IAOEIAI-AeINE?AeIEE ?INOEOOO

AI?AeAI?IEIA?? OA ?IOAEOe?EIEO OAI?IA

?iai? E.A.A?IIAOAANUeEIAI

??OIAA ??EIA AI?EN?AIA

OAeE 616.915-06-08.001.18

I?IAIICOAAIIss, I?IO?EAEOEEA OA E?EOAAIIss ONEEAAeIAIEO OI?I EI?O

14.01.13 – ?ioaeoe?ei? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

Iaoeia? eiinoeueoaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? O?ieia Aaea??e Ieo?ioaiiae/,
Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa. eaoaae?e
?ioaeoe?eieo oai?ia oa ai?aeai?ieia??

caneoaeaiee ae?y/ iaoee Oe?a?ie, eao?aao Aea?aeaaii? i?ai?? Oe?a?ie,
aeieoi? iaaee/ieo iaoe, i?ioani? A?iiaoaanueea Ethaia Eaiio??aia,
EIAe?A?O ?i. E.A. A?iiaoaanueeiai, caa?aeoth/a eaai?aoi??? ee?i?/ii?
a?io?i??

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Iinothe Aaiaoa ?aai?aia, EAeIO,
caa.eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia,

aeieoi? iaaee/ieo iaoe, i?ioani? O??oeiaa E?y Ieaen??aia, Iaoe?iiaeueiee
iaaee/iee oi?aa?neoao ?i.aeaae. I.I.Aiaiiieueoey IIC Oe?a?ie, i?ioani?
eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia,

aeieoi? iaaee/ieo iaoe, i?ioani? Eeieai Aai?a?e Ieeiea?ae/ Ee?anueea
iaaee/ia aeaaeai?y i?neyaeaieiiii? ina?oe ?i. I.E.Ooi?ea, caa. eaoaae?e
ee?i?/ii? eaai?aoi?ii? ae?aaiinoeee

I?ia?aeia onoaiiaa: Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC
Oe?a?ie

Caoeno a?aeaoaeaoueny “21”/a?aiy 1999 ?ieo ia10 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae .26.614.01 i?e Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?iai? E.A.A?iiaoaanueeiai IIC Oe?a?ie ca aae?anith: 252150, i.Ee?a,
aoe.N?/iaaiai iianoaiiy, 23

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? EIAe?A?O IIC Oe?a?ie
(252150, i.Ee?a, aoe.N?/iaaiai iianoaiiy, 23)

Aaoi?aoa?ao ?ic?neaiee “20”o?aaiy1999?ieo

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe,
___________ A.Ae.Aiae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

E??, iacaaaeath/e ia i?iaaaeaiiy oe?iei? i?ia?aie ?ioi?caoe??, aei
inoaiiueiai /ano caeeoa?oueny iaei??th c iaea?eueo ?iciianthaeaeaieo
aeeoy/eo e?aiaeueieo ?ioaeoe?e. Ca aeaieie AIC caoai?thaai?noue ia e??
ui??/ii neeaaea? a?ey 70 iei /ieia?e e yaey? cia/io caa?ico aeey
caei?ia’y oa aeeooy ye ae?oae, oae ? aei?ineiai ianaeaiiy. E?? cia/ii
iineaaeth? ?ioiio nenoaio i?aai?cio ? a?aee?eaa? oeyo aei ?ioeo aino?eo
? o?ii?/ieo ?ioaeoe?e. Onoaiiaeaii, ui ?aeeiith i?e/eiith nia?oiino?
a?ae ei?o noathoue eiai oneeaaeiaiiy (E.A.Aeno?yeiaa, 1992). Iaciaiiy
iaoiaaiaco ?o oi?ioaaiiy i?e??aith?oueny aei iaciaiiy naii? oai?iae.

Aeooaeuei?noue oaie. Uaieaiiy i?ioe ei?o a iaeaeeae/? ?iee ia ae??oeoue
on?o i?iaeai oe??? ?ioaeoe??, ai ca aeaieie io?oe?aeueii? noaoenoeee o
15-20% ae?oae aioeo?ea i?ioe ei?o ia ae?iaeythoueny (E.I.*oaeia, 1997).
E?euee?noue oaeeo ae?oae ii e?a?i? neeaaea? a?ey 1,5 iei., ui noa?
iniiaith aeey ai?aeai?/iiai i?ioeano. Ia aeeaey/enue ia iioe?aiiy
e?eoaaeueieo iiaeeeainoae, ca inoaii? 10 ?ie?a oneeaaeiaiiy ei?o ia
iathoue oaiaeaioe?th aei cieaeaiiy ? i?aaenoaaeythoue ?aaeueio caa?ico
aeey aeeooy. Ioaea, aeioe?eueii aea/eoe iaoiaaiaoe/i? iniaeeaino?
?icaeoeo oa i?iaiicoaaiiy oneeaaeiaieo ? oyaeeeo oi?i oai?iae, ui
aeicaieeoue aeei?enoaoe io?eiai? aeai? aeey iiooeo a?eueo aoaeoeaieo
cania?a i?io?eaeoeee ? e?eoaaiiy.

Ca inoaii? ?iee iniaeeao oaaao aeine?aeiee?a i?eaa?oathoue ci?ie
iieaciee?a iaoaaie?/iiai aiiainoaco i?e ??cieo iaoieia?/ieo noaiao.
I?aeaeuai? eiioeaio?aoe?? i?e?iaeieo iaoaaie?o?a, i?ii?aeieo ?
e?ioeaaeo ?a/iaei ?o iai?io iiaeooue i?iyaeyoe oiene/io ae?th ia
i?aai?ci ethaeeie, aeeeeeath/e noai “iaoaaie?/ii? ?ioieneeaoe??” (E.E.
A?iiaoaanueea, 1990, 1996, 1997). Aeine?aeaeaiiy a oeueiio iai?yieo
aeathoue iiaeeeaino? c’ynoaaiiy cia/aiiy o oi?ioaaii? iani?eyoeeaiai
ia?aa?ao oai?iae i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a (IIE),
iaoaaie?cio aeeicaii?ae?a, iae?iiaioeae?a, ai?iii?a aeei/eiai? caeice e
nenoaie aaiinoaco.

Oa?aeoa?, /anoioa oneeaaeiaiue oa nia?oi?noue a?ae ei?o a cia/i?e i???
caeaaeeoue a?ae noaio ?ioiii? nenoaie (A.I.O?ieia oa ni?aaao., 1991,
1994). I?e oeueiio aaeeea ?ieue a oi?ioaaii? ?ioiiiai aeao?oeeoo
iaeaaeeoue nenoai? HLA, yea o?nii iia’ycaia c aaiaie ?ioiii? a?aeiia?ae?
(A.I.Ae?aii?e, oa ni?aaao.1990).

Iniaeeao oaaao i?eaa?oathoue aeai?, i?aaenoaaeai? niaoe?ae?noaie
Ee?anueeiai IAeO ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i.E.A.A?iiaoaanueeiai, noiniaii i?eai?/oth/iai aieeao aeieia?/ieo
caa?oaeiaiue ia ??aaiue

?ioi?oaoo ae?oae oa aei?ineeo a aeieia?/ii iani?eyoeeaeo ?aa?iiao
(E.I.*oaeia oa ni?aaao., 1993; TH.A. Aa?ooaei, 1997).

Aaaeeeaa ?ieue o oi?ioaaii? ?ioiiaeao?oeeoieo noai?a a?aeaiaeeoueny
iaaeinoaoiino? aioo??oiueinae?aoi?ii? ooieoe?? aeei/eiai? caeice —
oeaio?aeueiiai i?aaio ?ioiii? nenoaie. ?ai?oa aoee io?eiai? aeai? i?i
aaciina?aaei?e aieea ai?iii?a oeiono, cie?aia, oeiiceio, ia
iae?iaiaeie?eii? ooieoe?? i?aai?cio (G. Millington, J.C. Buckingham,
1992; A.A.ss?ee?i, 1998). Ia iao iiaeyae ia?niaeoeaiei aoei a aea/aiiy
iniaeeainoae iaoiaaiaco ei?o e ?icaeoie eiai oneeaaeiaieo oi?i
iaoiaeaie ?ioiia?io?i??, ? cie?aia aea/eoe aca?iica’ycie i?ae
iaae?aoi?aie ?ioiii?, iae?iaiaeie?eiii? nenoai, a oaeiae iae?iiaioeaei?
iaoai?cie ?aaoeyoe?? ?ioi?oaoo.

Ia iaio cia/iei aniaeoii o ae??oaii? i?iaeaie ei?iai? ?ioaeoe?? ? iiooe
iiaeo aoaeoeaieo cania?a, caeaoieo caaacia/eoe iioeiaeueiee ?icaeoie
i?ioean?a naiiaaiaco e caiia?aoe iani?eyoeeaiio ia?aa?ao ? caaa?oaiith
oai?iae.

Caeaoi?noue a??ono ei?o aeeeeeaoe noai aia?a?? iio?aao? iaia’yceiaiai
aeei?enoaiiy a eiiieaeni?e iaaeeeaiaioici?e oa?ai?? i?aia?ao?a
?ioiio?iiii? ae??. ?ai?oa aoei iaa?oioiaaii iaoiaaiaoe/ia aeei?enoaiiy
i?e oyaeeeo oi?iao ei?o nieai?io, ioeea?iaoo iao??th, ?iaeoeoi?a neioaco
aiaeiaaiiiai ?ioa?oa?iio – iaoaiai?iiai? eeneioe, oieioa?ieo aoeaoaoo
(O.?.??oia, 1989; ?.I.Iicaeiyeiaa, 1992). Iaeiae aeei?enoaiiy oeacaieo
i?aia?ao?a o eiiieaeni?e oa?ai?? ei?o ia caaaeaee i?eiineei i/?eoaai?
?acoeueoaoe. Oiio aaeee? niiae?aaiiy iieeaaeathoueny ia
aeeoa?aioe?eiaaia aeei?enoaiiy iiaeo eiia?iaoe?e i?aia?ao?a, ae?y yeeo
aoea a ni?yiiaaia ia ??ci? eaiee iaoiaaiaco ei?o, c o?aooaaiiyi a?eo
oai?eo, oyaeeino? i?ioeano, iayaiino? oneeaaeiaiue.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

?iaioa aeeiioaaeanue ca?aeii ieaio IAe? Eoaainueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo a ?aieao aaeocaai? i?ia?aie a iaeano?
iaaeeoeeie N. 14 “Aea/aiiy iaoeiaeo ? i?aai?caoe?eieo aniaeo?a
cieaeaiiy caoai?thaaiino? ianaeaiiy ?ioaeoe?eieie oai?iaaie ?
e?ea?aeaoe?? ea?iaaieo ?ioaeoe?e” ca oaiith IAe? eaoaae?e aeeoy/eo
oai?ia “Ee?i?ei-?ioiieia?/i? iniaeeaino? ei?o, i?iaiicoaaiiy iane?aee?a
a oiiaao i?iieneiaiai ?aa?iio” (? aea?ae?a?no?aoe?? 01900011624).

Iaoa aeine?aeaeaiiy: ?ic?iaea e?eoa???a i?iaiicoaaiiy oneeaaeiaiue i?e
ei?o, ?aoe?iiaeueieo i?eioeei?a ?o i?io?eaeoeee oa ei?aeoe?? aeyaeaieo
ii?ooaiue ia i?aenoaa? no/aniiai eiiieaeniiai aeine?aeaeaiiy ee?i?/ieo,
aaiaoe/ieo, ?ioiieo, a?io?i?/ieo oa i?e?ioee?eoeyoi?ieo iniaeeainoae
iaoieia?/iiai i?ioeano.

A?aeiia?aeii aei oeacaii? iaoe aeine?aeaeaiiy aoee iinoaaeai? oae?
eiie?aoi? caaaeaiiy:

1. I?iaiae?coaaoe oa?aeoa? ? /anoioo ?icaeoeo oneeaaeiaiue o ae?oae ?
aei?ineeo oai?eo ia e?? c o?aooaaiiyi oyaeeino?, ia?aa?ao oai?iae, a?eo
oai?eo.

2. Aea/eoe cia/aiiy noaio oai?eo ia e??, yeee ia?aaeoaaa caoai?thaaiith
a ieai? ?iia??iino? ?icaeoeo oneeaaeiaiue.

3. Aeyaeoe iiaeeeao cia/ei?noue ?ioii-aaiaoe/ieo iieaciee?a a
i?aeaeuaii? nooiaith ?eceeo aeieeiaiiy oneeaaeiaiue.

4. Aea/eoe ai?no a1-oeiiceio (ai?iiio aeei/eiai? caeice) o oai?eo ia e??
oa eiai aca?iia?aeiioaiiy c ?ioiieia?/ieie iieacieeaie i?e iayaiino? ?
a?aenooiino? oneeaaeiaiue.

5. Aeine?aeeoe ?ioaineai?noue i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a
(IIE), aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie, ??aaiue ai?noo
aeeicaii?ae?a ? “na?aaei?o iieaeoe” “NI” a iaoiaaiac? neiae?iio
“iaoaaie?/ii? ?ioieneeaoe??” i?e ?icaeoeo oneeaaeiaiue.

6. Aeyaeoe caeiiii??iino? ci?i aiaeiaaiieo ii?i?aeieo iaioeae?a
(b-aiaei?o?io, iao?ii?i- ? eaeoeeo?i-aie?oae?io) o oai?eo ??cieie
oi?iaie ei?o, ?o aieea ia ?ioii? ? iaoaaie?/i? i?ioeane.

7. Aeine?aeeoe noai nenoaie i?e?ioee?eoeyoe??, aaiinoaco, ?o
aca?iiiaoiiaeai?noue c ?ioiieie ? iaoaaie?/ieie i?ioeanaie i?e
oneeaaeiaieo oi?iao ei?o.

8. Ia i?aenoaa? io?eiaieo aeaieo aeae?eeoe iaea?eueo ?ioi?iaoeai?
e?eoa???, ye? iathoue cia/ei?noue a i?iaiicoaaii? aeieeiaiiy
oneeaaeiaiue o oai?eo ia e??; iaa?oiooaaoe i?eioeeie ? eiie?aoi? niiniae
e?eoaaiiy a?oi ?eceeo ii ?icaeoeo oneeaaeiaiue.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. I?iaaaeaia eiiieaenia
aeine?aeaeaiiy c aeei?enoaiiyi ee?i?/ieo, a?io?i?/ieo, ?ioii-aaiaoe/ieo
iaoiae?a aeicaieeei ?icoe?eoe ? iiaeeaeoe oyao i?i iaoiaaiaoe/i?
iaoai?cie, ye? eaaeaoue a iniia? oneeaaeiaieo oi?i ei?o.

Aecia/aia ?ieue noaio i?aai?cio ia oii? yeiai ?icaeioeinue
caoai?thaaiiy, a?eo oai?eo oa iniaeeainoae ee?i?/iiai ia?aa?ao ei?o a
?icaeoeo oneeaaeiaiue.

Iieacaii cia/aiiy iayaiino? aioeaai?a HLA, oi?ioaaiiy o oai?eo ia e??
aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? o iaoiaaiac? oyaeeiai ?
oneeaaeiaiiai ia?aa?ao oai?iae. I?e oeueiio aia?oa aeyaeaia
iaaeinoaoi?noue ??aiy a1 — oeiiceio, ni?eyth/a oi?ioaaiith aoi?eiiiai
?ioiiaeao?oeeoiiai noaio o oai?eo ia e?? i?e oneeaaeiaiiio eiai
ia?aa?ao.

Onoaiiaeai? caeiiii??i? ci?ie iieaciee?a IIE, aeoeaiino? aioeia?aeenii?
nenoaie. Iieacaii, ui nooi?iue ae?aco ci?i aecia/a?oueny

oyaee?noth oai?iae ? iayai?noth oneeaaeiaiue. I?e ??cieo oi?iao ei?o
?niothoue ei?aeyoe?ei? ca’ycee i?ae IIE ? ?ioiieie iieacieeaie.

Aecia/ai? iniaeeaino? ci?i IA, ye? iathoue cia/aiiy o oi?ioaaii?
oneeaaeiaiue i?e ei?o.

