Oe?a?inueea Oa?iaoeaaoe/ia Aeaaeai?y

Aao?ae Ieaia Aiaoie??aia

OAeE 615.451.35:616-001.17:638.135

?ic?iaea oa aeine?aeaeaiiy i?iiiai aa?icieueiiai i?aia?aoo aeey
e?eoaaiiy i?iiaiaaeo o?aaeaiue, oa?i?/i?o oa o?i?/ieo ii?e?a

15.00.01 — oaoiieia?y e?e?a oa i?iieneiaa oa?iaoe?y

A A O I ? A O A ? A O

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa

oa?iaoeaaoe/ieo iaoe

Oa?e?a 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? aioa/ii? oaoiieia?? e?e?a Oe?a?inueei?
oa?iaoeaaoe/ii? aeaaeai??, i?i?noa?noai ioi?iie caei?ia’y Oe?a?ie.

Iaoeiaee ea??aiee: caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,

aeieoi? oa?iaoeaaoe/ieo iaoe,
i?ioani?

OEOIIIA IEAENAIAe? ?AAIIAE*,

Oe?a?inueea oa?iaoeaaoe/ia
aeaaeai?y,

i?i?aeoi? c iaoeiai-aeine?aeii?
?iaioe,

caa?aeoth/ee eaoaae?ith aioa/ii?
oaoiieia?? e?e?a.

Io?oe?ei? iiiiaioe: aeieoi? oa?iaoeaaoe/ieo iaoe, i?ioani?

*O?OIA AEAAeENEAA ?AAIIAE*,

Oe?a?inueea oa?iaoeaaoe/ia
aeaaeai?y,

caa?aeoth/ee eaoaae?ith aioiaeo
e?ea?nueeeo cania?a

eaiaeeaeao oa?iaoeaaoe/ieo iaoe,
annenoaio

EIAA?I IAO?I AIAe??EIAE*,

Caii??aenueeee iaaee/iee
oi?aa?neoao,

eaoaae?a oaoiieia?? e?e?a.

I?ia?aeia onoaiiaa: Aea?aeaaiee iaoeiaee oeaio? e?ea?nueeeo cania?a

i. Oa?e?a, eaai?aoi??y o?i?/ii?
oaoiieia?? e?ea?nueeeo

?a/iaei

Caoeno aeena?oaoe?? a?aeaoaeaoueny “_29_”_aa?aniy_ 1999 ?ieo i “_12_”
aiaeei? ia can?aeaii? niaoe?ae?ciaaiii? a/aii? ?aaee Ae 64.605.01 i?e
Oe?a?inuee?e oa?iaoeaaoe/i?e aeaaeai?? ca aae?anith: 310002, i. Oa?e?a,
aoe. Iooe?inueea, 53.

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Oe?a?inueei?
oa?iaoeaaoe/ii? aeaaeai?? (310168, i. Oa?e?a, aoe. Aethoa?a, 4).

Aaoi?aoa?ao ?ic?neaiee “_27_” _na?iiy_ 1999 ?ieo

A/aiee nae?aoa?

niaoe?ae?ciaaii? A/aii? ?aaee
A?eoeaiei ?. N.

Caaaeueia oa?aeoa?enoeea ?iaioe

AEOOAEUeI?NOUe OAIE OA NOOI?IUe AeINE?AeAEAIIss OAIAOEEE. O no/ani?e
iaaee/ii? i?aeoeoe? aeei?enoiao?oueny a?eueo 30 oen. e?ea?nueeeo
cania?a, a?naiae eio?eo iino?eii c?inoa?. Ii?yae ?c na?oeaai-noaeeiieie
caoai?thaaiiyie, a?aaeaiiyie oeoieiai-eeoeiaiai o?aeoo ? aa?oi?o
aeeoaeueieo oeyo?a ? oaiaeaioe?y aei c?inoaiiy /enea iieieia?/ieo
caoai?thaaiue, a oaeiae aeiaaino?ieiai iacaaieieo ii?e?a, io?eiaieo o
?acoeueoao? iiaooiaeo ? ae?iaie/eo o?aai. Oea ca’ycaii ia?aaaaeii ?c
caa?oaeiaiiyi iaaeieeoiueiai na?aaeiaeua o?i?/ieie ? ?aae?iaeoeaieie
a?aeoiaeaie, ?iaioith a cii? ii e?ea?aeaoe?? aaa??? ia *AAN, ?icaeoeii
aoiiii? aia?aaoeee ? aeei?enoaiiyi aeaea?ae ?ii?coth/eo aei?ii?ithaaiue,
a ia ae?iaieoeoa? e o iiaoo?-?c iaaeio?eiaiiyi oaoi?ee aaciaee i?e
ei?enooaaiiyi onoaoeoaaiiyi, ?aaeoeaaie e aeaeo?ii?eeaaeaie. C eiaeiei
?ieii c?inoa? e?euee?noue oai?eo ?aeiaeie caoai?thaaiiyie. O eiiieaeni?e
oa?ai?? ceiye?nieo iiaiooai?aiue e??i o?i?ioa?ai?? aeei?enoiao?oueny ?
?aae?ioa?ai?y. I?aia?aoe, ui aeei?enoiaothoueny aeey e?eoaaiiy ?
i?io?eaeoeee iino?aae?aoe?eieo aieea?a, a oaeiae aeey e?eoaaiiy ??cieo
ii?e?a, iiaeii? iaoe aaaaoiiai?aaeaio ae?th ? canoiniaoaaoeny
aeeoa?aioe?eiaaii a caeaaeiino? a?ae nooiaiy i?iiaiaai? ii?acee aai
ii?eo.Oeei aeiiaai a?aeiia?aea? oaiieueiee a?ae?ioiaiee i?aia?ao
i?iiie?no.

Ia aeioe?eueii, ye ?ai?o, ieaioaaoe iinoa/aiiy i?aia?ao?a oa
a?ieia?/ii-aeoeaieo noanoaioe?e ?c-ca ei?aeiio, oiio ?ic?iaea ?
ai?iaaaeaeaiiy a iaaee/io i?aeoeeo a?o/eciyieo e?ea?nueeeo cania?a, ui
caaacia/othoue oe?ieee niaeo? oa?aiaaoe/ii? ae?? ia iniia? i?e?iaeieo
niieoe, ? aeooaeueiei iaoeiaei iai?yieii o no/ani?e oa?iaoe??.

C iaeyaeo ia aeuaaeeeaaeaia, aeioe?eueii ?icoe?aiiy iiiaieeaoo?e
cania?a, ui a?aeiia?aeathoue no/aniei aeiiaai aeey e?eoaaiiy ii?e?a ?
i?iiaiaaeo o?aaeaiue oe??e oa neeciaeo iaieii?e.

O inoaii? ?iee aino?i noi?oue ieoaiiy i?i aa?aaei? oa c?o/i? oeyoe
iaianaiiy e?e?a ia o?aaeai? ae?eyiee o?ea. Iaeiei c ia?niaeoeaieo
i?aia?ao?a ? aa?icieueia e?ea?nueea oi?ia.

Aeoiaey/e c aeuaaeacaiiai, ie iinoaaeee iaoith ?ic?iaeo aa?icieueii?
e?ea?nueei? oi?ie c oaiieueiei aeae?ioiaiei i?aia?aoii i?iiie?no (OAII).

