Iaoe?iiaeueia Aeaaeai?y Iaoe Oe?a?ie

?inoeooo o?c?ieia?? ?i. I.I.Aiaiiieueoey

Aiy?/oe Ieaia Aeieo??aia

OAeE 612.112.155.34/.39

?ieue e?ciniiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a o oi?ioaaii?
neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai

cn?aeaiiy e?ia?

03.00.13 — o?c?ieia?y ethaeeie ? oaa?ei

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaeaaia?/iiio ?inoeooo? ?i.
O.A.Oaa/aiea

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

Eoi?ia Iaee? Aanee?aia,

Eoaainueeee aea?aeaaiee iaaeaaia?/iee ?inoeooo ?i. O.A.Oaa/aiea,

caa?aeoaa/ eaoaae?e o?c?ieia?? ethaeeie

oa aaeaieia??

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Na?aaeaiei Ieoaeei Ieoaeeiae/

?inoeooo o?c?ieia?? ?i. I.I.Aiaiiieueoey

IAI Oe?a?ie

caa?aeoaa/ a?aeae?eo ii aea/aiith a?iiene/ieo noai?a

aeieoi? a?ieia?/ieo iaoe

Aa?aoeueea Oaia?a Aieiaeeie??aia

?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia

IAI Oe?a?ie

i?ia?aeiee iaoeiaee ni?a?ia?oiee

I?ia?aeia onoaiiaa: ?inoeooo aa?iioieia?? AII Oe?a?ie

Caoeno a?aeaoaeaoueny “ 29 ” a?oaeiy 1998 ?ieo i 14-00 aiaeei? ia

can?aeaii? niaoe?aeueii? a/aii? ?aaee Ae 26. 198. 01 i?e ?inoeooo?
o?c?ieia?? ?i. I.I.Aiaiiieueoey IAI Oe?a?ie (252024 i.Ee?a, aoe.
Aiaiiieueoey, 4).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo o?c?ieia??
?i. I.I.Aiaiiieueoey IAI Oe?a?ie ca aae?anith: 252024 i.Ee?a, aoe.
Aiaiiieueoey, 4.

Aaoi?aoa?ao ?ic?neaiee 26 eenoiiaaea 1998 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? a?ieia?/ieo iaoe
_______________ Ni?ie?ia-Ia??ia C.I.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie

Iaeo?io?euei? a?aioeioeeoe aeyaeythoue aenieee iioaioe?ae ?
aaaaoi-a?aiio ooieoe?iiaeueio aeoeai?noue (aaeaac?y, oaiioaen?n,
?ani??aoi?iee aeaoo, oaaioeeoic, aioo??oiueiee?oeiia o?aaeaiiy,
aioei?e?iaia ? oeeoioiene/ia ae?y), ui na?ae/eoue i?i ?o aaeee? ?aca?ai?
? aaeaioaoe?ei? iiaeeeaino? (A.E.Eociee, I.I.Oeuaeeia, 1981;
A.A.Ieaa?aaneee, 1982; A.Ae.Aaei, A.I.Iayineee, 1983; I.I.Aa?aaeiay,
1988; Ae.F.Bainton, 1976; M.Boodaerts e.a., 1982; J.M.Horlan e.a.,
1985). A?eueo?noue aaoi??a iia’yco? ?ieue iaeo?io?eueieo eaeeioeeo?a,
cie?aia, c ?o o/anoth o oaaioeeoa?ieo ?aaeoe?yo i?e caiaeaii? /e
iioeiaeaeaii? oeaiei, i?e oeueiio aiie a?aecia/athoue ?icaeoie
iaeo?io?eueico ? aeoeaaoe?th a?aioeioeeoiiiaco (A.E.No?oeia, 1980;
A.E.Ai?i-aueaa a niaao., 1985; TH.I.Aaea, n niaao., 1991; I.M.Goldstein,
1984; R.A.Clark, N.Borregaard, 1985,1988).

O ?aae?caoe?? a?ieia?/iiai iioaioe?aeo iaeo?io?eioeeo?a cia/io ?ieue
a?ae?a?a? e?ciniiaeueiee aia?ao oeeo ee?oei. Iaea?eueoa aea/aia o/anoue
e?ciniiaeueieo oa?iaio?a iaeo?io?e?a o ?ioaeoe?eii-caiaethaaeueieo
?aaeoe?yo i?aai?cio (I.A.Ooae/, E.A.Ianoa?iaa, 1980; A.A.Iaeueoeei,
1988; Ae.I.Iayineee, 1991; J.Fallon, J.Gallin, 1986). Naia
e?ciniiaeuei? oa?iaioe iaeo?io?e?a aecia/athoue ye “iaae?aoi?e
caiaeaiiy”, ui iiina?aaeaeothoue ca’ycie iaeo?io?eueieo eaeeioeeo?a c
eaeee?a?i-eei?iiaith nenoaiith ? nenoaiith eiiieaiaioa (A.ss.Eoeueaa?a,
1985; A.I.Iayineee, 1989, I.Iivat, 1985).

Iaeiae aeine?aeaeaiiyie, i?iaaaeaieie ni?a?ia?oieeaie oeiee Ai?eciioiaa
(I.Ae.Ai?eciioia, 1981; I.Ae.Ai?eciioia n niaao., 1983), aoei
anoaiiaeaii, ui iaeo?io?eueiee eaeeioeeoic, iaoiiaeaiee aeoeaaoe??th
a?aioeioeeoiiiaco, ?icaeaa?oueny ? i?e ae?? ia i?aai?ci no?ani??a
ia?ioaeoe?eii? i?e?iaee, ui aei oeueiai /ano ia iaea?aeaei iiyniaiiy.

?aaeoe?y iaeo?io?eueieo eaeeioeeo?a ia ae?th no?ani??a ia?ioaeoe?eii?
i?e?iaee aoea anoaiiaeaia I.A.Eoi?iith ? I.I.Eictheii (1978), ye?
iieacaee, ui i?e aino??e e?iaiao?ao? ?icaeaa?oueny iaeo?io?eueiee
eaeeioeeoic, ui noi?iaiaeaeo?oueny ciaioaiiyi /enea e?cinii ? a?aioe
e?ciniiaeueieo eao?iiieo a?ee?a o iaeo?io?eueieo eaeeioeeoao
ia?eoa?e/ii? e?ia?. ?iaioaie, i?iaaaeaieie a iao?e eaai?aoi???, aoei
aeiaaaeaii, ui ca?eueiaiiy e?ciniiaeueieo oa?iaio?a c iaeo?io?eueieo
eaeeioeeo?a a?aeaoaa?oueny oeyoii aecioeeoico, aac ii?ooaiue oe?e?niino?
iaia?ai ee?oeie (N.A.Eiaaeue n niaao., 1983). O aeine?aeao in vitro
anoaiiaeaii, ui e?ciniiaeuei? oa?iaioe iaeo?io?e?a, ia/?iee, aieiaiiai
iiceo caeaoi? aeoeaoaaoe oaeoi? Oaaaiaia. I?e/iio oey aeanoea?noue a
cia/ii a?eueo?e i??? i?eoaiaiia e?ciniiaeueiei oa?iaioai naia
iaeo?io?e?a (I.A.Eoieia, N.A.Eiaaeue, 1983).

Iiaeaeueo? aeine?aeaeaiiy e?ciniiaeueiiai aia?aoo iaeo?io?eueieo
eaeeioeeo?a i?e ae?? no?ani??a ia?ioaeoe?eii? i?e?iaee aeicaieeee
anoaiiaeoe, ui e?ciniiaeuei? oa?iaioe ? eao?iii? a?eee, iio?aieyth/e a
e?ia, aeoeaothoue Oaaaiai-caeaaei? i?ioeane cai?oaiiy, o?a?eiie?co,
eaeee?a?i-eei?iiao nenoaio ? nenoaio eiiieaiaioo (I.A.Eoi?ia,
N.A.Eiaaeue, 1982, 1983; N.A.Eiaaeue n niaao., 1983; A.A.Ne?eiea, 1983,
1986, 1990; N.E.Oeiea?aa, 1983; I.A.Eoieia, A.O.Iieoaaneee, 1984;
I.A.Aaaoiiiaa, I.A.Eoieia, 1987; I.A.Eoieia, N.A.Aiae, 1992, 1993;
I.A.Eoieia, N.A.Aiae, A.A.*aoia, 1993; A.A.*aoia, N.A.Aiae, 1993). I?e
oeueiio aeoeaaoe?y e?ciniiaeueiiai aia?aoo i?e aieea? e?iaiao?aoe
(I.A.Eoieia, I.I.Eicthe, 1978; A.A.Ne?eiea, 1983, 1990), cieaeaiiai
aa?iiao?e/iiai oeneo (I.A.Eoi?ia, A.O.Iieaoanueeee, 1984), aaa?oiino? ?
?iae?a (I.A.Eoieia, N.A.Eiaaeue, 1982, 1983; N.A.Eiaaeue n niaao.,
1983), ?iiia?e?caoe?y (I.A.Eoieia, I.A.Aaaoiiiaa,1986; E.A.Eiaoo, 1988;
I.A.Eoieia, E.A.Aaaeoiiaa, 1990, 1991; I.A.Eoieia, A.A.*aoia, 1992;
A.A.*aoia, N.A.Aiae,1993) aoea caeaaeia a?ae neee iiae?acithth/iai
oaeoi?a (I.A.Aaaoiiiaa, I.A.Eoieia, 1987) ? ?icaeaaeanue i?ae eiio?ieai
neiiaoe/ii? ia?aiai? nenoaie (N.A.Aiae, 1993) oa
a?iioaeaii-a?iio?ca?ii-aae?aiiei?oeeaeueii? nenoaie (A.A.*aoia,
N.A.Aiae, 1993). Ia i?aenoaa? oeueiai aoei c?iaeaii aeniiaie i?i
ianiaoeeo?/i?noue ?aaeoe?e e?ciniiaeueiiai aia?aoo iaeo?io?eueieo
eaeeioeeo?a, ui caaacia/othoue caa?aaeaiiy aiiainoaco a oiiaao no?ano.

