1

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

AeIOOIANUeEA OAOssIA IEEIEA?AIA

OAeE: 616.233.-002-036.12:577.156.1:/

612.112.017.1:612.118.221.8/08

?IEUe AIAeIAAIIEO, AAIAOE*II COIIAEAIEO,

OAEOI??A O ?ICAEOEO O?II?*IIAI A?IIO?OO

O ?IA?OIEE?A IEEIAEO I?IOAN?E IAOEIIAOAeOAAIIss

14.01.02 — Aioo??oi? oai?iae

A A O I ? A O A ? A O

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioo aeeiiaii a Oa?e?anueeiio ?inoeooo? oaeineiiaeaiiy e?ea??a IIC
Oe?a?ie.

Iaoeiaee ea??aiee — aeieoi? iaaee/ieo iaoe Oea/ Na?oeaia

?aai?aia, Oa?e?anueeee ?inoeooo
oaeineiiaeaiiy

e?ea??a, i?ioani? eaoaae?e a?a??ie oa
i?ioan?e-

ieo caoai?thaaiue

Io?oe?ei? iiiiaioe — aeieoi? iaaee/ieo iaoe, i?ioani?

Einothe ?iia Oaaei??aia, Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/

eaoaae?ith aioo??oi?o ? i?ioan?eieo oai?ia

— aeieoi? iaaee/ieo iaoe, i?ioani?

E?anithe Ieaia Iao?ee??aia, Ee?anueeee
?inoeooo

iaaeeoeeie i?aoe? AII Oe?a?ie, caa.
a?aeae?eii

i?ioan?eii? iaoieia??

I?ia?aeia onoaiiaa – Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaea-

i?y IIC Oe?a?ie, eaoaae?a
oieoaeueii?

oa?ai?? ?1 ? i?ioiaoieia??

Caoeno a?aeaoaeaoueny “ 25 ” aa?aciy 1999 ?. i 13.30 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 o Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca aae?anith:

310022, i. Oa?e?a, i?iniaeo Eai?ia, 4.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, i. Oa?e?a, i?.Eai?ia, 4.

Aaoi?aoa?ao ?ic?neaiee 23 ethoiai 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe
E.?.Ia/a?aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie O no?oeoo?? o?ii?/ieo ianiaoeeo?/ieo caoai?thaaiue
eaaai?a (OICE) iaeia c ia?oeo i?noeue caeia? o?ii?/iee a?iio?o (OA), ia
aeieth yeiai i?eoiaeeoueny a?ae 65 aei 90% aeiaaee?a. O ca’yceo c
aaeeeei ?iciianthaeaeaiiyi, iaaieiiei c?inoaiiyi e?eueeino?
caoai?thaaiiy, ?aiiueith ?iaae?aei?noth oa aenieith nia?oi?noth OA,
ii?yae c ?oai?/iith oai?iaith na?oey, ii i?aao aaaaea?oueny “oai?iaith
a?eo” .

Iaei??th c oi?i OA c a?aeiiith ao?ieia??th ? o?ii?/iee a?iio?o, ui
aeieea? i?ae ae??th eiiieaeno oe?aeeeaeo i?iieneiaeo oaeoi??a, oe?iei
?iciianthaeaeaiee na?aae oaooa??a, ?ia?oiee?a cae?ci?oaeieo oaoo, a
oaeiae na?aae i?aoe?aiee?a ie?aieo i?ioan?e iaoeiiaoaeoaaiiy (Iyaeia
E.E., Iaca? I.N., 1991; Ieeeoaieiaa A.A., Eaaiiaa E.N., 1996).

Cia/io ?ieue o ?icaeoeo OA iathoue ??ci? aiaeiaaii? oa aeciaaii?
oaeoi?e, na?aae yeeo i?ia?aeia i?noea iaeaaeeoue ieeiaiio oaeoi?o:
o?eaaeino? ieeiaiai noaaeo, eiioeaio?aoe?? ieeo, a?aenioeo ai?noo
a?eueiiai aeaiieeno e?aii?th, ??ciiiai?oiei eiiiiiaioai iiae?aceeai? e
aea?a?coth/i? ae?? (Eeaeia? A.E. e ae?., 1990; Ieeeoaieiaa A.A., 1990).

Ca inoaii? ?iee c’yaeeeny aeine?aeaeaiiy, ye? i?aeoaa?aeaeothoue aaeeea
cia/aiiy o ?icaeoeo a?iioi-eaaaiaai? iaoieia?? niaaeeiai-aaiaoe/ii?
noeeueiino?, aeyaeaiiy yei? iiaea aooe aeei?enoaii i?e i?iaaaeaii?
i?ioa?aeai?o oa iaaeeei-aaiaoe/iiai eiinoeueooaaiiy. C?iaeaii ia?o?
ni?iae aeyaeoe noeeuei?noue aei oai?ia eaaai?a oa a?iio?a ca oaeeie
aaiaoe/ieie ia?ea?aie, ye aioeaaie nenoaie HLA (Darke C. et al., 1993;
Oaeoiaa I.I. e ae?., 1991), 1-?ia?a?oi?e i?ioa?iac (1-?I) (Eocuei?ia
E.I., 1997; Brown R.J. et al., 1996), aea?iaoiae?o?/i? iieacieee
(Eeaeia? A.E., Iaeio/aiei A.I., Cineiia A.I. e ae?., 1988).

Aeine?aeaeaiiy anioe?aoe?e aai?a nenoaie HLA c OICE i?iaaaeai? iiee ui
ia iaaaeeeeo aea??eao. Aeoaea iaei ioae?eaoe?e i?i aieea HLA-aioeaai?a
ia ?icaeoie OA a?ae ae?? ieeiaiai oaeoi?o. O ca’yceo c oeei, a?aoiaoth/e
aoi?/i? e iiioeyoe?ei? iniaeeaino? ?iciianthaeaeaiiy aioeaai?a HLA,
aeioe?eueiei ? c’ynoaaiiy ?o ?ie? o ?icaeoeo ? ia?aa?ao o?ii?/iiai
a?iio?oo o ?ia?oiee?a ??cieo ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy.

Caaaeueiiaeciaii, ui ae?aaeaiee aeao?oeeo 1-?I ni?ey? ?icaeoeo OICE,
oiae? ye aeai? i?i ee?i?/ia cia/aiiy eiai iii??iiai aeao?oeeoo
noia?a/eea?. ?niothoue eeoa iiiaeeiie? iia?aeiieaiiy i?i caeaaei?noue
caoai?thaaiino? OA ieeiai? ao?ieia?? ? oyaeeino? eiai ia?aa?ao a?ae
??aiy 1-?I. Oiio aaaeeeaei ? ia o?eueee aea/aiiy eiai ??aiy, a ?
c’ynoaaiiy aieeao iii??iiai oa ae?aaeaiiai aeao?oeeoo ia ee?i?/iee
ia?aa?a oaeiai a?iio?oo.

Caeaaei?noue caoai?thaaiino? o?ii?/iei a?iio?oii a?ae aea?iaoiae?o?/ieo
oa?aeoa?enoee iaeueoeaaeo oa aeieiiieo oci??a aoea eeoa caii/aoeiaaia a
i?aoeyo Eeaeia?a A.?., Iaeio/aiei A.I., Cin?iiaa A.I. (1988).

A?aooaaiiy ?iaeea?aeoaeueieo niaaeeiaeo iniaeeainoae i?aai?cio, ii?yae c
?ioeie oaeoi?aie ?eceeo, aeicaieeoue nai?/anii i?iaiicoaaoe noeeuei?noue
aei aeieeiaiiy caoai?thaaiue a?iio?a oa eaaai?a o ?ia?oiee?a, ye?
i?aoeththoue o oe?aeeeaeo oiiaao, a o oai?eo — ia?aaeaa/aoe ia?aa?a
oai?iae, iniaeeaino? oneeaaeiaiue ? nei?aeooaaoe e?eoaaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Aeena?oaoe?th aeeiiaii ia aac? ee?i?/iiai a?aeae?eaiiy AeI Oa?e?anueeiai
?inoeoooo a?a??ie i?aoe? ? i?ioan?eieo caoai?thaaiue a?aeiia?aeii aei
ieaio iaoeiai-aeine?aeii? ?iaioe “Aea/aiiy aeayeeo aaiaoe/ieo oaeoi??a ?
noaio ?ioiieia?/ii? ?aaeoeaiino? i?aai?cio i?e ieeia?e iaoieia?? eaaai?a
(? aea?aeaaii? ?a?no?aoe?? A01000654?).

Iaoa ?iaioe Aecia/eoe ?ieue aeayeeo aaiaoe/ii coiiaeaieo oaeoi??a o
?icaeoeo o?ii?/iiai a?iio?oo o ?ia?oiee?a ieeiaeo i?ioan?e
iaoeiiaoaeoaaiiy aeey i?iaiicoaaiiy ?eceeo aeieeiaiiy ? ia?aa?ao oeueiai
caoai?thaaiiy, oaeineiiaeaiiy e?eoa???a i?ioa?aeai?o, cania?a
i?io?eaeoeee ? nenoaie aeeniaina?iiai iaaeyaeo ca oai?eie.

