2

EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO AAIAOIEIA?? OA IA?AEEAAIIss
E?IA?EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO AAIAOIEIA?? OA IA?AEEAAIIss
E?IA?

iiC OE?A?IEiiC OE?A?IE

Ia i?aaao ?oeiieno

AeAIEETHE ?AI? ?AAIIAE*AeAIEETHE ?AI? ?AAIIAE*

OAeE 612.017.1:616-006.446.2

?IEUe IINIIIEIIIEAIAIOA?II? OA OAAIOeEOA?II? NENOAI A IAOIAAIAC?
O?II?*IIAI E?IOIEAEEICO?IEUe IINIIIEIIIEAIAIOA?II? OA OAAIOeEOA?II?
NENOAI A IAOIAAIAC? O?II?*IIAI E?IOIEAEEICO

14.01.31 — aaiaoieia?y oa o?ainooc?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Ee?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe
?i. I.E.Ooieea IIC Oe?a?ie

IAOEIAEE EA??AIEE: — aeieoi? iaaee/ieo iaoe, i?ioani? Aon?aa Na?oeaia
Aiaoie??aia, i?ioani? eaoaae?e aaiaoieia?? oa o?ainooc?ieia?? Ee?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe ?i.I.E.Ooieea IIC Oe?a?ie

IO?Oe?EI? IIIIAIOE: -aeieoi? iaaee/ieo iaoe, O?aoye Iaoaey Ieeiea?aia,
caa?aeoaa/ a?aeae?eii aaiaoieia?? aeey aei?ineeo Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC
Oe?a?ie

-aeieoi? iaaee/ieo iaoe, Ee?iaiei A?eoi? ?aaiiae/,caa?aeoaa/ a?aeae?eii
aaiaoieia?? ?inoeoooo ee?i?/ii? ?aae?ieia?? Iaoeiaiai oeaio?o
?aae?aoe?eii? iaaeeoeeie AII Oe?a?ie

I?IA?AeIA ONOAIIAA: Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo iieieia??
? ?aae?ieia?? IIC Oe?a?ie, iaoeiai-aeine?aeia a?aeae?eaiiy nenoaiieo
iooeeiieo caoai?thaaiue, i.Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny » 10 ” aa?aciy 1999 ?. i 13-00
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26. 612. 01 a
Ee?anueeiio IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia? (254060, i.Ee?a, aoe.
I.Aa?e?inueeiai, 12)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Ee?anueeiai IAe?
aaiaoieia?? oa ia?aeeaaiiy e?ia? (254060, i.Ee?a, aoe. I.
Aa?e?inueeiai, 12)

Aaoi?aoa?ao ?ic?neaiee “ 25 ” n?/iy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee A.A.Eii?na?aiei

Caaaeueia oa?aeoa?enoeea ?iaioeCaaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. Ceiye?ni? caoai?thaaiiy e?ioi?aeii? oeaieie
noaiiaeyoue iaeio c aieiaieo i?iaeai no/anii? iieiaaiaoieia??, iia’ycaio
c oei, ui aaeeea e?euee?noue oai?eo ? iniaaie na?aaeiueiai ?
i?aoeacaeaoiiai a?eo (Montserrat et al., 1994).

O?ii?/ieee e?ioieaeeic (OEE) na?aae e?ioii?ie?oa?aoeaieo caoai?thaaiue ?
iaea?eueo iioe?aiith iaoieia??th. A?aeiii, ui ia?aa?a OEE
noi?iaiaeaeo?oueny /anoeie (60 — 80%) oneeaaeiaiiyie, ye? a 60 – 70%
aeiaaee?a ? aaciina?aaeiueith i?e/eiith caaeaae? oai?eo (O. A.
Oaeiooaei ? ni?aaao., 1980; A. ?. Ai?iaeia ? ni?aaao., 1985; A. E.
Aa??a, 1985, E.R. Rai , T. Han , 1990; Keating et al., 1993; Batata et
al., 1994).

Aiae?c no/aniiai noaio ?ioiieia?? aeiaiaeeoue, ui /ooeea?noue aei
?icaeoeo ?ioaeoe?eiiai i?ioeano iia’ycaia c iniaeeainoyie ?ioiieia?/ii?
?aaeoeaiino?, oiaoi ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio (I?I) (A.I.
Iayinueeee, Ae.I. Iayinueeee, 1989).

Iaeiae ?ieue ii?ooaiue ianiaoeeo?/ii? ?ioiieia?/ii? ?aaeoeaiino?, ?
cie?aia iiniiieiieaiaioa?ii? nenoaie, i?e OEE caeeoa?oueny ia aeaiee
/an i?aeoe/ii ia aea/aiith.

I?aoe? a?eueoino? aeine?aeiee?a aena?oeththoue aieiaiei /eiii
??ciiiai?oi? aniaeoe ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo a aaiac?
?ioaeoe?eieo oa aooi?ioiieo oneeaaeiaiue OEE (ss.?. Aeaianueea, 1989;
N.A. Aon?aa oa ?i., 1995; R.A. Buckley, R.J. Schiff, 1991).

Iaaeinoaoiuei aea/aiith caeeoa?oueny i?iaeaia aca?iica’yceo aeoeaiino?
I?I c iniaeeainoyie ee?i?/iiai ia?aa?ao OEE, a oaeiae ?ie?
iiniiieiiieaiaioa?ii? nenoaie a aaiac? ?ioaeoe?eieo oa aooi?ioiieo
oneeaaeiaiue OEE.

Eiiieaenia aea/aiiy ci?i a iiniiieiiieaiaioa?i?e ? oaaioeeoa?i?e
nenoaiao a oiiaao iooeeiii? i?ia?an?? ? oeeoinoaoe/ii?
?ioiinoi?an??, a oaeiae a oiiaao aaeoa??aeueiiai ?io?eoaaiiy oa
aooiaa?an?? OEE aeicaieeoue ?ic?iaeoe aeiaeaoeia? ae?aaiinoe/i?,
aeeoa?aioe?eii — ae?aaiinoe/i? oa i?iaiinoe/i? e?eoa??? ia?aa?ao
eaeeiciiai i?ioeano.

Oaeei /eiii, iaiao?aei?noue aea/aiiy aeoeaiino? aoii?aeueieo oa
ee?oeiieo oaeoi??a I?I a iaoiaaiac? OEE ? eiai oneeaaeiaiue ?
aeooaeueiei caaaeaiiyi.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia ?iaioe
iia’ycaia c iaoeiaith oaiaoeeith eaoaae?e aaiaoieia?? oa o?ainooc?ieia??
Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe (EIAII) —
“Aea/aiiy iniaeeainoae ia?aa?ao ee?i?ei-aaiaoieia?/ieo ?en oa oaiiiaio
noano?aeoieo ee?oei i?e e?ioii?ie?oa?aoeaieo oa i??eii?ie?oa?aoeaieo
caoai?thaaiiyo”(? aea?ae. ?a?no?aoe?? 0193U040741). Oaia caoaa?aeaeaia
ia can?aeaii? A/aii? iaaee/ii? ?aaee Ee?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a IIC Oe?a?ie (i?ioieie ?5 a?ae 5.05.93 ?.).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith aeaii? ?iaioe ? ?ic?iaea
i?iaiinoe/ieo, ae?aaiinoe/ieo, aeeoa?aioe?eii-ae?aaiinoe/ieo e?eoa???a
ia?aa?ao OEE oeyoii aea/aiiy iniaeeainoae aeoeaaoe??
iiniiieiiieaiaioa?ii? nenoaie oa ooieoe?? naaiaioiyaea?ieo iaeo?io?e?a o
aeeiai?oe? iooeeiiiai i?ioeano.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/? aeine?aeaeaiiy:

1. Aeine?aeeoe e?oe/io aeoeai?noue nenoaie eiiieaiaioo, aeoeai?noue
iinii?caoe??, ia?aiao?e ee?oeiii? ianiaoeeo?/ii? ?acenoaioiino? a
aeeiai?oe? caoai?thaaiiy.

