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OA?EIANUeEEE AeA?AEAAIEE IAAeE*IEE OIIAA?NEOAO

AeOAAIEI Ay/aneaa Aaeaioeiiae/

OAeE 615.451.35+616.379-008.64-089+617-002.3-084

I?IOIEAEOEEA OA EIEOAAIIss ?AIIAI? IIOAEOeI? I?E OeOE?IAIIO AeIAAAO? C
AEEI?ENOAIIssI “Ae?IENECIETH”

14.01.03 – Oi?o?aiy

Aaoi?aoa?ao aeena?oaoei? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

OA?EIA – 1999

Aeena?oaoei?th ? ?oeiien.

?iaioa aeeiiaia o Oa?eianueeiio iinoeoooi oaeineiiaeaiiy eiea?ia IIC
Oe?a?ie.

Iaoeiaee ea?iaiee:

aeieoi? iaaee/ieo iaoe, i?ioani?, Aaeeaioeueeee Ieeiea Ieeieaeiae/,

caa?aeoaa/ eaoaae?e oi?aei-aaaeii?iaeueii? o??o?a?? Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a, caneoaeaiee aeiy/ iaoee Oe?a?ie,
eao?aao aea?aeaaii? i?aii? Oe?a?ie.

Ioioeieii iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?,Aeaoeaiei Ai?en Iaea?iae/,

caa?aeoaa/ eaoaae?e o??o?a?? oa i?ieoieia?? Oa?e?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a, Caneoaeaiee aeiy/ iaoee Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani?, Oai?inoia ?aaai Aeieo?iae/,

caa?aeoaa/ eaoaae?e o??o?a?/ieo oai?ia Oa?e?anueeiai aea?aeaaiiai
oi?aa?neoaoo

I?iaiaeia onoaiiaa – ?inoeooo ee?i?/ii? oa aenia?eiaioaeueii? o??o?a??
AII Oe?a?ie (i. Ee?a).

Caoeno aeena?oaoei? aiaeaoaeaoueny “29” ea?oiy 1999 ?. i 13.30 a. ia
caniaeaiii niaoeiaeiciaaiii? a/aii? ?aaee Ae 64.600.01 i?e Oa?eianueeiio
aea?aeaaiiio iaaee/iiio oiiaa?neoaoi (310022, i. Oa?eia, i?iniaeo
Eaiiia, 4).

C aeena?oaoei?th iiaeia iciaeiieoenue o aiae?ioaoei Oa?eianueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ca aae?anith: 310022, i. Oa?eia,
i?iniaeo Eaiiia, 4.

Aaoi?aoa?ao ?icineaii “5” aa?aciy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee:

eaiaeeaeao iaaee/ieo iaoe, aeioeaio I.I. Oaiueei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

AEOOAEUeIINOUe OAIE

Iiia?aaeaeaiiy ?aiiai? iioaeoei? i?e oeoe?iaiaiio aeiaaaoi ? aaaeeeaith
oi?o?ai/iith i?iaeaiith, ai i?e oeueiio caoai?thaaiii /anoioa
aiieii-iae?ioe/ieo oneeaaeiaiue cia/ii aeua, aiiae a iioeo iicieiai/ieo
a?oiao (I.N. ?oiiia, 1989; ?.A. Eoe?oia, 1990; A.I. Aacaoia, A.I.
Eae?i?i, 1991; ?.?. Nooa??a, 1993, 1998; N.I.Oaeiiia, 1995; G. Vadala et
al.,1991; G.W.M. Teterro et al.,1992). A oiiaao iioaeoeieiiai caiaeaiiy
aiaeaoaathoueny i?ioeane aeaeiiiainaoeiy oeoe?iaiai ae?aaaoo,
i?ia?anoaaiiy iioieneeaoei?, iaoaaie?/ii, iioiii oa iie?ioee?eoeyoi?ii
ii?ooaiiy, /anoioa aeieea? naioe/iee noai (I.I. Eocii, A.I. Einoth/aiie,
1990; A.?. Aei?o???a, 1998;).

