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Рання діагностика діабетичних нефропатій у хворих на інсулінзалежний цукровий діабет: Автореф. дис… канд. мед. наук / О.Ч. Таджієва, Ін-т ендокринол

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10

?INOEOOO AIAeIE?EIIEIA?? OA IAI?IO ?A*IAEI

?i. A. I. Eii?na?aiea

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

OAAeAE??AA Iaoeueaeaea?ai *a?eeoe??aia

OAeE 616.379-008. 64: 616.61] – 07

?AIIss Ae?AAIINOEEA Ae?AAAOE*IEO IAO?IIAO?E O OAI?EO

IA ?INOE?ICAEAAEIEE OeOE?IAEE Ae?AAAO

14.01.14 – aiaeie?eiieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? aiaeie?eiieia?? oa iai?io ?a/iaei

?i. A. I. Eii?na?aiea AII Oe?a?ie, i.Ee?a, oa a ?inoeooo? aa?iioieia??
AII Oe?a?ie

Iaoeiaee ea??aiee:

Aeieoi? iaaee/ieo iaoe, i?ioani?, aeaaeai?e IAI ? AII Oe?a?ie ?o?iia
Aiae??e Naiaiiae/, ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I.
Eii?na?aiea AII Oe?a?ie, i.Ee?a, caa?aeoaa/ ae?aaaoieia?/iiai a?aeae?eo.

Io?oe?ei? iiiiaioe:

Aeieoi? iaaee/ieo iaoe, i?ioani? Aiaeia? Iao?i Ieeieaeiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I. I. Aiaiiieueoey, i. Ee?a,
caa?aeoaa/ eaoaae?e aiaeie?eiieia??.

Eaiaeeaeao iaaee/ieo iaoe aeioeaio ?iiaiaiei Aaeaioeia Aioii?aia,
Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe

?i. I. E. Ooieea, aeioeaio eaoaae?e ?aae?ieia??.

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
eaoaae?a aiaeie?eiieia??

Caoeno a?aeaoaeaoueny “2” eenoiiaaea 1999 ?. i 13°° aiae. ia can?aeaii?
niaoe?ae?ciaaii? A/aii? ?aaee Ae.26.558.01 c aiaeie?eiieia?? a ?inoeooo?
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a-114, aoe. Aeoai?iaenueea, 69)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a-114, aoe. Aeoai?iaenueea, 69)

Aaoi?aoa?ao ?ic?neaiee “__2__” _____aeiaoiy__________ 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? A/aii? ?aaee

aeieoi? a?ieia?/ieo iaoe
E. I. Eaeeinueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue ?iaioe. Ae?aaaoe/ia iao?iiao?y (AeI) caeia? i?ia?aeia
i?noea na?aae i?e/ei nia?oiino? oai?eo ia oeoe?iaee ae?aaao (OeAe) I
oeio. *anoioa ?icaeoeo AeI neeaaea? 40-50% o oai?eo ia I oei ? 15 – 30%
– o oai?eo ia II oei ae?aaaoo (Oanoaeiaa I.A., 1995, 1998; Osterby R.,
1995; Mogensen C. E. 1999). Iaaaciaea oeueiai oneeaaeiaiiy iieyaa? o
aeineoue iia?eueiiio ? iinooiiaiio ?icaeoeo AeI, yea aeiaaee /an
caeeoa?oueny iaiii?/aiith, ine?eueee ia i?iyaey?ony ee?i?/ii. ? o?eueee
aaea i?e ae?aaeai?e noaae?? o?aaeaiiy ie?ie o oai?iai aeyaey?ony
ee?i?/ia neiioiiaoeea, aea ia oeueiio aoai? ?aaeeeaeueii aeiiiiiaoe
iaoe??ioo ia caaaeaee iiaeeeai.

