.

Роль карнозину у попередженні метаболічних порушень в печінці щурів при дії нітриту натрію: Автореф. дис… канд. біол. наук / О.М. Крисько, НАН Украї

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IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE

?INOEOOO A?IO?I?? ?i. I. A. IAEEAAe?IA

E?ENUeEI

IENAIA IEOAEE?AIA

OAeE 577.13+615.356+577.3:546.173

?IEUe EA?IICEIO O IIIA?AAeAEAII? IAOAAIE?*IEO

II?OOAIUe A IA*?IOe? UO??A I?E Ae?? I?O?EOO IAO??TH

03.00. 04 – A?io?i?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? a?io?i?? Euea?anueeiai aea?aeaaiiai
oi?aa?neoaoo ?i. ?aaia O?aiea.

Iaoeiaee ea??aiee – eaiaeeaeao a?ieia?/ieo iaoe, aeioeaio

Ei?iaia A’y/aneaa Ieeieaeiae/,

Euea?anueeee aea?aeaaiee oi?aa?neoao ?i. ?aaia O?aiea,

aeioeaio eaoaae?e a?io?i??.

Io?oe?ei? iiiiaioe – aeieoi? a?ieia?/ieo iaoe, i?ioani?

Noa?iaeoa Ieeiea Oaaei?iae/

?inoeooo a?io?i?? ?i.I.A.Iaeeaae?ia IAI Oe?a?ie

caa?aeoaa/ a?aeae?eo a?io?i?? naini?ieo oa ?aaoeyoi?ieo nenoai;

eaiaeeaeao a?ieia?/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee

A?otho Aaea??e Iao?iae/

Oe?a?inueeee iaoeiaee a?a??i?/iee oeaio? IIC Oe?a?ie,

i?ia?aeiee iaoe. ni?a?. eaai?aoi??? a?io?i?/ii? aaiaoeee.

I?ia?aeia onoaiiaa – *a?i?aaoeueeee aea?aeaaiee oi?aa?neoao ?i. TH??y
Oaaeueeiae/a,

eaoaae?a a?io?i??.

Caoeno a?aeaoaeaoueny « 25 » aeiaoiy 1999 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.240.01 a ?inoeooo? a?io?i??
?i. I.A.Iaeeaae?ia IAI Oe?a?ie (252601, Ee?a-30, aoe. Eaiioiae/a, 9).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo a?io?i??

?i. I.A.Iaeeaae?ia IAI Oe?a?ie (252601, Ee?a-30, aoe. Eaiioiae/a, 9)

Aaoi?aoa?ao ?ic?neaiee « 16 » aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao a?ieia?/ieo iaoe
E??NAIEI I.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie.

I?o?eoe iio?aieythoue aei i?aai?cio ethaeeie c aiaeith, ?aeath,
iia?o?yi, ye e?ea?nuee? i?aia?aoe ? aeeeeeathoue ?icaeoie
iaoaaiiaeia?iai?e, ye? a?aeiinyoue aei oeio oiene/ieo ?ioieneeaoe?e
aeciaaiiiai iioiaeaeaiiy (Aaeeia ss.E. e ae?., 1990; Na?aaeaiei I.I.,
1987; Eaaieoeeay I.O.; 1975). Ineieueee any aeeoo?aeiyeueiinoue eeioeie
iia’ycaia ?c cao?aoith aia?ai?, oi iaaeinoaoi? iaaeoiaeaeaiiy eenith
aiane?aeie iineeaiiai iaoaaiiaeia?iiooai?aiiy a ia?oo /a?ao
iicia/a?oueny ia ooieoeiiiaeueiiio noaii iioioiiae?ie. Aeanoaaieicaoeiy
eaeueoei?aiai aiiainoaco aianeiaeie iioeiaeaeaiiy nenoaie
iioioiiae?iaeueiiai o?ainii?oo aeaeo?iiia aeeeeea? aeniaaeaiiy
aioo?ioiueieeioeiiiai caiano AO? (Oinoaeianeay E.A., 1984). Oea
i?eaiaeeoue aei c?inoaiiy iaaaioaaeaiiy ia eeniaaiooeeicoth/o nenoaio.

