeeo coiiaeaia a?eueo ae?aaeaieie ioeeaio?eueieie
aeanoeainoyie aoiio acioo ia?aeiii? ai?iia?oie a ii??aiyii? c aoiiii
acioo o?iai?aeii? a?oie.

A ?*-niaeo?ao neioaciaaieo niieoe niinoa??aathoueny oa?aeoa?enoe/i?
eieeaaiiy i?e 3420-3244 ni-1 (? NH), 3000-2800 ni-1 (? CH2), 1740-1728
ni-1 (? C=O), 1656-1556 ni-1 (?NH), 1470-1400 ni-1 (?CH a NH2CO),
1170-1140 ni-1 (? C=S).

O II?-niaeo?? 2-o?ieni-7-ieni-1-o?a-3,6-ae?aceoeeeeiieoaio i?enooi?
neaiaee i?ioii?a i?e ?=3.5 i./. (2I, CSNHCH2CH2CO), ?=4.12 i./. (2H,
CSNHCH2CH2CO), ?=4.19 i./. (2H, COCH2S) oa ?=7.93 i./. (2H, 2*NH).
Neaiaee i?ioii?a 2-o?ieni-11-ieni-1-o?a-3,10-ae?aceoeeeeiaeiaeaeaio
i?iyaeythoueny i?e ?=1.2 i./. (10H, CSNHCH2(CH2)5NHCO), ?=3.85 i./.(2H,
CSNHCH2(CH2)5NHCO), ?=4.3 i./. (2H, COCH2S) oa ?=7.31 i./.(2I, 2*NH).

I?e neioacao iae?iaaoa?ioeeee?/ieo niieoe i?ioean oeeee?caoe?? /anoi
i?ioiaeeoue /a?ac noaae?th ooai?aiiy ca’yce?a i?ae aoiiaie aoaeaoeth oa
aaoa?iaoiia. Ooai?aiy oaeeo ca’yce?a cacae/ae a?aeaoaa?oueny a i?ioean?
aoeeethaaiiy aai aee?ethaaiiy aoii?a acioo , n??ee, eenith. Aeey
i?iaaaeaiy aoeeethaaiiy /anoi aeei?enoiaothoue oei?aia?ae?eaee
ea?aiiiaeo eeneio. Aenieee iiceoeaiee ca?yae ia aoii? aoaeaoeth
aeicaiey? aoeeethaaoe iaa?oue ia aeoaea aeoeai? niieoee.

Ie iaea?aeaee ?yae eenaiue-acio-n??eiai?nieo iae?iaaoa?ioeeee?/ieo
niieoe oeyoii aoeeethaaiiy aeeoei?aia?ae?eaeii aaeei?iiai? eeneioe
ae?a?ee?aeaiiio?aeieo iienaieo aeua a?oeeee?/ieo iaeiiaeainiaaieo
o?acie?aeii?a-4, ui ai?uothoue II- a?oie a a?ee?aeaiiaeo eiiiiiaioao.
Aeey caiia?aaiiy ooai?aiiy e?i?eieo /e ?icaaeoaeaieo ie?aiia??a
aeei?enoiaoaaee iaoiae aenieiai ?icaaaeaiiy:

Noaia 14

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?????V????????S? ?E? ??i ???&??cHw?o??`?`??????&?$?cHw?i?
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Aeey aeiaeaoeiai? i/enoee a?ae ie?aiia??a i?iaeoeoe ?aaeoe?? i?iioneaee
/a?ac o?iiaoia?ao?/io eieiieo c A?2I3. ?iaeea?aeoaeuei?noue neioaciaaieo
niieoe i?aeoaa?aeaeaia iaoiaeii oiieioa?iai? o?iiaoia?ao??, o?i?/iee
neeaae ? aoaeiaa anoaiiaeaia ca aeaieie aeaiaioiiai aiae?co oa
niaeo?ineii?/ieo iaoiae?a.

OO-niaeo?e neioaciaaieo niieoe aaaaoi a /iio iaaaaeothoue niaeo?e
aeo?aeieo ae?a?ee?aeaiiio?aeieo ? oa?aeoa?ecothoueny o?ueiia nioaaie
aae?aiiy (i?e 255-260, 288-292 oa 380-384 ii). I?ioa, o?aoy nioaa
aiane?aeie aeaeo?iiiaeoeaioi?iiai aieeao ea?aii?eo aaeei?iiai? eeneioe
a?inio?iiii ci?uaia ia 15-20 ii.