Caaea/? aeine?aeaeaiiy

1. Aea/eoe aioeaaie a?noinoi?nieoeoaa HLA o oai?eo o?ii?/iei a?iio?oii
?ia?oiee?a ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy.

2. Ioe?ieoe iieacieee aea?iaoiae?o?ee i?e o?ii?/iiio a?iio?o? o
?ia?oiee?a iaoeiiaoae?aii? i?iieneiaino?.

3. Aeine?aeeoe ci?ie ai?noo a ieaci? e?ia? 1-?ia?a?oi?a i?ioa?iac i?e
o?ii?/iiio a?iio?o? a ?iai/eo ieeiaeo i?ioan?e.

4. Ioe?ieoe cia/ou?noue eiaeiiai c aea/aieo aaiaoe/ieo oaeoi??a aeey
i?iaiicoaaiiy ?eceeo aeieeiaiiy o?ii?/iiai a?iio?oo, oyaee?noue ia?aa?ao
oai?iae o ?ia?oiee?a ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy.

5. Oaeineiiaeeoe e?eoa??? i?ioa?aeai?o a ieeia?e i?ioan??, i??e
i?io?eaeoeee caoai?thaaiiy e nenoaio aeeniaina?iiai iaaeyaeo i?e
o?ii?/iiio a?iio?o? c o?aooaaiiyi ?iaeea?aeoaeueieo iniaeeainoae
i?aai?cio.

Iaoeiaa iiaecia ?iaioe

Anoaiiaeaia ?ieue aieiaieo aiaeiaaiieo, aaiaoe/ii coiiaeaieo oaeoi??a, o
?icaeoeo o?ii?/iiai a?iio?oo o ?ia?oiee?a ieeiaeo i?ioan?e
iaoeiiaoaeoaaiiy.

I?iaaaeaii aea/aiiy eiiieaena aaiaoe/ieo (aioeaaie nenoaie HLA, 1-?I,
aea?iaoiae?o?/i? iieacieee) ? iaaaiaoe/ieo oaeoi??a ?eceeo e anoaiiaeaii
?o aieea ia aeieeiaiiy ? ee?i?/iee ia?aa?a OA o ?ia?oiee?a ieeiaeo
i?ioan?e iaoeiiaoaeoaaiiy.

Aeiaaaeaii, ui aioeaaiaie-ia?ea?aie nenoaie HLA noeeueiino? aei OA
ieeiai? ao?ieia?? ? aioeaaie HLA — A1, B12, C3, C5, aaieioei A1A8 ?
noi?aoeie A1B35C4 ? A2B35C4. I?ioaeoeai? aeanoeaino? iathoue aioeaaie
A28, A5, A22 ? aaieioei A28A35.

Anoaiiaeaii aenieo iioe?ai?noue aioeaai?a HLA — A1, A9, A10 oa aaieioeio
A1A8 i?e aaaeeeo oi?iao OA, a i?e oneeaaeiaiiyo anoiaoe/iei neiae?iiii
/e aio?caiith eaaai?a — aioeaai?a A1, A2, B7, B16, A21, A51, N2 , N3, N5
oa aaieioei A1A8.

Aeyaeaii ca’ycie i?ae caoai?thaai?noth ? ee?i?/iei ia?aa?aii OA oa
nooiaiai ae?aciino? ianoa/? 1-?I (iii??iiai, ae?aciiai). Aeiaaaeaii, ui
na?aae oai?eo ia OA iaea?eueoo aaao neeaee iniae c ae?aciei (iaioa ca
50% a?ae ii?ie) aeao?oeeoii 1-?I. Oai?? c ae?aaeaiei aeao?oeeoii 1-?I o
a?eueoino? iaee oyaeeo (III) noaae?th oai?iae, cia/io /anoioo
caaino?aiue (o?e oa a?eueoa ia ??e). O 71% oai?eo c ianoa/ath 1-?I
?icaeaaeany aio?caia eaaai?a.

Anoaiiaeai? cia/i? a?aei?iiino? aea?iaoiae?o?/ieo iieaciee?a o oai?eo ia
OA i?aoe?aiee?a iaoeiiaoaeoaaiiy ii??aiyii ?c caei?iaeie iniaaie.

I?aeoe/ia cia/aiiy ?iaioe

?ic?iaeaii iiaa ??oaiiy aeooaeueii? iaoeiai? caaea/? uiaei ciaioaiiy
/anoioe ?iciianthaeaeaiiy o?ii?/iiai a?iio?oo o ?iai/eo ieeiaeo i?ioan?e
iaoeiiaoaeoaaiiy oeyoii ioe?iee iniiaieo, aaiaoe/ii iaoiiaeaieo oaeoi??a
?eceeo, ui aeicaieythoue ia?aaeaa/aoe aeieeiaiiy ? ee?i?/iee ia?aa?a OA,
ye?nii i?iaiaeeoe i?ioa?aea??, oaeineiiaeeoe caoiaee i?io?eaeoeee
caoai?thaaiiy e nenoaio aeeniaina?iiai iaaeyaeo ca oaeeie oai?eie.

Iaa?oioiaaii ?aeiiaiaeaoe??, ui aeicaieythoue a?eueo ye?nii i?iaiaeeoe
iiia?aaei? oa ia??iaee/i? iaaee/i? iaeyaee, a oaeiae cai?iiiiiaaii
e?eoa??? c iie?auaiiy aeeniaina?iiai iaaeyaeo ca oai?eie ia OA c
o?aooaaiiyi ?o ?iaeea?aeoaeueieo iniaeeainoae.

Cai?iiiiiaai? e?eoa??? aeyaeaiiy noeeueiino? aei ?icaeoeo OA, eiai
ee?i?/ieo iniaeeainoae iiaeooue aooe aeei?enoai? i?e i?iaaaeaii?
ia??iaee/ieo ? i?io?eaeoe/ieo iaaee/ieo iaeyae?a ?ia?oiee?a, a oaeiae
aeey ye?niiai aeeniaina?iiai iaaeyaeo ca ieie.

?acoeueoaoe iaoeiaeo aeine?aeaeaiue ai?iaaaeaeaii a iaa/aeueiee i?ioean
eaoaae? a?a??ie oa i?ioan?eieo caoai?thaaiue, ee?i?/ii? eaai?aoi?ii?
ae?aaiinoeee Oa?e?anueeiai ?inoeoooo oaeineiiaeaiiy e?ea??a, a oaeiae o
i?aeoe/io ?iaioo ee?i?/iiai a?aeae?eaiiy AeI Oa?e?anueeiai IAe? a?a??ie
i?aoe? ? i?iocaoai?thaaiue, iaaeeei-nai?oa?ieo /anoei i?no Oa?eiaa,
Ieeiea?aa, Caii??aeaey, iaeanii? ee?i?/ii? e?ea?i? i. Oa?niia.

Iniaenoee aianie aeena?oaioa a ?ic?iaeo iaoeiaeo ?acoeueoao?a Aeena?oaio
aaciina?aaeiuei i?iaiaeea ee?i?/ia ianoaaeaiiy oai?eo oa ?ao?iniaeoeaiee
aiae?c ?o ?noi??e oai?ia, aiaoeaoi?ieo ea?o, aeaieo
nai?oa?ii-a?a??i?/ieo ianoaaeaiue ?iai/eo i?noeue; ?ic?iaea
niaoe?ae?ciaaio ?ioi?iaoe?eio ea?oo oai?iai ia o?ii?/iee a?iio?o,
aeeiiaa aeine?aeaeaiiy uiaei anoaiiaeaiiy aioeaai?a nenoaie HLA a
ianoaaeaieo, i?ia?a aea?iaoiae?o?/ia aeine?aeaeaiiy, ocaaaeueiaiiy,
noaoenoe/io ia?iaeo oa ?ioa?i?aoaoe?th i?aenoie?a iaea?aeaieo aeaieo.

Ai?iaaoe?y ?iaioe Iniiai? iieiaeaiiy aeena?oaoe?? aeiiia?aeaeeny ia
iaoeiai-i?aeoe/i?e eiioa?aioe?? iieiaeeo a/aieo Oa?e?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a (1994), neiiic?oi?, i?enay/aiiio 150-??//th
eaoaae?e oaeoeueoaonueei? oa?ai?? Oe?a?inueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo i. Ee?aa (1994) oa ia iaoeiai-i?aeoe/i?e eiioa?aioe??,
i?enay/ai?e 75-??//th naiai?aeneoaeae Oe?a?ie (i. Oa?e?a, 1997).

Ioae?eaoe?? : ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 15 ?ia?o, c ieo 1
— a iaoeiaiio aeo?iae? aeeaeiueiai ca?oa?aeaey, 12 — o ca??ieeao
iaoeiaeo i?aoeue, 2 — a iaoa??aeao ? oacao c’?cae?a, eiioa?aioe?e.
Aeaeai? iaoiaee/i? ?aeiiaiaeaoe?? IIC Oe?a?ie.

No?oeoo?a oa ianya ?iaioe

?iaioa aeeiiaia ia 165 noi??ieao iaoeiiieniiai oaenoo, ?ethno?iaaia 29
oaaeeoeyie (ianya – 32 noi?.), neeaaea?oueny c anooio, 5 ?icae?e?a, ui
i?noyoue iaeyae e?oa?aoo?e, ?acoeueoaoe aeanieo niinoa?aaeaiue,
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e oa nieneo e?oa?aoo?e, yeee i?noeoue
228 aeaea?ae (ianya – 30 noi?.).

