1

I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEA IAAeE*IA NOIIAOIEIA?*IA AEAAeAI?ss

Ia i?aaao ?oeiieno

IACA?ssI ?icaia Noaiai?aia

OAeE 616. 314 — 08 — 039. 71 — 083

?ic?iaea oa iaa?oiooaaiiy canoinoaaiiy a?o/eciyiiai ooi?ai?uoth/iai
aa?iaoeea

“Aeaioaeaen-11O”

(eaai?aoi?ii-ee?i?/ia aeine?aeaeaiiy)

14.01.22 — Noiiaoieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Iieoaaa — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie (?aeoi? — aeaaeai?e A.ss. Oeeaaiaiei) ia eaoaae?? oa?aiaaoe/ii?
noiiaoieia?? (caa?aeoaa/ea eaoaae?ith — i?ioani? Eaoo?iaa Aaeeia
Oaaei??aia).

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, i?ioani? Eaoo?iaa Aaeeia
Oaaei??aia, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
caa?aeoaa/ea eaoaae?e oa?aiaaoe/ii? noiiaoieia??.

Io?oe?ei? iiiiaioe:

1. Aeieoi? iaaee/ieo iaoe, i?ioani? Oiiaiei Ea?ena Ieaenaiae??aia,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. aeaae. I.I. Aiaiiieueoey,
caa?aeoaa/ea eaoaae?e aeeoy/i? oa?aiaaoe/ii? noiiaoieia?? c eo?nii
i?io?eaeoeee noiiaoieia?/ieo caoai?thaaiue.

2. Aeieoi? iaaee/ieo iaoe, i?ioani? Aee/ei ?aaai Ieeeoi?iae/,
Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y, caa?aeoaa/ eaoaae?e
aeeoy/i? noiiaoieia?? ? noiiaoieia?? ?ioa?i?a.

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?
ina?oe ?i. I.E. Ooieea IIC Oe?a?ie, eaoaae?a oa?aiaaoe/ii? noiiaoieia??
c eo?nii aeeoy/i? noiiaoieia??.

Caoeno a?aeaoaeaoueny “ 19 ” aeiaoiy 1999 ?ieo i 13-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae41.601.01 i?e Oe?a?inuee?e
iaaee/i?e noiiaoieia?/i?e aeaaeai?? ca aae?anith: 314023, i. Iieoaaa,
aoe. Oaa/aiei, 23.

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Oe?a?inueei?
iaaee/ii? noiiaoieia?/ii? aeaaeai?? ca aae?anith: 314023, i. Iieoaaa,
aoe. Oaa/aiei, 23.

Aaoi?aoa?ao ?ic?neaiee “ 26 ” eeiiy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe, aeioeaio I.A. Aieiaei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia o?no?iiai ea???no iino?eieo coa?a o ae?oae
oa eiai iiia?aaeaeaiiy i?iaeiaaeo? caeeoaoeny iaeiei c iaea?eueo
aeooaeueieo oa iiai?noth ia ae??oaieo ieoaiue no/anii? noiiaoieia??. Oea
iaoiiaeaii cia/iith ?ioaineai?noth oa aenieith ?iciianthaeaeai?noth
oeueiai caoai?thaaiiy [Aeaoue?aa A.A., 1990; Eocuei?ia A.I. ? ni?aaao.,
1992; Aeiia?aaeiaa O.O., 1988; Aeueaea?ooaaa C.A., 1989; Riethe P.,
1994; Eenaeueieeiaa E.I., 1993; Noanaieiaa I.A., 1996; Aaeue/thiaia
?.A., Ieeoeyae/aia A.E., 1985; Ai?ianueeee A.A., Eaiioue?a A.E., 1991;
Winter G.B., 1990].

On? caniae caaaeueii? oa i?noeaai? i?io?eaeoeee ea???no iino?eieo coa?a
o ae?oae, ye? iathoue o nai?io ?icii?yaeaeaii? e?ea??-noiiaoieiae,
iaea?eueo aoaeoeai? i?e canoinoaaii? ?o ia aeaaeaiueeeo iiaa?oiyo coa?a
[Aoeaiiaa A.E., 1992; Pinto J.L., 1993; Seppa L., Pollanen L., 1987;
Holm G.B., Holst K., Mejare J., 1984].

Oiio a inoaii? ?iee o na?oia?e i?aeoeoe? oe?iei canoiniao?oueny iiaee
i?eioeei i?io?eaeoeee ea???no o?no? — ieanoeea aiae? [Cohen L.A.,1993;
Anderson M.H.,1993; Ford J.F.,1993; Swilt E.I., 1988; Simonsen R.J.,
1989; Cooney P.V., 1994; Joseph V.P., 1992]. A a?naiae? oe?a?inueei?
noiiaoieia?? ooi?ai?uoth/? aa?iaoeee a?o/eciyiiai ae?iaieoeoaa
a?aenooi?. I?e oeueiio a?eueo?noue c caei?aeiiieo aa?iaoee?a, ye?
aeei?enoiaothoueny a?o/eciyieie e?ea?yie — oea aa?iaoeee o?eueee
?cieyoi?iiai oeio, ye? ia iathoue o nai?io neeaae? i?ioeea??icieo
?a/iaei. Ae?iaieoeoai caei?aeiiieo iaoa??ae?a aeey caia/aooaaiiy o?no?
eaea o iai?yieo noai?aiiy iaiaiiaiaieo eiiiiceoe?e, ui caaacia/o? aa?io
oaeo/?noue, aea ia iaaea? aenieeo i?oeieo yeinoae. Aeniea aa?o?noue
iaoa??ae?a aeey aa?iaoecaoe?? caei?aeiiiiai ae?iaieoeoaa ia?aoeiaeaea?
oe?ieiio ai?iaaaeaeaiith iaoiaeo ieanoeee aiae? aeey i?io?eaeoeee
o?no?iiai ea???no ae?oae. O ca’yceo c oeei canoinoaaiiy iaoiaeeee
aa?iaoecaoe?? o iao?e e?a?i? iaiaaeaia.

Oaeei /eiii, aeniea ?iciianthaeaeai?noue o?no?iiai ea???no iino?eieo
iiey??a o ae?oae oa a?aenooi?noue aeinooiieo a?o/eciyieo cania?a eiai
i?io?eaeoeee ?iaeyoue noai?aiiy iiaeo iaoa??ae?a aeey iiia?aaeaeaiiy
ea???no ieeethc?eieo iiaa?oiiue iaaecae/aeii aeooaeueieie oa
iaiao?aeieie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Aea?aiee iai?yiie aeine?aeaeaiiy ca?aa?oueny c iai?yieii
iaoeiai-aeine?aeii? ?iaioe Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo “Eiiieaenia e?eoaaiiy oai?eo c iaoieia??th uaeaiii-eeoeaai?
iaeano?”, iiia? aea?aeaaii? ?a?no?aoe?? — 01.98.0002619, oa
i?aeii?yaeeiao?oueny iaoeia?e i?ia?ai? eaoaae?e oa?aiaaoe/ii?
noiiaoieia?? Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
”?ic?iaea, aeine?aeaeaiiy oa oi?iaaaeaeaiiy cania?a e?eoaaiiy oa
i?io?eaeoeee caoai?thaaiue oaa?aeeo oeaiei coa?a oa neeciai? iaieiiee
ii?iaeieie ?ioa”.

Iaoa ? caaea/? aeine?aeaeaiiy

Iaoith aeaii? ?iaioe ? i?io?eaeoeea o?no?iiai ea???no c aeei?enoaiiyi
iiaiai a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea “Aeaioaeaen- 11O”.

?aae?caoe?y iinoaaeaii? iaoe aeiaaa? ae??oaiiy oaeeo caaaeaiue:

1. Iaa?oiooaaoe neeaae a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea.

2. I?iaanoe eaai?aoi?ia aeine?aeaeaiiy o?ceei-iaoai?/ieo oa o?i?/ieo
aeanoeainoae cai?iiiiiaaiiai neeaaeo aa?iaoeea.

3. I?iaanoe eaai?aoi?ia aea/aiiy aca?iiae?? cai?iiiiiaaiiai aa?iaoeea c
oaa?aeeie oeaieiaie coao.

4. Ioe?ieoe ee?i?/io aoaeoeai?noue iaoa??aeo oa ?ic?iaeoe ?aeiiaiaeaoe??
aei eiai canoinoaaiiy o noiiaoieia?/i?e i?aeoeoe?.