A ?*-niaeo?ao neioaciaaieo iae?iaaoa?ioeeee?/ieo iiaieo aaeei?iao?a
a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4 niinoa??aathoueny
oa?aeoa?enoe/i? nioae aae?aiiy i?e 2900-2800 ni-1 (?NH2), 1740-1700 ni-1
(?N=O), 1456-1400 ni-1 (?N=CH), 1300-1050 ni-1 (?N-O-C), 680-600 ni-1
(?N-S-C) oa aaeaioi? eieeaaiiy aaicieueieo e?eaoeue i?e 1600-1450ni-1
(?N=N).

O II?-niaeo?ao niinoa??aathoueny neaiaee an?o iayaieo o iieaeoeao
i?ioii?a, ui i?aeoaa?aeaeo? ?o no?oeoo?o.

1.1. 3. A?ieia?/ia aeoeai?noue neioaciaaieo niieoe

Neioaciaai? iaie niieoee aoee i?aeaeai? oa?iaeieia?/iiio ne?ei?iao ia
aeyaeaiiy i?ioecaiaeueii?, iae?ieaioe/ii? oa oeeoinoaoe/ii? aeoeaiino?.

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui neioaciaai? niieoee
a?aeiinyoueny aei iaei- aai iii??iioiene/ieo ?a/iaei.

I?ioecaiaeueia oa iae?ieaioe/ia aeoeaiino? aea/aeenue ia aac?
Oeaio?aeueii? iaoeiai-aeine?aeii? eaai?aoi??? Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai, a oeeoinoaoe/ia
aeoeai?noue — ia eaoaae?? iaaee/ii? a?ieia?? Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai.

Aeey aeine?aeaeaiiy i?ioecaiaeueii? ae?? neioaciaaieo niieoe
aeei?enoiaoaaeanue oi?iae?iiaa iiaeaeue caiaeueiiai iaa?yeo eaiee uo?a.
?acoeueoaoe aeine?aeaeaiue aeacothoue, ui aeaye? c aeine?aeaeoaaieo
?a/iaei i?iyaeythoue aenieo i?ioecaiaeueio aeoeai?noue. Oae, ii??aiyiiy
?o i?ioecaiaeueii? ae?? c aieueoa?aiii o aeeiai?oe? iieacaei, ui aaea
/a?ac 3 aiae. i?ney aaaaeaiiy niieoea 2.18 ia 29%, a /a?ac 5 aiae. ia
19% ia?aaeuo? eiai aeoeai?noue. Niieoee 3.1, 3.2, 4.27 oa 4.36 /a?ac 3
aiae. aoee aoaeoeai?oeie a?ae aieueoa?aio, i?ioa aaea ia 5-oo aiaeeio
iinooiaeeny eiio ia 6-12%. Iaiao?aeii caoaaaeeoe,ui /?oei? ei?aeyoe??
i?ae i?ioecaiaeueiith aeoeai?noth oa aoaeiaith aeine?aeaeoaaieo niieoe
aeyaeoe ia aaeaeiny.

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui aeaye? c neioaciaaieo niieoe
i?iyaeythoue iae?ieaioe/io aeoeai?noue. Niieoea 4.36
(2-o?ieni-7-ieni-1-o?a-3,6-ae?aceoeeeeiieoai) i?iaeiaaeo? aaenaiaeiaee
nii ia ??ai? ai?iaceio oa caneoaiao? ia iiaeaeueoa aea/aiiy.

Anoaiiaeaii, ui neioaciaai?
?,?-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)aeeaie oa ?o
5-a?ee?aeaiiio?aei? o eiioeaio?aoe?? 210-5 iieue/e i?iyaeythoue ae?acio
oeeoinoaoe/io ae?th ia ii?iaeuei? oa iooeeii? ee?oeie. Oae?
eiioeaio?aoe?? ia ? aenieeie noiniaii a?ieia?/ii? ae?? oa?iaeieia?/ieo
i?aia?ao?a. ?ia?a?oi?e ??ciiiai?oieo a?io?i?/ieo ?aaeoe?e, ?iiiiai
o?ainii?oo aeei?enoiaothoue o eiioeaio?aoe?yo oaeiai ae ii?yaeeo.