Anoaiiaeaii, ui i?e ae?? ia i?aai?ci iaaecae/aeieo iiae?aciee?a a
aenia?eiaio? ?iiae? ii?oooaaany aaiinoac, ui ae?aaeaany a
?icocaiaeaeaii? ooieoe?iiaeueii? aeoeaiino? nenoai, caeaaeieo a?ae
oaeoi?a Oaaaiaia — a oiio /ene? cai?oath/i? oa o?a?eiie?oe/ii?, ? oae?
oaa?eie cae/aeii aeioee (I.A.Aaaoiiiaa, I.A.Eoi?ia, 1987; I.A.Eoi?ia,
E.A.Aaaeoiiaa, 1990, 1991). A naith /a?ao a?aeiii, ui ?icoaiaeaeai?noue
nenoai ?aaoethaaiiy aa?aaaoiiai noaio e?ia? iiaea i?eaanoe aei ?icaeoeo
neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai cn?aeaiiy e?ia?
(AeAC-neiae?iio) (I.A. Ai?aoiiaa, 1981; I.ss.Eaaooeia, 1981).

?acoeueoaoe aenia?eiaio?a aeicaieeee aenoiooe i?eiouaiiy, ui, iiaeeeai,
e?ciniiaeuei? oa?iaioe iaeo?io?eueieo eaeeioeeo?a iiaeooue aieeaaoe ia
?icaeoie AeAC-neiae?iio.

Oei a?eueoa, ui, ca?aeii c no/anieie oyaeaiiyie, eaeeioeeoe, a oiio
/ene? e iaeo?io?ee, a?ae?a?athoue aaeeeo ?ieue o i?aeo?eiaii? aaiinoaco,
i?noyoue ??ciiiai?oi? oaeoi?e, ui ni?eythoue ? ia?aoeiaeaeathoue
cai?oaiith e?ia?, cie?aia, o?iiaiieanoe/iee oaeoi?, aioeaaia?eiiaee
oaeoi?, aaia?ei, aioeeiaaoeyio aioeo?iiaiieanoe/ii? ae??, ieaci?i,
ieaci?iiaai ? i?iaeoeaaoi?e ieaci?iiaaia, o?e o?aeoe?? aioeieaci?io
(A.E.Eociee n niaao., 1974; A.E.Eociee, ss.Ae.E?anee, 1979; A.E.Eociee,
1990; A.E.A?eoethe, 1994). Iaeiae aeine?aeaeaiiy eaeeioeeoa?iiai
eiiiiiaioa aaiinoaco ua ia iaea?aeaee aeinoaoiuei? ? iaeaaeii? ia eeoa
i?aeoe/ii?, aea e iaoeiai? ai?iaaoe??.

Aeoiaey/e c aeeeaaeaiiai aeua, iaie aoee iinoaaeai? oae? iaoa ?
caaaeaiiy aeine?aeaeaiiy.

Iaoa ? caaaeaiiy aeine?aeaeaiiy

C’ynoaaoe ?ieue e?ciniiaeueieo oa?iaio?a iaeo?io?eueieo eaeeioeeo?a o
?icaeoeo neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai cai?oaiiy
e?ia?.

O caaaeaiiy ?iaioe aoiaeeei:

1) aea/eoe i?e iiaeaethaaii? aenia?eiaioaeueiiai AeAC-neiae?iio
e?euee?ni? ci?ie iaeo?io?e?a o ia?eoa?e/i?e e?ia?;

2) aea/eoe noai a?aioeioeeoiiiaco;

3) aea/eoe aaeaaceai? aeanoeaino? eaeeioeeo?a;

4) aea/eoe ii?oiooieoe?iiaeuei? aeanoeaino? e?ciniiaeueiiai aia?aoo
iaeo?io?eioeeo?a ca ai?noii e?cinii ? a?aioe e?ciniiaeueieo eao?iiieo
a?ee?a o iaeo?io?eao ? aeoeai?noth ia?ea?iiai e?ciniiaeueiiai oa?iaioa
iaeo?io?e?a — eenei? oinoaoace o ne?iaaooe? e?ia?;

5) aeine?aeeoe noai aaiinoaco ca /anii ?aeaeueoeeo?eaoe?? ieacie,
o?iia?iiaei /anii, e?euee?noth o?a?eiiaaio, aeoeai?noth OO oaeoi?a,
aoaiieiaei oanoii ? oanoii ia i?iaeoeoe aeaa?aaeaoe??
o?a?eio/o?a?eiiaaio (IAeO); 6) i?iaanoe ii?oieia?/ia aeine?aeaeaiiy oa
aiae?c aeayeeo aioo??oi?o i?aai?a(eaaaiue, ie?ie, iaaeie?eiaeo caeic,
ia/?iee).

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa aeiaaaeaia caeaaei?noue oi?ioaaiiy AeAC-neiae?iio a?ae
ooieoe?iiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a. Ia iniia?
iaea?aeaieo aenia?eiaioaeueieo aeaieo aenoiooi iieiaeaiiy i?i oa, ui i?e
oi?ioaaii? AeAC-neiae?iio e?ciniiaeuei? oa?iaioe iaeo?io?eueieo
eaeeioeeo?a aa?ooue o/anoue o ii?ooaii? aaiinoaco. Cie?aia, anoaiiaeaii,
ui na?e aieea ia ii?ooaiiy aaiinoaco e?ciniiaeuei? oa?iaioe
iaeo?io?eueieo eaeeioeeo?a aeyaeythoue a oiiaao ??cei ae?aaeaii?
eaeeioeeoa?ii? ?aaeoe?? ? aecia/athoue ?icaeoie a?iieiaaoeyoe?eiiai
noaio, yeee aeyaey?oueny ??ceei aeniaaeaiiyi oaeoi??a cai?oaiiy e?ia?,
aae aei iiaiiai ?? iacai?oaiiy, oa aeoeaaoe??th oaeoi??a o?a?eiie?oe/ii?
nenoaie. Oaea ni?aa?aeiioaiiy aeoeaiino? cai?oath/i? oa o?a?eiie?oe/ii?
nenoai ? aecia/eei i?iya AeAC-neiae?iio.

A oeeo oiiaao niinoa??aaeanue cai?ioia ei?aeyoeaia caeaaei?noue i?ae
aeoeai?noth e?ciniiaeueieo oa?iaio?a ? noaiii oaeoi??a cai?oath/i?
nenoaie e?ia? oa i?yia — c oaeoi?aie o?a?eiie?oe/ii? nenoaie.

Iaaaaeaia caeaaei?noue noaio aaiinoaco a?ae ooieoe?iiaeueii? aeoeaiino?
e?ciniiaeueiiai aia?aoo iaeo?io?eioeeo?a anoaiiaeaia a aenia?eiaioao c
i?eai?/aiiyi a?aioeioeeoiiiaco, ui aeeeeeaei cia/ia cieaeaiiy a e?ia?
ai?noo e?ciniiaeueieo oa?iaio?a iaeo?io?eueieo eaeeioeeo?a.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

?acoeueoaoe aeine?aeaeaiue iathoue iaaia oai?aoe/ia cia/aiiy, iine?eueee
?icoe?ththoue ?nioth/? oyaeaiiy i?i cia/aiiy iaeo?io?eueiiai
eaeeioeeoico ? iiaeooue neoaeeoe aeey iiaeaeueoi? ?ic?iaee i?iaeaie ii
eaeeioeeoa?iiio eiiiiiaioo aaiinoaco. Cie?aia, iieacaia o/anoue naia
e?ciniiaeueieo oa?iaio?a oee?eoethth/eo iaeo?io?e?a o ci?iao cai?oath/i?
oa o?a?eiie?oe/ii? nenoai i?e AeAC-neiae?ii?.

I?aeoe/ia oe?ii?noue ?iaioe iieyaa? a oiio, ui anoaiiaeai? ei?aeyoe?ei?
ca’ycee i?ae aeoeaaoe??th e?ciniiaeueiiai aia?aoo iaeo?io?eueieo
eaeeioeeo?a ? nenoaiaie e?ia? — cai?oath/ith ? o?a?eiie?oe/iith —
iiaeooue aooe aeei?enoai? aeey iiyniaiiy ? ei?aeoe?? ii?ooaiue aaiinoaco
i?e AeAC-neiae?ii?. ?aaoethaaiiy eiioeaio?aoe?? e?ciniiaeueieo oa?iaio?a
iaeo?io?e?a o e?ia? iiaea caiia?aoe ?icaeoeo aeeaieeo a?iieiaaoeai?/ieo
c?ooaiue aaiinoaco a oiae? ?icaeoeo neiae?iio AeAC.

