3

IIIINOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao

?i. I.?. Ie?iaiaa

OAeE: 618.5-089.888.61-002.3-085.849.19/615.9.034.8]-084

IE*EE AIAe??E C?IIA?EIAE*

?IEUe AeAOIENEEAOe?? OA EACA?IOA?AI?? A EIIIEAENI?E I?IO?EAEOEOe?
AI?EII-CAIAEUeIEO ONEEAAeIAIUe EANA?NUeEIAI ?ICOEIO O II?IAe?EUe A?OIE
?ECEEO

14.01.01 — aeooa?noai ? a?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

A?iieoey – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai??

?i. ?.ss. Ai?aa/aanueeiai IIC Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? Oi?eue Noaoai
Aieiaeeie?iae/, Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.ss.
Ai?aa/aanueeiai IIC Oe?a?ie, caa?aeoaa/ eaoaae?e aeooa?noaa oa
a?iaeieia?? iaaee/iiai oaeoeueoaoo.

Io?oe?ei? iiiiaioe:

— aeieoi? iaaee/ieo iaoe, i?ioani? Iaci?/oe Ai?en Oaaei?iae/,
A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.?. Ie?iaiaa IIC
Oe?a?ie, caa?aeoaa/ eaoaae?e aeooa?noaa oa a?iaeieia?? ?1;

— aeieoi? iaaee/ieo iaoe, i?ioani? Ia?e?i Eaii?ae Ai?eniae/,
Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai
IIC Oe?a?ie, caa?aeoaa/ eaoaae?e aeooa?noaa oa a?iaeieia??.

I?ia?aeia onoaiiaa: ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII
Oe?a?ie, a?aeae?eaiiy iaoieia?? aaa?oieo oa iieia?a, i. Ee?a.

Caoeno a?aeaoaeaoueny “_30” eenoiiaaea 1999 ?ieo i 12 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 05.600.01 i?e A?iieoeueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i. I.?. Ie?iaiaa IIC Oe?a?ie ca
aae?anith: 21000, Oe?a?ia, i. A?iieoey, aoe. Ie?iaiaa, 56.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?. Ie?iaiaa (21000, Oe?a?ia,
i. A?iieoey, aoe. Ie?iaiaa, 56).

Aaoi?aoa?ao ?ic?neaiee “19” aeiaoiy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee E 05.600.01
Iieeaeueei I.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Anooi. Ca aeaieie ca?oa?aeii? noaoenoeee /anoioa iia?aoe??
eana?nueeiai ?icoeio (IE?) c?inea a on?o e?a?iao na?oo. O NOA oa Eaiaae?
ca inoaii? ?iee a?aenioie aeiaaee?a aaaeii?iaeueiiai ?iaei?ic??oaiiy
ca?eueoeany a i’youe ?ac?a (c 5 aei 25 %), a, neaaeiii, a A?aceei? oa
Eoa? eiaei? o?ao? iieiae cae?i/othoueny IE? (Cox S., Gilstrap ?., 1989;
Peterson C., Medchill M., Cordon D., 1996; Evaldson G.R., 1995). O
e?a?iao Cao?aeii? ?a?iie oeae iieaciee noaiiaeoue 16-18 %, a Oe?a?i?
ca aeaieie noaoenoe/ieo ca?o?a I?i?noa?noaa ioi?iie caei?ia’y — 8 %
(Aaioeeianeee A., 1998; Cieuenueeee N.ss., A?oaiiiia A.N., 1998).
Iaeiae, iaeii/anii ci caieueoaiiyi /anoioe IE? caaino?eeeny ieoaiiy,
iia’ycai? c iiaeaeuaiiyi aaciaee aeey ii?iaeieue (Oainoee I.I., Iaci?/oe
A.O., AEo/aiei I.A., 1998). Ianaiia?aae aeeeeeathoue na?eicia
caiaiiei?iiy ai?eii-caiaeuei? oneeaaeiaiiy (ACO) iineyiia?aoeieiiai
ia?iiaeo. Ca ?nioth/eie aeaieie a?ae 6-11 % aei 25-30 % iia?aoeaieo
iieia?a noi?iaiaeaeothoueny ACO, a o a?oii iaoei?ioie c aenieei
iioaeoeieiei ?eceeii oeae iieaciee iiaea aeinyaiooe 60 — 80 % (Ea?eiia
A.E., Oiaeaeaaaa N.O., 1991; Hamadeh G., Dedmon C., Mozley P.D., 1995;
Hsu C.D., Witter F.R., 1995). Ca iia?aeiieaiiyi A.I. Ieeiiiaa (1991) ia
aeieth IE? i?eiaaea? 80 % an?o ?ioaeoe?eieo oneeaaeiaiue a aeooa?nuee?e
i?aeoeoe?. Aiie caeeoathoueny iaeii?th c iniiaieo i?e/ei iaoa?einueei?
nia?oiinoi oa ?iaae?aeecaoe?? iieiaeeo ae?iie (Aieaea I.A., 1998). E??i
oiai, iio??aii a?aoiaoaaoe a?aeaeaeai? ?acoeueoaoe eieae?ciaaieo oa
aaia?ae?ciaaieo oi?i ACO i?ney IE?, eio?? nooo?ai aieeaathoue ia
i?aoeacaeaoi?noue ae?iie ?ai?iaeoeoeaiiai a?eo (aeniaaeeeaee a?eue,
?iceaaee iaino?oaeueiiai oeeeeo, cieaeaiiy naenoaeueii? ooieoe??,
iie?aea?a?y, aaaaoiiaa?ioe/i? ii?ooaiiy, inoaiii?ic oiui) (Aaeiae/aiei
TH.I. ? ni?aaao., 1996).

Iniaeeai? aino?ioe i?iaeaia ACO ioa?ia??th iaaoaa? oaia?, eiee iioiia
?aaeoeai?noue ii?iaeieue cieaeaia, a oe?iea e, ia?iaeei, ia?aoeiiiaeueia
aeei?enoaiy aioeaiioeeia i?ecaiaeeoue aei aeieeiaiiy ?acenoaioieo
ainiioaeueieo ooaiia iie?ii?aaiiciia i ii?ooaiiy ii?iaeueiiai aiioeaiico
a aeiiie o iiney?iaeiaiio ia?iiaei. E??i oiai iio??aii caoaaaeeoe, ui
c?inea /anoea iaoe??ioie, ye? o?aaeeoe?eii iaeaaeaoue aei a?oie ?eceeo
uiaei aeieeiaiiy ACO (Litta P., 1995; Ia?e?i E.A., Ie?iaiaa A.?.,
Oea/aiei N.E., 1996; Aiaeeaanueea I.A., Eai?inueeee A.A., AEoe N.?.,
1998; I?ioeaiei I.I., Iaci?/oe A.O., 1999).

Ioaea, aeniea /anoioa ACO eana?nueeiai ?icoeio, aaeeeee a?aenioie ?o
eaoaeueieo aene?ae?a, iaaeinoaoiy aoaeoeai?noue a?eueoino?
cai?iiiiiaaieo i?io?eaeoe/ieo caoiae?a coiiaeththoue iino?eio
caoe?eaaeai?noue iaoeiaoe?a oe??th i?iaeaiith. Caaaeath/e ia ?? aaeeeo
iaaee/io oa nioe?aeueio cia/ou?noue, aiia iaaoaa? aea?aeaaii? aaae.

Aeooaeuei?noue i?iaeaie. Na?aae iniiaieo iai?yie?a i?io?eaeoeee
?ioaeoe?eieo oneeaaeiaiue eana?nueeiai ?icoeio ?ioiio?iiia oa?ai?y
iaa?oioiaaii caeia? iaeia c iaeaaaeeea?oeo i?noeue. ?? e?ioeaaith
iaoith ? iiaeoethaaiiy aaeaeaaoieo ?ioiieo ?aaeoe?e o a?aeiia?aeue ia
?ioaeoe?eio aa?an?th. Iaeiae ia??aeei i/?eoaai? ?acoeueoaoe ??ciyoueny c
?aaeueieie. I/aaeaeii i?e/eiith oeueiai ? ?yae iaeaea iaae??oaieo
ieoaiue.

Ianaiia?aae, ia anoaiiaeai? e?ioeaa? ia’?eoeai? e?eoa??? ?ioiiao?o/aiiy.
Iaia? ?aeiino? oao?aoe?a o iiaeyaeao ia iaoiaeieia?/i? i?aeoiaee aei
aeai?o ?ioiio?iiiiai na?aaeieea. E??i oiai, a i?aeoe/i?e iaaeeoeei?
?niothoue o?oaeiiu? c i?iaaaeaiiyi ?ioiiiai eiio?ieth aoaeoeaiino?
oa?ai??.

A?aeoae, oea na?ae/eoue i?i aeooaeuei?noue ?ic?iaee aeueoa?iaoeaiiai
iai?yieo ?ioiiiai ao?o/aiiy — aeno?a?ioiii? oa?ai??. Aiia, c iaeiiai
aieo, ia?aaeaa/a? canoinoaaiiy eiiieaeno caoiae?a, ni?yiiaaieo ia
onoiaiiy i?e/ei ?ioiiaeao?oeeoo oeyoii ei?aeoe?? i?e?iioi/aiiy
?ioiieiiiaoaioieo ee?oei, c ?ioiai — ei?aeoe?th ?io?aoeaethey?iiai
aiiainoaco. O oeueiio eiioaeno? iaea?eueo ia?niaeoeaiei aa/eoueny
iaeo?ae?caoe?y aiaeiaaiii? ?ioieneeaoe?? (A?) ye aeiaie? aaaiiiai
?ioiiaeai?aneaiiai /eiieea.

Ae??oaiiy oeueiai caaaeaiiy iia’ycothoue ?c canoinoaaiiyi
?io?aei?ii?aeueii? aeaoieneeaoe?? oa aia?a?? iioe/iiai aei?ii?ithaaiiy.
Inoaiiy aaea caeiaoea nai? aeciaiiy ? ana oe?oa aeei?enoiao?oueny o
i?aeoe/i?e iaaeeoeei? (Oieeue N.A., O?ai/oe A.TH., Ieoaeeaiei A. O. e
ae?., 1993, Oi?eue N.A., 1994, Ia?e?i E.A., Oaoiaa I.A., Eoieiaoeue
I.A., 1998). Iiaeeeaino? ?io?aei?ii?aeueii? aeaoieneeaoe?? ii?aoeueiaai?
a ee?i?oe? iiaa?oiaai. Oea coiiaeaii oei, ui ua ia aeinoaoiuei aea/aia
oa?iaeieia?y aioa?ini?aaio?a (AN), ye ? ia ?ic?iaeaia a iiai?e i???
e?eoaaeueia oaeoeea iaeo?ae?caoe?? aiaeioieneeico. Ia?oi/a?aia?e
iaoeia?e ?ic?iaoe? iiaeii? i?aeeyaaoe ieoaiiy aieeao aioa?ini?aaio?a ia
?ioiiee aiiainoac, aca?iiae?y ?o c ?ioeie ?ioiio?iiieie na?aaeieeaie,
iiaeeeaino? iioaioe?thaaiiy ?o ae??.