Aieea i?aia?ao?a ia i?ie?oa?aoe?th ee?oei aea/aee ca ?ioaineai?noth
neioaco AeIE o ee?oeiao e?i?? A-549 aaeaiiea?oeeiiie eaaaiue ethaeeie oa
ea?oeeiiiieo ee?oeiao e?i?? NNL-64 c ai?oae?th eaaaiue ii?ee.
?ioaineai?noue neioaco AeIE aecia/aee ca aaee/eiith aeeth/aiiy
?I-oei?aeeio a AeIE.

Aianaiiy aeine?aeaeoaaieo niieoe (1*10-5 iieue/e ) o eoeueoo?aeueia
na?aaeiaeua, o yeiio ia?aaoaaee ee?oeie e?i?? A-549 aaeaiiea?oeeiiie
eaaaiue ethaeeie, ni?e/eiyei ciaioaiiy ?ioaineaiino? aeeth/aiiy
?I-oei?aeeio o AeIE. Oae, niieoee 2.1, 2.8, 2.19 oa 2.22 i?eai?/oaaee
neioac AeIE o 1.23, 1.18, 1.27 oa 1.51 ?ace, a?aeiia?aeii. Niieoee 3.1,
3.3, 3.6, 2.7, 2.26, 2.27 oa 2.16 aoee a?eueo aoaeoeaieie oa ?ia?aoaaee
neioac AeIE o 2.28, 1.98, 2.90, 2.03, 2.07, 3.69 oa 2.02 ?ace,
a?aeiia?aeii.

I?e ii??aiyii? oeeoinoaoe/ii? eiioaeoii? ae?? iaeaeoeai?oeo c
neioaciaaieo iaie niieoe (niie. 2.27 oa 3.6) c a?aeiieie i?ioeiooeeiieie
i?aia?aoaie, oaeeie ye Iaee?oaenae (Ebewe Arzeminittel Ges. m.b.H.,
Aano??y), Aiaeienai (ASOA Medica, I?ia//eia), Oeenieaoei (Ebewe
Arzeminittel Ges. m.b.H., Aano??y), Eiionoei (Rhone-Poulenc Rorer,
O?aioe?y- NOA) aeine?aee i?iaiaeeeenue o aaniethoii iaeiaeiaeo oiiaao oa
c iaeiaeiaith eiioeaio?aoe??th i?aia?ao?a (210-5 iieue/e).

Anoaiiaeaii, ui
1,5-a?n-(2-o?ieni-4-ieni-5-aai?e?aeaio?acie?aeei-3-?e)-3-ienaiaioai
(niie. 3.6), i?eai?/oth/e neioac AeIE o 11.8 ?ac?a, ca oeeoinoaoe/iith
eiioaeoiith aeoeai?noth ia iinooia?oueny Iaee?oaenaeo.
1,5-A?n-(2-o?ieni-4-ieni-5-aai?e?aeaio?acie?aeei-3-?e)-3-aoeeo?iea?aiene
-3-acaiaioai (niie. 2.27) oaeiae aeyaey? aenieo eiioaeoio oeeoinoaoe/io
aeoeai?noue, ?ia?aoth/e neioac AeIE o 7 ?ac?a, aeaui iinooiath/enue
aeoeai?noth niieooe? 3.6 ? ciaoiaeeoueny ia??ai? c Eiionoeiii.

Ia iniia? iaaaaeaieo ?acoeueoao?a iiaeia i?eeoe aei aeniiaeo, ui ia
oeeoinoaoe/io aeoeai?noue aieeaa? ye i?e?iaea i?noea, ui c’?aeio?
?iaeai?iia? e?eueoey, oae ? a?ee?aeaiiaee caeeoie. Aaaaeaiiy
a?ee?aeaiiaeo caeeoe?a o iieiaeaiiy 5, ye i?aaeei, i?aeaeuo?
oeeoinoaoe/io ae?th neioaciaaieo o?acie?aeii?a-4. Iniaeeai neeueii oea
iii?oii o aeiaaeeo 5-aai?e?aeaiiio?aeieo (niieoee 3.6 oa 2.27).

I?iaaaeai? a?ieia?/i? aeine?aeaeaiiy iieacaee, ui aeaeio?? c aia?oa
neioaciaaieo iaie ?a/iaei, ye? oa?aeoa?ecothoueny iaeith oiene/i?noth
oa aenieith oa?iaeieia?/iith aeoeai?noth, ? iioaioe?eieie e?ea?nueeeie
caniaaie.