5. Iaa?oiooaaoe niin?a i?io?eaeoeee o?no?iiai ea???no c aeei?enoaiiyi
a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea oa ?ai?ia?ae?coth/iai caniao
i?ieiiaiaaii? ae??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa: — ia no/aniiio iaoeiaiio ??ai? noai?aii iiaee a?o/eciyiee
ooi?ai?uoth/ee oioiiie?ia?iee iaoa??ae aeey aa?iaoecaoe?? o?no?
“Aeaioaeaen-11O”;

— cae?eniai? eaai?aoi?i? aeine?aeaeaiiy aa?iaoeea
“Aeaioaeaen-11O”;

— i?iaaaeai? ee?i?/i? niinoa?aaeaiiy oa ioe?iaia aoaeoeai?noue
a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea aeey i?io?eaeoeee o?no?iiai
ea???no;

— ?ic?iaeaii iiaee niin?a i?io?eaeoeee o?no?iiai ea???no c
aeei?enoaiiyi aa?iaoeea “Aeaioaeaen-11O” oa ?ai?ia?ae?coth/eo aeene?a
“Ooi?ae?oineaeue”.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

Aeey iio?aa i?aeoe/ii? ioi?iie caei?ia’y noai?aiee oa aea/aiee
a?o/eciyiee i?aia?ao o aeaeyae? aa?iaoeea-oioiiie?ia?a aeey
aa?iaoecaoe?? o?no?, yeee ai?uo? ooi? oa ia? aenie? i?oei?
oa?aeoa?enoeee. ?ic?iaeaia ?ino?oeoe?y aei canoinoaaiiy aa?iaoeea
“Aeaioaeaen-11O”.

?ic?iaeaii iiaee niin?a i?io?eaeoeee o?no?iiai ea???no iino?eieo
coa?a o ae?oae c aeei?enoaiiyi aa?iaoeea “Aeaioaeaen — 11O” oa
?ai?ia?ae?coth/iai caniao i?ieiiaiaaii? ae??.

?aaeoeoe?y o?no?iiai ea???no i?e canoinoaaiiy o ee?i?oe?: — aa?iaoeea
“Aeaioaeaen-11O” neeaaea? 91%; iiaiai niiniao i?io?eaeoeee o?no?iiai
ea???no — 96% .

Cae?eniaii ai?iaaaeaeaiiy ?ic?iaeaiiai aa?iaoeea “Aeaioaeaen-11O” o
ae?iaieoeoai. Ae?iaiee AO “Noiia”, i. Oa?e?a.

Iniaenoee aianie caeiaoaa/a

Iiaeai? o aeena?oaoe?? iaoa??aee ? aeaniei oa iniiaiei aianeii aaoi?a a
ii?aoeueiaaio i?iaeaio. Aaoi?ii i?iaaaeaiee iaoeiai-iaoaioiee iiooe ca
i?iaeaiith, ui aeine?aeaeoaaeanue. Aaoi? a?aa o/anoue o ?ic?iaoe? iiaiai
a?o/eciyiiai aa?iaoeea “Aeaioaeaen-11O”, iei naiino?eii i?iaaaeai?
eaai?aoi?i? aei?iaoaaiiy iaoa??aeo. I?e eaai?aoi?ieo aeine?aeaeaiiyo
aaoi? a?aa aaciina?aaeith o/anoue o aeeiiaii? aeaeo?iiii-i?e?ineii?/ieo,
?aae?i?cioiiieo, i?e?ia?ieia?/ieo aeine?ae?a. ?ic?iaeaiee niin?a
i?io?eaeoeee o?no?iiai ea???no c canoinoaaiiyi “Aeaioaeaen-11O” oa
aeene?a “Ooi?ae?oineaeue”. On? ee?i?/i? aeine?aeaeaiiy aoaeoeaiino?
?ic?iaeaiiai aa?iaoeea “Aeaioaeaen — 11O” aeeiiai? aaoi?ii naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

?acoeueoaoe aeine?aeaeaiiy aeiiia?aeaeeny ia: ?aa?iiaeuei?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? a/aieo-noiiaoieia?a iaaee/ieo aoc?a oa
i?aeoe/ieo e?ea??a o iaaeao iaoe?iiaeueii? aenoaaee c i?aeia?iaeiith
o/anoth (i.Oa?e?a, 1998 ?); ia eiioa?aioe??, i?enay/ai?e 20-??//th
noiiaoieia?/iiai oaeoeueoaoo Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo (i. Oa?e?a, 1998 ?.); ia ?aa?iiaeuei?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? a/aieo-noiiaoieia?a iaaee/ieo aoc?a oa i?aeoe/ieo e?ea??a o
iaaeao iaoe?iiaeueii? aenoaaee (i. Oa?e?a, 1999 ?.); ia can?aeaii?
Oa?e?anueeiai a?aeae?eaiiy Anioe?aoe?? noiiaoieia?a Oe?a?ie (i. Oa?e?a,
1999 ?.).

Ioae?eaoe??

Iioae?eiaaii 10 ?ia?o, ?c ieo: 5 noaoae o iaoeiaeo aeo?iaeao, 3 noaoo? o
ca??ieeao iaoeiaeo i?aoeue, 2 iiceoeaieo ??oaiiy i?i aeaea/o iaoaioo ia
aeiao?ae.

No?oeoo?a aeena?oaoe??

Aeena?oaoe?y neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e, o?ueio
?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e oa nieneo aeei?enoaieo aeaea?ae. ?iaioa aeeeaaeaia ia 160
noi??ieao iaoeiiieno, ?ethno?iaaia 53 iaethieaie, i?noeoue 6 oaaeeoeue.
Nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae i?noeoue 361 iaeiaioaaiiy.

Iniiaiee ci?no ?iaioe

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Aeey aeinyaiaiiy iinoaaeaii? iaoe oa aeeiiaiiy iia’ycaieo c iath
caaaeaiue i?iaaaeaia ?iaioa aeey iaa?oiooaaiiy neeaaeo aa?iaoeea c
aeei?enoaiiyi eiiieaeno eaai?aoi?ieo oa ee?i?/ieo aeine?aeaeaiue.

O i?ioean? noai?aiiy neeaaeo “Aeaioaeaen-11O” aoee canoiniaai?
iaoiaeeee, ye? aeicaieythoue ioe?ieoe iniiai? o?ceei-iaoai?/i? oa
o?i?/i? aeanoeaino? aa?iaoeea. Aeine?aeaeaiiy aoei i?iaaaeaii ia
eaai?aoi?ieo c?aceao iie?ia?ecao?a aa?iaoeea c ??ciei ai?noii
iaiiaithaa/ae ca caaaeueiii?eeiyoeie iaoiaeeeaie. [Ea?aeueiee Ae.I.,
1978; Ai?iia?aa E.A., 1986; Ao??/aaa C.A., Iao?iaa E.?., Nooa?aaa E.A.
oa ?i., 1977; AINO 4386-89, 1990]