A inoaiii aeanyoe?i//y aeiaaeee ianiai? ia?aoeiiiaeueii?
aioeaiioeeioa?aii? aiieii-caiaeueieo caoai?thaaiue o oai?eo ia oeoe?iaee
ae?aaao ni?eyee naeaeoei? aioeaiioeeinoieeeo ooaiia aaeoa?ie c aieueo
ae?aciith iaoiaaiiinoth, i?eaeaaiith iie?iaieie nai?ioioaie iaoiaaiieo
aeanoeainoae, noai?aiith oiia aeey a?eaeiaiai ?inoo, aeieeiaiith
?iciiiaiioieo oieneei-aea?ai/ieo ?aaeoeie, ui iaoiiaeei nooo?ai
iaiaaeaiiy uiaei canoinoaaiiy aioeaiioeeia (A.O. Na?iei, 1995, 1997;
N.Ae. Oaiiaae, 1998; M. Rossini, 1992). Oiio ana aieueoa oaaaa
i?eaeiey?oueny iaoiaeai iinoeaaiai aaeaeaaoiiai e?eoaaiiy oa
i?ioieaeoeee aiieieo oneeaaeiaiue o oai?eo ia oeoe?iaee ae?aaao (A.A.
?ooiae?e, 1998; N.?. Iiaei?yoia, 1998; I.I. Oi?, 1998). Cai?iaaaeaeaiiy
aeoeaieo eieoaaeueii-i?ioieaeoe/ieo caoiaeia, cie?aia ?aaeeeaeueii?
oi?o?ai/ii? naiaoei? oa aeoeaiiai ae?aioaaiiy ina?aaeea caiaeueii?
aeano?oeoei?, i?noeaaa canoinoaaiiy i?aia?ao?a, yei iathoue
aaaaoiooieoeiiiaeueii iiaeeeainoi oa /eiyoue aaaaoini?yiiaaio aeith a
ia?o?e oac? ?aiiaiai i?ioeano, ana oea ni?ey? i?eaii/aiith ?aiiai?
iioaeoei? oa caiiaiaa? o?eaaeiio ia?aaiao aiieiiai i?ioeano (A.O.
Caeoeaa, 1993; I.I. Eaioei, 1996; A.N. Aaoo?a,1997; A. I. Aeaoeaiei
1995, 1998; O.?. Oai, 1998;). Aea aea?? ?aoe?iiaeueiiai e?eoaaeueiiai
caniao, ui caeaaeeoue a?ae yeino? o??o?a?/ii? ia?iaee, oa?aeoa?o
caoaeiee?a ai?eii? ?ioaeoe??, oace ?aiiaiai i?ioeano, ia?aa?ao
oeoe?iaiai ae?aaaoo oa ee?i?ei-ii?oieia?/ieo i?iya?a ae?aaaoe/ieo
aia?iiao?e, caeeoa?oueny iaiaaeaiei, oiio ui aein? iaia? ni?iiiaeiino?
aeyaeoe aeineiiaeee iai?yi o eiiieaeniiio e?eoaaii? oa iiia?aaeaeaii?
o??o?a?/ii? ?ioaeoe?? o oai?eo ia oeoe?iaee ae?aaao. Oae, i?iaeaia
iiooe?a iioeiaeueieo cania?a eiiieaenii? ei?aeoe?? ?aiiaiai i?ioeano i?e
oeoe?iaiio ae?aaao?, ye? a caaania/oaaee cia/ia iie?ioaiiy ?acoeueoao?a
e?eoaaiiy ai?eieo ?ai ? nei?i/aiiy oa?i?i?a ?o caai?iiy, caeeoa?oueny
iaaeinoaoiuei ?ica’ycaiith, ui iaoiiaeth? ?? aeooaeuei?noue.

?iaioa i?enay/aia ?ica’ycaiith ieoaiiy i?aeaeuaiiy yeino? e?eoaaiiy oa
iiia?aaeaeaiiy o??o?a?/ii? ?ioaeoe?? i?e oeoe?iaiio ae?aaao?.
Aeioeieueiinoue aeineiaeaeaiiy iaoiiaeaia iaiaoiaeiinoth iiaeaeueoi?
?ic?iaee aoaeoeaieo iaoiaeia aeoeaiiai eiiieaeniiai e?eoaaiiy oa
i?ioieaeoeee aiieii-caiaeueieo caoai?thaaiue i’yeeo oeaiei o oai?eo ia
oeoe?iaee ae?aaao ?c aeeth/aiiyi aei ?o neeaaeo i?noeaai?
iaaeeeaiaioicii? ei?aeoe?? ?aiiaiai i?ioeano. A?aenooi?noue e?oa?aoo?ieo
aeaieo i?i aeei?enoaiiy o oai?eo ia oeoe?iaee ae?aaao eiiaiiiaaiiai
aioeiie?iaiiai iiiiiai aa?icieth c aeiieneaeeiii “Aeiienecieue” i?e
e?eoaaii? o??o?a?/ii? ?ioaeoe?? iaoiiaeei aea?? oeueiai i?aia?aoo aeey
iaoeo aeine?aeaeaiue.

Ca’ycie ?iaioe c iaoeiaeie ieaiaie. Iaoeiaa ?iaioa aeeiiaia ia eaoaae?i
oi?aei-aaaeii?iaeueii? o??o?a?? caiaeii c iniiaiei ieaiii Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a i ? naiinoieiei
eeii?ei-aenia?eiaioaeueiei aeineiaeaeaiiyi ii aea/aiith aoaeoeaiino?
canoinoaaiiy “Ae?ienecieth” o i?ia?ai? eiiieaeniiai o??o?a?/iiai
e?eoaaiiy ai?eii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei i?e oeoe?iaiio
ae?aaao?.

