.

Прогноз, профілактика та лікування ускладнених форм кору: Автореф. дис… д-ра мед. наук / І.Б. Єршова, Київ. НДІ епідеміології та інфекц. хвороб ім.

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IAOEIAI-AeINE?AeIEE ?INOEOOO

AI?AeAI?IEIA?? OA ?IOAEOe?EIEO OAI?IA

?iai? E.A.A?IIAOAANUeEIAI

??OIAA ??EIA AI?EN?AIA

OAeE 616.915-06-08.001.18

I?IAIICOAAIIss, I?IO?EAEOEEA OA E?EOAAIIss ONEEAAeIAIEO OI?I EI?O

14.01.13 – ?ioaeoe?ei? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

Iaoeia? eiinoeueoaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? O?ieia Aaea??e Ieo?ioaiiae/,
Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa. eaoaae?e
?ioaeoe?eieo oai?ia oa ai?aeai?ieia??

caneoaeaiee ae?y/ iaoee Oe?a?ie, eao?aao Aea?aeaaii? i?ai?? Oe?a?ie,
aeieoi? iaaee/ieo iaoe, i?ioani? A?iiaoaanueea Ethaia Eaiio??aia,
EIAe?A?O ?i. E.A. A?iiaoaanueeiai, caa?aeoth/a eaai?aoi??? ee?i?/ii?
a?io?i??

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Iinothe Aaiaoa ?aai?aia, EAeIO,
caa.eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia,

aeieoi? iaaee/ieo iaoe, i?ioani? O??oeiaa E?y Ieaen??aia, Iaoe?iiaeueiee
iaaee/iee oi?aa?neoao ?i.aeaae. I.I.Aiaiiieueoey IIC Oe?a?ie, i?ioani?
eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia,

aeieoi? iaaee/ieo iaoe, i?ioani? Eeieai Aai?a?e Ieeiea?ae/ Ee?anueea
iaaee/ia aeaaeai?y i?neyaeaieiiii? ina?oe ?i. I.E.Ooi?ea, caa. eaoaae?e
ee?i?/ii? eaai?aoi?ii? ae?aaiinoeee

I?ia?aeia onoaiiaa: Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC
Oe?a?ie

Caoeno a?aeaoaeaoueny “21”/a?aiy 1999 ?ieo ia10 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae .26.614.01 i?e Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?iai? E.A.A?iiaoaanueeiai IIC Oe?a?ie ca aae?anith: 252150, i.Ee?a,
aoe.N?/iaaiai iianoaiiy, 23

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? EIAe?A?O IIC Oe?a?ie
(252150, i.Ee?a, aoe.N?/iaaiai iianoaiiy, 23)

Aaoi?aoa?ao ?ic?neaiee “20”o?aaiy1999?ieo

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe,
___________ A.Ae.Aiae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

E??, iacaaaeath/e ia i?iaaaeaiiy oe?iei? i?ia?aie ?ioi?caoe??, aei
inoaiiueiai /ano caeeoa?oueny iaei??th c iaea?eueo ?iciianthaeaeaieo
aeeoy/eo e?aiaeueieo ?ioaeoe?e. Ca aeaieie AIC caoai?thaai?noue ia e??
ui??/ii neeaaea? a?ey 70 iei /ieia?e e yaey? cia/io caa?ico aeey
caei?ia’y oa aeeooy ye ae?oae, oae ? aei?ineiai ianaeaiiy. E?? cia/ii
iineaaeth? ?ioiio nenoaio i?aai?cio ? a?aee?eaa? oeyo aei ?ioeo aino?eo
? o?ii?/ieo ?ioaeoe?e. Onoaiiaeaii, ui ?aeeiith i?e/eiith nia?oiino?
a?ae ei?o noathoue eiai oneeaaeiaiiy (E.A.Aeno?yeiaa, 1992). Iaciaiiy
iaoiaaiaco ?o oi?ioaaiiy i?e??aith?oueny aei iaciaiiy naii? oai?iae.

Aeooaeuei?noue oaie. Uaieaiiy i?ioe ei?o a iaeaeeae/? ?iee ia ae??oeoue
on?o i?iaeai oe??? ?ioaeoe??, ai ca aeaieie io?oe?aeueii? noaoenoeee o
15-20% ae?oae aioeo?ea i?ioe ei?o ia ae?iaeythoueny (E.I.*oaeia, 1997).
E?euee?noue oaeeo ae?oae ii e?a?i? neeaaea? a?ey 1,5 iei., ui noa?
iniiaith aeey ai?aeai?/iiai i?ioeano. Ia aeeaey/enue ia iioe?aiiy
e?eoaaeueieo iiaeeeainoae, ca inoaii? 10 ?ie?a oneeaaeiaiiy ei?o ia
iathoue oaiaeaioe?th aei cieaeaiiy ? i?aaenoaaeythoue ?aaeueio caa?ico
aeey aeeooy. Ioaea, aeioe?eueii aea/eoe iaoiaaiaoe/i? iniaeeaino?
?icaeoeo oa i?iaiicoaaiiy oneeaaeiaieo ? oyaeeeo oi?i oai?iae, ui
aeicaieeoue aeei?enoaoe io?eiai? aeai? aeey iiooeo a?eueo aoaeoeaieo
cania?a i?io?eaeoeee ? e?eoaaiiy.

Ca inoaii? ?iee iniaeeao oaaao aeine?aeiee?a i?eaa?oathoue ci?ie
iieaciee?a iaoaaie?/iiai aiiainoaco i?e ??cieo iaoieia?/ieo noaiao.
I?aeaeuai? eiioeaio?aoe?? i?e?iaeieo iaoaaie?o?a, i?ii?aeieo ?
e?ioeaaeo ?a/iaei ?o iai?io iiaeooue i?iyaeyoe oiene/io ae?th ia
i?aai?ci ethaeeie, aeeeeeath/e noai “iaoaaie?/ii? ?ioieneeaoe??” (E.E.
A?iiaoaanueea, 1990, 1996, 1997). Aeine?aeaeaiiy a oeueiio iai?yieo
aeathoue iiaeeeaino? c’ynoaaiiy cia/aiiy o oi?ioaaii? iani?eyoeeaiai
ia?aa?ao oai?iae i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a (IIE),
iaoaaie?cio aeeicaii?ae?a, iae?iiaioeae?a, ai?iii?a aeei/eiai? caeice e
nenoaie aaiinoaco.

Oa?aeoa?, /anoioa oneeaaeiaiue oa nia?oi?noue a?ae ei?o a cia/i?e i???
caeaaeeoue a?ae noaio ?ioiii? nenoaie (A.I.O?ieia oa ni?aaao., 1991,
1994). I?e oeueiio aaeeea ?ieue a oi?ioaaii? ?ioiiiai aeao?oeeoo
iaeaaeeoue nenoai? HLA, yea o?nii iia’ycaia c aaiaie ?ioiii? a?aeiia?ae?
(A.I.Ae?aii?e, oa ni?aaao.1990).