Eaai?aoi?i? aeine?aeaeaiiy oa?aeoa?o aca?iiae?? c aiaeeth coa?a
?ic?iaeaiiai iaie aa?iaoeea-oioiiie?ia?a i?iaiaeeee ca aeiiiiiaith
iaoiaeo aeaeo?iiii? neaioth/i? i?e?ineii??. Aeey oeueiai aoei cae?eniaii
ii??aiyeueia aeine?aeaeaiiy nooiaiy ?aoaioe?? aa?iaoee?a ??ciiai oeio oa
“Aeaioaeaen-11O”, aecia/aiiy iniaeeainoae i?e?i?aeue?oo cii, ye?
ooai?ththoueny ia ??cieo aiaoii?/ieo ??aiyo aeoaaeueii? iiaa?oi? i?e
i?iaaaeaii? aeaeaeueoeeiaoe?? o i?ioean? aa?iaoecaoe??, oa nooi?iue
iie?eooy ?o aa?iaoeeii. Iaoa??aeii aeey aeaiiai aeine?aeaeaiiy neoaeeee
oe?oe na?aeiaeeo/aieo ca i?oiaeiioe/ieie iieacaiiyie coa?a — ?ioaeoieo
ia?oeo i?aiiey??a ae?oae o a?oe? 9-10 ?ie?a. O caeaaeiino? a?ae oe?e?
aeine?aeaeaiiy coae aoee ?iciiae?eai? ia 5 a?oi. O ia?oo a?oio oa?eoee
coae, o?no?e yeeo aoee caia/aoai? iaiaiiaiaiei aacooi?enoei aa?iaoeeii
o?i?/iiai oeio oaa?aeiaiiy “Aeaeueoii”, AO “Noiiaaeaio”, ?in?y. O ae?oao
a?oio iaae?eoee coae, ia?iaeai? iaiiaiaiei aacooi?enoei
aa?iaoeeii-oioiiie?ia?ii “Aeaioaeaen-10”. O?aoy a?oia neeaaeaeanue ?c
coa?a, o?no?e yeeo aoee caia/aoai? iaiiaiaiei aa?iaoeeii-oioiiie?ia?ii,
yeee i?noeoue ooi?, “Aeaioaeaen — 11O”. *aoaa?oa a?oia neeaaeaeanue ?c
coa?a, ia yeeo aoa canoiniaaiee ?ic?iaeaiee iaie niin?a aa?iaoecaoe??,
ui aeeth/aa aeiaeaoeiao aei caia/aooaaiiy o?no? aa?iaoeeii
“Aeaioaeaen-11O” ia?iaeo ioi/oth/i? i?io?aaeaii?, aea ia ae?eoi?
iaoa??aeii ae?eyiee aiae?, ?ai?ia?ae?coth/ei aeeneii. O oeueiio iai?yieo
aea/aee ci?io o no?oeoo?? aeacaieo ae?eyiie aiae? i?ney canoinoaaiiy
aeaiiai niiniao. Eiio?ieue ca ye?noth aeaeaeueoeeiaoe?? aoei i?iaaaeaii
ia i’yo?e a?oi? coa?a, aiaeue yeeo aoea ia?iaeaia o?eueee eeneioith a
oiiaao, ye? a?aeiia?aeathoue oei, ui aoee canoiniaai? o ee?i?oe? i?e
i?iaaaeaii? aa?iaoecaoe?? o?no?. C?acee aea/aee oa oioia?aooaaee o
neaioth/iio aeaeo?iiiiio i?e?ineii? (NAI) ?AI-100J i?e i?enei?thth/?e
iai?oc? 15 eA, i?e ca?eueoaii? cia?aaeaiiy a?ae 50 aei 2000 ?ac?a
[Aeaoeiaa I.I., 1983].

Aeey i?aeoaa?aeaeaiiy aeinoia??iino? aeaieo aeaeo?iiii? neaioth/i?
i?e?ineii?? oa aea/aiiy e?aeiaiai i?eeyaaiiy aa?iaoee?a iaie aoa
canoiniaaiee iaoiae aaoi?aae?ia?ao??. Aeey oeueiai aoee aeei?enoai?
na?aeiaeeo/ai? ca i?oiaeiioe/ieie iieacaiiyie ?ioaeoi? ia?o? i?aiiey?e.
Ioe?ieo nooiaiy e?aeiai? i?iieeiino? aa?iaoee?a ia ?aae?iaaoia?aoao
i?iaiaeeee ca caaaeueiii?eeiyoith iaoiaeeeith [Ea?aeueiee Ae.I., 1978].

Aeey aecia/aiiy ci?i aaeni?aoe?? i?e?iaii? oei?e coaii? aeyoee ia
aeoaaeuei?e iiaa?oi? aoei ianoaaeaii 70 ae?oae a?eii a?ae 6 aei 8 ?ie?a.
O caeaaeiino? a?ae oa?i?io aeine?aeaeaiiy oa oeio neeaioa aoee aecia/ai?
iaeia eiio?ieueia oa /ioe?e aeine?aei? a?oie ae?oae, o eio?eo a?aee
aiae?c i?e?iaii? oei?e coaii? aeyoee: eiio?ieueia — c ?ioaeoii?
aeoaaeueii? iiaa?oi?; ia?oa — c aeoaaeueii? iiaa?oi?, o?no?e yei?
caia/aoai? aa?iaoeeii “Aeaioaeaen-10” 10 ae?a oiio; ae?oaa — c
aeoaaeueii? iiaa?oi?, o?no?e yei? caia/aoai? aa?iaoeeii “Aeaioaeaen-10”
2 i?nyoe? oiio; o?aoy — c aeoaaeueii? iiaa?oi?, o?no?e yei? caia/aoai?
aa?iaoeeii “Aeaioaeaen-11O” 10 ae?a oiio; /aoaa?oa — c aeoaaeueii?
iiaa?oi?, o?no?e yei? caia/aoai? aa?iaoeeii “Aeaioaeaen-11O” 2 i?nyoe?
oiio. Caa?? iaoa??aeo, eiai o?ainii?ooaaiiy, aeae?eaiiy oa
?aeaioeo?eaoe?y i?e?ii?aai?ci?a coaii? aeyoee a?aeaoaaeeny ca?aeii c
caaaeueiii?eeiyoeie iaoiaeeeaie [Oioeo Ae., E?ea I., Nieo I., 1997;
A?eica?nueeee A.?., 1996].

Aoaeoeai?noue oa aeioe?euei?noue ee?i?/iiai canoinoaaiiy aa?iaoeea
“Aeaioaeaen-11O” aeey i?io?eaeoeee o?no?iiai ea???no ioe?ithaaee o aeaio
iai?yieao: aecia/aiiy ?iaeaeno caa?aaeaiiy aa?iaoeea i?ioyaii 1,5 ?ieo
oa ?aaeoeoe?? o?no?iiai ea???no coa?a, ye? aoee caaa?iaoeciaai?. Ioe?ieo
ea???ni?io?eaeoe/ii? ae?? ?ic?iaeaiiai iaie niiniao i?io?eaeoeee
o?no?iiai ea???no i?iaiaeeee oeyoii aecia/aiiy ?aaeoeoe?? o?no?iiai
ea???no coa?a a?oie aeine?aeo.

?ic?iaeaiee iaie niin?a i?io?eaeoeee o?no?iiai ea???no iieyaaa o oiio,
ui i?ney ieanoeee aiae? aa?iaoeeii “Aeaioaeaen — 11O” i?iaiaeeeanue
aeiaeaoeiaa ia?iaea aeoaaeueii? iiaa?oi? iaaeiei aa?iaoeea
?ai?ia?ae?coth/eie aeeneaie “Ooi?ae?oineaeue” o e?eueeino? 5 i?ioeaaeo?
/a?ac aeiao. Ia aeaiee niin?a i?io?eaeoeee o?no?iiai ea???no iaie
io?eiaia iiceoeaia ??oaiiy i?i aeaea/o iaoaioo ia aeiao?ae ii
cayaoe? ? 98010530, a?ae 12.11.1998 ?.

Ee?i?/i? aei?iaoaaiiy i?iaiaeeeeny ia 2 a?oiao ae?oae. Aei ia?oi?

aoiaeeei 160 ae?oae 6-8 ?ie?a, o yeeo i?aeeyaaee aa?iaoecaoe??
“Aeaioaeaen-11O” 320 ia?oeo iino?eieo iiey??a aa?oiuei? oa ieaeiuei?
uaeaie i?aai? noi?iie. A?aeiia?aei? coae e?ai? noi?iie aoee ia?ai? ye
eiio?ieue. Ae?oao a?oio neeaaeaee 90 ae?oae, o yeeo 180 ia?oeo iino?eieo
iiey??a aa?oiuei? oa ieaeiuei? uaeaie i?aai? noi?iie aoee ia?iaeai?
ca?aeii c cai?iiiiiaaiei niiniaii i?io?eaeoeee o?no?iiai ea???no.
A?aeiia?aei? coae i?ioeeaaeii? noi?iie aoei ia?aii ye eiio?ieue.
Eiio?ieuei? iaeyaee i?iaiaeeee /a?ac 6, 12, 18 i?nyoe?a.