2. Caaaeuei? Aeniiaee

1. Aca?iiae?y ae?oaoe/ieo ae?ai?i?a c n??eiaoaeaoeai i?eaiaeeoue aei
ooai?aiiy aeeo?iea?aai?iao?a, aoaeiaa yeeo caeaaeeoue a?ae
ni?aa?aeiioaiiy eiiiiiaio?a.

I?e aea?iieaeoey?iiio ni?aa?aeiioaii? ooai?ththoueny aeeo?iea?aai?iia?
eeneioe o aeaeyae? oea?ooa?-?iiieo niieoe, a i?e ni?aa?aeiioaii? 1:2 o
eoaeiiio na?aaeiaeu? – a?n-aeeo?iea?aai?iaoe. Eiiaeainaoe?y inoaii?o c
iiiioei?aoeaoaoiith eeneioith i?eaiaeeoue aei ooai?aiiy
?,?-a?n?iaeai?e-3-aeeai?a, a a ia?oiio aeiaaeeo ooai?ththoueny
iae?iaaoa?ioeeee?/i? niieoee.

2. Ai?iie?c aoeeiaeo anoa??a 5-a?ee?aeai?iaeai?i-3-ea?aiiiaeo eeneio
ae?oaoe/ieie ae?ai?iaie i?eaiaeeoue aei ooai?aiiy a?oeeee?/ieo
iaeiiaeainiaaieo a?n?iaeai?i?a, ui a?aeiinyoueny aei cai?uaieo ai?ae?a
eeneio.

3. I?e aca?iiae?? ae?oaoe/ieo ae?ai?i?a c ?cio?ioe?aiaoaie
ooai?ththoueny neiao?e/i? a?no?ina/iaeie, eiiaeainaoe?y yeeo c
iiiioei?aoeaoaoiith eeneioith i?eaiaeeoue aei ooai?aiiy a?oeeee?/ieo
o?acie?aeii?a-4 (inaaaeio?ia?aeaioi?i?a).

4. Aca?iiae?y eieai?io c n??eiaoaeaoeai oa ianooiia eiiaeainaoe?y
iaea?aeaiiai aeeo?iea?aai?iaoo c iiiioei?aoeaoaoiith eeneioith
i?ioiaeeoue c ooai?aiiyi 3-(?-a?ae?ieneaoee)-?iaeai?io, i?e aoeeethaaii?
yeiai ooai?ththoueny a?oeeee?/i? iaeiiaeainiaai? o?acie?aeiie-4, ui
a?aeiinyoueny aei eeano anoa??a.

5. I?e aca?iiae?? 1,5-ae?ai?ii-3-acaiaioaio c aea?iieaeoey?iith
e?euee?noth n??eiaoaeaoeth ooai?th?oueny noi?o oeeee?/ieo o?ina/iaei, ui
ai?uothoue ia?aeiio aai aoi?eiio ai?iio a?oie. Ia iniia? ia?oi?
aeeo?iea?aai?iaoiei iaoiaeii iaea?aeaii iiao a?oeeee?/io iaeiiaeainiaaio
niieoeo — N-(aoeeai?iaeai?e-3)-aoeeaio?ina/iaeio.

6. I?e eiiaeainaoe?? iaea?aeaieo a?oeeee?/ieo iaeiiaeainiaaieo
o?acie?aeii?a-4 c a?iiaoe/ieie aeueaeaa?aeaie ooai?ththoueny
iae?iaaoa?ioeeee?/i? iiii?e?aeaiiio?aei? oa ae??e?aeaiiio?aei?. Iai?yiie
?aaeoe?? caeaaeeoue a?ae ni?aa?aeiioaiiy eiiiiiaio?a oa i?e?iaee
“aio/eiai i?noea”, aeaeiaaeaiiy yeiai ni?ey? ooai?aiith
iae?iaaoa?ioeeee?/ieo niieoe.

7. Aoeeethaaiiy iaea?aeaieo aeea?ae?ien?a?ee?aeaiiio?aeieo
aaeiaaiaia?ae?e-aeaie aeeea?aiiiaeo eeneio a oiiaao iaoiaeo aenieiai
?icaaaeaiiy i?eaiaeeoue aei iaea?aeaiiy iae?iaaoa?ioeeee?/ieo niieoe, ui
ai?uothoue aeaa o?acie?aeeiia? e?eueoey.

