3

OA?EIANUeEEE AeA?AEAAIEE IAAeE*IEE OIIAA?NEOAO

AeOAAIEI Ay/aneaa Aaeaioeiiae/

OAeE 615.451.35+616.379-008.64-089+617-002.3-084

I?IOIEAEOEEA OA EIEOAAIIss ?AIIAI? IIOAEOeI? I?E OeOE?IAIIO AeIAAAO? C
AEEI?ENOAIIssI “Ae?IENECIETH”

14.01.03 – Oi?o?aiy

Aaoi?aoa?ao aeena?oaoei? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

OA?EIA – 1999

Aeena?oaoei?th ? ?oeiien.

?iaioa aeeiiaia o Oa?eianueeiio iinoeoooi oaeineiiaeaiiy eiea?ia IIC
Oe?a?ie.

Iaoeiaee ea?iaiee:

aeieoi? iaaee/ieo iaoe, i?ioani?, Aaeeaioeueeee Ieeiea Ieeieaeiae/,

caa?aeoaa/ eaoaae?e oi?aei-aaaeii?iaeueii? o??o?a?? Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a, caneoaeaiee aeiy/ iaoee Oe?a?ie,
eao?aao aea?aeaaii? i?aii? Oe?a?ie.

Ioioeieii iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?,Aeaoeaiei Ai?en Iaea?iae/,

caa?aeoaa/ eaoaae?e o??o?a?? oa i?ieoieia?? Oa?e?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a, Caneoaeaiee aeiy/ iaoee Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani?, Oai?inoia ?aaai Aeieo?iae/,

caa?aeoaa/ eaoaae?e o??o?a?/ieo oai?ia Oa?e?anueeiai aea?aeaaiiai
oi?aa?neoaoo

I?iaiaeia onoaiiaa — ?inoeooo ee?i?/ii? oa aenia?eiaioaeueii? o??o?a??
AII Oe?a?ie (i. Ee?a).

Caoeno aeena?oaoei? aiaeaoaeaoueny «29» ea?oiy 1999 ?. i 13.30 a. ia
caniaeaiii niaoeiaeiciaaiii? a/aii? ?aaee Ae 64.600.01 i?e Oa?eianueeiio
aea?aeaaiiio iaaee/iiio oiiaa?neoaoi (310022, i. Oa?eia, i?iniaeo
Eaiiia, 4).

C aeena?oaoei?th iiaeia iciaeiieoenue o aiae?ioaoei Oa?eianueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ca aae?anith: 310022, i. Oa?eia,
i?iniaeo Eaiiia, 4.

Aaoi?aoa?ao ?icineaii «5» aa?aciy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee:

eaiaeeaeao iaaee/ieo iaoe, aeioeaio I.I. Oaiueei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

AEOOAEUeIINOUe OAIE

Iiia?aaeaeaiiy ?aiiai? iioaeoei? i?e oeoe?iaiaiio aeiaaaoi ? aaaeeeaith
oi?o?ai/iith i?iaeaiith, ai i?e oeueiio caoai?thaaiii /anoioa
aiieii-iae?ioe/ieo oneeaaeiaiue cia/ii aeua, aiiae a iioeo iicieiai/ieo
a?oiao (I.N. ?oiiia, 1989; ?.A. Eoe?oia, 1990; A.I. Aacaoia, A.I.
Eae?i?i, 1991; ?.?. Nooa??a, 1993, 1998; N.I.Oaeiiia, 1995; G. Vadala et
al.,1991; G.W.M. Teterro et al.,1992). A oiiaao iioaeoeieiiai caiaeaiiy
aiaeaoaathoueny i?ioeane aeaeiiiainaoeiy oeoe?iaiai ae?aaaoo,
i?ia?anoaaiiy iioieneeaoei?, iaoaaie?/ii, iioiii oa iie?ioee?eoeyoi?ii
ii?ooaiiy, /anoioa aeieea? naioe/iee noai (I.I. Eocii, A.I. Einoth/aiie,
1990; A.?. Aei?o???a, 1998;).