O i?aeoe/i?e iaaeeoeei? a?aenooi?e /?oeee eaai?aoi?iee eiio?ieue
aoaeoeaiino? aeaoieneeaoe??. Oea i?ecaiaeeoue aai aei iaaeinoaoiueiai
“i/euaiiy” i?aai?cio, ui ?iaeoue iaaoaeoeaieie aaeeaai? caoiaee, aai ae,
iaaiaee, iaaei??ia aoa?aioia oa?ai?y noi?iaiaeaeo?oueny ii?ooaiiyi
?iiiiai aaeaino oa ?ioeie ?iceaaeaie aiiainoaco. Ia’?eoeai? e?eoa???
aea?aaeaioiino? aeaoieneeaoe?eii? oa?ai?? o ii?iae?eue a?oie ?eceeo, ui
ia?aianee IE?, aeioaia? ia anoaiiaeai? ?, a?aeiia?aeii, ia
aeei?enoiaothoueny. Caeeoathoueny iaeaea ia aea/aieie ?ioiiiiaeoethth/?
aniaeoe ae?? aeaoieneeaoe?eieo caoiae?a o ii?iae?eue, ui ia?aianee IE?.

Aioa?ini?aoe?y oa eaca?ioa?ai?y iathoue ??ci? oeyoe ?aae?caoe??
?ioiiiiaeoethth/iai aieeao, ui oaae aeicaiey? i?iaiicoaaoe iineeaiiy
?ioiio?iiii? ae?? i?e ?o ii?aeiaiiio canoinoaaii?. I?ioa ?noeii?noue
oeueiai i?eiouaiiy o ii?iae?eue a?oie ?eceeo, eio?? ia?aianee IE? a
ee?i?/ieo oiiaao ua ia aea/aeany.

Ia iniia? oeueiai, anoaiiaeaii iio?aao eiiieaeniiai aea/aiiy ci?i
?ioiiiai noaoono ii?iae?eue caeaaeii a?ae aeeaeie A? aeey
aeaoaeuei?oiai iaa?oiooaaiiy iiaiai i?aeoiaeo aei i?io?eaeoeee ACO
eana?nueeiai ?icoeio ?c canoinoaaiiyi aioa?ini?aoe?? oa eaca?ioa?ai??.

A?aoiaoth/e aeooaeueiinoue i?iaeaie, ?? i?aeoe/io, iaoeiao i nioeiaeueio
aaaii?noue, o oe?e ?iaioi iinoaaeaia iaoa: i?aeaeueoe aoaeoeai?noue
iaoiaaiaoe/ieo i?ia?ai caiia?aaiiy ai?eii-caiaeueieo oneeaaeiaiue
eana?nueeiai ?icoeio o ii?iae?eue a?oie ?eceeo oeyoii ei?aeoe?? ?ioiii?
?acenoaioiino? no/anieie iaoiaeaie oa?ai?? — aioa?ini?aoe??th oa
eaca?iei ii?ii?iaiiyi.

O ca’yceo c oeei aoee iinoaaeaii oaei caaaeaiiy:

1. O ii?iaeieue a?oie ?eceeo, ye? ia?aianee IE?, aeine?aeeoe ciiie
iioiiiai noaoono, a?iioaoe/ii iia’ycai? c aiaeiaaiiith ?ioieneeaoe??th.

2. Aea/eoe ee?i?/io, ?ioiieia?/io oa aeaoieneeaoe?eio aoaeoeai?noue
canoinoaaiiy aioa?ini?aoe?? a eiiieaeniie i?ioieaeoeoei ACO
eana?nueeiai ?icoeio o ii?iaeieue a?oie ?eceeo.

3. Aeyaeoe aieea eaca?ioa?ai?? ia iieacieee ?ioi?oaoo oa aiaeiaaiii?
?ioieneeaoe?? o ii?iae?eue a?oie ?eceeo.

4. Aea/eoe aeioeieueiinoue eiiaiiiaaiiai canoinoaaiiy aioa?ini?aoe?? oa
eaca?ioa?aii? c iaoith caiia?aaiiy ACO o ii?iaeieue a?oie ?eceeo.

5. ?ic?iaeoe i?aeoe/i? ?aeiiaiaeaoe?? aeey aaeineiiaeaiiy iaoiae?a
ianoaaeaiiy ii?iae?eue oa i?io?eaeoeee ACO eana?nueeiai ?icoeio.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
aeine?aeaeaiiy ? o?aaiaioii ieaiiai? iaoeiai? ?iaioe eaoaae?e aeooa?noaa
oa a?iaeieia?? Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai?? ?i.
?.ss. Ai?aa/aanueeiai “Canoinoaaiiy aioa?ini?aaio?a, ?ioiiiiaeoeyoi??a
oa aaiaoii?ioaeoi??a o aeooa?noa?, a?iaeieia?? oa aiaeie?eii?e
o??o?a??”.

Iaoeiaa iiaecia ?iaioe. O aeena?oaoei? ?aae?ciaaiee ia i?aeoeoe? iiaee
iaoiaeieiai/iee iiaeo?ae aei i?iaeaie iiaeaeuaiiy aoaeoeaiinoi
i?ioieaeoeee ACO eana?nueeiai ?icoeio o ii?iaeieue a?oie ?eceeo, yeee
aaco?oueny ia eiia?iiaaiiio canoinoaaii? ?ioiio?iiieo cania?a ??cii?
ni?yiiaaiino?.

Aia?oa:

— ia iiaenoaai aiaeico eioa?aoo?ieo iiaiaeiieaiue oa aeaniiai aeinaiaeo
(o ni?aaaoi?noa?) nenoaiaoeciaaii iiai iaoiaee aeiaaiinoeee AI, yei
aeeeaaeaii a iaoiaee/ieo ?aeiiaiaeaoeiyo “Iaoiaee aeine?aeaeaiiy
aiaeiaaiii? ?ioieneeaoe?? i?aai?cio”;

— o ii?iaeieue, ui ia?aianee IE?, o aeeiaiioei i?ney?iaeiaiai ia??iaeo
i?iaaaeaii eiiieaenia aeineiaeaeaiiy iieacieeia AI. Oea aeaei ciiao
aeyaeoe o iaoe??ioie c oaeoi?aie ?eceeo iaaeinoaoith ni?iiiaeiinoue
aeaoieneeaoe?eieo nenoai i?aaiicio;

— o i?iiia?iaaieo ii?iaeieue c a?oie ?eceeo aea/aii caeaaei?noue
iioiii? aiaeiiaiaei i?aaiicio aiae aeeaeie aiaeiaaiii? ?ioieneeaoe??;

— cai?iiiiiaaii i?iaiicoaaoe ACO eana?nueeiai ?icoeio ca iieacieeaie
aiaeiaaiii? ?ioieneeaoe?? a iaeaeeae/iio i?neyiia?aoeieiiio ia?iiaei;

— aeey ii?iae?eue c a?oie ?eceeo canoiniaaii iiaeai? aioa?ini?aaioia in
vitro;

— ?ic?iaeaiee i iaoiaaiaoe/ii iaa?oioiaaiee eiiieaenieie
aeineiaeaeaiiyie aiaeiaaiii? ?ioieneeaoe?? oa iioiiiai noaoono
aoaeoeaiee iaoiae i?ioieaeoeee ACO eana?nueeiai ?icoeio o ii?iaeieue c
a?oie ?eceeo, a yeiio ii?yae ?c o?aaeeoe?eiith oa?aii?th canoiniaaii
aioa?ini?aoeith o ii?aeiaiii c eaca?iei ii?ii?iaiiyi ia?aaeiuei?
/a?aaii? no?iee. O ni?aaaoi?noa? c Oi?eai N.A. caiaoaioiaaii aeiao?ae
“Niin?a i?io?eaeoeee ai?eii-caiaeueieo oneeaaeiaiue eana?nueeiai
?icoeio” (cayaea ? 99042451 a?ae 29.04.1999 ?., iiceoeaia ??oaiiy a?ae
11.06.1999 ?.);

— anoaiiaeaii, ui aeinoaoiy aeaoieneeaoeieia oa?aiiy aioa?ini?aaioii
“Ea?aia?o” iioaioeith? ?ioiiiiaeoethth/o aeith eaca?a o ii?iaeieue c
oaeoi?aie ?eceeo aeieeiaiiy ACO eana?nueeiai ?icoeio.

?yae noi?ioeueiaaieo o ?iaio? eiioeaioe?e iiaea ?icoe?ithaaoeny ye
oai?aoe/ia iniiaa aeey iiaoaeiae aeeoa?aioe?eiaaieo i?ia?ai i?io?eaeoeee
oa e?eoaaiiy ACO eana?nueeiai ?icoeio. Iien iaoieia?/ieo yaeu o
aeeiai?oe? ioa?ia??th iaa?oioiao? aeioe?euei?noue iiaeaeueoi? iaoeiai?
?ic?iaee iaaeeeaiaioicii? ei?aeoe?? ii?ooaiue aiiainoaco o ii?iae?eue
a?oie ?eceeo.

I?aeoe/ia cia/aiiy ?iaioe aecia/a?oueny ?ic?iaeith oaeineiiaeaii?
i?ia?aie ae?aaiinoeee ACO eana?nueeiai ?icoeio, eeth/iaei iiiaioii yei?
? ioe?iea A? ye ?ioiioiene/iiai /eiieea.

I?inoioa e ?ioi?iaoeai?noue cai?iiiiiaaii? ae?aaiinoe/ii? i?ia?aie
?iaeyoue ?? i?eaeaoiith aeey canoinoaaiiy ia on?o ??aiyo iaaee/ii?
aeiiiiiae (iiia?ia ?aeiiia e?ea?iy, oeaio?aeueia ?aeiiia e?ea?iy,
niaoe?ae?ciaaiee noaoe?iia?).