Ia?o? o?e noaae?? AeI, ca eeaneo?eaoe??th N. A. Mogensen (1983), ia
ae?aaiinoothoueny i?e noaiaea?oiiio ianoaaeaii? oai?iai, aea, o?eueee
oe? noaae?? ? cai?ioieie i?e nai?/ani?e ae?aaiinoeoe?. Iiyaa i?ioa?io???
– ia?oi? ?ooeiii? eaai?aoi?ii? iciaee AeI – na?ae/eoue oaea i?i aeeaiea
? iacai?ioia o?aaeaiiy ie?ie. Ioaea, aeey iiia?aaeaeaiiy ?icaeoeo ?
oaeaeeiai i?ia?anoaaiiy ae?aaaoe/iiai o?aaeaiiy ie?ie iaiao?aeii aeoeaii
aeyaeyoe ?aii? noaae?? AeI. ?acii c oei iei? ia ?nio?
caaaeueiii?eeiyoeo, ?ioi?iaoeaieo iaoiae?a aeyaeaiiy ?aii?o noaee?i?/ieo
noaae?e o?aaeaiiy ie?ie o oai?eo ia OeAe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie. Aeine?aeaeaiiy ? o?aaiaioii
iaoeiai-aeine?aeii? ?iaioe ae?aaaoieia?/iiai a?aeae?eo ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII
Oe?a?ie o 1997-1999 ??. ca oaiith

“Aea/aiiy iiaeo iaoiae?a e?eoaaiiy oeoe?iaiai ae?aaaoo ? eiai
oneeaaeiaiue” (iiia? aea?aeaaii? ?a?no?aoe?? ? 273 ).

Iaoa aeine?aeaeaiiy. Aeyaeoe ? ioa?aeoa?ecoaaoe ?aii? aeiee?i?/i?
noaae?? ?icaeoeo AeI o oai?eo ia OeAe I oeio oa ?ic?iaeoe iaoiaee ?o
?aiiuei? ae?aaiinoeee.

Caaaeaiiy aeine?aeaeaiiy:

1. Aea/eoe o?eueo?aoe?eii-aene?aoi?io ooieoe?th ie?ie o oai?eo ia OeAe I
oeio c ??cieie noaae?yie AeI.

2. Ioe?ieoe noai ie?eiaiai e?iaioieo o iaoe??io?a c ?aii?ie noaae?yie
AeI.

3. Aeine?aeeoe iiaeeea?noue aeei?enoaiiy iaaeeeaiaioicieo i?ia c
?iaeiiaoaoeeiii ? eaioii?eeii aeey aeyaeaiiy noaee?i?/ieo noaae?e AeI.

4. Aeyaeoe iayai?noue aooiaioeo?e aei aacaeueii? iaia?aie eeoai/e?a
(AIE) ie?ie o iaoe??io?a c ??cieie noaae?yie AeI ? c’ynoaaoe cia/aiiy
aooi?ioiieo iaoai?ci?a o oi?ioaaii? oa i?ia?anoaaii? o?aaeaiiy ie?ie o
oai?eo ia ?inoe?icaeaaeiee oeoe?iaee ae?aaao (?COeAe).

5. Ioe?ieoe noai aoii?aeueiiai ?ioi?oaoo o oai?eo ia OeAe I oeio c
??cieie noaae?yie AeI oeyoii aecia/aiiy ?ioiiaeiaoe?i?a ??cieo eean?a ?
?o ni?aa?aeiioaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Iaea?aeai? iia? a?aeiiino? i?i
iniaeeaino? ci?i o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie, ie?eiai?
aaiiaeeiai?ee, ye? i?iyaeythoueny ye ??ciiiai?aaeai? ci?ie oaeeeiiiai
ia’?io eeoai/eiai? o?eueo?aoe??, /ano iaeneiaeueiiai iaeiie/aiiy, /ano
iai?aaeaaaeaiiy ?aae?ioa?ii?aia?aoo, ciaioaiiy oaeaeeino? ie?eiaiai
e?iaioieo ? a?aeiinii? aaiicii? ?iiino? ie?ie o oai?eo c aeiee?i?/ieie
noaae?yie AeI.

Aia?oa ia oe? iaaeeeaiaioicieo i?ia c ?ia?a?oi?ii
aia?ioaiceiia?aoai?thth/iai oa?iaioo (AIO) – eaioii?eeii, ianoa?i?aeiei
i?ioecaiaeueiui i?aia?aoii – ?iaeiiaoaoeeiii, aea/aii oa?aeoa? ci?i
ia?oe?aeueieo ooieoe?e ? aaiiaeeiai?/ieo iieaciee?a ie?ie ia ?aii?o
noaae?yo ?icaeoeo AeI o oai?eo ia I oei OeAe. Iieacaii, ui aeey oai?eo
ia OeAe I oeio c iayai?noth iao?iiao?? oa?aeoa?iei ? ii?ooaiiy
aaeaeaaoii? ?aaeoe?? ia ?iaeiiaoaoeei, ui i?iyaey?oueny a iiaeaeueoiio
ia?inoaii? oaeaeeino? eeoai/eiai? o?eueo?aoe?? (OEO), i?e/iio oe?
ii?ooaiiy ?icaeaathoueny ia ?aii?o noaae?yo iao?iiao??. Anoaiiaeaii, ui
ci?ie ia?aiao??a ie?eiai? aaiiaeeiai?ee o a?aeiia?aeue ia aaaaeaiiy
eaioii?eeo caeaaeaoue a?ae noaae?? AeI ? iiaeooue a?aeia?aaeaoe
?aaeoeai?noue aeiia?oey?ii? aaiiaeeiai?ee.