Iniaeeao oaaao i?eaa?oathoue aeai?, i?aaenoaaeai? niaoe?ae?noaie
Ee?anueeiai IAeO ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i.E.A.A?iiaoaanueeiai, noiniaii i?eai?/oth/iai aieeao aeieia?/ieo
caa?oaeiaiue ia ??aaiue

?ioi?oaoo ae?oae oa aei?ineeo a aeieia?/ii iani?eyoeeaeo ?aa?iiao
(E.I.*oaeia oa ni?aaao., 1993; TH.A. Aa?ooaei, 1997).

Aaaeeeaa ?ieue o oi?ioaaii? ?ioiiaeao?oeeoieo noai?a a?aeaiaeeoueny
iaaeinoaoiino? aioo??oiueinae?aoi?ii? ooieoe?? aeei/eiai? caeice –
oeaio?aeueiiai i?aaio ?ioiii? nenoaie. ?ai?oa aoee io?eiai? aeai? i?i
aaciina?aaei?e aieea ai?iii?a oeiono, cie?aia, oeiiceio, ia
iae?iaiaeie?eii? ooieoe?? i?aai?cio (G. Millington, J.C. Buckingham,
1992; A.A.ss?ee?i, 1998). Ia iao iiaeyae ia?niaeoeaiei aoei a aea/aiiy
iniaeeainoae iaoiaaiaco ei?o e ?icaeoie eiai oneeaaeiaieo oi?i
iaoiaeaie ?ioiia?io?i??, ? cie?aia aea/eoe aca?iica’ycie i?ae
iaae?aoi?aie ?ioiii?, iae?iaiaeie?eiii? nenoai, a oaeiae iae?iiaioeaei?
iaoai?cie ?aaoeyoe?? ?ioi?oaoo.

Ia iaio cia/iei aniaeoii o ae??oaii? i?iaeaie ei?iai? ?ioaeoe?? ? iiooe
iiaeo aoaeoeaieo cania?a, caeaoieo caaacia/eoe iioeiaeueiee ?icaeoie
i?ioean?a naiiaaiaco e caiia?aoe iani?eyoeeaiio ia?aa?ao ? caaa?oaiith
oai?iae.

Caeaoi?noue a??ono ei?o aeeeeeaoe noai aia?a?? iio?aao? iaia’yceiaiai
aeei?enoaiiy a eiiieaeni?e iaaeeeaiaioici?e oa?ai?? i?aia?ao?a
?ioiio?iiii? ae??. ?ai?oa aoei iaa?oioiaaii iaoiaaiaoe/ia aeei?enoaiiy
i?e oyaeeeo oi?iao ei?o nieai?io, ioeea?iaoo iao??th, ?iaeoeoi?a neioaco
aiaeiaaiiiai ?ioa?oa?iio – iaoaiai?iiai? eeneioe, oieioa?ieo aoeaoaoo
(O.?.??oia, 1989; ?.I.Iicaeiyeiaa, 1992). Iaeiae aeei?enoaiiy oeacaieo
i?aia?ao?a o eiiieaeni?e oa?ai?? ei?o ia caaaeaee i?eiineei i/?eoaai?
?acoeueoaoe. Oiio aaeee? niiae?aaiiy iieeaaeathoueny ia
aeeoa?aioe?eiaaia aeei?enoaiiy iiaeo eiia?iaoe?e i?aia?ao?a, ae?y yeeo
aoea a ni?yiiaaia ia ??ci? eaiee iaoiaaiaco ei?o, c o?aooaaiiyi a?eo
oai?eo, oyaeeino? i?ioeano, iayaiino? oneeaaeiaiue.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

?iaioa aeeiioaaeanue ca?aeii ieaio IAe? Eoaainueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo a ?aieao aaeocaai? i?ia?aie a iaeano?
iaaeeoeeie N. 14 “Aea/aiiy iaoeiaeo ? i?aai?caoe?eieo aniaeo?a
cieaeaiiy caoai?thaaiino? ianaeaiiy ?ioaeoe?eieie oai?iaaie ?
e?ea?aeaoe?? ea?iaaieo ?ioaeoe?e” ca oaiith IAe? eaoaae?e aeeoy/eo
oai?ia “Ee?i?ei-?ioiieia?/i? iniaeeaino? ei?o, i?iaiicoaaiiy iane?aee?a
a oiiaao i?iieneiaiai ?aa?iio” (? aea?ae?a?no?aoe?? 01900011624).

Iaoa aeine?aeaeaiiy: ?ic?iaea e?eoa???a i?iaiicoaaiiy oneeaaeiaiue i?e
ei?o, ?aoe?iiaeueieo i?eioeei?a ?o i?io?eaeoeee oa ei?aeoe?? aeyaeaieo
ii?ooaiue ia i?aenoaa? no/aniiai eiiieaeniiai aeine?aeaeaiiy ee?i?/ieo,
aaiaoe/ieo, ?ioiieo, a?io?i?/ieo oa i?e?ioee?eoeyoi?ieo iniaeeainoae
iaoieia?/iiai i?ioeano.

A?aeiia?aeii aei oeacaii? iaoe aeine?aeaeaiiy aoee iinoaaeai? oae?
eiie?aoi? caaaeaiiy:

1. I?iaiae?coaaoe oa?aeoa? ? /anoioo ?icaeoeo oneeaaeiaiue o ae?oae ?
aei?ineeo oai?eo ia e?? c o?aooaaiiyi oyaeeino?, ia?aa?ao oai?iae, a?eo
oai?eo.

2. Aea/eoe cia/aiiy noaio oai?eo ia e??, yeee ia?aaeoaaa caoai?thaaiith
a ieai? ?iia??iino? ?icaeoeo oneeaaeiaiue.

3. Aeyaeoe iiaeeeao cia/ei?noue ?ioii-aaiaoe/ieo iieaciee?a a
i?aeaeuaii? nooiaith ?eceeo aeieeiaiiy oneeaaeiaiue.

4. Aea/eoe ai?no a1-oeiiceio (ai?iiio aeei/eiai? caeice) o oai?eo ia e??
oa eiai aca?iia?aeiioaiiy c ?ioiieia?/ieie iieacieeaie i?e iayaiino? ?
a?aenooiino? oneeaaeiaiue.

5. Aeine?aeeoe ?ioaineai?noue i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a
(IIE), aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie, ??aaiue ai?noo
aeeicaii?ae?a ? “na?aaei?o iieaeoe” “NI” a iaoiaaiac? neiae?iio
“iaoaaie?/ii? ?ioieneeaoe??” i?e ?icaeoeo oneeaaeiaiue.