Iniaenoee aianie i?aoaiaeaioa

An? aenia?eiaioaeuei? aeai? ii oai? aeena?oaoe?? aeeiiai?
aaciina?aaeiuei aeena?oaioii. Ui noino?oueny ni?aaaoi??a, c yeeie aoee
iioae?eiaai? i?aoe?, oi ?acoeueoaoe ?o aeine?aeaeaiue aoee aeei?enoai?
aeey i?aeoaa?aeaeaiiy iaea?aeaieo ?acoeueoao?a, ?o iaa?oiooaaiiy, oae ye
ni?a?ia?oieee iaoi? eaai?aoi??? i?aoeththoue i?ioyaii 15 ?ie?a ii oai?
“?ieue e?ciniiaeueieo oa?iaio?a iaeo?io?eueieo eaeeioeeo?a o oi?ioaaii?
no?an-neiae?iio”. A oeueiio ?icoi?ii? oey aeena?oaoe?eia i?aoey ?
i?iaeiaaeaiiyi aeine?aeaeaiue ii caaaeuei?e i?iaeai?.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

I?i ?acoeueoaoe aeena?oaoe?eii? i?aoe? aeiiia?aeaeinue ia ui??/ieo
iaoeiaeo eiioa?aioe?yo Eoaainueeiai iaaeaaia?/iiai ?inoeoooo a 1996-1998
??., ia XV c’?cae? Oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa
(Aeiiaoeuee,1998),ia i?aeia?iaei?e eiioa?aioe?? “A?iien?y: aeano?oeoeaia
oa eiino?oeoeaia ae?y” (Ee?a, 1998).

Ioae?eaoe??

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 6 i?aoeue, c yeeo 4 aeo?iaeuei?
noaoo? ? 2 i?aoe? a oacao.

No?oeoo?a oa ianya aeena?oaoe??

Aeena?oaoe?y neeaaea?oueny c anooio, 5 aeaa, iaaiai?aiiy iaea?aeaieo
?acoeueoao?a, aeniiaeo, nieneo e?oa?aoo?e.

Aeena?oaoe?y iaienaia ia 120 noi??ieao, c ieo aeaniiai oaenoo 85
noi??iie, aeeth/ath/e 27 oaaeeoeue ? 40 iaethie?a, ye? caeiathoue 35
noi??iie. Iieaciee e?oa?aoo?e i?noeoue 250 a?o/eciyieo ? ca?oa?aeieo
aeaea?ae.

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

Aeine?aeaeaiiy iinoaaeai? ia 80 aacii?iaeieo e?ieeeao iaio noaoae ianith
2,5-3,0 ea.

Aenia?eiaioaeuei? oaa?eie aoee ?icae?eai? ia 2 a?oie:

? a?oia — eiio?ieueia,

II a?oia — aeine?aeia.

O e?ieee?a iaio a?oi a?aeoai?thaaany AeAC-neiae?ii. O II a?oi?
aeine?aeaeaiue AeAC-neiae?ii iiaeaethaaee a oiiaao i?eai?/aiiy
a?aioeioeeoiiiaco.

AeAC-neiae?ii iiaeaethaaee i?aia?aoii “Aoa-2” (“Aeaeaia — AEI”, Iineaa),
aeaioiaeaiei ia iniia? io?ooe ci?? aoe aaaaoieoneaoi? (Ehis
multisguamatus). A?aeiii, ui io?ooa ci?? aoe ia? eiaaoethth/?
aeanoeaino? ? i?e ?? iaaeoiaeaeaii? a i?aai?ci ?icaeaa?oueny iaeia c
oi?i AeAC-neiae?iio (C. N. Aa?eaaai, 1985, 1988).

Aeey a?aeoai?aiiy iiaeae? AeAC-neiae?iio aeei?enoiaoaaee ??ci? aeice
i?aia?aoo “Aoa-2”. Aeey aea/aiiy an?o oac AeAC-neiae?iio iaea?eueo
i?eeiyoiith ? i?aeaino?a oi?ia i?io?eaiiy, yea ?icaeaa?oueny i?e
aaaaeaii? i?aia?aoo “Aoa-2” iauana?oea ia?i?aeueii a aeic? 8350 ia/ea.

I?eai?/aiiy a?aioeioeeoiiiaco cae?enithaaeinue oeyoii ia?i?aeueiiai
aaaaeaiiy i??einaio (AI “Ieoya?ue”, Naieo-Iaoa?ao?a) a aeicao: 10 ia ia
aeiao i?ioyaii 5-7 aei?a — aei ciaioaiiy aaniethoiiai /enea iaeo?io?e?a
o e?o?? e?ia? ia 40-50 % ? 4 ia ia aeiao a na?aaeiueiio i?ioyaii 8
aei?a. Iae?ath/e oae? aeice i??einaio, ie ea?oaaeeny aeac?aeaie O. I.
*aioeiai?, I. O. Eeeiiai? (1967), ye? aaiaeeee i?aia?ao i??eia?iiie, ui
i?eai?/o? a?aioeioeeoiiiac ? a cacia/aieo aeicao cieaeo? e?euee?noue
eaeeioeeo?a oaeiae ia 40 — 50 %.

O e?ieee?a ? a?oie aeine?aeaeoaai? iieacieee aea/aeenue o ?ioaeoieo
oaa?ei ? i?ney aaaaeaiiy “Aoa-2” aei a?aeiiaeaiiy iieaciee?a cai?oath/i?
nenoaie aei aeo?aeiiai ??aiy. A ?? a?oi? iieacieee aea/aeenue o
?ioaeoieo oaa?ei i?ney i?eai?/aiiy a?aioeioeeoiiiaco ? i?ney aaaaeaiiy
i?aia?aoo “Aoa-2” aei a?aeiiaeaiiy cai?oath/i? nenoaie.

A on?o oaa?ei aeine?aeaeoaaeenue iieacieee, ui oa?aeoa?ecothoue
ooieoe?iiaeueiee noai e?ciniiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a
? aaiinoac, ? i?iaiaeeeinue ii?oieia?/ia aeine?aeaeaiiy eaaaiue, ie?ie,
iaaeie?eiaeo caeic, ia/?iee.

Caaaeueia e?euee?noue eaeeioeeo?a, ai?no iaeo?io?e?a, a?aioeioeeoiiiac
aeine?aeaeoaaee caaaeueiii?eeiyoeie iaoiaeeeaie (A.A.Iaiueoeeia, 1987).

E?ciniiaeueii-eao?iiio oi?ioeo iaeo?io?e?a ia?eoa??eii? e?ia? aea/aee ca
iaoiaeii A.A.Ieaa?aanueeiai (1978). I?ae?aoiaoaaee e?ciniie ? a?aioee
e?ciniiaeueieo eao?iiieo a?ee?a, aeei?enoiaoth/e na?oeiaee i?e?ineii
(i?e ca?eueoaii? ie.15, ia.90).

Aeey aea/aiiy ai?noo e?cinii o iaeo?io?eueieo eaeeioeeoao iacee e?ia?
oa?aoaaee aa?aieeii Iae-A?thiaaeueaea. I?e i?e?ineiioaaii? e?ciniie
aeeoa?aioe?ththoueny ye e?oii? ie?oae? o?eueoey ?iaeaaiai eieuei?o.

I?e aeine?aeaeaii? e?eueeino? a?aioe e?ciniiaeueieo eao?iiieo a?ee?a
iaeo?io?e?a e?ia? aeei?enoiaoaaee aa?aiee “na?oeiaee caeaiee”
(I.A.Eoi?ia, N.A.Eiaaeue 1982). A?aioee e?ciniiaeueieo eao?iiieo a?ee?a
o na?oeiaee i?e?ineii aecia/athoueny ye yne?aai-caeai? ie?oae?
ooai?aiiy.

I?ae?aoiaoaaee 100 iaeo?io?e?a oa ?aeaioeo?eoaaee na?aae ieo 3 a?oie:

1 — iaeo?io?ee, ui i?noyoue iiiaae 30 e?cinii ? a?aioe eao?iiieo a?ee?a,

2 — iaeo?io?ee, ui i?noyoue a?ae 29 aei 10 e?cinii ? a?aioe eao?iiieo
a?ee?a,

3 — iaeo?io?ee, ui i?noyoue iaioa 10 e?cinii ? a?aioe eao?iiieo a?ee?a.

?acoeueoao ae?aaeaee a i?ioeaioao. Ca i?ioeaioiei ai?noii iaeo?io?eueieo
eaeeioeeo?a eiaeii? c 3-o a?oi ? caaaeueiith e?euee?noth iaeo?io?e?a o
e?ia? ae?aoiaoaaee aaniethoiee ai?no aeaa?aioeueiaaieo iaeo?io?e?a (a
iaeeieoeyo NE — O 109/e).

Aeoeai?noue ia?ea?iiai e?ciniiaeueiiai oa?iaioa — eenei? oinoaoace a
ne?iaaooe? e?ia? aea/aee ca iaoiaeii Aiaeainueeiai (A.A.Iie?ianeee,
1969).

Aaiinoac i?e AeAC-neiae?ii? ioe?ithaaee ca oi?o?eiaaiei /anii
?aeaeueoeeo?eaoe?? ieacie, ca o?iia?iiaei /anii, ca ai?noii o?a?eiiaaio,
ca aeoeai?noth oaeoi?a OIII, ca ia?aeiaaoeyoe?eieie oanoaie
(A.I.Aaeoaea, 1980; A.A.Iaiueoeeia, 1987).

Ii?oieia?/ia aeine?aeaeaiiy i?aai?a i?iaaaeaii o 20 e?ieee?a — ii 10 o
eiaei?e a?oi?. Oaa?ei caaeaaee a ia??iae iaeneiaeueii? aeoeaiino?
ia?ea?iiai e?ciniiaeueiiai oa?iaioa — eenei? oinoaoace. I?e
a?noieia?/iiio aeine?aeaeaii? caa?oaee oaaao ia iayai?noue o?iia?a oa
aa?aaao?a oi?iaieo aeaiaio?a e?ia? o noaeeiao i?e?ioee?eoeyoi?iiai
?onea, aaii?aa?e ? iae?ic?a o aioo??oi?o i?aaiao.