IAOA I CAAeA*I AeINEIAeAEAIIss

Iaoith i?aoei ? iiaeaeuaiiy aoaeoeaiinoi iinoeaaiai eieoaaiiy i
i?ioieaeoeee aiieii-iae?ioe/ieo oneeaaeiaiue o oai?eo ia oeoe?iaee
ae?aaao, ui aeinyaa?oueny aeei?enoaiiyi eiiaiiiaaiiai iiiiiai aa?icieth
c aeiieneaeeiii “Aeiienecieue”, i?ecia/aiiai aeey canoinoaaiiy a ia?oie
oaci ?aiiaiai i?ioeano, a eiiieaeni aeoeaii? i?ioieaeoeee iaaii?iue ?ai
iiney oi?o?ai/iiai eieoaaiiy ?icieo aiieii-iae?ioe/ieo caoai?thaaiue
i’yeeo oeaiei o oai?eo ia oeoe?iaee aeiaaao.

I?e aeeiiaiii ?iaioe aoee aecia/aii ianooiii caaaeaiiy aeineiaeaeaiiy:

1. Aenia?eiaioaeueia aea/aiiy niaoeeoi/ii? aioeaaeoa?iaeueii? aeoeaiinoi
“Aeiienecieth” uiaei “iniiaieo” aeaeia caoaeieeia oi?o?ai/ii? iioaeoei?:

a) in vitro a caeaaeiinoi aiae neeaaeo aa?iciey;

a) in vivo i?e ?icieo aa?iaioao eieoaaiiy aiieieo ?ai.

2. Aea/eoe eieoaaeueio aoaeoeai?noue “Ae?ienecieth” o oai?eo ia
oeoe?iaee ae?aaao c iayaieie iciaeaie ae?aaaoe/ieo aia?iiao?e.

3. Aea/eoe iniaeeainoi aei? “Aeiienecieth” i?e eieoaaiii aiieieo ?ai i?e
oeoe?iaiio ae?aaao?.

4. ?ic?iaeoe ?aoeiiiaeueio iaoiaeeeo eiiieaeniiai aeoeaiiai o??o?a?/iiai
e?eoaaiiy oa iiia?aaeaeaiiy ?aiiai? iioaeoei? c aeei?enoaiiyi
“Ae?ienecieth” o oai?eo ia oeoe?iaee ae?aaao c aiieii-iae?ioe/ieie
caoai?thaaiiyie i’yeeo oeaiei.

5. Aea/eoe eeiii/io aoaeoeaiinoue aeei?enoaiiy “Aeiienecieth” aeey
eiiieaenii? i?io?eaeoeee o oai?eo ia oeoe?iaee ae?aaao iaaii?iue eoene
i?ney aiiooaoe?? e?ioe?aee c i?eaiaeo ?? aaia?aie.

6. Aea/eoe eeiii/io aoaeoeaiinoue aeei?enoaiiy “Aeiienecieth” o
ii?aeiaiii c aeoeaiei ae?aioaaiiyi ?aie iiney oi?o?a?/ii? ia?iaee
ina?aaeeo aiieii-iae?ioe/ii? aeano?oeoei? aeey e?eoaaiiy ?aiiai?
iioaeoei? o oai?eo ia oeoe?iaee ae?aaao c iaeii/aniei caeieniaiiyi
i?ioeaeiaaaoe/ieo caoiaeia oa eiiieaenii? ei?aeoei? ii?ooaiue a nenoaii
aiiainoaco.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAOIA

Aenia?eiaioaeueii aeiaaaeaia aeioeieueiinoue aeei?enoaiiy
“Aeiienecieth”, i?ecia/aiiai aeey canoinoaaiiy a ia?oie oaci ?aiiaiai
i?ioeano, c iaoith aoaeoeaiiai iiia?aaeaeaiiy oi?o?ai/ii? iioaeoei? i?e
eieoaaiii aiieieo caoai?thaaiue i’yeeo oeaiei.

Aia?oa cai?iiiiiaaiee aoaeoeaiee cania eieoaaiiy oa i?ioieaeoeee
?aiiai? iioaeoei? o oai?eo ia oeoe?iaee ae?aaao ? oa ?? oei?a iiney
oi?o?ai/iiai eieoaaiiy aiieii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei.
Aii neeaaea?oueny c aeoeaiiai ae?aioaaiiy ?aie i canoinoaaiiy
“Aeiienecieth” iaeii/anii c i?iaaaeaiiyi ?aoeiiiaeueieo
i?ioeaeiaaaoe/ieo caoiaeia i eiiieaenii? iaoiaaiaoe/ii iaa?oioiaaii?
oa?aii?, ni?yiiaaii? ia ei?aeoeith ii?ooaiue a nenoaii aiiainoaco. Oea
caaacia/o? iie?auaiiy ?acoeueoao?a e?eoaaiiy ai?eieo oa
i?e?iaii-caa?oaeiaieo i?neyiia?aoe?eieo ?ai oa cia/ii nei?i/o? oa?i?ie
?o caai?iiy.