2. Aea/eoe caeaaei?noue ci?i aeoeaiino? aoii?aeueieo ? ee?oeiieo
oaeoi??a a?ae oeeoinoaoe/ii? ?ioiinoi?an??.

3. Aeine?aeeoe oa?aeoa? ii?ooaiue aeoeaiino? aoii?aeueieo ? ee?oeiieo
oaeoi??a I?I i?e aaeoa??aeueiiio ?io?eoaaii? oa a oiiaao aooiaa?an?? o
oai?eo aac o?aaeaiiy e?ioi?aeiiai aia?aoa iooeeiiei i?ioeanii oa i?e
OEE.

4. ?ic?iaeoe eiiieaen iaoiae?a i?iaiicoaaiiy ?ioaeoe?eieo oa aooi?ioiieo
oneeaaeiaiue OEE.

5. ?ic?iaeoe aeiaeaoeia? ae?aaiinoe/i? oa
aeeoa?aioe?aeueii-ae?aaiinoe/i? e?eoa??? ?ioaeoe?eieo oa aooi?ioiieo
oneeaaeiaiue o?ii?/iiai e?ioieaeeico.

Iaoeiaa iiaecia. Aia?oa aea/aia aeoeai?noue eeane/iiai ?
aeueoa?iaoeaiiai oeyo?a nenoaie eiiieaiaioa, noai iinii?caoe?? oa
?aoeaioe?? iaeo?io?e?a e?ia? o oai?eo ia OEE o aeeiai?oe? iooeeiiiai
i?ioeano. Aecia/aii oa?aeoa? ci?i aoii?aeueieo oa ee?oeiieo ia?aiao??a
I?I ia oe? ?ioaeoe?eieo oa aooi?ioiieo oneeaaeiaiue, a oaeiae i?ney
aieeao oeeoinoaoe/ieo i?aia?ao?a. Ia iniia? aiae?co aeaieo
aeine?aeaeaiue ?ic?iaeai? aeinooii? oa ?ioi?iaoeai? iaoiaee
i?iaiicoaaiiy, ae?aaiinoeee oa aeeoa?aioe?eii? ae?aaiinoeee oneeaaeiaiue
OEE.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeai? iaoiaee
i?iaiicoaaiiy, ae?aaiinoeee oa aeeoa?aioe?eii? ae?aaiinoeee ?ioaeoe?eieo
oa aooi?ioiieo oneeaaeaiue OEE aeicaieythoue oaeineiiaeeoe oi/i?noue
ae?aaiinoeee a ii??aiyii? c caaaeueiii?eeiyoeie ee?i?/ieie iaoiaeaie
a?eueo i?ae o 1,7 ?ace. Aeai? iaoiaee ?ioiieia?/iiai eiio?ieth
ai?iaiaai? a aaiaoieia?/iiio a?aeae?eaii? A?iieoeueei? iaeanii?
ee?i?/ii? e?ea?i?, ui cao?eniaaii aeoaie i?i ai?iaaaeaeaiiy a?ae
15.03.98?.; 22.07.98?. (?aoe. i?iiiceoe?y ?794/6 a?ae 1.07.98?.).
Iaoa??aee ?acoeueoao?a aeine?aeaeaiue ai?iaaaeaeai? a iaaeaaia?/iee
i?ioean ia oeeeeao niaoe?ae?caoe??, oaiaoe/iiai aaeineiiaeaiiy ? ia
ia?aaeaoanoaoe?eieo oeeeeao ia eaoaae?? aaiaoieia?? ? o?ainooc?ieia??
EIAII.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa ? naiino?eiei
iaoeiaei aeine?aeaeaiiyi aaoi?a, yea ia? aaaeeeaa iaoeiaa oa
i?aeoe/ia cia/aiiy. Iniaenoee aianie caeiaoaa/a iieyaaa o aiae?c?
aeooaeueiino? ? nooiaiy aea/aiiy oaie ?iaioe, aeai?? e ii?aoethaaii?
iaoiaeee aeine?aeaeaiiy, i?iaaaeaii? ?ioiieia?/ieo aeine?aeaeaiue ee?oei
e?ia?.

Aeyaeai? caeiiii??iino? noi?ioeueiaaii o aeniiaeao oa iieiaeaiiyo
?iaioe, yea aeiineoueny ia caoeno. Noaoenoe/ia ii?aoethaaiiy iaoa??aeo,
ioe?iea io?eiaieo aeaieo, ai?iaaaeaeaiiy a i?aeoeeo oaae i?iaaaeai?
aeena?oaioii iniaenoi. ?ioiieia?/i? aeine?aeaeaiiy aeeiiai? ia eaoaae??
aaiaoieia?? oa o?ainooc?ieia?? EIAII i?ae ea??aieoeoaii aeieoi?a
iaae. iaoe, i?ioani?a Na?oeaie Aiaoie??aie Aon?ai?.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. O?aaiaioe ?acoeueoao?a
aeine?aeaeaiue aeena?oaoe?eii? ?iaioe aoee aeeeaaeai? a aeiiia?ae? ia
??? Oe?a?inueeiio c’?cae? aaiaoieia?a oa o?ainooc?ieia?a (i. Noie,
1995), ?icoe?aiiio can?aeaii? eaoaae?e aaiaoieia?? oa o?ainooc?ieia??,
eaoaae?e oa?ai?? ?1 EIAII a?ae 11.09.1998 ?.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 4 ?iaioe, c
ieo 3 noaoo? oa 1 oaca aeiiia?ae?. Oaca aeiiia?ae? aoea aeeeaaeaia ia
??? Oe?a?inueeiio c’?cae? aaiaoieia?a oa o?ainooc?ieia?a (i. Noie,
1995). Aea? naiino?ei? noaoo? iaae?oeiaai? a iaaee/iiio aeo?iae?
“A?niee A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo”, iaeia
naiino?eia noaooy iaae?oeiaaia a iaaee/iiio aeo?iae? “E?ea?nueea
ni?aaa”.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 146
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, a?nueiio ?icae?e?a, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e ? nieneo e?oa?aoo?e. Nienie e?oa?aoo?e i?noeoue 242
aeaea?aea. Aeena?oaoe?y ?ethno?iaaia 21 oaaeeoeath, 14 iaethieaie.

Ci?no ?iaioeCi?no ?iaioe

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeine?aeaeaiiy i?iaaaeai? o 98
oai?eo ia OEE a?eii a?ae 40 aei 80 ?ie?a, c yeeo 42 (42,9%) noaiiaeee
ae?iee ? 56 (57,1%) oai?eo — /ieia?ee.

On? ianoaaeai? oai?? aoee ?iciiae?eai? ii a?oiai:

? a?oio neeaee 66 oai?eo ia OEE o ?icai?ioo?e noaae?? caoai?thaaiiy
(Binet — (B — C no.); Rai — (II — III no.)).

Oai?? ? a?oie aoee ?iciiae?eai? ia i?aea?oie:

— ?A i?aea?oia noaiiaeea 33 iaoe??ioe, o yeeo ae?aaiic OEE aoa
anoaiiaeaiee oia?oa ? yeei ?ai?oa ia i?iaiaeeeanue oeeoinoaoe/ia oa?ai?y
(Binet — B no.; Ra? — ?? no.);

— ?A i?aea?oia neeaaeaeany c 18 iaoe??io?a, o yeeo ae?aaiic OEE ?c
?ioaeoe?eii-caiaeueieie i?ioeanaie ??ciiiai?oii? eieae?caoe?? aoa
anoaiiaeaiee oia?oa (Binet — B no.; Rai — ??? no.);

— ?A i?aea?oia neeaea 15 iaoe??io?a, o yeeo ae?aaiic OEE aoa
anoaiiaeaiee oia?oa ? aoa oneeaaeiaiee neiioiiaoe/iith aooi?ioiiith
aaiie?oe/iith aiai??th (A?nat — N no.; Ra? — ??? no.).

?? a?oia aoea i?aaenoaaeaia 17 iaoe??ioaie c OEE, o yeeo an?
aeine?aeaeaiiy i?iaaaeai? /a?ac 6 i?nyoe?a i?ney oeeoinoaoe/ii? oa?ai??
? ye? ia iiiaio aeine?aeaeaiiy ia?aaoaaee a noai? ee?i?ei —
aaiaoieia?/ii? eiiiainaoe?? (Binet — A no.; Rai — II no.).