?acoeueoaoe aenia?eiaio?a ii?aoeueiaai? noaoenoe/ii iaoiaeii i?yieo
??cieoeue, ye iienaii o A.A.Iiioeaa?/ooa-A??iaaia (1964). Ae/eneyee
na?aaei? ??cieoe? oa ?o iioeaee, aeinoia??i? a?aei?iiino?. Noaoenoe/ia
ii?aoethaaiiy cae?enithaaee ia eiii’thoa??.

?acoeueoaoe oa ?o iaaiai?aiiy

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue anoaiiaeaii, ui o e?ieee?a ?
a?oie i?ney aaaaeaiiy i?aia?aoo “Aoa-2” ?icaeaaany iaeo?io?eueiee
eaeeioeeoic c iaeneiaeueiei ca?eueoaiiyi iaeo?io?eueieo eaeeioeeo?a ia
10-11 aeiao aenia?eiaioo (+3.7±0.71; ?<0.001). Ca aeaieie e?oa?aoo?e, iaeo?io?eueic iiaea aooe iaoiiaeaiee ye ia?a?iciiae?eii iaeo?io?e?a c ia?aeiaeueiiai ioea, ui i?noeoue aei 50-60% iaeo?io?e?a, o oee?eoeyoe?th (A.I.Iayineee, Ae.A.Iayinueeee, 1989; A.Ae.Aieueaeaa?a n niaao., 1991), oae ? aeoeaaoe??th i??ei?aeiiai e?iaioai?aiiy (I.Ae. Ai?eciioia n niaao., 1983, A.Ae.Aieueaeaa?a n niaao., 1991, R. Webber e.a., 1970). A iaoiio aeine?aeaeaii? /a?ac aeiao i?ney aaaaeaiiy “Aoa-2” o e?noeiaiio iiceo e?ieee?a niinoa??aaeanue ??cea aeoeaaoe?y a?aioeioeeoiiiaco (+76.8±1.64;?<0.001) c i?enei?aiiyi i?ioean?a aec??aaiiy, ui i?aeo?eioaaei ca?eueoaio e?euee?noue iaeo?io?e?a i?aeoe/ii i?ioyaii anueiai ia??iaeo aenia?eiaioo. Aiaeia?/i? ?acoeueoaoe i?e aea/aii? ae?? ??cieo no?ani??a ia?ioaeoe?eii? i?e?iaee aoee iaea?aeai? e ?ioeie aaoi?aie (A.I.Aeuaae, A.I.Oaoia, 1989; A.Ae.Aieueaeaa?a n niaao., 1990, 1991; I.A.Eoieia, E.A.Aaaeoiiaa, 1991; I.A.Eoieia, N.A.Aiae, 1992, 1993; A.A.*aoia, 1993), i?ioa ae?y i?aia?aoo “Aoa-2” aeacaiieie aeua aaoi?aie ia aea/aeanue. ?acoeueoaoe aeine?aeaeaiue na?ae/aoue, ui iaeo?io?eueic o oaa?ei noi?iaiaeaeoaaany ci?iith ooieoe?iiaeueiiai noaio e?ciniiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a. Anoaiiaeaii ciaioaiiy /enea e?cinii ? a?aioe e?ciniiaeueieo eao?iiieo a?ee?a o iaeo?io?eao i?ney aaaaeaiiy “Aoa-2”, iaeneiaeueii ae?aaeaia ia 10-11 aeiao aeine?aeo(+6.0±0.48; ?<0.001). Iaea?eueo cia/ia aeaa?aioeyoe?y ? aeaeao?ii?caoe?y iaeo?io?eueieo eaeeioeeo?a a?aeiia?aeaea no?ieai ?icaeoeo iaea?eueo ae?aaeaiiai iaeo?io?eueico. Iaeneiaeueiee ??aaiue aeoeaiino? ia?ea?iiai e?ciniiaeueiiai oa?iaioa — eenei? oinoaoace a ne?iaaooe? e?ia? a?aecia/aany ia 10-11 aeiao aeine?aeo (+0.84±0.18; ?<0.001), ui a?aeiia?aeaei iaea?eueo aenieiio aaniethoiiio ai?noo aeaa?aioeueiaaieo iaeo?io?e?a. A?aeiii, ui i?aeaeuaiiy aeoeaiino? e?ciniiaeueieo oa?iaio?a o ne?iaaooe? e?ia? ? ianiaoeeo?/iith ?aaeoe??th i?aai?cio, ui ?icaeaa?oueny o a?aeiia?aeue ia aieea iiae?acieea aeinoaoiuei? neee (N.A.Oeueyiaiei, I.I.No?eiia, 1982; I.E.Aaoia, 1988; I.O.Ei?iaeei, 1989; K.Kramer e.a., 1987). I?e oeueiio i?aeaeuo?oueny i?iieeeea?noue e?ciniiaeueieo iaia?ai ? a?aeaoaa?oueny aea?eueiaiiy a?ae?ie?oe/ieo oa?iaio?a e?cinii (E.A.Iaiei, 1983; E.A.Iaiei, I.I.Iayineay, 1987). Ca?eueoaiiy i?iieeeeaino? e?ciniiaeueieo iaia?ai ? i?aeaeuaiiy aeoeaiino? e?ciniiaeueieo oa?iaio?a o e?ia? anoaiiaeaii i?e aaii?aa?/iiio oieo (S.Harpacsy, G.Shells, 1980) oa a?iien?? (E.E.Aioiiiaa, 1993; D.Acosta e.a., 1978). E??i oiai, i?aoe?aieeaie iaoi? eaai?aoi??? aoei oaeiae iieacaii i?aeaeuaiiy i?iieeeeaino? e?ciniiaeueieo iaia?ai iaeo?io?e?a, ui noi?iaiaeaeo?oueny ca?eueoaiiyi aeoeaiino? e?ciniiaeueieo oa?iaio?a o e?ia? a oiiaao ae?? no?ani??a ?ioaeoe?eii? ? ia?ioaeoe?eii? i?e?iaee (A.O.Iieoaaneee, 1985; I.A.Aaaoiiiaa, I.A.Eoieia, 1987; I.A.Caeaiueei, 1993). Iaaeoiaeaeaiiy e?ciniiaeueieo oa?iaio?a o iicaee?oeiiee i?ino?? iiaea a?aeaoaaoenue ??cieie niiniaaie. A iaeieo aeiaaeeao aeo?ae oa?iaio?a e?cinii noi?iaiaeaeo?oueny iioeiaeaeaiiyi ieaciaoe/ii? ? e?ciniiaeueii? iaia?ai (A.A.O?ieia, 1986; G.Weissman, 1976; D.E.Chaudler, 1980), a ?ioeo aeiaaeeao — /a?ac oaainiio, ui iaiiai?noth cae?eeany ?c ciai?oiueiai aieo ee?oeie (aiaeioeeoic), aai i?e aaciina?aaeiueiio aeae?eaii? ai?noo aco?io?eueieo a?aioe (aecioeeoic) i?ney ia?ai?uaiiy ?o aei ieaciaeaie (Ae.E.Iiaeeia, 1987; I.E.Aaoia n niaao., 1988; A.I.Iayineee, Ae.I.Iayineee, 1989; J.E. Beesley e.a. 1988). N.A.Eiaaeue c ni?aaaoi?aie (1983) anoaiiaeee, ui cieaeaiiy /enea e?cinii ? a?aioe e?ciniiaeueieo eao?iiieo a?ee?a o iaeo?io?eioeeoao iaoiiaeaii aeoiaeii e?ciniiaeueiiai ai?noo a e?ia oeyoii aecioeeoico. Oea ia i?yii i?aeoaa?aeaeo?oueny iaoeie aeine?aeaeaiiyie, ye? iieacaee caa?aaeaiiy a oee?eoeyoe?? iiai?noth aeaa?aioeueiaaieo ? aeaeao?ii?ciaaieo iaeo?io?e?a i?e ca?eueoaii? caaaeueiiai ai?noo iaeo?io?eueieo eaeeioeeo?a o ia?eoa??ei?e e?ia?. I?ney aaaaeaiiy “Aoa-2” ca?eueooaaeenue aa?aaaoe?ei? aeanoeaino? eaeeioeeo?a o e?ia?, ui ae?aaeaeinue o i?aeaeuaii? iieacieea aa?aaaoe?? eaeeioeeo?a (IAE) oa ?iaeaeno aa?aaaoe?? eaeeioeeo?a (?AE) i?ioyaii anueiai ia??iaeo aeine?aeaeaiiy (e??i 10-12-? aeiae, eiee cia/aiiy iieacieea aoee ieae/a aeo?aeieo aaee/ei). Iaeneiaeueia ae?aaeai?noue eaeea?a?/ieo aeanoeainoae eaeeioeeo?a ?a?no?oaaeanue ia 2-4-oo aeiao (+9.5±1.52;?<0.001), a ia??iae a?ia?eiaaoeyoe?eieo ci?i aaiinoaco, a i?i?iaeueia — ia 10-12-oo aeiao(-2.0±0.68;?,0.01), a ia??iae aeeaieeo a?iieiaaoeyoe?eieo ii?ooaiue aaiinoaco ? iaeneiaeueii? aeoeaiino? e?ciniiaeueieo oa?iaio?a o ne?iaaooe? e?ia?. Iaeiae inoaii? ia a?aeiia?aea? aeaiei e?oa?aoo?e, aea aeaco?oueny ia oa, ui i?aeaeuaiiy aaeaaceaiino? iaeo?io?eueieo eaeeioeeo?a noi?iaiaeaeo?oueny aeae?eaiiyi e?ciniiaeueieo oa?iaio?a iaeo?io?e?a, ye?, a naith /a?ao, aeeiiothoue ?ieue aa?aaaoe?eiiai oaeoi?a (E.Ae?anea?, 1988; ?.Wautier, 1983; D.Tsvetkov, 1987). Ii?ooaiiy aa?aaaoe?eieo aeanoeainoae eaeeioeeo?a iiaeia iiynieoe iine?aeiaiith aa?aaaoe??th ? aeacaa?aaaoe??th, a ?acoeueoao? /iai eaeeioeeoe noathoue iaio ooieoe?iiaeueii iiaiioe?iieie ? neaae?oa ?aaaothoue ia iiaoi?iee aieea aa?aaoth/eo aaaio?a, ui iia’ycaia c ae?aaeaiith a oeae ia??iae aeaa?aioeyoe??th iaeo?io?e?a. E??i oiai, ia ciaioaiiy nooiaiy aa?aaaoe?? ee?oei e?ia? iiaea aieeaaoe ca?eueoaiee ai?no i?iaeoeo?a aeaa?aaeaoe?? o?a?eio/o?a?eiiaaio (IAeO), ye? ae?thoue ye aioeaa?aaaoe (A.I.Ae?aiiee, 1987; E.I.Aiea?aa n niaao., 1989). Aaaaeaiiy “Aoa-2” i?ecaiaeeei aei ci?i iieaciee?a aaiinoaco. A ia?o? /ioe?e aeiae a?aecia/aeinue ??cea oei?i/aiiy /ano ?aeaeueoeeo?eaoe?? ieacie (-40.9±4.20;?<0.001) ? o?iia?iiaiai /ano (-5.6±0.58;?<0.001), i?aeaeuaiiy ai?noo o?a?eiiaaio(+31.7±8.54;?<0.01) ? aeoeaiino? OO oaeoi?a(+72.0±3.85;?<0.001). Aecia/aeenue iiceoeai? i?iae aoaiieiaiai oanoo ? ia IAeO. Iiae?ai? ci?ie cai?oath/i? nenoaie na?ae/aoue i?i a?ia?eiaaoeyoe?ei? ii?ooaiiy aaiinoaco (N.A.Eaaeoeeay, 1984; E.Eaeye, 1991; A.E.A?eoethe, 1994). Ui ae noino?oueny ci?i aoaiieiaiai oanoo ? i?iae ia IAeO, oi, ca aeaieie e?oa?aoo?e, a?aeiii, ui iiceoeaia i?iaa aoaiieiaiai oanoo aeaco? ia iayai?noue o ieaci? eiiieaen?a o?a?ei-iiiiia?o c o?a?eiiaaiii ? ?aii?ie IAeO, ? i?enooi?noue o ne?iaaooe? e?ia? IAeO ?icaeyaea?oueny ye aaaeeeaee e?eoa??e AeAC-neiae?iio (A.I.Ae?aiiee, 1988; A.A.Iaiueoeeia, 1989; R.L.Bick, 1982). A ianooii? aei? aeoeai?noue oaeoi??a cai?oaiiy e?ia? ii/eia? iinooiiai cieaeoaaoeny:/an ?aeaeueoeeo?eaoe?? ieacie a 2.2 ?ace, o?iia?iiaee /an a 1.6 ?aca, ai?no o?a?eiiaaio a 2.8 ?aca, aeoeai?noue O??? oaeoi?a a 1.8 ?aca. O ieaci? e?ia? aecia/athoueny o?a?ei-iiiiia?i? eiiieaene, a a ne?iaaooe? e?ia? noa? ua aeuei ??aaiue IAeO. Iaea?aeai? ?acoeueoaoe aeyaeythoue ia?ao?aeio noaae?th eiaaoeiiao?? niiaeeaaiiy (I.N.Ia/aaaee, 1981; C.N.Aa?eaaai, 1988; P.Seveik, 1991). Ii/eiath/e c 9-? aeiae aenia?eiaioo, nenoaia aaiinoaco oa?aeoa?eco?oueny oneeaaeiaiiyi eiaaoeiiao?? niiaeeaaiiy c ??ceeie iciaeaie a?iieiaaoeyoe??: ??cei ca?eueoaiee /an ?aeaeueoeeo?eaoe?? ieacie (+206.7±16.91;?