C ae?oaiai aieo, eaioethaiaee i?ioean ieeneaiiy ieneaaiiaeia?io
i?eaiaeeoue aei iaa?iiaaeaeaiiy aeoeaieo eeniaaeo iaoaaie?o?a – I2-,
II., II2., I2I2 (Ooaaeae E.A. e ae?., 1998) oa a?eueieo ?aaeeeae?a,
ooai?aieo i?e a?aeiiaeaii? i?o?eo-?ii?a – NO oa NO2 (?aooia A.I., 1995).
Ci?ia noaoe?iia?ieo eiioeaio?aoe?e a?eueieo ?aaeeeae?a i?eaiaeeoue aei
?ioaineo?eaoe?? i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a (Ao?eaeiaa
A.A.e ae?., 1998; Aanoeaiaaaa ?.I. e ae?., 1998). A iipiaeueieo
o?c?ieia?/ieo oiiaao oaeaee?noue ipio?eaiiy a?eueiipaaeeeaeueieo
ipioean?a ?, a?aeiia?aeii, p?aaiue ipii?aeieo ? e?ioeaaeo ipiaeoeo?a
iapaeeniiai ieeneaiiy paaoeth?oueny neeaaeiith aaaaoieiiiiiaioiith
nenoaiith aioeieneaeaioiiai caoenoo ipaai?cio, yea aeeth/a? a naaa ye
oapiaioe-aioeieneaeaioe, oae ? iecueeiiieaeoeypi? ?ia?a?oipe
a?eueiipaaeeeaeueiiai ieeneaiiy (Yu B., 1994). A oiiaao a?iien??
iaaaioaaeaiiy ia aeaio nenoaio p?cei cpinoa?, a aeeaeia iioeiaeaeaiue,
aeeeeeaieo iaoieia?/ieie ipioeanaie, aoaea caeaaeaoe, a e?ioeaaiio
paooieo, a?ae ooieoe?iiaeueii? aeoeaiino? iepaieo eaiie aioeieneaeaioii?
nenoaie.

Iioeiaeaeaiiy, ni?e/eiai? a?eueieie ?aaeeeaeaie, iiaeooue aooe onoioo?
aeciaaiieie niieoeaie, ye? caoeuathoue i?aai?ci a?ae iane?aee?a
a?eueii?aaeeeaeueiiai ieeneaiiy. Ia?aaaaa iaaea?oueny i?e?iaeiei
aioeieneaeaioai, ine?eueee aeei?enoaiiy neioaoe/ieo i?aia?ao?a
e?i?oo?oueny iia?/ieie iaaaoeaieie aoaeoaie (Einoaiei E.O., 1990).
Aiaeiia ?ieue a?noeaeeiai?niiai aeeiaioeaeo ea?iiceio ye
iaia?aiii?ioaeoi?a i iecueeiiieaeoey?iiai iaoa?iaioaoeaiiai
aioeieneaeaioa (Aieaeu?aa A.A e ae?., 1992, 1993; Eeaaaiia A.E. e ae?.,
1998) niiioeaea aeineiaeeoe eiai aieea ia nenoaio ooee?caoe?? eenith oa
aioeieneaeaioio nenoaio ia/?iee ca oiia iio?eoii? iioieneeaoei?.

Aeeaiea aeineiaeaeaiiy i?ioieaiiy iio?eoii? iioieneeaoei? aeeeeeaia ia
eeoa iio?aaith o c’ynoaaiii aeaoaeueieo eaiie aieeao NO(–iiiia ia ?icii
iaoaaiei/ii nenoaie, aea e iia’ycaia c iaiaoiaeiinoth aea/aiiy i?ioeania
ia?aoai?aiiy iio?eo-iiiia o oeeee? ieceaeo acioo, ooieoeiiioaaiiy yeiai
iicia/a?oueny ia an?o nenoaiieo ??aiyo i?aai?cio. O oeeee? aa?ooue
o/anoue i?o?eo-?iie, aaiaiinii aieee, cie?aia, aaiiaeia?i oa ie?ai?
iecueeiiieaeoey?i? aioeieneaeaioe (?aooia A.I., 1995), i?ioa ia aeaiee
/an caeeoa?oueny iac’yniaaiei ieoaiiy o/ano? o oeueiio i?ioean?
aiaei?ic/eiiiai aioeieneaeaioa ea?iiceio. Oiio aoee i?iaaaeaii
aeineiaeaeaiiy c iaoith c’ynoaaiiy ?ie? aeeiaioeaeo o oeeeei ieneaeo
acioo.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeaia ?iaioa ? /anoeiith ooiaeaiaioaeueieo aeineiaeaeaiue eaoaae?e
a?io?i?? oa iaoeiai-aeineiaeii? eaai?aoi?i? iieaeoey?ii? oa
?aae?aoe?eii? a?io?i?? Eueaianueeiai aea?aeaaiiai oiiaa?neoaoo ii. Iaaia
O?aiea ca oaiaie: “Iecueeiiieaeoey?ii i?e?iaeii iaoaaieioe a ei?aeoei?
aiiiene/ieo noaiia i?aaiicio” (? aea?ae.?a?no?aoe?? 0197V018113) oa
“Aeine?aeaeaiiy iaoai?cio ae?? ea?iiceio ia iaoaaie?/i? ?aaeoe?? a
oiiaao a?iien?? ??cii? ao?ieia??” (? aea?ae. ?a?no?aoe?? 0195V026232).

Iaoa oa caaaeaiiy aeine?aeaeaiiy.

Iaoith aeaii? ?iaioe aoei aea/aiiy aieeao ainoeaeeiaiiniiai i?e?iaeiiai
aeeiaioeaeo ea?iiceio ia i?ioeane ia?aeeniiai ieeneaiiy eiiiaeia i
ooieoeiiioaaiiy nenoaie aioeieneaeaioiiai caoenoo (AIC) ia/iiee oa
aeineiaeaeaiiy ia?aiao?ia aeeoaiiy i ieeniiai oinoi?eethaaiiy
iioioiiae?ie ia/iiee ca oiia iio?eoii? iioieneeaoei?, a oaeiae aea/aiiy
?iei ea?iiceio o ooieoeiiioaaiii oeeeeo ieneaeo acioo.