8. Ia iniia? a?ieia?/ieo aei?iaoaaiue o aeine?aeaeoaaieo ?yaeao niieoe
anoaiiaeaii, ui ?,?-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-R-aeeaie oa
?o iio?aei? i?iyaeythoue i?ioecaiaeueio, iae?ieaioe/io oa oeeoinoaoe/io
aeoeai?noue.

I?e/iio anoaiiaeaii, ui ia oeeoinoaoe/io aeoeai?noue aieeaa? ye i?e?iaea
“i?noea”, oae ? cai?niee?a o iieiaeaii? 5. Oae,
1,5-a?n(2-o?ieni-4-ieni-5-aai?e?aeai o?acie?aeei-3-?e)-3-ienaiaioai
(niieoea 3.6) ca oeeoinoaoe/iith eiioaeoiith aeoeai?noth ia
iinooia?oueny Iaee?oaenaeo, a
1,5-a?n-(2-o?ieni-4-ieni-5-aai?e?aeaio?acie?aeei-3-?e)-3-aoeeo?iea?aiene
-3-acaiaioai (niieoea 2.27) ciaoiaeeoueny ia??ai? c Eiionoeiii.

Aaaaeaiiy a?ee?aeaiiaeo caeeoe?a o iieiaeaiiy 5, ye i?aaeei, i?aeaeuo?
oeeoinoaoe/io ae?th neioaciaaieo a?oeeee?/ieo iaeiiaeainiaaieo
o?acie?aeii?a-4. Iniaeeai neeueii oea iii?oii o aeiaaeeo 5-aai?e?aeai
iio?aeieo.

9. Aea/aii OO-, ?*-, II?-niaeo?e oa o?ceei-o?i?/i? aeanoeaino?
iaea?aeaieo a?oeeee?/ieo oa iae?iaaoa?ioeeee?/ieo niieoe.

Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe??

3. 1. Oia?aaea ss.A., Ioce/aiei A.I., C?iaieianueeee A.N. Neioac
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio oa
eiai 5-?e?aeaiiio?aeieo // Oa?iaoe. aeo?i. -1999.- ?3. — N.47-51.

2. Oia?aaea ss.A., Ioce/aiei A.I., C?iaieianueeee A.N. Neioac
iae?iaaoa?ioeeee?/ieo niieoe ia iniia?
1,5-a?n-(2-o?ieni-4-ienio?acie?aeei-3-?e)-3-o?iea?aiene-3-acaiaioaio //
Oa?iaoe. aeo?i. — 1999.- ?4. — N.44-46.

3. Oeeoinoaoe/ia ae?y aeayeeo a?oeeee?/ieo iaeiiaeainiaaieo
o?acie?aeii?a-4 ia ii?iaeuei? oa iooeeii? ee?oeie/ Ioce/aiei
A.I.,C?iaieianueeee A.N., Ai?iaaoeue C. Ae., Oia?aaea ss.A.// E?ee. –
1999. — ?5-6. — N.60-64.

4. Oia?aaea ss.A., Ioce/aiei A.I., C?iaieianueeee A.N. Neioac
a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4 ia iniia?
1,5-ae?ai?ii-3-acaiaioaio // Oac. aeii. XVIII Oe?a?inueei? eiioa?aioe??
c i?aai?/ii? o?i??, 6-8 aeiaoiy 1998?. — Aei?i?iiao?ianuee, 1998. —
N.155.

5. Oia?aaea ss.A., Ioce/aiei A.I., C?iaieianueeee A.N. Neioac
iae?iaaoa?ioeeee?/ieo niieoe ia iniia? ae?ai?i?a // Oac. aeii. V-ai
Iaoe?iiaeueiiai c’?caeo oa?iaoeaao?a Oe?a?ie, 6-9 aa?aniy 1999?. —
Oa?e?a, 1999. – N.467.

6. Yaryna Shpargala. New bicyclic non-condensited thiazolidones-4 and
their cytostatic activity // Thesises of reports IInd International
Conference of PhD Students. — Miskolc, 1999. – N. 144.

Oia?aaea ss.A. «Neioac, ia?aoai?aiiy oa a?ieia?/ia aeoeai?noue
iae?iaaoa?ioeeee?/ieo niieoe ia iniia? o?acie?aeiio-4.» — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa oa?iaoeaaoe/ieo
iaoe ca niaoe?aeuei?noth 15.00.02 — oa?iaoeaaoe/ia o?i?y oa
oa?iaeiaiic?y. Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.
Aeaieea Aaeeoeueeiai, Euea?a, 1999.