Aeei?enoaiiy “Aeiienecieth” a eiiieaeni aeoeaiiai iiia?aaeaeaiiy
iineyiia?aoeieieo iaaii?iue o oai?eo c ??ciei ia?aa?aii aaaeeino?
oeoe?iaiai ae?aaaoo oa ee?i?/iei i?iyaii ae?aaaoe/ieo aia?iiao?e
aeicaiey? aeineoue oaeaeei eieaiaeoaaoe iie?iaiee oaeoi?, ioiiethth/e
oe?ieee niaeo? iioaii? aiieii? iioaeoei?, ni?aaey? i?ia?aneaiee aieea ia
ia?aaia ia?oi? oace ?aiiaiai i?ioeano, caaacia/o? noaaieicaoeith i
iaoneeaaeiaia caai?iiy ?ai, i?enei?th? eiiiainaoe?th oeoe?iaiai ae?aaaoo
oa e?ea?aeaoe?th neiae?iio ?ioieneeaoe??. Oeei aeinyaa?oueny
iiaeeeainoue iiney ?aaeeeaeueii? naiaoei? ina?aaeeo caiaeueii?
aeano?oeoei? aiaeiiaeoenue, a aaaaoueio aeiaaeeao, aiae caaaeueii?
aioeaiioeeioa?aii?.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAOIA

Aenia?eiaioaeueii-eeiii/ieie aeineiaeaeaiiyie aeiaaaeaia aoaeoeaiinoue
aeei?enoaiiy iiiiiai aa?icieth “Aeiienecieue” c iaoith iiaiioeiiii?
i?ioieaeoeee iaaii?iue iineyiia?aoeieieo ?ai o oai?eo ia oeoe?iaee
aeiaaao. Oeae i?aia?ao iiia?aaeaeo? aeaiiioaaiiy oa ?icaeoie iie?ioei?e
a aiiei?e /e iie?iaii-caa?oaeiai?e ?ai?, ui ni?ey? noaaieicaoei?
?aiiaiai i?ioeano i aeicaiey?, a aieueoinoi aeiaaeeia, caaa?oeoe
?aaeeeaeueio oi?o?ai/io ia?iaeo aiieieea ?aiiii caoeaaiiyi ?aie.

?ic?iaeaiee oa ai?iaaaeaeaiee a oi?o?ai/io i?aeoeeo aoaeoeaiee iaoiae
eiiieaenii? i?ioieaeoeee ?aiiai? iioaeoei? i?e oeoe?iaiio ae?aaao?, yeee
neeaaea?oueny c aaaaeaiiy a ?aio “Aeiienecieth” oa ?? aeoeaiiai
ae?aioaaiiy iiney oi?o?ai/ii? naiaoei? ina?aaeeo aiieii-iae?ioe/ii?
aeano?oeoei? oa iaeii/aniiai i?iaaaeaiiy ?aoeiiiaeueiiai
i?ioeaeiaaaoe/iiai eieoaaiiy i oa?aiaaoe/ii? ei?aeoei? aeyaeaieo
ii?ooaiue a nenoaii aiiainoaco. “Ae?ienecieue” cia/ii iie?ioo?
aoaeoeai?noue e?eoaaiiy ai?eieo ?ai, ye? iathoue aeeaieo ii?iaeieio /e
neeaaeio eiio?ao?aoe?th.

Cai?iaaaeaeaiiy oeueiai iaoiaeo o oai?eo c ??ciei noaiii aaaeeino?
ia?aa?ao oeoe?iaiai ae?aaaoo oa ??ciei oa?aeoa?ii ee?i?/iiai i?iyao
ae?aaaoe/ieo aia?iiao?e aeicaieeei cia/ii i?enei?eoe i/euaiiy i
iaaeeeaiaioicio “noa?eeicaoeith” iioieiaaieo oa iie?iaii-caa?oaeiaieo
?ai, ciaioeoe oa?iiie ?o cae?eooy, noai?eoe oiiae aeey iaoneeaaeiaiiai
caaithaaiiy, ui iie?ioeei ?acoeueoaoe e?eoaaiiy oa i?enei?eei oaiie
iaeoaeaiiy oai?eo.