?acoeueoaoe eaai?aoi?ii-ee?i?/ieo niinoa?aaeaiue ia?iaeai? iaoaiaoe/ieie
iaoiaeaie aa??aoe?eii? noaoenoeee c i?eoyaiaiiyi IAII ca Nouethaeaioii,
Aaianii [Ei?i A., Ei?i O., 1978; Aaian A.N. ? ni?aaao., 1986].

?acoeueoaoe aeanieo aeine?aeaeaiue

Aeey iniiae ?aoeaioo?e ooi?ai?uoth/iai aa?iaoeea “Aeaioaeaen — 11O” aoei
?ic?iaeaii ?aoeaioo?o caniao aeey aa?iaoecaoe?? o?no? ia iniia?
a?n-aia, yeee a?ae??ciyany oei, ui aeiaeaoeiai aeeth/aa
A?n-/iaoae?eeieneaoeeaiea?aiiao/ae?aoeeaiaeeeieue, yeee caaacia/oaaa
aenieee ??aaiue aaeaac?? oa canoiniaoaaany ye ?ic??aeaeoaa/ a?n-aia, a
oaeiae iaeaiee ieaaeaiee eaa?oe ai?aoiaaiee, eaioi?io?iii, i?e oaeiio
ni?aa?aeiioaii? eiiiiiaio?a, ian%:

· A?n/3-iaoae?eeiene-2

ienei?iiiene-4-oai?e/i?iiai 22,8 — 25,2

· A?n-/iaoae?eeieneao?eaiea?aiiao/

ae?aoeeaiaeeeiey 22,8 — 25,2

· Iaeaiee ieaaeaiee eaa?oe ai?aoiaaiee 48,93-54,08

· Eaioi?io?iii 0,14 — 0,16

Iiceoeaia ??oaiiy i?i aeaea/o iaoaioo ia aeiao?ae ii cayaoe? ? 97126006,
a?ae 12.10.1998?.

O i?ioean? ?ic?iaee ?aoeaioo?e ooi?ai?uoth/iai aa?iaoeea “Aeaioaeaen
-11O” iaie aoea i?iaaaeaia cai?ia iaeaiiai ieaaeaiiai eaa?oeo
ai?aoiaaiiai ia ai?aoiaaiee neeiiaiiaithaa/, yeee ia? e?io? oaoiieia?/i?
aeanoeaino?, iioe/i? ? o?ceei-iaoai?/i? iieacieee, iaaeeaeai? aei
yeinoae coaa. Aeai? aea/aiiy o?ceei-iaoai?/ieo iieaciee?a eaai?aoi?ieo
c?ace?a iie?ia?ecao?a aa?iaoeea c ??ciei ai?noii neeiiaiiaithaa/a
i?eaaaeai? o oaaeeoe? 1 ? na?ae/aoue i?i oa, ui naia 50% ai?no
neeiiaiiaithaa/a caaacia/o? iaea?eueo aenieo iaoai?/io no?ee?noue aei
iai?oaeaiiy oa ? iioeiaeueiei aeey iiaeaeueoiai aea/aiiy.

Oaaeeoey 1

?acoeueoaoe o?ceei-iaoai?/ieo aei?iaoaaiue aeine?aeieo eaai?aoi?ieo
c?ace?a c ??ciei ai?noii iaiiaithaa/a

Aeae aei?iaoaaiiyEaai?aoi?iee c?acieAeeaeia caoaa?ae?iiy,

iiI?e?i-oaa?ae?noue, I/ii2?oeioth/a iai?oaeaiiy i?e noeniaii?,
IIaAiaeiiiaee-iaiiy, iea/ii320%

neeiiaiiaithaa/a5,84±0,23120,9±6,17157,2±7,7122,2±0,8830%
neeiiaiiaithaa/a6,1±0,27139,1±5,56166,8±8,3421,3±1,0250%

neeiiaiiaithaa/a4,94±0,25264,4±11,89189,7±7,317,9±0,32

Ianooiiei aoaiii o ?ic?iaoe? ?aoeaioo?e aa?iaoeea “Aeaioaeaen-11O” noaei
aecia/aiiy eiioeaio?aoe?? oa aaaaeaiiy i?ioeea??iciiai caniao o aeaeyae?
ooi?eaeo iao??th o neeaae aa?iaoeea, a oaeiae aea/aiiy iiaeeeaino? eiai
ca?eueiaiiy ?c iie?ia?ecaoa. sse ?ioaa?aeueiee iieaciee oeueiai i?ioeano
aoea ia?aia oaeaee?noue aeno?aeoe?? ooi?eae-?ii?a ?c iie?ia?ecao?a. O
i?ioean? aeine?aeaeaiiy aoei aeyaeaii, ui i?e iioeiaeuei?e 50%
eiioeaio?aoe?? iai?aai?/iiai iaiiaithaa/a o neeaae?, cai?ia 5% aai 2,5%
neeiiaiiaithaa/a ia ooi?eae iao??th nooo?ai ia aieeaa? ia i?oei?
aeanoeaino? iaoa??aeo. Aeai? o?ceei-iaoai?/ieo iieaciee?a iaio
aeine?aeieo a?oi c?ace?a, ye? a?aeiia?aeaee ii?iaoeaai i?aeia?iaeiiai
noaiaea?oo c iaaaeeeith ia?aaaaith neeaaeo c 5% ai?noii ooi?eaeo iao??th
ca iieacieeaie aiaeiiiaeeiaiiy oa eii?/ii? oi/ee oaeo/ino? iaaaaeai? o
oaaeeoe? 2.

Aea aeine?aeaeaiiy uiaei ni?iiiaeiino? iie?ia?ecaoo aa?iaoeea aeae?eyoe
ooi?eae-?ii o iiaeaeueia na?aaeiaeua aeiaaee, ui iioeiaeueiith
eiioeaio?aoe??th ooi?enoi? niieoee o aa?iaoeea ? 5% eiioeaio?aoe?y.
Aecia/aii, ui aeaiee neeaae ia? aeinoia??ii iaioee ii/aoeiaee aeo?ae
ooi?eae-?iio ?c iie?ia?ecaoo oa iia?eueiee eiai aeo?ae i?e iiaeaeueo?e
aca?iiae?? c iiaeaeueiith ??aeeiith. I?e i?aeoe/ii iaeiaeiaeo c
iiia?aaei?i neeaaeii o?ceei-iaoai?/ieo yeinoyo neeaae c 2,5% ai?noii
ooi?o ia? aeinoia??ii a?eueoee ii/aoeiaee aeo?ae ooi?eae-?iio.
Oaeaee?noue aeeooc?? ooi?eae-?iio o iiaeaeueia na?aaeiaeua o aeaio
a?oiao, ui aea/athoueny, aeinoia??ii ia a?ae??ciy?oueny, aea ai?no
ooi?eaeo iao??th o ia?o?e a?oi? o aeai? a?eueoee, oiio i?e iaeiaeia?e
oaeaeeino? /an eiai aeae?eaiiy cia/ii a?eueoee.

Oaeei /eiii, io?eiai? ?acoeueoaoe aeicaieythoue aaaaeaoe, ui
o?ceei-iaoai?/i? aei?iaoaaiiy eaai?aoi?ieo c?ace?a na?ae/aoue i?i aenie?
i?oei? yeino? iaoa??aeo. A?aoiaoth/e oie oaeo, ui ieeethc?ei? iiaa?oi?
i?aeeyaathoue iaea?eueoei iaoai?/iei iaaaioaaeaiiyi, iiaeia c?iaeoe
aeniiaie, ui iineeaia i?oei?noue aoaea ni?eyoe o?eaaeiio caa?aaeaiith
aa?iaoeea o o?no??. ?ic?iaeaiee iaie aa?iaoee c 45% ai?noii
neeiiaiiaithaa/a ? 5% ai?noii ooi?eaeo iao??th ae?? ye ?aca?aoa? ?ii?a
ooi?o oa ieiiaoaaeueiee aaaio.