Neioac iiaeo iaeioiene/ieo a?ieia?/ii aeoeaieo niieoe ? iaeiei c
aeooaeueieo caaaeaiue oa?iaoeaaoe/ii? iaoee. Iaoith aeaii? ?iaioe ?
neioac iiaeo iae?iaaoa?ioeeee?/ieo niieoe ia iniia? o?acie?aeiio-4 oa
aea/aiiy ?o a?ieia?/ii? aeoeaiino?.

Ia iniia? ae?ai?i?a ae?oaoe/iiai ?yaeo, ?-ai?iieeneio, eieai?io
neioaciaaii ?yae a?oeeee?/ieo iaeiiaeainiaaieo o?acie?aeii?a-4. ?o
eiiaeainaoe??th c aeueaeaa?aeaie a?iiaoe/iiai ?yaeo iaea?aeaii aee- oa
iae?ioeeee?/i? iiii?e?aeaiiio?aei?. Anoaiiaeaii, ui iai?yiie ?aaeoe??
caeaaeeoue a?ae ni?aa?aeiioaiiy eiiiiiaio?a oa i?e?iaee “aio/eiai
i?noea”.

Oeyoii aoeeethaaiiy aeea?ae?ien?ae?a?ee?aeaiiio?aeieo a?oeeee?/ieo
iaeiiaeainiaaieo o?acie?aeii?a-4 aaeiaaiaia?ae?eaeaie aeeea?aiiiaeo
eeneio a oiiaao iaoiaeo aenieiai ?icaaaeaiiy iaea?aeaii iia?
iae?iaaoa?ioeeee?/i? niieoee.

?ic?iaeaii iaoiae neioaco iiaeo iae?iaaoa?ioeeee?/ieo niieoe ia iniia?
ae?oaoe/ieo ae?ai?i?a.

No?oeoo?o neioaciaaieo niieoe i?aeoaa?aeaeaii aeaieie aeaiaioiiai
aiae?co, OO-, ?*-, II?-niaeo?ineii??, ?o ?iaeea?aeoaeuei?noue —
oiieioa?iaith o?iiaoia?ao??th.

Aeyaeaii ?yae iecueeioiene/ieo niieoe, ye? i?iyaeythoue i?ioecaiaeueio,
iae?ieaioe/io, oeeoinoaoe/io aeoeai?noue oa anoaiiaeaii aeaye? aeaiaioe
aca?iica’yceo “no?oeoo?a-ae?y”.

Eeth/ia? neiaa: neioac, a?no?acie?aeiie-4, iae?iaaoa?ioeeee?/i? niieoee,
niaeo?aeuei? oa?aeoa?enoeee, oa?iaeieia?/i? aeine?aeaeaiiy.

Oia?aaea ss.A. «Neioac, i?aa?auaiey e aeieiae/aneay aeoeaiinoue
iae?iaaoa?ioeeeee/aneeo niaaeeiaiee ia iniiaaiee oeacieeaeiia-4.» —
?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa oa?iaoeaaoe/aneeo
iaoe ii niaoeeaeueiinoe 15.00.02 — oa?iaoeaaoe/aneay oeiey e
oa?iaeiaiicey. Eueaianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao
ei. Aeaieea Aaeeoeeiai.

Oeaeueth aeaiiie ?iaiou yaeyaony neioac iiauo iae?iaaoa?ioeeeee/aneeo
niaaeeiaiee ia iniiaaiee oeacieeaeiiia-4 e enneaaeiaaiea eo
aeieiae/aneie aeoeaiinoe.

Acaeiiaeaenoaea aeeoaoe/aneeo aeeaieiia (1,5-aeeaieii-3-aca (iena)
-iaioaia, aanaiaoeeai (yoeeai) -aeeaieia) n na?ioaea?iaeii i?ioiaeeo n
ia?aciaaieai aeeoeiea?aaieiaoia, no?iaiea eioi?uo caaeneo io niioiioaiey
eiiiiiaioia ?aaeoeee. I?e yeaeiieaeoey?iii niioiioaiee ia?acothony
aeeoeiea?aaieiiaua eeneiou a aeaea oeaeooa?-eiiiuo niaaeeiaiee. Eo
acaeiiaeaenoaea n iiiioei?oenoniie eeneioie e eiioeaio?e?iaaiiie
oei?eaeiie eeneioie i?ioiaeeo n cae?uoeai oeeeea e aaaeao e ia?aciaaieth
iiauo iae?iaaoa?ioeeeee/aneeo no?oeoo?.