Aia?oa ioa?aeoa?eciaaii noai aoii?aeueiiai ?ioi?oaoo, aeyaeai?
iniaeeaino? i?iaeoeoe?? ?ioiiaeiaoe?i?a ??cieo eean?a, aioeo?e aei AIE
ie?ie o oai?eo c ??cieie, o oiio /ene? aeiee?i?/ieie, noaae?yie AeI.

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue iiaeeaeai? oyaeaiiy i?i
iaoio?c?ieia?/i? iaoai?cie oi?ioaaiiy ?aii?o noaae?e o?aaeaiiy ie?ie o
oai?eo ia ?COeAe.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeai? i?aeoe/i?
i?aeoiaee ? iaoiaee aeyaeaiiy ?aii?o, noaee?i?/ieo noaae?e AeI o in?a c
I oeiii OeAe. C oe??th iaoith ?aeiiaiaeo?oueny aeei?enoaiiy iaoiaeo
aeeiai?/ii? ?aiinoeeioea?ao?? c iaioaoaoii, yeee aeicaiey? aeyaeoe ci?ie
e?iaioieo, ia?oe?aeueieo ooieoe?e ie?ie o oai?eo ia OeAe aac ee?i?/ieo
iciae AeI.

Aeei?enoaiiy eaioii?eeiai? i?iae aeicaiey? ioe?ieoe ?aaeoeai?noue
ie?eiai? aaiiaeeiai?ee ? ? ?ioi?iaoeaiei aeey i?iaiico aoaeoeaiino?
o?eaaei? oa?ai?? ?ia?a?oi?aie AIO.

Anoaiiaeaii, ui ii?ooaia ?aaeoe?y ia ?iaeiiaoaoeei, yea i?iyaey?oueny
c?inoaiiyi ii/aoeiai i?aeaeuaii? OEO, ? oa?aeoa?iith iciaeith ?aii?o
noaae?e AeI.

Ciaeaeaii, ui iai?yia aia?ia?ao?y ? ?ioi?iaoeaiei iaoiaeii aeyaeaiiy
ii?ooaiue ie?eiai? aaiiaeeiai?ee o oai?eo ia OeAe aac ee?i?/ii
ae?aaeaii? AeI.

?ic?iaeai? i?aeoiaee aei ae?aaiinoeee AeI o oai?eo ia I oei ae?aaaoo
ai?iaaaeaeai? o ee?i?/io i?aeoeeo ae?aaaoieia?/iiai a?aeae?eo ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie:
aeei?enoiaoaaeanue iaaeeeaiaioicia i?iaa c ?iaeiiaoaoeeiii aeey
aeyaeaiiy ii?ooaiue eeoai/eiai? o?eueo?aoe?? ? nooiaiy
i?e?iaeueaoi?io???, aeeiai?/ia ?aiinoeeioea?ao?y ? ?aae?iioee?aeia
aia?ia?ao?y ie?ie c eaioii?eeii ? ?o ioe?iea c o?aooaaiiyi ee?i?/ieo
neiioii?a.