?ic?iaeaiee iaoiae ai?iaaaeaeaiiee a i?aeoe/io ?iaioo oi?o?ai/ieo
aiaeaeieaiue oa?eoi??aeueiiai iaaee/iiai ia’?aeiaiiy Aeca?aeeinueeiai
?aeiio, 2-? i?nueei? e?ea?i? oa aa?iiciiiiai ainiioaeth iinoa Oa?eiaa.
Iaoa??aee aeena?oaoe?eii? ?iaioe aeei?enoiaothoueny a o/iaiaiio i?ioean?
eaoaae?e oi?aeiaaaeiiiiaeueii? oi?o?ai? Oa?e?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a i?e iaa/aiii iioa?iia i ia oeeeeao caaaeueiiai oa
oaiaoe/iiai oaeineiiaeaiiy eiea?ia.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a i?e io?eiaiii iaoeiaeo
?acoeueoaoia ? iniiaiei i iieyaa? a aiaeici aeooaeueiinoi oa nooiaiy
aeineiaeaeaiinoi aaeoci ia?aii? oaiaoeee, a ia?aiii iai?yio, ianyaia oa
iaoiaeia aeineiaeaeaiiy, a iinoaiiaoei iaoe oa oi?ioethaaiii caaaeaiue,
o iiaeai?i oa eieoaaiii oai?eo, a aiaeici oa ocaaaeueiaiii io?eiaieo
?acoeueoaoia aeineiaeaeaiiy, oi?ioethaaiii aeniiaeia i iieiaeaiue, ui
aeiinyoueny ia caoeno, a oaeiae o iiaeaioiaoei iaoeiaeo aeaieo aei
ioaeieaoei? oa iia?aeiieaii? ?o ia ieaioii oa eiioa?aioeiyo.

Ai?iaaoe?y i?aoe?. I?i iniiaii iieiaeaiiy oa ?acoeueoaoe ?iaioe
iiaiaeiieaii oa aeeeaaeaii:

1) ia iaoeiai-i?aeoe/iie eiioa?aioei? oi?o?aia Oe?a?ie
“Aiieii-naioe/aneea ineiaeiaiey a iaioeiaeiie oe?o?aee” (i. Oa?eia,
12-14 eaioiy 1995 ?.); 2) ia Ieaioii i?aaeiiiy iaoeiaiai oiaa?enoaa
oi?o?aia Oe?a?ie “Oi?o?ai/ii iaoiaee ei?aeoei? oeoe?iaiai aeiaaaoo oa
eiai oneeaaeiaiue” (i. Iaeana, 15-17 o?aaiy 1996 ?.); 3) ia
iaoeiai-i?aeoe/iie eiioa?aioei? oi?o?aia “Aeooaeueiua aii?inu iauae e
iaioeiaeiie oe?o?aee” (i. Oa?eia, 21 o?aaiy 1996 ?.); 4) ia caniaeaiii
iaeaniiai iaoeiaiai oiaa?enoaa oi?o?aia (i. Oa?eia, /a?aaiue 1996 ?.);
5) ia tha?eaei?e eiioa?aioe?? (i. Iineaa, o?aaaiue, 1998).

Ioaeeeaoe?? ?acoeueoao?a aeine?aeaeaiiy. Ianya ? no?oeoo?a i?aoe?. Ca
oaiith aeena?oaoei? iioaeieiaaii 6 ae?oeiaaieo i?aoeue. ?iaioa
aeeeaaeaia ia 149 noi?iieao ae?oeiaaiiai oaenoo ? neeaaea?oueny ic
anooio, iaeyaeo eioa?aoo?e, 2 ?icae?e?a aeanieo aeineiaeaeaiue,
caeeth/aiiy, aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoeie, ia?aeieo 267
eioa?aoo?ieo aeaea?ae, c yeeo 196 – aio/eciyiieo oa 71 – caei?aeiiia.
?iaioa iethno?iaaia 21 oaaeeoeath (ianyaii o 12 noi??iie) oa 21 ?enoieii
(ianyaii o 15 noi??iie).

CIINO ?IAIOE

OA?AEOA?ENOEEA IAOIAeIEIAI? AeINEIAeAEAIIss

Ee?i?/i? aeine?aeaeaiiy i?iaaaeai? ia aeinoaoi?e e?eueeino?
niinoa?aaeaiue ia?aeaeueii c a?oiith ii??aiyiiy. I?ae /an aeineiaeaeaiiy
oaie aeena?oaoeieii? ?iaioe aeei?enoaii caaaeueiii?eeiyoee iaoiae
nenoaiiiai no?oeoo?ii-ooieoeiiiaeueiiai aiaeico oa i?eoaiaii? iaaee/iei
aeineiaeaeaiiyi ee?i?ei-a?io?i?/i?, iioiieiai/ii, iie?iaiieiai/ii,
ainoieiai/ii, oeeoieiai/ii, a oaeiae ?aiaacia?ao?/i? oa oa?iia?ao?/i?
iaoiaee aeine?aeaeaiiy.

IAOA?IAEE OA CANIAE AeINEIAeAEAIIss

A ?iaioi aeeeaaeaii ?acoeueoaoe aenia?eiaioaeueiiai aeineiaeaeaiiy
aioeaaeoa??aeueii? aeoeaiinoi “Ae?ienecieth” uiaei “iniiaieo” caoaeieeia
oi?o?a?/ii? iioaeoei?, oa iaoa?iaee eiiieaeniiai ianoaaeaiiy 167 oai?eo
ia oeoe?iaee ae?aaao I oa II oeiia, yei eieoaaeeny c i?eaiaeo
aiieii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei o eeii?oei c 1993 ii 1998
?iee. Eeiii/ia aoaeoeaiinoue “Ae?ienecieth” aea/aia i?e canoinoaaii?
eiai o eiiieaeni aeoeaii? i?ioieaeoeee oa e?eoaaiiy ?aiiai? iioaeoei? o
?aiiueiio iineyiia?aoeieiiio ia?iiaei o iacaaieo aeua oai?eo.