<0.001) ? o?iia?iiaee /an (+15.6±2.42;?<0.001), iaeneiaeueii ae?aaeaia o?a?eiiaaiiiai?y (-52.6±6.25;?<0.001), cia/ii cieaeaia aeoeai?noue OO oaeoi?a (-76.7±3.52;?<0.001), ui ua ?ac i?aeoaa?aeaeo? ?icaeoie a?iieiaaoeai?/ieo ii?ooaiue. I?iae aoaiieiaiai oanoo a ieaci? noathoue iaaaoeaieie, a a ne?iaaooe? e?ia? i?aeaeuo?oueny ai?no IAeO. Iayai?noue iaaaoeaieo i?ia aoaiieiaiai oanoo a ieaci? e?ia? iiaeia iiynieoe aenieei ??aiai ai?noo i?iaeoeo?a aeaa?aaeaoe?? o?a?eio/o?a?eiiaaio, ye? ? ?iaea?oi?ii iie?ia?ecaoe?? o?a?ei-iiiiia??a (E.A.Iieuineay, 1985; A.I.Ae?aiiee, 1987; V.A.Belitser at al., 1982; R.L.Bick, 1982). Oaeei /eiii, aiae?coth/e iaea?aeai? aeai?, iiaeia c?iaeoe aeniiaie, ui i?ney aaaaeaiiy “Aoa-2” o oaa?ei niinoa??aaeenue aeeaie? ii?ooaiiy aaiinoaco, ye? ae?aaeaeenue ?icaeoeii noaae?e, ui iine?aeiaii ci?ithaaee iaeia ?ioo: a?ia?eiaaoeyoe?eii?, i?e ye?e niinoa??aaeanue ??cea aeoeaaoe?y oaeoi??a cai?oath/i? nenoaie ? aa?aaaoe?y ee?oei; eiaaoeiiao?? niiaeeaaiiy, i?e ye?e a?aeaoaaeinue iinooiiaa aeniaaeaiiy oaeoi??a cai?oaiiy oa aeoeaaoe?y o?a?eiie?co; a?iieiaaoeyoe?eii?, yea oa?aeoa?ecoaaeanue ??ceei ca?eueoaiiyi /ano cai?oaiiy e?ia?, aae aei iiaii? ao?aoe iath aeanoeainoae cai?oaoeny, iaeneiaeueiei ciaioaiiyi ai?noo o?a?eiiaaio ? i?aeaeuaiiyi ??aiy IAeO, ui aeaco? ia ?icaeoie neiae?iio AeAC. I?e ni?anoaaeaii? aeaieo aeoeaiino? ia?ea?iiai e?ciniiaeueiiai oa?iaioa — eenei? oinoaoace i?ioyaii aenia?eiaioo ? ci?i aaiinoaco aoei a?aecia/aii, ui a ia??iae iaeneiaeueii ae?aaeaii? aeoeaiino? oa?iaio?a iaeo?io?e?a aecia/aeenue aeeaie? a?iieiaaoeyoe?ei? ii?ooaiiy ? caaeaaeue aenia?eiaioaeueieo oaa?ei (aei 30 %). Aecia/aiiy eiao?oe??ioa ei?aeyoe?? iieacaei cai?ioio caeaaei?noue i?ae aeoeai?noth eenei? oinoaoace ? eiiiiiaio?a cai?oath/i? nenoaie (aeey eiaeiiai iieacieea, yeee oa?aeoa?eco? noai cai?oath/i? nenoaie, eiao?oe??io ei?aeyoe?? (r) eieeaaany a?ae 0,86 aei 0,91, p<0,05). Ui ae noino?oueny ei?aeyoe?? i?ae ai?noii eenei? oinoaoace ? iieacieeaie, ye? oa?aeoa?ecothoue noai oea?eiie?oe/ii? nenoaie, oi eiao?oe??io ei?aeyoe?? aecia/eoe aoei iaiiaeeeai, oiio ui aoaiieiaee oano ? i?iae ia i?iaeoeoe aeaa?aaeaoe?? o?a?eio/o?a?eiiaaio ioe?iththoueny ye?nii, a ia e?euee?nii. Oei ia iaioa, i?e i?aeaeuaii? aeoeaiino? e?ciniiaeueieo oa?iaio?a o ieaci? ca?eueoo?oueny ai?no o?a?ei-iiiiia??a ? IAeO, ui na?ae/eoue i?i i?yio caeaaei?noue i?ae iieacieeaie. O ca’yceo c oeei, ii?oieia?/ia ae?aaiinoeea neiae?iio AeAC aoea i?iaaaeaia a ia??iae iaeneiaeueii? aeoeaiino? eenei? oinoaoace. Ii?oieia?/ia aeine?aeaeaiiy ia/?iee, eaaaiue, ie?ie, iaaeie?eiaeo caeic iieacaei iayai?noue i?e?io?iia?a: o?a?eiiaeo — o eaaaiyo, a?eo?ioeeoa?ieo — o eaaaiyo ? ie?eao; aa?aaaoe?? a?eo?ioeeo?a — a on?o aeine?aeaeoaaieo i?aaiao; ia?aioeiaoicii? aeeno?io?? c ae?eyieaie iae?ico ? iae?ia?ico — a iaaeie?eiaeo caeicao ? ia/?ioe?; ina?aaeeiaeo e?iaiaeeea?a — o ei?eia?e ?a/iaei? oa eainoe? iaaeie?eiaeo caeic ? ia?aioei? ia/?iee. Iiae?aia ea?oeia i?e?ioee?eoeyoi?iiai ?onea i?e AeAC-neiae?ii? iieno?oueny a i?aoeyo ?ioeo aaoi??a (I.O.Eaiueoeia, 1981; Ae.Ae.Ca?aeii, 1989; A.E.Eaeiueiaa, 1990; E.Redoeczi et al., 1969; U.Blayl et at., 1976), ui ua ?ac i?aeoaa?aeaeo? ?icaeoie AeAC-neiae?iio a aenia?eiaioaeueieo oaa?ei o iaoeo aeine?aeaeaiiyo i?e aaaaeaii? i?aia?aoo “Aoa-2”. Iaea?aeai? iaie i?iyae aenia?eiaioaeueiiai AeAC-neiae?iio ni?aiaaeathoue c ?ioeie eiai iiaeaeyie, aeeeeeaieie aaaaeaiiyi “Aeacieniio-3”, aiaeioieneiiaei oieii, ii?eaie, aaiieiaaoethth/eie io?ooaie ? o.i. (C.N.Aa?eaaai n niaao., 1988; A.I.Uaiioei n niaao., 1989; A.Ae.*a?noaie n niaao., 1990; A.E.Eaeiueiaa n niaao., 1990). Aeey i?aeoaa?aeaeaiiy ?nioaaiiy aeyaeaii? caeaaeiino? i?ae i?aeaeuaiiyi ooieoe?iiaeueii? aeoeaiino? e?ciniiaeueiiai aia?aoo iaeo?io?e?a ? ae?aaeaieie ii?ooaiiyie aaiinoaco a aeine?aeieo oaa?ei iiaeaethaaiiy aenia?eiaioaeueiiai AeAC-neiae?iio i?iaiaeeee a oiiaao i?eai?/aiiai a?aioeioeeoiiiaco i??einaiii. Iaea?aeai? aeai? a II a?oi? aeine?aeaeaiue na?ae/aoue i?i oa, ui i?ney aaaaeaiiy “Aoe-2” a oiiaao i?eai?/aiiy a?aioeioeeoiiiaco iaeo?io?eueiee eaeeioeeoic ia o?eueee ia ?icaeaaany, a e /enei iaeo?io?e?a o e?ia? ia 4 — 6 aeiao cieaeoaaeinue ia 18 —20 %. I?e oeueiio a e?noeiaiio iiceo e?ieee?a a?aecia/aeinue ciaioaiiy ee?oei a?aioeioeeoa?iiai ?yaeo c aaeueioaaiiyi i?ioean?a aec??aaiiy a 7 — 10 ?ac?a, a ?acoeueoao? /iai e a?aeaoaaeinue cieaeaiiy e?eueeino? iaeo?io?eueieo eaeeioeeo?a o ia?eoa?e/i?e e?ia?. I?ioeane ciaioaiiy /enea e?cinii ? a?aioe e?ciniiaeueieo eao?iiieo a?ee?a iaeo?io?e?a oa aaniethoiee ai?no aeaa?aioeueiaaieo ? aeaeao?ii?ciaaieo iaeo?io?eioeeo?a aoee 4 — 8 ?ac?a ieae/eie, i?ae o eiio?ieuei?e a?oi?. Oea, a naith /a?ao, iiynith?, ui aeoeai?noue ia?ea?iiai e?ciniiaeueiiai oa?iaioa — eenei? oinoaoace a ne?iaaooe? e?ia? aeine?aeieo oaa?ei aoea a 2,5 ?aca iaio ae?aaeaiith, i?ae o eiio?ieueieo e?ieee?a. Ciaioaiiy eiioeaio?aoe?? e?ciniiaeueieo oa?iaio?a o e?ia? oaa?ei noi?iaiaeaeoaaeinue cieaeaiiyi nooiaith ca?eueoaiiy IAE oa ?AE o an? no?iee aenia?eiaioo. Cia/aiiy IAE oa ?AE a ?? a?oi? aoee iaio ae?aaeaieie a na?aaeiueiio a 3 — 5 ?ac?a. Iaea?aeai? aeai? i?aeoaa?aeaeothoue oie oaeo, ui oa?iaioe iaeo?io?eueieo eaeeioeeo?a aeeiiothoue ?ieue aa?aaaoe?eiiai oaeoi?a (I.I.Aa?aaeiay, 1988; E.Ae?anea?, 1988; J.O’Flagerti, 1981; J.Wautier e.a.; 1983; D.Tsvetkov, 1987; I.Ginis, A.Tauber, 1990). Cieaeaiiy aeoeaiino? e?ciniiaeueieo oa?iaio?a iaeo?io?eueieo eaeeioeeo?a o e?ia? i?ecaiaeeei aei cia/iiai ciaioaiiy ii?ooaiue aaiinoaco. I?ney aaaaeaiiy “Aoe-2” a oiiaao i?eai?/aiiy a?aioeioeeoiiiaco a ia?o? aea? aeiae oei?i/oaaany /an ?aeaeueoeeo?eaoe?? ieacie (-29.3±1.38;?<0.001) ? o?iia?iiaee /an (-5.1±0.31;?<0.001), i?aeaeuoaaany ai?no o?a?eiiaaio (+21.8±5.38;?<0.001) ? c?inoaea aeoeai?noue OIII oaeoi?a (+ 12.8±3.76;?<0.01); a ieaci? e?ia? aecia/aeeny iiceoeai? i?iae aoaiieiaiai oanoo, a a ne?iaaooe? e?ia? — IAeO, ui na?ae/eoue i?i ?icaeoie a?ia?eiaaoeyoe?? (A.E.Eociee, 1981; A.I.Aeoayaa, 1985; E. Eaaaae, 1991). Iaeiae o ii??aiyii? c eiio?ieueiith a II a?oi? ci?ie iieaciee?a, ui oa?aeoa?ecothoue noaae?th a?ia?eiaaoeyoe??, aoee a na?aaeiueiio a 4 ?ace iaio ae?aaeai?. A ianooii? aeaa aei? /an ?aeaeueoeeo?eaoe?? ieacie (+1.5±8.65;?>0.5)
i?aeaeuoaaany aei aeo?aeieo aaee/ei, o?iia?iiaee /an (-2.1±0.37;?<0.001) aoa ua iacia/ii oei?i/aiee, iai?/aeany oaiaeaioe?y aei cieaeaiiy ai?noo o?a?eiiaaio (-9.6±3.32;?<0.02) ? aeoeaiino? OIII oaeoi?a (+2.5±4.09;?>0.5). Iiae?ai? ci?ie cai?oath/i? nenoaie a?aeiia?aeathoue
?icaeoeo noaae?? eiaaoeiiao?? niiaeeaaiiy (C.N.Aa?eaaai, 1988; E.Eaeye,
1991; A.E.A?eoethe, 1994).