Oai?aoe/i? iieiaeaiiy aeena?oaoe?eii? ?iaioe caeo/ai? aei eaeoe?eiiai
eo?no caiyoue ia eaoaae?? aiaeie?eiieia?? Oo?eiainueeiai aea?aeaaiiai
iaaee/iiai ?inoeoooo, ia eaoaae?? oaeineiiaeaiiy e?ea??a o Ee?anuee?e
iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I. E. Ooieea.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aeeiiaii: ee?i?/ia
ianoaaeaiiy oai?eo, iaaeeeaiaioicia i?iaa c ?iaeiiaoaoeeiii, noaoenoe/ia
ia?iaea ? iaoeiaa ?ioa?i?aoaoe?y io?eiaieo aeaieo. Aeeiai?/ia
?aiinoeeioea?ao?y, ?aae?iioee?aeia aia?ia?ao?y oa iaaeeeaiaioicia i?iaa
c eaioii?eeii i?iaaaeaia ca o/anoth ae. i. i., i?ioanni?a Neaaiiaa A.
I., aecia/aiiy aioeo?e aei AIE oa ?ioiiaeiaoe?i?a e?ia? i?iaaaeaii ca
o/anoth e. a. i., noa?oiai iaoeiaiai ni?a?ia?oieea eaai?aoi???
iaoio?c?ieia?? oa ?ioiieia?? ?inoeoooo aa?iioieia?? AII Oe?a?ie Ieoaeue
E. I.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ia eiioa?aioe?? ae?aaaoieia?/iiai a?aeae?eo ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea o i. Ee?a?, ia
can?aeaii? eaoaae?e aiaeie?eiieia?? Oo?eiainueeiai aea?aeaaiiai
iaaee/iiai ?inoeoooo (1998), ia can?aeaii? ai?iaaoe?eii? eii?n?? c
ee?i?/ii? aiaeie?eiieia?? ?inoeoooo aiaeie?eiieia?? oa iai?io ?a/iaei
?i. A. I. Eii?na?aiea AII Oe?a?ie (1999).

Ioae?eaoe?y ?acoeueoao?a aeine?aeaeaiiy. ?acoeueoaoe aeena?oaoe??
iioae?eiaai? a 5 noaooyo o oeaio?aeueieo oaoiaeo aeaeaiiyo, 3 noaoo? – o
ni?aaaoi?noa? ? 2 – naiino?ei?.

Ia’?i ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 168 noi??ieao
iaoeiiieniiai oaenoo. Neeaaea?oueny ?c anooio, ?icae?e?a: iaeyae
e?oa?aoo?e, iaoa??aee ? iaoiaee aeine?aeaeaiiy, 5 ?icae?e?a iniaenoeo
aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e ia 142 noi??ieao, nieneo e?oa?aoo?e ia 26 noi??ieao, yeee
i?noeoue 256 aeaea?ae (94 a?o/eciyieo aaoi??a ? 162 caei?aeiiieo).
?iaioa ?ethno?iaaia 19 oaaeeoeyie ? 26 iaethieaie.

CI?NO ?IAIOE

Caaaeueia oa?aeoa?enoeea oai?eo ? iaoiaee ?o ianoaaeaiiy

Aoei ianoaaeaii 153 oai?eo ia OeAe ? oeio, ye? ciaoiaeeeenue ia
e?eoaaii? a ae?aaaoieia?/iii a?aeae?e? ?inoeoooa aiaeie?eiieia?? oa
iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie. Eiio?ieueia a?oia
neeaaeaeanue ?c 32 caei?iaeo in?a, o yeeo i?e ianoaaeaii? cia/aiiy
ae?eiceeueiaaiiai aaiiaeia?io noaiiaeei a?ae 3,3% aei 5,5%, aoee
a?aenooi?ie iciaee iaoieia?? c aieo ie?ie ? na/aaea?aeieo oeyo?a, ia
aoei a?ia?oii?/ii? oai?iae, aeeeth/aia niaaeeiaa iaoyaeaiiy uiaei
oeoe?iaiai ae?aaaoo.

O oe?e ?iaio? ooieoe?iiaeueiee noai ie?ie o oai?eo ia OeAe I oeio
aea/aany ca aeiiiiiaith a?io?i?/ieo, ?aae?i?cioiiieo,
?ioiioeoi?anoeaioiiai ? ?aae?aeueiiai ?ioiiaeeoociiai iaoiae?a
aeine?aeaeaiiy.