6. Aeyaeoe caeiiii??iino? ci?i aiaeiaaiieo ii?i?aeieo iaioeae?a
(b-aiaei?o?io, iao?ii?i- ? eaeoeeo?i-aie?oae?io) o oai?eo ??cieie
oi?iaie ei?o, ?o aieea ia ?ioii? ? iaoaaie?/i? i?ioeane.

7. Aeine?aeeoe noai nenoaie i?e?ioee?eoeyoe??, aaiinoaco, ?o
aca?iiiaoiiaeai?noue c ?ioiieie ? iaoaaie?/ieie i?ioeanaie i?e
oneeaaeiaieo oi?iao ei?o.

8. Ia i?aenoaa? io?eiaieo aeaieo aeae?eeoe iaea?eueo ?ioi?iaoeai?
e?eoa???, ye? iathoue cia/ei?noue a i?iaiicoaaii? aeieeiaiiy
oneeaaeiaiue o oai?eo ia e??; iaa?oiooaaoe i?eioeeie ? eiie?aoi? niiniae
e?eoaaiiy a?oi ?eceeo ii ?icaeoeo oneeaaeiaiue.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. I?iaaaeaia eiiieaenia
aeine?aeaeaiiy c aeei?enoaiiyi ee?i?/ieo, a?io?i?/ieo, ?ioii-aaiaoe/ieo
iaoiae?a aeicaieeei ?icoe?eoe ? iiaeeaeoe oyao i?i iaoiaaiaoe/i?
iaoai?cie, ye? eaaeaoue a iniia? oneeaaeiaieo oi?i ei?o.

Aecia/aia ?ieue noaio i?aai?cio ia oii? yeiai ?icaeioeinue
caoai?thaaiiy, a?eo oai?eo oa iniaeeainoae ee?i?/iiai ia?aa?ao ei?o a
?icaeoeo oneeaaeiaiue.

Iieacaii cia/aiiy iayaiino? aioeaai?a HLA, oi?ioaaiiy o oai?eo ia e??
aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? o iaoiaaiac? oyaeeiai ?
oneeaaeiaiiai ia?aa?ao oai?iae. I?e oeueiio aia?oa aeyaeaia
iaaeinoaoi?noue ??aiy a1 – oeiiceio, ni?eyth/a oi?ioaaiith aoi?eiiiai
?ioiiaeao?oeeoiiai noaio o oai?eo ia e?? i?e oneeaaeiaiiio eiai
ia?aa?ao.

Onoaiiaeai? caeiiii??i? ci?ie iieaciee?a IIE, aeoeaiino? aioeia?aeenii?
nenoaie. Iieacaii, ui nooi?iue ae?aco ci?i aecia/a?oueny

oyaee?noth oai?iae ? iayai?noth oneeaaeiaiue. I?e ??cieo oi?iao ei?o
?niothoue ei?aeyoe?ei? ca’ycee i?ae IIE ? ?ioiieie iieacieeaie.

Aecia/ai? iniaeeaino? ci?i IA, ye? iathoue cia/aiiy o oi?ioaaii?
oneeaaeiaiue i?e ei?o.

Aeyaeaia ii?i?aeia aeoeai?noue e?ia? i?e ??ciiio ia?aa?ao ei?o.

Onoaiiaeai? iniaeeaino? aaiinoaco, i?e?ioee?eoeyoe?? i?e oneeaaeiaieo
oi?iao ei?o oa ?o aca?iica’ycie c ?ioiieie e iaoaaie?/ieie iieacieeaie.

?ic?iaeai?, iaoiaaiaoe/ii iaa?oioiaai?, e?eoa??? i?iaiicoaaiiy ?
oa?aiaaoe/i? caoiaee, ni?yiiaai? ia caiia?aaiiy ?icaeoeo oa e?eoaaiiy
oneeaaeiaieo ? oyaeeeo oi?i ei?o.

I?aeoe/ia cia/ei?noue io?eiaieo ?acoeueoao?a. Ia i?aenoaa? ee?i?/ieo,
iaoaaie?/ieo, ?ioiieo iieaciee?a aoa cai?iiiiiaaiee eiiieaen e?eoa???a
i?iaiicoaaiiy ?icaeoeo oneeaaeiaieo oi?i ei?o.

“A?oiith ?eceeo” ?icaeoeo oneeaaeiaiue ?aeiiaiaeo?oueny aaaaeaoe oai?eo
ia e??, o aiaiiac? yeeo iathoue i?noea iani?eyoeeaee noai, yeee
ia?aaeoaaa oai?ia? (o?ii?/i? ?iceaaee o?aaiaaiai o?aeoo, aa?oai?iice,
caoai?thaaiiy iiniaeioee, aeeoaeueii? nenoaie, ia??iae
?aeiiaaeanoeaioe?? ?ioeie ?ioaeoe?eieie oai?iaaie, iiaoi?i? ?ani??aoi?i?
?ioaeoe??), a?aenooi?noue aaeoeeiiuaieaiiy, a?e aei 3 ?ie?a.

Iayai?noue o oaiioei? aioeaai?a nenoaie HLA-A2, A7, A13, Bw35, DR2, ?
a?aenooi?noue aioeaai?a A1, A11, A8 i?eionea? oyaeeee ? oneeaaeiaiee
ia?aa?a ei?o.

Cieaeaiiy ??aiy CD3 – e?ioioeeo?a aei 35% a?eiai? ii?ie o ae?oae ? 40% o
aei?ineeo, ni?aa?aeiioaiiy CD4/CD8 aei 1,3 ? 1,0, i?aeaeuaiiy
eiioeaio?aoe?? Oe?E a?eueoa 3,2 a/e ? 4,5a/e, i?aeaeuaiiy ?AIE aei OA
aei 0,9 ? 0,6 ? iani?eyoeeaeie ?ioiieia?/ieie iciaeaie oi?ioaaiiy
oneeaaeiaiue ? oyaeeiai ia?aa?ao oai?iae.

I?e ai?no? IAeA aei 41,5 ieiieue/e e 61,0 ieiieue/e ? aeua o ae?oae oa
aei?ineeo a?aeiia?aeii, cieaeaii? ni?aa?aeiioaiiy 6-eaoi-IAF1a/OoA2 aei
0,7 ? 1,0, i?aeaeuaii? ni?aa?aeiioaiiy IAF2a/IAA2 aei 3,0 ? 3,5,
ciaioaii? ai?noo a1-oeiiceio aei 1,0 ia/ie ? 0,4 ia/ie, iiaeia
ia?aaeaa/eoe oyaeeee ia?aa?a ei?o c oneeaaeiaiiyie.

Ca aeiiiiiaith ?aa?an?iiiiai aiae?co aoei ?ic?aoiaaii ii??aiyiiy
?aa?an?? ca aeiiiiiaith yeiai ii e?eueeino? CD4 e?ioioeeo?a iiaeeeai
iina?aaeiuei noaeeoe i?i ai?no a1-oeiiceio (a1-oeiicei = – 0,3524 +
0,03837 • CD4).