Ia 5-o aeiao /an ?aeaeueoeeo?eaoe?? ieacie (+6.7±1.57;?<0.01) ? o?iia?iiaee /an (+1.3±0.54;?<0.02) aoee iacia/ii i?aeaeuai?, a aeoeai?noue XIII oaeoi?a (-4.9±1.30;?<0.001) cieaeaia, aea oe? ci?ie a?aeaoaaeenue o iaaeao ii?iaeueieo eieeaaiue iieaciee?a, ui aea/aeeny , a ai?no o?a?eiiaaio (-3.9±2.08;?>0.1) ia a?ae??ciyany a?ae
aeo?aeieo aaee/ei. I?iae ia aoaiieiaee oano ? i?iaeoeoe aeaa?aaeaoe??
o?a??io/o?a??iiaaio aoee iaaaoeaieie.

Noai cai?oath/i? nenoaie a oeae ia??iae ia a?aeia?aaeaa ??ceiai
niiaeeaaiiy oaeoi??a cai?oaiiy ? i?e ii?iaeueiiio ai?noo o?a?eiiaaio
na?ae/ea i?i oa, ui noaae?y a?iieiaaoeyoe?? a oiiaao i?eai?/aiiy
a?aioeioeeoiiiaco ia ?icaeaaeanue.

Ii/eiath/e c 6-? aeiae iieacieee cai?oath/i? nenoaie a?aeiiaethaaeenue.

Oaeei /eiii, ni?anoaaeyth/e ?acoeueoaoe iaoeo aeine?aeaeaiue c aeaieie
e?oa?aoo?e, iiaeia c?iaeoe aeniiaie, ui i?iyae ii?ooaiue aaiinoaco, ye?
ae?aaeathoueny eeoa a ?icaeoeo a?ia?eiaaoeyoe?eieo ci?i, ii noo?, ia
oa?aeoa?i? aeey AeAC-neiae?iio ye oaeiai a oe?eiio (I.N.Ia/aaaee, 1981;
N.A.Eaaeoeeay, 1984; A.A.Eu/aa, 1986; E.Eaaaae,1991; E. Eaeye, 1991; A.
E. A?eoethe, 1994).

Ii?oieia?/ia aeine?aeaeaiiy iieacaei, ui o aioo??oi?o i?aaiao
niinoa??aaeanue caaaeueia ea?oeia iiaiie??a’y i?e?ioee?eoeyoi?iiai ?onea
? iii??ii ae?aaeai? aeeno?io?/i? ci?ie ee?oei. Iiae?ai? ci?ie
i?e?ioee?eoeyoi?iiai ?onea i?aeoaa?aeaeo? iaoa aeiiouaiiy i?i oa, ui o
e?ieee?a a oiiaao i?eai?/aiiy a?aioeioeeoiiiaco i?ney aaaaeaiiy “Aoe-2”
AeAC-neiae?ii ia ?icaeaaany, a i?ioean iaiaaeoaaany eeoa
a?ia?eiaaoeyoe?eieie c?ooaiiyie, ui oa?aeoa?ii aeey no?an-neiae?iio
(I.O.Eaiueoeia, 1981; Ae.Ae.Ca?aeii, E.E.Eoeanaae/, 1983; I.E.Ia?iyeia,
1983; E.Regoeczi, 1969).