Aeey aecia/aiiy noaio o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie,
aea/aiiy aieeao i?eeiio iaeii?aciai? aeice eaioii?eeo ia ooieoe?iiaeuei?
iieacieee ie?ie o 24 oai?eo ia OeAe ? oeio ? o 12 caei?iaeo in?a, ye?
neeaaeaee eiio?ieueio a?oio, i?iaaaeaia aeeiai?/ia ?aiinoeeioea?ao?y ?
?aae?iioee?aeia aia?ia?ao?y ie?ie ia noeeioeeyoe?ei?e aaiia-eaia?? IA
9200 c nenoaiith aaoiiaoe/ii? ia?iaee MICROSEGAMS (Oai?ueia).
Ianoaaeaiiy i?iaiaeeee ca aeiiiiiaith iao?io?iiiiai i?aia?aoo –
aeeaoee?io?eaieiiaioaaoeaoaoo (AeOIA), i?/aiiai ei?ioeiaeeao/ei
?aae?iioee?aeii 99m-On (oaoiaoe??i), yeee aeaiaeeoueny ?c i?aai?cio
ie?eaie ? oaeaee?noue aeaaaeaiiy yeiai caeaaeeoue a?ae aaee/eie
eeoai/eiai? o?eueo?aoe??. Aecia/aiiy oaeeeiiiai ia’?io eeoai/eiai?
o?eueo?aoe?? (OIEO) i?iaiaeeee ca e?eaith i/euaiiy e?ia? a?ae 99m-On
AeOIA, c ?aa?no?aoe??th aeoeaiino? ?cioiio ia 15-e, 24-e ? 28-e oa. Aeey
ioe?iee ie?eiaiai e?iaioieo ca ?aae?iaia?ia?aiith aeei?enoiaoaaee oae?
iieacieee: 1. *an a?oa??aeueiiai i?eieeao (Oa) – ia?ao?ae a?ae ii/aoeo
i?aeeiio e?eai? aei iaeneioio (n). 2. *an aaiiciiai a?aeoieo (Oa) – a?ae
iaeneiaeueiiai i?aeeiio e?eai? aei aeoiaeo ia ieaoi (n). 3. A?aeiinia
aaiicia ?ii?noue (A/A) – a?aeiioaiiy Oa aei Oa.

I?ney aecia/aiiy aeo?aeieo iieaciee?a ooieoe?iiaeueiiai noaio ie?ie,
iiaoi?ia aeine?aeaeaiiy i?iaiaeeee ianooiii? aeiae, /a?ac 2 aiae. i?ney
i?eeiio 25 ia eaioii?eeo – ?ia?a?oi?a AIO.

Aeey ioe?iee noaio ooieoe?? ie?ie o 60 oai?eo ia OeAe I oeio aac yaieo
ee?i?/ieo iciae AeI i?iaaaeaia iaaeeeaiaioicia i?iaa c ?iaeiiaoaoeeiii c
aecia/aiiyi oaeaeeino? eeoai/eiai? o?eueo?aoe?? ca ee??ainii
aiaeiaaiiiai e?aaoei?io. Aeey aeine?aeaeaiiy iiaeeeaino? aeei?enoaiiy
aeaiiai iaoiaeo aeey ?aiiuei? ae?aaiinoeee noaee?i?/ieo noaae?e AeI
oaeaeeinoue eeoai/eiai? o?eueo?aoe?? aecia/aee aea?/? – aei ? i?ney
i?eeiio ?iaeiiaoaoeeio, ca iaoiaeii ?aaa?aa-Oa???aa, ca ee??ainii
aiaeiaaiiiai e?aaoei?io a ia?a?aooieo ia noaiaea?oio iiaa?oith o?ea.
A?aeiia?aeue ia ?iaeiiaoaoeeiiao i?iao (?I) o?aeooaaeanue ye aaeaeaaoia
i?e cieaeaii? aeo?aeii? i?aeaeuaii? OEO aei 10 %, iaaaeaeaaoia – i?e
i?aeaeuaii? OEO aei 10 % ? a?eueoa. I?e?iaeueaoi?io??th (IAO)
ioe?ithaaee ca aeiiiiiaith oano–nioaeie o??ie Boehringer Mannheim
“Micral-Test-II” ? oano-nioaeie o??ie “Bayer” Albustix, 3-4 ?ace
i?ioyaii 2 oeaei?a.

Oai?? c aino?eie ?ioaeoe?yie na/inoaoaaiai o?aeoo, o?ii?/iith
iaaeinoaoi?noth e?iaiia?ao, caoai?thaaiiyie aaiaoia?e?a?ii? nenoaie, ui
io?eioaaee ei?oeeinoa?i?aeio oa ?ioiiaeai?aneaio oa?ai?th, oai?? c
a?oa??aeueiith a?ia?oaic??th (nenoie?/iee AO aeua 150 ii ?o no.,
na?aaei?e AO aeua 106 ii ?o. no.), ui ?ai?oa io?eioaaee a?iioaiceai?
i?aia?aoe, ?ia?a?oi?e AIO, ia aeeth/aeenue a ianoaaeaiiy c
iaaeeeaiaioiciith i?iaith ia eaioii?ee.

