Oe?a?inueea aeaaeai?y aa?a?ieo iaoe

?inoeooo aenia?eiaioaeueii? ? ee?i?/ii? aaoa?eia?ii? iaaeeoeeie

Ne?eiea Ia?eia A?eoi??aia

636.5:619:616.98:578.

Inaaaeiiiiic ioeoe? a Oe?a?i?

oa a?ieia?/i? aeanoeaino? caoaeieea

16.00.03 — aaoa?eia?ia i?e?ia?ieia?y oa a??onieia?y.

Aaoi?aoa?ao

ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa

aaoa?eia?ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? a??onieia??, iaoaiaoii?? oa oai?ia
ioeoe? Noinueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo

Iaoeiaee ea??aiee: eaiaeeaeao aaoa?eia?ieo iaoe, aeioeaio Cii A.A.,

aeioeaio eaoaae?e a??onieia??,
iaoaiaoii?? ? oai?ia

ioeoe? Noinueeiai aea?aeaaiiai
oi?aa?neoaoo

Io?oe?ei? iiiiaioe: aeieoi? aaoa?eia?ieo iaoe, i?ioani?, /eai-

ei?aniiiaeaio OAAI Aa?iai A.A.,
caa?aeoaa/

eaai?aoi??? oai?ia ioeoe? ?inoeoooo
aenia?e-

iaioaeueii? ? ee?i?/ii?
aaoa?eia?ii? iaaeeoeeie

OAAI

eaiaeeaeao aaoa?eia?ieo iaoe ?aaa
I.I.,

noa?oee aeeeaaea/ eaoaae?e
iaoaiaoii?? ?

iaoo?c?ieia?? Oa?e?anueeiai
ciiaaoa?eia?iiai

?inoeoooo

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee aa?a?iee oi?aa?neoao, eaoaae?a

i?e?ia?ieia?? ? a??onieia??,
Eaa?iaoo I?i?no??a

Oe?a?ie, i.Ee?a

Caoeno a?aeaoaeaoueny 22 /a?aiy 1999 ?ieo ia can?aeaii?
niaoe?ae?ciaaiii? a/aii? ?aaee

Ae 64.359.01 i?e ?inoeooo? aenia?eiaioaeueii? ? ee?i?/ii? aaoa?eia?ii?
iaaeeoeeie OAAI: 310023, i.Oa?e?a, aoe. Iooe?inueea, 83

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooooo
aenia?eiaioaeueii? ? ee?i?/ii? iaaeeoeeie OAAI (310023, i.Oa?e?a, aoe
Iooe?inueea, 83)

Aaoi?aoa?ao ?ic?neaiee 21 o?aaiy 1999 ?ieo

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? aaoa?eia?ieo iaoe,

i?ioani?
Eiia?aeaanueeee E.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?icaeoeo ioao?aieoeoaa caaaaeathoue oai?iae ??cii?
ao?ieia??. A iaoieia?? ioeoe? ieoiia aaaa oiiaii iaoiaaiieo aaeoa??e,
cie?aia neiueiai?eii? iaee/ee, a inoaii? ?iee noaea ca?eueooaaoenue ia
oii? ?ioeo caoaeiee?a oai?ia aaeoa??aeueii? i?e?iaee.

Caoaeiee neiueiai?eii? ?ioaeoe?? ? i?aaenoaaieeii iaeiiai ?c iaaaaaoueio
aeae?a aaeoa??e, ui ? iaoiaaiieie ye aeey ethaeeie, oae ? aeey oaa?ei.
Iaea?eueoa e?euee?noue iia?aeiieaiue i?i caoai?thaaiiy ia inaaaeiiiiic
nnaaoe?a.

Inaaaeiiiiic iioe?aiee o anueiio na?o?. Cia/ia /anoeia iia?aeiieaiue
i?enay/aia inaaaeiiiiici?e ?ioaeoe?? o ethaeae, a ?c oaa?ei — o aaeeei?
?iaaoi? ooaeiae. ? ?ioi?iaoe?y ? i?i inaaaeiiiiic ioeoe? ?c ??cieo e?a?i
na?oo [Ii?icia A.O., 1988; Aiaeoi A.O., Ai?enaieiaa A.E., 1989;
*a/aoeeia I.I., *a/aoeeia E.A., 1995; Eanne/ A.TH., Aieinyiei A.A.,
1995; Ooen I.I., c ni?aaao., 1997; Matthens S., 1989; Ramassatry P. et
al., 1991].

A e?oa?aoo?? ? ?yae iia?aeiieaiue i?i aeae?eaiiy P.aeruginosa a?ae
aia??ii?a, ?c oea?aeoie ? ioeoe? ?yaeo eo?y/eo oa iiiaeeiie?
iia?aeiieaiiy i?i ?cieyoe?th aaeoa??? a?ae ?ioi? ioeoe?. Oae,
?.aeruginosa aoea oaeiae ?cieueiaaia a?ae aiaeiieaaii? ioeoe?, iaioa,
oacai?a, aieoa?a [?ueiaa A.N., Ee?aaa I.A., 1989; Oa?iiei N.A., 1993;
Shirakawa H et al., 1990].A e?oa?aoo?? ? iaeia iia?aeiieaiiy i?i
?cieyoe?th ?.aeruginosa a?ae 19-oeaeiaiaeo ia?aiae?a [Zhang Dao Yong et
al., 1995]. Caoaeieea inaaaeiiiiico /ano?oa aeae?eythoue ?c eaaaiue,
noaeia?a, ??aeoa c ia/?iee, na?oey, e?noeiaiai iiceo eo?/ao, a oaeiae ?c
ae?eyiie caiaeaiiy a i?aeoe??i?e ee?oeiaei?. Iia?aeiieaiue i?i
inaaaeiiiiic ioeoe? a ainiiaea?noaao Oe?a?ie a iaoeia?e e?oa?aoo?? ie ia
ciaeoee. Iia?aeiieaiiy i?i inaaaeiiiiic ioeoe? ia nenoaiaoeciaai? ? ia
aeathoue a iiai?e i??? oyaeaiiy i?i cia/aiiy P.aeruginosa a iaoieia??
n.-a. ioeoe? a Oe?a?i?. Iaaeinoaoiuei aea/ai? iniaeeaino? ai?ciioieia??
oai?iae oa ee?i?ei-iaoiii?oieia?/i? iciaee o ??cieo aeae?a
n?euenueeiainiiaea?nueei? ioeoe?, oa cie?aia o ia?aiae?a, a?ieia?/i?
aeanoeaino? inaaaeiiiiaae, ye? ?cieueiaai? c ??cieo aeaea?ae.

Neiueiai?eia iaee/ea, ye iaoeiaee ia’?eo, ye ? neiueiai?eia ?ioaeoe?y,
iiaeooue aooe a?aeianai? aei iaei??? ?c aaaeeeaeo i?iaeai ye
aaoa?eia?ii?, oae ? iaaee/ii? iaoee.

Aeooaeuei?noue ia?a?aoiaaieo ieoaiue oa ia?niaeoeaa ?icaeoeo
ioao?aieoeoaa, cie?aia ia?aiae?aieoeoaa, a no/aniee ia??iae iaoiiaeee
iai?yiee iaoeiaeo aeine?aeaeaiue ? oaio aeena?oaoe?eii? ?iaooe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa ? /anoeiith AeAO eaoaae?e a??onieia??, iaoaiaoii?? ? oai?ia
ioeoe? Noinueeiai AeAO, (? aea?ae. ?a?no?aoe?? 0198 U001290).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith aeine?aeaeaiue aoei aea/aiiy
a?ieia?/ieo aeanoeainoae caoaeieea inaaaeiiiiico, ?cieueiaaiiai a?ae
n?euenueeiainiiaea?nueei? ioeoe? oa eiai ?iciianthaeaeaiiy a
ioaoiainiiaea?noaao Oe?a?ie.