CI?NO ?IAIOE

IAOA??AEE ? IAOIAeE AeINE?AeAEAIIss

Ia’?eoii aeine?aeaeaiiy aoee 134 oai?eo ia o?ii?/iee a?iio?o ?ia?oieea
ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy, na?aae yeeo 107 (79,9%) /ieia?e?a oa
27 (20,1%) ae?iie. Oai?? ia OA ii i?ioan?ei?e iaeaaeiino? aoee aeae?eai?
o 3 a?oie: iaoaeiia?iaieee (15%), aeaeo?icaa?ieee (37,3%), eeaa?ieee
(47,7%). Eiio?ieueio a?oio neeaee 137 caei?iaeo in?a — ?iai/eo iaieeiaeo
i?ioan?e.

Aea/aiiy aioeaai?a a?noinoi?nieoeoaa HLA i?iaiaeeeiny ca iaoiaeii
P.Terasaki c aeei?enoaiiyi noaiaea?oiiai i?e?ie?ioioeeoioiene/iiai oanoo
NIH. Aea/aeeny aaie aieiaiiai eiiieaeno a?noinoi?nieoeoaa o?ueio eieon?a
— A, A ? N. Aeey HLA-oeioaaiiy aeei?enoiaoaaeeny ne?iaaoee c eieaeoe??
Naieo-Iaoa?ao?cueeiai IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia?.

Noaoenoe/io ia?iaeo aeaieo i?iaiaeeee ca caaaeueiii?eeiyoeie o ee?i?/i?e
?ioiieia?? noaiaea?oieie iaoiaeaie. Aiie aeeth/aee anoaiiaeaiiy /anoioe
aioeaaia, e?eoa??th 2, a?aeiiniiai ?eceeo (RR), ao?ieia?/ii? o?aeoe??
(), aeinoia??i?noue a?aei?iiinoae (?), yeo ia/enethaaee ca oaaeeoeath 2
ia i?aenoaa? o?aooaaiiy iaeiiai nooiaiy naiaiaee.

Aecia/aiiy ??aiy 1-?I i?iaiaeeee oi?o?eiaaiei iaoiaeii A.O.Ia?oeeiai? oa
O.N.Iano?ii?, caniiaaiei ia aca?iiae?? ?ia?a?oi?a c o?eineiii o
i?enooiino? iecueeiiieaeoey?iiai noano?aoo N—aaic?e-L-a?a?i?i-aoeeiaiai
ao??o. Aeoeai?noue 1-?I aecia/aee ii aaeueioaaiith a?a?i?i-anoa?acii?
aeoeaiino? o?eineio, ?icaaaeaiiai o 50 ?ac?a ne?iaaoeith e?ia?
ianoaaeaiiai iaoe??ioa. Aeoeai?noue 1-?I ae?aaeaee /eneii oiiaieo
?ia?a?oi?ieo iaeeieoeue (?I) o 1 ie ne?iaaoee e?ia?, aa?o/e ca
iaeeieoeth ?ia?a?oi?ii? ae?? oaeo e?euee?noue ?ia?a?oi?a, yea aaeueio?
aeoeai?noue iaei??? iaeeieoe? o?eineio.

I?e aea?iaoiae?o?/ieo aeine?aeaeaiiyo aeei?enoiaoaaee iaoiaeeeo
H.Cummins, C.Midlo (1961) c o?aooaaiiyi oi?o?eiaaii? Eiiaeiinueei?
eeaneo?eaoe?? c aea?iaoiae?o?ee (D.Loesch, 1969). A?aeaeoee aiae?coaaee
ca 43 e?euee?nieie oa ye?nieie iieacieeaie aeey i?aai? oa e?ai? ?oe
ie?aii e noia?ii. Ia?iaeo iaea?aeaieo aeaieo cae?enithaaee ca e?eoa??yie
Nouethaeaioa ? O?oa?a.

?ACOEUeOAOE AeINE?AeAEAIIss OA ?O IAAIAI?AIIss

Ca?aeii c ee?i?/iith eeaneo?eaoe??th na?aae ?iai/eo ieeiaeo i?ioan?e
iaoeiiaoaeoaaiiy oai?? c I noaae??th neeaee 15,6%, c II — 59%, c III —
25,4%.