I?iaaaeaii aeine?aeaeaiiy ai?noo aooiaioeo?e aei AIE ie?ie ?
aecia/aiiy a e?ia? ??aiy ?ioiiaeiaoe?i?a eeano G, D, A, M o 69
oai?eo ia ?COeAe c ??cieie noaae?yie AeI.

Iayai?noue aooiaioeo?e aei AIE ie?ie o ne?iaaooe? e?ia? oai?eo
ioe?ithaaee ca i?enooiino? niaoeeo?/iiai na?o?iiy iaia?aie ie?ee iaaie
i?ney ?ieoaaoe?? noaiaea?oieo c??c?a (The Binding Site LTD, England) c
aeine?aeaeoaaiith ne?iaaoeith oai?iai ? ianooiiiai ?ioiioeoi?anoeaioiiai
caaa?aeaiiy aioeo?eaie aei ?ioiiaeiaoe?i?a ethaeeie, i?/aieo
oeoi?anoea?i?cio?ioeeiiaoii (O?OOe) (The Binding Site LTD, England).

??aaiue ?ioiiaeiaoe?i?a (Ig) eean?a G, M, A, D o ne?iaaooe? e?ia?
aecia/aee iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ca aeiiiiiaith
noaiaea?oieo iaai??a IDP CEBAK (?anioae?ea *ao?y). Iaoiae
a?oioo?oueny ia caeaoiino? niaoeeo?/ieo aioeo?e i?e ca’ycoaaii? c
aioeaaiii ooai?thaaoe aeaeei? i/eia e?eueoey i?aoeei?oaoe?? a
aaa?iaiio aae? (Mancini G. et al., 1970).

Noaoenoe/io ia?iaeo aeaieo i?iaiaeeee iaoiaeaie aa??aoe?eii? ?
iieniai? noaoenoeee c aeiiiiiaith noaiaea?oiiai iaeaoo
noaoenoe/iiai ?ic?aooieo aeaieo Microsoft Excel ia ia?niiaeueiiio
eiii’thoa?? Pentium-233. A??ia?aei?noue ??cieoe? na?aaei?o aaee/ei
aecia/aee ca t -e?eoa???i Nouethaeaioa ? ca t-e?eoa???i O?oa?a
(aeey a?aeiinieo aaee/ei). ??cieoeth aaaaeaee a??ia?aeiith i?e ?
? 0,5.

Ooieoe?iiaeuei? iieacieee ie?ie aei ? i?ney i?eeiio eaioii?eeo, ca
aeaieie ?aiinoeeioea?ao??, o in?a eiio?ieueii? a?oie oaeiae ia caciaaaee
nooo?aeo ci?i. Oae, Oiaen. ia eiii’thoa?ieo ?aiia?aiao aoei i?aeoe/ii
iaeiaeiaei o e?a?e ? i?aa?e ie?eao aei ? i?ney iaaeeeaiaioiciiai
iaaaioaaeaiiy a?aeiia?aeii 2,9 ± 0,6 oa, 3,0 ± 0,6 oa; ? 3,0± 0,6 oa,
3,0± 0,6 oa (? > 0,5). *an iai?aaeaaaeaiiy ?aae?i?iaeeeaoi?a ?c ie?ie
(O1/2), yeee oa?aeoa?eco? oaeaee?noue aene?aoi?ieo i?ioean?a o in?a
eiio?ieueii? a?oie aei ? i?ney eaioii?eeo ia ci?ithaaany, a?aeiia?aeii:
o e?a?e ? i?aa?e ie?eao 12 ± 2,6 oa, 10 ± 2,6 oa; ? 10,0±2,6 oa,
11,0±2,6 oa, (? > 0,5). Ca aeaieie aecia/aiiy oaeeeiiiai ia’?io
eeoai/eiai? o?eueo?aoe?? ? IAO, o an?o oai?eo anoaiiaeai? aeiee?i?/i?
noaae?? AeI. O 10 oai?eo ae?aaiinoiaaia AeI II noaae??, o 14 AeI III
noaae??.