??? a?oio neeaee 15 iaoe??io?a c OEE o oa?i?iaeuei?e noaae??
caoai?thaaiiy (Binet — N no.; Rai — IV no.).

Ia?oo eiio?ieueio a?oio (IE) noaiiaeee 20 oai?eo c
?ioaeoe?eii-caiaeueieie i?ioeanaie ??cii? eieae?caoe?? aac o?aaeaiiy
e?ioi?aeii? oeaieie iooeeiiei i?ioeanii.

Ae?oao eiio?ieueio a?oio (??E) neeaee 11 oai?eo c aooi?ioiiith
aaiie?oe/iith aiai??th (A?AA) aac o?aaeaiiy e?ioi?aeiiai aia?aoo
iooeeiiei i?ioeanii.

Aeey ii??aiyiiy ?acoeueoao?a aeine?aeaeaiue ianoaaeaii 20 i?aeoe/ii
caei?iaeo in?a ?c /enea aeiii??a.

On?i oai?ei ae?aaiic OEE anoaiiaeaiee ia i?aenoaa? e?eoa???a
ae?aaiinoeee, cai?iiiiiaaieo International Working group CLL (1988).

Noaae?th OEE aecia/aee a?aeiia?aeii ee?i?/ii? eeaneo?eaoe?? ii Rai et
al., 1975 oa Binet et al., 1981.

On? oai?? ia?aaoaaee ia noaoe?iia?iiio e?eoaaii? a aaiaoieia?/ieo
a?aeae?eaiiyo Ee?anueei? oa A?iieoeueei? iaeanieo ee?i?/ieo e?ea?iyo aai
ciaoiaeeeenue ia aeeniaina?iiio niinoa?aaeaii?.

Aea/aiiy aieeao oeeoinoaoe/ii? oa?ai?? ia aeoeai?noue aoii?aeueieo
? ee?oeiieo oaeoi??a I?I i?iaaaeaii o oai?eo ia OEE ?A ? ??? a?oi aac
aoaeue-yeeo oneeaaeiaiue.

?ioiieia?/i? aeine?aeaeaiiy aeeth/aee:

— niiioaiia ?aaeoe?y c i?o?inei?i oao?acie??i (INO) ii iaoiaeo (?ark,
1968) a iiaeeo?eaoe?? Ooa?/a I. A., Iaaei?eiai? A. I., 1978;

— noeioeueiaaia INO — ?aaeoe?y e?iiiie?naoa?eaeii (EIN) ca iaoiaeii
Ee?iiaa A. A., Eioiae?ia A. A., 1982;

— aecia/aiiy e?eueeino? iaeo?io?e?a, aeni?anoth/eo ?aoeaioi?e aei
Fc-o?aaiaioo IgG c iiiiniaoeeo?/ieie aioeaeiaoe?iiaeie ne?iaaoeaie a
?aaeoe?? AA — ooai?aiiy (Oa?a?i N. I. ? ni?aaao., 1978);

— aecia/aiiy e?eueeino? iaeo?io?e?a, aeni?anoth/eo ?aoeaioi?e aei
N3a-eiiiiiaioo eiiieaiaioa (Oeaaeaao A.N., 1978);

— aecia/aiiy e?eueeino? A — e?ioioeeo?a (Oeaaeaao A. N.,1978);

— e?euee?nia aecia/aiiy eiioeaio?aoe?? ne?iaaoeiaiai ?ioiiaeiaoe?ia
eeano G (IgG) iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a aaa?? (Iann?n? oa
ni?aaao., 1965);

— aecia/aiiy eiioeaio?aoe?? oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E)
o ne?iaaooe? e?ia? iaoiaeii i?aoeei?oaoe?? c 3,5% ?ic/eiii
iie?aoeeaiaeeeieth c iie.i. 6000 Ae0 (Aaoeiaa A. oa ni?aaao., 1978);

— aecia/aiiy caaaeueii? e?oe/ii? aeoeaiino? eiiieaiaioo (CEAE) ca
?ic?aooieii oaeoe/iiai e?c?no aecia/aii? e?eueeino? a?eo?ioeeo?a
eiiieaiaioii o aeaiiio ia’?i? ne?iaaoee (Oo??uaa A.A., 1986);

— aecia/aiiy eeane/iiai oeyoo aeoeaaoe?? eiiieaiaioo (EOAE) iaoiaeii
iine?aeiaiiai aeniaaeaiiy on?o eiiiiiaio?a aeueoa?iaoeaiiai eaneaaeo
c?iicaiii (Iayinueeee A. I. oa ni?aaao., 1982);

— aecia/aiiy aeueoa?iaoeaiiai oeyoo aeoeaaoe?? eiiieaiaioo (AOAE)
iaoiaeii ?ieoaaoe?? aeine?aeaeoaaii? ne?iaaoee aaeoeeiith Serratia
Marnesnens (Iayinueeee A. I. oa ni?aaao., 1982);

— aecia/aiiy iinii?/ii? aeoeaiino? ne?iaaoee (IAN) e?ia? (Iayinueeee A.
I. oa ni?aaao., 1982);

— ioe?iea iaaeinoaoiino? aoii?aeueieo ? ee?oeiieo oaeoi??a I?I
i?iaaaeaia ca aeiiiiiaith aeae?eaiiy nooiai?a neiae?iio ?ioiiaeao?oeeoa
(N?Ae) ca iaoiaeeeith Caineiaa I. A. (1986);

— ?iaeaen noeioeyoe?? iaeo?io?e?a (?NI) — ni?aa?aeiioaiiy
oi?iacaiiiceoeaieo iaeo?io?e?a noeioeueiaaiiai oanoo aei
oi?iacaiiiceoeaieo iaeo?io?e?a niiioaiiiai oanoo o %:

OII, noeioeueiaaiee oano %

ICH =

OII, niiioaiiee oano %

— noaoenoe/i? iaoiaee aeine?aeaeaiiy (O?aao A. TH., 1963; Aoaea? ?. A.,
Aaie?i A. A., 1977).

Iaea?aeai? aeai? noaoenoe/ii ii?aoeueiaai? ia IAII. Aeey ioe?iee
aeinoia??iino? a?aei?iiinoae iieaciee?a aeei?enoiaoaaee e?eoa??e
No’thaeaioa-O?oa?a (?). Ioe?iea ca’yceo i?ae ye?nieie iciaeaie
i?iaiaeeeanue ia i?aenoaa? aeaieo, iaea?aeaieo i?e ia/eneaii? e?eoa??y
?2 o a?aeiia?aeiino? c oi?ioeaie, iaaaaeaieie a ea??aieoeoaao ii
aa??aoe?ei?e noaoenoeoe?.

?acoeueoaoe aeine?aeaeaiue. Aiae?c ?acoeueoao?a aeine?aeaeaiiy iieacaa,
ui aei oeeoinoaoe/ii? oa?ai?? o oai?eo ?A i?aea?oie niinoa??aaeinue
??cea cieaeaiiy CEAE, EOAE, i?aeaeuaiiy AOAE, i?i ui na?ae/eoue
aaee/eia ni?aa?aeiioaiiy EOAE/AOAE (E/A=0,73+0,03), a oaeiae ??cea
cieaeaiiy IAN e?ia?, ai?noo IgG ia oe? i?aeaeuaiiy eiioeaio?aoe?? Oe?E o
ii??aiyii? c? caei?iaeie iniaaie (oaae. 1).

Oae ye ?nio? o?niee aca?iica’ycie i?ae iiniiieiiieaiaioa?iith ?
oaaioeeoa?iith nenoaiaie, oi a ?A i?aea?oi? oai?eo ia OEE
niinoa??aaeinue cieaeaiiy e?eueeino? iaeo?io?e?a, aeni?anoth/eo
?aoeaioi?e aei Fc — o?aaiaioo IgG (Fc+) ? N3a — eiiiiiaioa eiiieaiaioo
(C3b+). sse iane?aeie iaaeinoaoiino? ?aoeaioi?iiai aia?aoo iaeo?io?e?a
a?aei?/aii iiieaeaiiy e?eueeino? oi?iacaiiiceoeaieo iaeo?io?e?a (OII) o
niiioaiiiio oa noeioeueiaaiiio INO — oanoao oa ?NI a?aeiinii aeaieo
caei?iaeo in?a (oaa. 1).