Cai?iiiiiaai? iaoiaaiaoe/ii iaa?oioiaai? i?aeoiaee aei e?eoaaiiy oa
iiia?aaeaeaiiy ?icaeoeo oyaeeeo oa oneeaaeiaieo oi?i ei?o ?c
canoinoaaiiyi aioeieneaeaio?a (oieioa?ieo aoeaoaoo ? anei?a?iiai?
eeneioe

o ae?oae ? aio?aeth o aei?ineeo), oa i?e cieaeaii? ai?iiiaeueii?
ooieoe?? oeiono – i?aia?ao?a ?ioiiiiaeoethth/i? ae?? (oeiiaaeneio).

Ao?eaiiy a i?aeoeeo io?eiaieo ?acoeueoao?a. ?acoeueoaoe i?iaaaeaieo
aeine?aeaeaiue ? ee?i?/ieo niinoa?aaeaiue ai?iaaaeaeai? a i?aeoeeo
?iaioe e?eoaaeueieo caeeaae?a Eoaainueei?, Euea?anueei?, Aeiiaoeueei?,
Oa?e?anueei?, *a?eanueei?, *a?i?aaoeueei? iaeanoae Oe?a?ie. Iaea?aeai?
iia? aeai? aeeth/ai? aei iaa/aeueiiai i?ioeano 5 iaaee/ieo AIC?a oa
?inoeooo?a oaeineiiaeaiiy e?ea??a Oe?a?ie. Iniiai? ?acoeueoaoe
aeine?aeaeaiiy aeeeaaeai? a iiiia?ao?? “Ei?ue (eeeieea e iaoiaaiac)”, a
oaeiae aeeth/ai? o 2 iaoiaee/i? ?aeiiaiaeaoe?? aeey e?ea??a oa
noai?aeeiaoi??a ii ae?aaiinoeoe? oa e?eoaaiith oneeaaeiaieo oi?i ei?o.

Iniaenoee aianie aaoi?a. Ianoaaeaii 617 oai?eo ia e?? c?
na?aaeiueioyaeeei ? oyaeeei ia?aa?aii; – aeeiiaia ia?aaaaeia /anoeia
aeine?aeaeaiue o aea/aii? iaoaaie?/ieo oa ?ioiieo iniaeeainoae
iaoieia?/iiai i?ioeano o ianoaaeaieo oai?eo; o /anoeie oai?eo o
aeeiai?oe? oai?iae aaciina?aaeiuei i?iaaaeaii ianoaaeaiiy
i?e?ioee?eoeyoe??.

?ic?iaeaia oa ee?i?/ii aei?iaoaaia eiia?iiaaia oa?ai?y oneeaaeiaieo oi?i
ei?o c aeei?enoaiiyi aioeieneaeaioieo oa ?ioiio?iiieo cania?a, aeaia
ioe?iea aoaeoeaiino? cai?iiiiiaaiiai e?eoaaiiy; i?iaaaeaia noaoenoe/ia
ia?iaea io?eiaieo aeaieo ca aeiiiiiaith AII.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue oa iaaiai?thaaeenue ia ?aa?iiaeuei?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeeyiea oaeoi?ia aiaoiae n?aaeu ia
?aaeoeaiinoue i?aaiecia” (Ee?a-Ai?ioeeiaa?aae, 1990), 4-e
i?ae?aa?iia?i?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeueiua i?iaeaiu
eioaeoeeiiiie iaoieiaee, eeeie/aneie eiioiieiaee e iaaeeoeeineie
aaiaoeee” (Iineaa-Eoaainuee,1991), i?ae?aa?iiaeuei?e iaoeia?e
eiioa?aioe?? ?ioiieia?a, ?ioaeoe?ii?no?a, aaiaoee?a, aea?aieia?a
(Iineaa-Eoaainuee, 1992), ?aa?iiaeuei?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Yeieiaey Aeiiaanna” (Eoaainuee, 1993), ia ?anioae?eainueeiio nai?ia??
“Aeieia?y, ?ioi?oao oa caei?ia’y ianaeaiiy” (Ee?a-Eoaainuee, 1994), II
iaoeiaiio neiiic?oi? “Aeooaeuei? i?iaeaie aeieia?/ii? oa ee?i?/ii?
?ioiieia??” (Ee?a-Eoaainuee,1994), III iaoeiaiio neiiic?oi? “Aeooaeuei?
i?iaeaie aeieia??, ee?i?/ii? ?ioiieia?? oa ?ioaeoe?eii? iaoieia??”
(Ee?a-Eoaainuee, 1995), tha?eaei?e iaoeiai-i?aeoe/i?e eiioa?aioe??,
i?enay/ai?e 100-??//th 4-? i?nueei? e?ea?i? i.Eoaainueea
(Eoaainuee,1995), iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 35-??//th
eaoaae?e nioe?aeueii? iaaeeoeeie, i?aai?caoe?? oa aeiiii?ee ioi?iie
caei?ia’y “Caei?iauea ianaeaiey: nioeeaeueii-yeiiiie/aneea aniaeou,
i?aaiecaoeey iaaeeoeeineiai

ianeoaeeaaiey” (Eoaainuee, 1995), ni?euei?e iaoeia?e nan??
“Ineoiniiaoe/aneea ?ano?ienoaa” (Oa?e?a-Eoaainuee,1995), XIII c’?cae?
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a oa
ia?aceoieia?a ?i. Ae.E.Caaieioiiai (Ee?a-A?iieoey, 1996), iaeanieo ?
?aa?iiaeueieo eiioa?aioe?yo, nai?ia?ao ? can?aeaiiyo iaoeiai-i?aeoe/ieo
oiaa?enoa ?ioaeoe?ii?no?a, iaae?ao??a, a?io?i?e?a, ?ioiieia?a (E?aniee
Eo/, 1993; E?n?/ainuee, 1995; Eoaainuee, 1994-1997).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 44 ?iaioe a oiio /ene?
1 iiiia?ao?y, 22 iaoeia? ?iaioe o i?io?eueieo iaaee/ieo aeaeaiiyo, 19
oac eiioa?aioe?e, 2 iaoiaee/i? ?ic?iaee.

No?oeoo?a oa ianya aeena?oaoe??. ?iaioa aeeeaaeaia ia 311 noi??ieao
iaoeiiieno, aeeth/a? 8 aeienie ?c ?noi??e oai?iae. Aeena?oaoe?y
neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, iieno iaoa??ae?a oa
iaoiae?a aeine?aeaeaiiy, 5 ?icae?e?a aeanieo aeine?aeaeaiue, aeniiae?a.
Nienie e?oa?aoo?e, ui aeei?enoiaoaaeanue, i?noeoue 342 a?o/eciyieo ?
175 caei?aeiiieo aeaea?ae.