Aioeaaeoa?iaeueii yeinoi “Ae?ienecieth” aea/aii:

1) a aeineiaeao in vitro iaoiaeaie aeeooci? i?aia?aoa a aaa? i
eieueeiniiai iaeieo ?inoo iie?iaieo oie;

2) a aeineiaeao in vivo ia 3 iiaeaeyo:

a) aiieii? ?aie (eieoaaiiy caeienithaaeinue iiae iia’yceith);

a) caoeoi? iaaeooi ?aie iiney ?aaeeeaeueiiai aeni/aiiy aiieieea (ia?aae
caa’ycoaaiiyi oaia ?aio caiiaithaaee iiiith aa?icieth);

a) iioieiaaii? ?aaii-?ico?iuaii? ?aie, ia?aeiia oi?o?ai/ia ia?iaea yei?
aiaeno?i/aia ia 48 aiaeei i caaa?oaia iaeeaaeaiiyi aeooiai oao (aei
iiiaioo oi?o?ai/ii? ia?iaee ?aio eieoaaee iiae iia’yceith).

Aeey i?iaaaeaiiy aenia?eiaioia aoee aeei?enoaii (a?aeiia?aeii
?aeiiaiaeaoeiyi AIIC) “noaiaea?oii” iiaeeaii na?aaeiaeua oa aoaeiiii
ooaie oano-eoeueoo? (AeINE ii. E. A. Oa?anaae/a): cieioenoee noaoieieie,
eeoeiaa oa neiueiaiieia iaee/ee, aoeueaa?iee i?ioae, aaeoa?i?ae
o?aaeeein, eeino?eaeiy ia?o?iiaain. Iiae /an aeeiiaiiy ?iaioe no?iai
aeio?eioaaeeny i?aaee, yei caaaeaee ia aa?iaii oa aiaa?iaii aeanoeainoi
oeeo iie?ii?aai?ciia.

Aenia?eiaioe in vivo i?iaaaeaii ia 60 e?ieyo ii?iaee “Oeioeea”. Oaa?eie
aoee ia?iaii ?iciiaeieaii ia iniiaio oa eiio?ieueio a?oie.
Aioeaaeoa?iaeueia aeoeaiinoue “Ae?ienecieth”, canoiniaaiiai a iniiaiie
a?oii, ii?iaithaaeanue c aei?th “Oeeiacieth”, yeee aoa canoiniaaiee o
eiio?ieueiie a?oii.

C iaoith aea/aiiy eeiii/ii? aoaeoeaiinoi aeei?enoaiiy “Ae?ienecieth” a
eiiieaeni aeoeaiiai iiia?aaeaeaiiy ?aiiai? iioaeoei? o oai?eo ia
oeoe?iaee ae?aaao iiney oi?o?a?/iiai eieoaaiiy ?icieo aiieii-iae?ioe/ieo
caoai?thaaiue i’yeeo oeaiei ianoaaeaii 167 iaoei?ioia aieii aiae 31 aei
84 ?ieia. Oai?i aoee ?iciiaeieaii ia aeai a?oie: iniiaio (84 iniae) i
ii?iaiyeueio (83 iniae). Aiieii-aeano?oeoeaii iicieiai/ii oi?ie
aiaeia?aaeaii a oaa.1. Aaaeea oi?ia ia?aaiao oeoe?iaiai aeiaaaoo I oeio
aecia/aia o 51 oai?iai. II oei oeoe?iaiai ae?aaaoo c ia?aaiaii
na?aaeiuei? aaaeeinoi aecia/aiee o 87 oai?eo, eaaei? – o 29. Oni oai?i
iaee aieueo /e iaio ae?aaeaio noiooith iaoieiaith, ui iaoyaeoaaea
ia?aaia ?aiiaiai i?ioeano.

A caeaaeiinoi aiae aaaeeinoi ia?aaiao oeoe?iaiai ae?aaaoo, iaiaaeaiinoi
i?ioeano caiaeueii? aeano?oeoei? i ianyao oi?o?ai/iiai eieoaaiiy oni
oai?i oaeiae aoee ?iciiaeieaii ia o?e eeiii/ii iiaea?oie. Eieoaaiiy
caeienithaaeiny ca i?eioeeiii aeoeaii? oi?o?ai/ii? oaeoeee. Ia?oo
eeiii/io