O a?eueoino? oai?eo (68 4,8%, ? < 0,001) OA ?icaeioany i?e noaae? ?iaioe a oiiaao ae?? ieeo i?ney 15 ?ie?a. Oaeaeei ?icaeaaeeny caoai?thaaiiy eeoa o 1,5% oai?eo (noaae ?iaioe a ieeiaeo oiiaao aei 5 ?ie?a). Caoai?thaaiiy iaee iia?eueiee ii/aoie ? o?ii?/iee ia?aa?a. I?e an?o noaae?yo OA oai?? nea?aeeeeny ia eaoaeue, oa?eioeiiy oa caaeeoeo. Aeey ia?oi? noaae?? oai?iae aoee oa?aeoa?i? iaae?aci? nea?ae ia nooee eaoaeue (822%) c aeae?eaiiyi iaaaeeei? e?eueeino? (aei 10 ie) oa?eioeiiy. Caaeeoea c’yaeyeany eeoa i?ney cia/iiai o?ce/iiai iaaaioaaeaiiy. I?e ianoaaeaii? – ia?eooi?ii o 7610% (? < 0,001) oai?eo aeyaeyany eaaaiaaee caoe c eaaeei ei?iaeiaei a?aeo?ieii o ieaeiueiaieiaeo a?aeae?eao, i?ae /an caaino?aiiy aeneooiaoaaeeny noo? o?eie ia oii? iineaaeaiiai aeeoaiiy. Aaioeeyoe?eia caeaoi?noue eaaai?a aoea cieaeaia o?eueee o o?aoeie oai?eo ca oaeeie iieacieeaie, ye AE?E, %IAE?E ? IOA1/AE?E (?iaeaen Oeoii). Iniaeea?noth caoai?thaaiiy OA o ?ia?oiee?a ieeiaeo i?ioan?e aoei oa, ui i?e ii/aoeiaeo noaae?yo o aeayeeo oai?eo a?aei?/aeeny oae? oneeaaeiaiiy, ye iacia/ii ae?aaeaiee anoiaoe/iee neiae?ii oa aio?caia eaaai?a. O oai?eo ?c ae?oaith noaae??th OA, i?aoethth/eo o ieeiaeo i?ioan?yo iaoeiiaoaeoaaiiy, iniiai? nea?ae oa neiioiie aoee a?eueo iino?eieie ? ae?acieie. Eaoaeue c aeae?eaiiyi oa?eioeiiy (20-30 ie) niinoa??aaee o 376% oai?eo. O /anoeie iaoe??io?a (225%) oa?eioeiiy aoei neeciai-ai?eiei. I?e iii??iiio o?ce/iiio iaaaioaaeaii? o 785% oai?eo c’yaeyeany caaeeoea (i?ioe 3811% i?e I noaae??, ? < 0,001). O iaoe??io?a oe??? noaae?? aeyaeyeenue ae?ioe?aiic (84,44%), ci?ie oi?ie i?aoae oa iaeueoe?a, a?oaeii? ee?oeie. Ia?eooi?ii o an?o oai?eo aoa ci?iaiee eaaaiaaee caoe. Ei?iaeiaee a?aeo?iie cono??/aany o 255% oai?eo ? ia niinoa??aaany i?e ia?o?e noaae??, i?ineooiaoaaeenue noo? o?eie. A oe?e a?oi? cono??/aeeny iciaee eaaaiaaiai na?oey, a oaeiae iaaeinoaoi?noue e?iaiia?ao I-IIa (o 225%) oa IIA-A nooiaith (o 436%). I?ia?anoaaiiy caoai?thaaiiy noi?iaiaeaeoaaeiny ia?iuoaaiiyi ii?ooaiiy ciai?oiueiai aeeoaiiy. I?e ae?oa?e noaae?? caoai?thaaiiy a 1,6 ?ace /ano?oa ae?aaiinooaaee 1 nooi?iue aio?caie eaaai?a (? < 0,05) oa a 3 ?ace - ae?oao nooi?iue (? < 0,001) ii a?aeiioaiith aei I noaae?? OA, a oaeiae a?eueo aaaeeo nooi?iue anoiaoe/iiai neiae?iio ( o 1,9 ?ac?a, ? < 0,05). O?aoy noaae?y oa?aeoa?ecoaaeany oyaeeei ia?aa?aii ? a?eueo ae?acieie neiae?iiaie. Oai?eo oo?aoaaa iino?eiee eaoaeue ?c aeae?eaiiyi neeciai-ai?eiiai oa?eioeiiy aei 30 ie oa a?eueoa ia aeaiue (478%). O?eueee a oe?e noaae?? caoai?thaaiiy niinoa??aaeeny aeiaaeee aeae?eaiiy ai?eiiai oa?eioeiiy. O oe?e a?oi? cia/ii a?eueoa e?euee?noue oai?eo, yeeo oo?aoaaea caaeeoea i?e iacia/iiio o?ce/iiio iaaaioaaeaii? ? a niiei? (718% i?ioe 134 i?e II noaae??, ? < 0,001). I?e ia’?eoeaiiio iaeyae? aeinoia??ii /ano?oa aeyaeyany ae?aaeaiee oe?aiic (268% i?ioe 63% i?e II noaae??, ? < 0,05), a oaeiae ci?ie oi?ie a?oaeii? ee?oeie. O aaaaoueio iaoe??io?a aiia aoea ai/eiiiae?aiith (328% i?ioe 52% i?e II noaae??, ? < 0,05). Ia?eooi?ii a iieiaeie oai?eo aecia/aee ei?iaeiaee caoe iaae on??th iiaa?oiath eaaai?a. I?aeoe/ii o an?o aeneooiaoaaee noo? (688%) oa aieia? (298%) o?eie. O oai?eo oe??? a?oie aeinoia??ii /ano?oa niinoa??aaee ae?aaeai? iciaee eaaaiaaiai na?oey (o 386% i?ioe 114% i?e II noaae??, ? < 0,05). A?eueoa i?ae o iieiaeie iaoe??io?a anoaiiaeaii iaaeinoaoi?noue e?iaiia?ao IIA-A (539%, ? < 0,05). Ooieoe?y ciai?oiueiai aeeoaiiy aoea ii?ooaia o an?o oai?eo. Oneeaaeiaiiy anoiaoe/iei neiae?iiii oa aio?caiith eaaai?a i?e oe?e noaae?? OA aoee iaea?eueo ae?acieie. *anoioa anoiaoe/iiai neiae?iio ca?eueoeeany c 52% i?e I noaae?? aei 94%. O 569% oai?eo aeyaeaia aio?caia ae?oaiai nooiaiy. Aeaye? a?aei?iiino? a ee?i?/ieo aa??aioao ia?aa?ao OA anoaiiaeaii o i?aoethth/eo ??cieo ieeiaeo i?ioan?e. Oae, o eeaa?iee?a ia?aaaaeaee oyaee? oi?ie OA c ae?acieie i?iyaaie anoiaoe/iiai neiae?iio (36%) e aio?caie (64%). Na?aae aeaeo?icaa?iee?a ia?aaaaeaee iaoe??ioe c iii??iei anoiaoe/iei neiae?iiii (387%). O 25% oai?eo iaoaeiia?iaiee?a anoiaoe/iee neiae?ii aoa a?aenooi?e, a o 20% a?i iinea iii??iee oa?aeoa?. Ao?i, o oe?e i?ioan?ei?e a?oi? oai?eo a?eueo /anoi cono??/aeany anoia (158%), ye ? o eeaa?iee?a aa?y/eo i?ioan?e (1410%). O o?aoeie iaoaeiia?iaiee?a, oai?eo ia OA, aio?caia eaaai?a ia niinoa??aaeanue. Na?aae eeaa?iee?a ? aeaeo?icaa?iee?a aeinoia??ii /ano?oa niinoa??aaeanue aio?caia I nooiaiy (a?aeiia?aeii 566% oa 587%, i?ioe 2510% o iaoaeiia?iaiee?a, ? < 0,001). O eeaa?iee?a aa?y/eo i?ioan?e OA /ano?oa oneeaaeithaaany ianiaoeeo?/iei caiaeueiei i?ioeanii, ia?aa?aaa a?eueo oyaeei, c /anoei caaino?aiiyi i?ioyaii ?ieo. A?aoiaoth/e, ui iaaia cia/aiiy o ?icaeoeo OA ieeiai? ao?ieia?? ia? ? niaaeeiaa noeeuei?noue aei caoai?thaaiue i?aai?a aeeoaiiy, iaie i?iaaaeaii aea/aiiy /anoioe iioe?aiiy aioeaai?a HLA i?e OA e o eiio?ieuei?e a?oi?. ?acoeueoaoe iaaaaeaii a oaaeeoe? 1. Oaaeeoey 1 ?iciiae?e HLA aioeaai?a o oai?eo ia o?ii?/iee a?iio?o ? caei?iaeo in?a (Psp%) Aioeaaie HLAOai?? ia OA Caei?ia? iniaeAioeaaie HLAOai?? ia OA Caei?ia? iniae A1 33,35** 10,03 A16 8,603 4,302A255,5657,64A176,1034,302A319,7422,64A1817,2421,81A917,2429,94A217, 4033,601A1022,2521,13A223,7028,002*A1117,2+410,93A279,8038,002A192,4025, 802A3519,7427,04A243,7030,002A370,0010,701A250,0010,701A380,0014,302A260 ,0011,401A390,0010,701A280,00118,93**A407,40+35,102A293,7022,102A416,103 6,502A306,1035,102A514,90+21,401A313,7020,002A560,0011,401A57,40319,73*N 12,5025,102A717,2+412,43N218,5410,93A816,0410,93N323,4510,93A1228,45**17 ,53N422,2318,23A1313,5411,63N57,4030,001A147,4038,002N60,0010,701A156,10 25,102 I?ei?oea: * - ? < 0,05, ** - ? < 0,001 - ??cieoey aaee/ei aeinoia??ia i?ae oai?eie ia OA oa caei?iaeie O oai?eo ia OA o eieonao A, A oa N aeyaeaii 33 aioeaaia HLA, a o caei?iaeo in?a - 38, aea noaoenoe/ii aeinoia??ieie ia?ea?aie noeeueiino? /e no?eeino? aei OA, a oaeiae coiiaethth/eie oa?aeoa? ia?aa?ao caoai?thaaiiy ? 9 aioeaai?a oa ?o niieo/aiue: A1, A28, A5, A12, A22, N3, N5, A1A8, A28A35 (oaae. 2). Oaaeeoey 2 *anoioa aeyaeaiiy ia?ea??a noeeueiino? oa no?eeino? aei o?ii?