Aeey aeinyaiaiiy iinoaaeaii? iaoe aoee aecia/ai? oae? caaaeaiiy:

-aea/eoe ?iciianthaeaeaiiy inaaaeiiiiico na?aae
n?euenueeiainiiaea?nueei? ioeoe? a Oe?a?i?; aea/eoe a?ieia?/i?
aeanoeaino? eiai caoaeieea, ?ieue a iaoieia?? ioeoe? a aenia?eiaio? oa
i?e ?? i?iieneiaiio oo?eiaii?;

-i?iaanoe ii??aiyeueio ioe?ieo aeanoeainoae ai?ciioe/ieo eoeueoo?
P.aeruginosa, ?cieueiaaieo a?ae aia??ii?a oa oai?i? ioeoe?;

-?ic?iaeoe aeni?an-iaoiae ae?aaiinoeee, ?cieyoe?? oa ?aeaioeo?eaoe??
caoaeieea inaaaeiiiiico;

-anoaiiaeoe niaeo? /ooeeaino? P.aeruginosa aei aioeaaeoa??aeueieo
i?aia?ao?a oa ?ic?iaeoe caoiaee ii i?io?eaeoeoe? oeueiai caoai?thaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. A ?iaio? aia?oa iaaaaeai?
aeai? ii iayaiino? inaaaeiiiiico o ??cieo aeae?a ioeoe? oa aia??ii?a a
ainiiaea?noaao a?eueoino? iaeanoae Oe?a?ie. Aenia?eiaioaeueii aeiaaaeaia
iiaeeea?noue ca?aaeaiiy ia?aiae?a ?.aeruginosa.

Ia i?aenoaa? aeine?aeaeaiue ai?ciioe/ieo eoeueoo? caoaeieea
inaaaeiiiiico aeiaaaeaia ?aeaioe/i?noue iniiaieo a?ieia?/ieo
aeanoeainoae o a?eueoino? ?cieyo?a neiueiai?eii? iaee/ee, ui ?cieueiaai?
a ??cieo ?aa?iiao Oe?a?ie.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aea/aii niaeo? /ooeeaino?
aei aioeaaeoa??aeueieo i?aia?ao?a ??cieo ai?ciioe/ieo eoeueoo?
P.aeruginosa, ye? ?cieueiaai? a?ae ioeoe? oa aeiaaaeaia iaeaeoeai?oa
ae?y ai?ioeienaoeeio (aaeo?eeo) oa aaioai?oeeio i?e e?eoaaii?
?io?eiaaii? caoaeieeii inaaaeiiiiico ioeoe?.

Ia i?aenoaa? aea/aiiy aeanoeainoae caoaeieea ?ic?iaeaii iiaa iiaeeaia
na?aaeiaeua aeey eoeueoeaoaaiiy P.aeruginosa. Cai?iiiiiaaia iiaa noaia
aeae?eaiiy ? aeeoa?aioe?aoe?? caoaeieea inaaaeiiiiico, ui
a?ae??ciy?oueny canoinoaaiiyi iaioi? e?eueeino? na?aaeiaeu, oa
nei?i/aiiyi /ano i?iaaaeaiiy eaai?aoi?ieo aeine?aeaeaiue.

?ic?iaeai? a ni?aaaoi?noa? ? cai?iiiiiaai? aeey ae?iaieoeoaa “Iaoiaee/i?
aeac?aee ii ae?aaiinoeoe? ? i?io?eaeoeoe? inaaaeiiiiico
n?euenueeiainiiaea?nueei? ioeoe?”.

Iniiai? ?acoeueoaoe aeine?aeaeaiue ii aea/aiith a?ieia?/ieo aeanoeainoae
caoaeieea, oa eiai ?iciianthaeaeaiiy ia Oe?a?i? aeei?enoiaothoueny a
iaa/aeueiiio i?ioean? i?e aeeeaaeaii? eo?n?a c i?e?ia?ieia??,
ai?ciioieia?? oa oai?ia ioeoe? ia oaeoeueoao? aaoa?eia?ii? iaaeeoeeie
Noinueeiai AeAO.

Iniaenoee aianie caeiaoaa/a. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue
iieacaii ??aaiue iioe?aiiy inaaaeiiiiico na?aae n.-a. ioeoe? a ie?aieo
iaeanoyo Oe?a?ie. Anoaiiaeai? iaoieiaiaiaoii?/i? ci?ie i?e o?aaeaii?
neiueiai?eiith iaee/eith aia??ii?a ? iieiaeiyea ioeoe? a i?e?iaeieo
oiiaao oa a aenia?eiaio? o eo?/ao ? ia?aiae?a.

C’yniaaii niaeo? /ooeeaino? ?.aeruginosa aei aioeaaeoa??aeueieo
i?aia?ao?a a ioaoiainiiaea?noaao a?eueoino? iaeanoae Oe?a?ie.

Iniaenoee aianie iieyaa? a naiino?eiiio aeeiiaii? aeine?aeaeaiue oa
aenia?eiaioaeueii? ?iaioe, aiae?co io?eiaieo aeaieo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
ai?iaiaai? oa noaaeai? ia:

-ia?o?e iaoeia?e eiioa?aioe?? ii ioao?aieoeoao (Ai?ee-N?ioa?iiieue,
1993);

-iaoeia?e eiioa?aioe?? “Iai?yiee i?aeaeuaiiy i?iaeoeoeaiino? oa yeino?
n?euenueeiainiiaea?nueei? ioeoe?” (Noie, 1995);

-ae?oa?e iaoeia?e eiioa?aioe?? ii ioao?aieoeoao (Ai?ee, 1996);

— ia ui??/ieo ca?oieo iaoeiaeo eiioa?aioe?yo Noinueeiai AeAO
(1993-1999).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o, c ieo o?e
o oaoiaeo aeaeaiiyo (aeo?iaee Aaoa?eia?ia iaaeeoeeia Oe?a?ie,
Oaa?eiieoeoai Oe?a?ie oa A?nieeo NAeAO), i’youe o iaoa??aeao
eiioa?aioe?e.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 130
noi??ieao eiii’thoa?iiai oaenoo ? i?noeoue 30 oaaeeoeue, 4 iaethie?a;
ia? caaaeueio oa?aeoa?enoeeo ?iaioe, iaeyae e?oa?aoo?e, iniaeno?
aeine?aeaeaiiy, iaaiai?aiiy, aeniiaee, nienie e?oa?aoo?e, 4 aeiaeaoe?a.
Ia?ae?e e?oa?aoo?e aeeth/a? 187 aeaea?ae, c ieo 105 ?iicaiieo.

?ACOEUeOAOE AeINE?AeAEAIUe

Iaoa??aee ? iaoiaee. Aeine?aeaeaiiy i?iaiaeeeenue ia eaoaae??
a??onieia??, iaoaiaoii?? oa oai?ia ioeoe? Noinueeiai aea?aeaaiiai
aa?a?iiai oi?aa?neoaoo ia iaoa??aeao, ui iaea?aeai? c ioaoiainiiaea?noa
??cieo iaeanoae Oe?a?ie.

I?e aea/aii? ai?ciioe/ii? neooaoe?? uiaei inaaaeiiiiico ioeoe?
aeei?enoiaoaaee iaoiae ai?ciioe/iiai ianoaaeaiiy ? aenia?eiaioo
(E.A.Aaeoeia c niaao., 1982).

Anueiai iaie aoei aeine?aeaeaii a aenia?eiaio? 540 eo?y/eo, 115 ea/eieo
oa 71 aony/eo aia?iii?a-caaeioeee?a; o?oi?a oa aeeaeo eo?/ao aeiaiaiai
a?eo – 288, aei?ineeo eo?ae – 36, ia?aiaeaiyo – 216, ieoae – 96.