Iaie ciaeaeaia ??cieoey a ?aaeoe?? OIEO ia eaioii?ee na?aae aeaio
aeae?eaieo a?oiao. O oai?eo c AeI II noaae?? ii/aoeiai i?aeaeuaiee OIEO,
yeee a na?aaeiueiio ii a?oi? neeaaeaa 171 ± 16,2 ie/oa, cieceany aei 134
± 8,2 ie/oa. Cieaeaiiy OIEO a?aeiia?aeaei 27,6% ? aoei noaoenoe/ii
a??ia?aeiei (? 0,05).

Oiaen. o oai?eo c AeI II nooiaiy a?aeiia?aeii aeey e?ai? ? i?aai? ie?ee,
noaiiaea: aei i?iae – 5,0 ± 0,8 oa ? 6,0 ± 0,8 oa, i?ney – 4,1 ± 0,2 oa
? 4,3 ± 0,5 oa (P > 0,05); o oai?eo c AeI III noaae??: Oiaen. aei i?iae
– 4,9 ± 0,4 oa, ? 5,9 ± 0,8 oa, i?ney 4,1 ± 0,4 oa, ? 4,7 ± 0,9 oa (P >
0,05).

Aeayea iiceoeaia aeeiai?ea niinoa??aaeanue c aieo /ano
iai?aaeaaaeaiiy (O1/2)

99m On-AeOIA ?c ie?ie. Oea ae?aaeaeinue o ciaioaii? iieacieea O1/2 ye
iciaee i?enei?aiiy aene?aoi?ii? ooieoe??. Ia?a?nii cia/ii niia?eueiaiee
/an iai?aaeaaaeaiiy O1/2 ?c ie?ie o iaoe??io?a iaio ee?i?/ieo a?oi i?ney
i?eeiio eaioii?eeo iii??ii i?enei?thaaany. Iaeiae, ye ? ?ai?oa,
caa??aaeanue nooo?aa noaoenoe/ii cia/eia ??cieoey c ii?iith (P 0,05); o oai?eo c AeI III noaae??
O1/2 a?aeiia?aeii aeey e?ai? ? i?aai? ie?ee i?ney eaioii?eeo iacia/ii
ciaioeany ( c 32,8 ± 3,9 oa ? 32,6 ± 4,2 oa aei 27,0 ± 4,1 oa ? 28,8 ±
4,0 oa, (P > 0,05).

Iaie i?inoaaeaia oaeiae ?aaeoe?y c aieo iieaciee?a ie?eiai?
aaiiaeeiai?ee ca aeaieie ?aae?iioee?aeii? aia?ia?ao?? ia iaeii?aciaee
i?eeii 25 ia eaioii?eeo o in?a eiio?ieueii? a?oie ? o oai?eo c AeI II ?
III noaae?e. sse iieaco? aiae?c, ia oe? iaaeeeaiaioiciiai iaaaioaaeaiiy
ia aeyaeaii nooo?aeo ci?i iieaciee?a a?oa??aeueiiai i?eieeao ? aaiiciiai
a?aeoieo o in?a eiio?ieueii? a?oie. Iieacieee – Oa, Oa ? AA? caeeoaeenue
o iaaeao ii?iaeueieo aaee/ei.

*an a?oa??aeueiiai i?eieeao (Oa) aeey e?ai? ? i?aai? ie?ee o oai?eo c
AeI II noaae?? i?ney aaaaeaiiy eaioii?eeo ia ci?ithaaany (aei – 15,2 ±
1,4 n. ? 15,1 ± 1,3 n, i?ney – 13,1 ± 0,5 n ? 13,4 ± 0,4 nae, (P >
0,05); o oai?eo c AeI III noaae??, a?aeiia?aeii noaiiaea: aei – 18,8 ±
1,5 n ? 18,6 ± 1,3 n, i?ney – 14,5 ± 1,2 n ? 14,8 ± 1,6n, (P > 0,05);
i?e cia/aii? aeaiiai iieacieea o eiio?ieuei?e a?oi? aeey e?ai? ? i?aai?
ie?ee – 9,0± 0,5 n ? 8,1 ± 0,4 n, (P 0,5) a iaio a?oiao oai?eo, caeeoath/enue
nooo?ai oiia?eueiaiei ii??aiyii c ii?iith (P 0,5); i?e cia/aii? aeaiiai iieacieea o
eiio?ieuei?e a?oi? aeey e?ai? ? i?aai? ie?ee 6,7± 0,3 n ? 6,4 ± 0,4 n,
(P 0,5). Iaaiith i??ith
oea iiaea aooe ca’ycaii c oei, ui o /anoeie oai?eo iaio a?oi i?e
ia?aeiiiio ianoaaeaii? a?aei?/aeinue ??cea ii?ooaiiy aaiiciiai a?aeoieo
o aeaeyae? aaiiciiai noaca.