/iiai a?iio?oo o oai?eo oa caei?iaeo in?a Aioeaaie, AaieioeieCaei?ia?, % Oai??, % 2 RR ? A1 10,0 27,2 12,7 4,5 0,26 0,001A12 17,5 25,9 3,6 1,9 0,13 0,05N3 10,2 23,4 6,9 2,7 0,20 0,01N5 - 7,4 10,4 74 0,07 0,005A28 19,0 - 17,4 0,0 0,00 0,001A5 19,7 7,4 16,0 0,3 0,00 0,02A22 8,0 1,2 4,5 0,1 0,00 0,05A1A8 2,9 14,0 9,0 5,5 0,20 0,01A28A35 6,8 8,0 6,8 0,0 0,00 0,05 Na?aae oai?eo ia OA ?ia?oiee?a ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy a?aecia/a?oueny aeniea /anoioa aioeaai?a HLA - A1, A12, N3, N5, A1A8. O iin??a oeeo aioeaai?a a?aeiiniee ?ecee caoai?thaaiiy (RR) neeaa a?aeiia?aeii 4,5; 1,9; 2,7; 74 oa 5,5 i?e aenieiio nooiaith aeinoia??iino?. Iaeii/anii na?aae oai?eo niinoa??aaeiny nooo?aa cieaeaiiy /anoioe aioeaai?a HLA - A5, A22 oa aaieioeio A28A35, a oaeiae a?aenooi?noue aioeaaia A28, ui aea? iiaeeea?noue oea o?aeooaaoe ye caeaoi?noue ?o aei ?aae?caoe?? i?ioaeoeaiiai aoaeoo aei ?icaeoeo OA. Iieaciee a?aeiiniiai ?eceeo caoai?thaaiiy o oeeo aioeaai?a aoa ??aiee 0 aai iaaeeaeaany aei iueiai. Iniaeeai ne?ae a?aecia/eoe iin??a aioeaaio A28. Ca ?iciianthaeaeaiiyi na?aae caei?iaeo in?a a?i iin?aea? 6 i?noea (19%), iaeiae aeiaeai iin?e oeueiai aioeaaio ia aoa aeyaeaiee na?aae in?a, ui caoai??ee ia OA a?ae ae?? eiiieaeno ae?iaie/eo oaeoi??a. Aeyaeai? aeaye? iniaeeaino? ?iciiae?eo aioeaai?a HLA o ca’yceo ?c ee?i?/ieie i?iyaaie oai?iae. A?aecia/aii aenieo /anoioo niinoa??aaiiy aioeaai?a HLA - A1, A9, A10 oa aaieioeio A1A8 (?< 0,05) i?e aaaeeeo oi?iao OA. Ui??/i? iiaoi?i? caaino?aiiy, ui iio?aaoaaee noaoe?iia?iiai e?eoaaiiy, /ano?oa niinoa??aaeeny o oai?eo-iin??a aaieioeio HLA - A1A8 (? < 0,05). Ii??aithth/e /anoioo aioeaai?a HLA o oai?eo ?c iaoneeaaeiaieie oi?iaie OA oa c oneeaaeiaiei anoiaoe/iei neiae?iiii ? aio?caiith eaaai?a, anoaiiaeee, ui an? aioeaaie c aenieei anioe?aoeaiei ca’yceii ?c caoai?thaaiiyi OA (RR=2) iathoue e aeinoia??iee ca’ycie ?c ?icaeoeii anoiaoe/iiai neiae?iio oa aio?caie eaaai?a. A?eueo oiai, /ei aeuei ? eiao?oe??io anioe?aoe??, oei a?eueoo ieoiio aaao o oai?eo c oneeaaeiaiiyie caeiaa a?aeiia?aeiee aioeaai nenoaie HLA. Oae, o an?o oai?eo ia OA, oneeaaeiaiee anoiaoe/iei neiae?iiii, aeyaeaii aioeaaie N5, A51, A1A8, a eiao?oe??io anioe?aoe?? a?aeiia?aeii neeaa: 74; 5,5; 3,5. ??cieoey a ii??aiyii? c oai?eie aac oneeaaeiaiue anoiaoe/iei neiae?iiii aeinoia??ia (? < 0,001). Ii?yae ?c aeacaieie aioeaaiaie i?e oneeaaeiaiiyo anoiaoe/iei neiae?iiii aeineoue /anoi cono??/aeeny aioeaaie A1 (893%, ? < 0,001, RR=4,5), A11 (864%, ? < 0,001, RR=1,7), A16(844%, ? < 0,05, RR=2,1) ? N2(804%, ? < 0,05, RR=1,9). I?e ii?aeiaii? OA c aio?caiith eaaai?a o a?eueoino? aeiaaee?a ciaoiaeeee o? ae nai? aioeaaie HLA - A1, A11, A7, A12, A21, N3 oa aaieioei A1A8. Aeeeth/aiiy neeaa aioeaai N5, yeee iaa neeueiee anioe?aoeaiee ca’ycie c anoiaoe/iei neiae?iiii ? ia iaa aeinoia??ii? anioe?aoe?? c aio?caiith eaaai?a. Aioeaaie HLA iaee ??cio /anoioo aeyaeaiiy a a?oiao oai?eo c ??ciith i??ith ae?aciino? caiaeueiiai i?ioeano a a?iio?aeueiiio aea?aa?. Iin??a aioeaai?a A1(784%, ? < 0,001), A7 (675%, ? < 0,05), N3 (794%, ? < 0,001), N5 (1001%, ? < 0,001) ? aaieioeio A1A8 (913%, ? < 0,001) /ano?oa oo?aoaaa iino?eiee eaoaeue, yeee o iin??a aioeaai?a A1 ? A12 aeinoia??ii /ano?oa noi?iaiaeaeoaaany aeae?eaiiyi neeciai-ai?eiiai oa?eioeiiy ii??aiyii c iin?yie ?ioeo aioeaai?a. Oyaee? oi?ie caaeeoee (a niiei? oa i?e iii??iiio iaaaioaaeaii?) /ano?oa niinoa??aaee na?aae iin??a aioeaaio A1 (305%, ? < 0,001). Oea aoa ?aeeiee aioeaai, i?e iayaiino? yeiai oai?? nea?aeeeenue ia oyaeeo oi?io eaoeth c oa?eioeiiyi, caaeeoeo. I?e aea/aii? 1-?I ye oaeoi?o ?eceeo OA o i?aoe?aiee?a ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy caa?oaeany oaaaa ia ?ieue nooiaiy ae?aciino? aeao?oeeoo: ae?aciiai (iaioa 50%), iii??iiai (aei 50% ii?ie). ?acoeueoaoe iaoeo aeine?aeaeaiue iieacaee, ui aeinoia??ii /ano?oa a iaoe??io?a niinoa??aaee ae?acio ianoa/o ai?noo 1-?I (415%, ? < 0,001), iii??io - aeyaeaii o 355% oai?eo. Anoaiiaeaii, ui /ei aaae/a aoa ia?aa?a caoai?thaaiiy, oei a?eueoei aoa aeao?oeeo 1-?I. I?e II noaae?? eiai ai?no aoa aeinoia??ii ieae/ee, i?ae o caei?iaeo in?a , ? neeaaeaa 15,72,4 ?I/ie, a i?e III noaae?? - 14,72 ?I i?ioe 21,61,9 ?I o caei?iaeo (? < 0,05). Ieoiia aaaa iaoe??io?a ?c ae?aciei aeao?oeeoii 1-?I aoea oei a?eueoith, /ei oyae/ith aoea oi?ia OA. I?e III noaae?? caoai?thaaiiy 45% oai?eo iaee eiai ae?aciee aeao?oeeo (? < 0,001). I?e iii??iiio - oaei? /?oei? caeaaeiino? i?ae noaae?yie oai?iae ia i?inoaaeoaaeinue. Eeoa i?e II noaae?? OA oieneei-ieeiai? ao?ieia?? 467% oai?eo iaee iii??iee aeao?oeeo i?ioe 3711% o eiio?ieuei?e a?oi? (? < 0,01). Caaaeueiia?aeiii, ui ianoa/a 1-?I coiiaeth? i?aeaeuaio noeeuei?noue aei ?icaeoeo aio?caie eaaai?a, ui i?aeoaa?aeaeo?oueny e iaoeie aeine?aeaie. O a?oi? oai?eo c oneeaaeiaiiyie aio?caiith eaaai?a, ii??aiyii ?c caei?iaeie, anoaiiaeaii ciaioaiiy ??aiy 1-?I o ne?iaaooe? e?ia? ( o 71% oai?eo) , o oiio /ene? o 255% aeiaaeeao oea cieaeaiiy aoei aeinoia??ii ae?aciei ? a 466% - iii??iei (? < 0,05). A?aecia/aii ci?ie ??aiy 1-?I a?ae i?aae’yaeaieo nea?a. O oai?eo ia OA ieeiai? ao?ieia??, ui no?aaeaeathoue caaeeoeith a niie?eiiio noai? aai i?e iacia/iiio o?ce/iiio iaaaioaaeaii?, ??aaiue 1-?I o ne?iaaooe? e?ia? neeaaeaa 12,92 ?I/ie i?ioe 21,61,9 ?I/ie, ? < 0,01. O oai?eo c oyaeeith caaeeoeith ae?acia ianoa/a niinoa??aaeany o 48% aeiaaee?a (? < 0,001), a o 35% - aiia aoea iii??iith. Oai?? c ia??iaee/iei oa iino?eiei eaoeai iaee aeinoia??ii iecuee? iieacieee ai?noo 1-?I ii??aiyii ?c eiio?ieueiith a?oiith (? < 0,05). O iieiaeie iaoe??io?a c ia??iaee/iei oa iino?eiei eaoeai anoaiiaeaii ae?aciee aeao?oeeo 1-?I (? < 0,05 ? ? < 0,001). O aeiaaeeao, eiee eaoaeue noi?iaiaeaeoaaany aeae?eaiiyi neeciai-ai?eiiai oa?eioeiiy, a?aecia/aee a?eueo ae?acio ianoa/o 1-?I, /ei i?e aeae?eaii? neeciaiai oa?eioeiiy. Aeinoia??ii? caeaaeiino? e?euee?niiai aeae?eaiiy oa?eioeiiy a?ae ??aiy 1-?I ia ciaeaeaii. *ei /ano?oa niinoa??aaeeny caaino?aiiy OA, oei iaioei aoa ??aaiue 1-?I o ne?iaaooe? e?ia? oai?eo. Iaea?eueo cia/iee aeao?oeeo eiai aoa o oai?eo, ui iaee o?e oa a?eueoa caaino?aiiy ia ??e (13,13,2% , ? < 0,05). O oe?e a?oi? iieiaeia oai?eo iaea ae?acio iaaeinoaoi?noue ai?noo 1-?I (? < 0,001) ? 38% - iii??io. Aea/ath/e niaaeeiao noeeuei?noue i?e OA iaoiaeii aea?iaoiae?o?ee , anoaiiaeee a?aei?iiino? a oa?aeoa?? oa ?ioaineaiino? iieaciee?a ii??aiyii ?c caei?iaeie iniaaie. Anoaiiaeaii, ui o oai?eo OA ia 4 oa 5 iaeueoeyo e?ai? ?oee aeyaeaii aeoae, a ia 5 iaeueoe? i?aai? - ?aae?aeuei? iaoe?, a oie /an ye o eiio?ieuei?e a?oi? ?o iaia?. Ia 1 iaeueoe? aeoae cieeathoue, o oie /an ye o in?a eiio?ieueii? a?oie aiie cono??/aeeny. A?aecia/aii noaa?euei?noue ???a?o?/ii? /anoioe oeueia?ieo iaoaeue oa caaeoe?a. Ia an?o iaeueoeyo, ye e?ai?, oae ? i?aai? eeno?, oa ia 4 iaeueoe? e?ai? caaeoee ia?aaaaeaee iaae oeueia?ieie iaoeyie, W >
LR, a ia ?aoo? iaeueoe?a LR > W.