Aeaeaii ocaiaeaeai? c IIC Oe?a?ie iaoiaee/i? ?aeiiaiaeaoe?? “Iaoiaee
aeine?aeaeaiiy aiaeiaaiii? ?ioieneeaoe?? i?aai?cio”, ye? ?ic?neai? ia
aae?ane oi?aae?iue ioi?iie caei?ia’y iaeaea?aeaaei?i?no?aoe?e oa
iaeanieo iaaee/ieo a?ae?ioae an?o iaeanoae Oe?a?ie, aeueo iaaee/ieo
iaa/aeueieo caeeaae?a, i?io?eueieo e?eoaaeueieo caeeaae?a oa i?ia?aeieo
oao?aoe?a.

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue anoaiiaeaii ia’?eoeai? e?eoa???
aea?aaeaioiino? aeaoieneeaoe?eii? oa?ai?? o i?neyiia?aoe?eiiio ia??iae?
c iaoith i?io?eaeoeee ACO o ii?iae?eue c aenieei ?ioaeoe?eiei ?eceeii.

?ic?iaeai? i?aeoe/i? ?aeiiaiaeaoe?? uiaei canoinoaaiiy eiiieaenii?
i?io?eaeoeee ACO eana?nueeiai ?icoeio o ii?iae?eue a?oie ?eceeo, yea
ie??i aacenii? oa?ai?? aeeth/a? aioa?ini?aoe?th oa ii?ii?iaiiy eaca?ii
ia?aaeiuei? /a?aaii? no?iee. Canoinoaaiiy oaei? i?io?eaeoe/ii? i?ia?aie
aoaeoeaii caiia?aa? ?icaeoeo ?ioaeoe?eieo oneeaaeiaiue ioa?ia??th o
oe??? eaoaai??? iaoe??ioie.

?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeaii a
e?eoaaeueii-ae?aaiinoe/iee i?ioean aeooa?nueeeo noaoe?iia??a
I?aeaiei/enueei? oeaio?aeueii? ?aeiiii? e?ea?i? (Oa?iii?euenueea
iaeanoue), i?nueeiai iieiaiaiai aoaeeieo (i. ?aaii-O?aie?anuee),
iaeaniiai ee?i?/iiai iieiaiaiai aoaeeieo (i.
Oiaeueieoeueeee).

Iniaenoee aianie caeiaoaa/a. On? aoaie aeine?aeaeaiiy aaoi? cae?eniea
naiino?eii, aeeth/ath/e ieaioaaiiy, iae?e, noaoenoe/io ia?iaeo oeeo?iaeo
aeaieo, aiae?c io?eiaieo ?acoeueoao?a i?iaaaeaieo ee?i?/ieo
niinoa?aaeaiue, ?ic?iaeo iniiaieo iieiaeaiue oa aeniiae?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue, ye?
aeeth/ai? aei aeena?oaoe??, ii?eethaeiaii ia I?aeia?iaei?e eiioa?aioe??
“Aeooaeuei? ieoaiiy ii?oieia??” (Oa?iii?eue, 1996), ? I?aeia?iaeiiio
eiia?an? nooaeaio?a oa iieiaeeo a/aieo (Oa?iii?eue, 1997), can?aeaii?
iaeanii? anioe?aoe?? aeooa??a-a?iaeieia?a Oa?iii?euenueei? iaeano?
(1998), ni?eueiiio can?aeaii? eaoaae? aeooa?noaa oa a?iaeieia??
iaaee/iiai oaeoeueoaoo oa oaeoeueoaoo i?neyaeeieiiii? ina?oe,
oaeoeueoaonueei? o??o?a??, oaeoeueoaonueei? oa?ai??, oieoaeueii? oa?ai??
?1, oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe, iaae?ao??? oaeoeueoaoo
i?neyaeeieiiii? ina?oe, ii?iaeueii? o?c?ieia?? Oa?iii?euenueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss. Ai?aa/aanueeiai (Oa?iii?eue,
1999).

Ioae?eaoe??. Iniiai? ?acoeueoaoe ?iaioe iioae?eiaai? a iaoeiaeo
aeo?iaeao — 5 noaoae, o iaoa??aeao iaoeiaeo eiioa?aioe?e – 5, o
iaoiaee/ieo ?aeiiaiaeaoe?yo “Iaoiaee aeine?aeaeaiiy aiaeiaaiii?
?ioieneeaoe?? i?aai?cio”.

No?oeoo?a ? ianya ?iaioe. Aeena?oaoe?y neeaaea?oueny c anooio, 6
?icae?e?a, aeniiae?a oa nieneo aeei?enoaii? e?oa?aoo?e, yeee aeeth/a?
222 aeaea?aea. Aeeeaaeaia ia 178 noi??ieao eiii’thoa?iiai oaenoo, ?c ieo
146 noi??iie caeiathoue oaenoia? iia?aeiieaiiy, 7 — ?ethno?aoe??, 25 —
nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae.

INIIAIEE CI?NO ?IAIOE

?icae?e ia?oee — “Ei?aeoe?y ?iceaae?a ?ioi?oaoo ? aioeoiene/ii?
?acenoaioiino? i?aai?cio a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? i?ney
eana?nueeiai ?icoeio” — i?enay/aiee oai?aoe/iiio aiae?co e?oa?aoo?ieo
iia?aeiieaiue c oaie aeena?oaoe??.

Anoaiiaeaii, ui i?ney?iaeiaee ia??iae noi?iaiaeaeo?oueny ?icaeoeii
o?aiceoi?iiai ?ioiiaeao?oeeoiiai noaio. Ia oe? iia?aoeaiiai ao?o/aiiy
?iceaaee ?ioiiiai aiiainoaco iiaeeaeththoueny ? iio?aaothoue
iaaeeeaiaioicii? ei?aeoe??.

?iceaaee iaoaaie?cio, i?eoaiaii? iinoiia?aoe?eiiio ia??iaeo, ye i?aaeei,
ni?e/eiythoue ?icaeoie aiaeiaaiii? ?ioieneeaoe??. A?eueo?noue aaoi??a
noeeythoueny aei aeoiee, ui aaeioieneie ? iiooaeiei ?ioiinoi?aneaiei
oaeoi?ii. Aea/aiiy nooiaiy caeaaeiino? ii?ooaiue ?ioi?oaoo a?ae aeeaeie
A? iiaea noai?eoe iniiao aeey ?ic?iaee oaeoeee ea?iaaiiai i?aeaeuaiiy
?ioiii? ?acenoaioiino? oeyoii iiaeoeyoe?? oaeoi??a aeaoieneeaoe?? oa
aioeoiene/iiai caoenoo ee?oei.

Niaoe?aeuei? aeine?aeaeaiiy i?iaeaie onoiaiiy iinoiia?aoe?eii?
?ioiinoi?an?? aeicaieeee aeie?aieoe o i?e ia?niaeoeai? eiiiiiaioe
oa?ai??: aioa?ini?aoe?th oa eaca?ia aei?ii?ithaaiiy. Aioa?ini?aaioe
ae?i?iothoue niieoee c ?ioiinoi?aneaiei aieeaii. Eaca?ia aei?ii?ithaaiiy
ni?ey? ei?aeoe?? ?io?aoeaethey?iiai aiiainoaco. Ii?aeiaia canoinoaaiiy
aioa?ini?aoe?? oa eaca?ioa?ai?? aeicaiey? i?iaiicoaaoe iineeaiiy
?ioiio?iiiiai aieeao. I?ioa, ?aaeuei?noue oeueiai i?eiouaiiy a oiiaao
ee?i?ee noiniaii ii?iae?eue c oaeoi?aie ?eceeo, ui ia?aianee IE? ia
aea/aeany.

I?iaaaeaiee aiae?c e?oa?aoo?e, aeyaea iio?aao eiiieaeniiai aea/aiiy ci?i
?ioiiiai noaoono ii?iae?eue caeaaeii a?ae aeeaeie aiaeiaaiii?
?ioieneeaoe?? aeey iaoiaaiaoe/iiai iaa?oiooaaiiy iiaiai i?aeoiaeo aei
i?io?eaeoeee ACO eana?nueeiai ?icoeio ?c canoinoaaiiyi aioa?ini?aoe?? oa
eaca?ioa?ai??.

?icae?e ae?oaee — “Iaoa??aee ? iaoiaee i?iaaaeaieo aeine?aeaeaiue” —
i?enay/aiee iieno iaoiae?a oa i?aai?caoe?? aeena?oaoe?eiiai
aeine?aeaeaiiy.

E??i caaaeueiii?eeiyoeo, ianoaaeaiiy ioiieei niaoe?aeuei? iaoiaee
aeine?aeaeaiiy A? oa ?ioiiiai noaoono. Aeey aecia/aiiy ??aiy A?
aeei?enoaee ae?aaiinoe/i? oanoia? ?aaeoe??, ni?yiiaai? ia aeyaeaiiy ye
?iaiy aiaeioienaii? (nia?iaoici?aeiee oano (NO) (A?aoiye A.A., Aao
I.Ae., ?iiaithe A.I., 1993), eiioeaio?aoe?y na?aaeiuei-iieaeoey?ieo
iaioeae?a (NII) (Aaa?eyeyi I.E., Eeiaoiaa A.E., 1984), eiao?oe?aio E —
ni?aa?aeiioaiiy o?aeoe?e (Ai?aeaaaa E.I., Eaaiiaa I.I., Nieiaueaaa A.E.
e ae?., 1986), oae ? aiaeioieneeico (noia?ia oiene/i?noue e?ia? oa
?ioa?noeoe?eii? ??aeeie (NOE) (Aao I.Ae., 1992), aioeoiene/ia
?acenoaioi?noue ee?oei e?ia? (A?EE) (Aao I.Ae., Aeai’yiaiei A.A.,
Aanenothe ?.?., 1993), eaeeioeeoa?iee ?iaeaen ?ioieneeaoe?? (E??)
(Eaeueo-Eaeeo ss.ss., 1947), aaiaoieia?/iee iieaciee ?ioieneeaoe?? (AI?)
(Aaneeueaa A.N., Eiia? A.E., 1983).