Aaeoa??ieia?/ia aeine?aeaeaiiy: aea/aiiy ii?oieia?/ieo, o?ieoi??aeueieo
? eoeueoo?aeueii-a?io?i?/ieo aeanoeainoae aeae?ea-ieo eoeueoo?
i?iaiaeeee ca caaaeueiii?eeiyoeie iaoiaeeeaie (Ni?aai/iee aaoa?eia?iiai
eaai?aioa I., Eiein 1981; Eaai?a-oi?iua enneaaeiaaiey a aaoa?eia?ee, I.,
Aa?ii?iiecaeao, 1986: Ni?aai/iee niaoeeaeenoa aaoa?eia?iie eaai?aoi?ee,
E., O?iaeae. 1987).

I?e i?iaaaeaii? aaeoa??ieia?/ieo aeine?aeaeaiue aoee aeei?enoai? oae?
na?aaeiaeua: IIA, IIA, OOeA, Aiaei, E?iaa A, E?iaa A, na?aaeiaeua c
na/iaeiith, a?a?i?iii, aoeaoai?aeiee aaa?, e?ia’yiee aaa?, na?aaeiaeua
N?iiiina, Eea?ea, IIAE oa na?aaeiaeua A?nna c aetheicith ? aaeaeoicith.

Iaie aoei aea/aii 3 noaie aeae?eaiiy oa ?aeaioeo?eaoe?? neiueiai?eii?
iaee/ee ? i?iaaaeaia ?o ii??aiyeueia ioe?iea.

Ca noaiith 1 a?ae?a?aiee iaoa??ae, can?aaee ia iiaeeai? na?aaeiaeua: c
OeIO, aaa? Aiaei, IIA, IIA, E?iaa A, na?aaeiaeua c aeaeaoeiith,
a?a?i?iii, aoeaoai?aeiee aaa?, eaeioniaa iieiei.

Ca?aeii ?c noaiith 2 i?iaiaeeee aen?ae iaoa??aeo, ui aeine?aeaeo?oueny
ia oae? na?aaeiaeua: 5%-e e?ia’yiee aaa?, aaa? Aiaei, 1,5%-e IIA, aaa?
OeIO, IIA, aoeueeii Oioo?iaa?a, na?aaeiaeua E?iaa A, A?nna c aetheicith.

Ca?aeii c? noaiith 3 aeae?eaiiy oa ?aeaioeo?eaoe?th eoeueoo? i?iaiaeeee
ca oaeeie iciaeaie ye ??no ia IIA ? IIA, oa?aeoa? aaiie?co, iniaeeaino?
?inoo ia OOeA c na/iaeiith, ia na?aaeiaeu? Eea?ea, N?iiiina, A?nna,
IIAE, cai?oaiiy iieiea.

Na?ieia?/ia oeioaaiiy aeae?eaieo eoeueoo? i?iaiaeeee a?aeiia?aeii c
“A?aiaiiui ianoaaeaieai ii i?eiaiaieth iaai?a I-aaaethoeie?othueo
nuai?ioie aeey aeeaaiinoeee inaaaeiiiiica” ca aeiiiiiaith iaai?o
aaethoeioth/eo I-ne?iaaoie inaaaeiiiiaae, aei neeaaeo yeiai aoiaeyoue
o?e iie?aaeaioieo oa 11 iiiiaaeaioieo ne?iaaoie P.aeruginosa: I2, I3,
I4, I5, I6, I7, I8, I9, I10, I11, I12.

*ooeea?noue aeae?eaieo eoeueoo? aei aioeaaeoa??aeueieo i?aia?ao?a
aecia/aee iaoiaeii aeene?a c aioea?ioeeaie oa iaoiaeii na??eieo
?icaaaeaiue a ??aeeiio iiaeeaiiio na?aaeiaeu?.

Aeey aea/aiiy iaoiaaiiino? aeae?eaieo eoeueoo? P.aeruginosa aeey
aia??ii?a ? ioeoe? ?io?eoaaee aeaiia iaoiaeaie aia??iie oa
anoaiiaethaaee LD50 aeey 30-aeaiieo eo?/ao, ia?aiaeaiyo oa ieoae ca
iaoiaeii ??aea ? Iai/a.

Coaoenoe/io ia?iaeo iaea?aeaieo aeaieo i?iaiaeeee ii iaoiaeo
A.A.Aineiaieieeiaa (1993) ? ii iaoiaeo ??aea ? Iai/a, oa ca aeiiiiiaith
eiii’thoa?a.

Aea/aiiy ?iciianthaeaeaiiy inaaaeiiiiico ia ioaoii?aei?e?inoaao Oe?a?ie.
Aea/aiiy ai?ciioe/ii? neooaoe?? i?iaiaeeee oeyoii iciaeiieaiiy c aeaieie
ca?o?a aea?aeaaieo onoaiia ? eaai?aoi??e aaoa?eia?ii? iaaeeoeeie
(iaeanieo oa ?aeiiieo) oa ioaoiainiiaea?noa, a oaeiae aeei?enoiaoaaee
iaoa??aee aeanieo aeine?aeaeaiue ca ia??iae c 1994 ii 1998 ?iee.

Neeaaeiaith /anoeiith aea/aiiy ai?ciioe/ii? neooaoe?? aoa aiae?c
?iciianthaeaeaiiy caoaeieea neiueiai?eii? ?ioaeoe?? oa eiai iayai?noue a
aia??iiao-caaeioeeeao oa iieiaeiyea ioeoe? ia?oeo aei?a aeeooy.

?cieyoe?y neiueiai?eii? iaee/ee ?c ??cieo aeaea?ae a caeaaeiino? a?ae
ia??iaeo ?ieo ?ethno?iaaii a?ao?eii (?en.1).

Caeaaei?noue aeiaaee?a ?cieyoe?? neiueiai?eii? iaee/ee a?ae aia??ii?a,
iieiaeiyea oa aei?inei? ioeoe? a?ae ia??iaeo ?ieo

?en.1
i?nyoe?

Aiae?coth/e aeai? a?ao?ea 1, iiaeia neacaoe, ui o?aaeaiiy aia??ii?a oa
eo?/ao ia?oeo aei?a aeeooy iae/ano?oa niinoa??aa?oueny c a?oaeiy ii
/a?aaiue, ui ie iia’yco?ii c aeoeaiith ae?yeuei?noth ioaoioaa?ee,
?ieoaaoe??th oa ae?iuoaaiiyi iieiaeiyea a oeae ia??iae.

Noiniaii caaeaae? iieiaeiyea aei 2-i?ny/iiai a?eo, oi ie niinoa??aaee
eiai o oeae aea oa?i?i, a caaeaaeue aai o?aaeaiiy aei?inei? ioeoe?,
niinoa??aaee eiaeiee i?nyoeue ?ieo. Inoaii? iia’yco?ii c ?cieyoe??th
P.aeruginosa i?e aeine?aeaeaii? iaoieia?/iiai iaoa??aeo, yeee
iai?aaeythoue aei eaai?aoi??? a ca’yceo c i?aeaeuaiith caaeaaeeth
a?aeiia?aeii? a?oie ioeoe?.

Oaaeeoey 1

?acoeueoaoe ?cieyoe?? eoeueoo? P.aeruginosa a?ae aia??ii?a ? ioeoe? a
??cieo iaeanoyo Oe?a?ie

Iaeanoue

? ? e A i a ? ? i i e E o ? / a o a E o ? e ? i ae e / a i y o a ? i ae
e e e E a / a i y o a A o n e ae i a i a ? O a c a i e A n ue i a i

E o ? y / ? ? i ae e / a / ? A o n y / ? E a / e i ? 1 — 5 ae ? a 5 – 4
0 ae ? a 40 –120 ae ? a

A?iieoeueea 19941998 6 — — — 3 19 37 — — — — — — 65

Ee?anueea 19941997 31 3 — — 42 57 4 19 15 4 — — — 175

Euea?anueea 19941995 3 — — 3 — 10 8 12 — — — — — 36

Noinueea 19941997 20 — — 3 8 7 1 1 — — — — — 40

A.?