Aeyaeaia ii?i?aeia aeoeai?noue e?ia? i?e ??ciiio ia?aa?ao ei?o.

Onoaiiaeai? iniaeeaino? aaiinoaco, i?e?ioee?eoeyoe?? i?e oneeaaeiaieo
oi?iao ei?o oa ?o aca?iica’ycie c ?ioiieie e iaoaaie?/ieie iieacieeaie.

?ic?iaeai?, iaoiaaiaoe/ii iaa?oioiaai?, e?eoa??? i?iaiicoaaiiy ?
oa?aiaaoe/i? caoiaee, ni?yiiaai? ia caiia?aaiiy ?icaeoeo oa e?eoaaiiy
oneeaaeiaieo ? oyaeeeo oi?i ei?o.

I?aeoe/ia cia/ei?noue io?eiaieo ?acoeueoao?a. Ia i?aenoaa? ee?i?/ieo,
iaoaaie?/ieo, ?ioiieo iieaciee?a aoa cai?iiiiiaaiee eiiieaen e?eoa???a
i?iaiicoaaiiy ?icaeoeo oneeaaeiaieo oi?i ei?o.

«A?oiith ?eceeo» ?icaeoeo oneeaaeiaiue ?aeiiaiaeo?oueny aaaaeaoe oai?eo
ia e??, o aiaiiac? yeeo iathoue i?noea iani?eyoeeaee noai, yeee
ia?aaeoaaa oai?ia? (o?ii?/i? ?iceaaee o?aaiaaiai o?aeoo, aa?oai?iice,
caoai?thaaiiy iiniaeioee, aeeoaeueii? nenoaie, ia??iae
?aeiiaaeanoeaioe?? ?ioeie ?ioaeoe?eieie oai?iaaie, iiaoi?i? ?ani??aoi?i?
?ioaeoe??), a?aenooi?noue aaeoeeiiuaieaiiy, a?e aei 3 ?ie?a.

Iayai?noue o oaiioei? aioeaai?a nenoaie HLA-A2, A7, A13, Bw35, DR2, ?
a?aenooi?noue aioeaai?a A1, A11, A8 i?eionea? oyaeeee ? oneeaaeiaiee
ia?aa?a ei?o.

Cieaeaiiy ??aiy CD3 — e?ioioeeo?a aei 35% a?eiai? ii?ie o ae?oae ? 40% o
aei?ineeo, ni?aa?aeiioaiiy CD4/CD8 aei 1,3 ? 1,0, i?aeaeuaiiy
eiioeaio?aoe?? Oe?E a?eueoa 3,2 a/e ? 4,5a/e, i?aeaeuaiiy ?AIE aei OA
aei 0,9 ? 0,6 ? iani?eyoeeaeie ?ioiieia?/ieie iciaeaie oi?ioaaiiy
oneeaaeiaiue ? oyaeeiai ia?aa?ao oai?iae.

I?e ai?no? IAeA aei 41,5 ieiieue/e e 61,0 ieiieue/e ? aeua o ae?oae oa
aei?ineeo a?aeiia?aeii, cieaeaii? ni?aa?aeiioaiiy 6-eaoi-IAF1a/OoA2 aei
0,7 ? 1,0, i?aeaeuaii? ni?aa?aeiioaiiy IAF2a/IAA2 aei 3,0 ? 3,5,
ciaioaii? ai?noo a1-oeiiceio aei 1,0 ia/ie ? 0,4 ia/ie, iiaeia
ia?aaeaa/eoe oyaeeee ia?aa?a ei?o c oneeaaeiaiiyie.

Ca aeiiiiiaith ?aa?an?iiiiai aiae?co aoei ?ic?aoiaaii ii??aiyiiy
?aa?an?? ca aeiiiiiaith yeiai ii e?eueeino? CD4 e?ioioeeo?a iiaeeeai
iina?aaeiuei noaeeoe i?i ai?no a1-oeiiceio (a1-oeiicei = — 0,3524 +
0,03837 • CD4).

Cai?iiiiiaai? iaoiaaiaoe/ii iaa?oioiaai? i?aeoiaee aei e?eoaaiiy oa
iiia?aaeaeaiiy ?icaeoeo oyaeeeo oa oneeaaeiaieo oi?i ei?o ?c
canoinoaaiiyi aioeieneaeaio?a (oieioa?ieo aoeaoaoo ? anei?a?iiai?
eeneioe

o ae?oae ? aio?aeth o aei?ineeo), oa i?e cieaeaii? ai?iiiaeueii?
ooieoe?? oeiono – i?aia?ao?a ?ioiiiiaeoethth/i? ae?? (oeiiaaeneio).

Ao?eaiiy a i?aeoeeo io?eiaieo ?acoeueoao?a. ?acoeueoaoe i?iaaaeaieo
aeine?aeaeaiue ? ee?i?/ieo niinoa?aaeaiue ai?iaaaeaeai? a i?aeoeeo
?iaioe e?eoaaeueieo caeeaae?a Eoaainueei?, Euea?anueei?, Aeiiaoeueei?,
Oa?e?anueei?, *a?eanueei?, *a?i?aaoeueei? iaeanoae Oe?a?ie. Iaea?aeai?
iia? aeai? aeeth/ai? aei iaa/aeueiiai i?ioeano 5 iaaee/ieo AIC?a oa
?inoeooo?a oaeineiiaeaiiy e?ea??a Oe?a?ie. Iniiai? ?acoeueoaoe
aeine?aeaeaiiy aeeeaaeai? a iiiia?ao?? «Ei?ue (eeeieea e iaoiaaiac)», a
oaeiae aeeth/ai? o 2 iaoiaee/i? ?aeiiaiaeaoe?? aeey e?ea??a oa
noai?aeeiaoi??a ii ae?aaiinoeoe? oa e?eoaaiith oneeaaeiaieo oi?i ei?o.

Iniaenoee aianie aaoi?a. Ianoaaeaii 617 oai?eo ia e?? c?
na?aaeiueioyaeeei ? oyaeeei ia?aa?aii; — aeeiiaia ia?aaaaeia /anoeia
aeine?aeaeaiue o aea/aii? iaoaaie?/ieo oa ?ioiieo iniaeeainoae
iaoieia?/iiai i?ioeano o ianoaaeaieo oai?eo; o /anoeie oai?eo o
aeeiai?oe? oai?iae aaciina?aaeiuei i?iaaaeaii ianoaaeaiiy
i?e?ioee?eoeyoe??.

?ic?iaeaia oa ee?i?/ii aei?iaoaaia eiia?iiaaia oa?ai?y oneeaaeiaieo oi?i
ei?o c aeei?enoaiiyi aioeieneaeaioieo oa ?ioiio?iiieo cania?a, aeaia
ioe?iea aoaeoeaiino? cai?iiiiiaaiiai e?eoaaiiy; i?iaaaeaia noaoenoe/ia
ia?iaea io?eiaieo aeaieo ca aeiiiiiaith AII.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue oa iaaiai?thaaeenue ia ?aa?iiaeuei?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeeyiea oaeoi?ia aiaoiae n?aaeu ia
?aaeoeaiinoue i?aaiecia” (Ee?a-Ai?ioeeiaa?aae, 1990), 4-e
i?ae?aa?iia?i?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeueiua i?iaeaiu
eioaeoeeiiiie iaoieiaee, eeeie/aneie eiioiieiaee e iaaeeoeeineie
aaiaoeee” (Iineaa-Eoaainuee,1991), i?ae?aa?iiaeuei?e iaoeia?e
eiioa?aioe?? ?ioiieia?a, ?ioaeoe?ii?no?a, aaiaoee?a, aea?aieia?a
(Iineaa-Eoaainuee, 1992), ?aa?iiaeuei?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Yeieiaey Aeiiaanna” (Eoaainuee, 1993), ia ?anioae?eainueeiio nai?ia??
“Aeieia?y, ?ioi?oao oa caei?ia’y ianaeaiiy” (Ee?a-Eoaainuee, 1994), II
iaoeiaiio neiiic?oi? “Aeooaeuei? i?iaeaie aeieia?/ii? oa ee?i?/ii?
?ioiieia??” (Ee?a-Eoaainuee,1994), III iaoeiaiio neiiic?oi? “Aeooaeuei?
i?iaeaie aeieia??, ee?i?/ii? ?ioiieia?? oa ?ioaeoe?eii? iaoieia??”
(Ee?a-Eoaainuee, 1995), tha?eaei?e iaoeiai-i?aeoe/i?e eiioa?aioe??,
i?enay/ai?e 100-??//th 4-? i?nueei? e?ea?i? i.Eoaainueea
(Eoaainuee,1995), iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 35-??//th
eaoaae?e nioe?aeueii? iaaeeoeeie, i?aai?caoe?? oa aeiiii?ee ioi?iie
caei?ia’y “Caei?iauea ianaeaiey: nioeeaeueii-yeiiiie/aneea aniaeou,
i?aaiecaoeey iaaeeoeeineiai

ianeoaeeaaiey” (Eoaainuee, 1995), ni?euei?e iaoeia?e nan??
“Ineoiniiaoe/aneea ?ano?ienoaa” (Oa?e?a-Eoaainuee,1995), XIII c’?cae?
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a oa
ia?aceoieia?a ?i. Ae.E.Caaieioiiai (Ee?a-A?iieoey, 1996), iaeanieo ?
?aa?iiaeueieo eiioa?aioe?yo, nai?ia?ao ? can?aeaiiyo iaoeiai-i?aeoe/ieo
oiaa?enoa ?ioaeoe?ii?no?a, iaae?ao??a, a?io?i?e?a, ?ioiieia?a (E?aniee
Eo/, 1993; E?n?/ainuee, 1995; Eoaainuee, 1994-1997).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 44 ?iaioe a oiio /ene?
1 iiiia?ao?y, 22 iaoeia? ?iaioe o i?io?eueieo iaaee/ieo aeaeaiiyo, 19
oac eiioa?aioe?e, 2 iaoiaee/i? ?ic?iaee.

No?oeoo?a oa ianya aeena?oaoe??. ?iaioa aeeeaaeaia ia 311 noi??ieao
iaoeiiieno, aeeth/a? 8 aeienie ?c ?noi??e oai?iae. Aeena?oaoe?y
neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, iieno iaoa??ae?a oa
iaoiae?a aeine?aeaeaiiy, 5 ?icae?e?a aeanieo aeine?aeaeaiue, aeniiae?a.
Nienie e?oa?aoo?e, ui aeei?enoiaoaaeanue, i?noeoue 342 a?o/eciyieo ?
175 caei?aeiiieo aeaea?ae.

CI?NO ?IAIOE

Iaoa??aee ? caniae aeine?aeaeaiiy. I?ae niinoa?aaeaiiyi ciaoiaeeeinue
617 oai?eo na?aaei?oyaeeith ? oyaeeith ee?i?/ieie oi?iaie ei?o, a oiio
/ene? 394 aeeoeie (63,9%) a a?oe? a?ae 6 i?n aei 14 ?ie?a ? 223
aei?ineeo (36,1%) a?eii a?ae 15 aei 35 ?ie?a, ye? ia?aaoaaee ia
e?eoaaii? a ?ioaeoe?eieo noaoe?iia?ao i. Eoaainueea oa i?no Eoaainueei?
iaeano?, a oaeiae i. Oa?eiaa, *a?ean i?ae /an niaeao?a caoai?thaaiino?
ia e??. In?a /ieia?/i? noao? aoei 358 (60%), ae?ii/i? — 259 (40%). C
o?aooaaiiyi caaaeaiue ?iaioe iaie ianoaaeaii 306 oai?eo c oneeaaeiaiei
ia?aa?aii ei?o (?en.1), a?oia ni?anoaaeaiiy aeeth/aea 311 oai?eo ia e??
c a?aenooi?noth oneeaaeiaiue.

A?iio?oe, ea?eiaio?aoa?oe, aia?ie, aioa?ieie?oe, eii’thieoea?oe ie
a?aeiineee aei oneeaaeiaiue a oiio ?ac?, eiee aiie aeieeaee a ia??iae
caanaiiy aeneio oa eaoa?aeueieo iciae, i?e iiaiio i?aeeii? oaiia?aoo?e
ia oe? ?? cieaeaiiy, aai eiee aiie i?eeiaee a?ia?a?a?/iee oa?aeoa?
(iai?eeeaae, iae?ioe/ia aia?ia, ai?eiee eii’thieoea?o, noaiicoaaeueiee
ea?eiaio?aoa?o). Ae?aaiic ei?o anoaiaaethaaany ia i?aenoaa?
aiaiianoe/ieo ai?aeai?ieia?/ieo ? ee?i?/ieo aeaieo c iaia’yceiaei
aecia/aiiyi oeo?o aioeo?e i?ioe a??ono ei?o ca aeiiiiiaith ?IAA.

?c on?o ianoaaeaieo 503 oai?eo (81,5%) aoee ?ai?oa i?euaieai? i?ioe
ei?o, o 114 (18,5%) — aaeoeeiii?io?eaeoeea ia i?iaiaeeeany. An? oai??
aoee ?iciiae?eai? ia a?eia? a?oie: ae?oe aei ?ieo, a?ae 1 ?ieo aei 3
?ie?a, a?ae 3,1 aei 6 ?ie?a, 6,1-14 ?ie?a oa a?oia aei?ineeo a?eii aei
35 ?ie?a.

?en.1 *anoioa oneeaaeiaiue o aei?ineeo ? ae?oae

Ii oa?aeoa?o i?iaaaeaiiai e?eoaaiiy on? ianoaaeai? oai?? aoee ?icae?eai?
ia aea? a?oie: iniiaio ? eiio?ieueio. Iniiaio a?oio neeaee 287 ae?oae ?
109 aei?ineeo (a oiio /ene? 176 ae?oae c na?aaeiueioyaeeei ia?aa?aii ?
111 – c oyaeeei, a oaeiae 44 oa 65 aei?ineeo a?aeiia?aeii), ye?
io?eioaaee e?eoaaiiy c aeeth/aiiyi aioeieneaeaio?a (oieioa?ieo aoeaoaoo
? anei?a?iiai? eeneioe o ae?oae oa aio?aeth — o aei?ineeo), eaoa?iio ?
oeiiaaeneio. ?aooa 107 ae?oae ? 114 aei?ineeo (na?aae yeeo 65 ae?oae ?c
na?aaeiueioyaeeei ? 42 – c oyaeeei ia?aa?aii oai?iae, a oaeiae 46 oa 68
aei?ineeo a?aeiiao?aeii) neeaee eiio?ieueio a?oio.

C iaoith aecia/aiiy aeanieo ii?i aeine?aeaeoaaieo iieaciee?a ianoaaeaii
130 aei?ineeo ?aciaeo aeiii??a e?ia? Eoaainueei? iaeanii? noaioe??
ia?aeeaaiiy, a oaeiae 117 caei?iaeo ae?oae a?eii a?ae 1 aei 14 ?ie?a,
ye? i?ioiaeeee icaei?iaeaiiy a i?io?eaeoi??yo i. Eoaainueea ?
?acoeueoaoe oanooaaiiy yeeo neeaee iniiao a?eiaeo ii?i a?io?i?/ieo oa
?ioiieia?/ieo iieaciee?a.

Ee?i?/ia niinoa?aaeaiiy ca noaiii oai?eo aeeth/aei aea/aiiy ?
?a?no?aoe?th neiioii?a oneeaaeiaiue, aiae?c oaeoi??a ?eceeo ?o oi?-

ioaaiiy, aeine?aeaeaiiy iniaeeainoae oneeaaeiaiiai ia?aa?ao,
onoaiiaeaiiy ?aii?o ianiaoeeo?/ieo ee?i?/ieo neiioii?a ?icaeoeo
oneeaaeiaiue. C iaoith ioe?iee cia/aiiy a i?iya? ei?o noaio oai?eo, yeee
ia?aaeoaaa caoai?thaaiith, aaeeeo oaaao i?eae?eyee aiaiianoe/iei aeaiei.