Aeine?aeaeaiiy aieeao ea?iiceio ia i?ioeane ia?aoai?aiiy i?o?eo-?ii?a ca
o/anoth aaiiaeia?io.

Aeineiaeaeaiiy aiinoo i?iaeoeoia ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) oa
aeoeaiinoi oa?iaioia AIC o ia/iioei uo?ia ca oiia iio?eoii?
iioieneeaoei?, ?iaeoeiaaii? aaaaeaiiyi i?o?eoo iao??th.

Aea/aiiy aieeao ea?iiceio ia i?ioieaiiy i?ioeania IIE i ooieoeiiioaaiiy
AIC oa nenoaie ooeeicaoei? eenith a ia/iioei uo?ia ca oiia iio?eoii?
iioieneeaoei?.

Aeine?aeaeaiiy ?ie? ea?iiceio o ooieoe?iioaaii? eaoaeace i?e ae??
iio?eoo iao?ith.

Aeineiaeaeaiiy ia?aiao??a aeeoaiiy oa ieeniiai oinoi?eethaaiiy
iioioiiae?ie ia/iiee uo?ia i?e aaaaeaiii iio?eoo iao?ith.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a.

O i?aaenoaaeai?e ?iaio? aia?oa iieacaii, ui ea?iicei aieeaa? ia i?ioeane
ooai?aiiy i?o?iceeueiaaieo eiiieaen?a aaiiaeia?io, i?eaiaey/e aei ci?i
?ioaineaiino? AI? neaiae?a Hb(FeIII)- oa Hb(FeII)-eiiieaen?a.
Iaa?oioiaaia o/anoue aeeiaioeaeo o ooieoe?iioaaii? oeeeeo ieneaeo acioo.

Aia?oa i?iaeaiiino?iaaii ei?aaoth/ee aieea ea?iiceio ia ?ioaineai?noue
i?ioean?a IIE oa ooieoe?iioaaiiy oa?iaio?a aioeieneaeaioiiai caoenoo
i?aai?cio i?e ?icaeioo?e aaaaeaiiyi NaNO2 i?o?eoi?e ?ioieneeaoe??.
Aeyaeaia iaiaeiicia/i?noue aieeao ea?iiceio in vitro oa in vivo ia
aeoeai?noue eaoaeace i?e ae?? i?o?eoo iao??th.

Io?eiai? ?acoeueoaoe iieacaee, ui ea?iicei ?ioaineo?eo? i?ioean aeeoaiiy
o i?oioiiae??yo ia/?iee uo??a ca oiia i?o?eoii? ?ioieneeaoe?? i?e
aeei?enoaii? (-eaoiaeooa?aoo ye noano?aoo ieeneaiiy.

Oai?aoe/ia oa i?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a.

Io?eiai? aeai? ?icoe?ththoue oyaeaiiy i?i iaoai?ci aieeao i?o?eoo
iao??th ye aeciaaiiiai aeaea?aea ieneaeo acioo ia ooieoe?iioaaiiy
eeniaaiooee?coth/i? oa aioeieneaeaioii? nenoai ia/?iee uo??a ca oiia
i?o?eoii? ?ioieneeaoe??.

?acoeueoaoe aeine?aeaeaiiy aieeao ea?iiceio in vitro ia aeoeai?noue
eaoaeace a i?enooiino? i?o?eoo iao??th aeicaieythoue iaa?oiooaaoe
aioeieneaeaioio ?ieue ea?iiceio a oiiaao i?o?eoii? ?ioieneeaoe??.

Aeai?, ui noinothoueny ooai?aiiy eiiieaen?a aaiiaeia?io c ieneaeii
acioo, aeathoue ciiao iaa?oiooaaoe ?ieue ea?iiceio o ooieoe?iioaaii?
oeeeeo ieneaeo acioo a i?aai?ci? nnaaoe?a.

?acoeueoaoe aeine?aeaeaiue i?eaiaeyoue aei i?eioeeiiai iiaeo oyaeaiue
uiaei ?aaoeyoe?? iaoaaie?/ieo ii?ooaiue, ni?e/eiaieo NaNO2 ?
noai?ththoue oai?aoe/io iniiao aeey i?aeoe/ieo ?ic?iaie iiaeo
e?ea?nueeeo cania?a ia iniia? a?noeaeeiai?niiai i?e?iaeiiai aeeiaioeaeo
ea?iiceio aeey ei?aeoe?? iaoaaie?/ieo ii?ooaiue, ui aeieeathoue i?e
a?iiene/ieo noaiao i?aai?cio.

Iniaenoee aianie aeena?oaioa.