Aiae?coth/e ?acoeueoaoe iaoeo aeine?aeaeaiue, iiaeia oyaeoe oaeee
iaoai?ci ?icaeoeo AeAC-neiae?iio i?ney aaaaeaiiy “Aoe-2” ? ?ieue
iaeo?io?eueieo eaeeioeeo?a i?e oeueiio.

I?aia?ao “Aoa-2”, ui aeei?enoiaoaaany a oe?e ?iaio?, aeaioiaeaiee ia
iniia? io?ooe ci?? aoe aaaaoieoneaoi? (Echis multisgnomatus), aaaaeaiiy
yei?, ye ? ?ioeo ?a/iaei, caeaoieo aeeeeeaoe ?icaeoie AeAC-neiae?iio,
aeoeaothoue i?io?iia?i aai O oaeoi? (I.N.Ia/aaaee, 1970; A.E.Eociee,
1971, 1979; A.I.Aaeoaea, 1980; C.N.Aa?eaaai, 1985).

A iaoeo aenia?eiaioao i?ney aaaaeaiiy “Aoe-2” niinoa??aaeanue ??cea
aeoeaaoe?y oaeoi??a cai?oath/i? nenoaie, ui, i/aaeaeii, ? aoei
iaoiiaeaii i?yiith ae??th io?ooe ia i?io?iia?i aai O oaeoi? ieacie. Ia
iiaeia aeeeth/eoe ? i?yiee aieea e?ciniiaeueieo oa?iaio?a iaeo?io?eueieo
eaeeioeeo?a ia oaeoi? Oaaaiaia, ai naia a ia??iae ?icaeoeo
a?iieiaaoeyoe?eieo ii?ooaiue aaiinoaco, oa?aeoa?ieo aeey AeAC-neiae?iio,
aeoeai?noue eenei? oinoaoace aoea iaeneiaeueiith. Oei a?eueoa, ui ?
iiia?aaei?ie aeine?aeaeaiiyie iaoi? eaai?aoi??? anoaiiaeaia ia o?eueee
aeoeaaoe?y oaeoi?a Oaaaiaia ? caeaaeieo a?ae iueiai nenoai
e?ciniiaeueieie oa?iaioaie iaeo?io?eueieo eaeeioeeo?a, aea e
?icocaiaeaeaiiy cai?oath/i? ? o?a?eiie?oe/ii? nenoai i?e oi?ioaaii?
no?an-neiae?iio. E??i oiai, aeine?aeaeaiiyie Eocieea (A.E.Eociee,
A.I.Neeiao?ia, 1974; A.E.Eociee, ss.Ae.E?anee, 1979) aeiaaaeaii, ui
e?ciniiaeuei? oa?iaioe a?aioeioeeo?a, aieiae?th/e o?a?eiie?oe/iith
aeoeai?noth, iiaeooue nai? ii nia?, oiaoi aac o/ano? ieaci?io,
?icuaieyoe o?a?ei.

A ia??iae ae?aaeaiiai iaeo?io?eueico ? iaeneiaeueiiai aeoiaeo
e?ciniiaeueieo oa?iaio?a o e?ia aeeaiea a?iieiaaoeyoe?y, ui
?icaeaa?oueny, aae aei iiaiiai iacai?oaiiy e?ia?, ca aeaieie e?oa?aoo?e,
iiaea iiynithaaoenue, c iaeiiai aieo, ??ceei aeniaaeaiiyi oaeoi??a
cai?oath/i? nenoaie ? aenieei ??aiai ai?noo a ne?iaaooe? e?ia?
i?iaeoeo?a aeaa?aaeaoe?? o?a?eio/o?a?eiiaaio, a, c ?ioiai aieo,
aeoeaaoe??th Oaaaiai-caeaaeii? o?a?eiie?oe/ii? nenoaie e?ciniiaeueieie
oa?iaioaie iaeo?io?e?a ? aioeeiaaoeyoe?eieie oa o?a?eiie?oe/ieie
aeanoeainoyie inoaii?o.

Aeneiaeaia a?aoiaioaoe?y i?aeoaa?aeaeo?oueny aenia?eiaioaie c
i?eai?/aiiyi a?aioeioeeoiiiaco, iaeneiaeueiei iiaeaaeaiiyi aeoeaiino?
e?ciniiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a, ui i?ecaiaeeei aei
cieaeaiiy ai?noo eenei? oinoaoace ia 70%.

A oiiaao cieaeaii? eiioeaio?aoe?? e?ciniiaeueieo oa?iaio?a
iaeo?io?eueieo eaeeioeeo?a o ne?iaaooe? e?ia? noai cai?oath/i? ?
o?a?eiie?oe/ii? nenoai aecia/aany a?eueoith i??ith aieeaii ia oe?
i?ioeane eeoa “Aoe-2” ? ia oneeaaeithaaany e?ciniiaeueieie oa?iaioaie
iaeo?io?eueieo eaeeioeeo?a.

Oaea oaa?aeaeaiiyaeaea?oueny iaa?oioiaaiei, ine?eueee e?ciniiaeuei?
oa?iaioe iaeo?io?e?a ia eeoa aeoeaothoue oaeoi? Oaaaiaia, aea e iathoue
i?ioecai?oath/? o?a?eiie?oe/i? aeanoeaino?, ui i?e ?o aenie?e
eiioeaio?aoe?? i?ecaiaeeoue aei ?icaeoeo aeeaieeo a?iieiaaoeyoe?eieo
ii?ooaiue.

Oaeei /eiii, ?icaeoie AeAC-neiae?iio noi?iaiaeaeo?oueny ae?aaeaiei
iaeo?io?eueiei eaeeioeeoicii, iaoiiaeaiei aeoeaaoe??th
a?aioeioeeoiiiaco. I?aeaeuaiiy e?eueeino? oee?eoethth/eo iaeo?io?e?a
noi?iaiaeaeoaaeinue ciaioaiiyi ai?noo e?cinii o iaeo?io?eueieo
eaeeioeeoao ? i?aeaeuaiiyi aeoeaiino? ia?ea?iiai e?ciniiaeueiiai
oa?iaioa a ne?iaaooe? e?ia?. I?aeaeuoaaeenue aa?aaaoe?ei? aeanoeaino?
eaeeioeeo?a e?ia?.

Aea/aiiy iieaciee?a cai?oath/i? nenoaie i?e AeAC-neiae?ii? iieacaei, ui
?o ci?ie iia’ycai? c ??aiai aeoeaiino? eenei? oinoaoace a ne?iaaooe?
e?ia?.

I?eai?/aiiy a?aioeioeeoiiiaco o i?aeaeine?aeieo oaa?ei
noi?iaiaeaeoaaeinue cia/iei cieaeaiiyi aeoeaiino? eenei? oinoaoace, i?e
oeueiio a?aecia/aeinue ciaioaiiy ii?ooaiue aaiinoaco (i?ney aaaaeaiiy
“Aoe-2”) ? o?aaeaiue i?e?ioee?eoeyoe?? aioo??oi?o i?aai?a, ui caiia?aaei
?icaeoeo a?iieiaaoeyoe?eieo ci?i aaiinoaco, a, cia/eoue, ?
AeAC-neiae?iio.

Ioaea, iaie aeiaaaeaii iayai?noue ooieoe?iiaeueiiai ca’yceo i?ae noaiii
e?ciniiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a e?ia? ? ?icaeoeii
neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai cai?oaiiy e?ia?.

Aeniiaee

1.Ca?aeii c aeaieie e?oa?aoo?e, o/anoue e?ciniiaeueieo oa?iaio?a
iaeo?io?e?a o ?icaeoeo AeAC-neiae?iio ia aea/aeany. ?ai?oa aeine?aeaie,
i?iaaaeaieie a iao?e eaai?aoi???, aoei anoaiiaeaii, ui e?ciniiaeuei?
oa?iaioe iaeo?io?e?a ?aaoeththoue aaiinoac, ui aeaei i?aenoaao
aeiionoeoe, ui e?ciniiaeuei? oa?iaioe iaeo?io?e?a aa?ooue o/anoue o
?icaeoeo AeAC-neiae?iio.

2. I?e oi?ioaaii? AeAC-neiae?iio, aeeeeeaiiai aaaaeaiiyi i?aia?aoo
“Aoa-2”, a i?aai?ci? e?ieee?a ?icaeaaany iaeo?io?eueiee eaeeioeeoic,
aeoeaoaaany a?aioeioeeoiiiac, ciaiooaaany ai?no e?cinii ? a?aioe
e?ciniiaeueieo eao?iiieo a?ee?a o iaeo?io?eao oa c’yaeyeanue ae?aaeaia
aeoeai?noue ia?ea?iiai e?ciniiaeueiiai oa?iaioo eenei? oinoaoace a
ne?iaaooe? e?ia?.

3. I?e ?icaeoeo AeAC-neiae?iio ii?oooaaany aaiinoac, ui ae?aaeaeinue
??ceith aeoeaaoe??th oaeoi??a cai?oath/i? nenoaie c iinooiiaei ?o
aeniaaeaiiyi, ?icaeoeii aeeaiei? a?iieiaaoeyoe??, aae aei iiaiiai
iacai?oaiiy e?ia? a ia??iae iaea?eueoi? aeoeaiino? eenei? oinoaoace.

4. Ii?oieia?/ia aeine?aeaeaiiy aioo??oi?o i?aai?a o ia??iae
iaeneiaeueii? aeoeaiino? eenei? oinoaoace iieacaei iayai?noue
i?e?io?iia?a ? aa?aaao?a oi?iaieo aeaiaio?a e?ia? o i?e?ioee?eoeyoe??, a
oaeiae iae?ic?a ? aaii?aa?e.