E?ei 19951997 2 — — — 13 5 3 1 — — 1 — 15 40

Oa?e?anueea 19941996 2 — 2 — 7 — — — — — — 1 — 12

Aeiiaoeueea 19941995 — — — 4 — — — — — — — — — 4

AEeoiie?-nueea 19961998 — — — — 9 1 — — — — — — — 10

Caii??aecue-ea 19941998 — — — — 17 15 5 8 — — 2 — — 47

Eoaainueea 19951996 — — 2 — 2 4 — 3 — — — 1 — 12

Iieoaanueea 19941995 — — 10 — — — — — — — — — — 10

*a?eanueea 19941995 — — — — — 4 3 — — — — — — 7

*a?i?a?anue-ea 1994 — — — — — — — — 2 — — — — 2

Anueiai

64 3 14 10 101 122 61 44 17 4 3 2 15 460

Inaaaeiiiiic na?aae aia??ii?a ioeoe? iaa i?noea a ainiiaea?noaao an?o
ianoaaeaieo iaie iaeanoae ? A.?. E?ei, oi/ a a?eueoino? aeiaaee?a
io?oe?eii ia ?a?no?oaaany.

I?e oeueiio eoeueoo?e ?.aeruginosa aoee ?cieueiaai? a?ae aei?ineeo
eo?ae, eo?/ao, ea/aiyo, aonaiyo, ?iaee/aiyo oa oacaiyo ? c eo?y/eo,
ea/eieo oa aony/eo aia??ii?a.Aeai? iaaaaeaii a oaaeeoe? 1.

Neiueiai?eia iaee/ea aeae?eyeanue oaeiae ?c aaaaoueio i?ia eiia?ei?i?a,
ui aeei?enoiaothoueny a ioaoiainiiaea?noaao, i?i ui na?ae/aoue aeai?
oaaeeoe? 2.

Oaaeeoey 2

Aeae?eaiiy eoeueoo? neiueiai?eii? iaee/ee ?c c?ace?a ei?i?a

ca aeaieie iaeanieo eaai?aoi??e aaoa?eia?ii? iaaeeoeeie

Iaeanoue, c yei? iinooiea c?acie E?euee?noue

c?ace?a E?euee?noue

eoeueoo?

Ee?anueea 44 24

*a?i?aaoeueea 8 4

AEeoiie?nueea 7 7

Eoaainueea 4 4

*a?eanueea 2 1

Eiioai?iiaai? P.aeruginosa eiia?ei?ie a?ae?a?athoue iaaio ?ieue a
?iciianthaeaeaii? inaaaeiiiiico ioeoe?.

?cieyoe?y P.aeruginosa ? ?ic?iaea aeni?an-iaoiaea ?aeaioeo?eaoe??.

Aeae?eaiiy caoaeieea oai?iae. Ca ia??iae aeine?aeaeaiiy (1994-1997)
iniaenoi iaie ?cieueiaaii ? aeine?aeaeaii 44 eoeueoo?e, c ieo a?n?i
eoeueoo? a?ae eo?y/eo aia??ii?a, iaeiiai ea/eiiai aia??iio, oanoe eo?/ao
aeiaiaiai a?eo c Noinueei? iaeano?; aeanyoue eoeueoo? a?ae aony/eo
aia??ii?a Iieoaanueei? iaeano?; ii aea? eoeueoo?e a?ae eo?y/eo aia??ii?a
oa eo?/ao Oa?e?anueei? iaeano?; o?e eoeueoo?e a?ae eo?ae Ee?anueei?
iaeano?; o?e eoeueoo?e a?ae ea/eieo aia??ii?a c ioaoiainiiaea?noa
Aeiiaoeueei? iaeano?.

Noaia aeae?eaiiy oa ?aeaioeo?eaoe?? neiueiai?eii? iaee/ee

Aeine?aeaeoaaiee iaoa??ae

Aen?a ia aenia?eiaioaeueia

Na?aaeiaeua oa ?ieoaaoe?y i?e 41i N

Aen?a ia aenia?eiaioaeueia

Na?aaeiaeua oa ?ieoaaoe?y i?e 5i N

I?e aaeoa??ineii?? a?aiiaaaoeai? iaee/ee

Oeeoio?iiieneaeaciee oano

?icaeeaeaiiy aeaeaoeie

?aeaioeo?eaoe?y P.aeruginosa

?en. 2

Oaeiae io?eiaii /ioe?e ?cieyoe neiueiai?eii? iaee/ee c? ciea?a c
iaeaaeiaiiy ioaoiainiiaea?noa Noinueei? oa Aeiiaoeueei? iaeanoae. C
c?ace?a iia?o?y eoeueoo?a P.aeruginosa aoea aeae?eaia a aeaio aeiaaeeao
a ioaoiainiiaea?noaao Noinueei? iaeano?, a ?c c?ace?a aiaee — a o?ueio
aeiaaeeao a ioaoiainiiaea?noaao Aeiiaoeueei? iaeano?.

Aea/aiiy a?ieia?/ieo aeanoeainoae ai?ciioe/ieo ?cieyo?a ?.aeruginosa. A
90% aeiaaee?a eoeueoo?e P.aeruginosa aoee ?ooeeaeie, a?aiiaaaoeaieie
iaee/eaie. Caeaoi?noue aei ooai?aiiy i?ioe?ai?io iaee 80% eoeueoo?. An?
aeine?aeaeai? eoeueoo?e – aa?iae, 80% eoeueoo? oa?iaiooaaee aetheico,
aaeaeoico c ooai?aiiyi eeneioe aac aaco. Iiceoeai?noue
oeeoio?iiieneaeaciiai oanoo neeaea 100%. Aeae?eai? eoeueoo?e a 100%
aeiaaee?a ia ooai?thaaee ?iaeieo oa aoeaoeeiaoeeea?a?iieo.

?icaeeaeaiiy aeaeaoeie a?aeaoaaeinue o aeaeyae? ai?iiee, a aeae?
iioa?iai a 100% aeiaaee?a. Ooai?aiiy eaoaeace niinoa??aaee a 84%.
Aaiie?oe/i? aeanoeaino? anoaiiaeaii o 90% aeae?eaieo eoeueoo?.

I?e ?ino? ia e?ia’yiiio aaa?? o oeeo eoeueoo? a?aei?/aee /?oeee oaiiiai
“?aeaeoaeiiai e?ceno”. Iaeiae, i?e ia?an?aaii? oa caa??aaii? eoeueoo?
iiiaae i?nyoeue aaiie?oe/i? aeanoeaino? ?? neaaoaee. Oae, 30% c ieo
cian?i ao?a/aee aaiie?oe/i? aeanoeaino?, 50% — /anoeiai ? o?eueee 20% ?o
caa??aaee.

Caeaoi?noue cn?aeaiiy iieiea niinoa??aaeanue o 96% eoeueoo?. 93,1%
eoeueoo? P.aeruginosa i?e ?icuaiethaaii? na/iaeie caaa?aethaaee
na?aaeiaeua o /a?aiiee eie??.

Aeine?aee iieacaee, ui an? aeae?eai? eoeueoo?e ca nai?ie a?io?i?/ieie
aeanoeainoyie ca?aathoueny c iniiaieie aeanoeainoyie iocaeiiai ooaio.