Aeey ae??oaiiy iinoaaeaiiai caaaeaiiy ii?yae c caaaeueiiee?i?/ieie
iaoiaeaie ianoaaeaiiy iaie canoiniaoaaeenue niaoe?aeuei? iaoiaee, ye?
aeicaieeee ioe?ieoe iaoaaie?/i? oa ?ioii? i?ioeane o i?aai?ci? oai?eo.

A?io?i?/ia aeine?aeaeaiiy i?iaiaeeeinue o aeeiai?oe? caoai?thaaiiy: i?e
iaoiaeaeaii? oa ia?aae aeieneith ?c noaoe?iia?o. Aecia/aee ??aaiue IIE
ca eiioeaio?aoe??th eiai iaoaaie?o?a — iaeiiiaiai ae?aeueaeaa?aeo
(IAeA) ? ae??iiaeo eii’thaao?a (AeE) niaeo?ioioiiao?e/ii (A.A.Aaa?eeia,
?.?. I?oei?oaeia,1983), aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie —
eaoaeace oioieaei??iao?e/iei iaoiaeii (I.A.Ei?iethe ? ni?aaao.,1988) ?
noia?ieneaeaeeniooace (NIAe) (I.I.Iaea?aae/, I.I.Aie?eia, 1983 a
iiaeeo?eaoe?? ?.?.Aeoa?i?ii? o ni?aaao.,1984). Ioe?ieo nooiaith
?ioieneeaoe?? i?iaiaeeee ii eiioeaio?aoe?? “NI” (A.A.I?eieae/ee ?
ni?aaao., 1991) Aeey oa?aeoa?enoeee nenoaie aeeicaii?ae?a aecia/aee o
ieaci? e?ia? ??aaiue o?iiaienaio OoA2 (ca noaa?eueiei iaoaaie?oii
OoA2), eiioeaio?aoe?th i?inoaaeaiaeei?a (IA) I2 (ca noaa?eueiei
iaoaaie?oii 6-eaoi-IAF1a), F2a ? A2 ?aae?i?ioiiei iaoiaeii ?c
aeei?enoaiiyi noaiaea?oieo eiia?oe?eieo iaai??a ae?iaieoeoaa ?inoeoooo
?cioii?a Oai?nueei? Aeaaeai?? Iaoe; aeine?aeaeoaaeanue eiioeaio?aoe?y
ii?i?aeieo iaioeae?a: b-aiaei?oeia, iao-aie?oae?ia oa eae-aie?oae?ia a
e?ia? ?aae?i?ioiiei iaoiaeii c aeei?enoaiiyi eiia?oe?eieo oano-iaai??a
o??ie DRG ae?iaieoeoaa NOA. Ai?no a1-oeiiceio a e?ia? aecia/aany
?aae?i?ioiiei iaoiaeii o eaai?aoi??? ?ioiia?ioaoiieia?? (caa.eaai?aoi???
i?io. A.I.Oeya?/) Iineianueeiai IAe? e?iaicai?iiee?a ? ai?iiiaeueieo
i?aia?ao?a.

?ioiiaaiaoe/i? oanoe aeeth/aee oeioaaiiy aioeaai?a nenoaie HLA eieon?a
A, A, N ? DR noaiaea?oiei aeaii?enooi/aoei i?e?ie?ioioeeoioiene/iei
iaoiaeii (?.Oerasaki et al., 1978 a iiaeeo?eaoe??
TH.I.Ca?aoeueei?,1983).

Aeey oa?aeoa?enoeee ?ioiieia?/iiai aiiainoaco aea/aee iieacieee
ee?oeiii? oa aoii?aeueii? eaiee ?ioi?oaoo ?c aecia/aiiyi e?eueeino? O-,
A-e?ioioeeo?a, O-oaeia??a/?iaeoeoi??a, O-noi?ani??a/oeeoioienee?a,
IE-ee?oei oeeoioiene/iei iaoiaeii c eiia?oe?eieie iiiieeiiaeueieie
aioeo?eaie eean?a CD3, CD4, CD8, CD22, CD16 o??ie «Ortho Diagnostic
Systems Inc» (USA) a?aeiia?aeii c iaoiaee/ieie ?aeiiaiaeaoe?yie
“Oeeoioiene/aneee iaoiae aeey ii?aaeaeaiey noa-

iiioeyoeee O- eeaoie iiiieeiiaeueiuie aioeoaeaie” i?ae ?aae.
O.I.Aaenea?a (?eaa, 1987); ooieoe?iiaeueii? aeoeaiino? NE-ee?oei
(TH.?.C?i?i ? ni?aaao., 1984); ??aiy Oe?E o ne?iaaooe? e?ia? iaoiaeii
i?aoeei?oaoe?? a 2%, 3,5%, ? 6% ?ic/eiao iie?ao?eaiae?eieth c
iieaeoey?iith ianith 6000 aeaeueoii ii Digeon et al. (1977) a
iiaeeo?eaoe?? A.I.O?ieiaa oa ni?aaao.(1986); eiioeaio?aoe??
?ioiiaeiaoe?i?a ne?iaaoee e?ia? eean?a A, I, G iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? a aae? (Mancini et al., 1965). Nainea?e?caoe?y ?ioiioeeo?a
ia?eoa?e/ii? e?ia? aei aooiaioeaai?a aea/aeanue a ?aaeoe?? ?AIE
eai?ey?iei iaoiaeii c eiiieaeniei aioeaaiii oeiono (OA), eaaai?a (EA),
e?iii?ioa?aeii ia/?iee ethaeeie (EIE) (Rosenberg and David, 1979);
oaaioeeoa?ia aeoeai?noue iiiioeeo?a (OAI) ia?eoa?e/ii? e?ia? –
/aoa/eiaei iaoiaeii (A.I.O?ieia oa ni?aaao., 1989).

*ooeea?noue A-ee?oei aei e?ea?nueeeo i?aia?ao?a ioe?ithaaeanue ca ?o
caeaoi?noth i?eeeiaoe aei neea (LAI-oano). Aeey ioe?iee noaio nenoaie
aaiinoaco aecia/aee aa?aaaoe?th, aaeaaceaio aeoeai?noue o?iiaioeeo?a o
e?ia? (A.ss. Niieyieoeueeee ? ni?aaao., 1985), cn?aeaiiy aaiicii? e?ia?
oi?o?oe??iaaiei i?e?iiaoiaeii, /an ?aeaeueoeeo?eaoe?? ieacie,
i?io?iiaeiiaee ?iaeaen ? e?euee?noue o?a??iiaaio (A.I.Aaeoaea ?
ni?aaao., 1980).

Aea/aiiy i?e?ioee?eoeyoe?? i?iaiaeeee iaoiaeii a?ii?e?ineii??
aoeueaa?ii? eii’thieoeae (AAE), yea aeiiiaithaaee ii?oiiao???th
eai?ey??a i?aoueiaiai eiaea. E?euee?nio ioe?ieo ii?ooaiue
i?e?ioee?eoeyoe?? i?iaiaeeee oeyoii a?aooaaiiy eii’thieoeaaeueieo
?iaeaen?a: noaeeiiiai — E?1, aioo??oiueinoaeeiiiai — E?2, iicanoaeeiiiai
— E?3, caaaeueiiai eii’thieoeaaeueiiai ?iaeaeno — E?0 = E?1 + E?2 + E?3
(N.A.Naeaciueia oa ni?aaao., 1995).

Iaoaiaoe/ia ia?iaea io?eiaieo aeaieo cae?enithaaeanue ia AII IBM
Pentium 200 Pci Super VGA, c aeei?enoaiiyi i?ia?aie “I?iaiic-4”,
ni?yiiaaii? ia ia?iaeo ee?i?/ii? oa eaai?aoi?ii? ?ioi?iaoe??.

Ee?i?/ia oa?aeoa?enoeea ? e?eoa??? i?iaiicoaaiiy oneeaaeiaieo oi?i ei?o.
Aeey oa?aeoa?enoeee ii??aithaaeenue ee?i?/i? iieacieee o aeaio a?oiao
oai?eo ia e?? — c iayai?noth (306 in?a) ? a?aenooi?noth (311 in?a)
oneeaaeiaiue. Oea aeicaieeei i?iaiae?coaaoe a?eia?, aiaiianoe/i?,
ia’?eoeai? oaeoi?e o oai?eo iaio a?oi, aeaye? c yeeo, ca aeaieie
e?oa?aoo?e iiaeooue aieeiooe ia ?icaeoie oa iiaeaeueoee ia?aa?a o ieo
ei?o. Aeyaeeinue, ui ieoiia aaaa oneeaaeiaiue na?aae ae?oae
aecia/a?oueny a?eii. Oae, o ae?oae ia?oiai ?ieo aeeooy /anoioa
oneeaaeiaiiai ia?aa?ao neeaea 84,8%, a oie /an ye o a?oi? oai?eo a?ae 1
aei 3 ?ie?a — 69,4%, a o ae?oae c 3 aei 6 ?ie?a ? a?ae 6 aei 14 ?ie?a —
50% ? 41,6% a?aeiia?aeii. Oaeei

/eiii, o a?oe? aei 1 ?ieo oneeaaeiaiiy cono??/aeenue a 1,2 — 2,0 ?ace
/ano?oa ii??aiyii c ae?oueie ?ioeo a?eiaeo a?oi (ia?aaaaeii iiaaiii?y,
ea?eiaio?aoa?o, aioa?eo). O ae?oae c 3 aei 6 ?ie?a iae/ano?oa
cono??/aany a?iio?o (16,2%), c 6 aei 14 – aia?ia (12,7%). O aei?ineeo
i?ney oneeaaeiaiue aeeoaeueii? nenoaie ia?aaaaeii aeieeaa noiiaoeo
(10,7%). Niieo/aiiy 2-o ? a?eueo oneeaaeiaiue o ae?oae aoei a??ia?aeii
/ano?oa, i?ae o aei?ineeo (47,6% ? 27,2% a?aeiia?aeii).

E?euee?noue oneeaaeiaieo oi?i ca?eueooaaeanue a?aeiia?aeii aei oyaeeino?
iaoieia?/iiai i?ioeano. Oae, na?aae ae?oae c oyaeeei ia?aa?aii oai?iae
oneeaaeiaiiy ?a?no?oaaeenue a 1,5 ?ace, a o aei?ineeo a 1,4 ?ace /ano?oa
i?ae c na?aaei? oyaeeei.

Iieaciai, ui /anoioa oneeaaeiaiiai ia?aa?ao ei?o aoea nooo?ai ieae/a o
ae?oae, ye? aoee ?ai?oa uaieai?. Oae oneeaaeiaiiy a a?oi? iai?euaieaieo
ae?oae, a a?oe? a?ae 1 aei 3 ?ie?a, cono??/aeenue ia 19,1% /ano?oa i?ae,
o i?euaieaieo o??? ae a?eiai? a?oie. Aiaeia?/ia ia?aaaaeaiiy
oneeaaeiaiiai ia?aa?ao ei?o (ia 23%) o iai?euaieaieo iaei i?noea ? a
a?oi? oai?eo a?eii 4 — 6 ?ie?a. Oaeei /eiii, iayai?noue a aiaiiac?
aaeoeeiii?io?eaeo?ee i?ioe ei?o ? ni?eyoeeaith i?iaiinoe/iith iciaeith a
ieai? aeaaeeiai ia?aa?ao oai?iae.

Onoaiiaeaii, ui ia ia?aa?a ei?o cia/iee aieea ia? noai, ia?aaeoth/ee
caoai?thaaiith. A a?oi? ae?oae 1-ai ?ieo aeeooy, ye? iathoue
oneeaaeiaiiy, 88,9% ciaoiaeeeinue ia ooo/iiio oa ?aiiueiio ci?oaiiio
aiaeoaaii?; a aiaiiac? iaoa??a a?eueo i?ae iieiaeie c ieo iaee i?noea
iaoieia?/iee ia?aa?a aaa?oiino? oa iieia?a (aanoic ia?oi? aai ae?oai?
iieiaeie, aiai?y, o?ii?/ia aioo??oiueioo?iaia a?iien?y, ia?aae/ani?
iieiae). Oneeaaeiaiiy ei?o a 8 ?ac?a /ano?oa cono??/aeenue o
a?iio?io?e?a, ye? no?aaeaeaee a?iiaa?oai?iicii, a?eueo i?ae a 2 ?ace o
ae?oae c aenoaeaoeaiei ae?aoacii, a 5 ?ac?a – c ?ao?oii, a 2,5 ?ace – c
aiai??th. 68,9% ae?oae c oneeaaeiaiiyie ia iiiaio caoai?thaaiiy ei?ii
aoee a ia??iae? ?aeiiaaeanoeaioe?? ?ioeie ?ioaeoe?eieie caoai?thaaiiyie
(A?A?, aia?ie, aino?? eeoeia? caoai?thaaiiy). ?icaeoeo oneeaaeiaiue
ni?eyee oaeiae noiooi? o?ii?/i? caoai?thaaiiy i?aai?a aeeoaiiy, o?ii?/ia
iaoieia?y iiniaeioee, oeoieiai-eeoeiaiai o?aeoo.

Oneeaaeiaiee ia?aa?a ei?o o aei?ineeo /ano?oa ?icaeaaany o in?a, ye?
iaee eiioaeo c i?ioan?eieie oe?aeeeainoyie (oiene/i? iiethoaioe,
caaaciaai?noue, eiio?anoi? ci?ie oaiia?aoo? oa ?i.), a oaeiae
no?aaeaeaee i?eioeiiaith e aeeiaieueiith caeaaei?noth.

Iaie aoea ?ic?iaeai? e cai?iiiiiaai? i?iaiinoe/i? oaaeeoe? iiaeeeaino?
?icaeoeo oneeaaeiaiue ei?o (oaae.1 oa 2).

?iaioa c oaaeeoeyie iieyaaea a ianooiiiio: ciaoiaeyoue

a?aeiia?aeiee ae?aaiinoe/iee eiao?oe??io aeey eiaeii? iciaee, i?ney /iai
an? eiao?oe??ioe i?aenoiiaothoue. sseui noia ia?aaeuo? /eneiaee ii??a
+17 aeey ae?oae, +25 aeey aei?ineeo ? a?eueoa, oi ?iaeoueny aeniiaie, ui
e?? i?eeia oneeaaeiaiee oa?aeoa?.

Oaaeeoey 1

Oaeoi?e, ui ni?eythoue ?icaeoeo oneeaaeiaiue o ae?oae oai?eo ia e??

Ae?oe (n=394)

Oaeoi?e ?eceeo

E?euee?noue aae?a

Iayai?noue

oaeoi?a

A?aenooi?noue

oaeoi?a

O?ii?/i? ?iceaaee oa?/oaaiiy

+8,0

-1,0

?ao?o ??-??? nooiaith

+6,0

-0,5

Aiai?y ??-??? nooiaith

+3,5

-0,5

Aea?a?/i? caoai?thaaiiy

+3,0

-0,5

Aioa?ia?ic

+2,5

-0,5

Ia??iae ?aeiiaaeanoeaioe?? ?ioaeoe?eieie oai?iaaie

+5,0

-1,0

O?ii?/ia iaoieia?y iiniaeioee

+4,0

-0,5

Iiaoi?i? ?ani??aoi?i? caoai?thaaiiy

+6,0

-1,0

Iani?eyoeea? iaoa??aeueii-iiaooia? oiiae

+3,5

-0,5

Caoai?thaaiiy aeeoaeueii? nenoaie

+6,0

-0,5

A?aenooi?noue aaeoeeiaoe??

+5,0

-5,0

Oyaeeee ia?aa?a oai?iae

+3,0

-2,0

A?e aei 3-o ?ie?a

+4,5

-1,5

Iaeneiaeueia noia aae?a

+60,0

-15,0

Oaaeeoey2

Oaeoi?e, ui ni?eythoue ?icaeoeo oneeaaeiaiue o aei?ineeo oai?eo ia e??