O i?ioean? aeeiiaiiy aeena?oaoe?eii? ?iaioe aaoi?ii naiino?eii
i?iaiae?ciaaii cia/iee ia’?i a?o/eciyii? oa caei?aeiiii? e?oa?aoo?e aeey
ieaioaaiiy oa ei?aeoiiai aeeiiaiiy iaoeiaeo aenia?eiaio?a. Aecia/aiiy
aeoeaiino? oa?iaio?a aioeieneaeaioiiai caoenoo ? ai?noo i?iaeoeo?a IIE a
ia/?ioe?, a oaeiae i?iaaaeaiiy iiaeaeueieo aenia?eiaio?a, iia’ycaieo c
aeine?aeaeaiiyi eaoae?oe/ieo oa niaeo?aeueieo oa?aeoa?enoee i?aia?aoo
eaoaeace a?eaa Penicillum vitale oa aeine?aeaeaiiy aieeao ea?iiceio ia
o?ceei-o?i?/i? aeanoeaino? aaiai?nieo a?ee?a i?iaaaeai? iniaenoi.
Aeine?aeaeaiiy ia?aiao??a aeeoaiiy oa ieeniiai oinoi?eethaaiiy
i?oioiiae??e ia/?iee i?iaaaeaii ni?eueii c? ni?a?ia?oieeaie IAeE-40
eaoaae?e o?c?ieia?? ethaeeie ? oaa?ei Euea?anueeiai aea?aeaaiiai
oi?aa?neoaoo ?iai? ?aaia O?aiea. ?a?no?aoe?y niaeo??a AI? i?iaaaeaia
eaiaeeaeaoii o?ce/ieo iaoe Iaaeeyeii A.A. ni?eueii ?c ni?a?ia?oieeaie
eaoaae?e a?io?ceee Iaaee/ii? Aeaaeai?? ?iai? Ethaea?ea ?eaeea???a i.
Aeaeaiu (Iieueua). Aiaeic oa iaaiai?aiiy ?acoeueoaoia aeineiaeaeaiue
i?iaaaeaii niieueii c iaoeiaei ea?iaieeii, aeioeaioii Ei?iaiaei A.I.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

?acoeueoaoe aeena?oaoei? aoee i?aaenoaaeaii ia 18-e Eiioa?aioe?? c
ieoaiue iaai?oiiai ?aciiaino (i. Iiciaiue, Iieueua, 1999); 2-e
Iiaeia?iaeiie Ia?ianianueeie eiioa?aioei? (i. Aaeainuee, Iieueua, 1998);
ia V Iiaeia?iaeiie eiioa?aioei? “Aeiaioeieneaeaio” (i. Iineaa, ?iniy),
ia 2-io Iiaeia?iaeiiio neiiicioii “Aeioeie/aneea iaoaieciu yiaeiaaiiie
eioieneeaoeee” (i. A?iaeii, A?ea?onue, 1997); ia VII-io Oe?a?inueeiio
aiioiii/iiio c’?caei (i. Ee?a, Oe?a?ia, 1997); ia V Anaoe?a?inueeie
nooaeaionueeie iaoeiaie eiioa?aioei? “Ioi?iia iaaeieeoiueiai na?aaeiaeua
i ?aoeiiiaeueia aeei?enoaiiy i?e?iaeieo ?ano?nia (Aeiiaoeuee, Oe?a?ia,
1995); ia aeiiiaiaei-naiiia?i “Ia?ae/iua oioioece/aneea e oioioeie/aneea
i?ioeannu a aeinenoaiao ?acee/iuo o?iaiae i?aaiecaoeee” (Ai?iiaae,
?iniy, 1996); ia Iiaeia?iaeiiio neiiicioii “Eenei?iae e naiaiaeiua
?aaeeeaeu” (A?iaeii, A?ea?onue, 1996); ia Iiaeia?iaeiiio neiiicioii
“Aieiieeneiou e eo i?iecaiaeiua” (A?iaeii, A?ea?onue, 1996).

No?oeoo?a oa ianya aeena?oaoe??

Aeena?oaoe?y neeaaea?oueny c anooio, o?ueio ?icae?e?a (iaeyae
e?oa?aoo?e, iaoa??aee ? iaoiaee aeine?aeaeaiue, ?acoeueoaoe oa ?o
iaaiai?aiiy), aeniiae?a oa nieneo aeei?enoaieo aeaea?ae, yeee i?noeoue
233 iaeiaioaaiiy. Ianya ?iaioe noaiiaeoue 129 noi??iie. Aeena?oaoe?y
i?i?ethno?iaaia 15 oaaeeoeyie oa 13 ?enoieaie.

INIIAIEE CI?NO ?IAIOE

Iaeyae e?oa?aoo?e. ?icaeyiooi iniiai? i?e/eie aeieeiaiiy ? ?icaeoeo
aai?/ii? a?iien??, ?iaeoeiaaii? i?o?eoii iao??th oa iienaii iaoai?cie
ae?? i?o?eoo iao??th ia aaiiaeia?i. Aena?oeaii ieoaiiy i?io?eaiiy
a?eueii?aaeeeaeueieo i?ioean?a oa noaio aioeieneaeaioii? nenoaie ca oiia
a?iiene/iiai no?ano, a oaeiae aieeao aeoeaieo oi?i eenith ia
ooieoe?iioaaiiy aeeoaeueiiai eaioethaa i?oioiiae??e. Iienai? aoaeiaa,
iioe?aiiy, iiaeeea? iaoai?cie ae?? i?e?iaeiiai a?noeaeeiai?niiai
aeeiaioeaeo ea?iiceio, caa?iooi oaaao ia ni?yaeai?noue eieae?caoe?? oa
ooieoe?e ea?iiceio.