Ia ii/aoeo aeine?aeaeaiue aeey aeae?eaiiy ? ?aeaioeo?eaoe?? P.aeruginosa
ie aeei?enoiaoaaee aeua caaaeai? noaie 1, 2 ? 3. Iaeiae aeei?enoaiiy
oeeo noai aeiaaa? iayaiino? aaeeei? e?eueeino? iiaeeaieo na?aaeiaeu oa
aeo?ao /ano. Oae, ca noaiith ?1 oa?i?i noaiiaeoue 5-6 ae?a oa
aeei?enoiaothoue 11 na?aaeiaeu, ca noaiith ? 2 – 3 aei?, 10 na?aaeiaeu,
ca noaiith ?3 – 3 aei?, 9 na?aaeiaeu.

Iaei??th c caaea/ iaoeo aeine?aeaeaiue aoea ni?iaa cai?iiiioaaoe noaio
?aeaioeo?eaoe?? neiueiai?eii? iaee/ee, yea a aeiaaaea yeiaeiaioeo aeo?ao
/ano, a oaeiae aeei?enoaiiy na?aaeiaeu eaaeiaeinooiieo a oiiaao ia
o?eueee iaoeiai-aeine?aeieo caeeaae?a, aea e aeey ?iaioe ae?iaie/eo
eaai?aoi??e aaoa?eia?ii? iaaeeoeeie.

Iaie aoei ?ic?iaeaii iiaeeaia na?aaeiaeua, yea a?eueia a?ae ?ia?aoth/eo
?a/iaei, c o?aooaaiiyi, ui P.aeruginosa aeia?a ?inoa a na?aaeiaeu?, yea
i?noeoue iaaiee a?aenioie ai?aeo ye aeaea?aea acioo ? aeoeaii
aeei?enoiao? aetheico a yeino? aeaea?aea aoaeaoeth. Eoeueoeaoaaiiy ia
cai?iiiiiaaiiio na?aaeiaeu? neiueiai?eii? iaee/ee aeoea?co? ooai?aiiy
i?aiaio?a i?ioe?ai?io oa i?i?oa?io, ui ? aeeoa?aioe?thth/ith iciaeith
P.aeruginosa a?ae ?ioeo aeae?a ?iaeo Pseudomonas. Ia aenia?eiaioaeueiiio
na?aaeiaeu? 93% eieii?e aoee i?aiaioiaai?, a ia na?aaeiaeu? E?iaa A –
85%, a a 15% cono??/aeenue iai?aiaioiaai? eieii??.

I?iaaaeaiiyi ii??aiyeueieo aeine?ae?a ii eoeueoeaoaaiith caoaeieea
inaaaeiiiiico ia caaaeueiii?eeiyoeo oa aenia?eiaioaeueiiio na?aaeiaeuao,
aoei anoaiiaeaii, ui aenia?eiaioaeueia na?aaeiaeua ia? aenie? naeaeoeai?
oa ?inoia? aeanoeaino?, i?eaeaoia aeey aeae?eaiiy P.aeruginosa c
ia?aeiiiai iaoa??aeo.

Iaie aoea cai?iiiiiaaia aeey iiaeaeueoi? ?iaioe noaia 4, aeae?eaiiy oa
?aeaioeo?eaoe?? neiueiai?eii? iaee/ee c canoinoaaiiyi
aenia?eiaioaeueiiai na?aaeiaeua, ca yeith iine?aeiaii aeei?enoiaothoue
o?e i?inoeo na?aaeiaeua oa aeo?a/a?oueny aeaa aei? (?en.2.).

C aeae?eaieo 44 ai?ciioe/ieo eoeueoo? P.aeruginosa ii Noinuee?e iaeano?
36,8% iaeaaeaee aei na?iaa??aioo I8, 21,5% — I2, 21,05% — I4 oa 10,53%
aei I6; 10,53% — ia oeioaaeenue.A Iieoaanuee?e iaeano? 30% eoeueoo?
iaeaaeaee aei na?iaa??aioo I8, 50% — I5, a 20% ia oeioaaeenue. A
Aeiiaoeuee?e iaeano? 50% aeae?eaieo eoeueoo? aoee a?aeianai? aei
na?iaa??aio?a I5, 12,5% — I4, 37,5%- I2. C /ioe?ueio eoeueoo? aeae?eaieo
o Oa?e?anuee?e iaeano? o?e eoeueoo?e iaeaaeaee aei na?iaa??aioo I5,
iaeia eoeueoo?a – aei I2. C o?ueio eoeueoo? ?cieueiaaieo a Ee?anuee?e
iaeano?, aea? eoeueoo?e iaeaaeaee aei na?iaa??aio?a I8, iaeia eoeueoo?a
aei I5. Oe? aeai? na?ae/aoue, ui ia?aaaaeia a?eueo?noue io?eiaieo
?cieyo?a a?aeiineeanue aei na?iaa??aio?a I2, I5 oa I8.

Aea/aiiy iaoiaaiieo aeanoeainoae eoeueoo? P.aeruginosa aeey aia??ii?a ?
ioeoe?. Iaie aoea aea/aia iaoiaaii?noue ?cieyoa E/a N4 na?ioeio I8
P.aeruginosa aeey eo?y/eo aia??ii?a i?e aeaio iaoiaeao ?io?eoaaiiy. Oae,
?io?eoaaiiy a aeiaoeiaee i?oo? 6-aeiaiaeo oa ia OAI 11-aeiaiaeo eo?y/eo
aia??ii?a ni?e/eiyei ?o caaeaaeue, iacaeaaeii a?ae aeice ?io?eoth/iai
iaoa??aeo.

I?e aea/aii? iaoiaaiiino? P.aeruginosa aeey 10-aeiaiai? ioeoe? ?yaeo
eo?y/eo (eo?/aoa oa ia?aiaeaiyoa) anoaiiaeaii, ui aenie? eiioeaio?aoe??
caoaeieea i?e ia?aioa?aeueiiio iaoiae? ?io?eoaaiiy i?ecaiaeyoue aei
caaeaae? 100% i?aeaeine?aeii? ioeoe?, a i?e eiioeaio?aoe?? caoaeieea
32,5 oen.i.o./ie ?io?eoth/iai iaoa??aeo ye eo?/aoa, oae ? ia?aiaeaiyoa
caeaoi? aeaeeaaoe. LD50 noa-iiaeei aeey eo?/ao 81 oen.i.o., a aeey
ia?aiaeaiyo – 170 oen.i.o.

Neiioiie ? iaoieiaiaiaoii?/i? ci?ie i?e inaaaeiiiiic? o ??cieo aeae?a
ioeoe? oa eaai?aoi?ieo oaa?ei. Iae/ooeea?oeie aei ca?aaeaiiy
inaaaeiiiiicii aeyaeeenue aia??iie oa eo?/aoa ia?oeo aei?a aeeooy.

I?e oeueiio caaeaaeue o eo?y/eo aia??ii?a o ae?iaie/eo oiiaao /anoi
ianoa? ia 17-18 aeiao ?ieoaaoe??. *ano? aeiaaeee, eiee aia??ii, ui
ineaaeaiee iaoiaaiiith i?e?ioei?ith, ia caeaoiee ceaiaoe oea?aeoio ?
aeia ia aeaiae?.

I?e iaoieiaiaiaoii?/iiio aeine?aeaeaii? aia??ii?a a?aei?/aee yaeua
aaii?aa?/ii? naioeoeai??, o?aaeaiiy eaaaiue, ia/?iee, ie?ie, naeac?iee.
*anoi oe? i?aaie iathoue ae?yaeo eiinenoaioe?th, oaiii-ei?e/iaaee eie??.