Aei?ine? (n=223)

Oaeoi?e ?eceeo

E?euee?noue aae?a

Iayai?noue oaeoi?a

A?aenooi?noue oaeoi?a

O?ii?/i? ?iceaaee o?aaiaaiai o?aeoo

+4,5

-0,5

Aiai?y ??-??? nooiaith

+3,5

-1,0

Aea?a?/i? caoai?thaaiiy

+2,5

-0,5

Iani?eyoeea? iaoa??aeueii-iiaooia? oiiae

+5,0

-1,0

O?ii?/ia iaoieia?y iiniaeioee

+9,0

-1,5

Iiaoi?i? ?ani??aoi?i? caoai?thaaiiy

+7,0

-1,0

Ia??iae ?aeiiaaeanoeaioe?? ?ioaeoe?eieie oai?iaaie

+9,5

-2,5

Ceiaaeeaaiiy aeeiaieai

+7,5

-0,5

Othothiiaa caeaaei?noue

+8,0

-3,0

I?ioan?ei? oe?aeeeaino?

+8,5

-0,5

Caoai?thaaiiy aeeoaeueii? nenoaie

+8,5

-0,5

Oyaeeee ia?aa?a oai?iae

+0,5

-1,0

Iaeneiaeueia noia aae?a

+74,0

-13,5

?ioii? oa ?ioiiaaiaoe/i? iieacieee o oai?eo c ??ciei ia?aa?aii ei?o .

A aino?iio ia??iae? ei?o caaaeueia ni?yiiaai?noue ci?i iieaciee?a
?ioi?oaoo oa?aeoa?ecoaaeanue i?eai?/aiiyi O-ee?oeiii? eaiee, ui
i?iyaeyeinue cieaeaiiyi e?eueeino?, ye caaaeueii? e?eueeino? ND3, oae ?
noaiiioeyoe?? ND4-e?ioioeeo?a (oaae.3). A?aeiinia ia?aaaaeaiiy
O-noi?ani??a/oeeoinoaoee?a i?eaiaeeei aei cieaeaiiy ?ioii?aaoeyoi?iiai
?iaeaeno ND4/ND8 ? noi?iaiaeaeoaaeiny iiaeeaeaiiyi aeai?an?? O-nenoaie.

Oaaeeoey 3a

Iieacieee ?ioi?oaoo o oai?eo na?aaeiueioyaeeith oi?iith ei?o

Iieacieee

A?e ianoaaeaieo (?iee)

1-3

3,1 — 6

6,1 – 14

aei?ine?

Ia?aa?a oai?iae

iaoneeaaeiaiee

oneeaaeiaiee

iaoneeaaeiaiee

oneeaaeiaiee

iaoneeaaeiaiee

oneeaaeiaiee

iaoneeaaeiaiee

oneeaaeiaiee

Na?aaeiueioyaeea oi?ia (M±m)

CD3,*109/e

CD4,*109/e

CD8,*109/e

CD4/ CD8

CD22,*109/e

CD16,*109/e

?Oe IE, %

Oe?E a/e

Aaeee., a/e

Na?aae., a/e

Ae??ai., a/e

?AIE c OA

O?

O*

2,2±0,1

1,2±0,04

0,97±0,04

1,23±0,07

0,83±0,025

0,2±0,01

20,5±1,4

2,41±0.25

0,95±0,01

0,9±0,4

0,54±0,4

0,89±0,05

19,3±1,7

2,1±0,2

(n=22)

1,7±0,08***

0,8±0,03***

0,86±0,035*

0,94±0,06***

0,77±0,01*

0,17±0,01*

15,7±1,2**

3,22±0.3*

1,0±0,02*

1,36±0,8*

0,86±0,5*

0,77±0,03*

14,6±1,4*

1,6±0,12*

(n=29)

2,0±0,1

1,0±0,04

0,92±0,04

1,1±0,05

0,58±0,03

0,26±0,012

22,4±1,4

3,2±0.15

1,2±0,07

1,2±0,06

0,8±0,04

0,85±0,03

17,3±1,6

1,9±0,12

(n=53)

1,7±0,08**

0,79±0,03***

0,83±0,03*

0,96±0,04

0,46±0,023***

0,22±0,011**

17,5±0,9**

3,7±0,19*

1,0±0,05*

1,7±0,09***

1,0±0,05**

0,76±0,03*

12,0±1,2**

1,4±0,1***

(n=50)

1,5±0,08

0,78±0,04

0,6±0,05

1,3±0,06

0,4±0,02

0,28±0,01

35,4±1,8

3,9±0,15

1,36±0,04

1,5±0,08

1,04±0,05

0,76±0,02

19,4±1,0

2,6±0,15

(n=84)

1,3±0,06*

0,58±0.03***

0,6±0.033

0,98±0.04***

0,34±0,017*

0,24±0,009**

26,7±1,3***

4,5±0,2**

1,25±0,03*

1,92±0,1***

1,33±0,07***

0,7±0,02*

15,0±0,8***

2,0±0,1***

(n=54)

1,2±0,1

0,63±0,04

0,45±0,02

1,4±0,1

0,34±0,017

0,29±0,009

32,5±2,0

3,6±0,12

1,26±0,06

1,4±0,07

0,94±0,05

0,82±0,035

19,4±1,0

2,1±0,1

(n=53)

0,9±0,06**

0,44±0,02***

0,4±0,01*

1,1±0,05**

0,21±0,013***

0,25±0,09***

23,0±1,4***

4,2±0,2**

1,05±0,06**

2,0±0,1***

1,15±0,053**

0,73±0,03*

14,1±0,71***

1,6±0,09***

(n=53)