Oaaeeoey 2

?acoeueoaoe o?ceei-iaoai?/ieo aei?iaoaaiue aeine?aeieo eaai?aoi?ieo
c?ace?a c ??ciei ai?noii ooi?eaeo iao??th

Aeae aei?iaoaaiiyEaai?a-oi?iee c?acieAeeaeia caoaa?ae?iiy,
iiI?e?i-oaa?ae?noue, I/ii2?oeioth/a iai?oaeaiiy i?e noen-iaii?,
IIaAiaei-iiaeeiaiiy, iea/ii3Eii?/ia oi/ea oaeo/ino?,

IIa5% NaF

45% neeiiaiia-ithaa/a4,2 ±0,17281,3 ±11,24162,6 ±8,137,4 ±0,28913,5
±40,42,5% NaF

47,5% neeiiaiia-ithaa/a4,1 ±0,16278,1 ±11,12148,5 ±7,4012,2 ±0,72761,1
±37,6

Aeei?enoaiiy aa?iaoeea “Aeaioaeaen-11O” o iaaee/i?e i?aeoeoe? oa eiai
na??eia ae?iaieoeoai aeicaieai? Eii?oaoii c iiai? iaaee/ii? oaoi?ee IIC
Oe?a?ie (i?ioieie can?aeaiiy ? 3 a?ae 31.03.99 ?.).

I?e ii?oieia?/ieo aeine?aeaeaiiyo iaoiaeii aeaeo?iiii? i?e?ineii?? aoei
aeyaeaii, ui iaiaiiaiaiee aa?iaoee “Aeaeueoii” ia iaa u?eueiiai
e?aeiaiai eiioaeoo. O an?o aeiaaeeao aeine?aeaeaiiy niinoa??aaeany
iayai?noue e?aeiai? u?eeie ia iiia?a/ieo oe?oao oa o??uei, ?ic?ea?a,
aeaoaeo?a o oiau? aa?iaoeea ia iicaeiaaei?o oe?oao. Aa?iaoeee
“Aeaioaeaen-10” oa “Aeaioaeaen-11O” ia iiia?a/ieo oe?oao ii an???
iiaa?oi? aeine?aeaeaiiy iaee u?eueiee e?aeiaee eiioaeo ? ooai?thaaee
u?eueiee ca’ycie c aiaeaaith iiaa?oiath o o?no??, yeee niinoa??aaany ia
iicaeiaaei?o oe?oao coa?a. Aeaoaeoe o oiau? iaiaiiaiaiiai aa?iaoeea
o?i?/iiai oeio oaa?aeiaiiy oa iayai?noue e?aeiai? u?eeie i?ae aa?iaoeeii
oa aeoaaeueiith iiaa?oiath na?ae/aoue i?i aaeeeee ??aaiue
iie?ia??caoe?eii? onaaeee. ?ao?aeoe?ei? i?ioeane o iaoa??ae?
ooai?ththoue ?icaeoie oaiaaioe?aeueieo iai?oaeaiue o iaoa??ae?, ui
iaoiiaeth? aeyaeai? aeaoaeoe. Iayai?noue aaeeei? e?eueeino? iaiiaithaa/a
o neeaae? aa?iaoee?a “Aeaioaeaen-10” oa “Aeaioaeaen-11O”ni?ey?
ciaioaiith onaaeee o i?ioean? iie?ia?ecaoe??. E??i oiai, caoaa?ae?iiy
aeaieo aa?iaoee?a a?aeaoaa?oueny “ii eiiaiae?”, ui aea? iiaeeea?noue
?aoaeueii ?iciiae?eeoe iaoa??ae ii o?no?? aei ii/aoeo i?ioeano
iie?ia?ecaoe??, ia a?aei?io a?ae neeaio?a o?i?/iiai oeio caoaa?ae?iiy.

Aeine?aeaeaiiyi aeoaaeueii? iiaa?oi? coa?a i?ney aa?iaoecaoe?? ca
aeiiiiiaith NAI aoei aeiaaaeaii, ui o eiaeiiio aeiaaeeo niinoa?aaeaiiy
iaaeiei aa?iaoeea aecia/a?oueny ciia aeaeaeueoeeiiaaii?, aea ia iie?eoi?
iaoa??aeii aiae?. Caaaeyee ia?iaoe? aiae? iaaeiei aa?iaoeea
?ai?ia?ae?coth/eie aeeneaie “Ooi?ae?oineaeue” ia ?? iiaa?oi?
ooai?th?oueny caoeniee oa?, yeee iiia?aaeaeo? o?aaeaiiy aeaii? ciie.

Aeinoia??i?noue aeaieo, yee aoee io?eiai? i?e aeine?aeaeaii? o NAI,
i?aeoaa?aeeee ?acoeueoaoe aea/aiiy e?aeiaiai i?eeyaaiiy ??cieo aeae?a
aa?iaoee?a iaoiaeii aaoi?aae?ia?ao??. Oae, iaiaiiaiaiee aa?iaoee
o?i?/iiai oeio oaa?aeiaiiy “Aeaeueoii” /a?ac 2 i?nyoe? niinoa?aaeaiiy
/a?ac aeaoaeoe o aiaeaai-iie?ia?iiio aeioe? iaa i?iieeiaiiy 45Na aei
aeia caaeeaeie. Iaiiaiaiee neeaio — oioiiie?ia? “Aeaioaeaen — 11O” /a?ac
cacia/aiee oa?i?i iaa i?iieeiaiiy ?cioiio eeoa ia e?i?? cieeaiiy c
aeoaaeueiith iiaa?oiath, ui na?ae/eoue i?i eiai e?au? ?aoaioe?ei?
aeanoeaino?.