Iieiaeiye, ui o?aaeaiee P.aeruginosa, ia?iaeaeo?oueny eaieei ?
iaaeeoo?caeaoiei. Aeey ioeoe? ia?oiai oeaeiy aeeooy oa?aeoa?iei ?
caaaeueia i?eai?/aiiy, neoi/aiiy, niinoa??aa?oueny a?aenooi?noue
aiaoeoo, ieya?noue, a ?iiae? aeo?eaiiy ?c aecueiaa. I?e
iaoieiaiaiaoii?/iiio ?icoei? o a?eueoino? aeiaaee?a niinoa??aaee
ia?eoii?o, aioa?ieie?o, aeeno?io?th ia/?iee, iiaaiii?th oa ea?oeio
naineno, caiaeaiiy aa?oi?o aeeoaeueieo oeyo?a.

O iieiaeiyea aeaioeaeiaaiai ? noa?oiai a?eo niinoa??aaee neaae?noue,
niieea?noue, a?aenooi?noue aiaoeoo, a?aenoaaaiiy a ?ino?. Caoai?thaaiiy
ee?i?/ii noi?iaiaeaeoaaeinue yaeuaie, ui i?eoaiaii? oieneeico, aioa?eoo,
ia?eoii?oo.

Aei?inea ioeoey ia?aoai?thaaea aacneiioiiii aai c iciaeaie o?ii?/ii?
iiaaiii?? ? iiooaiiyi noaeia?a e?ioe?aie, cieaeaiiyi iano/ino?. O
aei?ineeo eo?ae i?e ?icoei? iaoea?oeia aoea oa?aeoa?iith aeey
eaoa?aeueii? a?iioiiiaaiii??, oa cano?eii? a?ia?ai?? ia/?iee.

O ieoae, ui caaeioee, ie niinoa??aaee oaeo iaoea?oeio: iiaaiii?y,
e?iaiaeeeae ia na?oe?, caaaeueiee aaiiciee cano?e ia?aio?iaoicieo
i?aai?a, aioa?eoe, ca?eueoaiiy naeac?iee.

*ooeea?noue ?.aeruginosa aei aioeaaeoa??aeueieo i?aia?ao?a. Aea/aiiyi
/ooeeaino? ?cieyo?a P.aeruginosa (aeae?eaieo a?ae aia??ii?a oa ioeoe?) a
??cieo iaeanoyo Oe?a?ie aei aioeaaeoa??aeueieo i?aia?ao?a anoaiiaeaii,
ui a aaaaoueio ?aa?iiao niinoa??aa?oueny ye iiii- oae ?
iie??acenoaioi?noue aei aaaaoueio aioea?ioee?a (?en.3).

Ae?aa?aia /ooeeaino? ?cieyo?a P.aeruginosa

aei aioeaaeoa??aeueieo i?aia?ao?a

?en.3

Iieaciee /ooeeaino? eoeueoo? P.aeruginosa aei ie?aieo aioeaaeoa??aeueieo
i?aia?ao?a cia/ii eieeaaany: a?ae 100% ?acenoaioiino? aei no?aioii?oeeio
a naie aeine?aeaeaieo iaeanoyo aei 41,6 — 57,1% /ooeeaino? a
Oa?e?anuee?e ? Iieoaanuee?e iaeanoyo, 50-71,4% — a AEeoiie?nuee?e,
Euea?anuee?e, Aeiiaoeuee?e iaeanoyo. O aaaaoueio eoeueoo? P.aeruginosa
aei a?eo?ii?oeeio, iiiii?oeeio, eaaii?oeaoeio, aii?oeee?io ii an?o
aeine?aeaeaieo iaeanoyo anoaiiaeaia iecueea /ooeea?noue. Iaeaea
iaeiaeiaee iieaciee (c ??cieoeath 5-10%) aeniei? /ooeeaino? o
aeine?aeaeaieo eoeueoo? aoa aei aaioai?oeeio oa aaeo?eeo
(ai?ioeienaoeeio), a?aeiia?aeii 77,7 oa 98,2%. A?aoiaoth/e oeae oaeo,
aeey e?eoaaeueii-i?io?eaeoe/ieo ia?iaie iiaeia cai?iiiioaaoe oe?
i?aia?aoe.

I?ioeeaeoeea inaaaeiiiiico n?euenueeiainiiaea?nueei? ioeoe?.Ae?iaie/?
aeine?aee i?iaaaeai? a oiiaao aeaio ainiiaea?noa Noinueei? ?
Aeiiaoeueei? iaeanoae: aa?io??ia “Ai?eeoey” E?aniii?euenueeiai ?aeiio oa
AeII? ?i.*eaeiaa ssneioaaonueeiai ?aeiio. ?c ?ieoaaoe?eiiai yeoey oeeo
ainiiaeainoa ia i?ioyc? anueiai ?ieoaaoe?eiiai naciio 1997-1998 ?ie?a
ia??iaee/ii ?ciethaaeanue P.aeruginosa a 20,3-25%. ?acoeueoaoe
aeine?ae?a iaaaaeaii a oaaeeoe? 3.

Oaaeeoey 3

?acoeueoaoe ae?iaie/iai aenia?eiaioo ii i?io?eaeoeoe? inaaaeiiiiico

Ainiiaea?noai A?oie E?euee?noue aie?a, oen. I?aia?ao Aeica Oa?i?i
canoinoaaiiy, ae?a Can?a

canoino-aaiiy Ca 30 ae?a

caaeioei aeaeeei

aie?a % aie?a %

A.O.

“Ai?eeoey”

Noinueea iaeanoue 1 11,7 10%

aaeo?ee 10

ia/ea 3 c

ieoiith aiaeith 901 7,7 10799 92,3

2 10,8 4%

aaioai?-oeei 2

ia/aie 5 aa?icieueii 1987 18,4 8813 81,6

3 13,2 iie?i?e-neio I

noeueoao 4

ia/ea 5 c

ieoiith aiaeith 4118 31,2 9082 68,8

AeII?

?i.*eaeiaa

Aeiiaoeueea

iaeanoue 1 13,9 10%

aaeo?ee 10

ia/ea 3 c

ieoiith aiaeith 889 6,4 13011 93,6

2 12,2 iie?i?e-neio I

noeueoao 4

ia/ea 5 c

ieoiith aiaeith 2891 23,7 9309 76,3

Aeai? oaaeeoe? na?ae/aoue, ui caa?aaeai?noue eo?/ao eieeaaeanue a
caeaaeiino? a?ae i?aia?aoo, yeee aeei?enoiaoaaany. Oae, i?e
i?io?eaeoeoe? inaaaeiiiiico aaeo?eeii caa?aaeai?noue aoea 92,3 oa 93,6%,
aaioai?oeeiii – 81,6% oa iie?i?eneiii – 68,8 oa 76,3%.

Aeiiii?/ia aoaeoeai?noue i?iaaaeaieo aaoa?eia?ieo caoiae?a.Aeiiii?/ia
aoaeoeai?noue i?iaaaeaieo caoiae?a ii i?io?eaeoeoe? inaaaeiiiiico a AO
“Ai?eeoey” E?aniii?euenueeiai ?aeiio Noinueei? iaeano? a ii??aiyii? c
aaciaith (3 a?oiith aea aoei canoiniaaii iie?i?eneio I noeueoao) aeey
ia?oi? a?oie (i?e canoinoaaii? 10%-ai aaeo?eeo) neeaea 490,62 a?eai? ia
1000 aie?a eo?/ao, aeey ae?oai? a?oie (i?e canoinoaaii? 4%-ai
aaioai?oeeio) neeaea 227,17 a?eaaiue ia 1000 aie?a eo?/ao.