C iniaeeainoae aeieiiiiai iaethieo oe??e a?aecia/aee aenieo /anoioo ci?i
oi?ioee o?e?aae?on?a o oai?eo ii??aiyii ?c caei?iaeie (80,33% ? 505%, ?
< 0,001). O oai?eo ia OA aeinoia??ii /ano?oa niinoa??aaee ii?ooaiiy oi?ioee iaeueoeaaeo o?e?aae?on?a ? aecia/aee oci? ia e?aiio oaia??. Oaeei /eiii, i?iaaaeai? iaie aeine?aeaeaiiy iieacaee, ui a ?icaeoeo OA o ?ia?oiee?a “ieeiaeo” i?ioan?e iaoeiiaoaeoaaiiy aaaeeeaa ?ieue iaeaaeeoue oaeei aiaeiaaiiei , aaiaoe/ii coiiaeaiei , oaeoi?ai, ye iayai?noue aioeaai?a noeeueiino? eiiieaeno HLA aei caoai?thaaiiy, cieaeaiiy ai?noo 1-?I, a oaeiae oa?aeoa?i? ci?ie aea?iaoiae?o?/ieo iieaciee?a. Ne?ae a?aecia/eoe, ui cia/ii /ano?oa OA aeieeaa o in?a, aeey yeeo oa?aeoa?iei aoei niieo/aiiy oeeo oaeoi??a. Aei oiai ae oaea eiia?iaoe?y aiaeiaaiieo , aaiaoe/ii coiiaeaieo, oaeoi??a ni?eyea e a?eueo oyaeeiio ia?aa?ao caoai?thaaiiy o 61% oai?eo, ui i?aeoaa?aeaeoaaeiny aeeiai?/iei iaaeyaeii. AENIIAEE 1. Aeey i?aoe?aiee?a iaoeiiaoaeoaaiiy oa?aeoa?iei ? aeieeiaiiy o?ii?/iiai a?iio?oo ia?aaaaeii i?ney o?eaaeiai eiioaeoo ?c oe?aeeeainoyie (16 ?ie?a oa a?eueoa), yeee noi?iaiaeaeoaaany ?aii?i ii?ooaiiyi ooieoe?? ciai?oiueiai aeeoaiiy, iiyaith aio?caie eaaai?a oa anoiaoe/iiai neiae?iio. 2. Na?aae aeaeo?icaa?iee?a oa eeaa?iee?a , ia a?aei?io a?ae iaoaeiia?iaiee?a, o 85% aeiaaee?a ia?aaaaeaee aaaee? oi?ie o?ii?/iiai a?iio?oo. Oea iia’ycaii, ii?yae c ?ioeie aiaei- ? aeciaaiieie oaeoi?aie, ?o eiioaeoii c a?eueo aenieeie eiioeaio?aoe?yie ieeo (7,5 - 16,6 AAeE), iiae?acithth/eie oa aea?a?coth/eie ?a/iaeiaie (ieenai aoaeaoeth, ieenai acioo, oaiieii, oi?iaeueaeaa?aeii, ae?iea?iii, ieeneaie iaoae?a oa ?i.) , a oaeiae ae??th iani?eyoeeaeo iaoaioaeoi??a. 3. O ?ia?oiee?a ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy, iin??a aioeaai?a nenoaie HLA - A1, A12, N3, N5, aaieioeio A1A8 oa noi?aoei?a A1A35N4 ? A2A35N4, aeyaeaii aenieee aeinoia??iee anioe?aoeaiee ca’ycie ?c aeieeiaiiyi o?ii?/iiai a?iio?oo. Ia?ea?aie ?acenoaioiino? aei ?icaeoeo OA ? aioeaaie A28, A5, A22 ? aaieioei A28A35. 4. Aeey i?aoe?aiee?a, iin??a aioeaai?a A3, A9, A7, N2, N3, oa?aeoa?iei ? i?ci?e (i?ney 16 ?ie?a ieeiaiai noaaeo) ?icaeoie o?ii?/iiai a?iio?oo. O in?a c aioeaaiaie A2, A3, A8, A13, N4, N5 i?aeaeuaiee ?ecee aeieeiaiiy o?ii?/iiai a?iio?oo ieeiai? ao?ieia?? na?aaeiuei? oyaeeino?, a o iin??a aioeaai?a A1, A9, A10 oa aaieioeio A1A8 - aaaeei? oi?ie. 5. O i?aoe?aiee?a iaoeiiaoaeoaaiiy, oai?eo ia OA, ye? ? iin?yie aioeaai?a nenoaie HLA - A1, A2, A7, A16, A21, A51, N2, N3, N5 ? aaieioeio A1A8, niinoa??aathoueny /ano? oneeaaeiaiiy caoai?thaaiiy anoiaoe/iei neiae?iiii aai aio?caiith eaaai?a. 6. O i?aoe?aiee?a aa?y/eo i?ioan?e, ia a?aei?io a?ae iaoaeiia?iaiee?a, ?ecee ?icaeoeo o?ii?/iiai a?iio?oo a?eueo aenieee o in?a c aioeaaiaie A1 oa N5. O aeaeo?icaa?iee?a oeae ?ecee iia’ycaiee ua c aioeaaiaie A9, N2, aaieioeiii A1A8, a o eeaa?iee?a - c aioeaaiii A12. 7. O 2/3 i?aoe?aiee?a iaoeiiaoaeoaaiiy, oai?eo ia o?ii?/iee a?iio?o, a?aecia/a?oueny iii??ia (o 35%) aai ae?acia (o 41%) cieaeaiiy eiioeaio?aoe?? 1-?ia?a?oi?a i?ioa?iac a ne?iaaooe? e?ia?, ui oaeiae coiiaeth? a?eueo aaaeeee ia?aa?a caoai?thaaiiy (o 69%). 8. O oai?eo ia o?ii?/iee a?iio?o i?aoe?aiee?a iaoeiiaoaeoaaiiy , ia a?aei?io a?ae caei?iaeo in?a , anoaiiaeaii aeinoia??i? ci?ie iieaciee?a aea?iaoiae?o?ee , ye? oa?aeoa?ecothoueny a?eueo aenieith /anoioith oeueia?ieo iaoaeue o iaeueoeaaiio iaethieo, ae?aci?noth iaethiea ia e?aiio oaia??, ii?ooaiiyi oi?ioee o?e?aae?on?a, ciaioaiiyi /anoioe caaeoe?a oa td-ia?an?/aiino?. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aecia/aoe aioeaaie nenoaie HLA oa ai?no 1-?ia?a?oi?a i?ioa?iac a ne?iaaooe? e?ia? c iaoith i?ioa?aeai?o a in?a, ye? iinooiathoue ia ieeia? i?aei?e?inoaa. Aeyaeaiiy iayaiino? iaeiiai c aioeaai?a HLA - A1, A12, N3, N5 oa aaieioeio A1A8, a oaeiae ae?aciiai aeao?oeeoo 1-?I iiaeiii aooe i?ioeiieacaiiyi aeey i?eeiyooy ?o ia ?iaioo o ieeia? i?ioan??. 2. Aecia/aoe aioeaaie nenoaie HLA oa 1-?I na?aae aaea i?aoethth/eo ia ieeiiaaacia/ieo i?aei?e?inoaao c iaoith aeyaeaiiy in?a i?aeaeuaiiai ?eceeo aei o?ii?/iiai a?iio?oo aeey i?iaaaeaiiy na?aae ieo ?iaeea?aeoaeueieo e?eoaaeueii-i?io?eaeoe/ieo caoiae?a o i?ioean? aeeniaina?iiai iaaeyaeo. 3. A?aoiaoaaoe aeyaeai? aaiaoe/i? oaeoi?e ?eceeo o oai?eo ia o?ii?/iee a?iio?o ieeiai? ao?ieia??, a oaeiae i?e eiai oneeaaeiaiiyo aio?caiith eaaai?a ? anoiaoe/iei neiae?iiii aeey i?iaaaeaiiy oe?eani?yiiaaii? oa?ai??. NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Aeiooianeay O.I. Aeueoa-1-eiaeaeoi? i?ioaeiac e aai ?ieue i?e o?iie/aneii a?iioeoa //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - Iieoaaa-Oa?ueeia.- 1998. - ?6. - n.110-117. 2. Aeiooianeay O.I. Iniaaiiinoe eeeie/aneiai oa/aiey iueaaiai a?iioeoa o ?aai/eo iaoeiino?iaiey //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - Iieoaaa-Oa?ueeia.- 1998. - ?12. - n.102-106. 3. Aeiooianeay O.I. Aioeaaiu HLA i?e iueaaii a?iioeoa o ?aai/eo iaoeiino?iaiey //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - Iieoaaa-Oa?ueeia.- 1998. - ?12. - n.107-110. 4. Oea/ N.E., Oiooa? E.I., Iaeio/aiei A.I., O?oo A.N., Ao?aiiaa A.A., I?eeeineay I.E., Aeiooianeay O.I. Acaeiinaycue iaaeaeo aioeaaiaie nenoaiu HLA e ninoiyieai eiioieoaoa i?e iueaaie iaoieiaee eaaeeo o ?aai/eo iaoeiino?ieoaeueiie i?iiuoeaiiinoe //Iaaeeoeeia o?oaea e i?iiuoeaiiay yeieiaey.- Iineaa. - 1995. - ?8. - n.22-25. 5. Aeiooianeay O.I. ?ieue eo?aiey eae oaeoi? ?enea i?e caaieaaaieyo iueaaui a?iioeoii o ?aai/eo iaoeiino?iaiey //Iaaeeoeeineay yeieiaey. Aeaeaia i?iecaiaenoaaiiie e ie?oaeathuae n?aaeu: Na.iao/i.o?. – OIO,Oa?ueeia. - 1997. - n.156-162. 