CA’ssCIE ?IAIOE C IAOEIAEIE I?IA?AIAIE, IEAIAIE, OAIAIE. Aeena?oaoe?eia
?iaioa aeeiiaia a?aeiia?aeii aei ieai?a iaoeiai-aeine?aeieo ?ia?o Oe?OA
(iiia? aea?ae?a?no?aoe?? 0198O007008 oa i?iaeaiii? eii?n?? “Oa?iaoe?y”
IIC Oe?a?ie).

IAOA ?IAIOE. ?ic?iaea iioeiaeueiiai iaoeiai iaa?oioiaaiiai neeaaeo,
oaoiieia?? oa iaoiaeee eiio?ieth yeino? aa?icieth c OAII aeey e?eoaaiiy
i?iiaiaaeo o?aaeaiue oe??e oa neeciaeo iaieiiie, oa?i?/ieo oa o?i?/ieo
ii?e?a.

CAAeA*? AeINE?AeAEAIIss:

— i?iaiae?coaaoe e ocaaaeueieoe no/ani? aeai? e?oa?aoo?e ii noai?aiith
i?ioei?ii?iaaeo, i?ioeii?eiaeo cania?a aeey i?noeaaiai e?eoaaiiy
i?iiaiaaeo o?aaeaiue oe??e oa neeciaeo iaieiiie, a oaeiae noeioeyoi??a
?aia?aoeaieo i?ioean?a oa iaoai?cio ?o ae??;

— oai?aoe/ii e aenia?eiaioaeueii iaa?oiooaaoe neeaae oa oaoiieia?th
aa?icieth c OAII, ui i?ecia/aiee aeey e?eoaaiiy ii?e?a oa i?ii?iaaeo
ii?acie oe??e ? neeciaeo iaieiiie;

— ?ic?iaeoe eaai?aoi?iee ?aaeaiaio ae?iaieoeoaa aa?icieueiiai
i?aia?aoo;

— i?iaanoe aeine?aeaeaiiy ii anoaiiaeaiith iniiaieo iieaciee?a yeino?
aa?icieth c OAII, iaa?oiooaaoe oiiae caa?aaaiiy ? oa?i?ie aeei?enoaiiy;

— i?iaanoe a?ieia?/i? aeine?aeaeaiiy ?ic?iaeaiiai aa?icieth;

— ?ic?iaeoe ii?iaoeaii-oaoi?/io aeieoiaioaoe?th ia aa?icieue
“I?ioacieue -i?iiee” ? i?aaenoaaeoe ?? o Oa?iaeieia?/iee eii?oao IIC
Oe?a?ie c iaoith io?eiaiiy aeicaieo ia i?iaaaeaiiy ee?i?/ieo
aei?iaoaaiue.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAO?A. Oai?aoe/ii e aenia?eiaioaeueii
iaa?oioiaaiee neeaae oa ?aoe?iiaeueia oaoiieia?y e?ea?nueeiai i?aia?aoo
o oi?i? aa?icieth, ui i?noeoue OAII ? yeee ?aeiiaiaeo?oueny aeey
i?io?eaeoeee oa e?eoaaiiy i?iiaiaaeo o?aaeaiue oe??e, neeciaeo iaieiiie,
oa?i?/ieo, o?i?/ieo ii?e?a ? ia? eiia?iiaaio oa?aiaaoe/io ae?th.

Aea/aii aeanoeaino? ?ic?iaeaiiai aa?icieth, cai?iiiiiaai? iaoiaee
aiae?co yeino?, aecia/ai? oiiae ? /an eiai caa?aaaiiy.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAO?A. ?ic?iaeaii neeaae oa
oaoiieia?th aa?icieth c OAII i?ae oiiaiith iacaith “I?ioacieue-i?iiee”.
Noai?aii oa caoaa?aeaeaii eaai?aoi?iee ?aaeaiaio ae?iaieoeoaa aa?icieth
? aei?iaoaaiee a oiiaao o?i?ei-oa?iaoeaaoe/iiai caaiaeo. Aeiee?i?/ieie
aeine?aeaeaiiyie iieacaia aeniea niaoeeo?/ia aeoeai?noue aa?icieth c
OAII i?e e?eoaaii? i?iiaiaaeo o?aaeaiue oe??e, oa?i?/ieo oa o?i?/ieo
ii?e?a.

?ic?iaeaia ? iiaeaia aei Oa?iaeieia?/iiai eii?oaoo IIC Oe?a?ie
ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia aa?icieue “I?ioacieue-i?iiee”

(eeno OE ? 2204/A a?ae 24.12.97.)

O?aaiaioe ?iaioe ai?iaaaeaeai? a iaa/aeueiee ? ae?iaie/ee i?ioean

?yaeo iaaee/ieo aoc?a Oe?a?ie.

INIAENOEE AIANIE CAeIAOAA*A. I?iaaaeaii aiae?c e?oa?aoo?ieo aeaieo ii
noai?aiith i?ioei?ii?iaaeo, i?ioeii?eiaeo cania?a. Iaa?oioiaaii oa
?ic?iaeaiee neeaae ? oaoiieia?y iiai? e?ea?nueei? oi?ie ia iniia? OAII —
aa?icieth i?ae oiiaiith iacaith “I?ioacieue-i?iiee”. ?ic?iaeaii
iaoiaeeee eiio?ieth yeino? aa?icieth “I?ioacieue-i?iiee”, ui aa?eoee a
i?iaeo OON, ?ic?iaeaiee oa caoaa?aeaeaiee eaai?aoi?iee ?aaeaiaio ia
ae?iaieoeoai aa?icieth c OAII.

AI?IAAOe?ss ?ACOEUeOAO?A AeENA?OAOe??. Iniiai? iieiaeaiiy
aeena?oaoe?eii? ?iaioe aeeeaaeai? ia i?aeia?iaeieo oa ?anioae?eainueeeo
iaoeiai-i?aeoe/ieo eiioa?aioe?yo: “Ea?oaaiiy ioi?iie caei?ia’y IAN
Oe?a?ie ii oaeineiiaethaaiith noiiaoieia?/ii? aeiiiiiae” (Oa?e?a, 1996),

“Oai??y ? i?aeoeea noai?aiiy e?ea?nueeeo i?aia?ao?a”, i?enay/aia
75-??//th c aeiy ia?iaeaeaiiy ?aeoi?a OO?, ae.oa?iaoe. iaoe, i?ioani?a
Naea Ae.I. (Oe?OA, Oa?e?a,1998), a oaeiae ia iaoeiaeo nai?ia?ao
“Aeooaeuei? i?iaeaie no/anii? oaoiieia?? e?e?a” (Oa?e?a, 1998 — 1999).

IOAE?EAOe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 7 ?ia?o o oaoiaeo
aeo?iaeao, o oiio /ene? 7 noaooae.

IANssA ? NO?OEOO?A AeENA?OAOe??. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 135
noi??ieao ? ia?aaoaa? c anooio, iaeyaeo e?oa?aoo?e, /ioe?ueio aeaa
aenia?eiaioaeueieo aeine?aeaeaiue, aeniiaeia, nieneo aeei?enoaieo
aeaea?ae, aeiaeaoe?a. ?iaioa ?ethno?iaaia 14 oaaeeoeyie, i?noeoue 12
iaethie?a. Nienie aeei?enoaieo aeaea?ae i?noeoue 149 aeaea?ae, o oiio
/ene? 30 ?iicaiieo.