CI?NO ?IAIOE

Iaoa??aee ? caniae aeine?aeaeaiiy. I?ae niinoa?aaeaiiyi ciaoiaeeeinue
617 oai?eo na?aaei?oyaeeith ? oyaeeith ee?i?/ieie oi?iaie ei?o, a oiio
/ene? 394 aeeoeie (63,9%) a a?oe? a?ae 6 i?n aei 14 ?ie?a ? 223
aei?ineeo (36,1%) a?eii a?ae 15 aei 35 ?ie?a, ye? ia?aaoaaee ia
e?eoaaii? a ?ioaeoe?eieo noaoe?iia?ao i. Eoaainueea oa i?no Eoaainueei?
iaeano?, a oaeiae i. Oa?eiaa, *a?ean i?ae /an niaeao?a caoai?thaaiino?
ia e??. In?a /ieia?/i? noao? aoei 358 (60%), ae?ii/i? – 259 (40%). C
o?aooaaiiyi caaaeaiue ?iaioe iaie ianoaaeaii 306 oai?eo c oneeaaeiaiei
ia?aa?aii ei?o (?en.1), a?oia ni?anoaaeaiiy aeeth/aea 311 oai?eo ia e??
c a?aenooi?noth oneeaaeiaiue.

A?iio?oe, ea?eiaio?aoa?oe, aia?ie, aioa?ieie?oe, eii’thieoea?oe ie
a?aeiineee aei oneeaaeiaiue a oiio ?ac?, eiee aiie aeieeaee a ia??iae
caanaiiy aeneio oa eaoa?aeueieo iciae, i?e iiaiio i?aeeii? oaiia?aoo?e
ia oe? ?? cieaeaiiy, aai eiee aiie i?eeiaee a?ia?a?a?/iee oa?aeoa?
(iai?eeeaae, iae?ioe/ia aia?ia, ai?eiee eii’thieoea?o, noaiicoaaeueiee
ea?eiaio?aoa?o). Ae?aaiic ei?o anoaiaaethaaany ia i?aenoaa?
aiaiianoe/ieo ai?aeai?ieia?/ieo ? ee?i?/ieo aeaieo c iaia’yceiaei
aecia/aiiyi oeo?o aioeo?e i?ioe a??ono ei?o ca aeiiiiiaith ?IAA.

?c on?o ianoaaeaieo 503 oai?eo (81,5%) aoee ?ai?oa i?euaieai? i?ioe
ei?o, o 114 (18,5%) – aaeoeeiii?io?eaeoeea ia i?iaiaeeeany. An? oai??
aoee ?iciiae?eai? ia a?eia? a?oie: ae?oe aei ?ieo, a?ae 1 ?ieo aei 3
?ie?a, a?ae 3,1 aei 6 ?ie?a, 6,1-14 ?ie?a oa a?oia aei?ineeo a?eii aei
35 ?ie?a.

?en.1 *anoioa oneeaaeiaiue o aei?ineeo ? ae?oae

Ii oa?aeoa?o i?iaaaeaiiai e?eoaaiiy on? ianoaaeai? oai?? aoee ?icae?eai?
ia aea? a?oie: iniiaio ? eiio?ieueio. Iniiaio a?oio neeaee 287 ae?oae ?
109 aei?ineeo (a oiio /ene? 176 ae?oae c na?aaeiueioyaeeei ia?aa?aii ?
111 – c oyaeeei, a oaeiae 44 oa 65 aei?ineeo a?aeiia?aeii), ye?
io?eioaaee e?eoaaiiy c aeeth/aiiyi aioeieneaeaio?a (oieioa?ieo aoeaoaoo
? anei?a?iiai? eeneioe o ae?oae oa aio?aeth – o aei?ineeo), eaoa?iio ?
oeiiaaeneio. ?aooa 107 ae?oae ? 114 aei?ineeo (na?aae yeeo 65 ae?oae ?c
na?aaeiueioyaeeei ? 42 – c oyaeeei ia?aa?aii oai?iae, a oaeiae 46 oa 68
aei?ineeo a?aeiiao?aeii) neeaee eiio?ieueio a?oio.

C iaoith aecia/aiiy aeanieo ii?i aeine?aeaeoaaieo iieaciee?a ianoaaeaii
130 aei?ineeo ?aciaeo aeiii??a e?ia? Eoaainueei? iaeanii? noaioe??
ia?aeeaaiiy, a oaeiae 117 caei?iaeo ae?oae a?eii a?ae 1 aei 14 ?ie?a,
ye? i?ioiaeeee icaei?iaeaiiy a i?io?eaeoi??yo i. Eoaainueea ?
?acoeueoaoe oanooaaiiy yeeo neeaee iniiao a?eiaeo ii?i a?io?i?/ieo oa
?ioiieia?/ieo iieaciee?a.

Ee?i?/ia niinoa?aaeaiiy ca noaiii oai?eo aeeth/aei aea/aiiy ?
?a?no?aoe?th neiioii?a oneeaaeiaiue, aiae?c oaeoi??a ?eceeo ?o oi?-

ioaaiiy, aeine?aeaeaiiy iniaeeainoae oneeaaeiaiiai ia?aa?ao,
onoaiiaeaiiy ?aii?o ianiaoeeo?/ieo ee?i?/ieo neiioii?a ?icaeoeo
oneeaaeiaiue. C iaoith ioe?iee cia/aiiy a i?iya? ei?o noaio oai?eo, yeee
ia?aaeoaaa caoai?thaaiith, aaeeeo oaaao i?eae?eyee aiaiianoe/iei aeaiei.

Aeey ae??oaiiy iinoaaeaiiai caaaeaiiy ii?yae c caaaeueiiee?i?/ieie
iaoiaeaie ianoaaeaiiy iaie canoiniaoaaeenue niaoe?aeuei? iaoiaee, ye?
aeicaieeee ioe?ieoe iaoaaie?/i? oa ?ioii? i?ioeane o i?aai?ci? oai?eo.