AENIIAEE

1.A inoaii? ?iee a ioaoiainiiaea?noaao Oe?a?ie a?aei?/a?oueny
i?aeaeuaiiy e?eueeino? niiioaiieo aeiaaee?a inaaaeiiiiico na?aae
aia??ii?a ? iieiaeiyea 1-30-aeaiiiai a?eo oa aei?inei? ioeoe?, ye?
ca?aaeothoueny aa?oeeaeueiei oa ai?eciioaeueiei oeyoaie. Ia ?nio?
ocaaaeueiaieo caoiae?a i?io?eaeoeee oa ai?ioueae c inaaaeiiiiicii
n?euenueeiainiiaea?nueei? ioeoe? a no/anieo oiiaao.

2.Caoai?thaaiiy ia inaaaeiiiiic na?aae n?euenueei-ainiiaea?nueei? ioeoe?
iia’ycaia c o?aaeaiiyi ?? iaoiaaiieie na?iaa??aioaie I2, I4, I5, I6, I8
P.aeruginosa. O 9% ai?ciioe/ieo eoeueoo? ia aecia/aii aioeaaiii?
i?eiaeaaeiino?. Aeiaaaeaia aeniea a??oeaioi?noue na?iaa??aio?a I4, I5,
I8 aeey aia??ii?a an?o aeae?a n?euenueeiainiiaea?nueei? ioeoe?.

3.Iacaeaaeii a?ae ia’?eoo ?cieyoe?? oa ?aa?iio, ??ci? ai?ciioe/i?
eoeueoo?e P.aeruginosa a a?eueoino? aeiaaee?a iathoue oeiia? a?ieia?/i?
aeanoeaino?, ui i?eoaiaii? oeei i?e?ii?aai?ciai.

4.Anoaiiaeaia aeniea /ooeea?noue aei P.aeruginosa eo?/ao (LD50 = 81
oen.i?e?.o?e) oa ia?aiaeaiyo (LD50 = 170 oen. i?e?.o?e).

5.O aaaaoueio ai?ciioe/ieo eoeueoo? P.aeruginosa aeae?eaieo c
iaoieia?/iiai iaoa??aeo a ??cieo iaeanoyo Oe?a?ie anoaiiaeaii iiii- oa
iie??acenoaioi?noue aei iiiii?oeeio, iie?i?eneio, no?aioii?oeeio,
oao?aoeeee?io, aii?oeee?io, eaaii?oeaoeio, i?e aenie?e /ooeeaino? aei
ai?ioeienaoeeio (aaeo?eeo) – 93,2, oa aaioai?oeeio – 73,6%.

6.Cai?iiiiiaaii iiaa naeaeoeaia na?aaeiaeua aeey aeae?eaiiy c ia?aeiiiai
iaoa??aeo ? eoeueoeaoaaiiy P.aeruginosa. Na?aaeiaeua caeaoia
aeoea?coaaoe ooai?aiiy i?aiaioo i?ioeeai?io oa i?i?oa?io.

7.?ic?iaeaia noaia aeae?eaiiy oa ?aeaioeo?eaoe?? P.aeruginosa c
aeei?enoaiiyi cai?iiiiiaaiiai iiaiai naeaeoeaiiai na?aaeiaeua aeey
?cieyoe?? neiueiai?eii? iaee/ee, ui aeicaiey? nei?ioeoe oa?i?i
ae?aaiinoeee oai?iae aei aeaio aei?a.

8.P.aeruginosa aeeeeea? caaeaaeue aia??ii?a ??cieo aeae?a
n?euenueeiainiiaea?nueei? ioeoe? o ae?oa?e iieiaei? ?ieoaaoe?? c
o?aaeaiiyi eaaaiue a 60% aeiaaee?a ? ia/?iee -30%.

9.I?e aenia?eiaioaeueiiio ? niiioaiiiio inaaaeiiiiic? iaoieiaiaiaoii?/i?
ci?ie o eo?/ao ciaoiaeeee a eaaaiyo (aei 50%), o eo?ae – a aa?oi?o
aeeoaeueieo oeyoao oa eaaaiyo (eaoa?aeueia a?iioiiiaaiii?y) a 40%
aeiaaee?a.

10.I?e canoinoaaii? c i?io?eaeoe/iith iaoith 10%-ai aaeo?eeo oa 4%-ai
aaioai?oeeio a ainiiaea?noaao, aea niinoa??aaany inaaaeiiiiic na?aae
eo?/ao ia?oeo aei?a aeeooy anoaiiaeaii caa?aaeai?noue: 92,3, 93,6% oa
81,6% a?aeiia?aeii.

11.Iaea?eueo aoaeoeaiei aoei canoinoaaiiy aaeo?eeo, a ii??aiyii? c
canoinoaaiiyi iie?i?eneio ? neeaei 490,62 a?eai? ia 1000 ia?iaeaieo
eo?/ao, a aaioai?oeeio 227,17 a?eaaiue a?aeiia?aeii.

Nienie iioae?eiaaieo i?aoeue caeiaoaa/a ca oaiith aeena?oaoe??

1.Cii A.A., Ne?eiea I.A. Inaaaeiiiiic ioeoe? // Oaa?eiieoeoai Oe?a?ie.-
1995.- ? 4-5.- N. 20-21.

2. Cii A.A., Ne?eiea I.A. Iniiai? a?ieia?/i? aeanoeaino? caoaeiee?a
inaaaeiiiiico ioeoe?, aeae?eaieo a ainiiaea?noaao Oe?a?ie // A?niee
NAeAO.- 1998.- ?2.- N. 166.

3. Iaaeaiei I., I?eueei E., Iai/aiei A., Otho/aiei TH., N?aeeo O.,
Ne?eiea I. *ooeea?noue caoaeiee?a oai?ia oaa?ei aei aioeaaeoa??aeueieo
i?aia?ao?a iiaiai iieie?iiy // Aaoa?eia?ia iaaeeoeeia Oe?a?ie.- 1997.-
?11.- N. 12-13.

4.Cii A.A., Ne?eiea I.A. Inaaaeiiiiic, ye i?e/eia aia??iiaeueii?
caaeaae? n?euenueeiainiiaea?nueei? ioeoe? // ? iaoeiaa eiioa?aioe?y ii
ioao?aieoeoao: oace aeiiia?ae?.- Ai?ee-N?ioa?iiieue., 1993.- N. 115.

5.Cii A.A., Ne?eiea I.A. Aea/aiiy a?ieia?/ieo aeanoeainoae ai?ciioe/ieo
eoeueoo? P.aeruginosa // Iai?yiee i?aeaeuaiiy i?iaeoeoeaiino? oa yeino?
n?euenueeiainiiaea?nueei? i?iaeoeoe??: Ca.iaoe.i?aoeue Noinueeiai NAO.
Noie, 1995.- N. 80.

6.Cii A.A., Ne?eiea I.A., Oo?/eia N.A. Iaoieiaiaiaoiie/aneea eciaiaiey
i?e inaaaeiiiiica yia?eiiia, iieiaeiyea e ac?ineie ioeoeu // ??
Oe?aeineay eiioa?aioeey ii ioeoeaaiaenoao: o?oaeu eiioa?aioeee.- Ai?ee.,
1996.- N.- 48-49.

7.Iai?ea? ?.?., Ne?eiea I.A. A?ieia?/i? aeanoeaino? caoaeieea
inaaaeiiiiico ioao?a oa eiai /ooeea?noue aei aioea?ioee?a // A?niee
Iieoaanueeiai AeNA?.- 1998.- ?1. N. 40-41.

8.Oo?/eia N.A., Cii A.A., Ne?eiea I.A. Ecuneaiea iiauo n?aaenoa aeey
ai?ueau n inaaaeiiiiicii ioeoe // ?? Oe?aeineay eiioa?aioeey ii
ioeoeaaiaenoao: o?oaeu eiioa?aioeee.- Ai?ee., 1996.- N.- 126.