Iniiaiee ci?no ?iaioe

O i?ioean? ?ic?iaee aa?icieth “I?ioacieue-i?iiee” iaie aoa aeei?enoaiee
oaiieueiee a?ae?ioiaiee i?aia?ao i?iiie?no (OAII — ON 42O-34-20-95), a
oaeiae i?aia?ao IN-20 (AeANO 10730-82),oaei-80 (ON 42-2540-88),
noaa?ien-6 (AeANO 8980-75), aeieniiie?ia?e, nie?oe neioaoe/i? aee?i?
ia?aeiieo o?aeoe?e N16-N21 (AeANO 23783-79), nie?o aoeeiaee
?aeoeo?eiaaiee (AeANO 5982-67), aiaea i/euaia (ON 42-2619-89), oeaaeii
12 (AeANO 19212-73).

I?e aea/aii? aeanoeainoae aa?icieth, ui ?ic?iaeyany aeei?enoai?
caaaeueiii?eeiyo? iaoiaee i?aaiieaioe/ieo, oaoiieia?/ieo,
o?ceei-o?i?/ieo, i?e?ia?ieia?/ieo ? a?ieia?/ieo aeine?aeaeaiue, ui
aeicaieythoue ia’?eoeaii ioe?ithaaoe ye?ni? oa?aeoa?enoeee i?aia?aoo ia
i?aenoaa? io?eiaieo aenia?eiaioaeueieo ?acoeueoao?a.

?ic?iaea neeaaeo oa oaoiieia?? aa?icieth c oaiieueiei a?ae?ioiaiei
i?aia?aoii i?iiie?no.

Caaaeath/e ia oa, ui oaiieueiee a?ae?ioiaiee i?aia?ao i?iiie?no (OAII)
ia ?ic/eiee o aiae?, aeine?aeaeaiiy i?iaiaeeee o aeaeyae? eiai nie?oiaeo
?ic/ei?a. Aeey noai?aiiy aa?icieueii? nenoaie aoee aea/ai? ?yae
iiaa?oiaai-aeoeaieo ?a/iaei (IA?) o aeaeyae? aiaeyieo ?ic/ei?a. Iaie
aoee ia?ai? IA?, ye? aeiiiiiaathoue noai?eoe iioeiaeueio oaoiieia?th
i?aia?aoo, ca?eueoeoe oaeaee?noue aea?eueiaiiy aeoeaieo ?a/iaei ?c
e?ea?nueei? oi?ie ? aeinyaoe aenieiai oa?aiaaoe/iiai aoaeoo, a oaeiae
cieceoe iia?/io ae?th.

Iaea?eueoa ia?niaeoeaiith e?ea?nueeith oi?iith aeey e?eoaaiiy ii?e?a ?
i?iiaiaaeo o?aaeaiue oe??e ? neeciaeo ? i?iiooai?thth/? aa?icieuei?
i?aia?aoe.

I?e ?ic?iaoe? neeaaeo aa?icieth c OAII aoa i?iaaaeaiee ?yae
aeine?aeaeaiue aiaeieo ?ic/ei?a ia?iiiaaieo IA? (nietha?e?caoi??a oa
i?iiooai?thaa/?a) ? aeieniiie?ia??a. Aaaeeeaei e??oa???i IA? ? ?o
a?ae?io?eueii – e?iio?eueiee aaeain (AEA). Ii ?ici??o
a?ae?io?eueii-e?iio?eueiiai aaeaino iiaeia aecia/eoe eiie?aoio iaeanoue
canoinoaaiiy IA?. Aaee/eia iiaa?oiaaiai iaoyao (( ), aecia/aia iaoiaeii
I.A. ?aa?iaea?a, a?eueoino? aeine?aeaeoaaieo IIA? ciaoiaeeoueny a
?ioa?aae? 39 — 50 iI/i (oaae. 1 ). Iaeiae, c? ca?eueoaiiyi ai?noo
a?ae?ioiaii? /anoeie a iieaeoe? aeieniiie?ia?a i?e iaeiaeia?e
iieaeoey?i?e ian? aae?/eie e?eoe/ieo eiioeaio?aoe?e ieoeaeiooai?aiiy
(EEI) ciaioothoueny. IA?, ui iathoue iecuee? cia/aiiy EEI, iiaeooue aooe
aeei?enoai? a oaoiieia?? a iaaaeeeeo eiioeaio?aoe?yo.

Iaeiae, /eneai? aioeueaaoi?e, cieaeoth/e iiaa?oiaaee iaoya, ia ooai?youe
caoenio ie?aeo iaiao?aeii? iaoai?/ii? i?oeiino?, ui iaaeaaaea a nenoai?
no?eeino? oa ia?aoeiaeaeaea a eiaeanoeaioe?? aeenia?a?eiaaieo /anoie.
Iaie aeey ?ic?iaee i?iiiai aa?icieueiiai i?aia?aoo a yeino?
i?iiooai?thaa/a ia?ai? IN-20 ? i?ienaiie – 268 (I-268). C iaoith
noaa?e?caoe?? eiei?aeii? aeenia?n?? i?iiooai?thaa/?a ? noai?aiiy
iaiao?aeieo a(yceiieanoe/ieo aeanoeainoae, o oaoiieia?/ieo ?ic?iaeao
aeei?enoai? nie?oe neioaoe/i? aee?i? ia?aeiieo o?aeoe?e N16-N21.

?aieia?/i? aeanoeaino? ?ic/ei?a aeieniiie?ia??a iaie aea/ai? ia i?eeaae?
“?aioano -2” oa ?ai-a?neic?iao?? ii Aaiea?o a ae?aiacii? eiioeaio?aoe?e
a?ae 0 aei 50 % ? i?e oaiia?aoo?? a?ae 5 aei 80 0N. ?acoeueoaoe
iieacaee, ui a’yce?noue ?ic/ei?a aei 40 % aeniiiaioe?aeueii caeaaeeoue
a?ae eiioeaio?aoe??, a ii/eiath/e c 45 % a?aeaoaa?oueny aaeaiooai?aiiy ?
i?iaeoeoe, ui ooai?youeny, iathoue ae?aaeai? o?enio?iii? aeanoeaino?.
?acoeueoaoe iieacai? ia ?en. 1

Aea/aeeny oaeiae ?aieiae/i? aeanoeaino? ?yaeo aa?icieueieo eiioeaio?ao?a
oa i?i, ?c aeiaeaaaiiyi i?iiaeaioa a e?eueeino? 20%. ?acoeueoaoe aei??o
na?ae/aoue, ui ca?eueoaiiy eiioeaio?aoe?? noaa?e?caoi?a (nie?o?a
o?aeoe?? N16-N21) o ?ic/eiao eiioeaio?ao?a oyaia ca niaith c?inoaiiy
nooiaiy o?enio?iiiino? oa a’yceino?.