A inoaiii aeanyoe?i//y aeiaaeee ianiai? ia?aoeiiiaeueii?
aioeaiioeeioa?aii? aiieii-caiaeueieo caoai?thaaiue o oai?eo ia oeoe?iaee
ae?aaao ni?eyee naeaeoei? aioeaiioeeinoieeeo ooaiia aaeoa?ie c aieueo
ae?aciith iaoiaaiiinoth, i?eaeaaiith iie?iaieie nai?ioioaie iaoiaaiieo
aeanoeainoae, noai?aiith oiia aeey a?eaeiaiai ?inoo, aeieeiaiith
?iciiiaiioieo oieneei-aea?ai/ieo ?aaeoeie, ui iaoiiaeei nooo?ai
iaiaaeaiiy uiaei canoinoaaiiy aioeaiioeeia (A.O. Na?iei, 1995, 1997;
N.Ae. Oaiiaae, 1998; M. Rossini, 1992). Oiio ana aieueoa oaaaa
i?eaeiey?oueny iaoiaeai iinoeaaiai aaeaeaaoiiai e?eoaaiiy oa
i?ioieaeoeee aiieieo oneeaaeiaiue o oai?eo ia oeoe?iaee ae?aaao (A.A.
?ooiae?e, 1998; N.?. Iiaei?yoia, 1998; I.I. Oi?, 1998). Cai?iaaaeaeaiiy
aeoeaieo eieoaaeueii-i?ioieaeoe/ieo caoiaeia, cie?aia ?aaeeeaeueii?
oi?o?ai/ii? naiaoei? oa aeoeaiiai ae?aioaaiiy ina?aaeea caiaeueii?
aeano?oeoei?, i?noeaaa canoinoaaiiy i?aia?ao?a, yei iathoue
aaaaoiooieoeiiiaeueii iiaeeeainoi oa /eiyoue aaaaoini?yiiaaio aeith a
ia?o?e oac? ?aiiaiai i?ioeano, ana oea ni?ey? i?eaii/aiith ?aiiai?
iioaeoei? oa caiiaiaa? o?eaaeiio ia?aaiao aiieiiai i?ioeano (A.O.
Caeoeaa, 1993; I.I. Eaioei, 1996; A.N. Aaoo?a,1997; A. I. Aeaoeaiei
1995, 1998; O.?. Oai, 1998;). Aea aea?? ?aoe?iiaeueiiai e?eoaaeueiiai
caniao, ui caeaaeeoue a?ae yeino? o??o?a?/ii? ia?iaee, oa?aeoa?o
caoaeiee?a ai?eii? ?ioaeoe??, oace ?aiiaiai i?ioeano, ia?aa?ao
oeoe?iaiai ae?aaaoo oa ee?i?ei-ii?oieia?/ieo i?iya?a ae?aaaoe/ieo
aia?iiao?e, caeeoa?oueny iaiaaeaiei, oiio ui aein? iaia? ni?iiiaeiino?
aeyaeoe aeineiiaeee iai?yi o eiiieaeniiio e?eoaaii? oa iiia?aaeaeaii?
o??o?a?/ii? ?ioaeoe?? o oai?eo ia oeoe?iaee ae?aaao. Oae, i?iaeaia
iiooe?a iioeiaeueieo cania?a eiiieaenii? ei?aeoe?? ?aiiaiai i?ioeano i?e
oeoe?iaiio ae?aaao?, ye? a caaania/oaaee cia/ia iie?ioaiiy ?acoeueoao?a
e?eoaaiiy ai?eieo ?ai ? nei?i/aiiy oa?i?i?a ?o caai?iiy, caeeoa?oueny
iaaeinoaoiuei ?ica’ycaiith, ui iaoiiaeth? ?? aeooaeuei?noue.

?iaioa i?enay/aia ?ica’ycaiith ieoaiiy i?aeaeuaiiy yeino? e?eoaaiiy oa
iiia?aaeaeaiiy o??o?a?/ii? ?ioaeoe?? i?e oeoe?iaiio ae?aaao?.
Aeioeieueiinoue aeineiaeaeaiiy iaoiiaeaia iaiaoiaeiinoth iiaeaeueoi?
?ic?iaee aoaeoeaieo iaoiaeia aeoeaiiai eiiieaeniiai e?eoaaiiy oa
i?ioieaeoeee aiieii-caiaeueieo caoai?thaaiue i’yeeo oeaiei o oai?eo ia
oeoe?iaee ae?aaao ?c aeeth/aiiyi aei ?o neeaaeo i?noeaai?
iaaeeeaiaioicii? ei?aeoe?? ?aiiaiai i?ioeano. A?aenooi?noue e?oa?aoo?ieo
aeaieo i?i aeei?enoaiiy o oai?eo ia oeoe?iaee ae?aaao eiiaiiiaaiiai
aioeiie?iaiiai iiiiiai aa?icieth c aeiieneaeeiii “Aeiienecieue” i?e
e?eoaaii? o??o?a?/ii? ?ioaeoe?? iaoiiaeei aea?? oeueiai i?aia?aoo aeey
iaoeo aeine?aeaeaiue.