Noai ie?eiai? aaiiaeeiai?ee, ui niinoa??aaany o a?oi? oai?eo c AeI II
noaae??, noi?iaiaeaeoaaany i?aeaeuaiiyi AA?, a?aeiia?aeii a e?a?e ?
i?aa?e ie?oe?: aei eaioii?eeo – 0,84 ± 0,09 ? 0,82 ± 0,07, i?ney – 1,1 ±
0,03 ? 1,2 ± 0,05, i?ioa oe? ci?ie ia aoee a??ia?aeieie (P > 0,05).
Aiaeia?/ia ea?oeia AA? a?aecia/aeany o oai?eo c AeI III noaae??. AA? o
e?a?e ? i?aa?e ie?oe? aei i?eeiio eaioii?eeo neeaea 0,86 ± 0,14 ? 0,86 ±
0,12, i?ney – 0,98 ± 0,14 ? 0,97 ± 0,12 (P>0,2), oiaoi i?ae aieeaii
eaioii?eeo AA? ia ci?ieeanue. Oaeei /eiii, ye iieacaee i?iaaaeai?
aeine?aeaeaiiy, eaioii?ee ia? ae?aaeaiee aieea ia ooieoe?iiaeuei?
iieacieee ie?ie o oai?eo c AeI: cieaeo? ii/aoeiai cia/ii i?aeaeuaiee
OIEO o oai?eo c AeI II noaae?? ? ca?eueoo? iii??ii i?aeaeuaiee OIEO o
oai?eo c AeI III noaae??. Iiaeia i?eionoeoe, ui a?eueo ?aii? ci?ie
ooieoe?iiaeueieo iieaciee?a ie?ie, ui i?iyaeythoueny o aeaeyae? AeI II
noaae??, a?eueo /ooeea? aei ii?iae?coth/i? ae?? eaioii?eeo ii??aiyii c?
ci?iaie o oai?eo c a?eueo ae?aaeaiith AeI III noaae??. Ia aeeaey/enue ia
a oe?eiio iiceoeaio iai?aaeaii?noue, ci?ie iieaciee?a
aioo??oiueiie?eiaiai o?ainii?oo ? ie?eiai? aaiiaeeiai?ee caeeoaeenue
ii?ooaieie ? ia ei?aaoaaeenue iiai?noth iaeii?aciaei i?eeiiii
eaioii?eeo.

Io?eiai? iaie ?acoeueoaoe na?ae/aoue i?i oa, ui aeei?enoaiiy
eaioii?eeiai? i?iae c iaeii?aciaei i?eeiiii 25ia i?aia?aoo, aeicaiey?
aaeaeaaoii ioe?ieoe noai aeiia?oey?ii? aaiiaeeiai?ee, ?? ?aaeoeai?noue
ia ??cieo noaae?yo AeI. Iaeiae aiia iaaeinoaoiuei /ooeeaa aeey
aeeoa?aioe?aoe?? AeI II ? III noaae?e. A oie aea /an eaioii?eeiaa i?iaa
?ioi?iaoeaia o oai?eo ia aeiee?i?/ieo noaae?yo AeI o ieai? i?iaiicoaaiiy
?? iiceoeaiiai aieeao ia ia?oe?aeuei? ooieoe?? ie?ie, cie?aia OIEO, ?
a?aeai?o oai?eo aeey e?eoaaiiy eaioii?eeii.

Aieea iaaeeeaiaioicii? i?iae c ?iaeiiaoaoeeiii ia oaeaee?noue
eeoai/eiai? o?eueo?aoe??

I?e i?iaaaeaii? iaaeeeaiaioicii? i?iae c ?iaeiiaoaoeeiii iaie
a?aei?/aii, ui o a?oi? iaoe??io?a aac AeI aaaaeaiiy i?aia?aoo
i?enei?thaaei OEO, yea, iaeiae caeeoaeanue o iaaeao ii?iaeueieo aaee/ei
– 80 ± 2,3 ie/oa ? 103 ± 2,2 ie/oa (P

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