Noaae?y ee?i?ei-aaiaoieia?/ii? eiiiainaioe?? (?? a?oia)
oa?aeoa?ecoaaeany i?aeaeuaiiyi CEAE, EOAE, E/A, ai?noo IgG ?
iineeaiiyi IAN ia oe? cieaeaiiy Oe?E o ii??aiyii? c aeaieie ?A
i?aea?oie.

Ee?oeii? ia?aiao?e I?I ?? a?oie oai?eo OEE oaeiae a?aecia/athoueny
ca?eueoaiiyi e?eueeino? Fc+ oa C3b+ iaeo?io?e?a; ca?eueoaiiyi e?eueeino?
OII, a?aeiiaethth/eo INO o niiioaiiiio ? noeioeueiaaiiio oanoao, ?NI
noiniaii aeaieo oai?eo ?A i?aea?oie, aea i?e oeueiio aeuaia?a?aoiaai?
iieacieee aoee cia/ii ieae/eie a?ae aeaieo caei?iaeo in?a (oaa. 1).

Iieacieee oai?eo o oa?i?iaeuei?e noaae?? ( ??? a?oia)
oa?aeoa?ecoaaeenue ??ceei i?aeaeuaiiyi CEAE, Oe?E, iineeaiiyi ye EOAE,
oae ? AOAE c ia?aaaaith eeane/iiai (E/A =1,15+0,03), i?eai?/aiiyi IAN
oa cieaeaiiyi IgG ii a?aeiioaiith aei aeaieo ?? a?oie. Ee?oeii?
ia?aiao?e I?I oa?aeoa?ecoaaeeny cieaeaiiyi ai?noo Fc+ oa C3b+
iaeo?io?e?a; OII, a?aeiiaethth/eo INO o niiioaiiiio ? noeioeueiaaiiio
oanoao, ?NI o ii??aiyii? c aeaieie ?? a?oie oai?eo (oaae. 1).

I?e ia/eneaii? N?Ae ii aeine?aeaeaiei iieacieeai anoaiiaeaii, ui o
oai?eo ia OEE cieaeai? CEAE, IAN, e?euee?noue Fc+ oa C3b+ iaeo?io?e?a
ia?aaaaeii o oai?eo III a?oie.

Oaaeeoey 1

Iieacieee aoii?aeueieo ? ee?oeiieo oaeoi??a ianiaoeeo?/ii?
?acenoaioiino? i?aai?cia a aeeiai?oe? o?ii?/iiai e?ioieaeeico

Iieacieee I?ICaei?ia? iniaeA?oie oai?eo ia OEE?A?????CEAE,
e?o.iae.69,97±3,8550,1±2,14

*54,76±1,76

*68,0±2,2

* ** ***EOAE, e?o.iae.39,45±0,8935,24±1,07

*37,86±1,1849,07±0,97

* ** ***AOAE, e?o.iae.41,12±1,0543,47±1,0239,41±1,01

**42,56±1,04

***E/A0,99±0,020,73±0,03

*0,98±0,02

**1,15±0,03

* ** ***IAN1,173±0,0310,71±0,06

*0,81±0,02

* **0,5±0,04

* ** ***IgG, a/e11,63±0,218,22±0,31

*9,38±0,48

* **9,1±0,62

* ** ***Oe?E, iae.iio.u?e.55,2±2,193,6±1,5

*82,0±1,7

* **125,4±3,42

* ** ***E?euee?noue Fc-aeni?. iaeo?., %80,92±1,0760,45±1,55

*65,88±1,62

*52,93±1,93

* ** ***E?euee?noue C3b – aeni?.iaeo?., %65,84±3,0549,00±1,73

*54,29±1,25

* **35,4±1,41

* ** ***OII, % (niii. oano)10,52±0,368,00±0,47

* 8,28±0,20

*5,85±0,39

* ** ***OII, % (noei. oano)32,81±0,9722,78±1,48

*25,07±0,86

*15,71±0,94

* ** ***ICH3,56±0,112,86±0,09

*3,03±0,09

*2,74±0,17

*

I?ei?oea:

* — noaoenoe/ii aeinoia??ia ??cieoey a?aeiinii caei?iaeo in?a;

** — noaoenoe/ii aeinoia??ia ??cieoey a?aeiinii aeaieo ?A i?aea?oie;

*** — noaoenoe/ii aeinoia??ia ??cieoey a?aeiinii aeaieo ?? a?oie.

Oaeei /eiii, o oai?eo ia OEE niinoa??aathoueny ii?ooaiiy aoii?aeueieo ?
ee?oeiieo oaeoi??a I?I, ye? iaoiiaeai? noi?aneaiith ae??th iooeeiiiai
i?ioeano ua aei ii/aoeo oeeoinoaoe/ii? oa?ai??.

Aieea oeeoinoaoe/ii? oa?ai?? ia aeoeai?noue aoii?aeueieo oa ee?oeiieo
oaeoi??a I?I aoei i?iaaaeaii o oai?eo ia OEE a ?A oa ??? a?oiao.
Aeine?aeaeaiiy aeoeaiino? iiniiieiiieaiaioa?ii? ? oaaioeeoa?ii? nenoai o
oeeo oai?eo i?ney oeeoinoaoe/ii? oa?ai?? oeeeeioinoaiii o aeic? 200
ia/aeiao (eo?niaa aeica — 6,0a) iieacaei, ui ia?oee eo?n o?i?ioa?ai??
(OO) o oai?eo ?A i?aea?oie ia ni?aaey? nooo?aiai aieeao ia CEAE ? IAN,
ai?no Fc+ oa C3b+ iaeo?io?e?a; e?euee?noue OII o niiioaiiiio ?
noeioeueiaaiiio INO-oanoao, aea i?eai?/o? EOAE ? a a?eueo?e i??? AOAE,
oa ni?ey? cieaeaiith IgG oa Oe?E a?aeiinii aeo?aeieo aeaieo (oaae.2).

Oaaeeoey 2

Aieea oeeoinoaoe/ii? oa?ai?? ia aoii?aeuei? oa ee?oeii? oaeoi?e oai?eo
o?ii?/iei e?ioieaeeicii

Iieacieee I?I

Caei?ia? iniaeA?oie oai?eo?A???aei OOi?ney OOaei OOi?ney OOCEAE,
e?o.iae.69,97±3,8550,1±2,14

*47,50±2,63

*68,0±2,2

* 56,53±2,38

* ** ***EOAE, e?o.iae.39,45±0,8935,24±1,07

*28,9±1,07

* **49,07±0,97

*32,66±1,93

* **AOAE, e?o.iae.41,12±1,0543,47±1,0231,5±1,11

* **42,56±1,04

30,73±1,04

* **E/A0,99±0,020,73±0,03

*0,91±0,02

* **1,15±0,03

*1,07±0,06

* ** ***IAN1,173±0,0310,71±0,06

*0,66±0,07

* **0,5±0,04

*0,29±0,078

* ** ***IgG, a/e11,63±0,218,22±0,31

*7,15±0,12

* **9,1±0,62

*6,75±0,35

***Oe?E, iae.iio.u?e.55,2±2,193,6±1,5

*71,7±3,17

* **125,4±3,42

*90,53±5,8

* ** ***E?euee?noue Fc-aeni?. iaeo?., %80,92±1,0760,45±1,55

*59,15±1,43

52,93±1,93

*48,46±0,89

* ***E?euee?noue C3b – aeni?.iaeo?., %65,84±3,0549,00±1,73

*47,95±1,61

35,4±1,41

*32,00±0,74

* ***OII, % (niii. oano)10,52±0,368,00±0,47

* 7,8±0,16

5,85±0,39

* 5,00±0,09

***OII, % (noei. oano)32,81±0,9722,78±1,48

*21,86±1,12

15,71±0,94

*14,1±0,17

***ICH3,56±0,112,86±0,09

*2,587±0,1

2,74±0,17

*2,56±0,01

I?ei?oea:

* — noaoenoe/ii aeinoia??ia ??cieoey oai?eo ?A ? ??? a?oi (aei OO)
a?aeiinii aeaieo caei?iaeo in?a;

** — noaoenoe/ii aeinoia??ia ??cieoey ?A ? ??? a?oi (i?ney OO) a?aeiinii
aeo?aeieo aeaieo (aei OO);

*** — noaoenoe/ii aeinoia??ia ??cieoey ??? a?oie (i?ney OO) a?aeiinii
aeaieo ?A i?aea?oie (i?ney OO).

I?e iiaoi?ieo eo?nao OO o oai?eo ??? a?oie a?aeaoaa?oueny i?eai?/aiiy
CEAE, AOAE ? a a?eueo?e i??? EOAE ia oe? cieaeaiiy IAN, IgG, Oe?E, oa
ciaioaiiy Fc+ oa C3b+ iaeo?io?e?a, ?NI a ii??aiyii? c aeo?aeieie
aeaieie.