Iaoa??aee ? iaoiaee aeine?aeaeaiue. Ia’?eoii aeine?aeaeaiue aoea ia/?iea
oa e?ia uo??a, ianith 180-220 a, o yeeo aeeeeeaee i?o?eoio
?ioieneeaoe?th. ?? iiaeaethaaee i?aeoe??iei aaaaeaiiyi i?o?eoo iao??th o
aeic? 50 ia/ea iane oaa?eie (Eaaieoeeay I.O., 1975). ?icaeoie i?o?eoii?
?ioieneeaoe?? eiio?iethaaee ca c?inoaiiy ai?noo iaoaaiiaeia?io o e?ia?
aeine?aeaeoaaieo oaa?ei, yeee aecia/aee ca aeiiiiiaith i’yoeoaeeueiaiai
iaoiaeo aecia/aiiy ni?aa?aeiioaiiy e?aaiaeieo oi?i aaiiaeia?io
(Nooiieeiia A.O., 1988). Aoaeo ae?? ea?iiceio ia i?io?eaiiy i?o?eoii?
?ioieneeaoe?? aeine?aeaeoaaee i?e eiai ia?i?aeueiiio aaaaeaii? o aeic?
70 ia/ea iane iaeii?aciai oa uiaeaiii i?ioyaii 9 aei?a ia?aae i?o?eoiith
?ioieneeaoe??th. Ia’?eoaie iiaeaeueieo aeniapeiaio?a neoaeea ?ic/ei
e?enoaei/iiai i?aia?aoo eaoaeace, aeaeieaii? c a?eaa Penicillum vitale
(Eaiainueeee aeine?aeiee a?io?i?/iee caaiae).

Aeine?aeaeaiiy niaeo?aeueieo oa?aeoa?enoee aaiiaeia?io oa eaoaeace
i?iaiaeeee iaoiaeii aaeni?aoe?eii? niaeo?ineii?? c aeei?enoaiiyi
niaeo?ioioiiao?a «Specord M-40» (I?ia//eia) oa AI?-niaeo?ineii?? c
aeei?enoaiiyi ?aaeiiniaeo?iiao?a oeio RADIOPAN SE/X-2544 (Iieueua).

O iiaeaeueieo aenia?eiaioao ii ?ieoaaoe?? eaoaeace c ea?iiceiii a
i?enooiino? NaNO2 e?enoaei/iee oa?iaio ?ic/eiyee a 0.02 I K-Na
oinoaoiiio aooa?i (?I 7.0); iioe/ia aonoeia ?ic/eio noaiiaeea 0.600 i?e
406 ii. A i?iao aiineee ea?iicei i NaNO2 a ?iciie iineiaeiaiinoi oa
iieoaoaaee 10 oa i?e oaiia?aoo?i 37iN (?o eiioeaio?aoeiy a ?aaeoeieiiio
na?aaeiaeui noaiiaeea 1.2 ia/ie i 0.37 ia/ie aiaeiiaiaeii). Noiio
ea?iiceio i NaNO2 io?eioaaee i?e 10-oaeeeiiie iieoaaoei? oeeo niieoe a
aeaiiiey?ieo eieueeinoyo.

Aeoeaiinoue noia?ieneaeaeeniooace (NIAe) aecia/aee ca aeiiiiiaith
?aaeoei? aiaeiiaeaiiy iio?ioao?acieith neiueiai aei iio?ioi?iacaio
(*aaa?e N., 1991), eaoaeace – c aeei?enoaiiyi ?aaeoei? I2I2 c
iieiaaeaoii aiiiith (Ei?iethe I.A., 1988). Aiino aei?iiaeo eii’thaaoia
aecia/aee ca iioaineaiinoth iiaeeiaiiy eii’thaiaaieo aei?iiaeo no?oeoo?
aiae?iia?ieneaeia eiiiaeia a iaeanoi 232-234 ii (Aaa?eeia I.E., 1983),
?iaaiue OAE-iiceoeaieo i?iaeoeoia ca iioaineaiinoth caaa?aeaiiy
eiiieaeno IAeA c oiiaa?aioo?iaith eeneioith (Oeio?aoeaoia ?.A., 1981).
Aeoeai?noue eaoaeace a aenia?eiaioao in vitro i?iaiaeeee,
aeei?enoiaoth/e niaeoioioiiao?e/iee i?yiee iaoiae ?iceeaaeo ia?ieneaeo
aiaeith eaoaeacith (Bergmeyer H.U., 1974). O?eueo?aoe eaoaeace,
?ieoaiaaii? c ea?iiceiii oa i?o?eoii iao??th, io?eioaaee
oeaio?eooaoaaiiyi i?e 7000g i?ioyaii 30 oa i?e oaiia?aoo?? 4(N. O
oieueo?aoi aecia/aee eiioeaio?aoeith ainoeaeeiaiinieo niieoe iaoiaeii
Iaoei (Eo/a?aiei I.A., 1988). Oaeaee?noue aeeoaiiy oa ieeniiai
oinoi?eethaaiiy o i?oioiiae??yo ia/?iee uo??a aecia/aee ca aeiiiiiaith
o?iiiaiia?iiao?e/iiai iaoiaeo (O?aie A.I., 1975; Eiaaeaiei A.A., 1975).