O i?ioean? aea/aiiy aaeni?aoe?? i?e?iaii? oei?e coaii? aeyoee iaie
aecia/aii aeinoia??ia ciaioaiiy aeie? Str. mutans o o?ao?e oa /aoaa?o?e
a?oiao aeine?aeo, 3,6% oa 4,1% a?aeiia?aeii, o ii??aiyii? c cacia/aieie
iieacieeaie eiio?ieueii?, ia?oi? oa ae?oai? a?oi aein-e?aeo, 28%,
23,7%, 24,1 a?aeiia?aeii (? < 0,05). Ciaioaiiy aaeni?aoe?? Str. mutans ia iiaa?oi? coa?a c ooi?ai?uoth/ei neeaioii iiina?aaeeiaaii aeiaiaeeoue i?ieiiaiaai?noue aeae?eaiiy ooi?eae-?ii?a ?c iie?ia?ecao?a. ?acoeueoaoe aea/aiiy ?aoaioe?eieo aeanoeainoae aa?iaoeea “Aeaioaeaen-11O” o ee?i?oe?, cie?aia ?iaeaeno eiai caa?aaeaiiy, iaaaaeai? o oaaeeoe? 3. Io?eiai? aeai? na?ae/aoue, ui /a?ac 6 i?nyoe?a ?iaeaen caa?aaeaiiy aa?iaoeea neeaa o ia?o?e i?io?eaeoe/i?e a?oi? ae?oae 0,95 0,012, i?e oeueiio iie?eooy ao?aoeee 16 coa?a, o ae?oa?e i?io?eaeoe/i?e a?oi? 0,960,014, i?e oeueiio iie?eooy ao?aoeee 7 coa?a. I?ney 12 i?nyoe?a niinoa?aaeaiiy caa?aaeaiiy aa?iaoee?a neeaaeaei ?iaeaene 0,93 0,014 oa 0,940,017, i?e ao?aoao aa?iaoee?a ia 6 ? 4 coaao aeey 1 oa 2 a?oi a?ae-iia?aeii. *a?ac 18 i?nyoe?a aa?iaoee aoei ao?a/aii o 29 aeiaaeeao o 1 i?io?eaeoe/i?e a?oi? oa o 14 aeiaaeeao o 2 i?io?eaeoe/i?e a?oi?, ui nooo?ai ia a?ae??ciyeiny. Oaaeeoey 3 ?iaeaen caa?aaeaiiy aa?iaoeea “Aeaioaeaen-11O” ia?oeo iino?eieo iiey??a ae?oae Na?aaeiy e?euee?noue iiey??a, ia yeeo caa?aaeaia iie?eooy ia iaeei coaA?oiaE?eue-e?noue E?euee?noue ia?iaeaieo6 i?nyoe?a12 i?nyoe?a18 i?nyoe?aae?oaeae?oaeaa?iaoeeii iiey??aE?eue-e?noue coa?a?iaeaen caa?aaeaiiy aa?iaoeeaE?eue-e?noue coa?a?iaeaen caa?aaeaiiy aa?iaoeeaE?eue-e?noue coa?a?iaeaen caa?aaeaiiy aa?iaoeeaIa?oa1603203040,95± 0,0122980,93 ± 0,0142910,91 ± 0,015Ae?oaa901801730,96± 0,0141690,94 ± 0,0171660,92 ± 0,02Aeai? aea/aiiy ?aaeoeoe?? o?no?iiai ea???no iaaaaeai? o oaaeeoe? 4. *a?ac 6 i?nyoe?a ea??icieo o?aaeaiue o coaao aeine?aeii? noi?iie iaio a?oi ae?oae ia aoei aecia/aii. Coae eiio?ieth o ae?oae 1 a?oie iaee ?iaeaen ea??iciino? 0,1 0,03, oiaoi 32 aeiaaeee ea???no. O 2 a?oi? - 0,110,04, oiaoi 21 aeiaaeie ea??icieo o?aaeaiue. ?aaeoeoe?y o?no?iiai ea???no neeaea 100%. *a?ac 12 i?nyoe?a niinoa?aaeaiiy a coaao aeine?aeii? noi?iie iaio i?io?eaeoe/ieo a?oi ae?oae ia aoei aeyaeaii aeiaeiiai ea??iciiai o?aaeaiiy. Coae eiio?ieth 1 a?oie iaee ?iaeaen ea??iciino? 0,25 0,05, oiaoi 80 aeiaaee?a ea??icieo o?aaeaiue, o 2 a?oi? - 0,21 0,06, oiaoi 38 aeiaaee?a ea??icieo o?aaeaiue, ui ia neeaaea? aeinoia??ii? ??cieoe?. ?aaeoeoe?y o?no?iiai ea???no neeaaeaea 100%. *a?ac 18 i?nyoe?a niinoa?aaeaiiy ia aeine?aei?e noi?ii? o ae?oae 1 i?io?eaeoe/ii? a?oie aoei ca?a?no?iaaii 16 ea??icieo o?aaeaiue c e?eueeino? 29 coa?a, ui ao?aoeee iie?eooy. O ae?oae ae?oai? a?oie ea???n aoei aeyaeaii o 3 aeiaaeeao ?c 14 coa?a, ui ao?aoeee neeaio. O 1 oa 2 a?oiao e?euee?noue ea??icieo coa?a eiio?ieueii? noi?iie neeaaeaea 168 oa 72 a?aeiia?aeii. ?aaeoeoe?y o?no?iiai ea???no i?ney 18 i?nyoe?a neeaaeaea o ia?o?e i?io?eaeoe/i?e a?oi? 91%, o 2 a?oi? - 96%, ui ? aeinoia??iith ??cieoeath. ?acoeueoaoe aea/aiiy aoaeoeaiino? aa?iaoeea “Aeaioaeaen-11O” oa ?ic?iaeaiiai niiniao i?io?eaeoeee o?no?iiai ea???no aeiaaee, ui aeiaeaoeiaa ia?iaea ?ai?ia?ae?coth/ei aeeneii iiaa?oi? iaaeiei aa?iaoeea i?eaiaeeoue aei ca?eueoaiiy iieacieea ?aaeoeoe?? o?no?iiai ea???no ca ?aooiie cieaeaiiy ea??icieo o?aaeaiue coa?a, ui ao?aoeee aa?iaoee. Oaeei /eiii, o ?acoeueoao? i?iaaaeaiiai eaai?aoi?ii-ee?i?/iiai aeine?aeaeaiiy ?ic?iaeaii ?aoeaioo?o iiaiai a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea-oioiiie?ia?a "Aeaioaeaen-11O". Cacia/aiee iaoa??ae ia? aenie? o?ceei-iaoai?/i? iieacieee, ni?iiiaeiee aeno?aaoaaoe ?iie ooi?o ?c iie?ia?ecao?a. Anoaiiaeai? eiai aenie? ?aoaioe?ei? aeanoeaino?, iiaeeea?noue ooai?aiiy u?eueiiai eiioaeoo c aiaeeth coaa, ui caaacia/o? aenieee ??aaiue e?aeiaiai i?eeyaaiiy aa?iaoeea oa iaae?eio iaoo?aoe?th caaeeaei. Aecia/aii ciaioaiiy aaeni?aoe?? Str. mutans ia aeoaaeuei?e iiaa?oi? coao, yea aoea ia?iaeaia aa?iaoeeii “Aeaioaeaen - 11O” o ii??aiyii? ?c ?ioaeoiith aeoaaeueiith iiaa?oiath oa aeoaaeueiith iiaa?oiath coao, yea aoea ia?iaeaia aacooi?enoei neeaioii "Aeaioaeaen-10". Aeiaaaeaii ee?i?/io aoaeoeai?noue ?ic?iaeaiiai aa?iaoeea oa niiniao i?io?eaeoeee o?no?iiai ea???no c canoinoaaiiyi aa?iaoeea "Aeaioaeaen-11O". ?aoaioe?ei? aeanoeaino? iaoa??aeo o ee?i?oe? aeine?aeaeai? ia 250 iaoe??ioao, yeei aoee caaa?iaoeciaai? 500 ia?oeo iino?eieo iiey??a. ?iaeaen caa?aaeaiiy aa?iaoeea neeaaeaa 0,91± 0,015 oa 0,92 ± 0,02 o aeaio i?io?eaeoe/ieo a?oiao ae?oae. ?aaeoeoe?y o?no?iiai ea???no i?e aeei?enoaii? aa?iaoeea "Aeaioaeaen-11O" ye naiino?eiiai caniao i?io?eaeoeee o?no?iiai ea???no neeaea 91%. Canoinoaaiiy cacia/aiiai iaoa??aeo o iaaeao cai?iiiiiaaiiai niiniao i?io?eaeoeee o?no?iiai ea???no i?eaaei aei ?aaeoeoe?? ea???no, ui neeaea 96%. Ioaea, a ?acoeueoao? aeeiiaiiai aeine?aeaeaiiy aeiaaaeaia aoaeoeai?noue a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea "Aeaioaeaen-11O" ye caniao i?io?eaeoeee o?no?iiai ea???no. Aeniiaee 1. Aia?oa aeey iio?aa i?aeoe/ii? ioi?iie caei?ia’y ?ic?iaeaii oa iaa?oioiaaii neeaae a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea-oioiiie?ia?a “Aeaioaeaen - 11O”, ia iniia? a?n-aia, yeee i?noeoue 45% ai?aoiaaiiai neeiiaiiaithaa/a oa 5% ooi?eaeo iao??th. 2. Ca iane?aeeaie eaai?aoi?ieo aeine?aeaeaiue aeiaaaeaii aenie? i?oei? aeanoeaino? aa?iaoeea “Aeaioaeaen - 11O” (aeeaeia caoaa?ae?iiy - 4,2 ± 0,17 ii, i?e?ioaa?ae?noue - 281,3 ± 11,24 I/ii2, ?oeioth/a iai?oaeai-iy i?e noeniaii? - 162,6 ± 8,13 IIa, aiaeiiiaeeiaiiy - 7,4 ± 0,28 iea/ii3 , eiie/ia oi/ea oaeo/ino? - 913,5 ± 40,4 IIa) oa iiaeeea?noue aeno?aeoe?? ooi?eae-?ii?a c iie?ia?ecaoo. 