I?ney i?iaaaeaii? OO o oai?eo ?A i?aea?oie ia aeyaeaii aeinoia??ieo
ci?i ai?noo OII o niiioaiiiio ? noeioeueiaaiiio INO — oanoao, a
oaeiae ?NI a?aeiinii aeo?aeieo aeaieo (oaae. 2).

I?e ia?aooieo N?Ae aeyaeaii, ui a ?A i?aea?oi? ia niinoa??aa?oueny
iiaeeaeaiiy ?ioiiaeao?oeeoo aoii?aeueieo oa ee?oeiieo oaeoi??a, oiae?
ye o III a?oi? OO ni?ey? iiaeeaeaiith N?Ae.

Anoaiiaeaii, ui ?ioiieia?/iee aeaoaeo i?e OEE ca’ycaiee ia o?eueee ?c
noi?aneaiith ae??th iooeeie, aea ?c canoinoaaiiyi oeeoinoaoe/ieo
i?aia?ao?a.

Aea/aiiy aeoeaiino? iiniiieiiieaiaioa?ii? ? oaaioeeoa?ii? nenoai a
oiiaao aaeoa??aeueiiai ?io?eoaaiiy i?iaiaeeeiny o oai?eo OEE ?A
i?aea?oie, ?acoeueoaoe yeeo ii??aithaaeeny c iieacieeaie oai?eo ?A ?
?E a?oi. Anoaiiaeaii, ui aaeoa??aeueia ?io?eoaaiiy a in?a ?E a?oie
aeeeeea? iineeaiiy CEAE, EOAE; ca?eueoaiiy ai?noo Fc+ oa C3b+
iaeo?io?e?a, IgG, Oe?E oa e?eueeino? OII niiioaiiiai ?
noeioeueiaaiiai INO — oano?a ia oe? cieaeaiiy IAN, ?NI oa AOAE ii??aiyii
c? caei?iaeie iniaaie (oaa. 3).

O oai?eo ia OEE ?A i?aea?oie niinoa??aaeinue i?aeaeuaiiy CEAE, IgG,
Oe?E, ia?aaaaeia iineeaiiy EOAE ia oe? i?eai?/aiiy AOAE (E/
A=1,25+0,05), cieaeaiiy IAN e?ia? a?aeiinii ?acoeueoao?a, iaea?aeaieo o
?A i?aea?oi? oai?eo (oaae. 3).

Ee?oeii? ia?aiao?e oai?eo ?A i?aea?oie oa?aeoa?ecoaaeenue i?aeaeuaiiyi
ai?noo Fc+ oa C3b+ iaeo?io?e?a, ca?eueoaiiyi e?eueeino? OII o
niiioaiiiio oa noeioeueiaaiiio INO-oanoao ia oe? cieaeaiiy ?NI o
ii??aiyii? c ?acoeueoaoaie oai?eo ?A i?aea?oie (oaae. 3).

I?e ia/eneaii? N?Ae o oai?eo IA i?aea?oie aeyaeaii iayaiee
?ioiiaeao?oeeo aoii?aeueieo oa ee?oeiieo oaeoi??a, yeee iiaeeaeth?
?ioaeoe?eiee i?ioean.

Aeiaaaeaii, ui aaeoa??aeueia ?io?eoaaiiy aeeeeea? iaeiiiai?aaeai? ci?ie
a iiniiieiiieaiaioa?i?e ? oaaioeeoa?i?e nenoaiao o oai?eo ?c iooeeiiei
i?ioeanii e?ioi?aeii? oeaieie ? o in?a aac o?aaeaiiy e?ioi?aeiiai
aia?aoo.

Aieea neiae?iio aooiaa?an?? ia noai aeoeaiino? iiniiieiiieaiaioa?ii? ?
oaaioeeoa?ii? nenoai aea/aany o oai?eo ?A i?aea?oie, iieacieee yeeo
ii??aithaee c aeaieie ?A ? ??E a?oi. A?aei?/aii, ui aooiaa?an?y a in?a
??E a?oie aeeeeea? i?eai?/aiiy CEAE, AOAE, ?NI ia oe? iineeaiiy IAN,
ca?eueoaiiy ai?noo Fc+ oa C3b+ iaeo?io?e?a, OII o niiioaiiiio oa
noeioeueiaaiiio INO-oanoao, IgG, Oe?E o ii??aiyii? c? caei?iaeie iniaaie
(oaae. 4).

Oaaeeoey 3

Iieacieee iiniiieiiieaiaioa?ii? oa oaaioeeoa?ii? nenoai o oai?eo ia
o?ii?/iee e?ioieaeeic i?e aaeoa??aeueiiio ?io?eoaaii?

Iieacieee I?ICaei?ia? iniaeA?oie oai?eo ia OEE?E?A?ACEAE,
e?o.iae.69,97±3,8586,77±0,98

*50,1±2,14

*79,04±2,07

* ** ***EOAE, e?o.iae.39,45±0,8951,64±0,98

*35,24±1,07

*50,33±0,97

* **AOAE, e?o.iae.41,12±1,0536,14±0,67

*43,47±1,0242,11±1,29

***E/A0,99±0,021,45±0,08

*0,73±0,03

*1,25±0,05

* ** ***IAN1,173±0,0310,71±0,02

*0,71±0,06

*0,68±0,02

* ***IgG, a/e11,63±0,2112,83±0,57

*8,22±0,31

*9,36±0,48

* ** ***Oe?E, iae.iio.u?e.55,2±2,198,7±1,1

*93,6±1,5

*104,72±9,07

* ** ***E?euee?noue Fc-aeni?. iaeo?., %80,92±1,0785,20±0,45

*60,45±1,55

*67,4±1,25

* ** ***E?euee?noue C3b – aeni?.iaeo?., %65,84±3,0570,4±0,3

*49,00±1,73

*54,8±0,2

* ** ***OII, % (niii. oano)10,52±0,3630,5±1,74

*8,00±0,47

*17,89±1,79

* ** ***OII, % (noei. oano)32,81±0,9758,06±2,58

*22,78±1,48

*39,7±1,54

* ** ***ICH3,56±0,111,99±0,01

*2,86±0,09

*1,12±0,01

* ** ***

I?ei?oea:

* — noaoenoe/ii aeinoia??ia ??cieoey a?aeiinii aeaieo caei?iaeo in?a;

** — noaoenoe/ii aeinoia??ia ??cieoey ?A i?aea?oie a?aeiinii aeaieo ?A
i?aea?oie;

*** — noaoenoe/ii aeinoia??ia ??cieoey ?A i?aea?oie a?aeiinii aeaieo ?E
a?oie.

Iieacieee oai?eo ?A i?aea?oie oa?aeoa?ecoaaeenue cieaeaiiyi CEAE, Oe?E,
ia?aaaaeiei iineeaiiyi EOAE o ii??aiyii? c AOAE (E/A =2,94+0,28) ia oe?
i?aeaeuaiiy IAN, IgG a?aeiinii aeaieo ?A i?aea?oie (oaae. 4).