?acoeueoaoe oa ?o iaaiai?aiiy.

Aieea ea?iiceio ia oiceei-oiii/ii aeanoeainoi aaiiaeiaiio ca oiia
iio?eoii? iioieneeaoei?. Ia?oith eaieith, yea cacia? iioeiaeaeaiue i?e
ae?? i?o?eo-?ii?a ? aaiiaeia?i. Ae?y iaoaaiiaeia?iiooai?thaa/a
i?iyaey?oueny ia?o ca ana a ieeneaii? ieneaaiiaeiaiio aei
iaoaaiiaeiaiio, ui, a ia?oo /a?ao, aiaeia?aaea?oueny o ciiiao
eiioi?iaoeieiiai noaio oeueiai aaiii?ioa?io. C i?aaenoaaeaieo ia ?enoieo
1.1a aeaeo?iiieo niaeo?ia aeaeii, ui iaeii?aciaa iiia?aaei? aaeeaaiiy
ea?iiceio i?e ianooiiiio aaaaeaii? i?o?eoo iao??th i?eaiaeeoue aei
cieaeaiiy ?ioaineaiino? iiaeeiaiiy na?oea i?e 505 ii oa 630 ii ii??aiyii
c a?aeiia?aeieie ae?eyieaie aeaeo?iiieo niaeo??a aaiie?cao?a
a?eo?ioeeo?a oaa?ei, yeei ia?aae i?o?eoiith ?ioieneeaoe??th ia aaiaeeee
ea?iicei. Ca?eueoaiiy oa?i?io aaaaeaiiy aeeiaioeaeo aei 9 aei?a aeeeeea?
c?inoaiiy ?ioaineaiino? iiaeeiaiiy na?oea o i?iaiae?ciaaieo aeua
ae?eyieao aeaeo?iiiiai niaeo?o (?en. 1.1a). Aeyaeaiee aoaeo naiae/eoue
i?i oa, ui ea?iicei i?e iio?eoiie iioieneeaoei? iiaeoeo? cia/ii ciiie a
aeaeo?iiiiio niaeo?? aaiiaeia?io.

Aeinooii?noue aaiiai? eeoai? ciai?oi?i ieenieeai (o iaoeo
aeine?aeaeaiiyo NO2–?iiai), a iniiaiiio, iia’ycaia ?c i?ioiioaaiiyi
aeenoaeueiiai a?noeaeeio aaio aaiiaeia?io. sse na?ae/aoue ?acoeueoaoe
iaoeo aenia?eiaio?a, ea?iicei iiaea aaciina?aaeiuei aieeaaoe ia i?ioean
i?ioiioaaiiy aeenoaeueiiai a?noeaeeio aaiiaeia?io. Aeeiaioeae iiaea
ca’ycoaaoe i?ioiie (Neoea/ia A.I., 1992), eiioeaio?aoe?y yeeo c?inoa?
aiane?aeie ?icaeoeo aoeeaeico i?e aaaaeaii? i?o?eoo iao??th (Na?aaeaiei
I.I., 1990). I/aaeaeii, aiane?aeie ca’ycoaaiiy H+-?ii?a ea?iiceiii
niia?eueithaaoeiaoueny i?ioean i?ioiioaaiiy aeenoaeueiiai a?noeaeeio oa
cieaeoaaoeiaoueny ai?no iaoaaiiaeia?io o e?ia? aeine?aeaeoaaieo oaa?ei,
ye? io?eioaaee ea?iicei ia?aae i?o?eoiith ?ioieneeaoe??th a ii??aiyii? c
oaa?eiaie, yeei

?en. 1.1. Aeaeo?iii? niaeo?e aaiiaeia?io aaiie?cao?a a?eo?ioeeo?a
?ioaeoieo uo??a (1); uo??a, ye? io?eioaaee ea?iicei (2); yeei ca 50 oa
aei aeaeai?oaoe?? aaiaeeee NaNO2 (3); yeei aaiaeeee NaNO2 i?ney
iiia?aaeiueiai aaaaeaiiy ea?iiceio (4).

a – iaeii?aciaa aaaaeaiiy ea?iiceio; a – 9-?aciaa aaaaeaiiy ea?iiceio.