Ia?aiao?e, ui a?aeiia?aeathoue ca ye?noue aa?icieueieo i?aia?ao?a o
caeaaeiino? a?ae ai?noo i?iiaeaioo, aecia/aee ca iaoiaeeeaie caaaeueii?
noaoo? “Aa?icie?” AeO OI, a oaeiae ii aeiaeaoeiaei iieacieeai. Cii/oth/o
caeaoi?noue aecia/aee ii oaeaeeino? i?ini/oaaiiy o?eueo?oaaeueiiai
iaia?o, ieiuath 7,5 ni2. Aonoeio i?i aecia/aee caaaeoaaiiyi. Aecia/aiiy
oa?i?io aeeooy i?i i?iaiaeeee oeyoii aei?ene?aaiiy aecia/aii? e?eueeino?
i?ie c aaeiia ia i?e?in?oeo oa a?aecia/aee /an iiaiiai iiaaeaiiy
no?oeoo?e i?ie. Oei aeaea/? oa ciai?oi?e aeaeyae i?i aecia/aee
a?coaeueii.

Aeai? aea/aiiy ye?nieo oa?aeoa?enoee aa?icieueieo i?i i?eaaaeai? a
oaae. 2, ?c yei? aeieeaa?, ui iaea?eueoa iioeiaeueiee ai?no i?iiaeaioo a
i?aia?ao?, yeee ?ic?iaeth?oueny- 5,0 .

Aioei?e?iaio aeoeai?noue nie?oiaeo ?ic/ei?a OAII, ie?aieo eiiiiiaio?a
aea/aee caaaeueiii?eeiyoei o i?e?ia?ieia?/i?e i?aeoeoe? iaoiaeii
aaa?iaeo ieano?aie. O yeino? oano-ooai?a aeei?enoiaoaaee eoeueoo?e,
io?eiai? c iocath eoeueoo? Ae?NE ?i. E. A. Oa?anaae/a:

S. aureus ATCC 25923, Str. pneumonieae 4/49, B. subtilis ATCC 6633, E.
coli ATCC 25922, Sal. typhymarium ee.14, Pseud. aeruginosa ATCC 9027,
ATCC 27853, C. albicans ATCC 885-653. Aeine?aeaeaiiy aeeiioaaeeny a
i’youeio iiaoi?iinoyo noiniaii eiaeiiai ooaio.

?ai?oa anoaiiaeaii, ui nie?oia? ?ic/eie OAII aeyaeythoue aenieee
??aaiue aaeoa?eoeeaeii? ae?? noiniaii on?o aeei?enoiaoaaieo eoeueoo?. Ia
i?aenoaa? oa?iaeieia?/ieo ? i?e?ia?ieia?/ieo aeine?aeaeaiue iaie aoea
ia?aia eiioeaio?aoe?y OAII, ui aei??aith?oueny 1,0 %.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue aoee ia?ai? e iaa?oioiaaiee
neeaae ? oaoiieia?y i?iiiai aa?icieueiiai i?aia?aoo c OAII i?ae oiiaiith
iacaith “I?ioacieue — i?iiee” (oaa. 3).

Oaaeeoey 1 — O?ceei-o?i?/i? aeanoeaino? aeieni?aiie?ia??a oa ?yaeo IIA?

Iaeiaioaaiiy Iiia? OO I. i. (ii OO) Neeaae (ii OO) s, iI/i

(1% ?ic/ei) EEI, % AEA

I?ienaiie 268 6-14-14-80 13 000 n = 26

m = 44-45 46,8 0,009 26,7

I?ienaiie 224 6-14-642-82 700 n = 34

m = 38 49,2 0,009 21,1

I?ienaiie 186 38-192160-84 4500 — 50,3 0,078 21,11

I?ienaiie OeE-3 6-14-268-80 3670 — 40,2 0,156 19,4

A?ae?iiie 200 6-14-41-77 — n = 182

m = 34 48,0 0,312 26,7

AAeIA-067 38-407320-85 2000 — 45,5 0,120 15,4

AAeIA-107 38-407210-82 3500 — 40,3 0,083 14,9

AAeIA-108 38-707219-82 5500 — 48,7 0,127 15,3

Iieienaia? 188 6-14-271-82 8350 n = 150

Oaoiieia?y i?noeoue o nia? an? iniiai? noaae?? iaea?aeaiiy aa?icieueieo
nenoai : aiooaaiiy aiaeyii? ? nie?oiai? oace, aiiiaai?caoeey
eiioeaio?aoo, a oaeiae aeicoaaiiy eiioeaio?aoo, caiiaiaiiy aaeii?a
i?iiaeaioii, eiio?ieue yeino?, oiaeiaeo ? ia?e??oaaiiy. C iaoith
iioei?caoe?? oaoiieia?? aa?icieth iaa?oioiaaiee oaiia?aoo?iee ?aaeei
aiooaaiiy, ii?yaeie aaaaeaiiy eiiiiiaio?a, oi/i?noue aeicoaaiiy
i?iiaeaioii. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?ic?iaeaiee
eaai?aoi?iee ?aaeaiaio ae?iaieoeoaa aa?icieth.

Noai?aia iaie oaoiieia?/ia noaia ae?iaieoeoaa i?iiiai i?aia?aoo c OAII a
aa?icieuei?e oiaeiaoe?, ui aa?eaea a i?iieneiaee ?aaeaiaio, iiaeaia ia
?en.2 oa ai?iaiaaia a caaiaenueeeo oiiaao ia a?aee?eoiio aeoe?iia?iiio
oiaa?enoa? (AAO) “Noiia” (i. Oa?e?a).

Aea/aiiy aeanoeainoae ? ?ic?iaea iaoiaeee aiae?co aa?icieth “I?ioacieue
— i?iiee”

C iaoith ioe?iee oa eiio?ieth yeino? ?ic?iaeaiiai aa?icieth, iaie
aea/ai? i?aaiieaioe/i? (ciai?oi?e aeaeyae, eie??, caiao) oa
o?ceei-o?i?/i? iieacieee. I?ia, io?eiaia c ??cieo na??e aa?icieth
“I?ioacieue — i?iiee” yaey? niaith iaeii??aeio iano a?eiai eieuei?o c
aeiaoei a?aeo?ieii, ?c niaoeeo?/iei caiaoii. Aeine?aeaeaiiy
noaa?eueiino? i?aia?aoo iieacaee, ui a?i ? eiei?aeii oa
oa?iinoaa?eueiei, ia? i?oei?noue oa aa?iaoe/i?noue oiaeiaee, a oaeiae
iaaiee a?aenioie nii?iaeiaiiy aa?icieueiiai aaeiio ? a?aeiia?aeio ?iaioo
eeaiaiiai i?eno?ith – ana oea a?aeiia?aea? aeiiaai AeO OI aeaeaiiy.

Oaaeeoey 3 — Neeaae aa?icieth “I?ioacieue-i?iiee”

Neeaae aa?icieth I?ecia/aiiy ?a/iaei, ui aoiaeyoue aei neeaaeo i?aia?aoo
?a/iaeie, ui caaania/othoue aoaeo

I?iioo-

ai?aiiy Eiina?-aoaaiiy Noaaeeue-iino?

OAII Caaania/o? i?ioecaiaeueio, aioei?e?iaio, aianoacoth/o, ?aia?aoeaio
ae?th

+

Nie?o ao?eiaee ?ic/eiiee, aioei?e?iaiee aaaio — + —

I?ienaiie 268 (aai

IN-20 ) IIA?, aioeueaaoi? 1 ?iaeo, i?iiooai?thaa/ + — —

Nie?oe o?aeoe??