A?io?i?/ia aeine?aeaeaiiy i?iaiaeeeinue o aeeiai?oe? caoai?thaaiiy: i?e
iaoiaeaeaii? oa ia?aae aeieneith ?c noaoe?iia?o. Aecia/aee ??aaiue IIE
ca eiioeaio?aoe??th eiai iaoaaie?o?a – iaeiiiaiai ae?aeueaeaa?aeo
(IAeA) ? ae??iiaeo eii’thaao?a (AeE) niaeo?ioioiiao?e/ii (A.A.Aaa?eeia,
?.?. I?oei?oaeia,1983), aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie –
eaoaeace oioieaei??iao?e/iei iaoiaeii (I.A.Ei?iethe ? ni?aaao.,1988) ?
noia?ieneaeaeeniooace (NIAe) (I.I.Iaea?aae/, I.I.Aie?eia, 1983 a
iiaeeo?eaoe?? ?.?.Aeoa?i?ii? o ni?aaao.,1984). Ioe?ieo nooiaith
?ioieneeaoe?? i?iaiaeeee ii eiioeaio?aoe?? “NI” (A.A.I?eieae/ee ?
ni?aaao., 1991) Aeey oa?aeoa?enoeee nenoaie aeeicaii?ae?a aecia/aee o
ieaci? e?ia? ??aaiue o?iiaienaio OoA2 (ca noaa?eueiei iaoaaie?oii
OoA2), eiioeaio?aoe?th i?inoaaeaiaeei?a (IA) I2 (ca noaa?eueiei
iaoaaie?oii 6-eaoi-IAF1a), F2a ? A2 ?aae?i?ioiiei iaoiaeii ?c
aeei?enoaiiyi noaiaea?oieo eiia?oe?eieo iaai??a ae?iaieoeoaa ?inoeoooo
?cioii?a Oai?nueei? Aeaaeai?? Iaoe; aeine?aeaeoaaeanue eiioeaio?aoe?y
ii?i?aeieo iaioeae?a: b-aiaei?oeia, iao-aie?oae?ia oa eae-aie?oae?ia a
e?ia? ?aae?i?ioiiei iaoiaeii c aeei?enoaiiyi eiia?oe?eieo oano-iaai??a
o??ie DRG ae?iaieoeoaa NOA. Ai?no a1-oeiiceio a e?ia? aecia/aany
?aae?i?ioiiei iaoiaeii o eaai?aoi??? ?ioiia?ioaoiieia?? (caa.eaai?aoi???
i?io. A.I.Oeya?/) Iineianueeiai IAe? e?iaicai?iiee?a ? ai?iiiaeueieo
i?aia?ao?a.

?ioiiaaiaoe/i? oanoe aeeth/aee oeioaaiiy aioeaai?a nenoaie HLA eieon?a
A, A, N ? DR noaiaea?oiei aeaii?enooi/aoei i?e?ie?ioioeeoioiene/iei
iaoiaeii (?.Oerasaki et al., 1978 a iiaeeo?eaoe??
TH.I.Ca?aoeueei?,1983).

Aeey oa?aeoa?enoeee ?ioiieia?/iiai aiiainoaco aea/aee iieacieee
ee?oeiii? oa aoii?aeueii? eaiee ?ioi?oaoo ?c aecia/aiiyi e?eueeino? O-,
A-e?ioioeeo?a, O-oaeia??a/?iaeoeoi??a, O-noi?ani??a/oeeoioienee?a,
IE-ee?oei oeeoioiene/iei iaoiaeii c eiia?oe?eieie iiiieeiiaeueieie
aioeo?eaie eean?a CD3, CD4, CD8, CD22, CD16 o??ie “Ortho Diagnostic
Systems Inc” (USA) a?aeiia?aeii c iaoiaee/ieie ?aeiiaiaeaoe?yie
“Oeeoioiene/aneee iaoiae aeey ii?aaeaeaiey noa-

iiioeyoeee O- eeaoie iiiieeiiaeueiuie aioeoaeaie” i?ae ?aae.
O.I.Aaenea?a (?eaa, 1987); ooieoe?iiaeueii? aeoeaiino? NE-ee?oei
(TH.?.C?i?i ? ni?aaao., 1984); ??aiy Oe?E o ne?iaaooe? e?ia? iaoiaeii
i?aoeei?oaoe?? a 2%, 3,5%, ? 6% ?ic/eiao iie?ao?eaiae?eieth c
iieaeoey?iith ianith 6000 aeaeueoii ii Digeon et al. (1977) a
iiaeeo?eaoe?? A.I.O?ieiaa oa ni?aaao.(1986); eiioeaio?aoe??
?ioiiaeiaoe?i?a ne?iaaoee e?ia? eean?a A, I, G iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? a aae? (Mancini et al., 1965). Nainea?e?caoe?y ?ioiioeeo?a
ia?eoa?e/ii? e?ia? aei aooiaioeaai?a aea/aeanue a ?aaeoe?? ?AIE
eai?ey?iei iaoiaeii c eiiieaeniei aioeaaiii oeiono (OA), eaaai?a (EA),
e?iii?ioa?aeii ia/?iee ethaeeie (EIE) (Rosenberg and David, 1979);
oaaioeeoa?ia aeoeai?noue iiiioeeo?a (OAI) ia?eoa?e/ii? e?ia? –
/aoa/eiaei iaoiaeii (A.I.O?ieia oa ni?aaao., 1989).

*ooeea?noue A-ee?oei aei e?ea?nueeeo i?aia?ao?a ioe?ithaaeanue ca ?o
caeaoi?noth i?eeeiaoe aei neea (LAI-oano). Aeey ioe?iee noaio nenoaie
aaiinoaco aecia/aee aa?aaaoe?th, aaeaaceaio aeoeai?noue o?iiaioeeo?a o
e?ia? (A.ss. Niieyieoeueeee ? ni?aaao., 1985), cn?aeaiiy aaiicii? e?ia?
oi?o?oe??iaaiei i?e?iiaoiaeii, /an ?aeaeueoeeo?eaoe?? ieacie,
i?io?iiaeiiaee ?iaeaen ? e?euee?noue o?a??iiaaio (A.I.Aaeoaea ?
ni?aaao., 1980).

Aea/aiiy i?e?ioee?eoeyoe?? i?iaiaeeee iaoiaeii a?ii?e?ineii??
aoeueaa?ii? eii’thieoeae (AAE), yea aeiiiaithaaee ii?oiiao???th
eai?ey??a i?aoueiaiai eiaea. E?euee?nio ioe?ieo ii?ooaiue
i?e?ioee?eoeyoe?? i?iaiaeeee oeyoii a?aooaaiiy eii’thieoeaaeueieo
?iaeaen?a: noaeeiiiai – E?1, aioo??oiueinoaeeiiiai – E?2, iicanoaeeiiiai
– E?3, caaaeueiiai eii’thieoeaaeueiiai ?iaeaeno – E?0 = E?1 + E?2 + E?3
(N.A.Naeaciueia oa ni?aaao., 1995).

Iaoaiaoe/ia ia?iaea io?eiaieo aeaieo cae?enithaaeanue ia AII IBM
Pentium 200 Pci Super VGA, c aeei?enoaiiyi i?ia?aie “I?iaiic-4”,
ni?yiiaaii? ia ia?iaeo ee?i?/ii? oa eaai?aoi?ii? ?ioi?iaoe??.