Oaaeeoey 4

Iieacieee iiniiieiiieaiaioa?ii? oa oaaioeeoa?ii? nenoai o

oai?eo ia o?ii?/iee e?ioieaeeic i?e aooiaa?an??

Iieacieee I?ICaei?ia? iniaeA?oie oai?eo ia OEE??E?A?ACEAE,
e?o.iae.69,97±3,8557,81±3,04

*50,1±2,14

*43,6±1,41

* ** ***EOAE, e?o.iae.39,45±0,8942,0±2,0

35,24±1,07

*37,73±1,86

AOAE, e?o.iae.41,12±1,05 20,18±1,52

*43,47±1,0214,66±1,48

* ** ***E/A0,99±0,022,14±0,22

*0,73±0,03

*2,94±0,28

* ** ***IAN1,173±0,0311,24±0,05

0,71±0,06

*0,88±0,06

* ** ***IgG, a/e11,63±0,2113,42±0,53

*8,22±0,31

*9,3±0,56

* ** ***Oe?E, iae.iio.u?e.55,2±2,191,81±5,52

*93,6±1,5

*90,66±1,11

* ** ***E?euee?noue Fc-aeni?. iaeo?., %80,92±1,0785,4±0,8

*60,45±1,55

*67,8±1,2

* ** ***E?euee?noue C3b – aeni?.iaeo?., %65,84±3,0572,6±0,9

49,00±1,73

*58,3±0,78

* ** ***OII, % (niii. oano)10,52±0,3614,5±0,7

*8,00±0,47

*11,4±0,2

* ** ***OII, % (noei. oano)32,81±0,9736,8±0,2

*22,78±1,48

*26,8±0,11

* ** ***ICH3,56±0,113,31±0,1

2,86±0,09

*2,3±0,04

* ** ***

I?ei?oea:

* — noaoenoe/ii aeinoia??ia ??cieoey a?aeiinii aeaieo caei?iaeo in?a;

** — noaoenoe/ii aeinoia??ia ??cieoey ?A i?aea?oie a?aeiinii aeaieo ?A
i?aea?oie;

*** — noaoenoe/ii aeinoia??ia ??cieoey ?A i?aea?oie a?aeiinii aeaieo ??E
a?oie.

Ee?oeii? ia?aiao?e oai?eo ?A i?aea?oie a?aecia/aeenue ca?eueoaiiyi
ai?noo Fc+ oa C3b+ iaeo?io?e?a, i?aeaeuaiiyi e?eueeino? OII o
niiioaiiiio oa noeioeueiaaiiio INO-oanoao oa cieaeaiiyi ?NI o ii??aiyii?
c aeaieie ?A i?aea?oie (oaae. 4).

Aiae?c N?Ae aoii?aeueieo ? ee?oeiieo oaeoi??a iieacaa, ui aooiaa?an?y,
yea aeieea? ia oe? aeenaaeaino ?ioiieia?/ii? ?aaeoeaiino?, i?ioiaeeoue n
aeao?oeeoii oaeoi??a I?I.

A?aei?/aii, ui neiae?ii aooiaa?an?? aeeeeea? ??ciiiai?oi? ci?ie
aeoeaiino? aoii?aeueieo oa ee?oeiieo oaeoi??a I?I o oai?eo ?c iooeeiiei
i?ioeanii e?ioi?aeii? oeaieie oa o in?a aac o?aaeaiiy e?ioi?aeiiai
aia?aoo.

Iaea?aeai? ?acoeueoaoe iiaeooue aooe canoiniaai? aeey i?iaiicoaaiiy,
ae?aaiinoeee oa aeeoa?aioe?eii? ae?aaiinoeee aaeoa??aeueiiai ?io?eoaaiiy
? neiae?iio aooiaa?an?? o oai?eo OEE c iaoith i?ecia/aiiy aaeaeaaoii?
oa?ai??.

Aeniiaee Aeniiaee

1. O oai?eo ia o?ii?/iee e?ioieaeeic niinoa??aa?oueny eiiieaen ee?i?ei —
?ioiieia?/ieo ii?ooaiue, yeee oyaey? niaith aoi?eiiee ?ioiiaeaoeoeeo ?
iaoiiaeaiee oa?aeoa?ieie aeey OEE ?iceaaeaie.

2. Iniiaieie iaoiaaiaoe/ieie iaoai?ciaie ii?ooaiue ianiaoeeo?/ii?
?ioiieia?/ii? ?aaeoeaiino? i?e OEE ? aeaoaeoe ?ioiii? nenoaie, ye?
iia’ycai? c ae??th i?ia?anoth/i? iooeeie, a oaeiae ?ioiieia?/i?
?iceaaee, ye? aeieeathoue i?ney canoinoaaiiy oeeoinoaoe/ieo i?aia?ao?a.

3. Aeey OEE oa?aeoa?ia i?eai?/aiiy e?oe/ii? aeoeaiino? eiiieaiaioo, eiai
eeane/iiai oeyoo aeoeaaoe??, iinii?/ieo aeanoeainoae ne?iaaoee,
cieaeaiiy aioeo?eiooai?aiiy, i?eai?/aiiy ?aoeaioe?? iaeo?io?eaie oa
aioo??oiueiee?oeiiiai eeniaaicaeaaeiiai iaoaaie?cio. I?ia?an?y
iooeeiiiai i?ioeano ni?ey? iineeaiith aeoeaiino? eiiieaiaioo, eiai
eeane/iiai oeyoo aeoeaaoe??, iiaeaeueoiio cieaeaiith iinii?/ieo
aeanoeainoae ne?iaaoee e?ia?, aioeo?eiooai?aiiy ? ooieoe?iiaeueieo
aeanoeainoae iaeo?io?e?a ia oe? cia/iiai i?aeaeuaiiy eiioeaio?aoe??
Oe?E.

4. Iinooeeoinoaoe/iee ?ioiieia?/iee aeaoaeo ianiaoeeo?/ii?
?acenoaioiino? caeaaeeoue a?ae oiia i?iaaaeaiiy oa?ai??: i?ney ia?oiai
eo?no oeeoinoaoe/ii? oa?ai?? niinoa??aa?oueny iii??ia i?eai?/aiiy
e?oe/ii? aeoeaiino? eiiieaiaioo, iaio eiai oeyo?a aeoeaaoe?? oa
cieaeaiiy eiioeaio?aoe?? Oe?E. I?e iiaoi?ieo eo?nao oeeoinoaoe/ii?
oa?ai?? niinoa??aa?oueny ca?eueoaiiy i?eai?/aiiy aoii?aeueieo ?
ee?oeiieo ia?aiao??a ianiaoeeo?/ii? ?acenoaioiino?.

5. Iniiaieie iaoiaaiaoe/ieie iaoai?ciaie ?icaeoeo ?ioaeoe?eii —
caiaeueieo oneeaaeiaiue OEE ? cia/ia cieaeaiiy e?oe/ii? aeoeaiino?
eiiieaiaioo oa iinii?/ii? aeoeaiino? ne?iaaoee e?ia?.

6. Noai ?ioiieiiiaoaioiino? oai?eo ia OEE caeaaeeoue a?ae ?ioiieo
ii?ooaiue, aeeeeeaieo ?ioaeoe?eiith noi?an??th. Aeaoaeoe ianiaoeeo?/ii?
?ioiieia?/ii? ?aaeoeaiino? i?aai?cio oai?eo ia OEE a oiiaao
aaoa??aeueiiai ?io?eoaaiiy neeaaeathoueny c aeoeaaoe?? caaaeueii?
e?oe/ii? aeoeaiino? eiiieaiaioo, ia?aaaaeii? aeoeaaoe?? eiai eeane/iiai
oeyoo, i?eai?/aiiy iinii?/ii? caeaoiino? ne?iaaoee, ca?eueoaiiy
eiioeaio?aoe?? iaeo?io?e?a, aeni?anoth/eo Fc — ? N3a — ?aoeaioi?e ?c
iineeaiiyi aioo??oiueiee?oeiiiai iaoaaie?cio oa eiioeaio?aoe?? Oe?E.