iiaea?oio neeaee 62 oai?eo c iaiaaeaieie aiieieeaie (?i i?iaaaeaii
?aaeeeaeueia aeni/aiiy aiieiiai naeaano?o c ia?aeiiei caoeaaiiyi ?aie).
Ae?oao – 54 oai?eo c iaiaiaaeaiei aiieiei i?ioeanii (?i aeeiioaaee
?aaeeeaeueiee ?icoei aiieieea, iaeneiaeueio iae?aeoiiith c ianooiiei
ia?aeiii-aiaeno?i/aiei /e ?aiiii aoi?eiiei cae?eooyi ?aie). 51 oai?iio
o?aouei? iiaea?oie c aaia?aiith eiioeiaee aeeiiaia aiiooaoeiy aeua ?iaiy
o?aaeaiiy. A onio aeiaaeeao ia?aae caoeaaiiyi ?aia ae?aioaaeanue ia
i?ioyci neeieiiiaith o?oaeith aeey i?iieaaiiy. A iniiaiie a?oii
o?aeoeieia ae?aioaaiiy (ic aeei?enoaiiyi oiciieia?/iiai ?ic/eio, yeee
iinoeoue 1% ia?aeeno aiaeith) ii?aeioaaeiny c aaaaeaiiyi 1-2 ?ace ia
aeiao a ii?iaeieio ?aie “Aeiienecieth”, yeee aeei?enoiaoaaee oaeiae ia
aoaii aeiooaiiai eieoaaiiy ?aie iiae iia’yceith. O oai?eo ii?iaiyeueii?
a?oie ?aie o?aeoeieii i?iieaaee aiaeiei ?ic/eiii oo?aoeeeiio (1:5000), a
o aeiaaeeao eieoaaiiy ?ai iiae iia’yceith aeei?enoiaoaaee “Oeeiacieue”.

Ia?aae ii/aoeii oi?o?ai/iiai eieoaaiiy onii oai?ei i?iaaaeaia aeinoaoiy
eiiiainaoeiy oeoe?iaiai ae?aaaoo ae?iaieie aeicaie i?inoiai iinoeiio,
a?aoiaoth/e iieacieee aeieaii/iiai oa aetheico?e/iiai i?ioieth,
ae?aciinoue i?iianieoei oa neiae?iio aiaeiaaiii? iioieneeaoei?.
Caaaeueia eieoaaeueia i?ia?aia iinoeea o?aaeeoeieii aeaciioieneeaoeieii
caoiaee, oa?aiaaoe/io ei?aeoeith aeyaeaieo ii?ooaiue o nenoaii
aiiainoaco oa noiooiio niiaoe/ieo caoai?thaaiue. Ii?yae c oeei
i?iaiaeeeany i?ioieaeoeea i?aaoeth oa, ca?aeii iieacaiiyi, aaciai?
iioaeoei? a?aeiia?aeii caaaeueiii?eeiyoei noaiai. Iiney iia?aoei? onii
oai?ei, iiae eiio?ieai ae?eaii/iiai oa aetheico?e/iiai i?ioieth,
i?ecia/aee naaeainiaaio aei?oo oa i?iaeiaaeoaaee aeei?enoiaoaaoe noaio
ei?aeoei? ?iaiy aeieaii? ae?iaieie aeicaie i?inoiai iinoeiio (E.I.
Ieoeii oa niiaaao., 1982; I.N. ?o?iia, 1989; A.I. Aacaoia, A.I. Eaeiiii,
1991). Oai?ei, iia?iaaiei c i?eaiaeo aaia?aie eiioeiaee oa iaiaiaaeaieo
aiieieeia, canoiniaoaaee o?aaeeoeieii caaaeueiiaeinooiii aioeaiioeee
iioe?aiiai niaeo?o aei?.

Iiae /an i?iaaaeaiiy aenia?eiaioaeueieo aeineiaeaeaiue in vivo oa i?e
ianoaaeaiii oai?eo ii?yae ic caaaeueiii?eeiyoeie eeiiiei-aiioiii/ieie
caniaaie aeei?enoaii niaoeiaeueii caniae aeineiaeaeaiiy oa caai?o
iaoa?iaeo. Ia?aaia ?aiiaiai i?ioeano eiio?iethaaee oeyoii ainoieiai/iiai
oa aaeoa?iieiai/iiai aea/aiiy ?aiiaeo noano?aoia. Aeey oeueiai, i?e
aeeiiaiii oi?o?ai/ii? ia?iaee oa a iineyiia?aoeieiiio ia?iiaei,
i?iaiaeeee aiiinith ?aie. I?e aaeoa?iieiai/iiio eiio?iei aiiioao, yeee
iinoea iie?ioei?o, caniaaee ia iiaeeaii na?aaeiaeua. Iioii aecia/aee
eieueeinoue iie?ii?aaieciia a iaeiiio a?aii oeaieie. Aiaa?iaio
iie?ioei?o, ui ia aecia/a?oueny cae/aeieie caniaaie, aeyaeyee
aiaeiiaiaeii iaoiaee/iei ?aeiiaiaeaoeiyi OIAeIII ii. I. I. Ia/ieeiaa
(1985 ?.). Iie?iaio /ooeeainoue aei aioeaiioeeia aecia/aee ca
aeiiiiiaith noaiaea?oieo aeeneia, i?iaeeaeaieo i?aia?aoii. Oeeoieiai/iee
eiio?ieue aeeiaiiee caaithaaiiy caeienithaaee aea/aiiyi
iaceia-aiaeaeoeia ?ai ca caaaeueiii?eeiyoei iaoiaeii I.I. Iie?ianueei? i
I.N. Iaea?iaa. Oaeaeeinoue caaithaaiiy ?ai ia’?eoeaii ioeiithaaee ye
nei?i/aiiy ieiui ?aiiai? iiaa?oii. Aeii?thaaiiy ieiui ?aie i?iaiaeeee ca
aiaeiiei iaoiaeii E.I.Iiiiai? iaeei ?ac ia 4-5 aeia.