?ioiiee noaoon ioe?ithaaee ca aeayeeie iieacieeaie ee?oeiii? oa
aoii?aeueii? eaiie. C iaoith iiaeeeaoei? O- i A-eiioioeeoia
canoiniaoaaee iaoiae eiiaiiiaaiiai ?icaoeiooai?aiiy ca Mendes N.F. ?
ni?aaao. (1974). Noaiiioeyoeith aeoeaieo O-eiioioeeoia (Aaeo-?OE)
iiae?aoiaoaaee ca aeiiiiiaith iaoiaeo Smith ? ni?aaao. (1975).
Aecia/aiiy eieueeinoi oaioieiii?acenoaioieo i oaioieiii/ooeeaeo A-?OE
o ia?eoa?e/iie e?iai i?iaiaeeeiny ca iaoiaeii Limatibul S. et al.
(1978). Ae?aoiaoaaee oaioieiiiaee eiaoioei?io (niiaaiaeiioaiiy
oaioieii?acenoaioieo i oaioieii/ooeeaeo A-?OE). Eiaoioei?io
iioiinoeioethth/i? aei? oa eiao?oe??io ?ioiiiiaeoeyoe?? oa?ai??
ae?aoiaoaaee ca iaoiaeii Aiae?ae/eia I.A., ?uoe ?.N., Ainiiaea?nueeiai
?.ss. (1995). Eiioeaio?aoeith ne?iaaoeiaeo iioiiaeiaoeiiia eeania A, I
i G aecia/aee aiioiii/iei iaoiaeii ca Badin A., Ronsellet S. o
iiaeeoieaoei? Ea?nueeiai A.A. i E?aa/aiei I.I. (1971). ??aaiue
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) aeine?aeaeoaaee iaoiaeii
i?aoeei?oaoe?? a 10 % ?ic/ei? iie?aoeeaiae?eieth c iieaeoey?iith ianith
6 EAe (Ianyii?eiaa I.A., 1994).

Ianoaaeaiiy i?iaiaeeee ia 2, 5-6, 9-11 aeiae i?neyiia?aoe?eiiai
ia??iaeo.

Io?eiai? aeai? ii??aithaaee c ia?aiao?aie 32 ii?iae?eue,
i?neyiia?aoe?eiee ia??iae yeeo ia?aa?aaa aac oneeaaeiaiue.

?acoeueoaoe aeine?aeaeaiiy ia?iaeaii iaoiaeii aa?iaoeieii? noaoenoeee
oeyoii ia/eneaiiy na?aaeiuei? a?eoiaoe/ii? (I) i ?? na?aaeiuei? iioeaee
(m) c o?aooaaiiyi /enea niinoa?aaeaiue. Ioeiiea aeinoiai?iinoi
cae?enithaaeany ca aeiiiiiaith e?eoa?iy Nouethaeaioa ca
iieacieeii ?. ??aaiue iaoi/iino? oa ??aaiue eiia??iino? iathoue
a?a?o?a?iee oa?aeoa?, oiio ie aecia/eee aeia??/? iaae? aeey ??aiy
iaoi/iino? 5 %, aeey ??aiy eiia??iino? ia iaioa 95 %.

C iaoith aeyaeaiiy iiaeeeai? caeaaeiinoi iiae io?eiaieie
iieacieeaie aecia/aee eiaoioei?io ei?aeyoei? (r). Noaoenoe/ia ia?iaea
oeeo?iaiai iaoa?iaeo aeeiioaaeany ca aeiiiiiaith i?eeeaaeieo i?ia?ai
iaoaiaoe/ieo aeaeo?iiieo oaaeeoeue c aeei?enoaiiyi eiii’thoa?a.

A o?aoueiio ?icae?e? iiaeaii ee?i?/io oa?aeoa?enoeeo ianoaaeaieo
ii?iae?eue. Oi?ioaaiiy eiioeiaaioo ianoaaeaieo i?iaaaeaii iaoiaeii
naeaeoeaiiai iaai?o ii?iaeieue, ?ic?iaeaeaieo eana?nueeei ?icoeiii, ye?
iaee caaaeueiiaeciai? oaeoi?e ?eceeo aeieeiaiiy ioa?ia?aeueii?
?ioaeoe??: 1. I?ci?e aanoic. 2. Aiai?y aaa?oieo. 3. O?aaioiee oa?aeoa?
iia?aoeaiiai ao?o/aiiy. 4. O?eaaeee aacaiaeiee ia??iae. 5. Iayai?noue
aaeoa??aeueieo aiaieu ?ioaeoe??. 6. Caoyaei? iieiae, ye? ia?aaeoaaee
iia?aoe??. 7. III-IV nooi?iue /enoioe i?oae iaia?aaeiaei? iieia?a. 8.
Cia/ia e?euee?noue aaa?iaeueieo aeine?aeaeaiue o iieiaao. 9.
Iaaeinoaoiuei a?aeiiaeaia iia?aoe?eia e?iaiao?aoa. 10. O?eaae?noue
iia?aoe?? a?eueoa 1 aiaeeie. 11. O?eaaea aei?iaeiaa aini?oae?caoe?y.
12. Caa?ica ia?a?eaaiiy aeaii? aaa?oiino?. 13. O??o?a?/ia e?eoaaiiy
?noi?ei-oea?a?eaeueii? iaaeinoaoiino?. 14. *ano? aai?oe (ieiia?euei?,
ooo/i?). 15. Iaee??iiy. 16. Aeno?aaai?oaeuei? caoai?thaaiiy (?aaiaoeci,
oeoe?iaee ae?aaao). 17. A?e aaa?oieo iaioa 20 ?ie?a.

I?iaiinoe/ii aenieee nooi?iue ?eceeo aeieeiaiiy ioa?ia?aeueii? ?ioaeoe??
aoa e?eoa???i a?aeai?o aeey ?o ee?i?ei-eaai?aoi?iiai ianoaaeaiiy.

I?aenoioaaaoe iniiai? nea?ae oa ia’?eoeai? aeai?, aeyaeai? a
iaeaeeae/iio i?neyiia?aoe?eiiio ia??iae? o ii?iae?eue a?oie ?eceeo
aeieeiaiiy ACO eana?nueeiai ?icoeio, aeae?eeee o?e iniiai? ee?i?/i?
neiae?iie:

— neiae?ii ooieoe?iiaeueii? eeoeiai? iaaeinoaoiino?, ui i?iyaeyany
ao?aoith aiaoeoo, ioaeioith, noo?noth oa a??eioith a ?io?, i?eai?/aiiyi
ia?enoaeueoeee, acaeoooyi aeeaioa;

— neiae?ii aiaeiaaiii? ?ioieneeaoe??, ui i?iyaeyany:

a) ooieoe?iiaeueieie ?iceaaeaie ia?aiai? ?aaoeyoe?? (a?eue aieiae,
niieea?noue, caaaeueia neaa?noue, caiaii?i/aiiy);

a) ?iceaaeaie oeaio?aeueiiai e?iaiia?ao, i?e?ioee?eoeyoe?? oa oeaieiiiai
iaoaaie?cio (ae?ioe?aiic, ae?ae?noue, ia?io?ia?noue oe??ieo iie?ea?a,
cieaeaiiy oo?ai?o oe??e, oeaiei i?aeoe??ii? iniiae, oao?ea?ae?y,
a?oa??aeueia a?ia?oaic?y, aneiao??y a?oa??aeueiiai oeneo, eieae?ciaai?
iaa?yee);

a) ii?ooaiiyi oa?ii?aaoeyoe?? (a?ia?oa?i?y);

a) aaiaoieia?/ieie c?ooaiiyie;

— aieueiaee neiae?ii, yeee i?iyaeyany aieai ii oiaeo i?neyiia?aoe?eii?
?aie, aieth/?noth i?e iaeueiaoe?? oe??? ae?eyiee.

On?o 122 ae?iie iiae?eeee ia /ioe?e a?oie ca iaoiaeii ?aiaeii?caoe??.
I?aaenoaaieee eiaeii? c a?oi io?eioaaee aacenio oa?ai?th, /e ia ?? oe?
canoiniaoaaee ia?i?aeueiee i?eeii ni?aaioo, eaca?ia ii?ii?iaiiy
i?neyiia?aoe?eii? ?aie aai ?o ii?aeiaiiy.

I?eaaaeai? ?acoeueoaoe ee?i?/iiai aiae?co e?ia?, na/? oa i?ioa?iai?? a
iaoe??ioie an? /ioe?ueio a?oi na?ae/eee i?i iaaio iaeii??aei?noue ?o
neeaaeo. Oea aeicaieeei i?iaanoe eeiiiei-eaai?aoi?ia ii?iaiyiiy
aoaeoeaiinoi ?icieo iaoiaeia i?ioieaeoeee ACO eana?nueeiai ?icoeio o
oe??? eaoaai??? ae?iie.

?icae?e /aoaa?oee — “Ci?ie iieaciee?a ?ioi?oaoo oa aioeoiene/ii?
?acenoaioiino? o i?neyiia?aoe?eiiio ia??iae? eiio?ieueii? a?oie
ii?iae?eue” — i?noeoue i?ae?icae?ee: “??aaiue aiaeiaaiii? ?ioieneeaoe??
oa iieacieee ?ioi?oaoo a iaeaeeae/iio i?neyiia?aoe?eiiio ia??iae? o
ii?iae?eue a?oie ?eceeo aeieeiaiiy ACO eana?nueeiai ?icoeio”,
“Aeeiai?ea iieaciee?a aiaeiaaiii? ?ioieneeaoe?? oa ?ioi?oaoo ia 5-6
aeiao i?ney IE? o ii?iae?eue a?oie ?eceeo aeieeiaiiy ACO”, “??aaiue
aiaeiaaiii? ?ioieneeaoe?? oa ?ioiiee noaoon o ii?iae?eue a?oie ?eceeo
aeieeiaiiy ACO ia 9-11 aeiao i?ney IE?”.

Iiaeaii iiiia?aie iieaciee?a A? (oaae. 1) oa ?ioiiiai noaoono aeey
ii?iae?eue Oa?iii?euenueei? noaiiioeyoe??, i?neyiia?aoe?eiee ia??iae
yeeo ia?aa?aaa aac oneeaaeiaiue.