7. Aeaoaeoe ianiaoeeo?/ii? ?acenoaioiino? a oiiaao aooiaa?an?? i?e OEE
neeaaeathoueny c i?eai?/aiiy caaaeueii? e?oe/ii? aeoeaiino? eiiieaiaioo,
aeueoa?iaoeaiiai oeyoo nenoaie eiiieaiaioo, Oe?E, i?aeaeuaiiyi
eiioeaio?aoe?? Fc ? NCa-aeni?anoth/eo iaeo?io?e?a, IgG.

I?aeoe/i? ?aeiiaiaeaoe??I?aeoe/i? ?aeiiaiaeaoe??

1. Ee?i?ei — ?ioiieia?/i? iieacieee oai?eo ia o?ii?/iee e?ioieaeeic
aeioe?eueii aeei?enoiaoaaoe aeey ioe?iee iioe?aiiy eaeeiciiai i?ioeano,
i?iaiicoaaiiy ia?aa?ao caoai?thaaiiy, ?eceeo aeieeiaiiy ?ioaeoe?eii —
caiaeueieo oa aooi?ioiieo oneeaaeiaiue.

2. Aeey i?iaiicoaaiiy ?ioaeoe?eieo oneeaaeiaiue o?ii?/iiai e?ioieaeeico
?aeiiaiaeiaaii aecia/aiiy iieaciee?a ianiaoeeo?/iiai caoenoo, iaea?eueo
?ioi?iaoeaieie c yeeo ? iinii?/ia aeoeai?noue ne?iaaoee e?ia? oa
caaaeueia e?oe/ia aeoeai?noue eiiieaiaioo.

3. C iaoith ?aiiuei? ae?aaiinoeee ?ioaeoe?eiiai i?ioeano
?aeiiaiaeiaaii aecia/aiiy aeoeaiino? eiiieaiaioo, eeane/iiai oa
aeueoa?iaoeaiiai oeyo?a, a oaeiae ni?aa?aeiioaiiy i?ae eeane/iei oa
aeueoa?iaoeaiei oeyoaie.

4. Iaoiaeaie i?iaiicoaaiiy ? ae?aaiinoeee aooi?ioiieo oneeaaeiaiue ?
aecia/aiiy aeueoa?iaoeaiiai ? eeane/iiai oeyo?a aeoeaaoe?? eiiieaiaioo.

5. Ae?oa?aioe?aeueii-ae?aaiinoe/ieie oanoaie ?ioaeoe?eieo oa aooi?ioiieo
oneeaaeiaiue OEE iiaea aooe aecia/aiiy aeoeaiino? eeane/iiai oeyoo oa
caaaeueii? e?oe/ii? aeoeaiino? eiiieaiaioo.

6. Aeey i?iaiicoaaiiy aaaeeino? o?ii?/iiai e?ioieaeeico ?aeiiaiaeiaaii
aecia/aiiy caaaeueii? e?oe/ii? aeoeaiino? eiiieaiaioo oa Oe?E.

7. I?ney iiaoi?ieo eo?n?a o?i?ioa?ai?? ?aeiiaiaeiaaii i?iaiaeeoe
eiio?ieue ca aeoeai?noth aoii?aeueieo oaeoi??a ianiaoeeo?/iiai caoenoo
c iaoith nai?/aniiai i?ecia/aiiy aaeaeaaoii? oa?ai??.

Nienie iaoeiaeo i?aoeue, iioae?eiaaieo ca oaiith aeena?oaoe??

1. Aeaieethe ?.?. Aeeiai?ea nenoaie eiiieaiaioa o oai?eo ia o?ii?/iee
e?ioieaeeic. // A?niee A?iieoeueeiai aea?ae. iaae. oi-oo.— 1997. — ?2.-
n.56-57.

2. Aeaieethe E.E. Aeeyiea oeeoinoaoe/aneie oa?aiee ia iieacaoaee
aoii?aeueiuo oaeoi?ia ianiaoeeoe/aneie ?aaeoeaiinoe i?aaiecia aieueiuo
o?iie/aneei eeioieaeeicii // A?a/. aeaei. — 1998.— ?2.— n.91-93.

3. Aeaieethe ?.?. Noai ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio o oai?eo
ia o?ii?/iee e?ioieaeeic c ee?i?/ieie i?iyaaie ?ioaeoe?eii-caiaeueiiai
i?ioeano // A?niee A?iieoeueeiai aea?ae. iaae. oi-oo.— 1998.-?1.—
c.92-93.

4. Aon?aa N.A., Eeeiaiei E.I., Aeaieethe ?.?. ?ieue aoii?aeueieo
oaeoi??a ?ioiieia?/iiai caoenoo a aaiac? aaeoa??aeueieo oneeaaeiaiue i?e
e?ioii?ie?oa?aoeaieo caoai?thaaiiyo. // ??? Oe?a?inueeee c’?cae
aaiaoieia?a ? o?ainooc?ieia?a, 23-25 o?aai., 1995?., i. Noie: Oace
aeiee.— E.- 1995.- n.37.  

Aiioaoe?yAiioaoe?y

Aeaieethe ?. ?. ?ieue iiniiieiiieaiaioa?ii? oa oaaioeeoa?ii? nenoai a
iaoiaaiac? o?ii?/iiai e?ioieaeeico. — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.31-aaiaoieia?y oa o?ainooc?ieia?y — Ee?anueeee
iaoeiai-aeine?aeiee ?inoeooo aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC
Oe?a?ie, Ee?a, 1999.

Aeena?oaoe?th i?enay/aii aea/aiith aeoeaiino? iiniiieiiieaiaioa?ii? oa
oaaioeeoa?ii? nenoai o oai?eo ia OEE a aeeiai?oe? iooeeiiiai i?ioeano,
ia oe? ?ioaeoe?eieo oa aooi?ioiieo oneeaaeiaiue, a oaeiae i?ney aieeao
oeeoinoaoe/ieo i?aia?ao?a.

Anoaiiaeaii, ui ci?ie aeoeaiino? iiniiieiiieaiaioa?ii? ? oaaioeeoa?ii?
nenoai caeaaeaoue a?ae ia??iaeo ? noaae?? OEE. ?ic?iaeai? iaoiaee
i?iaiicoaaiiy, ae?aaiinoeee oa aeeoa?aioe?aeueii? ae?aaiinoeee
oneeaaeiaiue OEE, ye? aeicaieythoue i?iaiaeeoe ?ioiieia?/iee eiio?ieue
ca ia?aa?aii eaeeiciiai i?ioeano c iaoith i?ecia/aiiy aaeaeaaoii?
oa?ai??.

Eeth/ia? neiaa: o?ii?/iee e?ioieaeeic; iiniiieiiieaiaioa?ia oa
oaaioeeoa?ia nenoaie, ?ioiieia?/iee eiio?ieue.

Aiiioaoeey Aiiioaoeey

Aeaieethe E. E. ?ieue iiniiieiiieaiaioa?iie e oaaioeeoa?iie nenoai a
iaoiaaiaca o?iie/aneiai eeioieaeeica. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/?iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.31 — aaiaoieiaey e o?ainooceieiaey — Eeaaneee
iao/ii-enneaaeiaaoaeueneee einoeooo aaiaoieiaee e ia?aeeaaiey e?iae IC
Oe?aeiu, Eeaa, 1999.

Aeenna?oaoeey iinayuaia eco/aieth aeoeaiinoe iiniiieiiieaiaioa?iie e
oaaioeeoa?iie nenoai o aieueiuo OEE a aeeiaieea iiooieaaiai i?ioeanna,
ia oiia eioaeoeeiiiuo e aooieioiiuo ineiaeiaiee, a oaeaea iinea
aicaeaenoaey oeeoinoaoe/aneeo i?aia?aoia.

Onoaiiaeaii, /oi eciaiaiea aeoeaiinoe iiniiieiieaiaioa?iie e
oaaioeeoa?iie nenoai caaeneo io ia?eiaea e noaaeee OEE.