Ee?i?/ia oa?aeoa?enoeea ? e?eoa??? i?iaiicoaaiiy oneeaaeiaieo oi?i ei?o.
Aeey oa?aeoa?enoeee ii??aithaaeenue ee?i?/i? iieacieee o aeaio a?oiao
oai?eo ia e?? – c iayai?noth (306 in?a) ? a?aenooi?noth (311 in?a)
oneeaaeiaiue. Oea aeicaieeei i?iaiae?coaaoe a?eia?, aiaiianoe/i?,
ia’?eoeai? oaeoi?e o oai?eo iaio a?oi, aeaye? c yeeo, ca aeaieie
e?oa?aoo?e iiaeooue aieeiooe ia ?icaeoie oa iiaeaeueoee ia?aa?a o ieo
ei?o. Aeyaeeinue, ui ieoiia aaaa oneeaaeiaiue na?aae ae?oae
aecia/a?oueny a?eii. Oae, o ae?oae ia?oiai ?ieo aeeooy /anoioa
oneeaaeiaiiai ia?aa?ao neeaea 84,8%, a oie /an ye o a?oi? oai?eo a?ae 1
aei 3 ?ie?a – 69,4%, a o ae?oae c 3 aei 6 ?ie?a ? a?ae 6 aei 14 ?ie?a –
50% ? 41,6% a?aeiia?aeii. Oaeei

/eiii, o a?oe? aei 1 ?ieo oneeaaeiaiiy cono??/aeenue a 1,2 – 2,0 ?ace
/ano?oa ii??aiyii c ae?oueie ?ioeo a?eiaeo a?oi (ia?aaaaeii iiaaiii?y,
ea?eiaio?aoa?o, aioa?eo). O ae?oae c 3 aei 6 ?ie?a iae/ano?oa
cono??/aany a?iio?o (16,2%), c 6 aei 14 – aia?ia (12,7%). O aei?ineeo
i?ney oneeaaeiaiue aeeoaeueii? nenoaie ia?aaaaeii aeieeaa noiiaoeo
(10,7%). Niieo/aiiy 2-o ? a?eueo oneeaaeiaiue o ae?oae aoei a??ia?aeii
/ano?oa, i?ae o aei?ineeo (47,6% ? 27,2% a?aeiia?aeii).

E?euee?noue oneeaaeiaieo oi?i ca?eueooaaeanue a?aeiia?aeii aei oyaeeino?
iaoieia?/iiai i?ioeano. Oae, na?aae ae?oae c oyaeeei ia?aa?aii oai?iae
oneeaaeiaiiy ?a?no?oaaeenue a 1,5 ?ace, a o aei?ineeo a 1,4 ?ace /ano?oa
i?ae c na?aaei? oyaeeei.

Iieaciai, ui /anoioa oneeaaeiaiiai ia?aa?ao ei?o aoea nooo?ai ieae/a o
ae?oae, ye? aoee ?ai?oa uaieai?. Oae oneeaaeiaiiy a a?oi? iai?euaieaieo
ae?oae, a a?oe? a?ae 1 aei 3 ?ie?a, cono??/aeenue ia 19,1% /ano?oa i?ae,
o i?euaieaieo o??? ae a?eiai? a?oie. Aiaeia?/ia ia?aaaaeaiiy
oneeaaeiaiiai ia?aa?ao ei?o (ia 23%) o iai?euaieaieo iaei i?noea ? a
a?oi? oai?eo a?eii 4 – 6 ?ie?a. Oaeei /eiii, iayai?noue a aiaiiac?
aaeoeeiii?io?eaeo?ee i?ioe ei?o ? ni?eyoeeaith i?iaiinoe/iith iciaeith a
ieai? aeaaeeiai ia?aa?ao oai?iae.

Onoaiiaeaii, ui ia ia?aa?a ei?o cia/iee aieea ia? noai, ia?aaeoth/ee
caoai?thaaiith. A a?oi? ae?oae 1-ai ?ieo aeeooy, ye? iathoue
oneeaaeiaiiy, 88,9% ciaoiaeeeinue ia ooo/iiio oa ?aiiueiio ci?oaiiio
aiaeoaaii?; a aiaiiac? iaoa??a a?eueo i?ae iieiaeie c ieo iaee i?noea
iaoieia?/iee ia?aa?a aaa?oiino? oa iieia?a (aanoic ia?oi? aai ae?oai?
iieiaeie, aiai?y, o?ii?/ia aioo??oiueioo?iaia a?iien?y, ia?aae/ani?
iieiae). Oneeaaeiaiiy ei?o a 8 ?ac?a /ano?oa cono??/aeenue o
a?iio?io?e?a, ye? no?aaeaeaee a?iiaa?oai?iicii, a?eueo i?ae a 2 ?ace o
ae?oae c aenoaeaoeaiei ae?aoacii, a 5 ?ac?a – c ?ao?oii, a 2,5 ?ace – c
aiai??th. 68,9% ae?oae c oneeaaeiaiiyie ia iiiaio caoai?thaaiiy ei?ii
aoee a ia??iae? ?aeiiaaeanoeaioe?? ?ioeie ?ioaeoe?eieie caoai?thaaiiyie
(A?A?, aia?ie, aino?? eeoeia? caoai?thaaiiy). ?icaeoeo oneeaaeiaiue
ni?eyee oaeiae noiooi? o?ii?/i? caoai?thaaiiy i?aai?a aeeoaiiy, o?ii?/ia
iaoieia?y iiniaeioee, oeoieiai-eeoeiaiai o?aeoo.

Oneeaaeiaiee ia?aa?a ei?o o aei?ineeo /ano?oa ?icaeaaany o in?a, ye?
iaee eiioaeo c i?ioan?eieie oe?aeeeainoyie (oiene/i? iiethoaioe,
caaaciaai?noue, eiio?anoi? ci?ie oaiia?aoo? oa ?i.), a oaeiae
no?aaeaeaee i?eioeiiaith e aeeiaieueiith caeaaei?noth.

Iaie aoea ?ic?iaeai? e cai?iiiiiaai? i?iaiinoe/i? oaaeeoe? iiaeeeaino?
?icaeoeo oneeaaeiaiue ei?o (oaae.1 oa 2).

?iaioa c oaaeeoeyie iieyaaea a ianooiiiio: ciaoiaeyoue

a?aeiia?aeiee ae?aaiinoe/iee eiao?oe??io aeey eiaeii? iciaee, i?ney /iai
an? eiao?oe??ioe i?aenoiiaothoue. sseui noia ia?aaeuo? /eneiaee ii??a
+17 aeey ae?oae, +25 aeey aei?ineeo ? a?eueoa, oi ?iaeoueny aeniiaie, ui
e?? i?eeia oneeaaeiaiee oa?aeoa?.

Oaaeeoey 1

Oaeoi?e, ui ni?eythoue ?icaeoeo oneeaaeiaiue o ae?oae oai?eo ia e??