Ca iaoeie aeaieie o ii?iae?eue a?oie ?eceeo aeieeiaiiy ACO,
?ic?iaeaeaieo eana?nueeei ?icoeiii i?neyiia?aoe?eiee ia??iae
noi?iaiaeaeo?oueny aiaeiaaiiith ?ioieneeaoe??th. ?? iaeneiaeueia
iai?oanoaoe?y i?eiaaea? ia 2 aeiao ioa?ia??th. Ii??aiyii c ii?iaeueieie
iieacieeaie, o ii?iae?eue a?oie ?eceeo a oeae oa?i?i ioa?ia??th
oiene/i?noue e?ia?, anoaiiaeaia ca nia?iaoici?aeiei oanoii aoea iaeaea
a i?aoi?a ?ace a?eueoith, ? neeaea 9,541,59. Niaeo?ioioiiao?e/ia
aeine?aeaeaiiy ne?iaaoee e?ia? aeyaeei eiioeaio?aoe?th NII ia 254 ii —
0,4880,025 oi.iae., ia 280 ii — 0,5800,038 oi.iae., ui a?aeiia?aeii ia
33,9 % oa 36,6 % a?eueoa aiaeia?/ieo iieaciee?a o caei?iaeo ii?iae?eue
(?<0,05). Oaaeeoey 1 Aeaye? ia?aiao?e A? o ii?iae?eue c iaoneeaaeiaiei ia?aa?aii ioa?ia??th (Im) Iieacieee A?Aeiaa i?ney iia?aoe??n = 3225-69-11NO, %6,380,623,981,541,580,09NII1, oi. iae.0,4330,0220,3490,0290,3470,039NII2, oi. iae.0,3570,0150,2660,0120,2540,017E1,210,031,310,011,480,02NOE7,240,834, 691,012,620,08A?A0,7980,0160,8760,0240,9530,018A?E16,041,0715,011,0811,8 1,24E??1,120,230,940,150,920,22AI?2,060,161,540,261,240,16 O aeeiai?oe? i?ney?iaeiaiai ia??iaeo (aei 9-11 aeiae) a ii?iae?eue a?oie ?eceeo oiene/ia aa?aneai?noue ne?iaaoee e?ia?, aeyaeaia iaie ca nia?iaoici?aeiei oanoii ? eiioeaio?aoe??th NII iaeaeaio ioe?a, nooo?ai ciaiooaaeany (?<0,05). Iaeiae, o aeiaeiiio aeiaaeeo aei a?aeiia?aeieo aaee/ei caei?iaeo iaoe??ioie ia iiaa?oaeany. Cia/ia aeeni?iii?oe?y eiioeaio?aoe?? iaeaeaio o?aeoe?e NII, eiinoaioiaaia iaie a on? oa?i?ie niinoa?aaeaiiy, caa??aaea iecuee? cia/aiiy eiao?oe??ioo E: a?ae 1,180,05, ia/eneaiiai ia 2 aeiao i?ney iia?aoe??, aei 1,270,05 ia 9-11 aeiao ioa?ia??th. Iaeiei ?c oeyoia aaeaioaoei? ? aeaiiioaaiiy iaaeii?ii? eieueeinoi oieneiia a iioa?noeoeieiiio i?inoi?i. O aeiiie a?oie ?eceeo iniaeeai yne?aaei oeae oaiiiai aoa o iaeaeeae/iio iineyiia?aoeieiiio ia?iiaei. Iai?oaeaiiy aeaoieneeaoeieieo nenoai i?aaiicio noi?iaiaeaeoaaeiny ?aaeueiei ciaioaiiyi oiene/iinoi iioa?noeoeieiiai i?inoi?o aei 5-6 aeiae iiney iia?aoei? ia 52,4 % (ca NO) i?e ci?i? ia?aiao?ia oiene/iinoi ne?iaaoee e?iai ia 41,3 % (ca NO) (?<0,05). Oea aea? iiaenoaae aaaaeaoe oeae i?ino?? naiai ?iaeo ?aca?aiith nenoaiith aeaoieneeaoei? i?aaiicio, o ooieoei? yei? aoiaeeoue iiaeo?eiaiiy a oeaio?aeueiiio ?onei a?aie/ii-aeiionoeii? (ia aeeeeeath/i? aeanoaaieicaoei? iaeaaaeeeaioeo nenoai aeeoo?caaacia/aiiy) eiioeaio?aoei? oiene/ieo iaoaaieioia. Caaaeii iaoi aeaii ia caia?a/othoue i?eiouaiiyi iioaeieiaaieie iioeie iaoeiaoeyie (Naaaeueaa A.A., E?o/eineee I.A., 1989), eio?i aaaaeathoue iie?ioee?eoeyoi?ia ?onei iaei??th c ?aca?aieo eaiie aeaoieneeaoeieii? nenoaie. Ia iiiaio iaeaeueo ia?aiao??a aiaeioienai?? aioeoiene/ia ?acenoaioi?noue a?eo?ioeeo?a (A?A) noaiiaeea 0,550,04. O aeeiai?oe? i?ney?iaeiaiai ia??iaeo A?A c?inoaea, iaeiae oaeaee?noue ?aa?ano aiaeioieneeico ia a?aeiia?aeaea oae?e o caei?iaeo ii?iae?eue. Ia 9-11 aeiao ioa?ia??th o ii?iae?eue a?oie ?eceeo A?A aoea 0,760,05, ui aeinoia??ii ieae/a, i?ae o caei?iaeo ii?iae?eue (?<0,05). Iaeii/anii a i?neyiia?aoe?eiiio ia??iae? o iaoe??ioie a?oie ?eceeo aeyaeyee ?ioiio ia?aaoaeiao, ui i?iyaeyeany cieaeaiiyi /enea O- e?ioioeeo?a ? aeenaaeainii o nenoai? ?aaoeyoi?ieo ee?oei: ca?eueooaaany ai?no O- noi?ani??a, cieaeoaaany oaio?e?iiaee eiao?oe??io, ca?eueooaaeany e?euee?noue ooieoe?iiaeueii-iaiiaiioe?iieo iaeiaeeoa?aioe?eiaaieo e?ioioeeo?a, ci?ithaaany e?euee?niee neeaae ?ioiiaeiaoe?i?a, i?aeaeuoaaeany e?euee?noue Oe?E. Iaeneiaeueiee ??aaiue Oe?E aeyaeyee ia 5-6 aeiao ioa?ia??th (285,269,26). *a?ac 9-11 ae?a i?ney iia?aoe?? e?euee?noue Oe?E ciaiooaaeanue, iaeiae aei cia/aiue caei?iaeo ii?iae?eue ia iiaa?oaeany. Aeyaeaia caeaaei?noue i?ae aeayeeie iieacieeaie aiaeiaaiii? ?ioieneeaoe?? oa ?ioi?oaoo aeicaieeea o?aeooaaoe oe? ?iceaaee aiiainoaco ye iaoaaie?/io ?ioiinoi?an?th. ?ao?iniaeoeaiee aiae?c ci?i aeine?aeaeoaaieo iieaciee?a o ii?iae?eue, ye? iaee a i?neyiia?aoe?eiiio ia??iae? ?ioaeoe?ei? oneeaaeiaiiy aeyaea iiaeeea?noue i?iaiicoaaiiy ?o aeieeiaiiy ca ia?aiao?aie aiaeiaaiii? ?ioieneeaoe??. I?e ae?aaeaiiio aiaeioieneeic?, ae?aaiinoiaaiiio ca iieacieeaie aioeoiene/ii? ?acenoaioiino? ee?oei e?ia?, ia oe? iaaei??iiai iaeiie/aiiy aiaeioienei?a o ?ioa?noeoe?? ?ecee aeieeiaiiy ACO iiaeia aaaaeaoe aenieei. ?icae?e i’yoee - “Ee?i?ei-eaai?aoi?ia ii??aiyeueia ioe?iea iaoiae?a i?io?eaeoeee ACO eana?nueeiai ?icoeio o ii?iae?eue a?oie ?eceeo” - i?enay/aiee aiae?co aoaeoeaiino? cai?iiiiiaaieo caoiae?a caiia?aaiiy ?ioaeoe?eieo oneeaaeiaiue. A?i i?noeoue oae? i?aei?icae?ee: “Aoaeoeaiinoue canoinoaaiiy aioa?ini?aoe?? c iaoith i?ioieaeoeee ACO eana?nueeiai ?icoeio ca iieacieeaie aiaeiaaiii? ?ioieneeaoe?? oa iioiiiai noaoono”, “Aieea i?aaaioeaii? eaca?ioa?aii? ia ciiie aeaoieneeaoeieii? oa iioiii? nenoai i?aaiicio ii?iaeieue a?oie ?eceeo aeieeiaiiy ACO, ?ic?iaeaeaieo IE?”, “Ci?ie iieaciee?a ?ioi?oaoo oa aiaeiaaiii? ?ioieneeaoe?? o ii?iae?eue a?oie ?eceeo i?ae aieeaii ii?aeiaiiai canoinoaaiiy eaca?ioa?ai?? oa aioa?ini?aoe??”. Iayai?noue ??cieo ca neeaaeii ? aeanoeainoyie ni?aaio?a iinoaaeei ia?aae iaie caaaeaiiy aeai?o iioeiaeueiiai aeey ii?iae?eue a?oie ?eceeo. Oanooaaiiy ?n vitro aeicaieeei i?eeoe aei aeniiaeo, ui iaea?eueoo oieneica’ycoth/o aeoeai?noue noiniaii ne?iaaoee e?ia? ianoaaeoaaieo ii?iae?eue oa i?ieiiaiaai?noue ae?? ia? ni?aaio “Ea?aia?o”. Iieacaii, ui i?e?aeiaiiy aioa?ini?aoei? aei caaaeueiiaeciaieo i?ia?ai i?ioieaeoeee ACO eana?nueeiai ?icoeio o inia a?oie ?eceeo aei 9-11 aeiae iineyiia?aoeieiiai ia?iiaeo ?aaeueii ciaiooaaei aiaeioienaiith. Aeey iiaii? iaeo?aeicaoei? aiaeioieneeico oeeo caniaia aeyaeeiny iaaeinoaoiuei. Caaaeii iineeaiiy aeaoieneeaoeieii? ni?iiiaeiinoi i?aaiicio oeyoii aioa?ini?aoei? ia aieeioei ia ia?aiao?e iioiiiai noaoono. Ciiie a iioiia?aiao o ii?iaeieue, yei io?eioaaee o ioa?ia?i? iii?e caaaeueiiaaeeaaii caoiaee i?ioieaeoeee aioa?ini?aaio “Ea?aia?o” ia aiae?iciyeeny aiae oaeeo i?e aaceniie oa?aii?. Aioa?ini?aoeiy o oeeo aeiiie ia i?iyaeyea iioiinoeioethth/iai aieeao. Iaeiae, iaie a?aecia/aii iiceoeaiee aieea ia naiiii/oooy, ca?eueoaiiy e?eueeino? aeiaaee?a ia?aa?ao i?neyiia?aoe?eiiai ia??iaeo aac aa?y/ee. A o oeo aeiaaeeao, eiee oeueiai oneeaaeiaiiy ia aaeaeiny oieeiooe, na?aaeiy o?eaae?noue aa?y/ee aoea cia/ii iaioith. Caaaeii oea aeicaieeei aoaeoeai?oa caiia?aoe ?icaeoeo