3. O eaai?aoi?ieo oiiaao aeiaaaeaii aenie? ?aoaioe?ei? aeanoeaino? aa?iaoeea “Aeaioaeaen - 11O”, aenieee ??aaiue e?aeiaiai i?eeyaaiiy iaoa??aeo, ciaioaiiy ea???niaaiieo aeae?a i?e?ii?aai?ci?a coaii? aeyoee aeoaaeueii? iiaa?oi? ia?oeo iino?eieo iiey??a i?ae eiai aieeaii. 4. Ia iniia? ee?i?/ieo aeine?aeaeaiue ?aoaioe?eieo aeanoeainoae aa?iaoeea “Aeaioaeaen - 11O” anoaiiaeaii ?iaeaen caa?aaeaiiy iaoa??aeo /a?ac 6 i?nyoe?a - 0,95±0,012, /a?ac iaeei ??e - 0,93±0,014, /a?ac i?aoi?a ?ieo - 0,91±0,015, ui i?aeoaa?aeaeo? aenie? ?aoaioe?ei? aeanoeaino? iiaiai a?o/eciyiiai ooi?ai?uoth/iai iaoa??aeo aeey i?io?eaeoeee o?no?iiai ea???no “Aeaioaeaen - 11O”. 5. ?aaeoeoe?y o?no?iiai ea???no i?e aeei?enoaii? eeoa iaeiiai aa?iaoeea “Aeaioaeaen - 11O” /a?ac iaeei ??e neeaaeaea 100%, /a?ac i?aoi?a ?ieo - 91%, a i?e aeei?enoaii? oiai ae aa?iaoeea ni?eueii c ?ai?ia?ae?coth/eie aeeneaie “Ooi?ae?oineaeue”, neeaaeaea /a?ac iaeei ??e 100%, /a?ac i?aoi?a ?ieo - 96%. 6. ?ic?iaeaii niin?a i?io?eaeoeee o?no?iiai ea???no c aeei?enoaiiyi iiaiai a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea-oioiiie?ia?a “Aeaioaeaen-11O” ? ?ai?ia?ae?coth/eo aeene?a “Ooi?ae?oineaeue”. I?aeoe/i? ?aeiiaiaeaoe?? 1. Aeei?enoiaoaaoe iiaee a?o/eciyiee ooi?ai?uoth/ee aa?iaoee-oioiiie?ia? "Aeaioaeaen-11O" aeey ianiai? i?io?eaeoeee o?no?iiai ea???no. 2. I?e i?iaaaeaii? ieanoeee aiae? aa?iaoeeii "Aeaioaeaen-11O" o?aaa i?eae?eyoe iniaeeao oaaao ianooiiei iiiaioai: · caaacia/eoe ?aoaeueia aeaeaeaiiy coaii? aeyoee c iiaa?oi? aiae?, yea i?aeeyaa? aa?iaoecaoe??; · i?iaiaeeoe aaeaeaaoio eeneioio ia?iaeo aiae?, yea i?aeeyaa? aa?iaoecaoe?? - 37% ?ic/eiii i?oioinoi?ii? eeneioe i?ioyaii 30 naeoiae; · caaacia/eoe ?aoaeueia aeaeaeaiiy eeneioiiai aaaioa c iiaa?oi? aiae? - i?ioyaii 30 naeoiae i?iieaaoe aeoaaeueio iiaa?oith aiaeith; · i?iaiaeeoe ieanoeeo aiae? aa?iaoeeii “Aeaioaeaen - 11O” o iiai?e ?cieyoe?? a?ae neeie. 3. Aeei?enoiaoaaoe ?ic?iaeaiee niin?a i?io?eaeoeee o?no?iiai ea???no c canoinoaaiiyi aa?iaoeea “Aeaioaeaen - 11O” oa iaeii/aniith ia?iaeith aeai?ia?ae?ciaaii? aiae? iaaeiei aa?iaoeea ?ai?ia?ae?coth/ei aeeneii “Ooi?ae?oineaeue”. 4. Eiio?ieuei? iaeyaee caaa?iaoeciaaieo iiaa?oiae ne?ae i?iaiaeeoe c /anoioith 1 ?ac ia i?a??//y. Ia?ae?e iniiaieo ?ia?o, iaae?oeiaaieo ca oaiith aeena?oaoe?? 1. Iaca?yi ?.N. Eeeie/aneay ioeaiea aa?iaoeeia “Aeaioaeaen - 10” e “Oenno?eo - O” i?e iaeiaaceaiie aa?iaoecaoeee // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. - 1998. - aei. 24. - N. 123-126. 2. Iaca?yi ?.N. N?aaieoaeueiay oa?aeoa?enoeea eeeie/aneiai i?eiaiaiey aa?iaoeeia aeey i?ioeeaeoeee ea?eana oenno? // Iaaeeoeeia naaiaeiy e caao?a. - Oa?ueeia. - 1998. - a. 3. - N. 80. 3. Iaca?yi ?.N. ?iniianthaeaeai?noue oa oaeoi?e ?eceeo o?no?iiai ea???no iino?eieo coa?a o ae?oae // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. - 1998. - aei. 24. - N. 115-118. 4. Iaca?yi ?.N. I?ioeeaeoeea ea?eana aa?iaoecaoeeae oenno? coaia // Iaaeeoeeia naaiaeiy e caao?a. - Oa?ueeia. - 1998. - a. 3. - N. 3-5. 5. Iaca?yi ?.N. Ii?oieiae/aneay oa?aeoa?enoeea oeueo?ano?oeoo?-iiai acaeiiaeaenoaey aa?iaoeeia n yiaeueth coaa i?e ?aciuo ?aaeeiao aa?iaoecaoeee // Aii?inu yenia?eiaioaeueiie e eeeie/aneie noiiaoieiaeeth - 1998. - aui.1. N. 43-45. 6. Iaca?yi ?.N. Iaoiaee ae?aaiinoeee o?no?iiai ea???no // Iaaeeoeeia naaiaeiy e caao?a. - 1998. - ?. 1. - N. 169 - 173. 7. Nazaryan R.S. Changes of micro-hardness of stomatolodgic sealant with different content of filler in its composition // School of Fundamental Medicine Journal. - 1999. -vol. 5. - ? 1. - C.20-21. 8. Iaca?yi ?.N. Ii??aiyeueia ii?oieia?/ia oa?aeoa?enoeea ?aoaioe?eieo aeanoeainoae ??cieo aeae?a aa?iaoee?a// A?niee ii?oieia??. - 1999. - ?1. - o.5. - N.39-40. 9. ??oaiiy i?i aeaea/o iaoaioo ia aeiao?ae a?ae 12.10.98 ?., IIE 6A61N5/00 Aa?iaoee / Aie A.?., Eaoo?iaa A.O., Ai?iia?aa E.A., Iaca?yi ?.N., Aie TH.A.; Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao (UA). - ? 97126006; Cayae. 11.12.97. 10. ??oaiiy i?i aeaea/o iaoaioo ia aeiao?ae a?ae 12.11.98 ?., IIE 6A61N17/00 Niin?a i?io?eaeoeee ea???no o ae?oae ? i?aee?oe?a / Eaoo?i-aa A.O., Aaaeee O.A., Ai?iia?aa E.A., Iaca?yi ?.N.; Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao (UA). - ? 98010530; Cayae. 30.01.98. Aiioaoe?y Iaca?yi ?.N. ?ic?iaea oa iaa?oiooaaiiy canoinoaaiiy a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea “Aeaioaeaen-11O” (eaai?aoi?ii-ee?i?/ia aeine?aeaeaiiy) - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.22 - noiiaoieia?y. - Oe?a?inueea iaaee/ia noiiaoieia?