Ca’ycie ?iaioe c iaoeiaeie ieaiaie. Iaoeiaa ?iaioa aeeiiaia ia eaoaae?i
oi?aei-aaaeii?iaeueii? o??o?a?? caiaeii c iniiaiei ieaiii Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a i ? naiinoieiei
eeii?ei-aenia?eiaioaeueiei aeineiaeaeaiiyi ii aea/aiith aoaeoeaiino?
canoinoaaiiy “Ae?ienecieth” o i?ia?ai? eiiieaeniiai o??o?a?/iiai
e?eoaaiiy ai?eii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei i?e oeoe?iaiio
ae?aaao?.

IAOA I CAAeA*I AeINEIAeAEAIIss

Iaoith i?aoei ? iiaeaeuaiiy aoaeoeaiinoi iinoeaaiai eieoaaiiy i
i?ioieaeoeee aiieii-iae?ioe/ieo oneeaaeiaiue o oai?eo ia oeoe?iaee
ae?aaao, ui aeinyaa?oueny aeei?enoaiiyi eiiaiiiaaiiai iiiiiai aa?icieth
c aeiieneaeeiii “Aeiienecieue”, i?ecia/aiiai aeey canoinoaaiiy a ia?oie
oaci ?aiiaiai i?ioeano, a eiiieaeni aeoeaii? i?ioieaeoeee iaaii?iue ?ai
iiney oi?o?ai/iiai eieoaaiiy ?icieo aiieii-iae?ioe/ieo caoai?thaaiue
i’yeeo oeaiei o oai?eo ia oeoe?iaee aeiaaao.

I?e aeeiiaiii ?iaioe aoee aecia/aii ianooiii caaaeaiiy aeineiaeaeaiiy:

1. Aenia?eiaioaeueia aea/aiiy niaoeeoi/ii? aioeaaeoa?iaeueii? aeoeaiinoi
“Aeiienecieth” uiaei “iniiaieo” aeaeia caoaeieeia oi?o?ai/ii? iioaeoei?:

a) in vitro a caeaaeiinoi aiae neeaaeo aa?iciey;

a) in vivo i?e ?icieo aa?iaioao eieoaaiiy aiieieo ?ai.

2. Aea/eoe eieoaaeueio aoaeoeai?noue “Ae?ienecieth” o oai?eo ia
oeoe?iaee ae?aaao c iayaieie iciaeaie ae?aaaoe/ieo aia?iiao?e.

3. Aea/eoe iniaeeainoi aei? “Aeiienecieth” i?e eieoaaiii aiieieo ?ai i?e
oeoe?iaiio ae?aaao?.

4. ?ic?iaeoe ?aoeiiiaeueio iaoiaeeeo eiiieaeniiai aeoeaiiai o??o?a?/iiai
e?eoaaiiy oa iiia?aaeaeaiiy ?aiiai? iioaeoei? c aeei?enoaiiyi
“Ae?ienecieth” o oai?eo ia oeoe?iaee ae?aaao c aiieii-iae?ioe/ieie
caoai?thaaiiyie i’yeeo oeaiei.

5. Aea/eoe eeiii/io aoaeoeaiinoue aeei?enoaiiy “Aeiienecieth” aeey
eiiieaenii? i?io?eaeoeee o oai?eo ia oeoe?iaee ae?aaao iaaii?iue eoene
i?ney aiiooaoe?? e?ioe?aee c i?eaiaeo ?? aaia?aie.

6. Aea/eoe eeiii/io aoaeoeaiinoue aeei?enoaiiy “Aeiienecieth” o
ii?aeiaiii c aeoeaiei ae?aioaaiiyi ?aie iiney oi?o?a?/ii? ia?iaee
ina?aaeeo aiieii-iae?ioe/ii? aeano?oeoei? aeey e?eoaaiiy ?aiiai?
iioaeoei? o oai?eo ia oeoe?iaee ae?aaao c iaeii/aniei caeieniaiiyi
i?ioeaeiaaaoe/ieo caoiaeia oa eiiieaenii? ei?aeoei? ii?ooaiue a nenoaii
aiiainoaco.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAOIA

Aenia?eiaioaeueii aeiaaaeaia aeioeieueiinoue aeei?enoaiiy
“Aeiienecieth”, i?ecia/aiiai aeey canoinoaaiiy a ia?oie oaci ?aiiaiai
i?ioeano, c iaoith aoaeoeaiiai iiia?aaeaeaiiy oi?o?ai/ii? iioaeoei? i?e
eieoaaiii aiieieo caoai?thaaiue i’yeeo oeaiei.