N16-N21 Aioeueaaoi? 2 ?iaeo, noaa?e?caoi? — — +

Aiaea i/euaia ?ic/eiiee + — —

Oeaaeii 12 I?iiaeaio + — +

Aea/aiiy aioei?e?iaieo aeanoeainoae aa?icieth i?iaaaeaii iaoiaeii
aaa?iaeo ieano?aie ia eaoaae?? i?e?ia?ieia?? Oe?OA ca iaoiaeeeith AeO OI
i?ae ea??aieoeoaii eaiae.. oa?iaoe. iaoe Neea?aie E.O. Aeine?aeaeaiiy
iieacaee, ui i?aia?ao aeyaey? iaea?eueoo Oaaeeoey 2 — Iniiai?
aeanoeaino? i?i o caeaaeiino? a?ae e?eueeino? i?iiaeaioo

Eiioeaio?aoe?y

oeaaeiio 12 A’yce?noue, (,

IIa(n Cii/oaaeueia caeaoi?noue, n Oa?i?i aeeooy, oa. (,

ea/i3(10-3 o, % Oei

Aeaea/? Ciai?oi?e aeaeyae

1,0 54,73(2,61 10,0(1,0 0,13(0,01 0,97119

(0,00001 14,30(0,80 A’yeee I?eei/a?oieiaa, oaeaeei ?oeio?oueny

2,0 77,07(3,50 12,0(2,1 0,18(0,01 0,55390

(0,00002 15,74(0,75 A’yeee -,,-

3,0 149,67(2,64 30,0(1,5 0,66(0,02 0,53749

(0,00003 82,25(0,75 A’yeee I?eei/a?oieiaa c aeeneo/ith iiaa?oiath

4,0 167,55(5,01 50,0(1,6 95,0(1,1 0,52518

(0,00001 81,40(0,80 Ieaaiee -,,-

5,0 299,35(8,10 70,0(1,3 300,0(2,3 0,48415

(0,00002 91,00(0,95 Ieaaiee I?eei/a?oieiaa, e?aiiiiae?aia, c aeaaeeith
aeeneo/ith iiaa?oiath

6,0 335,10(6,91 74,0(2,0 330,0(1,6 0,40209

(0,00003 89,54(0,80 Neaaei-??ceee -,,-

7,0 240,15(4,52 120,0(5,2 340,0(2,2 0,25849

(0,00002 82,07(0,80 ??ceee I?eei/a?oieiaa, c aeaaeeith aeeneo/ith
iiaa?oiath

8,0 217,81(6,98 140,0(3,1 340,0(3,2 0,24617

(0,00004 81,40(0,90 ??ceee E?oiii/a?oieiaa, c aeaaeeith iiaa?oiath

9,0 134,04(9,98 160,0(5,7 740,0(4,1 0,24617

(0,00002 70,11(0,70 ??ceee -,,-

10,0 94,94(6,41 200,0(4,3 740,0(4,2 0,27900

(0,00001 86,83(0,80 O?eaenoee -,,-

11,0 83,77(5,75 210,0(2,2 750,0(3,1 0,32824

(0,00003 83,90(0,90 O?eaenoee -,,-

12,0 83,77(6,05 129,0(1,1 750,0(3,2 0,32846

(0,00004 82,30(0,85 O?eaenoee c iio??neoaaiiyi -,,-

15,0 80,54(8,03 127,0(2,5 760,0(4,1 0,33550

(0,00001 80,30(0,60 O?eaenoee -,,-

20,0 76,63(4,51 125,0(4,0 760,0(4,2 0,34688

(0,00002 80,15(0,70 -,,- -,,-

25,0 73,58(6,21 55,0(2,1 760,0(4,2 0,35685

(0,00001 76,12(0,75 -,,- -,,-

30,0 70,0(4,82 20,0(1,5 770,0(5,0 0,40285

(0,00002 70,75(0,90 -,,- -,,-

I?ei?oea: n=5

aioei?e?iaio aeoeai?noue o a?aeiioaii? eieiai? ? iaee/eiai? i?e?ioei?e.
Eiio?ieai neoaeea nie?o aoeeiaee 95%.

Aeey ?aeaioeo?eaoe?? oaiieueieo niieoe a aa?icie? “I?ioacieue — i?iiee”
cai?iiiiiaai? iaoiaeeee ye?nieo ?aaeoe?e, ui i?aeoaa?aeaeothoue
iayai?noue oaiieueiiai a?ae?ieneea (?aaeoe?y c? nie?oiaei ?ic/eiii
cae?ca ieeniiai oei?eaeo — ao?i-caeaia caaa?aeaiiy) oa oeaaiii?ae?a
(oe?aieae?iiaa i?iaa — i?aiaeaai-/a?aiia caaa?aeaiiy).

O ?ic?aooieao e?euee?niiai aecia/aiiy noie oaiieueieo niieoe
aeei?enoiaoaaee eiao?oe??io i?iii?oe?eiino? i?ae iioe/iith aonoeiith (D)
?ic/eio oa eiioeaio?aoe??th noie oaiieueieo niieoe i?e aeiaaeei? oaee?
290 ii. I?e ?ic?iaoe? iaoiaeeee e?euee?niiai aecia/aiiy noie oaiieueieo
niieoe a aa?icie? “I?ioacieue-i?iiee” aeine?aeaeoaaee iiaiee OO niaeo?
iiaeeiaiiy 1% nie?oiaiai ?ic/eio OAII, 2 % aiaeyieo ?ic/ei?a
aeiiii?aeieo ?a/iaei (IN-20, I-268), eiioeaio?aoo aa?icieth ? i?iiiai
i?aia?aoo ia niaeo?ioioiiao?? Specord M — 40 o ethaao? c oiaueiith oa?o
1 ni (a ?ioa?aae? aeiaaeeie oaee? a?ae 210 aei 390 ii). ?ic/eiii
ii??aiyiiy aeey OAII, eiioeaio?aoo e aa?icieth neoaeea nie?o aoeeiaee 95
% eiioeaio?aoe??, a aeey aeiiii?aeieo ?a/iaei aiaea i/euaia. sse aeaeii
c ?en. 3, a iaeano? aeiaaeeie oaee? ( = 290 ii, ui a?aeiia?aea?
iaeneioio iiaeeiaiiy OAII, aeiaeia c aeiiii?aeieo ?a/iaei ia ia?
iaeneioio iiaeeiaiiy, oiaoi ia caaaaeathoue aecia/aiith oaiieueieo
niieoe OAII a aa?icieueiiio i?aia?ao?.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?ic?iaeaiee i?iaeo OON ia
aa?icieue “I?ioacieue — i?iiee”, ui ?aaeaiaioo? eiai ye?noue. Iaeiei ?c
aaaeeeaeo e?eoa???a yeino? aa?icieueieo e?ea?nueeeo oi?i ?
noaa?euei?noue ?o o i?ioean? caa?aaaiiy.

Aeey aeine?aeaeaiiy noaa?eueiino? i?aia?aoo a i?ioean? caa?aaaiiy aoee
i?iaaaeai? ye?ni? ?aaeoe?? ia oaiieuei? niieoee oa oeaaiii?aee,
o?iiaoia?ao?y oa i?e?ia?ieia?/ia /enoioa. O?iiaoia?ao?y iieacaea, ui
iniiai? niieoee oaiieueiiai a?ae?ioiaiiai i?aia?aoo i?iiie?no i?enooi? a
aa?icieth “I?ioacieue — i?iiee”, ui caa??aaany aeaa ?iee.