6. Aeiooianeay O.I. Iniaaiiinoe aea?iaoiaeeoeee o aieueiuo iueaaui a?iioeoii //Aeieiae/aneia aeaenoaea oaeoi?ia ie?oaeathuae n?aaeu: Na.iao/i.o?. - OIO, Oa?ueeia. - 1996. - n.83-87. 7. Aeiooianeay O.I. Eco/aiea ooieoeee aiaoiaai aeuoaiey o ?aai/eo iaoeiino?iaiey //Aeieiae/aneia aeaenoaea oaeoi?ia ie?oaeathuae n?aaeu: Na.iao/i.o?. - OIO, Oa?ueeia. - 1996. - n.87-90. 8. Aeiooianeay O.I. Auyaeaiea o?iaiy 1-EI (aeueoa-1-eiaeaeoi?a i?ioaeiac) a nuai?ioea e?iae aieueiuo iueaaui a?iioeoii //Aeieiae/aneia aeaenoaea oaeoi?ia ie?oaeathuae n?aaeu: Na.iao/i.o?. - OIO, Oa?ueeia. - 1996. - n.91-93. 9. Aeiooianeay O.E. Eiaeeaeaeoaeueiue o/ao aaiaoe/aneeo oaeoi?ia ?enea i?e i?ioeeaeoeea iueaaiai a?iioeoa o ?aai/eo iaoeiino?ieoaeueiuo i?aaei?eyoee //Iaae.yeieiaey. Aeaeaia i?iecaiaenoaaiiie e ie?oaeathuae n?aaeu: Na.iao/i.o?. - OIE, Oa?ueeia. - 1994. - n.117-120. 10. Aaoooaiei A.E., Neaei?aiei I.A., Aeiooianeay O.I., Eiaaeaiei E.E., Na?aethe N.I., Iieina O.A. Naieoa?ii-aeaeaie/aneay ioeaiea oneiaee o?oaea a naa?i/iii oeaoa iaoeiino?ieoaeueiiai caaiaea // Iaae.yeieiaey. Aeaeaia i?iecaiaenoaaiiie e ie?oaeathuae n?aaeu: Na.iao/i.o?. - OIE, Oa?ueeia. - 1994. - n.35-38. 11. Aeiooianueea O.I., Eiaaeaiei ?.?., Neaei?aiei I.I., Aauoe I.A., Na?aethe N.I., Iieina O.A. Icaei?iaeaiiy oiia i?aoe? o iaoeiiaoae?ai?e oa iaoaeiia?iai?e i?iieneiaino? o ca’yceo ?c canoinoaaiiyi II? //A?ieia?/ia ae?y o?i?/ieo niieoe oa a?a??i?/i? caoiaee: Ca.iaoe.i?. – OI?, Oa?e?a. - 1993. -n.69-73. 12. Aeiooianeay O.I. Iniaaiiinoe oneiaee o?oaea ?aai/eo iniiaiuo i?ioannee iaoeiino?iaiey, caaieaaoeo iueaaui a?iioeoii //Aeo. I?iaeaiu e iniiaiua iai?aaeaiey ?acaeoey i?ioeeaeoe/aneie iaoee e i?aeoeee. - Oac. aeiee. iaeanoi.iao/i.-i?aeo. eiioa?aioeee, iinayu. 75-eaoeth nai.neoaeau Oe?aeiu - Oa?ueeia. - 1997. - n.24-25. 13. Oiooa? E.I., Oea/ N.E., O?oo A.N., Aeiooianeay O.I. ?ieue enoiaeiiai ninoiyiey eiioiiie nenoaiu a aicieeiiaaiee iiaaiieiieica eee iueaaiai a?iioeoa o ?aai/eo iueaauo i?ioannee iaoeiino?iaiey //Aeo.aii?inu aeaeaiu o?oaea, i?ioiaoieiaee e iaae.iaania/aiey o?oaeyueony i?ii.i?aaei?eyoee ia nia?aiaiiii yoaia ?acaeoey oicyenoaaiiiai eiiieaena Aeiiaanna. - Oac.aeiee. Anaoe?aeineie iao/i.-i?aeo. eiio. n iaaeaeoi. o/anoeai, iina. 70-eao. Aeiiaoeeiai IEE aea.o?. e i?io. caaie. - Aeiiaoee. - 1995. - n.153. 14. Iaeio/aiei A.I., Eaoei E.I., I?eeeineay I.E., Ao?aiiaa A.A., Oiooa? E.I., O?oo A.N., Oea/ N.E., Aeiooianeay O.I., *a?iiaa N.Ae., Ienaithe E.I., Ia?ouiia I.I. I?ioeeaeoeea iueaauo caaieaaaiee eaaeeo n o/aoii eiaeeaeaeoaeueiuo iniaaiiinoae i?aaiecia// Aeo.aii?inu aioo?aiiae iaaeeoeeiu, iaae.yoeee e ia?aciaaiey. – Oac. aeiee. neii. iina. 150-eao. eaoaae?u oae. oa?. Oe?aeineiai ainoae.iaae.oiea. - Eeaa. - 1994. - n.16. 15. Aeiooianeay O.I. ?ieue iuee a noiia oaeoi?ia ?enea o?iie/aneiai a?iioeoa o ?aai/eo i?aaei?eyoee iaoeiino?iaiey //Iaae.yeieiaey, yieaeaieieiaey e aeaeaia ie?oaeathuae e i?iecaiaenoaaiiie n?aaeu. Iaoa?.?aaeii.iao/ii-i?aeo.eiioa?aioeee. - Oa?ueeia. - 1996. A I I O A Oe ? ss Aeiooianueea O.I. ?ieue aiaeiaaiieo, aaiaoe/ii coiiaeaieo, oaeoi??a o ?icaeoeo o?ii?/iiai a?iio?oo o ?iai/eo ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy. ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.02 - aioo??oi? oai?iae. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. O ?iaio? i?e ianoaaeaii? 134 oai?eo ia o?ii?/iee a?iio?o ?ia?oiee?a ieeiaeo i?ioan?e iaoeiiaoaeoaaiiy anoaiiaeaii, ui ?ecee ?icaeoeo o?ii?/iiai a?iio?oo, ee?i?/iee ia?aa?a caoai?thaaiiy oa eiai oneeaaeiaiue caeaaeaoue a?ae iaaieo aioeaai?a nenoaie HLA, nooiaiy ae?aciino? aeao?oeeoo 1-?I. Ia a?aei?io a?ae caei?iaeo in?a o oai?eo ia OA aeyaeaii aeinoia??i? ci?ie aea?iaoiae?o?/ieo iieaciee?a. Iaa?oioiaaii ?aeiiaiaeaoe?? uiaei aeyaeaiiy ?iaeea?aeoaeueieo, niaaeeiai-coiiaeaieo oaeoi??a ?eceeo, ye? aeicaieythoue nai?/anii i?iaiicoaaoe noeeuei?noue aei aeieeiaiiy caoai?thaaiue a?iio?a o ?iai/eo oe?aeeeaeo i?ioan?e, a o oai?eo - ia?aaeaa/aoe ia?aa?a oai?iae, iniaeeaino? oneeaaeiaiue ? nei?aaoaaoe e?eoaaiiy. Eeth/ia? neiaa: o?ii?/iee a?iio?o, ieeia? i?ioan??, HLA-aioeaaie, 1-?ia?a?oi? i?ioa?iac, aea?iaoiae?o?ea. A I I I O A Oe E ss Aeiooianeay O.I. ?ieue yiaeiaaiiuo, aaiaoe/anee iaoneiaeaiiuo , oaeoi?ia a ?acaeoee o?iie/aneiai a?iioeoa o ?aai/eo iueaauo i?ioannee iaoeiino?iaiey. ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.02 - aioo?aiiea aieacie. Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. A ?aaioa i?e ianeaaeiaaiee 134 aieueiuo o?iie/aneei a?iioeoii, ?aai/eo iueaauo i?ioannee iaoeiino?iaiey e 137 caei?iauo eeoe eiio?ieueiie a?oiiu onoaiiaeaii, /oi ?ene ?acaeoey o?iie/aneiai a?iioeoa (OA), eeeie/aneia oa/aiea caaieaaaiey e aai ineiaeiaiey caaenyo io ii?aaeaeaiiuo aioeaaiia nenoaiu HLA, noaiaie au?aaeaiiinoe aeaoeoeeoa eiaeaeoi?a i?ioaeiac (1-EI), iieacaoaeae aea?iaoiaeeoeee. Onoaiiaeaii, /oi n?aaee ?aai/eo iueaauo i?ioannee iaoeiino?iaiey aieueiua OA n I noaaeeae ninoaaeee 15,6%, ni II – 59%, n III – 25,4%. O aieueoeinoaa aieueiuo (68%) OA ?acaeeny i?e iueaaii noaaea ?aaiou aieaa 15 eao. Auno?ia ?acaeoea caaieaaaiey ioia/aii oieueei o 1,5% aieueiuo (“iueaaie” noaae – aei 5 eao). Eiaei ianoi iinoaiaiiia ia/aei e o?iie/aneia oa/aiea OA. I?e anao noaaeeyo OA iaoeeaiou i?aaeuyaeyee aeaeiau ia eaoaeue n auaeaeaieai iie?iou e iaeuoeo. Aeey ia?aie noaaeee OA oa?aeoa?iu aeaeiau aieueiuo ia nooie eaoaeue (822%) n auaeaeaieai iaaieueoiai eiee/anoaa (aei 10 ie) iie?iou. Iaeuoea iiyaeyeanue oieueei iinea cia/eoaeueiiai oece/aneiai iai?yaeaiey. I?e ianeaaeiaaiee – ia?eooi?ii o 7610% aieueiuo ii?aaeaeyeny eaai/iie caoe n eaaeei ei?iai/iui iooaieii a ieaeiaaieiauo ioaeaeao, a ia?eiae iaino?aiey auneooeaaeenue ianoieeea nooea o?eiu ia oiia ineaaeaiiiai aeuoaiey. Aaioeeyoeeiiiay niiniaiinoue eaaeeo auea ianeieueei nieaeaia o o?aoe aieueiuo ii oaeei iieacaoaeyi, eae AEAE, %AeAEAE e IOAI/AEAE (eiaeaen Oeooii). Iniaaiiinoueth caaieaaaiey OA o ?aai/eo iueaauo i?ioannee yaeyeinue oi, /oi ia ia/aeueiuo noaaeeyo ioia/aee oaeea ineiaeiaiey, eae iacia/eoaeueii au?aaeaiiue anoiaoe/aneee neiae?ii e yioecaio eaaeeo. O aieueiuo aoi?ie noaaeee OA iniiaiua aeaeiau e neiioiiu auee aieaa au?aaeaiiuie e iinoiyiiuie. A yoie a?oiia ano?a/aeenue i?eciaee eaai/iiai na?aeoea, iaaeinoaoi/iinoue e?iaiia?auaiey I-II A (225%) e II A-A noaiaie (436%). Ia?ooaiey ooieoeee aiaoiaai aeuoaiey ia?anoaee. A 1,6 ?aca /aua aeeaaiinoe?iaaee I noaiaiue yioecaiu eaaeeo, auyaeyee aoi?oth noaiaiue, a oaeaea aieueooth au?aaeaiiinoue anoiaoe/aneiai neiae?iia (a 1,9 ?aca). O?aouey noaaeey oa?aeoa?eciaaeanue oyaeaeui oa/aieai, aieueoei i?iyaeaieai neiae?iiia. A yoie noaaeee OA iaaethaeaee neo/ae auaeaeaiey aiieiie iie?iou. Ooieoeey aiaoiaai aeuoaiey auea ia?ooaia o anao aieueiuo. I?eciaee eaai/iiai na?aeoea ioia/aee o 386% aieueiuo. Aieaa /ai o iieiaeiu iaoeeaioia ioia/aee iaaeinoaoi/iinoue e?iaiia?auaiey II A-A noaiaie (539%). N?aaee aieueiuo OA iueaaie yoeieiaee /anoi ano?a/aeenue aioeaaiu nenoaiu HLA - A1, B12, C3, C5, aaieioei A1A8. O iineoaeae yoeo aioeaaiia ioiineoaeueiue ?ene ?acaeoey caaieaaaiey (RR) ninoaaee niioaaonoaaiii 4,5; 1,9; 2,7; 74 e 5,5 i?e aunieie noaiaie aeinoiaa?iinoe. Iaeiia?aiaiii n?aaee iaoeeaioia iaaethaeaeinue nouanoaaiiia nieaeaiea /anoiou aioeaaiia HLA - A5, A22 e aaieioeia A28A35, ionoonoaea aioeaaia A28, /oi iicaieyao ?anniao?eaaoue eo niiniaiuie e ?aaeecaoeee i?ioaeoeaiiai yooaeoa a ?acaeoee OA. Iieacaoaeue ioiineoaeueiiai ?enea caaieaaaiey o iineoaeae yoeo aioeaaiia aue ?aaai ioeth eee i?eaeeaeaeny e iaio. Ioia/aia aunieay /anoioa HLA – A1, A9, A10 e aaieioeia A1A8 i?e oyaeaeuo oi?iao OA. Aaeaaiaeiua /anoua iaino?aiey, o?aaothuea noaoeeiia?iiai ea/aiey iaaethaeaee o iineoaeae aaieioeia A1A8. Ana aioeaaiu n aunieie annioeeaoeaiie naycueth n caaieaaaieai (RR) eiaee aeinoiaa?ioth naycue n anoiaoe/aneei neiae?iiii e yioecaiie eaaeeo. Iineoaeae aioeaaiia A1, C3, C5 e aaieioeia A1A8 aeinoiaa?ii /aua aaniieiee eaoaeue, eioi?ue o iineoaeae aioeaaiia A1 e A12 nii?iaiaeaeaeny auaeaeaieai neecenoi-aiieiie iie?iou. Oyaeaeua oi?iu iaeuoee /aua ano?a/aee n?aaee iineoaeae aioeaaia A1. Yoi aaeeinoaaiiue aioeaai, i?e iaee/ee eioi?iai iaoeeaiou aeaeiaaeenue ia au?aaeaiiue eaoaeue n auaeaeaieai iie?iou e iaeuoeo. I?e eco/aiee 1-EI ?acoeueoaou enneaaeiaaiee iieacaee, /oi aeinoiaa?ii /aua o aieueiuo OA iaaethaeaee au?aaeaiioth iaaeinoaoi/iinoue 1-EI (415%) e oia?aiioth – o 355%. Onoaiiaeaii, /oi /ai oyaeaeaa i?ioaeaei caaieaaaiea, oai aieueoei aue aeaoeoeeo 1-EI. A a?oiia aieueiuo OA, ineiaeiaiiui yioecaiie eaaeeo, ii?aaeaeai au?aaeaiiue aeaoeoeeo 1-EI. Iaeaieaa cia/eoaeueiay iaaeinoaoi/iinoue 1-EI ioia/aeanue o aieueiuo, eiaaoeo o?e e aieaa iaino?aiee a aiae. A yoie a?oiia iieiaeia iaoeeaioia eiaea au?aaeaiioth iaaeinoaoi/iinoue 1-EI e 38% - oia?aiioth. Eco/ay ianeaaenoaaiioth neeiiiinoue e OA iaoiaeii aea?iaoiaeeoeee, onoaiiaeaiu ioee/ey a oa?aeoa?a e eioaineaiinoe aai iieacaoaeae a n?aaiaiee ni caei?iauie eeoeaie. O aieueiuo ia 4 e 5 iaeueoeao eaaie ?oee auyaeaiu aeoae, a ia 5 iaeueoea i?aaie – ?aaeeaeueiua iaoee, a oi a?aiy eae a eiio?ieueiie a?oiia iie ionoonoaiaaee. Ia anao iaeueoeao eaaie e i?aaie eenoe i?aiaeaaeaee caaeoee iaae oeueia?iuie iaoeyie, W >
LR, a ia inoaeueiuo iaeueoeao LR > W. Ec iniaaiiinoae eaaeiiiiai ?enoiea
eiaee ioia/aia aunieay /anoioa eciaiaiee oi?ioeu o?e?aaeeonia o aieueiuo
a n?aaiaiee n eiio?ieueiie a?oiiie (80,33% e 505%, p < 0,001). Ia iniiaaiee enneaaeiaaiee iainiiaaiu ?aeiiaiaeaoeee ii auyaeaieth eiaeeaeaeoaeueiuo, ianeaaenoaaiii-iaoneiaeaiiuo oaeoi?ia ?enea, eioi?ua iicaieytho naiaa?aiaiii i?iaiice?iaaoue neeiiiinoue e aicieeiiaaieth caaieaaaiee a?iioia o ?aai/eo iueaauo i?ioannee, a o aieueiuo – i?aaeoniio?aoue oa/aiea OA, aai ineiaeiaiee e nei??aeoe?iaaoue ea/aiea. Eeth/aaua neiaa: a?iioeo, iueaaua i?ioannee, HLA - aioeaaiu, 1-eiaeaeoi? i?ioaeiac, aea?iaoiaeeoeea. A N N O T A T I O N Dmuchovskaya T.N. The Role of Endogeneous, Conditioned, Hereditary Factors in the Development of Chronical Bronchitis Between Workers of Dust Professions in Mechanical Ingineering. Manuscript. Dissertation on competition of candidates degree in medical scienses on speciality 14.01.02 - Internal Diseases. Charkov Medical University, Charkov, 1998. The dependance of the risk of chronical bronchitis development, its clinical flow complications to definit HLA-system antigens, degree of expression of 1-proteinasa ingibitor deficit was determinated in the work during examination of 134 patients with chronical bronchitis. The fact that patients with chronical bronchitis, as distinct from has certain changes of dermatoglyfical indices was elicit. Recomendations on exposure of individual, conditioned hereditary risk factors which will allow to prognose the inclination to emergence of bronchical diseases between workes in unhealthy trades in propertime, and to foressee the clinical flow of the disease, complications peculiarities between patients and to correct therapy. Key words: Bronchitis, Dust Professions, HLA-antigens, 1-proteinasa ingibitor, dermatoglyfic.

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