aaiaeeee i?o?eo iao??th aac iiia?aaeiueiai aaeeaaiiy aeeiaioeaeo. Iaeiae
ne?ae caoaaaeeoe, ui cieaeaiiy i?ioeano iaoaaiiaeia?iiooai?aiiy
niinoa??aaeinue i?e iaeii?aciaiio aaeeaaii? ea?iiceio, oiae? ye 9-aeaiia
aaaaeaiiy aeeiaioeaeo i?eaiaeeei aei ?ioaineo?eaoe?? i?ioeano ieeneaiiy
ieneaaiiaeia?io i?e ae?? i?o?eoo iao??th. I/aaeaeii, iaiaeiicia/i?noue
io?eiaieo ?acoeueoao?a iiaeia iiynieoe ia o?eueee ??ciei oa?i?iii
aaaaeaiiy aeeiaioeaeo, aea e neeaaeiei aei e?ioey ia c’yniaaiei
iaoaaie?ciii ea?iiceio a i?aai?ci?. Aeyaeaiee aoaeo iiaeneeaiiy
iaoaaiiaeiaiiiooai?aiiy i?e 9-aeaiiiio aaaaeaiii ea?iiceio iiaea
?aaeicoaaoenue oeyoii aaciina?aaeiuei? aca?iiaei? iaeiiai c i?iaeoeoia
?icuaieaiiy ea?iiceio – L-a?noeaeeio c aaiiaith eiiiiiaioith Hb
(Ei/aoeia I.E., 1985). Ainoeaeei, ui ooai?th?oueny i?e ?icuaieaii?
ea?iiceio, eaaei i?iieea? /a?ac iaia?aio a?eo?ioeeoa, a?i iiaea
eiieo?oaaoe ca ia?a?iciiaeie aeaeo?iiia c aeenoaeueiei ainoeaeeiii
aaiii?ioa?io a aeinooiiie aeey ?ic/eiieea iaeanoi aaio, a oea, a naith
/a?ao, i?eaiaeeoeia aei aeaoi?iaoei? aeoiaeii? eii?aeeiaoeieii? noa?e
aaiiaiai caeica ? aoaea i?iyaeyoenue ye iineeaia
iaoaaiiaeiaiiiooai?aiiy.

Io?eiai? ?acoeueoaoe ei?aeththoue ?c aeaieie AI?-niaeo?ineii??.

sse aeaeii c i?aaenoaaeaieo ia ?en. 1.2 niaeo??a AI? o e?ia? ?ioaeoieo
uo??a oa uo??a, yeei aaiaeeee eeoa ?ic/ei ea?iiceio, AI? neaiae aoa
a?aenooi?e.

?en. 1.2. AI? niaeo?e e?ia? uo??a, ca?a?no?iaai? i?e T=77K: ?ioaeoieo
oaa?ei(a); i?ney ia?i?aeueiiai aaaaeaiiy ea?iiceio (aeica – 70 ia/ea
iane oaa?eie) (a); i?ney aaaaeaiiy NaNO2 (aeica – 50 ia/ea iane oaa?eie)
(a).

I?ney aaaaeaiiy NaNO2 o AI? niaeo?? e?ia? c’yaey?oueny 2 oeie neaiae?a
AI?. O iecueeiiieueia?e iaeano? niaeo?o niinoa??aa?oueny neaiae ?c
g=6.00(0.01, oa?aeoa?iee aeey FeIII (6S5/2, 3d5) iaoaaiiaeia?io (?en.
1.3a). Oe?ieee neaiae c g=2.030+0.001 o aenieiiieueia?e /anoei? o?eieao
a?aeiia?aea? eiiieaenai aaiiaeia?io c ieceaeii acioo (?en. 1.3a).

I?e 9-aeaiiiio aaaaeaii? ea?iiceio ?ioaineai?noue neaiaeo, ui
noino?oueny Hb(FeIII), iacia/ii c?inoaea a ii??aiyii? c aaee/eiith, yea
?a?nooaaeanue o AI? niaeo?ao e?ia? uo??a, yeei aaiaeeee i?o?eo iao??th
aac iiia?aaeiueiai aaeeaaiiy ea?iiceio (?en. 1.3a). Niinoa?aaeoaaiee o
aenieiiieueia?e iaeano? AI?-neaiae oa?aeoa?eco?oueny c?inoaiiyi
iioaineaiinoi neaiaeo i?o?iceeueiaaieo eiiieaen?a ii??aiyii ?c
aaee/eiith neaiaeo o e?ia? oaa?ei, yeei aaiaeeee NaNO2 aac
iiia?aaeiueiai aaaaeaiiy aeeiaioeaeo. Oaeee oei neaiaeo aiaeiiaiaea?
Hb-NO eiiieaenai o R- oa O-noaii (?en. 1.3a).

O i?aaenoaaeaiiio ia ?en. 1.3a AI? niaeo?? ?ioaineai?noue neaiaeo, ui
a?aeiia?aea? aenieini?iiaiio cae?co iaoaaiiaeia?io i?e iaeii?aciaiio
aaaaeaii? ea?iiceio ia?aae i?o?eoiith ?ioieneeaoe??th cieaeo?oueny
ii??aiyii c aaee/eiith ?ioaineaiino? neaiaeo, yea niinoa??aa?oueny i?e
aaaaeaii? NaNO2 aac ea?iiceio (?en. 1.3a). Ca oaeeo oiia
niinoa??aa?oueny ciaioaiiy ?ioaineaiino? neaiaeo Hb-NO eiiieaen?a (?en.
1.3a). Oaeee oei neaiaeo aiaeiiaiaea? eiiieaenai aaiiaeia?io c ieneaeii
acioo o O-noaii.