ACO o ioaia???, ciaioeoe e?euee?noue e?aeeiaei?a. O iaoe??ioie, eio?? io?eioaaee “Ea?aia?o” ye ie?aii, oae ? a eiia?iaoe?? c eaca?iei ii?ii?iaiiyi, ii??aiyii c oeie, yeeo e?eoaaee o?aaeeoe?eii, a?aecia/aii ciaioaiiy o?eaaeino? noa’?eoeaieo iciae ?ioieneeaoe?? (caaaeueiiai iacaeoaeaiiy, ioaeioe, caiaii?i/aiiy). E?aua i?aeaeaaaeany e?eoaaiith aiai?y, a?iii?ioa?iai?y. Anoaiiaeaii, ui eaca?ioa?aiiy o aeiiie c oaeoi?aie ?eceeo aeieeiaiiy ACO caaaeii ni?yiiaaia ia ii?iaeicaoe?th iaoaaiei/ieo ?iceaae?a i?eoaiaiieo iineyiia?aoeieiiio ia?iiaeo. I?ioa yeinoue iaeo?aeicaoei? aiaeioieneeico aiae?iciyeany aiae oaei? i?e aioa?ini?aoei?. Caieueoaiiy ?ano?niinoi eeioei e?iai iiae aieeaii eaca?ioa?aii? aiaeaoaaeiny ia?aaaaeii a inia c aeoiaeiith "cieaeaiith" ?acenoaioiinoth i iaeaea ia aieeaaei ia oi?iaiii aeaiaioe c "iecueeith" ?acenoaioiinoth. Iacaaaeath/e ia oea, a inia, ui io?eioaaee i?eaaioeaio eaca?ioa?aiith io?eiaii iioiinoeioethth/ee aoaeo (EIAe - 1,060,01, c EI - 0,72). Aiaeii/an a?aecia/aii iiceoeaiee ee?i?/iee aoaeo eaca?iiai ii?ii?iaiiy: ia?aeiieeai ciaioeeanue na?aaeiy o?eaae?noue nea?a ia caiaii?i/aiiy, nei?ioeeanue o?eaae?noue oao?ea?ae??, aa?y/ee, ciaioeeanue na?aaeiy e?euee?noue e?aeeiaei?a oa aeiaaee?a ACO (?<0,05). Oa?aeoa?ii, ui ca oiia canoinoaaiiy eaca?iiai ii?ii?iaiiy a iiiioa?ai?? /e a ii?aeiaii? c aioa?ini?aoe??th, iaie ia ca?a?no?iaaii aeiaeiiai oneeaaeiaiiy c aieo i?neyiia?aoe?eii? ?aie oa noa?iaiethoe?? iaoee. Eaca?ioa?ai?y aoea aeineoue aoaeoeaiith a eiiieaeniiio e?eoaaii? aiai?? oa a?iii?ioa?iai??. O ii?iaeieue, yei io?eioaaee eaca?ioa?aiith o ii?aeiaii c aioa?ini?aoei?th, ie??i ae?acii? aeaoieneeaoe??, aoa eieaiaeiaaiee aeaoioeeo /enaeueiinoi caaaeueii? iiioeyoei? O-eiioioeeoia. *enei O-noi?ani?ia aeinyaaei aeinoiai?ii? ii?iaeicaoei? aei 9-11 aeiae ioa?ia?ith. Oiciieiai/ia noaaieicaoeiy caaaeueii? eieueeinoi O-eiioioeeoia i niiaaiaeiioaiiy ?o aaaeo/eo noaiiioeyoeie i?e canoinoaaiii ii?aeiaii? oa?aii? noi?iaiaeaeoaaeany aiaeiiaeaiiyi ia 9-11 aeiao iiney iia?aoeaiiai ?iaei?ic?ioaiiy aaeaeaaoii? ?aaeoei? A-nenoaie iioiioaoo. Eiinoaoiaaii iiaia aiaeiiaeaiiy anio iieacieeia iioiia?aie, iaeneiaeueiee EIAe (1,080,01), EI (0,91) i aeinoaoiie ?iaaiue oaioieiiiaiai eiaoioei?ioo. Ioaea, oey noaia i?ioieaeoeee ?ioaeoe?eieo oneeaaeiaiue IE? c iioiieiai/ii? oi/ee ci?o ? iaeaieueo aei?aaaeaiith ii??aiyii c on?ia i?iaiae?ciaaieie. Cai?iiiiiaaiee niin?a aoaeoeaii caiia?aa? ACO eana?nueeiai ?icoeio ca ?aooiie iaeo?ae?caoe?? aioa?iaaiiiai eiiiiiaioo aiaeiaaiii? ?ioieneeaoe??, iineeaiiy iaoaaie?cio a oeaieiao, ciaioaiiy iaa?yeo, a?ia?ai?? ?aie, i?enei?aiiy ?iaiethoe?? iaoee oa caai?iiy ?aie ia ia?aaei?e /a?aai?e no?ioe? oa iaooe?. Oea i?eaiaeeoue aei no?eeiai aoaeoo iaeoaeaiiy, nei?i/aiiy oa?i?i?a e?eoaaiiy, ciaioaiiy e?eueeino? ACO, a i?e ?o aeieeiaii? - aei eaaoiai ia?aa?ao. O oinoiio ?icae?e? ocaaaeueiaii ?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy. C?iaeaii oae? AENIIAEE: 1. Noaiiioeyoe?y ianoaaeaieo ii?iae?eue oa?aeoa?ecoaaeany aenieei nooiaiai ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue o i?neyiia?aoe?eiiio ia??iae?. 2. I?ney?iaeiaee ia??iae o ii?iae?eue a?oie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue, eio?? ia?aianee IE? noi?iaiaeaeo?oueny aiaeiaaiiith ?ioieneeaoe??th. Ca ee?i?/ieie oa eaai?aoi?ieie aeaieie ?? iaeneiaeueia iai?oanoaoe?y i?eiaaea? ia 2 aeiao ioa?ia??th. Iciaee aiaeioieneeico caa??aathoueny aei 9-11 aeiae i?ney iia?aoe??. 3. Ca oiia aiaeiaaiii? ?ioieneeaoe?? a iaeaeeae/iio i?neyiia?aoe?eiiio ia??iae? (2 aeiaa ioaia??th) o ii?iae?eue a?oie ?eceeo, eio?? ia?aianee IE? a?aeaoaathoueny ci?ie ?ioiii? nenoaie: cieaeo?oueny /enei A-?OE, ca?eueoo?oueny e?euee?noue ooieoe?iiaeueii-iaiiaiioe?iieo iaeiaeeoa?aioe?eiaaieo e?ioioeeo?a, i?aeaeuo?oueny eiioeaio?aoe?y Oe?E. Aeyaeaia caeaaei?noue i?ae aeayeeie iieacieeaie aiaeiaaiii? ?ioieneeaoe?? oa ?ioi?oaoo aeicaiey? o?aeooaaoe oe? ?iceaaee ye iaoaaie?/io ?ioiinoi?an?th. 4. Aeiaeaoeiaa i?ecia/aiiy aioa?ini?aaioo “Ea?aia?o” i?aeaeuo? aoaeoeai?noue caaaeueiiaeciaieo i?ia?ai i?io?eaeoeee ACO o ioa?ia???, iaeiae aeinoaoiuei? iaeo?ae?caoe?? aiaeiaaiii? ?ioieneeaoe?? oa ?ioiinoeioeyoe?? i?e oeueiio ia a?aei?/aii. 5. Eaca?ia ii?ii?iaiiy oeaiei ia?aaeiuei? /a?aaii? no?iee ni?ey? ii?iae?caoe?? ee?i?/ieo ia?aiao??a ioa?ia??th, ?ioiinoeioeyoe??. sse?noue iaeo?ae?caoe?? aiaeioieneeico iinooia?oueny oae?e i?e aioa?ini?aoe??. 6. O ii?iae?eue a?oie ?eceeo aeieo/aiiy a iinoiia?aoe?eiiio ia??iae? aei o?aaeeoe?eieo caoiae?a i?io?eaeoeee ACO aioa?ini?aaioo “Ea?aia?o” oa eaca?ioa?ai?? noi?iaiaeaeo?oueny iie?auaiiyi naiiii/oooy, i?enei?aiiyi ?iaiethoe?? iaoee, cieaeaiiyi oienai?? oa ?inoii aioeoiene/ii? ?acenoaioiino? ee?oei e?ia?, ei?aeoe??th ?ioiii? ?aaeoeaiino?. Oea i?ecaiaeeoue aei no?eeiai aoaeoo iaeoaeaiiy, nei?i/aiiy oa?i?i?a ia?aaoaaiiy ii?iae?ee? a noaoe?iia??, ciaioaiiy e?eueeino? ai?eii-caiaeueieo oneeaaeiaiue, a i?e ?o aeieeiaii? - aei eaaoiai ia?aa?ao. Oaea i?io?eaeoe/ia i?ia?aia ? aacia/iith aeey ii?iae?eue, ia aeeeeea? oneeaaeiaiue. ?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy aeaee ciiao noi?ioethaaoe ieceo i?aeoe/ieo ?aeiiaiaeaoe?e, aieiaieie c yeeo aaaaea?ii ianooii?. C iaoith i?iaiicoaaiiy aeieeiaiiy oa ?aiiuei? ae?aaiinoeee ACO o i?neyiia?aoe?eiiio ia??iae? ii?iae?eue a?oie ?eceeo, eio?? ia?aianee IE?, ie??i ia?aiao??a ?ioiiiai noaoono aeioe?eueii aecia/aoe ??aaiue aiaeiaaiii? ?ioieneeaoe??. I?e oeueiio aeey anoaiiaeaiiy aaee/eie aiaeioienai?? ?aeiiaiaeo?ii canoiniaoaaoe nia?iaoici?aeiee oano ? ?aaeoe??, ye? aecia/athoue eiioeaio?aoe?th a ne?iaaooe? e?ia? NII. Aeey ae?aaiinoeee aeeaeie aiaeioieneeico aei?a/ieie ? oanoia? ?aaeoe??, iai?aaeai? ia aecia/aiiy ia?aiao??a aioeoiene/ii? ?acenoaioiino? ee?oei e?ia?, noia?ii? oiene/iino? e?ia? oa ?ioa?noeoe?eii? ??aeeie. Aeinoia??i?noue io?eiaieo aeaieo caaacia/o?oueny, o oaeiio aeiaaeeo, ii??aiyiiyi ?c iiiia?aiaie iieaciee?a A? aeey ii?iae?eue Oa?iii?euenueei? noaiiioeyoe??. Ca oiia cieaeaiiy ia?aiao??a ?ioiia?aie i?e ae?aaeai?e aiaeiaaii?e ?ioieneeaoe??, o ii?iae?eue a?oie ?eceeo, eio?? ia?aianee IE?, ?aeiiaiaeo?ii aei aacenieo caoiae?a i?io?eaeoeee aeiaeaoeiai i?ecia/aoe eaca?ioa?ai?th oa aioa?ini?aoe?th. I?e oeueiio iioeiaeueiith ? ianooiia i?ia?aia: - Ii/eiath/e c iaeaeeae/iai i?neyiia?aoe?eiiai ia??iaeo, eaca?ioa?ai?th cae?enithaaoe