Ia?aei/aii niiniae eiio?ieth aeeiaiiee ?aiiaiai i?ioeano
aeiiiaithaaeeny ?aiaacia?aoi/iei (I.I. Ineieeiaa oa iio., 1980; C.E.
Caaaaaeuenueea oa iio., 1986) oa oa?iia?aoi/iei (A.I. Iaeueiieiaa, 1977)
aeineiaeaeaiiyie. A ia?oiio aeiaaeeo aeei?enoiaoaaee ?aia?ao ?4-02 oa
6-eaiaeueiee aeaeo?iea?aeiia?ao, a ae?oaiio -oaieiaici? “?aaeoaa”.

Oaeiae aecia/aee eaeeioeeoa?iee iiaeaen iioieneeaoei? ii Eaeue-Eaeioo,
aea/aee iioiieiai/ii oa?aeoa?enoeee e?iai oa ?? ?aieiai/ii aeanoeainoi c
aecia/aiiyi aaiinoaoe/iiai iioaioeiaeo oa oaeoi?ia ieacie i noaeeiii?
noiiee, yei aieeaathoue ia oiion i i?iieeiinoue iie?inoaeei. Ii?yae c
oeei i?eaeieyee oaaao noa’?eoeaiei aiae/oooyi oai?eo, oaeei ye caaaeueia
naiiii/oooy, aiaoeo, nii, iayaiinoue aieueiaiai neiae?iio oa ?io?i.

Iaea?aeaii a oeeo?iaiio ae?ac? ?acoeueoaoe aeine?aeaeaiue ia?iaeai?
iaia?aiao?e/ieie iaoiaeaie “O?-eaaae?ao” ? ca aeiiiiiaith ia?iiai
e?eoa??th A?euee?iniia. Iaeii?aciai aeine?aeaeai? iieacieee ia?iaeai? ca
iaoiaeii ii??aiyiiy na?aaei?o aaee/ei. Noaoenoe/ia ia?iaea ?acoeueoao?a
i?iaaaeaieo aeine?aeaeaiue aeeiiaia ia IAII oeio IBM PC ia i?ia?aiiiio
caaania/aii? o??ie “Mikrosoft” a iia?aoe?eieo na?aaeiaeuao Windows-95.
(I.A. Niaa?i, 1989; TH.?. Iiai?aethe, 1990).

?ACOEUeOAOE AeINEIAeAEAIIss

?acoeueoaoe aenia?eiaioo in vitro i?iaeaiiino?oaaee, ui aaeoa?ioeeaeia
aeoeaiinoue ?icieo neeaaeia aa?icieth c aeiieneaeeiii ? aenieith
i?e/aoii aei oano-eoeueoo? aoaeiieo ooaiia cieioenoiai noaoieieieo,
eeoeiai? oa neiueiai?eii? iaee/ie, aaeoa?iiaea o?aaeeein i eeino?eaei?
ia?o?iiaain.

Aeineiaeaie in vivo anoaiiaeaii, ui eeiii/ii iieacieee ia?aaiao
?aiiaiai i?ioeano (oa?iiie i/euaiiy ?ai i ii/aoeo noaaieueiiai ?icaeoeo
a?aioeyoeie i aiioaeicaoei? ?ai, na?aaeiy oaeaeeinoue caaithaaiiy ?ai)
i?e canoiniaoaaiii “Aeiienecieth” c aenieei nooiaiai ai?iaiaeiinoi
ia?aaa?oothoue aiaeiiaiaeii iieacieee o a?oiao eiio?ieth, aea aoa
canoiniaaiee “Oeeiacieue” (p0,05, o ii?iaiyiii c iieacieeaie caei?iaeo aeiii?ia). Aiaeiai/ii
ciiie i?inoaaeaii i na?aae iioio iieacieeia ianiaoeeoi/iiai caoenoo
i?aai?cio. Ia 5 aeiao aiaecia/aia /ioea oaiaeaioeiy iiaeaeuaiiy oeo?o
eicioeeio oa eiiieaiaioa?ii? aeoeaiinoi

ne?iaaoee e?iai. A caeeth/iiio ia??iae? niinoa?aaeaiue oaaioeeoa?ia
aeoeaiinoue inoioii ia?aaeuoaaea ii/aoeiai aeaii (p

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