Ae?oe (n=394)

Oaeoi?e ?eceeo

E?euee?noue aae?a

Iayai?noue

oaeoi?a

A?aenooi?noue

oaeoi?a

O?ii?/i? ?iceaaee oa?/oaaiiy

+8,0

-1,0

?ao?o ??-??? nooiaith

+6,0

-0,5

Aiai?y ??-??? nooiaith

+3,5

-0,5

Aea?a?/i? caoai?thaaiiy

+3,0

-0,5

Aioa?ia?ic

+2,5

-0,5

Ia??iae ?aeiiaaeanoeaioe?? ?ioaeoe?eieie oai?iaaie

+5,0

-1,0

O?ii?/ia iaoieia?y iiniaeioee

+4,0

-0,5

Iiaoi?i? ?ani??aoi?i? caoai?thaaiiy

+6,0

-1,0

Iani?eyoeea? iaoa??aeueii-iiaooia? oiiae

+3,5

-0,5

Caoai?thaaiiy aeeoaeueii? nenoaie

+6,0

-0,5

A?aenooi?noue aaeoeeiaoe??

+5,0

-5,0

Oyaeeee ia?aa?a oai?iae

+3,0

-2,0

A?e aei 3-o ?ie?a

+4,5

-1,5

Iaeneiaeueia noia aae?a

+60,0

-15,0

Oaaeeoey2

Oaeoi?e, ui ni?eythoue ?icaeoeo oneeaaeiaiue o aei?ineeo oai?eo ia e??

Aei?ine? (n=223)

Oaeoi?e ?eceeo

E?euee?noue aae?a

Iayai?noue oaeoi?a

A?aenooi?noue oaeoi?a

O?ii?/i? ?iceaaee o?aaiaaiai o?aeoo

+4,5

-0,5

Aiai?y ??-??? nooiaith

+3,5

-1,0

Aea?a?/i? caoai?thaaiiy

+2,5

-0,5

Iani?eyoeea? iaoa??aeueii-iiaooia? oiiae

+5,0

-1,0

O?ii?/ia iaoieia?y iiniaeioee

+9,0

-1,5

Iiaoi?i? ?ani??aoi?i? caoai?thaaiiy

+7,0

-1,0

Ia??iae ?aeiiaaeanoeaioe?? ?ioaeoe?eieie oai?iaaie

+9,5

-2,5

Ceiaaeeaaiiy aeeiaieai

+7,5

-0,5

Othothiiaa caeaaei?noue

+8,0

-3,0

I?ioan?ei? oe?aeeeaino?

+8,5

-0,5

Caoai?thaaiiy aeeoaeueii? nenoaie

+8,5

-0,5

Oyaeeee ia?aa?a oai?iae

+0,5

-1,0

Iaeneiaeueia noia aae?a

+74,0

-13,5

?ioii? oa ?ioiiaaiaoe/i? iieacieee o oai?eo c ??ciei ia?aa?aii ei?o .

A aino?iio ia??iae? ei?o caaaeueia ni?yiiaai?noue ci?i iieaciee?a
?ioi?oaoo oa?aeoa?ecoaaeanue i?eai?/aiiyi O-ee?oeiii? eaiee, ui
i?iyaeyeinue cieaeaiiyi e?eueeino?, ye caaaeueii? e?eueeino? ND3, oae ?
noaiiioeyoe?? ND4-e?ioioeeo?a (oaae.3). A?aeiinia ia?aaaaeaiiy
O-noi?ani??a/oeeoinoaoee?a i?eaiaeeei aei cieaeaiiy ?ioii?aaoeyoi?iiai
?iaeaeno ND4/ND8 ? noi?iaiaeaeoaaeiny iiaeeaeaiiyi aeai?an?? O-nenoaie.

Oaaeeoey 3a

Iieacieee ?ioi?oaoo o oai?eo na?aaeiueioyaeeith oi?iith ei?o

Iieacieee

A?e ianoaaeaieo (?iee)

1-3

3,1 – 6

6,1 – 14

aei?ine?

Ia?aa?a oai?iae

iaoneeaaeiaiee

oneeaaeiaiee

iaoneeaaeiaiee

oneeaaeiaiee

iaoneeaaeiaiee

oneeaaeiaiee

iaoneeaaeiaiee

oneeaaeiaiee

Na?aaeiueioyaeea oi?ia (M±m)

CD3,*109/e

CD4,*109/e

CD8,*109/e

CD4/ CD8

CD22,*109/e

CD16,*109/e

?Oe IE, %

Oe?E a/e

Aaeee., a/e

Na?aae., a/e

Ae??ai., a/e

?AIE c OA

O?

O*

2,2±0,1

1,2±0,04

0,97±0,04

1,23±0,07

0,83±0,025

0,2±0,01

20,5±1,4

2,41±0.25

0,95±0,01

0,9±0,4

0,54±0,4

0,89±0,05

19,3±1,7

2,1±0,2

(n=22)

1,7±0,08***

0,8±0,03***

0,86±0,035*

0,94±0,06***

0,77±0,01*

0,17±0,01*

15,7±1,2**

3,22±0.3*

1,0±0,02*

1,36±0,8*

0,86±0,5*

0,77±0,03*

14,6±1,4*

1,6±0,12*

(n=29)

2,0±0,1

1,0±0,04

0,92±0,04

1,1±0,05

0,58±0,03

0,26±0,012

22,4±1,4

3,2±0.15

1,2±0,07

1,2±0,06

0,8±0,04

0,85±0,03

17,3±1,6

1,9±0,12

(n=53)

1,7±0,08**

0,79±0,03***

0,83±0,03*

0,96±0,04

0,46±0,023***

0,22±0,011**

17,5±0,9**

3,7±0,19*

1,0±0,05*

1,7±0,09***

1,0±0,05**

0,76±0,03*

12,0±1,2**

1,4±0,1***

(n=50)

1,5±0,08

0,78±0,04

0,6±0,05

1,3±0,06

0,4±0,02

0,28±0,01

35,4±1,8

3,9±0,15

1,36±0,04

1,5±0,08

1,04±0,05

0,76±0,02

19,4±1,0

2,6±0,15

(n=84)

1,3±0,06*

0,58±0.03***

0,6±0.033

0,98±0.04***

0,34±0,017*

0,24±0,009**

26,7±1,3***

4,5±0,2**

1,25±0,03*

1,92±0,1***

1,33±0,07***

0,7±0,02*

15,0±0,8***

2,0±0,1***

(n=54)

1,2±0,1

0,63±0,04

0,45±0,02

1,4±0,1

0,34±0,017

0,29±0,009

32,5±2,0

3,6±0,12

1,26±0,06

1,4±0,07

0,94±0,05

0,82±0,035

19,4±1,0

2,1±0,1

(n=53)

0,9±0,06**

0,44±0,02***

0,4±0,01*

1,1±0,05**

0,21±0,013***

0,25±0,09***

23,0±1,4***

4,2±0,2**

1,05±0,06**

2,0±0,1***

1,15±0,053**

0,73±0,03*

14,1±0,71***

1,6±0,09***

(n=53)

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