I?ei?oee p – a??ia?aei?noue iii?ae iieacieeaie: * — p < 0,05; ** - p < 0,01; *** - p < 0,001. ? ?ic?aoiaaii iii?ae oneeaaeiaiei ? iaoneeaaeiaiei ia?aa?aii. A?e 3,1; 6,1 icia/a? iaeio aeiao i?ney iiaieo ?ie?a. Oaaeeoey 3a Iieacieee ?ioi?oaoo o oai?eo oyaeeith oi?iith ei?o Iieacieee A?e ianoaaeaieo (?iee) 1-3 3,1 - 6 6,1 – 14 aei?ine? Ia?aa?a oai?iae iaoneeaaeiaiee oneeaaeiaiee iaoneeaaeiaiee oneeaaeiaiee iaoneeaaeiaiee oneeaaeiaiee iaoneeaaeiaiee oneeaaeiaiee Oyaeea oi?ia (M±m) CD3*109/e CD4*109/e CD8*109/e CD4/ CD8 CD22,*109/e CD16,*109/e ?Oe IE, % Oe?E a/e Aaeee., a/e Na?aae., a/e Ae??ai., a/e ?AIE c OA O? O* 1,4±0,07 0,69±0,03 0,82±0,02 0,85±0,05 0,55±0,02 0,16±0,01 11,4±0,8 3,95±0,1 1,06±0,02 1,81±0,2 1,08±0,36 0,64±0,02 12,5±1,1 1,6±0,1 (n=15) 1,2±0,06* 0,37±0,02*** 0,75±0,015* 0,5±0,03*** 0,43±0,02*** 0,12±0,01** 7,1±0,5*** 4,67±0,3* 1,12±0,02* 2,28±0,2* 1,32±0,42* 0,53±0,02*** 9,7±0,8* 1,2±0,08** (n=61) 1,5±0,07 0,7±0,03 0,8±0,04 0,87±0,05 0,42±0,021 0,2±0,01 12,6±0,6 4,1±0.17 0,9±0,05 2,0±0,1 1,2±0,06 0,7±0,036 11,4±0,9 1,2±0,09 (n=14) 1,1±0,06*** 0,37±0,02*** 0,7±0,03* 0,53±0,03*** 0,34±0,015** 0,15±0,008*** 9,4±0,47*** 4,6±0,2* 0,75±0,04** 2,3±0,1* 1,45±0,07** 0,54±0,025*** 8,2±0,4*** 0,8±0,035*** (n=80) 1,2±0,06 0,52±0,02 0,58±0,03 0,9±0,03 0,3±0,013 0,22±0,007 20,0±1,0 4,7±0,16 1,2±0,03 2,1±0,1 1,4±0,07 0,6±0,016 13,2±0,7 1,9±0,1 (n=31) 0,8±0,04*** 0,27±0.01*** 0,48±0.023* 0,56±0.04*** 0,2±0,01*** 0,17±0,04*** 11,3±0,6*** 5,2±0,2* 1,1±0,03** 2,4±0,1* 1,7±0,09** 0,55±0,02* 8,6±0,4*** 1,2±0,07*** (n=28) 0,9±0,05 0,37±0,03 0,4±0,02 0,94±0,06 0,28±0,012 0,23±0,004 19,3±0,9 4,3±0,2 0,83±0,025 2,15±0,1 1,32±0,07 0,66±0,03 11,5±0,6 1,2±0,07 (n=73) 0,6±0,03*** 0,21±0,015** 0,35±0,015* 0,6±0,04*** 0,24±0,01** 019±0,03*** 13,4±0,7*** 5,1±0,26** 0,7±0,02** 2,8±0,14*** 1,6±0,08** 0,55±0,03** 9,7±0,45** 1,0±0,06* (n=60) I?ei?oee p – a??ia?aei?noue iii?ae iieacieeaie: * - p < 0,05; ** - p < 0,01; *** - p < 0,001. ? ?ic?aoiaaii iii?ae oneeaaeiaiei ? iaoneeaaeiaiei ia?aa?aii. A?e 3,1; 6,1 icia/a? iaeio aeiao i?ney iiaieo ?ie?a. I?e oyaeeiio oa oneeaaeiaiiio ia?aa?ao ei?o niinoa??aaeinue ciaioaiiy e?eueeino? iaoo?aeueieo e?ea??a (NE-ee?oei), i?eai?/aiiy ?o ooieoe?iiaeueii? aeoeaiino?, oiae? ye i?e na?aaeiueioyaeeiio ia?aa?ao oai?iae ca?eueoaiiy e?eueeino? NE-ee?oei ia oe? aeao?oeeoo ?o ooieoe?? aaaaeaee eiiiainaoi?iei. E?? noi?iaiaeaeoaaany i?aeneeaiiyi aooi?ioiieo ?aaeoe?e, ui aeieoiaiooaaeinue ciaioaiiyi i?a?aoe?eiiai ?iaeaeno ?AIE c OA. Oea na?ae/eoue i?i iaaaeaeaaoi?noue ?ioiii? a?aeiia?ae? i?e oneeaaeiai?e oi?i? ei?o. Aeen?ioiiaeiaoe?iai?y, yea iaea i?noea o a?eueoino? ianoaaeaieo ia e??, i?aeneethaaeanue a?aeiia?aeii c?inoaiith oyaeeino? iaoieia?/iiai i?ioeano, ? aoea iaeneiaeueiith o in?a c oneeaaeiaiei ia?aa?aii oai?iae. O a?oi? oai?eo c oneeaaeiaiiyie a?aei?/aeinue nooo?aa c?inoaiiy ai?noo iaea?eueo iaoiaaiieo na?aaeiuei- oa ae??aiiiieaeoey?ieo ?ioiieo eiiieaen?a. Aeyaeaii aca?iica’ycie i?ae eiioeaio?aoe??th a e?ia? Oe?E oa e?euee?noth O-ee?oei (r= - 0,697), a oaeiae ai?noii na?aaeiueiiieaeoey?ieo ?ioiieo eiiieaen?a ? cia/aiiyi ?ioii?aaoeyoi?iiai ?iaeaeno CD4/CD8 (r= - 0,735). Onoaiiaeaii, ui iacaeaaeii a?ae a?eo oa noao? oai?eo ia e??, a?aeiia?aeii aei oyaeeino? oai?iae, a oaeiae i?e iayaiino? oneeaaeiaiue a?aei?/a?oueny ca?eueoaiiy /anoioe oaiioei?a ILA-A2, A7, A13, Aw35, DR2 ? cieaeaiiy /anoioe HLA-A1, A11 ? A8, ui iiaea aooe e?eoa??yie aeey i?iaiico oneeaaeiaiiai oa oyaeeiai ia?aa?ao oai?iae (oaae.4). Oaaeeoey4 *anoioa aeyaeaiiy aioeaai?a nenoaie HLA o oai?eo ia e?? caeaaeii a?ae ia?aa?ao oai?iae Aioeaaie HLA Caei?ia? Oai?? ia e?? Ia?aa?a ei?o Iaoneeaaeiaiee Oneeaaeiaiee M±m (%) A1 32,5 40,1 26,1 A2 42,7 32,7 53,7 A11 11,1 21,1 10,1 A7 31,3 22,0 50,8 A8 21,7 34,9 13,2 A13 17,4 19,8 31,4 Aw35 13,0 8,6 23,9 DR2 35,9 27,6 49,1 Cieaeaiiy ?iaeaeno oeeoioiene/iino? NE, oaaioeeoa?iiai ?iaeaeno niinoa??aaeinue a?eueo i?ae a 1,5 ?ace o iin??a niaoeeo?/iino? HLA-Bw35, ui na?ae/eoue i?i iaaaoeai? ci?ie a nenoai? NE-ee?oei ? oaaioeeoico i?e iayaiino? aeaeeth HLA-Bw35. Iayai?noue o oaiioei? oai?eo ia e?? ia?ea?a HLA-B8 niieo/aeanue c a?eueo aenieei ??aiai CD22 - ? CD4 -e?ioioeeo?a, ? a?eueo iecueeei - CD8-ee?oei, i?ae o HLA-B8-iaaaoeaieo oai?eo. O ca’yceo c oeei, o iin??a aeaiiai aioeaaio eiao?oe??io CD4/CD8 aoa o 2,9 ?ace aeua ii??aiyii c eiai a?aenooi?noth. I?enooi?noue aeaeeth HLA-B8 o oai?eo ia e?? ni?aiaaeaea c a?eueo aenieeie oeo?aie i?ioeei?iaeo aioeo?e a ?AAA. I?ioeeaaei? ci?ie iieaciee?a ?ioi?oaoo aeyaeyeenue i?e iayaiino? aioeaai?a HLA-A7, HLA–A13 ? HLA-DR2. Iin?enoai oeeo aioeaai?a noi?iaiaeaeoaaeinue cia/ii cieaeaieie iieacieeaie O-oaeia??a, eiao?oe??ioo CD4/CD8 ? oeo?o i?ioeei?iaeo aioeo?e. Oaeei /eiii, aioeaaie HLA-Bw35, HLA-A7, HLA-B8 HLA-A13 ? HLA-DR2 ? iaeieie c oaeoi??a ?icaeoeo oiai aai ?ioiai ia?aa?ao ei?o ye ?acoeueoao cia/ieo ci?i ?ioiieo iieaciee?a. Noai iaoaaie?/ieo i?ioean?a o oai?eo ia ??ci? oi?ie ei?o Onoaiiaeaii, ui a aino?iio ia??iae? ei?o a?aeaoaa?oueny aeoeaaoe?y i?ioean?a IIE, nooi?iue ae?aco yeeo caeaaeeoue a?ae a?eo oai?eo ? aecia/a?oueny nooiaiai oyaeeino? oai?iae oa iayai?noth oneeaaeiaiue. I?e ?icaeoeo oyaeeeo oa oneeaaeiaieo oi?i ei?o eiioeaio?aoe?y AeE ? IAeA aoee iaeneiaeuei?, ui noi?iaiaeaeoaaeinue ?icaeoeii neiae?iio “iaoaaie?/ii? ?ioieneeaoe??”. I?e oeueiio iieaciee eiioeaio?aoe?? “NI” o oai?eo ia e?? neeaa 3,14±0,07 a/e (i?e ii?i? 0,54±0,02 a/e; P<0,001), Iaaooue, cia/ia ?ioaineo?eaoe?y IIE ni?ey? oi?ioaaiith iaea?eueoeo ?ioiieo cnoa?a, ui aeieoiaioo?oueny iayai?noth i?yieo ? cai?ioieo ei?aeyoeaieo ca’yce?a i?ae ??aiai iaoaaie?o?a ia?ieneaeaoe?? e?i?ae?a oa ieceith aeayeeo ?ioiieia?/ieo iieaciee?a o aeaieo oai?eo. Cie?aia, cai?ioiy caeaaei?noue iaea i?noea i?ae ai?noii AeE ? eiao?oe??ioii ?ioii?aaoeyoe?? CD4/CD8, eiioeaio?aoe??th IAeA ? e?euee?noth O-e?ioioeeo?a, ai?noii AeE ? /eneii O-oaeia??a. I?yiee ei?aeyoeaiee ca’ycie anoaiiaeaii i?ae ??aiai AeE ? eiioeaio?aoe??th Oe?E. A aino?iio ia??iae? ei?o a?aei?/aeanue aeoeaaoe?y ia?aooai?aiiy a?ao?aeiiiai? eeneioe, ui i?iyaeyeinue o a??ia?aeiiio ca?eueoaii? o e?ia? eiioeaio?aoe?? ?? iaoaaie?o?a: i?inoaoeeee?io, o?iiaienaio, IAA2, IAF2a, eaeeio???i?a. I?eaa?oaei oaaao c?inoaiiy ai?noo i?inoaii?ae?a c aa?aaaoe?eieie, aacieiino?eeoi?ieie ? ?ioiinoi?aneaieie aeanoeainoyie iacaeaaeii a?ae a?eo oai?eo oa aoei iaeneiaeueiei i?e iayaiino? oneeaaeiaieo oi?i ei?o (iiaaiii??, iai?iaiaioeaoae?oe) (?en.2). Ii aeaiei ei?aeyoe?eiiai aiae?co IAA2 aieeaathoue ia ?ioiio nenoaio, i?eai?/oth/e ooieoe?iiaeueio aeoeai?noue iaoo?aeueieo e?ea??a (r=-0,691). Aea/aiiy ai?noo ii?i?aeieo iaioeae?a aeyaeei ??ciini?yiiaaiee oa?aeoa? ?o ci?i. Oae, i?e iaaeoiaeaeaii? aei noaoe?iia?o eiioeaio?aoe?y b-aiaei?o?io aoea cieaeaiith a on?o ianoaaeaieo oai?eo. Aea i?e oyaee?e oi?i? c oneeaaeiaiiyie ??aaiue iaoaaie?oo aoa ia 20-30%% ieae/a /ei o oai?eo c aeaaeeei ia?aa?aii. Iiaoi?i? aeine?aeaeaiiy ia ae?oaiio oeaei? oai?iae aeicaieeee a?aei?oeoe c?inoaiiy eiai ai?noo a a?oiao oai?eo ?c ni?eyoeeaei ia?aa?aii ei?o. I?e ?icaeoeo oneeaaeiaiue ??aaiue b-aiaei?o?io cieaeoaaany aeae?. O ae?oae aei 3-o ?ie?a a?aeaoaaeinue i?ia?aneaia eiai cieaeaiiy o 3-4 ?ace iacaeaaeii a?ae iayaiino? oneeaaeiaiue. ?en.2 Ci?ie iniiaieo iaoaaie?o?a o oai?eo c oneeaaeiaiei oa iaoneeaaeiaiei ia?aa?aii ei?o. Ia o?aoueiio oeaei? a?aei?/aeinue i?aeaeuaiiy ai?noo b-aiaei?o?io a on?o a?oiao, aea iiaiiai a?aeiiaethaaiiy ia aoei. Ai?no iao-aieaoae?io cieaeoaaany a on?o ianoaaeaieo ? aeinyaaa iaeiaioeo iieaciee?a o ae?oae ?aiiueiai a?eo c oneeaaeiaiei ia?aa?aii ei?o (159387,7na/ie). A i?ioeeaaeiiio ci?ithaaany ai?no eae-aieaoae?io. Ca?eueoaiiy eiai eiioeaio?aoe?? a?aei?/aeinue i?e c?inoaii? oyaeeino? ia?aa?ao oai?iae ? caeaaeaei a?ae oneeaaeiaiue. Anoaiiaeaii iiceoeaiee ei?aeyoeaiee aca?iica’ycie i?ae ai?noii b-aiaei?o?io ? eiao?oe??ioii CD4/CD8 (r=+0,714), a oaeiae i?ae caaaeueiith e?euee?noth O-e?ioioeeo?a (r=+0,638). O an?o ianoaaeaieo c oneeaaeiaieie oi?iaie ei?o niinoa??aaeinue cieaeaiiy ai?noo a1-oeiiceio (ai?iiio aeei/eiai? caeice) a 1,5 -1,8 ?ac?a. I?e oeueiio a aeiaaeeao oneeaaeiaiiai ia?aa?ao ei?o ai?no ai?iiio aoa a??ia?aeii ieae/a aiaeia?/iiai o oai?eo c iaoneeaaeiaiei ia?aa?aii. Oae, o ae?oae aei 6 ?ie?a, ui ia?aiinyoue e?? na?aaeiuei? oyaeeino?, ai?no a1-oeiiceio i?e iayaiino? oneeaaeiaiue aoa o 1,5 ?ace ieae/a, i?ae i?e aeaaeeiio ia?aa?ao oai?iae; o ae?oae 6,1-14 ?ie?a oa o aei?ineeo a?aeiia?aeii a 1,5 ? a 1,8 ?ace. Iiae?aia oaiaeaioe?y a?aei?/aeany e i?e oyaeeiio ia?aa?ao ei?o, c o??th eeoa ??cieoeath, ui nooi?iue cieaeaiiy a1-oeiiceio aoea a?eueo ae?aaeaiith, a ii??aiyii? c? na?aaei?oyaeeei ia?aa?aii ei?o (oaae.5). Oaaeeoey 5 Ai?no a1-oeiiceio o ae?oae oai?eo ia e?? A?oie ianoaaeaieo A?e ianoaaeaieo (?iee) 1-3 3,1 - 6 6,1 – 14 Ia?aa?a oai?iae iaoneeaaeiaiee oneeaaeiaiee iaoneeaaeiaiee oneeaaeiaiee iaoneeaaeiaiee oneeaaeiaiee Ai?no a1-oeiiceio (ia/ie) M±m E?? ? 2,8±0,2 3,3±0,18 n=22 1,9±0,12** 2,5±0,15** n=29 2,0±0,15 2,7±0,2 n=31 1,3±0,1** 1,8±0,15** n=21 1,4±0,12 1,9±0,11 n=34 0,8±0,07** 1,5±0,1* n=30 ?? 2,3±0,15 2,9±0,21 n=5 1,2±0,09* 2,1±0,12** n=51 1,5±0,1 2,3±0,12 n=9 0,8±0,04** 1,5±0,1** n=19 0,9±0,06 1,6±0,1 n=31 0,5±0,03** 1,1±0,07** n=28 Caei?ia? ae?oe 4,3±0,18 n=32 3,2±0,15 n=36 2,3±0,1 n=30 I?ei?oee. Oi?ie oai?iae: ? – na?aaeiueioyaeea; ?? – oyaeea. A /enaeueieeo - aino?ee ia??iae oai?iae; a ciaiaiieeo - ?aeiiaaeanoeaioe?y; p – a??ia?aei?noue i?ae iieacieeaie: * - p < 0,01; ** - p < 0,001. ? ?ic?aoiaaii iii?ae oneeaaeiaiei oa iaoneeaaeiaiei ia?aa?aii oai?iae. Aeyaeaiee iaaiee ca’ycie i?ae ia?aa?aii ei?o ? oa?aeoa?ii oneeaaeiaiue a?ae ai?noo a1-oeiiceio: i?e a?eueo iecueeeo eiai iieacieeao /ano?oa niinoa??aaeeny a?iioiiano?oeoeai? oneeaaeiaiiy (r=- 0,35), noiiaoeoe (r=- 0,27), ae?a?ay (r=- 0,29), noeeuei?noue aei oa?/iai? aea?a?? (r=- 0,32). I?e ?icaeoeo noaiicoth/iai noaiicoth/iai ea?eiaio?aoa?oo ai?no a1-oeiiceio aoa a 1,4 ?ace iaioei, i?ae i?e ea?eiaio?aoa?o?, yeee ia?aa?aaa aac noaiico.O oai?eo ia e?? c oaeeie oneeaaeiaiiyie ye aioeaoae?o ? iai?ia?o aoei a?eueo o?eaaea cieaeaiiy aa?iiio. Na?aae ianoaaeaieo a?eiaeo a?oi iae/ooeea?oeie aei cieaeaiiy a1-oeiiceio ae?oe a?ae 1 aei 3 ?ie?a - o ieo oyaee? oneeaaeiaiiy a?aei?