I?e niioiioaiee aeeaieiia (1,5-aeeaieii-3-aca(iena)iaioaia) e
na?ioaea?iaea 1:2 iieo/aii iiaua aeoeeeee/aneea iaeiiaeaine?iaaiiua
oeacieeaeiiu-4.

?yae iiauo aenoeacieeaeiiia-4 neioace?iaaii iooai aieiieeca yoeeiauo
ynoa?ia 5-naeeoeeeeaeai?iaeaiei-3-ea?aiiiauo eeneio aeeaieiai
aeeoaoe/aneiai ?yaea (yoeeai- e aaenaiaoeeaiaeeaieiia).

Acaeiiaeaenoaeai aeeoaoe/aneeo aeeaieiia (yoeeai-, aaenaiaoeeaiaeeaieia,
1,5-aeeaieii-3-aca(iena)iaioaia) n oaieeecioeioeeaiaoii iieo/aii
neiiao?e/iua aenoeiii/aaeiu, eioi?ua eiiaeaine?othony n iiiioei?oenoniie
eeneioie n ia?aciaaieai iiauo aeoeeeee/aneeo iaeiiaeaine?iaaiiuo
2-a?eeeieiioeacieeaeiiia-4.

Eiiaeainaoeey neioace?iaaiiuo aenoeacieeaeiiia-4 n a?iiaoe/aneeie
aeueaeaaeaeaie aaaeao e ia?aciaaieth aeea?eeeaeai- e
iae?iaaoa?ioeeeee/aneeo iiiia?eeeaeaii?iecaiaeiuo. Onoaiiaeaii, /oi
iai?aaeaiea ?aaeoeee caaeneo io niioiioaiey eiiiiiaioia e i?e?iaeu
«aeaeiai iinoeea».

Aoeeee?iaaieai neioace?iaaiiuo aeeaeae?ieneaeea?eeeaeaii?iecaiaeiuo
aeoeeeee/aneeo iaeiiaeaine?iaaiiuo oeacieeaeiiia-4 aaeiaaiaiaeae?eaeaie
aeeea?aiiiauo eeneio iieo/aii iiaua iae?iaaoa?ioeeeee/aneea niaaeeiaiey,
niaea?aeaueo aeaa oeacieeaeeiiaua eieueoea e ioiinyueony e eeanno
ynoa?ia. Aeey i?aaeioa?auaiey ia?aciaaiey i?iaeoeoia ieeaiia?iiai
oa?aeoa?a ?aaeoeeth i?iaiaeeee a oneiaeyo iaoiaea aunieiai ?acaaaeaiey.
Aeey aeiiieieoaeueiie i/enoee neioace?iaaiiuo iae?iaaoa?ioeeeee/aneeo
niaaeeiaiee eniieueciaaee eieiii/ioth o?iiaoia?aoeth.

No?oeoo?u anao neioace?iaaiiuo niaaeeiaiee iiaeoaa?aeaeaiu aeaiiuie
yeaiaioiiai aiaeeca, OO-, EE-, II?-niaeo?aie, eo eiaeeaeaeoaeueiinoue —
iaoiaeii o?iiaoia?aoee a oiieii neia ni?aaioa.

Neioace?iaaiiua niaaeeiaiey iiaeeaaeaee oa?iaeieiae/aneiio ne?eieiao
aeey onoaiiaeaiey i?ioeaiainiaeeoaeueiie, iae?ieaioe/aneie e
oeeoinoaoe/aneie aeoeaiinoe.

I?iaaaeaiiiua enneaaeiaaiey iieacaee, /oi neioace?iaaiiua niaaeeiaiey
i?eiaaeeaaeao e iaei- eee ioiineoaeueiioiene/aneei aauanoaai.

Iaia?oaeaii ?yae aauanoa, eioi?ua i?iyaeytho aunieoth
i?ioeaiainiaeeoaeueio aeoeaiinoue. Oae, n?aaiaiea eo
i?ioeaiainiaeeoaeueiiai aeaenoaey n aieueoa?aiii a aeeiaieea iieacaei,
/oi oaea ia 3-ee /an iinea aaaaeaiey aauanoai 2.18 ia 29%, a ia 5 /an ia
19% i?aauoaao aai aeoeaiinoue.