5. A oiiaao i?eai?/aiiy a?aioeioeeoiiiaco i?ney aaaaeaiiy i?aia?aoo
“Aoa-2” iaeo?io?eueiee eaeeioeeoic ia ?icaeaaany, aecia/aeinue
aaeueioaaiiy a?aioeioeeoiiiaco, iacia/ii c?inoaea eiioeaio?aoe?y
e?ciniiaeueieo oa?iaio?a o ieaci? e?ia?.

6. A oeeo oiiaao ?icaeaaeenue eeoa a?ia?eiaaoeyoe?ei? ci?ie o
cai?oath/?e nenoai?, a a?iieiaaoeyoe?ei? ii?ooaiiy aaiinoaco aoee
a?aenooi?.

7. Ii?oieia?/ia aeine?aeaeaiiy aioo??oi?o i?aai?a na?ae/eoue i?i
iiaiie??a’y i?e?ioee?eoeyoe?? ? iii??ii ae?aaeai? aeeno?io?/i? ci?ie
ee?oei.

8. Aenieee ??aaiue aeoeaiino? e?ciniiaeueieo oa?iaio?a iaeo?io?e?a o
ieaci? e?ia? ? iaeiei c aecia/aeueieo oaeoi??a o ?icaeoeo
AeAC-neiae?iio.

Nienie iioae?eiaaieo i?aoeue

1. Iiaeaaaa A.A., Aiy?/oe A.Ae. Ninoiyiea nenoai, caaeneiuo io oaeoi?a
Oaaaiaia, a oneiaeyo aeaoeoeeoa einoeeia i?e aeaenoaee no?anni?a
eioaeoeeiiiie i?e?iaeu // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. — 1998.
— ?5. — N. 23 — 29.

2. Aiy?/oe A.Ae. Yenia?eiaioaeueiay iiaeaeue AeAN-neiae?iia // Aanoiee
i?iaeai aeieiaee e iaaeeoeeiu. — 1998. — ?7. — N. 132—138.

3. Aiy?/oe I.Ae., Iiaea?aa I.I. Noai e?ciniiaeueiiai aia?aoo
iaeo?io?eueieo eaeeioeeo?a i?e AeAC-neiae?ii? ? a oiiaao a?ii?inoe?iai??
i?e ae?? no?ani?a ia?ioaeoe?eii? i?e?iaee // Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu — 1998. — ?7. — N. 139—143.

4. Aiy?/oe A.Ae., Eoieia I.A. ?ieue iaeo?ioeeueiuo eaeeioeeoia a
?acaeoee AeAN-neiae?iia. // Aanoi. i?iae. aeieiaee e iaaeeoeeiu. — 1998.
— ?16. — N 39 — 44. .

5. Aiy?/oe I.Ae., Eoi?ia I.A. Aieea i?eai?/aiiy a?aioeioeeoiiiaco ia
ci?ie e?ciniiaeueiiai aia?aoo iaeo?io?eueieo eaeeioeeo?a i?e
AeAC-neiae?ii? // OV c’?cae Oe?. o?c?ieia?/i. oiaa?enoaa. — O?c?ie.
aeo?iae. — 1998. — O. 44, ?3. — N. 183.

6. Aiy?/oe I.Ae., Eoi?ia I.A. Aieea i?eai?/aiiy a?aioeioeeoiaco ia
oi?ioaaiiy AeAC-neiae?iio // Iaoa?. i?aeia?iaei. eiio. “A?iien?y:
aeano?oeoeaia oa eiino?oeoeaia ae?y”. — Ee?a. — 1998. — N. 39-40.

Aiioaoe??: Aiy?/oe I.Ae. ?ieue e?ciniiaeueiiai aia?aoo iaeo?io?eueieo
eaeeioeeo?a o oi?ioaaii? neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai
cai?oaiiy e?ia?. — ?oeiien.

Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe
ca niaoe?aeuei?noth 03.00.13 — o?c?ieia?y ethaeeie ? oaa?ei. — ?inoeooo
o?c?ieia?? ?i. I.I.Aiaiiieueoey IAI Oe?a?ie, Ee?a, 1998.

Aeena?oaoe?y i?enay/aia ?ie? e?ciniiaeueieo oa?iaio?a iaeo?io?eueieo
eaeeioeeo?a o ?icaeoeo neiae?iio aeenai?iiaaiiai aioo??oiueinoaeeiiiai
cai?oaiiy e?ia?. A ?iaio? aenoiooi i?eiouaiiy i?i oa, ui i?e oi?ioaaii?
AeAC-neiae?iio e?ciniiaeuei? oa?iaioe iaeo?io?e?a aa?ooue o/anoue o
ii?ooaii? aaiinoaco. Anoaiiaeaii, ui na?e aieea ia ii?ooaiiy aaiinoaco
aiie aeyaeythoue i?e iaaeoiaeaeaii? o e?ia a oiiaao ??cei ae?aaeaii?
eaeeioeeoa?ii? ?aaeoe?? ? aecia/athoue ?icaeoie aeeaieiai
a?iieiaaoeyoe?eiiai noaio. A aenia?eiaioao c i?eai?/aiiyi
a?aioeioeeoiiiaco iieacaia cai?ioia ei?aeyoeaia caeaaei?noue i?ae
aeoeai?noth e?ciniiaeueieo oa?iaio?a ? noaiii oaeoi??a cai?oath/i?
nenoaie e?ia? oa i?yia — c oaeoi?aie o?a?eiie?oe/ii? nenoaie.
Anoaiiaeai? ei?aeyoeai? ca’ycee iiaeooue aooe aeei?enoai? aeey iiyniaiiy
? ei?aeoe?? ii?ooaiue aaiinoaco i?e AeAC-neiae?ii?. ?aaoethaaiiy
eiioeaio?aoe?? e?ciniiaeueieo oa?iaio?a iaeo?io?e?a o e?ia? iiaea
caiia?aoe ?icaeoeo aeeaieeo a?iieiaaoeyoe?eieo c?ooaiue aaiinoaco a
oiae? ?icaeoeo neiae?iio AeAC.

Aiy?/oe A.Ae. ?ieue eeciniiaeueiiai aiia?aoa iaeo?ioeeueiuo eaeeioeeoia
a oi?ie?iaaiee neiae?iia aeennaieie?iaaiiiai aioo?eninoaeenoiai
naa?ouaaiey e?iae. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe
ii niaoeeaeueiinoe 03.00.13 — oeceieiaey /aeiaaea e aeeaioiuo. —
Einoeooo oeceieiaee ei. A.A.Aiaiiieueoea IAI Oe?aeiu, Eeaa, 1998.

Aeenna?oaoeey iinayuaia ?iee eeciniiaeueiuo oa?iaioia iaeo?ioeeueiuo
eaeeioeeoia a ?acaeoee neiae?iia aeennaieie?iaaiiiai aioo?eninoaeenoiai
naa?ouaaiey e?iae. A ?aaioa auaeaeiooi aeiiouaiea, /oi i?e oi?ie?iaaiee
AeAN-neiae?iia eeciniiaeueiua oa?iaiou iaeo?ioeeia i?eieiatho o/anoea a
ia?ooaiee aaiinoaca. Onoaiiaeaii, /oi naia aeeyiea ia ia?ooaiea
aaiinoaca iie i?iyaeytho i?e iinooieaiee a e?iaue a oneiaeyo ?acei
au?aaeaiiie eaeeioeeoa?iie ?aaeoeee e ii?aaeaeytho ?acaeoea aeoaieiai
aeiieiaaoeyoeeiiiiai ninoiyiey. A yenia?eiaioao n oaiaoaieai
a?aioeioeeoiiiyca iieacaia ia?aoiay ei??aeyoeaiay caaeneiinoue iaaeaeo
aeoeaiinoueth eeciniiaeueiuo oa?iaioia e ninoiyieai oaeoi?ia
naa?ouaathuae nenoaiu e?iae e i?yiay — n oaeoi?aie oea?eiieeoe/aneie
nenoaiu. Onoaiiaeaiiua ei??aeyoeeiiiua nayce iiaoo auoue eniieueciaaiu
aeey iauyniaiey e ei??aeoeee ia?ooaiee aaiinoaca i?e AeAN-neiae?iia.
?aaoee?iaaiea eiioeaio?aoeee eeciniiaeueiuo oa?iaioia iaeo?ioeeia a
e?iae iiaeao i?aaeioa?aoeoue ?acaeoea aeoaieeo aeiieiaaoeyoeeiiiuo
naeaeaia aaiinoaca a oiaea ?acaeoey neiae?iia AeAN.

Boyarchuk H.D. The role of lysosomal apparatus of neufrophy lic
leucocytes in formation of the disseminated intravascular blood
coagulation.

Thesis for candidate»s degree by speciality 03.00.13. — human and animal
physiologi. — O.O.Bogomoletz Institute of Physiology, Ukranian National
Acadamy of Science, Kyiv, 1998.

The dissertation is devoted to the role of neutrophylic leucocytes
(namely, its lysosomal apparatus) in formation of the disseminated
intravascular blood coagulation (DIC). It was supposed that under
condition of DIC the neutrophils lytic enzymes take part in hemostasis
state. It was established that these enzymes influenced on hemostasis
formation.

In experiments with granulocyte formation oppression it was been shown
that there was the inverse correlation between the lytic enzymes
concentration and the blood coagulation»s factors and the straight
correlation with the fibrinolytic system factors.

The established correlation could be used for explanation and correction
of the changes in hemostasis under DIC.

Regulation of the lytic enzymes concentrations in the blood
neutrophyles may prevent the development of deep hypocoagulation
hemostasis changes under DIC formation.

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