/aeenue i?e iaioiio cieaeaii? eiai ai?noo. Aea/aiiy ei?aeyoeaieo aca?iia?aeiinei aeyaeei i?yiee ei?aeyoeaiee ca'ycie i?ae ai?noii a e?ia? a1-oeiiceio ? ??aiai CD3 – e?ioioeeo?a (r=+0,695), CD4 – ee?oeaie (r=+0,763), cai?ioio – c eiioeaio?aoe??th Oe?E (r=- 0,58). Noai aaiinoaco oa i?e?ioee?eoeyoe?? o oai?eo ia oyaee? oa oneeaaeiai? oi?ie ei?o Ci?ie aaiinoaco o 73,2% oai?eo ia oneeaaeiaiee e?? aeyaeyeenue o?iiaioeeoiiai??th, c?inoaiiyi aa?aaaoe?? ? aaeaaceaiino? o?iiaioeeo?a. ?o iieacieee iiaeooue aeei?enoiaoaaoeny, ye e?eoa??? i?iaiicoaaiiy oneeaaeiaiiai ia?aa?ao. Ae?aci?noue o?iiaioeeoa?ii-noaeeiieo ci?i caeaaeaea a?ae oa?aeoa?o oneeaaeiaiue. Iaea?eueo? cnoae ca?a?no?iaai? o oai?eo c iiaaiii??th, iaio? - i?e ?icaeoeo ea?eiaio?aoa?oo ? a?iio?oo. Aeyaeaii ei?aeyoe?ei?e ca’ycie i?ae e?euee?noth o?iiaioeeo?a ? ai?noii Oe?E (r=-0,752), i?ae aaeaaceaiinoth o?iiaioeeo?a ? ??aiai OoA2 (r=+0,627). O 71,4% oai?eo c oyaeeei oa oneeaaeiaiei ia?aa?aii ei?o a?aei?/aeenue cia/i? ci?ie eiaaoeyoe?eii? eaiee aaiinoaco: a?eueo ei?ioeee /an cai?oaiiy e?ia?, /an ?aeaeueoeeo?eaoe?? ieacie, c?inoaiiy i?io?iiaeiiaiai ?iaeaeno, a oaeiae eiioeaio?aoe?? a e?ia? o?a??iiaaio, ui a oe?eiio na?ae/eei i?i ?icaeoie noaio a?ia?eiaaoeyoe??. I?yiee ei?aeyoe?eiee aca?iica’ycie onoaiiaeaiee i?ae eiioeaio?aoe??th o?a?eiiaaio ? ai?noii o?iiaienaio (r=+0,674), cai?ioi?e - ai?noii i?inoaoeeee?io (r=-0,692). Aea/ai? iieacieee i?e aeienoe? ?c noaoe?iia?o ia ii?iae?coaaeenue. A nenoai? i?e?ioee?eoeyoe?? o oai?eo ia e?? ia?aaaaeaee ia?eaaneoey?i? ?iceaaee. I?aeaeuaiiy i?iieeiino? noaeei noi?iaiaeaeoaaeinue ?icaeoeii iaa?yeo, o 83,5% iaeeie/ieie aai iiiaeeiieie iicanoaeeiieie i?e?iaaii?aa?yie. I?e oeueiio, iieaciee E?3, yeee oa?aeoa?eco? nooi?iue iicanoaeeiieo ii?ooaiue, aeinoia??ii c?inoaa. I?e E?3, yeee ia?aaeuo? a 1,5 ?ace ? a?eueo na?aaei? ii?iaoeai? cia/aiiy, ?nio? iiaeeea?noue aeieeiaiiy oneeaaeiaiue. Aioo??oiueinoaeeii? ?iceaaee (E?2) i?iyaeyeenue oiia?eueiaiiyi aai coieieith e?iaiieeio, ?icaeoeii neaaeae-neiae?iio I-III nooiaiy a aaioeao ? eai?ey?ao, ciaioaii? e?eueeino? ooieoe?iioth/eo eai?ey??a c ooai?aiiyi a ?yae? aeiaaee?a aaaneoey?ieo cii. Noaeeii? ci?ie (E?1) a aino?iio ia??iae? ei?o oa?aeoa?ecoaaeenue caoaeaiiyi a?oa??ie ? aeeeaoaoe??th aaioe, cieaeaiiyi a?oa??iei-aaioey?iiai eiao?oe??ioo aei 1:4 - 1:5, oi?ioaaiiyi a?oa??iei-aaioey?ieo aianoiiic?a. Aiane?aeie oeueiai, E?0 yeee oa?aeoa?ecoaaany noeoii?noth i?e?ioee?eoeyoi?ieo ?iceaae?a cia/ii c?inoaa. Onoaiiaeaii i?yiee ei?aeyoeaiee ca’ycie i?ae iieacieeaie E?1 ? ??aiai na?aaeiueiiieaeoey?ieo Oe?E (r=+0,695); E?0 oa eiioeaio?aoe??th caaaeueieo Oe?E (r=+0,737); i?ae E?1 e IAA2/IAF2a (r=+0,738), E?0 oa ??aiai OoA2 (r=+0,725). Cai?ioia aca?iicaeaaei?noue a?aei?/aia i?ae cia/aiiyi E?0 ? ai?noii CD3 ee?oei (r=-0,654), i?ae E?3 ? e?euee?noth CD4 e?ioioeeo?a (r=-0,705), i?ae E?0 ? eiao?oe??ioii 6-eaoi-F1a/OoA2 (r=-0,691). Aeyaeai? ei?aeyoe?ei? ca’ycee na?ae/aoue i?i aca?iiiaoiiaeai?noue ?ioiieo, a?io?i?/ieo ? i?e?ioee?eoeyoi?ieo ii?ooaiue. Iaeneiaeuei? cnoae ?a?no?oaaeenue o oai?eo ia oyaeeee ? oneeaaeiaiee e??. Aoaeoeai?noue aioeieneaeaio?a, oeiiaaeneio oa eaoa?iio o eiiieaeniiio e?eoaaii? ei?o. Aeyaeai? iniaeeaino? ia?aa?ao na?aaei?oyaeei? oi?ie ei?o, ui iieyaaee o iii??ii ae?aaeaiiio ?ioieneeaoe?eiiio neiae?ii? oa eiiiainiaaieo ci?iao ?ioiiiai noaoono, a?io?i?/ieo iieaciee?a coiiaeee aeeth/aiiy a e?eoaaeueiee eiiieaen ae?oae oieioa?ieo aoeaoaoo oa anei?a?iiai? eeneioe. Eiia?iaoe?th aioeieneaeaio?a per os io?eioaaee 56 ae?oae, ye? neeaee ? iniiaio a?oio. Anei?a?iiaa eeneioa i?ecia/aeanue 59 ae?oyi ?? iniiaii? a?oie. A ??? iniiaio a?oio oa?eoei 61 /ieia?e, ye? io?eioaaee ie?aii oieioa?ie aoeaoao. A?oio ni?anoaaeaiiy (eiio?ieueio) neeaee 65 ae?oae. sse iieacaee aeine?aeaeaiiy, iaeii/ania i?ecia/aiiy i?e?iaeieo aioeieneaeaio?a ia oii? aacenii? oa?ai?? i?eaiaeeei aei ?aaeoeoe?? o oai?eo na?aaei?oyaeeith oi?iith ei?o ee?i?/ieo i?iya?a oai?iae ? nei?i/aiiy oa?i?io ia?aaoaaiiy a noaoe?iia??. A iniiai?e a?oi? a?aei?/aii nei?i/aiiy a 2,3 ?ace /anoioe oneeaaeiaiue: a?iio?oo a 3,3 ?ace, ioeo?a oa ea?eiaio?aoa?oo a 2,2 ?ace, aia?ie a 1,7 ?ace. Io?eiaiee ee?i?/iee aoaeo aeacaiiai e?eoaaiiy i?aeoaa?aeaeaiee aeine?aeaeaiiyi aeeiai?ee ?ioiieia?/ieo iieaciee?a. A?aeiiaethaaiiy ??aiy ?ioiieo iieaciee?a niinoa??aaeinue o 83 (71,6%) oai?eo. Iiceoeaiei ci?iai ?ioii?aaeoeaiino? ni?eyei a?aeiiaethaaiiy iaoaaie?/ieo i?ioean?a. I?eai?/aiiy i?ioean?a IIE i?ae aieeaii oieioa?ieo aoeaoaoo ? anei?a?iiai? eeneioe noi?iaiaeaeoaaeinue cieaeaiiyi iieaciee?a eiioeaio?aoe?? “NI”. Aeine?aeaeaiiy aeicaieeee anoaiiaeoe ni?eyoeeaee aieea i?e?iaeieo aioeieneaeaio?a ia iaoaaie?ci a?ao?aeiiiai? eeneioe, ? ye iane?aeie, i?e?ioee?eoeyoe?th oai?eo. Ie?aia i?ecia/aiiy oieioa?ieo aoeaoaoo aai anei?a?iiai? eeneioe aoei iaio aoaeoeaiei, ?acoeueoaoii /iai /anoioa oneeaaeiaiue aoea a?aeiia?aeii ia 35,2% oa 44% a?eueoith i?ae i?e noi?niiio canoinoaaii? (?en.3). ?en.3 Aoaeoeai?noue ??ciiai e?eoaaiiy o ae?oae na?aaeiueioyaeeith oi?iith ei?o Aeeth/aiiy a eiiieaen oa?aiaaoe/ieo caoiae?a i?e ei?o oieioa?ieo aoeaoaoo ? anei?a?iiai? eeneioe ni?eyei ciaioaiith ye ieoiii? aaae, oae ? ae?aco i?e?ioee?eoeyoi?ieo ii?ooaiue. Oae, a ? iniiai?e a?oi? ii?iae?ciaoaaany a?oa??iei-aaioey?iee eiao?oe??io. Caiono?aaiiy eai?ey??a ? caeeoeia? aaaneoey?i? ciie a?aecia/ai? a 30,4% aeiaaee?a, ia??aiii??i?noue eae?a?o oa caeo?noue i?e?inoaeei - a 37,5%. I?e oyaee?e oi?i? ei?o iaie ii?yae c eiia?iaoe??th -oieioa?ieo aoeaoaoo ? anei?a?iiai? eeneioe aeei?enoaiith per os o 38 ae?oae (?? iniiaia a?oia) aoa aei?iaoaaiee a?o/eciyiee i?aia?ao eaoa?ii, yeee io?eioaaee 37 /ieia?e (??? iniiaia a?oia) a aeiaia?e aeic? 10 000 II/ea aioo??oiueii’yciai. Aea/aia oaeiae aoaeoeai?noue ia?aioa?aeueiiai aaaaeaiiy oieioa?ieo aoeaoaoo ? anei?a?iiai? eeneioe ia oe? ?aiiuei? aeaoieneeoth/i? oa?ai?? o 36 ae?oae oai?eo ia e?? (? iniiaia a?oia). A?oio c?noaaeaiiy neeaee 42 aeeoeie oiai ae a?eo c oyaeeei ia?aa?aii caoai?thaaiiy, ye? io?eioaaee aacenio oa?ai?th. Ia?aioa?aeueia canoinoaaiiy oieioa?ieo aoeaoaoo ? anei?a?iiai? eeneioe ia oe? ?aiiuei? aeaoieneeaoe?eii? oa?ai?? a eiiieaeni?e oa?ai?? aeicaieeei i?aeaeueoe ee?i?/io aoaeoeai?noue e?eoaaiiy ae?oae, a naia ciaioeoe o?eaae?noue ?ioieneeaoe?? a 2,7 ?ace, ?ani??aoi?ieo ?iceaae?a a 1,9 ?ace, ciaioeoe /anoioo oi?ioaaiiy iiaaiii?e a 3,3 ?ace. E??i oiai, o ae?oae ii?iae?coaaeeny iieacieee ye ee?oeiieo, oae ? aoii?aeueieo oaeoi??a ?ioi?oaoo (?en.4). ?noioiee ?aa?an ?ioiieia?/ieo ci?i na?ae/eoue i?i oa, ui eiia?iaoe?y i?eaiaeeoue aei oaeaeei? ae?i?iaoe?? caoaeieea c i?aai?cio. Aeei?enoaiiy i?aia?ao?a ye noeioeyoi??a neioaco ?a/iaei c oeiiceiiiiae?aiith aeoeai?noth i?eaiaeeei aei c?inoaiiy ai?noo a1-oeiiceio Aeeth/aiiy eaoa?iio a e?eoaaeueiee eiiieaen aeyaeeiny ?acoeueoaoeaiei i?e canoinoaaii? a eaoa?aeueiiio ia??iae? ? a ia?oee aeaiue ia??iaeo aeneio. O 11 (29,7%) ae?oae aoee iia?/i? aoaeoe oa aea?a?/i? ?aaeoe??. ?en.4 Aoaeoeai?noue ??ciiai e?eoaaiiy o ae?oae oyaeeith oi?iith ei?o Iii??i? ci?ie ?ioiiiai noaoono i?e na?aaeiueioyaee?e oi?i? ei?o o aei?ineeo, a oaeiae i?aaiaiiy aeiaeoeny iioeiaeueii? iaoaaie?/ii? ei?aeoe?? aeyaeaieo ii?ooaiue ni?eyei aea/aiith oa?aiaaoe/ieo aeanoeainoae aioeieneaeaioo aio?aey i?e oe?e oi?i? oai?iae o 44 /ieia?e. Anoaiiaeaii, ui aio?aeue iii??ii aieeaa? ye ia ee?i?/i? oae ? ?ioiieia?/i? iieacieee. Oae, e?euee?noue CD3 -e?ioioeeo?a o 65,9% ethaeae aeinyaaea iieaciee?a o?c?ieia?/ii? ii?ie, o ?ioeo niinoa??aaeinue cia/ia iie?ioaiiy. Aaniethoia /enei CD4-e?ioioeeo?a a?aeiiaethaaeiny aei 0,96±0,058. Aeei?enoaiiy aio?aey i?eaiaeeei aei oaeaeeiai a?aeiiaethaaiiy ie?aieo eiiiiiaio?a nenoaie ia?ieneaeaoe??. A?aeaoaaeiny cieaeaiiy eiioeaio?aoe?? IAeA ? AeE. Ii?iae?caoe?y nenoaie aioeia?aeeniiai caoenoo aeyaeyeany a cieaeaii? eaoae?oe/ii? aeoeaiino? eeth/iaeo oa?iaio?a - eaoaeace (20,0±1,0 ieao/ae) ? NIAe (4,2±0,2 oi.iae/ie). Niinoa??aaany iiceoeaiee aieea ia aeeiai?eo i?inoaaeaiaeei?a, ii?i?aeieo iaioeae?a, i?e?ioee?eoeyoe?th (?en.5). ?en.5 Aoaeoeai?noue ??ciiai e?eoaaiiy o aei?ineeo na?aaeiueioyaeeith oi?iith ei?o Ine?eueee i?e oyaee?e oi?i? ei?o o aei?ineeo niinoa??aathoueny aeeaie? ?ioii? oa iaoaaie?/i? cnoae, ie aeei?enoaee eiia?iaoe?th aio?aeth c oeiiaaeneiii aeey e?eoaaiiy 33 oai?eo, ye? neeaee ? iniiaio a?oio.Ie?aia i?ecia/aiiy aio?aeth oa oeiiaaeneio i?e oyaee?e oi?i? ei?o o aei?ineeo aoei aeei?enoaii o 31(?? iniiaia a?oia) oa 34 (??? iniiaia a?oia) /ieia?e a?aeiia?aeii. Eiio?ieueio a?oio neeaee 35 /ieia?e a e?eoaaii? yeeo oe? i?eia?aoe ia aeei?enoiaoaaeeny. I?ae aieeaii eiia?iaoe?? i?aia?ao?a nei?i/oaaany ?icaeoie iiaaiii?e a 2,2 ?ace, a?iio?o?a - a 2,7 ?ace, aia?i - a 1,8. Ii?yae c ee?i?/iei iie?ioaiiyi a?aei?/aany ae?aaeaiee ?ioiiiiaeoethth/ee aoaeo. C?inoaea e?euee?noue O-e?ioioeeo?a, a?aei?/aeanue /?oea oaiaeaioe?y aei ii?iae?caoe?? ?o noaiiioeyoe?eiiai neeaaeo, cieaeaiiy ??aiy na?aaeiuei- oa ae??aiiiieaeoey?ieo Oe?E. Canoinoaaiiy eiia?iaoe?? iiceoeaii aieeaaei ia ooieoe?iiaeueio aeoeai?noue IE ? oaaioeeo?a. O oeeo oai?eo a??ia?aeii c?inoaee i?a?aoe?ei? ?iaeaene ?AIE, ui na?ae/eei i?i ciaioaiiy ?ioaineaiino? aooi?ioiieo ?aaeoe?e (?en.6). ?en.6 Aoaeoeai?noue ??ciiai e?eoaaiiy o aei?ineeo oyaeeith oi?iith ei?o Eiia?iiaaia i?ecia/aiiy oeiiaaeneio oa aio?aey ni?eyei e?ea?aeaoe?? neiae?iio “iaoaaie?/ii? ?ioieneeaoe??”, iie?ioaiith iieaciee?a ii?i?aeieo iaioeae?a. E?eoaaiiy i?ecaiaeeei aei ii?iae?caoe?? a1-oeiiceio o 80% oai?eo.O ?ioeo ai?no aa?iiioiaa /?oei ae?aaeaio oaiaeaioe?th aei iie?ioaiiy. Iiceoeaia aeeiai?ea i?e?ioee?eoeyoi?ieo cnoa?a noi?iaiaeaeoaaeanue ci?iith ?aieia?/ieo aeanoeainoae e?ia?. Ii?iae?coaaany /an eiaaoethaaiiy e?ia?, ?aeaeueoeeo?eaoe?? ieacie. Oaeei /eiii, canoinoaaiiy aeaieo i?aia?ao?a aeicaiey? iioei?coaaoe e?eoaaiiy, ui caaacia/o? ia o?eueee nei?i/aiiy no?ie?a e?eoaaiiy, aea ae cia/ii cieaeo? /anoioo ?icaeoeo oyaeeeo oi?i ? iiia?aaeaeo? oneeaaeiaiee ia?aa?a ei?o. AENIIAEE 1. Na?aae ianoaaeaieo oai?eo ia e?? oneeaaeiaiiy niinoa??aaeenue o 34,4% ae?oae ? 15,2% aei?ineeo. Iae/ano?oeie oneeaaeiaiiyie aoee o?aaeaiiy i?aai?a aeeoaiiy (42,3% o ae?oae ? 25,6% o aei?ineeo). Na?aae ?ioeo oneeaaeiaiue ?a?no?oaaeenue: aia?ie – o 14,0% ae?oae ? o 8,1% aei?ineeo, noiiaoeoe a?aeiia?aeii – 7,9% ? 10,7%, eii'thieoea?oe – 7,9% ? 7,2%, ioeoe – 6,6% ? 6,3%, neio?oe – 2,5% ? 0,9%, ea?aoeoe - 2,0% ? 0,9%, iai?ia?oe – 1,0% ? 1,3%, aioeaoae?oe – 1,0% ? 0,9%. Aioa?eoe iaee i?noi o 7,1% ae?oae, o aei?ineeo ia cono??/aeenue. 2. Iaea?eueo cia/oueie oaeoi?aie ?eceeo ?icaeoeo oneeaaeiaiue i?e ei?o o ae?oae, ? ianooii? ee?i?ei-aiaiianoe/i? iieacieee: ?iceaaee oa?/oaaiiy, aa?oai?iic ??-??? nooiaith, /ano? ?ani??aoi?i? caoai?thaaiiy, o?ii?/ia a?iioieaaaiaaa iaoieia?y, a?aenooi?noue aaeoeeiaoe??, a?e aei o?ueio ?ie?a, oyaeea oi?ia oai?iae; o aei?ineeo: ia??iae ?aeiiaaeanoeaioe?? ?ioeie ?ioaeoe?eieie caoai?thaaiiyie, o?ii?/ia iaoieia?y iiniaeioee, caoai?thaaiiy aeeoaeueii? nenoaie, ceiaaeeaaiiy aeeiaieai oa othothiiaa caeaaei?noue, o?eaaeee eiioaeo c i?ioan?eieie oe?aeeeainoyie. 3. ?ioiieia?