I?iaaaeaiiua enneaaeiaaiey iieacaee, /oi iaeioi?ua ec neioace?iaaiiuo
niaaeeiaiee i?iyaeytho iae?ieaioe/aneoth aeoeaiinoue.

Onoaiiaeaii, /oi neioace?iaaiiua
?,?-aen-(2-oeieni-4-ienioeacieeaeei-3-ee)aeeaiu e eo
5-a?eeeaeaii?iecaiaeiua a eiioeaio?aoeee 210-5 iieue/e i?iyaeytho
oeeoinoaoe/aneia aeaenoaea ia ii?iaeueiua e iiooieaaua eeaoee. Aeeyiea
i?aia?aoia ia i?ieeoa?aoeeth eeaoie eco/aee ca eioaineaiinoueth neioaca
AeIE a eeaoeao eeiee A-549 aaeaiiea?oeeiiiu eaaeeo /aeiaaea e
ea?oeeiiiiuo eeaoie eeiee NNL-64 ec yieoaeey eaaeeo ii?ee.

Oae 1,5-aen-(2-oeieni-4-ieni-5-aaieeeaeaioeacieeaeei-3-ee)-3-ienaiai-oai
(niaae. 3.6), oaiaoay neioac AeIE a 11.8 ?ac, ca oeeoinoaoe/aneie
eiioaeoiie aeoeaiinoueth ia onooiaao Iaeeeoaenaeo.
1,5-Aen-(2-oeieni-4-ieni-5-aaieeeaeaioeacieeaeei-3-ee)-3-yoeeoeiea?aiene
-3-acaiaioai (niaae. 2.27) oaeaea i?iyaeyao aunieoth eiioaeoioth
oeeoinoaoe/aneoth aeoeaiinoue, eiaeae?oao neioac AeIE a 7 ?ac, iaiiiai
onooiay aeoeaiinoueth niaaeeiaieth 3.6 e iaoiaeeony ia?iaia n
Eiionoeiii.

Eeth/aaua neiaa: neioac, aenoeacieeaeiiu-4, iae?iaaoa?ioeeeee/aneea
niaaeeiaiey, niaeo?aeueiua oa?aeoa?enoeee, oa?iaeieiae/aneea
enneaaeiaaiey.

Shparhala Ya. B. «Synthesis, conversions and biological activity of
macroheterocyclic compounds on the base of thiazolidones-4.» —
Manuscript.

Thesis is compiled to obtain scientific degree of candidate of
pharmaceutical sciences in specyality — 15.00.02 — pharmaceutical
chemistry and pharmacognosy. — Danylo Halytsky Lviv State Medical
University, 2000.

Actual aim of Pharmacy is a search for the new low-toxic substances with
biological activity. Synthesis of the new macroheterocyclic compounds
with the thiazolidone-4 base and research of their biological activity
are the aims of this thesis.

The variety of new noncondensed bisthiazolidones-4 is synthesized on the
base of the primary alifatic diamines, ?-aminoacids, colamine.
Condensing them with the aromatic aldehydes results in formation of
diylidene- and macrocyclic monoylidenederivatives.

Acylation of synthesized bicyclic noncondensed
dihydroxydiarylidenederivatives by halohenanhydrides of dicarboxylic
acids leads to the formation of the new macroheterocyclic compounds
which contain two thiazolidone cycles. The reaction is carry out in the
conditions of high dilution method.

New method was designed to synthesize new macroheterocyclic compounds on
the base of alifatic diamines.

Structure of all synthesized compounds is confirmed by element analysis
data, UV, IR, 1H-NMR- spectrums. Their distinction is confirmed by
thin-layer chromatography.

Number of compounds which possess distinct anti-inflammatory,
neiroleptic, cytostatic activity and are charecterized by low toxicity
were discovered by biological research of synthesized compounds.

Key words: synthesis, bisthiazolidone-4, macroheterocyclic compound,
spectral feature, pharmacological studies.

I?aeienaii aei ae?oeo 29.02.2000?. Oi?iao 60o84/16.

Iai?? ae?oea?nueeee. Ae?oe Riso. Ia’?i 1 ae?oe. a?e. Cai. ?43. Iaeeaae
100.

Iaae?eiaaii o aeaeaaieoeoa? aea?aeaaiiai oi?aa?neoaoo “Euea?anueea
iie?oaoi?ea”

79013, i.Euea?a, aoe. No. Aaiaea?e, 12

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