Aei ia/aea oeeoinoaoe/aneie oa?aiee aoii?aeueiua oaeoi?u o aieueiuo
OEE IA-iiaea?oiiu oa?aeoa?eciaaeenue oaiaoaieai iauae eeoe/aneie
aeoeaiinoe eiiieaiaioa (IEAE), nieaeaieai aeoeaiinoe eeanne/aneiai
eaneaaea nenoaiu eiiieaiaioa n i?aeiouanoaaiiie aeoeaaoeeae
aeueoa?iaoeaiiai eaneaaea.

Aiaeec ?acoeueoaoia IEAE o aieueiuo IA-iiaea?oiiu iieacae, /oi o
eeoe ni cia/aieai IEAE ieaea n?aaeianoaoenoe/aneeo aeey yoie iiaea?oiiu
iaaethaeaeenue /anoua (aei 75%) eioaeoeeiiii-ainiaeeoaeueiua
ineiaeiaiey, a oi a?aiy eae aeey eeoe ni cia/aieyie IEAE auoa
n?aaeianoaoenoe/aneeo oa?aeoa?ii aieaa aa?anneaiia oa/aiea eaeeiciiai
i?ioeanna. Ia yoii iniiaaiee ii?aaeaeaiea IEAE iineoaeeei iiaiaeii aeey
?ac?aaioee i?iaiinoe/aneiai e?eoa?ey oa/aiey OEE. Eeaoi/iua ia?aiao?u
aieueiuo IA-iiaea?oiiu oa?aeoa?eciaaeenue oaiaoaieai aeoeaiinoe
?aoeaioi?iiai aiia?aoa iaeo?ioeeia; nieaeaieai aioo?eeeaoi/iiai
eenei?iaeicaaeneiiai iaoaaieecia iaeo?ioeeia ii n?aaiaieth n
?acoeueoaoaie caei?iauo eeoe.

Noaaeey eeeieei-aaiaoieiae/aneie eiiiainaoeee i?ioeanna (II a?oiia
aieueiuo OEE) oa?aeoa?eciaaeanue iaaeinoiaa?iui iiauoaieai aeoeaiinoe
aoii?aeueiuo e eeaoi/iuo oaeoi?ia ianiaoeeoe/aneie ?acenoaioiinoe
i?aaiecia (I?I) ii n?aaiaieth n iieacaoaeyie IA-iiaea?oiiu.

A oa?ieiaeueiie noaaeee (III a?oiia aieueiuo OEE) iaaethaeaeinue
oneeaiea IEAE, eeanne/aneiai eaneaaea ia oiia ?aceiai oaiaoaiey
aeoeaiinoe ?aoeaioi?iiai aiia?aoa iaeo?ioeeia; nieaeaiea
aioo?eeeaoi/iiai eenei?iaecaaeneiiai iaoaaieecia iaeo?ioeeia ii
n?aaiaieth n iieacaoaeyie IA e II a?oii aieueiuo OEE.

Aiaeec ?acoeueoaoia enneaaeiaaiee iieacae, /oi a aeeiaieea OEE
iaaethaeaaony oaiaoaiea aeoeaiinoe iiniiieiiieaiaioa?iie e oaaioeeoa?iie
nenoai, /oi naeaeaoaeuenoaoao i noi?anneaiii aicaeaenoaee iiooieaaiai
i?ioeanna ia I?I.

Enneaaeiaaiea oa?aeoa?a ia?ooaiee aoii?aeueiuo e eeaoi/iuo oaeoi?ia I?I
a oneiaeyo oeeoinoaoe/aneiai aicaeaenoaey oeeeeioinoaiii i?iaaaeaii o
aieueiuo OEE IA e III a?oii aei e iinea oeieioa?aiee (OO).

Onoaiiaeaii, /oi ia?aue eo?n OO o aieueiuo IA-iiaea?oiiu i?aeoe/anee ia
aeeyao ia IEAE, eeanne/aneee e aeueoa?iaoeaiue eaneaaeu nenoaiu
eiiieaiaioa; aeoeaiinoue ?aoeaioi?iiai aiia?aoa iaeo?ioeeia e
aioo?eeeaoi/iue eenei?iaecaaeneiue iaoaaieeci iaeo?ioeeia ii n?aaiaieth
n enoiaeiuie aeaiiuie. Iiaoi?iua eo?nu OO o aieueiuo OEE III a?oiiu
aucuaaao ?aceia oaiaoaiea (ii n?aaiaieth n iieacaoaeyie aieueiuo
IA-iiaea?oiiu) aeoeaiinoe iiniiieiiieaiaioa?iie e oaaioeeoa?iie nenoai.

Aeieacaii, /oi eiioiieiae/aneee aeaoaeo i?e OEE iaoneiaeai ia oieueei
noi?anneaiui aicaeaenoaeai iiooiee, ii e oeeoinoaoe/aneeie i?aia?aoaie.

Aaeoa?eaeueiia eioeoee?iaaiea eae o eeoe aac ii?aaeaiey eeioieaeiiai
aiia?aoa iiooieaaui i?ioeannii (IE a?oiia), oae e o eeoe n OEE (IA
iiaea?oiia) aucuaaao iaeiiiai?aaeaiiua eciaiaiey, o.a. oneeaiea IEAE,
eeanne/aneiai eaneaaea nenoaiu eiiieaiaioa, oaiaoaiea iiniie/aneie
aeoeaiinoe nuai?ioee (IAN) e?iae ia oiia oneeaiey aeoeaiinoe
?aoeaioi?iiai aiia?aoa iaeo?ioeeia e aioo?eeeaoi/iiai
eenei?iaeicaaeneiiai iaoaaieecia iaeo?ioeeia.

Neiae?ii aooiaa?annee o eeoe aac ii?aaeaiey eeioieaeiiai aiia?aoa
iiooieaaui i?ioeannii (IIE a?oiia) e o eeoe n OEE (IA iiaea?oiia)
aucuaaao ?aciiiai?aaeaiiua eciaiaiey aeoeaiinoe aoii?aeueiuo e eeaoi/iuo
oaeoi?ia I?I, o.a. oaiaoaiea IEAE, aeueoa?iaoeaiiai eaneaaea eiiieaiaioa
ia oiia iiauoaiey aeoeaiinoe ?aoeaioi?iiai aiia?aoa iaeo?ioeeia,
aioo?eeeaoi/iiai eenei?iaeicaaeneiiai iaoaaieecia iaeo?ioeeia.

Ia iniiaaiee ?acoeueoaoia enneaaeiaaiee ?ac?aaioaiu iaoiaeu
i?iaiice?iaaiey, aeeaaiinoeee e aeeooa?aioeeaeueiie aeeaaiinoeee
ineiaeiaiee OEE, eioi?ua iicaieytho inouanoaeyoue eiioiieiae/aneee
eiio?ieue ca oa/aieai eaeeiciiai i?ioeanna n oeaeueth iacia/aiey
aaeaeaaoiie oa?aiee.

Eeth/aaua neiaa: o?iie/aneee eeioieaeeic; iiniiieiiieaiaioa?iay e
oaaioeeoa?iay nenoaiu, eiioiieiae/aneee eiio?ieue.

AnnotationAnnotation

Danilyuk I. I. The role of the opsone — complementary and phagocytic
systems in the pathogenesis of chronic lymphocytic leukemia. —
Manuscript.

Thesis for receiving the academic degree of the candidate of medical
sciences in speciality 14.01.31 — hematology and blood transfusion —
Kiyiv Scientific Research Institute of Hematology and Transfusiology
Ministry of Health of the Ukraine, Kiyiv, 1999.

The dissertation is devoted to the studing activities of the opsone —
complementary and phagocytic systems in patients with CLL in the
dynamic of the leukemic processs. This studing is held on the
background of autoimmune complications and after an influence of the
cytostatic treatment.

It has been considered that the changing of the opsonecomplementary
and phagocytic systems activities are depended upon a stage and
period of CLL.

The method of prognosis, diagnostic and differential diagnostic of
CLL and its complications have been worked out that allow us to
realize an immunologic control of a leukemic processs with the aim
of an adequate therapy.

Key words: immunologic control, opsone — complementary and phagocytic
systems, chronic lymphocytic leukemia.

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