/ia iaaeinoaoi?noue o oai?eo ia e?? c oneeaaeiaiei ia?aa?aii oai?iae i?iyaey?oueny e?ioiiai??th, cieaeaiiyi ??aiy caaaeueii? iiioeyoe?? O-e?ioioeeo?a, e?eueeino? O-oaeia??a/?iaeoeoi??a, a oaeiae a ie?aieo aeiaaeeao A-e?ioioeeo?a (ia?aaaaeii o ae?oae o a?oe? aei 3-o ?ie?a), ciaioaiiyi iieaciee?a OAI, i?aeaeuaiiyi ??aiy Oe?E a e?ia? ca ?aooiie iaea?eueo iaoiaaiieo na?aaeiuei- ? ae??aiiiieaeoey?ieo ?ioiieo eiiieaen?a, aeec?ioiiaeiaoe?iai??th. Anoaiiaeaii aca?iica’ycie i?ae ?ioiieie iieacieeaie oa aioeaaiaie nenoaie HLA. O oai?eo c oneeaaeiaiiyie aei iiiaioo aeienee ia a?aei?/a?oueny a?aeiiaeaiiy iieaciee?a ?ioi?oaoo. 4. Oyaee? ? oneeaaeiai? oi?ie ei?o, ye? ?icaeaaeenue ia iani?eyoeeaiio i?aii?a?aeiiio oii? oa?aeoa?ecothoueny cia/iei ? aeiaaio?eaaeei cieaeaiiyi i?iaeoeoe?? a1-oeiiceio, ui na?ae/eoue i?i ae?aaeaio i?ieiiaiaaio iaaeinoaoi?noue ooieoe?? aeei/eiai? caeice ? ca?aa?oueny c oi?ioaaiiyi ?ioiiaeao?oeeoieo noai?a. 5. Onoaiiaeaii aca?iica’ycie aeoeaiino? IIE c ?ioaineai?noth ?ioiieo i?ioean?a ? ee?i?/ieie iniaeeainoyie ei?o. Aeeneii?aeeiaoe?y nenoaie “ia?aeenia ieeneaiiy e?i?ae?a - aioeieneaeaioe” e?ia? o oai?eo c oneeaaeiaiei ia?aa?aii oai?iae ae?aaea?oueny a nooo?aiio c?inoaii? aeoeaiino? i?ioean?a IIE ?, a ?acoeueoao? aeanoaa?e?caoe?? ee?oeiieo iaia?ai, aeoiae? a ne?iaaoeo e?ia? oa?iaio?a aioeia?aeeniiai caoenoo, ui noi?iaiaeaeo?oueny iaeiie/aiiyi AeE, IAeA, iaaeinoaoiueith aeoeai?noth eaoaeace ? NIAe. 6. O oai?eo ia oneeaaeiaiee e?? aeyaeaiee neiae?ii “iaoaaie?/ii? ?ioieneeaoe??”, i?i ui na?ae/eoue c?inoaiiy e?eueeino? “na?aaei?o iieaeoe”; iaeneiaeueiiio ae?aco NI? a?aeiia?aea? a?eueo cia/ia i?aeaeuaiiy ??aiy i?iaeoeo?a IIE a ne?iaaooe? e?ia?. 7. A aino?iio ia??iae? ei?o a?aeaoaa?oueny aeoea?caoe?y oeyo?a ia?aoai?thaaiiy a?ao?aeiiiai? eeneioe, ui ae?aaea?oueny a c?inoaii? o e?ia? eiioeaio?aoe?e ?? iaoaaie?o?a (ToA2, 6-eaoi-IAF1a, IAA2, IAF2a, EOA4, EON4). Aeyaeaii ei?aeyoeaiee aca?iica’ycie i?ae ?ioiieie cnoaaie oa a?io?i?/ieie i?ioeanaie, ui i?aeoaa?aeaeo? ?ioiiaeai?aneaiee aieea ?a/iaei ci?iaiiai iaoaaie?cio. 8. I?e ?icaeoeo oneeaaeiaiue ei?o aeieeathoue cia/i? ci?ie iaoaaie?cio ii?i?aeieo iaioeae?a, ye? caaacia/othoue aeainoi?iii? ooieoe?iiaeuei? ca’ycee iae?iaiaeie?eiii? oa ?ioiii? nenoai. A ?iciae? oai?iae ia? i?noi cieaeaiiy eiioeaio?aoe?? b-aiaei?o?io, iao-aie?oae?io ? i?aeaeuaiiy ??aiy eaeaie?oae?io. 9. E?? a aino?iio ia??iae? noi?iaiaeaeo?oueny ii?ooaiiyie nenoaie i?e?ioee?eoeyoe??, ye? iieyaathoue a ci?i? eae?a?o i?e?inoaeei, i?iieeiino? noaeeiii? no?iee, ii?ooaiiyie oaeaeeino? ? oa?aeoa?o e?iaiieeio, iayai?noth ia?eaaneoey?ieo ?iceaae?a. ?o ae?aci?noue ? o?eaae?noue ca’ycai? c oyaee?noth ? oa?aeoa?ii ia?aa?ao ei?o, ui iiaea aooe aeei?enoaii ye e?eoa??? i?iaiico oneeaaeiaiue. Onoaiiaeaiee aca?iica’ycie i?e?ioee?eoeyoi?ieo ii?ooaiue c iaoaaie?/ieie oa ?ioiieie iieacieeaie. 10. Eaai?aoi?i? iieacieee, ye? iiaeooue aooe aeei?enoai? aeey i?iaiicoaaiiy oneeaaeiaiue ? ?ioiieia?/i? (o ae?oae ? aei?ineeo a?aeiia?aeii): cieaeaiiy a aino?iio ia??iae? e?eueeino? ND3 ee?oie aei 35% ? 45%, ni?aa?aeiioaiiy ND4/ND8 aei 1,3 ? 1,0, i?aeaeuaiiy ??aiy Oe?E 3,2 a/e ? 4,5a/e, i?aeaeuaiiy ?AIE aei OA aei 0,9 ? 0,6; a?io?i?/i?: i?aeaeuaiiy ??aiy IAeA aei 41,5ieiieue/e ? 61,0ieiieue/e, cieaeaiiy ni?aa?aeiioaiiy 6-eaoi-IAF1/OoA2 aei 0,7 ? 1,0, i?aeaeuaiiy ni?aa?aeiioaiiy IAF2a/IAA2 aei 3,0 ? 3,5, cieaeaiiy ??aiy a1-oeiiceio aei 1,0 ia/ie ? 0,4ia/ie. 11. Aeeth/aiiy a e?eoaaiiy ei?o aioeieneaeaio?a (anei?a?iiai? eeneioe oa oieioa?ieo aoeaoaoo o ae?oae, aio?aeth o aei?ineeo) ni?ey? a?eueo oaeaee?e e?ea?aeaoe?? neiae?iio “iaoaaie?/ii? ?ioieneeaoe??”. Ciaioaiiy /anoioe oneeaaeiaiue (a 2,3 ?ace o ae?oae ? 1,5 ?ace o aei?ineeo) aeicaiey? aeei?enoiaoaaoe i?aia?aoe aeey ?o i?io?eaeoeee.. I?e iayaiino? ae?acieo ?ioiieia?/ieo ii?ooaiue iieacaii aeeth/aiiy a eiiieaenio oa?ai?th oai?eo ia e?? i?aia?ao?a oeiona ia oii? aioeaaeoa??aeueii? oa?ai??. Canoinoaaiiy eaoa?iio o ae?oae aoei iaio aoaeoeaiei ? noi?iaiaeaeoaaeinue a 29,7% iia?/ieie ?aaeoe?yie. NIENIE IIOAE?EIAAIEO I?AOeUe 1. A?oiaa E.A. Ei?ue (eeeieea e iaoiaaiac). – Eoaaine: Ecae-ai EAIO, 1997. – 231 n. (iiiia?ao?y). 2. ??oiaa ?.A. Ee?i?ei-?ioiieia?/ia oa?aeoa?enoeea ei?o a aei?ineeo ? ae?oae c oneeaaeiaiiyi ia?aa?ao oai?iae // ?ioaeoe?ei? oai?iae. – 1995. - ? 1. – N. 47-48. 3. A?oiaa E.A., Iao?oiy A.I. Ii?aaeaiea aeac o aieueiuo ei?ueth // Iooaeueiieiae/aneee aeo?iae.- 1996. - ? 5-6. - N. 345-346. 4. A?oiaa E.A. Ooieoeeiiaeueiay aeoeaiinoue eaeeioeeoia e ia?aeeniia ieeneaiea eeieaeia o aieueiuo i?e ei?e, ineiaei?iiie iiaaiiieae // Eiioiieiaey.-1997.-?6.- N.59-60. 5. A?oiaa E.A. Yooaeoeaiinoue oeiiaaeneia i?e ?acee/iuo oi?iao ei?e // Cae?aaiio?aiaiea Aeiiaanna.- 1997.- ? 1.- N.53-56. 6. A?oiaa E.A. EI? - iaoieiaey i?e ei?e o aeaoae // AEo?i.aooi.iinia. ? ai?eiaeo oai?ia.- 1997.-? 2.-N.62-64. 7. ??oiaa ?.A. Noai i?e?ioee?eoeyoe?? o oai?eo ia e?? // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1997. - ? 1.-N.26-27. 8. ??oiaa ?.A. Iaa?ieia?/i? oneeaaeiaiiy ei?o o ae?oae // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.- 1997.-? 4.- N.28-29. 9. ??oiaa ?.A. Caoai?thaaiiy ia e?? ae?oae uaieaieo a ??ci? ia??iaee ?ieo // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.- 1997.-?6.- N.65-66. 10. A?oiaa E.A. Eeeieei-eiioiieiae/aneay ioeaiea i?eiaiaiey oeiiaaeneia i?e ?acee/iuo oi?iao ei?e // A?a/aa. aeaei.- 1997.- ? 6. – N. 147-149. 11. A?oiaa E.A. Aeai?eoi i?iaiice?iaaiey ineiaei?iiuo oi?i ei?e// E?ea?nueea ni?aaa.-1998.-?6.- N.69-72. 12. THuoe I.Ae., O?ieia A.I., A?oiaa E.A. Annioeeaoeey aioeaaiia HLA eeannia I e II n caaieaaaaiinoueth ei?ueth // AEo?iae iee?iaeieiaee, yieaeaieieiaee e eiioiieiaee.- 1998.-?3.-N.55- 57. 13. A?oiaa E.A. Iiuo i?eiaiaiey aiieneeeaaa e oeiiaaeneia i?e ei?e, ineiaeieaoaeny ino?ui n?aaeiei ioeoii o eeoe, /anoi aieathueo ino?uie ae?oniuie eioaeoeeyie // AEo?i.aooi.iinia. ? ai?eiaeo oai?ia.-1998.-?2.-N.56-58. 14. A?oiaa E.A., A?euaiei I.A., Iuoeiaa A.N. Nia?aiaiiua iaoiaeu aeeaaiinoeee ei?e a i?aeoeea iaaeeao?a // Iaaeaeoia?iaeiue iaaeeoeeineee aeo?iae. - 1998. - ?2. - N.133-136. 15. A?oiaa E.A., Oea/aiei I.O. I?iaiice?iaaiea ineiaeiaiee i?e ei?e // Iaaeaeoia?iaeiue iaaeeoeeineee aeo?iae. - 1999. - ?2. - N.112-114. 16. ??oiaa ?.A. Ee?i?ei-iaoiaaiaoe/ia cia/aiiy ii?ooaiue ?ioiiiai noaoono i?e ei?o a ae?oae oa eiai ei?aeoe?y // Oe?a?inueeee iaaee/iee aeueiaiao.-1998.-?1.-N.37-40. 17. ??oiaa ?.A. I?inoaaeaiaeeie a iaoiaaiac? ei?o // Oe?a?inueeee iaaee/iee aeueiaiao.-1998.-?4.-N.45-47. 18. A?oiaa E.A., A?oeiia A.TH. Niaea?aeaiea aeueoa 1- oeiiceia o aieueiuo ei?ueth // Eaai?aoi?iay aeeaaiinoeea.- 1999.-?2.-N.6-10. 19. ??oiaa ?.A. Ee?i?ei-iaoiaaiaoe/i? iniaeeaino? ei?o a no/anieo oiiaao // Aeeoy/? ?ioaeoe??: Oe?a?inueea i?aea?aeii/a ca??ea. – Aei. 23. - Ee?a, 1995. - N. 118-124. 20. ??oiaa ?.A. Aioeieneaeaioia oa ?ioiia ei?aeoe?y a e?eoaaii? oai?eo ia ei?aao iiaaiii?th // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?ie/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue.- Ee?a-Eoaainuee.- Aeione 1, 1997.- N.51-54. 21. A?oiaa E.A. Eiioiieiae/aneea iieacaoaee o aieueiuo ei?ueth // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue.- Ee?a-Eoaainuee.- Aeione 1, 1997.-N.60-63. 22. A?oiaa E.A. Acaeiiaeaenoaea oeeeeaciie e eiioiiie nenoai o aieueiuo ei?ueth // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?ie/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue.- Ee?a - Eoaainuee, Aeione 2, 1997.- N.48-52. 23. A?oiaa. E.A. Ooieoeeiiaeueiay aeoeaiinoue oeiona o aieueiuo ei?ueth // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?ie/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue.- Ee?a - Eoaainuee, Aeione 2, 1998.- N.64 - 73. 24. A?oiaa E.A. Aeeyiea oeeeee/aneeo ioeeaioeaeia ia eiioiiua iieacaoaee o aieueiuo ei?ueth // Aeooaeuei? i?iaeaie aeooa?noaa ? a?iaeieia??, ee?i?/ii? ?ioiieia?? oa iaaee/ii? aaiaoeee: Ca??iee iaoeiaeo i?aoeue.- Aei. 2. – Ee?a – Eoaainuee, 1998. – N.225-230. 25. A?oiaa E.A., A?euaiei I.A., Cai/aiei A.I., Aiiaea?aiei A.A., Oeeei A.N. Oa?aeoa? eiioiieiae/aneeo eciaiaiee i?e ei?e e eo ?ieue a eeeieea aieacie // Aeooaeuei? i?iaeaie aeooa?noaa ? a?iaeieia??, ee?i?/ii? ?ioiieia?? oa iaaee/ii? aaiaoeee: Ca??iee iaoeiaeo i?aoeue.- Aei. 3. – Ee?a – Eoaainuee, 1999. – N.156-163. 26. A?oiaa. E.A. Oano nenoaia aeey ?aiiae aeeaaiinoeee ei?e // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?ie/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue.- Ee?a - Eoaainuee, Aeione 3, 1999.- N.179 - 183. 27. ??oiaa ?.A. I?iaiic oneeaaeiaiue ei?o // Aeeoy/? ?ioaeoe??: Oe?a?inueea i?aea?aeii/a ca??ea. – Aei. 25. - Ee?a, 1999. - N. 110-118. 28. A?oiaa E.A. Eeeie/aneea iniaaiiinoe oa/aiey ei?e o i?eaeouo e iai?eaeouo aeaoae // Aeooaeuei? i?iaeaie aeieia?/ii? oa ee?i?/ii? ?ioiieia??: Iaoa?. II iaoe. Neiiic?oio. – Ee?a-Eoaainuee, 1994.- N. 20. 29. A?oiaa E.A. I?iaiinoe/aneia cia/aiea eiioiieiae/aneeo iieacaoaeae a ?acaeoee ineiaeiaiee o aieueiuo ei?ueth e aao?yiie iniie //Aeooaeuei? i?iaeaie aeieia?/ii? oa ee?i?/ii? ?ioiieia??: Iaoa?. II iaoe. Neiiic?oio. – Ee?a-Eoaainuee, 1994.- N. 21. 30. A?oiaa E.A. Eiioiieiae/aneea iieacaoaee o aeaoae n oyaeaeie e ineiaei?iiie oi?iie ei?e // Aeieia?y, ?ioi?oao oa caei?ia’y ianaeaiiy: Iaoa?. ?anioae. Nai?ia?o. – Ee?a-Eoaainuee, 1994. - N. 16. 31. A?oiaa E.A. Oee?eoee?othuea eiioiiua eiiieaenu e aooieiioiiay iaoieiaey o aieueiuo ei?ueth // Aeieia?y, ?ioi?oao oa caei?ia’y ianaeaiiy: Iaoa?. ?anioae. Nai?ia?o. – Ee?a-Eoaainuee, 1994. - N. 17. 32. A?oiaa E.A., Iaaeaaaeaaa A.A. ?ieue aooieiioiiuo naeaeaia a iaoiaaiaca oyaeaeuo e ineiaeiaiiuo oi?i ei?aaie eioaeoeee // Iaoa?. THaeeaeiie iao/.-i?aeoe/. eiio., iinayu. 100-eaoeth 4-e AA a.Eoaainea. – 1 oii. - Eoaaine, 1995. – N. 95. 33. A?oiaa E.A., Ooeue A.E. Ia?aeeniia ieeneaiea eeieaeia e aioeieneaeaioiay nenoaia e?iae o aeaoae, aieueiuo ei?ueth // Iaoa?. THaeeaeiie iao/.-i?aeoe/. eiio., iinayu. 100-eaoeth 4-e AA a.Eoaainea. – 1 oii. - Eoaaine, 1995. – N. 96. 34. A?oiaa E.A., Ei?iaea E.I. Ooieoeeiiaeueiia ninoiyiea ia/aie o aieueiuo ei?ueth // Iaoa?. THaeeaeiie iao/.-i?aeoe/. eiio., iinayu. 100-eaoeth 4-e AA a.Eoaainea. – 2 oii. - Eoaaine, 1995. – N. 44. 35. A?oiaa E.A. Anoanoaaiiue eiaeae?othuee oaeoi? o aieueiuo ei?ueth// Iaoa?. THaeeaeiie iao/.-i?aeoe/. eiio., iinayu. 100-eaoeth 4-e AA a.Eoaainea. – 2 oii. - Eoaaine, 1995. – N.43-44. 36. Iiia?aioeaaa O.E.,Iicaeiyeiaa E.A.,A?oiaa E.A. e ae?. Ninoiyiea ia?aioeiu ia/aie e iee?iaaiiaeeiaieee o aeaoae n iaieiaiyioeaoaeeoaie ia?ioeoiie e ei?aaie yoeieiaee// Iaoa?. THaeeaeiie iao/.-i?aeoe/. eiio., iinayu. 100-eaoeth 4-e AA a.Eoaainea. – 2 oii. - Eoaaine, 1995. – N. 55. 37. A?oiaa E.A. N?aaiaiea eeeie/aneiai oa/aiey e /anoiou ineiaeiaiee ei?e o i?eaeouo e iai?eaeouo aeaoae // Iaoa??aee O iaoeiaiai neiiic?oio “Aeooaeuei? i?iaeaie aeieia??, ee?i?