a oaeee niin?a: Ii?iae?ee? a e?aeeo ciyoe iia’yceo. Cii/eoe i?neyiia?aoe?eio ?aio 3% ?ic/eiii ia?aeeno aiaeith ? ia i?inoooth/e, ii?ii?ieoe eaca?ii. Ia?aaeith /a?aaio no?ieo a i?iaeoe?? i?aaiai oa e?aiai eooa aeia iaoee (i?eaeecii a ae?eyioe? iaeniaeea?a) ii?ii?ithaaoe eaca?ieie i?iiaiyie aia?aoo “E?ea-2” c aeiaaeeiith oaee? 820 ii, aonoeiith iiooaeiino? ia ii?ii?ithaaiiio ia’?eo? 50 iAo/ni2 o aacia?a?aiiio ?aaeei?. Eaca?iee i?ii?iue ni?yiiaoaaoe ia?iaiaeeeoey?ii aei naa?oaeueii? ? i?ae eooii 45 aei ai?eciioaeueii? ieiuei. Oeth i?ioeaaeo?o, ii/eiath/e c 2 aeiae i?ney iia?aoe??, cae?enithaaoe uiaeiy i?ioyaii 3-4 oa, ia eo?n e?eoaaiiy 6-8 ii?ii?iaiue. E??i oiai, aeioe?eueii ii?ii?ithaaoe iaeanoue i?neyiia?aoe?eiiai ?oaoey (ii 1 oa a na?aaei?e oa eaoa?aeueieo /anoeiao) oa iaaeieiioieiai? ae?eyiee (1 oa) ia?iaiaeeeoey?ii aei oe??e. Caaaeueia aeniiceoe?y 10-12 oa. A?aenoaiue a?ae aeaea?aea aei?ii?ithaaiiy aei ia’?eoo 1-2 ni. Iaea?eueo iioeiaeueia aeniiceoe?y 10 oa (ii 1 oa ia iaeia iiea ii?ii?iaiiy a iaeano? i?neyiia?aoe?eiiai ?oaoey ? ii 3 oa a iaeano? i?iaeoe?? aeia iaoee). ?ic/eiii ia?aeeno aiaeith ia?iaeyoe aaciina?aaeiuei ia?aae ii?ii?iaiiyi ae?eyiee, ui aeicaiey? caiia?aoe eiai aeneoaiith (ii 3-5 ie ia eiaeia iiea). - C iiiaioo ae?aaiinoeee aaeaeaaoii? ia?enoaeueoeee i?ecia/aoe aioa?ini?aaio "Ea?aia?o" ii 15 a aeai/i ia aeaiue (i 700 oa i 2300 aiae) i?ioyaii 4-5 aeiia. Ia?aae aaeeaaiiyi ii?oe?th i?aia?aoo caeeoe aiaeith, aeia?a ia?ai?oaoe ? aeieoe, iaaei??ii caieaath/e aiaeith. I?eeii aioa?ini?aaioo iaiaei?iii iiaeiai noi?iaiaeaeoaaoeny eiai aaeaeaaoiith aaaeoaoei?th c o?aaiiai eaiaeo, ui aeinyaa?oueny ei?aeoei?th aei?oe, canoinoaaiiyi ia?i?aeueieo i?iiinieo caniaia /e i?ecia/aiiyi i/enii? eeicie (ye i?aaeei, ia 2 aeiao iiney iia?aoei?). Iio??aii aeiaeaaoeny uiaeaiiiai noieueoey. I?ecia/aoe aioa?ini?aaio ca oiiae aeinoaoiueiai ?iaiy ia’?io oee?eoethth/i? e?ia?. I?ioeiieacaie aeey i?ecia/aiiy eaca?ioa?ai?? ?: ceiye?ni? oa aeia?iye?ni? iooeeie, AeAC-neiae?ii. I?ioeiieacaie aeey i?ecia/aiiy aioa?ini?aaioo "Ea?aia?o" ?: ae?acee oa e?iaioa/? o o?aaiiio eaiae?, ?iaeea?aeoaeueia iaia?aiinei?oue. Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe?? 1. Ie/ee A.C. Aiaeiaaiia ?ioieneeaoe?y o ii?iae?eue c oaeoi?aie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue, ?ic?iaeaeaieo eana?nueeei ?icoeiii //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1997. – ? 9. – N. 19-23. 2. Ie/ee A.C., E?aaaoeue O.A. Iaoiaeieia?/i? i?aeoiaee aei aeai?o ?ioiio?iiieo na?aaeiee?a o ii?iae?eue a?oie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue eana?nueeiai ?icoeio //A?niee iaoeiaeo aeine?aeaeaiue. – 1999. – ? 1. – N. 21-23. 3. Oi?eue N.A., Ie/ee A.C. Aeeiai?ea ?ioiieia?/ieo iieaciee?a o ii?iae?eue c oaeoi?aie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue i?ney eana?nueeiai ?icoeio //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1997. – ? 9. – N. 35-37. 4. Oi?eue N.A., Ie/ee A.C. Aeine?aeaeaiiy ia?aiao??a aiaeiaaiii? ?ioieneeaoe?? ye ee?i?ei-eaai?aoi?iee e?eoa??e i?iaiicoaaiiy i?neyiia?aoe?eieo ai?eii-caiaeueieo oneeaaeiaiue //Oieoaeueia o??o?a?y. – 1999. - ? 2. – N. 76-78. 5. Oi?eue N.A., Ie/ee A.C. Aieea aioa?ini?aoe?? ia ??aaiue aiaeiaaiii? ?ioieneeaoe?? o ii?iae?eue a?oie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue eana?nueeiai ?icoeio //Oe?a?inuee? iaaee/i? a?no?. – 1998. – O. 2, ? 1-2. – N. 62. 6. Iaoiaee aeine?aeaeaiiy aiaeiaaiii? ?ioieneeaoe?? i?aai?cio: Iaoiaee/i? ?aeiiaiaeaoe?? /Aiae?ae/ei I.A., Aao I.Ae., Aeai’yiaiei A.A., Ie/ee A.C., Ie/ee I.A. – Ee?a. - 1998. – 31 n. 7. Aeai’yiaiei A.A., Aao I.Ae., Ie/ee A.C. Aeine?aeaeaiiy aieeao oeueo?ao?ieaoiaiai aei?ii?ithaaiiy ia eiiiiiaioe caiaeueiiai i?ioeano a aenia?eiaio? //I?aeia?iaeia eiioa?aioe?y “Aeooaeuei? ieoaiiy ii?oieia??”. – O. ?. – Oa?iii?eue: Iie?a?ao?no. – 1996. - N. 223-224. 8. Ie/ee A.C. Aiaeiaaiia ?ioieneeaoe?y o aaa?oieo ? ii?iae?eue i?ney iia?aoe?? eana?nueeiai ?icoeio c oaeoi?aie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue //I?aeia?iaeia eiioa?aioe?y “Aeooaeuei? ieoaiiy ii?oieia??”. – O. ??. – Oa?iii?eue: Iie?a?ao?no. – 1996. - N. 466-468. 9. Ie/ee A.C. Aiaeiaaiia ?ioieneeaoe?y oa ?ioiiee noaoon ii?iae?eue c oaeoi?aie ?eceeo aeieeiaiiy ai?eii-caiaeueieo oneeaaeiaiue i?ney iia?aoe?? eana?nueeiai ?icoeio //I?aenoieiaa iaoeiaa eiioa?aioe?y noaeaio?a ? iieiaeeo a/aieo iaae?inoeoooo. – Oa?iii?eue. – 1996. – N. 97-98. 10. Ie/ee A., Oaaeiithe E. Ioe?iea ??aiy aiaeiaaiii? ?ioieneeaoe?? a aeeiai?oe? i?neyiia?aoe?eiiai ia??iaeo ii?iae?eue i?ney eana?nueeiai ?icoeio //? I?aeia?iaeiee eiia?an noaeaio?a ? iieiaeeo a/aieo. – Oa?iii?eue - 1997. – N. 155-156. 11. Oieeue N.A., O?eeeineee A.E., Iu/ee A.C. I?ioeeaeoeea ?aiaaie eioaeoeee iinea iia?aoeee eana?aaa na/aiey n iiiiuueth iaaieoi-eaca?a //Eiia?ann iieiaeuo o/aiuo ii eeeie/aneie iaaeeoeeia. – Eeaa. – 1992. – N. 123. 12. Ie/ee A.C., Oi?eue N.A. Aeiao?ae “Niin?a i?io?eaeoeee ai?eii-caiaeueieo oneeaaeiaiue eana?nueeiai ?icoeio” (cayaea ? 99042451 a?ae 29.04.1999 ?., iiceoeaia ??oaiiy a?ae 11.06.1999 ?.). AIIOAOe?ss Ie/ee A.C. ?ieue aeaoieneeaoe?? oa eaca?ioa?ai?? a eiiieaeni?e i?io?eaeoeoe? ai?eii-caiaeueieo oneeaaeiaiue eana?nueeiai ?icoeio o ii?iae?eue a?oie ?eceeo. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 - aeooa?noai oa a?iaeieia?y. - A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.?. Ie?iaiaa IIC Oe?a?ie, A?iieoey, 1999. ?iaioa i?enay/aia ieoaiiyi i?io?eaeoeee ai?eii-caiaeueieo oneeaaeiaiue eana?nueeiai ?icoeio. Ia iniia? ee?i?/iiai oa eaai?aoi?iiai ianoaaeaiiy 122 ii?iae?eue a?oie ?eceeo anoaiiaeaii, ui i?neyiia?aoe?eiee ia??iae o ieo noi?iaiaeaeoaaany aiaeiaaiiith ?ioieneeaoe??th oa ?ioiinoi?an??th. Iaeneiaeueia ae?aaeaiiy ?iceaae?a aiiainoaco ca io?eiaieie ee?i?