Aenia?eiaioaeuei? aeai?, i?eaaaeai? a oaae. 4, iieacaee, ui aa?icieue
noaa?eueiee i?ioyaii 2-o ?ie?a caa?aaeaiiy eiai a oiiaao oieiaeeeueieea
oa i?e e?iiaoi?e oaiia?aoo??. E?euee?niee ai?no noie oaiieueieo niieoe
ciaoiaeeoueny a iaaeao ii?ie. Ii nooiai? i?e?iaii? eiioai?iaoe??,
aa?icieue a?aeiia?aea? aeiiaai AeO XI aeey i?aia?ao?a, canoiniaoaaieo
ciai?oii. Oea aeicaieeei ?aeiiaiaeoaaoe oiiae caa?aaeaiiy i?aia?aoo — o
caoeuaiiio a?ae na?oea i?noe? i?e e?iiaoi?e oaiia?aoo??.

Aea/aiiy a?ieia?/ieo aeanoeainoae aa?icieth

“ I?ioacieue — i?iiee”.

Aenia?eiaioaeueiith ioe?ieith a?ieia?/ieo aeanoeainoae aa?icieth
“I?ioacieue – i?iiee” ia eaai?aoi?ieo oaa?eiao i?e aeine?aeaeaii?
aino?i? ? o?ii?/ii? oiene/iino?, aea?a?coth/i? ae?? aa?icieth
anoaiiaeaii, ui i?aia?ao ? a?aeiinii iaoe?aeeeaei.

Niaoeeo?/ia aeoeai?noue “I?ioaciey — i?iiiai” ioe?ithaaeany ia iiaeae?
eieaeueii? i?iiaiaai? ii?acee a iaoethe?a, e?ieee?a oa ii?nueeeo naeiie.
Io?eiai? aeai? na?ae/aoue i?i oa, ui ?aia?aoeaia oa ?aiicaaeeaethth/a
ae?y aa?icieth aeua, /ei o i?aia?aoo, yeee canoiniaothoueny i?e aeai?e
iaoieia?? (iaeai?oiai? ie?? oa i?aia?ao?a ia ?? iniia?).

Oaaeeoey 4 — ?acoeueoaoe aea/aiiy noaa?eueiino? i?aia?aoo
“I?ioacieue-i?iiee” o i?ioean? caa??aaiiy

Oa?i?i caa??aaiiy oa oaiia?aoo?iee ?aaeei

Iaeiaioaaiiy iieaciee?a 18(2 i N 4±2 (N

Ii/aoie 6

i?n. 1

??e 1,5 ?iee 2 ?iee Ii/aoie 6

i?n. 1

??e 1,5 ?iee 2 ?iee

Ciai?oi?e aeaeyae i?ia a?eiai eieuei?o c aeiaoei a?aeo?ieii

?aaeoe?y oioiaeiino? c 5% ?ic/eiii cae?ca ie?niiai oei??aeo

+

+

+

+

+

+

+

+

+

+

?aaeoe?y oioiaeiino? c ii?ioeii iaai?th oa eeneioith
oei?enoiaiaeiaaith eiioe.

+

+

+

+

+

+

+

+

+

+

Ai?no noie oaiieueieo niieoe, % (a?ae 0,1 aei 0,3 % )

0,13

(0,01

0,11

(0,01

0,23

(0,07

0,12

0,02

0,21

(0,03

0,23

(0,05

0,21

(0,02

0,26

(0,04

0,19

(0,02

0,20

(0,07

?iaioa eeaiaiiai iaeaaeiaiiy + + + + + + + + + +

Ia?aa??ea aaeii?a ia i?oei?noue oa aa?iaoe/i?noue + + + + + + + + + +

A?aenioie nii?iaeiaiiy aa?icieueiiai aaeiio, % 91,00

(0,95 92,00

(0,90 91,00

(0,85 91,00

(0,70 92,00

(0,80 91,00

(0,90 92,00

(0,75 91,00

(0,80 92,00

(0,95 91,00

(0,60

I?e?iaia caa?oaeiai?noue:

Aaeoa??e

A?ea?a

Ia a?eueo 10

Ia a?eueo 10

Ia a?eueo 10

Ia a?eueo 10

I?ei?oea:n=5

AENIIAEE

Oai?aoe/ii iaa?oioiaai? oa aenia?eiaioaeueii ?ic?iaeai? iioeiaeuei?
neeaaee ? oaoiieia?y i?iiiai aa?icieueiiai i?aia?aoo “I?ioacieue —
i?iiee”, cai?iiiiiaaiiai aeey i?io?eaeoeee ? e?eoaaiiy i?ii?iaaeo
ii?acie oe??e oa neeciaeo, e?eoaaiiy o?i?/ieo ? oa?i?/ieo ii?e?a.

Aenia?eiaioaeueii aeiaaaeaiee aieea oaoiieia?? aa?icieth ia eiai
noaa?euei?noue ? aeanoeaino? i?e oaeeo ia?aiao?ao, ye aecia/aiee
oaiia?aoo?iee ?aaeei, ii?yaeie aaaaeaiiy ?ia?aae?aioia, a oaeiae ?aaeeie
ia?ai?ooaaiiy oa aeeiai?ee ioieiaeaeaiiy.

Aea/aia aioei?e?iaia aeoeai?noue i?aia?aoo oa nie?oiaeo ?ic/ei?a OAII.
Iieacaii, ui i?aia?ao aeyaey? iaea?eueoo aeoeai?noue o a?aeiioaii?
eieiai? oa iaee/eiai? i?e?ioei?e.

Ii ?ic?iaeaieo iaoiaeeeao ye?niiai ? e?euee?niiai aiae?co ae?th/i?
?a/iaeie — oaiieueiiai a?ae?ioiaiiai i?aia?aoo i?iiie?no aea/ai?
o?ceei-o?i?/i? oa i?aaiieaioe/i? iieacieee a aa?icieueii? e?ea?nuee?e
oi?i?. Aenia?eiaioaeueii aeiaaaeaia noaa?euei?noue i?aia?aoo i?ioyaii
oa?i?ia i?eaeaoiino? (2 ?iee) o cacia/aiiio oaiia?aoo?iiio ?aaeei? (18(2
0 N e 4(2 0 N).

Ia i?aenoaa? oaoiieia?/ieo, o?ceei-o?i?/ieo, oa?iaeieia?/ieo aeine?ae?a
aeiaaaeaii, ui iioeiaeueieie ? ianooii? neeaaee aa?icieth
“I?ioacieue-i?iiee”, a: oaiieueiiai a?ae?ioiaiiai i?aia?aoo i?iiie?no
0,25; nie?oo aoeeiaiai 95% 2,5; i?aia?aoo IN-20 0,625 (aai i?ienaiieo
268 4,0); nie?o?a neioaoe/ieo aee?ieo ia?aeiieo o?aeoe?e N16-N21
0,625; aiaee i/euaiii? 21,0 (aai 17,625); oeaaeiio 12 5,0.

A?ieia?/ieie aeine?aeaeaiiyie i?aia?aoo aeyaeaiee i?ioei?ii?iaaee aoaeo.
Iaoe?aeeea?noue aa?icieth i?aeoaa?aeaeaia ?acoeueoaoaie aea/aiiy
aino?i?, o?ii?/ii? oiene/iino?, a oaeiae aea?a?coth/i? oa
i?noeaaiiiae??cithth/i? ae??.