/ia aeaaeai?y IIC Oe?a?ie, Iieoaaa, 1999. Aeena?oaoe?th i?enay/aii i?iaeai? i?io?eaeoeee o?no?iiai ea???no coa?a. ?ic?iaeaii iiaee a?o/eciyiee ooi?ai?uoth/ee aa?iaoee “Aeaioaeaen-11O” c iineeaieie i?oeieie oa?aeoa?enoeeaie. Anoaiiaeai? aenie? ?aoaioe?ei? aeanoeaino? cacia/aiiai neeaaeo. I?ney canoinoaaiiy aa?iaoeea “Aeaioaeaen-11O” ciaioo?oueny aaeni?aoe?y i?e?ii?aai?ci?a ia iiaa?oi? ia?iaeaieo coa?a. O ee?i?oe? ioe?iaia aoaeoeai?noue aeei?enoaiiy aa?iaoeea “Aeaioaeaen-11O”, uiaei caa?aaeaiiy oa ?aaeoeoe?? o?no?iiai ea???no. ?ic?iaeaii iiaee niin?a i?io?eaeoeee o?no?iiai ea???no oa aeiaaaeaii eiai aenieo ea???ni?io?eaeoe/io aoaeoeai?noue. Iniiai? ?acoeueoaoe ?iaioe ai?iaaaeaeai? o a?o/eciyia i?iieneiaa ae?iaieoeoai. I?iaaaeai? aeine?aeaeaiiy i?aeoaa?aeaeothoue iaaee/io aoaeoeai?noue a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea "Aeaioaeaen-11O" oa aoaeoeai?noue ? aeioe?euei?noue canoinoaaiiy ?ic?iaeaiiai niiniao i?io?eaeoeee o?no?iiai ea???no. Eeth/ia? neiaa: coae, ea???n, i?io?eaeoeea, aa?iaoee. Aiiioaoeey Iaca?yi ?.N. ?ac?aaioea e iainiiaaiea i?eiaiaiey ioa/anoaaiiiai ooi?niaea?aeauaai aa?iaoeea “Aeaioaeaen-11O” (eaai?aoi?ii-eeeie/aneia enneaaeiaaiea) - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.22 - noiiaoieiaey. - Oe?aeineay iaaeeoeeineay noiiaoieiae/aneay aeaaeaiey IC Oe?aeiu, Iieoaaa, 1999. I?iaeaia oenno?iiai ea?eana iinoiyiiuo coaia naaiaeiy yaeyaony iaeiie ec aaaeoueo i?iaeai aeaoneie ea?eanieiaee. Oe?ieee niaeo? aa?iaoeeia ca?oaaaeiiai i?iecaiaenoaa aeey i?ioeeaeoeee oenno?iiai ea?eana i?aeoe/anee iaaeinooiai aeey ianniaiai eniieueciaaiey a oeieao, aeaoneeo naaeao, iieeeeeieeao ec-ca aunieie noieiinoe. E?iia yoiai ca?oaaaeiua neeaiou i?aaenoaaeytho niaie a iniiaiii aacooi?enoua iaiaiieiaiiua eiiiiceoeee, /oi ia iaania/eaaao iaiaoiaeeiuo i?i/iinoiuo e i?ioeaiea?eiciuo naienoa. A nayce n yoei iiene iiauo aeinooiiuo ioa/anoaaiiuo n?aaenoa i?ioeeaeoeee oenno?iiai ea?eana yaeyaony aeooaeueiie caaea/ae iao/iuo enneaaeiaaiee. A i?ioeanna ?aaiou ?ac?aaioai iiaue ioa/anoaaiiue aa?iaoee-oioiiieeia? “Aeaioaeaen - 11O”, n aunieeie i?i/iinoiuie oa?aeoa?enoeeaie, eioi?ue niaea?aeeo 45% iai?aaie/aneiai aii?aoe?iaaiiai noaeeiiaiieieoaey e 5% ooi?eaea iao?ey. A i?ioeanna eaai?aoi?iuo enneaaeiaaiee auei onoaiiaeaii, /oi ?ac?aaioaiiue iaoa?eae eiaao aeoaeio ioaa?aeaeaiey - 4,2 ± 0,17 ii, iee?ioaa?aeinoue 281,3 ± 11,24 I/ ii2, ?ac?ooathuaa iai?yaeaiea i?e naeaoee - 162,6 ± 8,13 IIa, aiaeiiiaeiuaiea 7,4 ± 0,28 iea/ii3 , eiie/aneoth oi/eo oaeo/anoe - 913,5 ± 40,4 IIa. Aeaiiua iieacaoaee naeaeaoaeuenoaotho i aunieie iaoaie/aneie i?i/iinoe iaoa?eaea e aai niiniaiinoe auaea?aeeaaoue aeaaaoaeueiua iaa?ocee. I?e eco/aiee acaeiiaeaenoaey aa?iaoeea “Aeaioaeaen - 11O” n yiaeueth coaa ia neaie?othuai yeaeo?iiiii iee?ineiia ii?aaeaeaiu aai aunieea ?aoaioeeiiiua aiciiaeiinoe, niiniaiinoue ia?aciauaaoue ieioiue eiioaeo n iiaa?oiinoueth coaa. Yoe aeaiiua auee iiaeoaa?aeaeaiu n iiiiuueth iaoiaea aaoi?aaeeia?aoee. A i?ioeanna iee?iaeieiae/aneiai enneaaeiaaiey onoaiiaeaii aeinoiaa?iia nieaeaiea aeiee Str. mutans ia aeaaaoaeueiie iiaa?oiinoe, eioi?ay ia?aaioaia aa?iaoeeii “Aeaioaeaen - 11O” ii n?aaiaieth n aeaaaoaeueiie iiaa?oiinoueth aei aa?iaoecaoeee e ia?aaioaiiie aac-ooi?enoui neeaioii. A eeeieea ioeaiaii aunieay ea?eani?ioeeaeoe/aneay aooaeoeaiinoue aa?iaoeea “Aeaioaeaen - 11O” e ?ac?aaioaiiiai iiaiai niiniaa i?ioeeaeoeee oenno?iiai ea?eana, eioi?ue i?aaeoniao?eaaao niaianoiia eniieueciaaiea aa?iaoeea “Aeaioaeaen - 11O” e ?aieia?aeece?othueo aeeneia “Ooi?aeeoineaeue”. Ia 500 ia?auo iinoiyiiuo iiey?ao o 250 aeaoae 6-8 eao auee eco/aiu iieacaoaee nio?aiiinoe aa?iaoeea e ?aaeoeoeee oenno?iiai ea?eana. ?aaeoeoeey oenno?iiai ea?eana i?e ioaeaeueiii eniieueciaaiee aa?iaoeea “Aeaioaeaen-11O” ninoaaeea 91%, i?e eniieueciaaiee ?ac?aaioaiiiai niiniaa - 96%. Iniiaiua ?acoeue-oaou ?aaiou aiaae?aiu a ioa/anoaaiiia i?iecaiaenoai. Eeth/aaua neiaa: coau, ea?ean, i?ioeeaeoeea, aa?iaoee. Annotation R. S. Nazaryan. Development and substantiation of application domestic hermetic composition paste which contains fluorine “Dentalex - llF” (laboratory-clinical research) — Manuscript. The dissertation for competition of a scientific degree as the candidate of medical sciences on a specialty 14. 01. 22 - stomatology. - Ukrainian medical dental academy HD of Ukraine. Poltava, 1999. The dissertation is devoted to a problem of prophylaxis of teeth fissure caries. Within this work a new domestic hermetic composition paste “Dentalex - llF”, which contains fluorine has been developed. It has strengthened characteristics of solidity. The high retential properties of the given structure have been ascertained. The adsorption of microorganisms on a surface of the processed teeth is decreased by the use of hermetic composition paste “Dentalex - llF”. The efficiency of use of the given material has been appreciated and tested in clinic on parameters of hermetic composition safety and reduction of fissure caries. The new way of prophylaxis of fissure caries has been developed and it has also showed a high caries-preventive efficiency which has been proved. The basic results of work have found an introduction into Ukrainian industrial manufacture. The medical efficiency of domestic hermetic composition paste “Dentalex-llF” with fluorine has been marked. The efficiency and expediency of use of the developed way of fissure caries prophylaxis has also been marked in the given work. Key words: teeth, caries, prophylaxis, sealant. IACA?ssI ?icaia Noaiai?aia “?ic?iaea oa iaa?oiooaaiiy canoinoaaiiy a?o/eciyiiai ooi?ai?uoth/iai aa?iaoeea “Aeaioaeaen-11O”(eaai?aoi?ii-ee?i?/ia aeine?aeaeaiiy)” Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe A?aeiia?aeaeueiee ca aeione aeioeaio Aieiaei I.A. I?aeienaii aei ae?oeo 8.06.99 ?. Ianya - 1,25 ae?.a. Oi?iao A5 iai?? ionaoiee 80 a/i2 Oe?aae 100 i?ei. Cai. ? 4772 OIA Eo?ni?, Oa?e?a, ia?. Oaao?aeueiee 11/13, e. 53

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