/ii? ?ioiieia?? oa ?ioaeoe?eii? iaoieia??”.-Ee?a-Eoaainuee.-1995.- N.10-11. 38. A?oiaa E. A., Aaneaeia E.I. Aeeiaieea eiioiieiae/aneeo iieacaoaeae o aeaoae aieuei?o ei?ueth// Oaii ae.- N.41-42. 39. A?oiaa E.A. Oeeoiaaiaoe/aneea e iee?iaaiiaeeiaie/aneea ia?ooaiey o aieueiuo ei?ueth // Ineoiniiaoe/aneea ?anno?ienoaa: Iaoa?. Niaianoiie iao/iie nannee. – Oa?ueeia-Eoaaine, 1995. - N. 33. 40. Iiia?aioeaaa O.E., A?oiaa E.A. Eiioiiua e iaoaaiee/aneea ia?ooaiey o aieueiuo ei?aauie iaieiaiyioeaoaeeoaie // Ineoiniiaoe/aneea ?anno?ienoaa: Iaoa?. Niaianoiie iao/iie nannee. – Oa?ueeia-Eoaaine, 1995. - N. 79-80. 41. A?oiaa E.A. Eeeieei-eiioiieiae/aneay oa?aeoa?enoeea ei?aaiai yioeaoaeeoa o aeaoae // Caei?iauea ianaeaiey: nioeeaeueii-yeieiae/aneea aniaeou, i?aaiecaoeey iaaeeoeeineiai ianeoaeeaaiey: Iaoa?. Iao/.-i?aeoe/. eiio. – Eoaaine, 1995. - N. 49. 42. A?oiaa E.A. Eeeie/aneay oa?aeoa?enoeea ei?e o aeaoae a i?iiuoeaiiuo ?aaeiia Aeiiaanna // Caei?iauea ianaeaiey: nioeeaeueii-yeieiae/aneea aniaeou, i?aaiecaoeey iaaeeoeeineiai ianeoaeeaaiey: Iaoa?. Iao/.-i?aeoe/. eiio.– Eoaaine, 1995. - N. 50. 43. A?oiaa E.A., Oeeoiiaa O.A. Ooieoeeiiaeueiay aeoeaiinoue ei?u iaaeii/a/ieeia e iieiauo aeae?c o aeaoae, aieueiuo ei?ueth//Na. iao/iuo o?. nio?oaeieeia iaae. oi-oa e iaeanoiie aeaoneie eeeie/aneie aieueieoeu, iinayu. 75-eaoeth iaaeeao?e/aneie neoaeau Eoaaineie iaeanoe.-Eoaaine,1996.-N.315-317. 44. ??oiaa ?.A., Eineooiaa ?.A., Ei?iaea E.I., Iicaeiyeiaa ?.I. Ee?i?ei-?ioiieia?/i? iniaeeaino? ei?o o ae?oae, aaaeoeiaaieo ?c cii c iani?eyoeeaith ?aae?aoe?eiith ianoaiiaeith // Aeooaeuei? i?iaeaie i?e?ia?ieia??, ai?aeai?ieia??, ia?aceoieia?? oa i?io?eaeoeee ?ioaeoe?eieo oai?ia: Iaoa?. XIII c’?caeo Oe?a?inueeiai iaoeiaiai oia-aa i?e?ia?ieia?a, ai?aeai?ieia?a oa ia?aceoieia?a ?i. Ae.E.Caaieioiiai. Ee?a-A?iieoey, 1996. – N. 118-119. 45. Iiia?aioeaaa O.?., Iicaeiyeiaa ?.I., Eineooiaa ?.A., ??oiaa ?.A. I?e?ioee?eoeyoi?i? oa ?ioii? ii?ooaiiy o ae?oae c a??onieie iai?iaiaioeaoae?oaie ??cii? ao?ieia?? // Aeooaeuei? i?iaeaie i?e?ia?ieia??, ai?aeai?ieia??, ia?aceoieia?? oa i?io?eaeoeee ?ioaeoe?eieo oai?ia: Iaoa?. XIII c'?caeo Oe?a?inueeiai iaoeiaiai oia-aa i?e?ia?ieia?a, ai?aeai?ieia?a oa ia?aceoieia?a ?i. Ae.E.Caaieioiiai. Ee?a-A?iieoey, 1996. – N. 284-285. AIIIOAOeEss A?oiaa E.A. I?iaiice?iaaiea i?ioeeaeoeea e ea/aiea ineiaeiaiiuo oi?i ei?e. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.13 – eioaeoeeiiiua aieacie, Eeaaneee IEE yieaeaieieiaee e eioaeoeeiiiuo aieaciae ei. E.A. A?iiaoaaneiai, Eeaa, 1999. Aeenna?oaoeey aeeth/aao ?acoeueoaou eco/aiey eeeieee, iaoiaaiaca, i?iaiinoe/aneeo oaeoi?ia, i?ioeeaeoeee e ea/aiey ineiaei?iiuo oi?i ei?e. Ianeaaeiaaii 617 aieueiuo ec eioi?uo o 306 /aeiaae eiaeenue ?acee/iua ineiaeiaiey e o 311 oaeiaua ionoonoaiaaee. Auyaeaiu iniaaiiinoe i?aii?aeaeiiai oiia e eeeie/aneiai oa/aiey aieacie. Onoaiiaeaii, /oi ?acaeoeth ineiaeiaiee o aeaoae niinianoaotho: ?anno?ienoaa ieoaiey, aaeoaieiic ??-??? noaiaie, /anoua ?anie?aoi?iua caaieaaaiey, o?iie/aneay a?iioieaai/iay iaoieiaey, ionoonoaea aaeoeeiaoeee, aic?ano aei o??o eao, oyaeanoue oa/aiey aieacie; o ac?ineuo: ia?eiae ?aeiiaaeanoeaioeee ae?oaeie eioaeoeeiiiuie caaieaaaieyie, o?iie/aneay iaoieiaey iiniaeioee, caaieaaaiey aeuoaoaeueiie nenoaiu, ceioiio?aaeaiey aeeiaieai e ieeioeiiaay caaeneiinoue, aeeeoaeueiue eiioaeo n i?ioanneiiaeueiuie a?aaeiinoyie. Onoaiiaeaiu aeoaieea eciaiaiey iaoaaiee/aneeo iieacaoaeae: aeoeaaoeey ia?aeeniiai ieeneaiey eeieaeia e naeaeae a aioeieneaeaioiie nenoaia, ?ino o?iaiy “n?aaeieo iieaeoe”, iiauoaiea eiioeaio?aoeee i?inoaiieaeia e eaeeio?eaiia, ia?ooaiea iaiaia iae?iiaioeaeia, aeai?anney ooieoeee aeei/eiaie aeaeacu. Ia?a/eneaiiua eciaiaiey i?eaiaeyo e ia?ooaieth iae?iaoii?aeueiie ?aaoeyoeee eiioiiie nenoaiu e oi?ie?iaaieth neiae?iia “iaoaaiee/aneie eioieneeaoeee”. O aieueiuo n ineiaei?iiuie oi?iaie ei?e iaia?oaeaii cia/eoaeueiia oaiaoaiea eiioiiie nenoaiu: nieaeaiea iauaai o?iaiy eeioioeeoia, au?aaeaiiay O-eeioiiaiey, oiaiueoaiea eiioii?aaoeyoi?iiai eiyooeoeeaioa, eciaiaiea niaea?aeaiey A-eeioioeeoia, nieaeaiea eiee/anoaa e ooieoeeiiaeueiie aeoeaiinoe anoanoaaiiuo eeeea?ia, aeeneiioiiaeiaoeeiaiey, iiauoaiea niaea?aeaiey OeEE ca n/ao iaeaieaa iaoiaaiiie o?aeoeee n?aaeia- e iaeeiiieaeoey?iuo eiiieaenia, nieaeaiea oaaaoeeoa?iie aeoeaiinoe. Iaia?oaeaiu eciaiaiey iee?iaaiioee?eoeyoi?iuo ooieoeee. Noaiaiue au?aaeaiiinoe onoaiiaeaiiuo ?anno?ienoa caaeneo eae io oyaeanoe oa/aiey, oae e iaee/ey ineiaeiaiee. Auyaeaia acaeiiiaoneiaeaiiinoue aeaiiuo eciaiaiee a ieaia ?acaeoey ineiaei?iiuo oi?i ei?e. Ia iniiaa eco/aiiuo ia?aiao?ia auaaaeaiu i?iaiinoe/aneea iieacaoaee ?acaeoey ineiaeiaiee. I?eiaiaiea anei?aeiiaie eeneiou e oieioa?iea aoeaoaoa o aeaoae, aio?aey o ac?ineuo niinianoaoao iaeaieaa auno?iio ia?aoiiio ?acaeoeth eeeie/aneeo i?iyaeaiee ei?e, i?aaeoi?aaeaeaieth ?acaeoey ineiaeiaiee, ieacuaaao au?aaeaiiia eiioiinoeioee?othuaa e aioeieneaeaioiia aeaenoaea, aieaa yooaeoeaii iiaeaaeyao iaoaaieeci yeeicaiieaeia, niinianoaoao aieaa auno?iio oeo/oaieth iaiaia iieieaeiuo iaioeaeia, ainnoaiiaeaieth ooieoeee aeei/eiaie aeaeacu e ninoiyiey iee?ioee?eoeyoi?iiai ?onea. A neaaenoaee ?acei nieaeaiiiai o?iaiy a1-oeiiceia o ac?ineuo aieueiuo n ineiaei?iiuie oyaeaeuie oi?iaie ei?e, a oaeaea i?e iaee/ee au?aaeaiiuo eiioiieiae/aneeo ia?ooaiee iieacaii aeeth/aiea a eiiieaenioth oa?aieth aieueiuo ei?ueth i?aia?aoia oeiona (oeiiaaeneia) n ii?aaeaeaieai eiaeeaeaeoaeueiie /oanoaeoaeueiinoe e ieo eiioiioeeoia ia?eoa?e/aneie e?iae a oanoao in vitro. Eeth/aaua neiaa: ei?ue, aeaoe, HLA, eiioiiue aaiinoac, oa?iaiou, ia?aeeniia ieeneaiea eeieaeia, yeeicaiieaeu, iee?iaaiiaeeiaieea, oeiiaaenei, anea?aeiiaay eeneioa, oieioa?ie aoeaoao, eaoa?ii, ineiaeiaiey, i?iaiic. AIIOAOe?ss ??oiaa ?.A. I?iaiicoaaiiy, i?io?eaeoeea oa e?eoaaiiy oneeaaeiaieo oi?i ei?o. - ?oeiien. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.13 – ?ioaeoe?ei? oai?iae, Ee?anueeee IAe? ai?aeai?ieia?? ? ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai, Ee?a, 1999. Aeena?oaoe?y aeeth/a? ?acoeueoaoe aea/aiiy ee?i?ee, iaoiaaiaco, i?iaiinoe/ieo /eiiee?a, i?io?eaeoeee oa e?eoaaiiy oneeaaeiaieo oi?i ei?o. Ianoaaeaii 617 oai?eo c yeeo o 306 /ieia?e aoee ??ci? oneeaaeiaiiy ? o 311 oneeaaeiaiue ia aoei. Anoaiiaeaii, ui ?icaeoeo oneeaaeiaiue o ae?oae ni?eythoue: ?iceaaee aeeaeaiiy, aa?oai?iic ??-??? nooiaith, /ano? ?ani??aoi?i? caoai?thaaiiy, o?ii?/ia a?iioieaaaiaaa iaoieia?y, a?aenooi?noue aaeoeeiaoe??, a?e aei o?ueio ?ie?a; o aei?ineeo: ia??iae ?aeiiaaeanoeaioe?? ?ioeie ?ioaeoe?eieie caoai?thaaiiyie, o?ii?/ia iaoieia?y iiniaeioee, caoai?thaaiiy aeeoaeueii? nenoaie, ieeioeiiaa oa aeeiaieueia caeaaei?noue, o?eaaeee eiioaeo c i?ioan?eieie oe?aeeeainoyie. O oai?eo c oneeaaeiaieie oi?iaie ei?o anoaiiaeai? aeeaie? ci?ie iaoaaie?/ieo iieaciee?a: aeoeaaoe?y ia?aeeniiai ieeneaiiy e?i?ae?a oa c?ooaiiy a aioeieneaeaioi?e nenoai?, c?inoaiiy ??aiy “na?aaei?o iieaeoe”, i?aeaeuaiiy eiioeaio?aoe?? i?inoaii?ae?a ? eaeeio???i?a, ii?ooaiiy iai?io iae?iiaioeae?a, aeai?an?y ooieoe?? aeei/eiai? caeice. Aeyaeai? ci?ie i?e?iaaiioee?eoeyoi?ieo ooieoe?e. Ia?a?aoiaai? ci?ie i?eaiaeyoue aei ii?ooaiiy iae?iaoii?aeueii? ?aaoeyoe?? ?ioiii? nenoaie ? oi?ioaaiith neiae?iio “iaoaaie?/ii? ?ioieneeaoe??”. Ia iniia? aea/aieo ia?aiao??a aeaaaeai? i?iaiinoe/i? iieacieee ?icaeoeo oneeaaeiaiue. Aeeth/aiiy a oa?ai?th ei?o niieo/aiiy anei?a?iiai? eeneioe oa oieioa?ieo aoeaoaoo o ae?oae, aio?aey o aei?ineeo ni?ey? oaeaee?e e?ea?aeaoe?? ee?i?/ieo i?iya?a ei?o, iiia?aaeaeaiith ?icaeoeo oneeaaeiaiue, ni?ey? iie?ioaiith iaoaaie?cio. I?e iayaiino? ae?aaeaieo ?ioiieia?/ieo ii?ooaiue iieacaia aeeth/aiiy a eiiieaenio oa?ai?th oai?eo ia e?? i?aia?ao?a oeiona (oeiiaaeneio). SUMMARY Ershova I.B. The prognosis prevention and treatment of the complicated forms of a measles. - Manuscript. Competition dissertation for degree of the doctor of Medicine in speciality - 14.01.13 - Infectious Diseases, L.V. Gromashevskogo Scientific Research Institute of Epidemiology and Infectious Diseases, Kiev, 1999. The thesis includes the results of learning the clinic, pathogenesis, prognostic factors, prevention and treatment of the complicated forms of a measles. 617 ill people were inspected; amond them there were 306 patients who had various complications and at 311 patients who did not have them at all. It is established, that the development of children’s complications promote the following factors: disorders in nourishment, deficient in vitamin, frequents colds, pneumonia, absence of vaccination, age till three years, seriousness of current of illness; adults’: complications promote: the period of convalescence by other infectious diseases, chronic pathology of respiratory system, nicotin and alcoholic dependence, long contact with professional hazards. Deep changes of methabolic changes are established: activity of the process of lipid peroxide oxidation and shifts in the antioxidantive system, growth of a level "of average molecules", rise of eucosanoide concentration, violation of neuropeptids exchange. Listed changes lead to violation of neurohormone regulation of the immunity system and creation of a syndrome called "methabolic intoxication". On the basis of investigated parameters there were revealed the prognostic metrics of the development of complications. The application vitamin C and tocopheroli acectatis, anotral promotes the fastest return development of clinical manifestations of a measles, warning against development of complications. In consequence of a sharply reduced level a1-tymosin at adult with complicated heavy forms of a measles and also at presence of expressed immunological violations is shown the inclusion of the preparations of thymus in the complex of therapy, to people suffered from a measles. NIENIE NEI?I*AIUe AAE -a?ii?e?ineii?y aoeueaa?ii? eii’thieoeae AeE- ae??iia? eii’thaaoe ?Oe - ?iaeaen oeeoioiene/iino? E - eiao?oe??io a?aeiinii? i?aaaeiiiae?aiino? E?1- eii’thieoeaaeueiee ?iaeaen noaeeiieo ci?i E?2- eii’thieoeaaeueiee ?iaeaen aioo??oiueinoaeeiieo ci?i E?3- eii’thieoeaaeueiee ?iaeaen iicaaaneoey?ieo ii?ooaiue E?0- eii’thieoeaaeueiee ?iaeaen noaeeiieo ci?i EA - eaaaiaaee aioeaai EIE -eeiii?ioa?ae ethaeeie EO - eaeeio???i IAeA - iaeiiiaee ae?aeueaeaa?ae NE - iaoo?aeuei? e?ea?e II - ii?i?aei? iaioeaee IA - i?inoiaeaiaeeie IE - i?iaiinoe/iee eiao?oe??io IIE - ia?aeenia ieeneaiiy e?i?ae?a ?AIE - ?aaeoe?y aaeueioaaiiy i?a?aoe?? eaeeioeeo?a NIAe - noia?ieneaeaeeniooaca OA - oeioniee aioeaai Oo - o?iiaienai O? - oaaioeeoa?iee ?iaeaen O* - oaaioeeoa?ia /enei O?E - oee?eoethth/? ?ioii? eiiieaene CD3- oioaeuei? 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