?ic?iaeaii oa iiaeaia o Oa?iaeieia?/iee eii?oao IIC Oe?a?ie
ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia aa?icieue “I?ioacieue — i?iiee” ?c
iaoith io?eiaiiy aeicaieo ia i?iaaaeaiiy ee?i?/ieo ?nieo?a (eeno OE ?
2204/A a?ae 24.12.1997 )

O?aaiaioe ?iaioe ai?iaaaeaeai? a iaa/aeueiee i?ioean ?yaeo iaaee/ieo
aoc?a Oe?a?ie.

Oaia aeena?oaoe?? a?aeia?aaeaia a ioae?eaoe?yo:

I?ienaiieu — aniiiiaaoaeueiua aauanoaa a oaoiieiaee eaea?noaaiiuo oi?i/
A.N. Aaoo?a, I.A. Eyioiia, A.A. Aaoo?a, A.I. Aacoaeay, A.E. Oeoiiia,
A.A. Naiaiiaa, A.A. ss?ai/oe// Oa?iaeii — 1994. — ? 8/9. –

N.8-14.

E i?iaeaia nicaeaiey iiauo eaea?noaaiiuo oi?i. Niiauaiea 1./ A.N.
Aaoo?a, A.E. Oeoiiia, A.A. Aaoo?a, A.A. Naiaiiaa, A.A. ss?ai/oe, A.Ae.
*a?aaeie/aiei// Oa?iaeii. — 1995. — ? 1/2. — N.9-21

E i?iaeaia nicaeaiey iiauo eaea?noaaiiuo oi?i. Niiauaiea 2. Oaiaeaioeey
?ac?aaioee iaeioi?uo eaea?noa n eiio?iee?oaiui aunaiaiaeaeaieai e
oeaeaiai?aaeaiiie aeinoaaeie/ A.N. Aaoo?a, A.E.Oeoiiia, A.A. Aaoo?a,
A.A. Naiaiiaa, A.E. Iiooei, A.Ae. *a?aaeie/aiei, A.A. ss?ai/oe//
Oa?iaeii. — 1995. — ? 5/6. — N. 15-19

Ieneyoeee?iaaiiua aeeeeoaiieu — ia?niaeoeaiua aniiiiaaoaeueiua aauanoaa
aeey nicaeaiey aioiauo eaea?noaaiiuo oi?i/ A.N. Aaoo?a, A.E. Oeoiiia,
A.A. Aaoo?a, A.E. Iiooei, A.Ae. *a?aaeie/aiei, A.A. ss?ai/oe, A.A.
Aao?ae// Oa?iaeii. -1996. -? 3. -N. 23-30.

?ic?iaea e?ea?nueeiai i?aia?aoo ia iniia? oaiieueiiai a?ae?ioiaiiai
i?aia?aoo i?iiie?no aeey e?eoaaiiy i?ii?iaaeo o?aaeaiue, o?i?/ieo oa
oa?i?/ieo ii?e?a/ I. ?. Oeoiiia, A. N. Aaoo?a, A. A. Aa?aaie, I. A.
Aao?ae, ?. ?. Eiiiaia?oeue// A?niee oa?iaoe??. – 1998. — ? 2 (18). – N.
34-38

Oeoiiiaa N. A., Aao?ae A. A. Oeceei-oeie/aneea enneaaeiaaiey ay?iciey n
oaiieueiui aeae?ioiaiui i?aia?aoii i?iiieena aeey ea/aiey eo/aauo
ii?aaeaiee, oeie/aneeo e oa?ie/aneeo iaeiaia// I?iaeci?. – 1999. — ?6. –

N. 42-43

Oeoiiia A. E., Aao?ae A. A., Aea?eiaaeaaaeue E. A. Yenia?eiaioaeueiia
eco/aiea ?aaeeicaueoiuo naienoa i?aia?aoa n oaiieueiui aeae?ioiaiui
i?aia?aoii i?iiieena “I?ioacieue — iaiiue”// I?iaeci?. – 1999. — ?7. –

N. 45-46.

Aao?ae A. A. ?ac?aaioea e enneaaeiaaiey iaiiiai ay?icieueiiai i?aia?aoa
aeey ea/aiey eo/aauo ii?aaeaiee, oa?ie/aneeo e oeie/aneeo iaeiaia. –
?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa oa?iaoeaaoe/aneeo
iaoe ii niaoeeaeueiinoe 15.00.01. – oaoiieiaey eaea?noa e i?iiuoeaiiay
oa?iaoeey. – Oe?aeineay oa?iaoeaaoe/aneay aeaaeaiey, Oa?ueeia, 1999.

Oai?aoe/anee e yenia?eiaioaeueii iainiiaaia iaiaoiaeeiinoue nicaeaiey
i?aia?aoa a oi?ia ay?iciey aeey ea/aiey e i?ioeeaeoeee eo/aauo
ii?aaeaiee eiaee e neecenouo, a oaeaea iaeiaia ia iniiaa
aeieiae/anee-aeoeaiie noanoaioeee – oaiieueiiai aeae?ioiaiiai i?aia?aoa
i?iiieena (OAII).

?ac?aaioai e enneaaeiaai ninoaa iaiiiai ay?icieueiiai i?aia?aoa
“I?ioacieue — iaiiue” aeey ea/aiey eo/aauo ii?aaeaiee, oa?ie/aneeo e
oeie/aneeo iaeiaia.

I?iaaaeaiu enneaaeiaaiey oeceei – oeie/aneeo e oaoiieiae/aneeo naienoa
aniiiiaaoaeueiuo aauanoa, oaiieueiiai aeae?ioiaiiai i?aia?aoa i?iiieena
(OAII), eiioeaio?e?iaaiiuo ?anoai?ia e iaiu, iieo/aaiie ec ay?icieueiiai
aaeeiia.

Enneaaeiaaiey oaiieueiiai aeae?ioiaiiai i?aia?aoa i?iiieena
i?iaiaeeeenue a aeaea 1 % nie?oiauo ?anoai?ia.

Eco/aiu eieeieaeii-ieoeaeey?iua naienoaa aiaeiuo ?anoai?ia
aeieniiieeia?ia e iaiiia?aciaaoaeae a eiioeaio?aoeee io 0,009 aei 5,0 %.

Onoaiiaeaii, /oi a oaoiieiae/aneeo ?ac?aaioeao iaiiiai ay?icieueiiai
i?aia?aoa iiaoo auoue eniieueciaaiu i?ienaiie 268, IN-20, oaei-80,
eioi?ua ioiinyony e eeanno iaeiiiaaiiuo iiaa?oiinoii-aeoeaiuo aauanoa
(IIAA).

Enneaaeiaaiu ?aaeiae/aneea naienoaa ay?icieueiuo eiioeaio?aoia,
ninoiyueo ec i?aia?aoa IN-20 (i?ienaiiea 268) e nie?oia neioaoe/aneeo
aee?iuo ia?ae/iuo o?aeoeee N16-N21 (iineaaeiea auee aaaaeaiu a ninoaa
i?aia?aoa a ea/anoaa noaaeeecaoi?a eieeieaeiie nenoaiu). Iieacaii, /oi
aneaaenoaee caiaiu IN-20 ia i?ienaiie 268 ay?icieueiua eiioeaio?aou
i?iyaeytho aiaeiae/iua oeceei-oeie/aneea naienoaa a niioiioaiee 1:6,4.