/ieie oa eaai?aoi?ieie aeaieie i?eiaaeaei ia 2 aeiao ioa?ia??th. Aeiaeaoeiaa aeeth/aiiy aei eiiieaenii? i?io?eaeoeee aioa?ini?aaioo “Ea?aia?o” oa eieaeueiiai eaca?iiai ii?ii?iaiiy a i?neyiia?aoe?eiiio ia??iae? noi?iaiaeaeoaaeiny iie?auaiiyi naiiii/oooy, nooo?aei ciaioaiiyi ?ioieneeaoe?? i?aai?cio, ni?eyei ii?iae?caoe?? ooieoe?iiaeueiiai noaio ?ioiii? nenoaie, aoaeoeaii caiia?aaei ?icaeoeo ai?eii-caiaeueieo oneeaaeiaiue. Cai?iiiiiaaia i?io?eaeoe/ia i?ia?aia ? aacia/iith aeey ii?iae?eue, ia aeeeeea? oneeaaeiaiue. Eeth/ia? neiaa: ai?eii-caiaeuei? oneeaaeiaiiy, aiaeiaaiia ?ioieneeaoe?y, aioa?ini?aaio, eana?nueeee ?icoei, eaca?ia aei?ii?ithaaiiy. ANNOTATION Nychyk A.Z. The role of detoxication and laser therapy in complex prophylaxis of purulent and inflammatory complication after cesarean section in high risk women. – Manuscript. The thesis for a Master’s degree of medicine in Speciality: 14.01.01. – obstetrics and gynecology. – M.I. Pyrohov Vinnytsia State Medical University, Vinnytsia, 1999. The work is dedicated to cesarean section purulent and inflammatory complication. On the basis of clinical and laboratory research of 122 high risk confined women it has been established endogenic intoxication and immunosuppresion in postoperative period. Maximal homeostasis disturb according to clinical and laboratory data was on the 2 day of the puerperium. Additionally application of “Karbovit” enterosorbent and local laser irradiation in complex prophylaxis in postoperative period leads to feeling improvement, significant reduction of intoxication, normalization of immune system functional state, effective prophylaxis of purulent and inflammatory complication. The proposed prophylactic program is safe for women and has no complications. Key word: cesarean section, endogenic intoxication, enterosorbent, laser irradiation, purulent and inflammatory complication. AIIIOAOeEss Iu/ee A.C. ?ieue aeaoieneeaoeee e eaca?ioa?aiee a eiiieaeniie i?ioeeaeoeea aiieii-ainiaeeoaeueiuo ineiaeiaiee eana?aaa na/aiey o ?iaeaieoe a?oiiu ?enea. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 - aeooa?noai e aeiaeieiaey. - Aeiieoeeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. I.E. Ie?iaiaa IIC Oe?aeiu, Aeiieoea, 1999. ?aaioa iinayuaia aii?inai i?ioeeaeoeee aiieii-ainiaeeoaeueiuo ineiaeiaiee eana?aaa na/aiey. Oeaeue ?aaiou: iiauneoue yooaeoeaiinoue iaoiaaiaoe/aneeo i?ia?aii i?aaeoi?aaeaeaiey aiieii-ainiaeeoaeueiuo ineiaeiaiee (AAI) eana?aaa na/aiey o ?iaeaieoe a?oiiu ?enea iooai ei??aeoeee eiioiiie ?acenoaioiinoe nia?aiaiiuie iaoiaeaie oa?aiee – yioa?ini?aoeeae e eaca?iui iaeo/aieai. A caaea/e enneaaeiaaiey aoiaeeei: 1. O ?iaeaieoe a?oiiu ?enea, iia?e?iaaiiuo eana?aaui na/aieai, enneaaeiaaoue eciaiaiey eiioiiiai noaoona, aeiioaoe/anee naycaiiua n yiaeiaaiiie eioieneeaoeeae (YE). 2. Eco/eoue eeeie/aneoth, eiioiieiae/aneoth e aeaoieneeaoeeiiioth yooaeoeaiinoue i?eiaiaiey yioa?ini?aoeee a eiiieaeniie i?ioeeaeoeea AAI eana?aaa na/aiey o ?iaeaieoe a?oiiu ?enea. 3. Ii?aaeaeeoue aeeyiea eaca?ioa?aiee ia iieacaoaee eiioieoaoa e YE o ?iaeaieoe a?oiiu ?enea. 4. Eco/eoue oeaeaniia?aciinoue eiiaeie?iaaiiiai i?eiaiaiey eio?aei?ii?aeueiie aeaoieneeaoeee e eaca?ioa?aiee n oeaeueth i?aaeoi?aaeaeaiey AAI o ?iaeaieoe a?oiiu ?enea. 5. ?ac?aaioaoue i?aeoe/aneea ?aeiiaiaeaoeee aeey oniaa?oainoaiaaiey iaoiaeia ianeaaeiaaiey ?iaeaieoe e i?ioeeaeoeee AAI eana?aaa na/aiey. Ia o?iaia yiaeioienaiee noaeeee ca ia?aiao?aie nia?iaoicieaeiiai oanoa, ?aaeoeee ii?aaeaeaiey eiioeaio?aoeee n?aaeia iieaeoey?iuo iaioeaeia. Aeoaeio yiaeioieneeica enneaaeiaaee ca ?aaeoeeyie aioeoiene/aneie ?acenoaioiinoe eaeeioeeoia e y?eo?ioeeoia, eaeeioeeoa?iui e aaiaoieiae/aneei eiaeaenaie eioieneeaoeee, noiia?iie oiene/iinoueth e?iae e eioa?noeoeeaeueiie aeeaeeinoe. Eiioiieiae/aneee noaoon ioeaieaaee ca iaeioi?uie ia?aiao?aie eeaoi/iiai e aoii?aeueiiai eiioieoaoa. N oeaeueth eiaeeeaoeee O - e A-eeioioeeoia n o/aoii eo ?acenoaioiinoe e oaioeeeio i?eiaiyee iaoiae eiiaeie?iaaiiiai ?icaoeiia?aciaaiey. I?iecaiaeeee ?an/ao oaioeeeiiaiai eiyooeoeeaioa (niioiioaiea oaioeeei?acenoaioiuo e oaioeeei/oanoaeoaeueiuo Y-?IE), eiyooeoeeaio eiioiinoeioeyoeee e eiyooeoeeaio eiioiiiiaeoeyoeee i?aaeeiaeaiiie oa?aiee. Ii?aaeaeyee eiioeaio?aoeeth nuai?ioi/iuo eiioiiaeiaoeeiia eeannia A, I e G, o?iaaiue oee?eoee?othueo eiioiiuo eiiieaenia (OeEE). Ianeaaeiaaiea i?iaiaeeee ia 2a, 5-6a, 9-11a nooee iineaiia?aoeeiiiiai ia?eiaea. Ia iniiaaiee eeeie/aneiai e eaai?aoi?iiai ianeaaeiaaiey 122 ?iaeaieoe a?oiiu ?enea onoaiiaeaii, /oi eo iineaiia?aoeeiiiue ia?eiae nii?iaiaeaeaeny YE n iaeneiaeueiie au?aaeaiiinoueth ia 2 nooee ioy?ia?ey. I?eciaee yiaeioieneeica nio?aiyeenue e 9-11 nooeai iinea iia?aoeee. I?e iaieoanoaoeee YE a aeeaeaeoai iineaiia?aoeeiiiii ia?eiaea (2 nooee) o ?iaeaieoe a?oiiu ?enea, eioi?ua ia?aianee eana?aai na/aiea, eiinoaoe?iaaee eciaiaiey eiioiiie nenoaiu: nieaeaiea /enea Y-?IE, oaaee/aiea eiee/anoaa ooieoeeiiaeueii-iaiieiioeaiiuo iaeiaeeooa?aioee?iaaiiuo eeioioeeoia, oaaee/aiea eiioeaio?aoeee OeEE. Iaia?oaeaiiay caaeneiinoue iaaeaeo iaeioi?uie iieacaoaeyie YE e eiioieoaoa aeaao iniiaaiea ?anoeaieaaoue yoe ?anno?ienoaa eae iaoaaiee/aneoth eiioiinoi?anneth. I?iaaaeaia n?aaieoaeueiay eeeieei-eaai?aoi?iay ioeaiea iaoiaeia i?ioeeaeoeee AAI eana?aaa na/aiey. Anao ianeaaeiaaiiuo ?iaeaieoe n aunieei eioaeoeeiiiui ?eneii ?acaeaeeee ia /aou?a ?aiaeiiece?iaaiiua a?oiiu. I?aaenoaaeoaeyi eaaeaeie ec a?oii iacia/aee aacenioth oa?aieth eee ia aa oiia i?eiaiyee ia?i?aeueiue i?eai ni?aaioa, eaca?iia iaeo/aiea eeai eo ni/aoaiea. Aeiiieiaiea iauai?eciaiiuo i?ia?aii i?ioeeaeoeee AAI yioa?ini?aaioii “Ea?aiaeo” iiauoaao eo yooaeoeaiinoue. Iaeiaei aeinoaoi/iie iaeo?aeecaoeee YE e eiioiinoeioeyoeee i?e yoii ia ioia/aii. Aaeaaeiaaiay ianoiay (a iaeanoe iineaiia?aoeeiiiie ?aiu) eaca?ioa?aiey niinianoaiaaea ii?iaeecaoeee eeeie/aneeo ia?aiao?ia ioy?ia?ey, eiioiinoeioeyoeee. Ea/anoai iaeo?aeecaoeee yiaeioieneeica iiaeiaiui niiniaii onooiaei oaeiaiio i?e yioa?ini?aoeee. Aeiiieieoaeueiia aeeth/aiea a eiiieaenioth noaio i?ioeeaeoeee yioa?ini?aaioa “Ea?aiaeo” e eieaeueiiai eaca?iiai iaeo/aiey a iineaiia?aoeeiiiii ia?eiaea nii?iaiaeaeaeinue oeo/oaieai naii/oanoaey, nouanoaaiiui oiaiueoaieai eioieneeaoeee i?aaiecia, niinianoaiaaei ii?iaeecaoeee ooieoeeiiaeueiiai ninoiyiey eiioiiie nenoaiu, yooaeoeaii i?aaeoi?aaeaeaei ?acaeoea AAI. I?aaeeiaeaiiay i?ioeeaeoe/aneay i?ia?aiia aaciiania aeey ?iaeaieoe, ia aucuaaao ineiaeiaiee. Eeth/aaua neiaa: aiieii-ainiaeeoaeueiua ineiaeiaiey, yiaeiaaiiay eioieneeaoeey, yioa?ini?aaio, eana?aai na/aiea, eaca?iia iaeo/aiea. Aaoi? aeiineoue ue?o iiaeyeo aeioeaioo eaoaae?e oieoaeueii? o??o?a?? Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss. Ai?aa/aanueeiai e.i.i. Aaoo Ieeie? Aeieo?iae/o ca aeiiiiiao i?e aeai?? iaoeiaiai iai?yieo oa i?aeo?eieo.

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