Ne?eiea I.A. Inaaaeiiiiic ioeoe? a Oe?a?i? oa a?ieia?/i? aeanoeaino?
caoaeieea — ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa aaoa?eia?ieo iaoe c niaoe?aeueiino? 16.00.03 — aaoa?eia?ia
i?e?ia?ieia?y oa a??onieia?y.

?inoeooo aenia?eiaioaeueii? ? ee?i?/ii? aaoa?eia?ii? iaaeeoeeie OAAI,
Oa?e?a, 1999

Aeena?oaoe?y i?enay/aia aea/aiith inaaaeiiiiico a Oe?a?i? oa aea/aiith
a?ieia/ieo aeanoeainoae caoaeieea, ?ic?iaoe? iaoiae?a ?cieyoe?? oa
?aeaioeo?eaoe?? P.aeruginosa, a oaeiae ?ic?iaoe? iaoiae?a ae?aaiinoeee
oa i?io?eaeoeee oai?iae. Cai?iiiiiaaia noaia ?cieyoe?? P.aeruginosa ?c
??cieo aeaea?ae. Anoaiiaeaia /ooee-a?noue eo?/ao ? ia?aiaeaiyo aei
inaaaeiiii, ye? aoee ?cieueiaai?.

Aea/aia /ooeea?noue P.aeruginosa aei ??cieo aioea?ioee?a. Anoaiiaeaii,
ui a?eueo?noue inaaaeiiii /ooeea? aei aaeo?eeo (ai?ioeienaoeeio) ?
aaioai?oeeio.

Eeth/ia? neiaa: ioeoey, inaaaeiiiiic, ?cieyoe?y, caoaeiee, a?ieia?/i?
aeanoeaino?.

Ne?eiea I.A. Inaaaeiiiiic ioeoeu ia Oe?aeia e aeieiae/aneea iniaaiiinoe
aicaoaeeoaey — ?oeiienue. Aeenna?oaoeey ia nieneaiea o/?iie noaiaie
eaiaeeaeaoa aaoa?eia?iuo iaoe ii niaoeeaeueiinoe 16.00.03 — aaoa?eia?iay
ae?onieiaey e iee?iaeieiaey.

Einoeooo yenia?eiaioaeueiie e eeeii/aneie iaaeeoeeiu OAAI, Oa?ueeia,
1999.

Caueuathony ?acoeueoaou enneaaeiaaiee ii eco/aieth inaa-aeiiiiica ioeoe
ia Oe?aeia, aeieiae/aneeo naienoa aicaoaeeoaey, aai /oanoaeoaeueiinoe e
aioeaaeoa?eaeueiui i?aia?aoai, ?ac?aaioee iaoiaeia aeeaaiinoeee e
i?ioeeaeoeee caaieaaaiey.

Aicaoaeeoaeue neiaaiieiie eioaeoeee – i?aaenoaaeoaeue iaeiiai ec aeaeia
aaeoa?ee, eioi?ua yaeythony iaoiaaiiuie eae aeey ethaeae, oae e aeey
aeeaioiuo. Inaaaeiiiiic ?ani?ino?aiai a ?acee/iuo
no?aiao ie?a.

P.aeruginosa auea auaeaeaia io aiaeiieaaathuae ioeoeu, iiioaaaa,
oacaiia, aieoaae e ia?aiaeia. I inaaaeiiiiica ioeoeu a oicyenoaao
Oe?aeiu niiauaiee iaeaeaii ia auei.

Aeena?oaoeey iinayuaia eco/aieth inaaaeiiiiica a Oe?aeia e eco/aieth
aeieiae/aneeo iniaaiiinoae aicaoaeeoaey, ?ac?aaioea iaoiaeia ecieyoeee e
eaeaioeoeeaoeee P.aeruginosa, a oaeaea ?ac?aaioea iaoiaeia aeeaaiinoeee
e i?ioeeaeoeee aieacie.

A ?aaioa aia?aua i?eaiaeyony aeaiiua i iiyaeaiee niii-oaiiuo aniuoae
inaaaeiiiiica n?aaee iieiaeiyea e ac?ineuo ioeoe, iniaaiii a oicyenoaao,
aaea aicaoaeeoaeue auaeaeyaony io yia?eiiia. Ca?aaeaiea i?ienoiaeeei
aa?oeeaeueiui e ai?eciioaeueiui iooai.

Yenia?eiaioaeueii aeieacaia aiciiaeiinoue ca?aaeaiey aicaoaeeoaeai
inaaaeiiiiica, auaeaeaiiiai io ?acee/iuo aeaeia ioeoe, i?iaaaeaia
n?aaieoaeueiay ioeaiea iniiaiuo naienoa eoeueoo? P.aeruginosa e
aeieacaia eaeaioe/iinoue yoeo naienoa o ?acee/iuo eoeueoo?, eciee?iaaiuo
a ?aciuo iaeanoyo Oe?aeiu. Onoaiiaeaia aini?eei/eainoue oeuieyo e
ia?aiaeyo e eciee?iaaiiio aicaoaeeoaeth.

Ia iniiaaiee eco/aiey naienoa aicaoaeeoaey inaaaeiiiiica ?ac?aaioaia
ieoaoaeueiay n?aaea (niaea?aeauay ii/aaeio) aeey eoeueoeae?iaaiey
P.aeruginosa. I?aaeeiaeaia noaia auaeaeaiey e eaeaioeoeeaoeee
aicaoaeeoaey inaaaeiiiiica, eioi?ay ioee/aaony io iauai?eiyouo
eniieueciaaieai iaiueoaai eiee/anoaa ieoa-oaeueiuo n?aae e oiaiueoaieai
cao?ao a?aiaie aeey i?iaaaeaiey eaai?aoi?iuo enneaaeiaaiee.

Eco/ai niaeo? /oanoaeoaeueiinoe e aioeaaeoa?eaeueiui i?aia?aoai
?acee/iuo eoeueoo? P.aeruginosa, eciee?iaaiuo io ioeoeu. Iieo/aiiua
aeaiiua naeaeaoaeuenoaotho i iaeaieueoae /oanoaeoaeueiinoe aicaoaeeoaey
inaaaeiiiiica e aaeo?eeo (yi?ioeienaoeeio) e aaioaieoeeio, /oi iicaieyao
?aeiiaiaeiaaoue yoe i?aia?aou aeey ea/aiey eioeoee?iaaiiie aicaoaeeoaeai
ioeoeu.

?ac?aaioaiu (a niaaoi?noaa) e i?aaeeiaeaiu aeey i?iecaiaenoaa
“Iaoiaee/aneea ?aeiiaiaeaoeee ii aeeaaiinoeea e i?ioeeaeoeea
inaaaeiiiiica naeuenei-oicyenoaaiiie ioeoeu”.

Eeth/aaua neiaa: ioeoea, inaaaeiiiiic, ecieyoeey, aicaoaeeoaeue,
aeieiae/aneea naienoaa

Skripka M.V. The Psevdomonosis of poultry in Ukraine and biological
properties of causal of agent — manuscript. The dissertation of
candidate’s degreein veterinary sciense on speciality 16.00.03 —
vetetinary microbiology and virology.

Institute of Experimental and Clinical Veterinary Medicine of UAAS?
Kharkov? 1999

The dissertation is devoted to the study of Psevdomonosis in Ukraine and
of biological properties of causal agent and development of the methods
of isolation and identification P.aeruginosa and development of the
methods of diagnostic and prophylaxis the disease.

The sheme of Psevdomona isolation from various sourse has been
proposed. The sensitivity of chickens and quails to P.aeruginosa were
established.

The study of sensitivity of P.aeruginosa to the various antibiotics.
The majority of pseudomonas were sensitivity to Baytril (enrofloxacin)
and gentamicin.

Key words: poultry, Pseudomonosis, growing of causal agent, biological
properties.

E?euee?noue ?cieyo?a

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