Onoaiiaeaii aeeyiea eiee/anoaa i?iiaeeaioa — oeaaeiia 12 ia iieacaoaee
ea/anoaa ay?icieueiuo iai, oaeeo eae ayceinoue, nia/eaathuay
niiniaiinoue, “a?aiy aeecie iaiu”, ieioiinoue, i?ioeaio auaea/e ec
ay?icieueiiai aaeeiia, a oaeaea oei auaea/e iaiu, eioi?ua
?aaeaiaioe?othony iauae noaoueae “Ay?iciee” AO O? ecaeaiey e
o?aaiaaieyi, i?aaeuyaeyaiui e ay?icieueiui i?aia?aoai. Iieacaii, /oi
iioeiaeueiia niaea?aeaiea i?iiaeeaioa a i?aia?aoa 5,0 a, eioi?ia
iaania/eaaao ay?icieueiie nenoaia noaaeeueiinoue, aunieoth noaiaiue
aunaiaiaeaeaiey aeaenoaothuaai aauanoaa, i?ieiiae?iaaiiue yooaeo.

Eco/aii aeeyiea eiioeaio?aoeee OAII ia eiinenoaioiua naienoaa
ay?icieueiuo eiioeaio?aoia e iai. Onoaiiaeaii, /oi OAII iacia/eoaeueii
aeeyao ia no?oeoo?ioth ayceinoue ia?acoeia.

?ac?aaioai ninoaa ay?icieueiiai i?aia?aoa “I?ioacieue – iaiiue”:
Oaiieueiiai aeae?ioiaiiai i?aia?aoa i?iiieena – 0,25 a, nie?oa yoeeiaiai
?aeoeoeeiaaiiiai 95% — 2,5 a, i?aia?aoa IN-20 – 0,625 a (eee i?ienaiiea
268 – 4,0 a), aiaeu i/euaiiie – 21,0 a (eee 17,625 a), oeaaeiia 12 – 5,0
a.

N oeaeueth ii?aaeaeaiey ea/anoaaiiuo oa?aeoa?enoee ?ac?aaioaiiiai
ay?iciey “I?ioacieue – iaiiue” eco/aiu aai i?aaiieaioe/aneea (aiaoiee
aeae, oeaao e caiao) e oeceei-oeie/aneea naienoaa (i?ioeaio auaea/e
ay?icieueiiai aaeeiia, eieeieaeiay e oa?iinoaaeeueiinoue).

Ii ?ac?aaioaiiui iaoiaeeeai ea/anoaaiiiai e eiee/anoaaiiiai aiaeeca
ay?icieueiiai i?aia?aoa e ii niaea?aeaieth noiiu oaiieueiuo niaaeeiaiee
iieo/aia iauaeoeaiay ioeaiea ea/anoaa ay?iciey. ?acoeueoaou
enneaaeiaaiee auee o/oaiu i?e ?ac?aaioea i?iaeoa AON.

Aioeiee?iaiay aeoeaiinoue 1% nie?oiauo ?anoai?ia OAII, ay?icieueiiai
i?aia?aoa e 1% aiaeiuo ?anoai?ia IN-20, i?ienaiiea 268 eco/aeanue
iauai?eiyoui a oa?iaoeaaoe/aneie i?aeoeea iaoiaeii aaa?iauo ieanoeiie.
Iieacaii, /oi i?aia?ao i?iyaeyao iaeaieueooth aeoeaiinoue a ioiioaiee
iaei/eiaie e eieeiaie iee?ioei?u. ?anoai?u aniiiiaaoaeueiuo aauanoa ia
iaeaaeatho aioeiee?iaiie aeoeaiinoueth.

Noaaeeueiinoue i?aia?aoa “I?ioacieue – iaiiue” auea eco/aia ia
i?ioyaeaiee aeaoo eao i?e o?aiaiee a oneiaeyo oieiaeeeueieea (4(2IN) e
i?e eiiiaoiie oaiia?aoo?a (18(2IN) a caueuaiiii io naaoa ianoa.
Iieacaii, /oi ay?icieueiue i?aia?ao “I?ioacieue – iaiiue” noaaeeai a
oa/aiea 2 eao o?aiaiey (a?aiy iaaethaeaiey). Iieo/aiiua ?acoeueoaou auee
eniieueciaaiu i?e ?ac?aaioea i?iaeoa AON.

Aeieiae/aneeie enneaaeiaaieyie iieacaii iaee/ea i?ioeaieo/aaiai e
?aia?aoeaiiai yooaeoa ay?icieueiiai i?aia?aoa “I?ioacieue – iaiiue”.
Aaca?aaeiinoue i?aia?aoa iiaeoaa?aeaeaia ?acoeueoaoaie eco/aiey
aeea?aece?othuaai, ianoii?acae?aaeathuaai aeaenoaey, ino?ie e
o?iie/aneie oiene/iinoe ia eaai?aoi?iuo aeeaioiuo.

Eeth/aaua neiaa: oaiieueiue aeae?ioiaiue i?aia?ao i?iiieena, ay?icieue,
oaoiieiaey.

Aao?ae I. A. ?ic?iaea oa aeine?aeaeaiiy i?iiiai aa?icieueiiai i?aia?aoo
aeey e?eoaaiiy o?aaeaiue, oa?ie/ieo oa o?i?/ieo ii?e?a. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa oa?iaoeaaoe/ieo
iaoe ca niaoe?aeuei?noth 15.00.01 – oaoiieia?y e?e?a oa i?iieneiaa
oa?iaoe?y. – Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y, Oa?e?a, 1999.

?ic?iaeaiee oa aeine?aeaeaiee ninoaa i?iiiai aa?icieueiiai i?aia?aoo
“I?ioacieue i?iiee” aeey e?eoaaiiy i?ii?iaaeo o?aaeaiue, oa?i?/ieo oa
o?i?/ieo ii?e?a.

I?iaaaeai? aeine?aeaeaiiy o?ceei – o?i?/ieo oa oaoiieia?/ieo
aeanoeainoae aeiiii?aeieo ?a/iaei, OAII, eiioeaio?ao?a oa aa?icieth.
Aea/ai? iieacieee yeino? aa?icieth, noaa?euei?noue o i?ioean?
caa??aaiiy, a?ieia?/ia aeoeai?noue.

Eeth/ia? neiaa: oaiieueiee a?ae?ioiaiee i?aia?ao i?iiie?no, aa?icieue,
oaoiieia?y.

Batrak E. A. Elaboration and investigation of foamy aerosol drag for
treatment of radiation damages, thermal and chemical burns. –
Manuscript.

The thesis for Master’s Degree in Pharmacy in Speciality 15.00.01 –
Technology of Drags and industrial Pharmacy; Ukrainian Academy of
Pharmacy, Kharkov, 1999.

Composition of foamy aerosol drag “Prophesolum – spumosum” for the
treatment of radiation damages, thermal and chemical burns has been
worked and investigated.

Investigations of physico-chemical and technological properties of
aerosol carried out. Indexes of were guality stability in stovage
biological activity of aerosol have been studied.

Key words: phenolic hydrophobic propolis preparation, aerosol,
technology.

PAGE 10 PAGE 10

1

2

3

4

6

6

8

10

11

12

13

Похожие записи