?en. 1.3. AI? niaeo?e e?ia? uo??a, ca?a?no?iaai? i?e T=77K: i?ney
aaaaeaiiy NaNO2 (a); i?ney iiia?aaeiueiai 9-?aciaiai aaaaeaiiy ea?iiceio
ia oii? i?o?eoii? ?ioieneeaoe?? (a); i?ney iiia?aaeiueiai 1-?aciaiai
aaaaeaiiy ea?iiceio ia oii? i?o?eoii? ?ioieneeaoe?? (a).

Ci?ie ?ioaineaiino? neaiaeo AI?, yeee a?aeiia?aea? aenieini?iiaiio
cae?co iaoaaiiaeia?io, i/aaeaeii, iia’ycai? ?c aieeaii ea?iiceiiaiai
a?noeaeeio, yeee i?noeoue o?aoeiiee acio i iiaea aeiyoe ye (- i
(-aeiii?, ia ieenii-a?aeiiaiee noai aaiiaiai cae?ca. Nooo?aa ciaioaiiy
?ioaineaiino? neaiaeo o iecueeiiieueia?e iaeano? i?e iaeii?aciaiio
aaaaeaii? ea?iiceio ie iia’yco?ii ?c aieeaii ea?iiceio ia a?aeiiaeaiiy
Fe3+ aei Fe2+. Caoaaaeeii, iaeiae, ui 9-?aciaa aaaaeaiiy ea?iiceio
i?aeoe/ii ia ci?ith? ?ioaineai?noue neaiaeo aenieini?iiaiai cae?ca
ii??aiyii c aaee/eiith aeey e?ia? uo??a c i?o?eoiith ?ioieneeaoe??th,
yeei ia aaiaeeee ea?iicei. I/aaeaeii, oaeee oa?i?i aaaaeaiiy ea?iiceio
ia aeinoaoi?e aeey i?ioeano a?aeiiaeaiiy Fe3+ iaoaaiiaeia?io.

O ia?ao?ae i?o?iceeueiaaieo eiiieaen?a aaiiaeia?io (Henry A., 1996),
?aaoethth/e oaeei /eiii eiioeaio?aoe?th ieneaeo acioo a i?aai?ci?.
Aeine?aeaeoaai? aoaeoe ea?iiceio iathoue aaaeeeaa cia/aiiy aeey
c’ynoaaiiy ?ie? aeeiaioeaeo o ooieoe?iioaaii? oeeeeo NO.

Ia?aeenii i?ioeane o oeaieii ia/iiee uo?ia ca oiia iio?eoii?
iioieneeaoei? i?e iiia?aaeiueiio ia?i?aeueiiio aaaaeaiii ea?iiceio.
NO2–iiie, ieenethth/e aoii caeica iieaeoee aaiiaeiaiio, iicaaaeythoue
?? caeaoiinoi cai?ioiuei ca’ycoaaoe eenaiue, ui, a naith /a?ao,
i?eaiaeeoue aei cieaeaiiy ?I2 i ?icaeoeo aiiieni? a oeaieiao. I?e oaeiio
aieeai aeei?enoaiiy eenith a eeioeii cnoaa?oueny a aie aeoeaaoei?
i?ioeania IIE. I?i oea naiae/aoue iaaaaeai? o oaae. 2.1 aeaii
caieueoaiiy aiinoo OAE-iiceoeaieo i?iaeoeoia oa i?ii?aeieo

Oaae. 2.1 Aeoeaiino? oa?iaioia AIN oa aiino i?iaeoeoia IIE o ia/iioei
uo?ia i?e 1- oa 9- ?aciaiio aaaaeaiii ea?iiceio ca oiia iio?eoii?
iioieneeaoei? (n=8-12)

Iieacieee

A?oie ?ioaeoi? NaNO2 Ea?iicei + NaNO2 (1-?aciaa) Ea?iicei +
NaNO2 (9-?aciaa)

Eaoaeaca,iiieue I2I2 ca oa a ia a?eeo

586.42(7.36

433.95(24.70

532.89(12.42**

615.74(17.28

NIAe, II/ia a?eeo 132.24(4.20 78.82(2.84* 104.83(5.67** 101.30(3.71

OAE-iiceoeai? i?iaeoeoe

iiieue/ia a?eeo 0.99(0.023 1.85(0.05* 0.98(0.05** 0.85(0.08**

AeE, iiieue/ia a?eeo 2.14(0.09 4.13(0.12* 2.23(0.09** 2.15(0.05**

* – ??cieoey a??ia?aeia ii??aiyii ?c eiio?ieai (?ioaeoi? oaa?eie),
p

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