Aia?oa cai?iiiiiaaiee aoaeoeaiee cania eieoaaiiy oa i?ioieaeoeee
?aiiai? iioaeoei? o oai?eo ia oeoe?iaee ae?aaao ? oa ?? oei?a iiney
oi?o?ai/iiai eieoaaiiy aiieii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei.
Aii neeaaea?oueny c aeoeaiiai ae?aioaaiiy ?aie i canoinoaaiiy
“Aeiienecieth” iaeii/anii c i?iaaaeaiiyi ?aoeiiiaeueieo
i?ioeaeiaaaoe/ieo caoiaeia i eiiieaenii? iaoiaaiaoe/ii iaa?oioiaaii?
oa?aii?, ni?yiiaaii? ia ei?aeoeith ii?ooaiue a nenoaii aiiainoaco. Oea
caaacia/o? iie?auaiiy ?acoeueoao?a e?eoaaiiy ai?eieo oa
i?e?iaii-caa?oaeiaieo i?neyiia?aoe?eieo ?ai oa cia/ii nei?i/o? oa?i?ie
?o caai?iiy.

Aeei?enoaiiy “Aeiienecieth” a eiiieaeni aeoeaiiai iiia?aaeaeaiiy
iineyiia?aoeieieo iaaii?iue o oai?eo c ??ciei ia?aa?aii aaaeeino?
oeoe?iaiai ae?aaaoo oa ee?i?/iei i?iyaii ae?aaaoe/ieo aia?iiao?e
aeicaiey? aeineoue oaeaeei eieaiaeoaaoe iie?iaiee oaeoi?, ioiiethth/e
oe?ieee niaeo? iioaii? aiieii? iioaeoei?, ni?aaey? i?ia?aneaiee aieea ia
ia?aaia ia?oi? oace ?aiiaiai i?ioeano, caaacia/o? noaaieicaoeith i
iaoneeaaeiaia caai?iiy ?ai, i?enei?th? eiiiainaoe?th oeoe?iaiai ae?aaaoo
oa e?ea?aeaoe?th neiae?iio ?ioieneeaoe??. Oeei aeinyaa?oueny
iiaeeeainoue iiney ?aaeeeaeueii? naiaoei? ina?aaeeo caiaeueii?
aeano?oeoei? aiaeiiaeoenue, a aaaaoueio aeiaaeeao, aiae caaaeueii?
aioeaiioeeioa?aii?.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAOIA

Aenia?eiaioaeueii-eeiii/ieie aeineiaeaeaiiyie aeiaaaeaia aoaeoeaiinoue
aeei?enoaiiy iiiiiai aa?icieth “Aeiienecieue” c iaoith iiaiioeiiii?
i?ioieaeoeee iaaii?iue iineyiia?aoeieieo ?ai o oai?eo ia oeoe?iaee
aeiaaao. Oeae i?aia?ao iiia?aaeaeo? aeaiiioaaiiy oa ?icaeoie iie?ioei?e
a aiiei?e /e iie?iaii-caa?oaeiai?e ?ai?, ui ni?ey? noaaieicaoei?
?aiiaiai i?ioeano i aeicaiey?, a aieueoinoi aeiaaeeia, caaa?oeoe
?aaeeeaeueio oi?o?ai/io ia?iaeo aiieieea ?aiiii caoeaaiiyi ?aie.

?ic?iaeaiee oa ai?iaaaeaeaiee a oi?o?ai/io i?aeoeeo aoaeoeaiee iaoiae
eiiieaenii? i?ioieaeoeee ?aiiai? iioaeoei? i?e oeoe?iaiio ae?aaao?, yeee
neeaaea?oueny c aaaaeaiiy a ?aio “Aeiienecieth” oa ?? aeoeaiiai
ae?aioaaiiy iiney oi?o?ai/ii? naiaoei? ina?aaeeo aiieii-iae?ioe/ii?
aeano?oeoei? oa iaeii/aniiai i?iaaaeaiiy ?aoeiiiaeueiiai
i?ioeaeiaaaoe/iiai eieoaaiiy i oa?aiaaoe/ii? ei?aeoei? aeyaeaieo
ii?ooaiue a nenoaii aiiainoaco. “Ae?ienecieue” cia/ii iie?ioo?
aoaeoeai?noue e?eoaaiiy ai?eieo ?ai, ye? iathoue aeeaieo ii?iaeieio /e
neeaaeio eiio?ao?aoe?th.

Cai?iaaaeaeaiiy oeueiai iaoiaeo o oai?eo c ??ciei noaiii aaaeeino?
ia?aa?ao oeoe?iaiai ae?aaaoo oa ??ciei oa?aeoa?ii ee?i?/iiai i?iyao
ae?aaaoe/ieo aia?iiao?e aeicaieeei cia/ii i?enei?eoe i/euaiiy i
iaaeeeaiaioicio “noa?eeicaoeith” iioieiaaieo oa iie?iaii-caa?oaeiaieo
?ai, ciaioeoe oa?iiie ?o cae?eooy, noai?eoe oiiae aeey iaoneeaaeiaiiai
caaithaaiiy, ui iie?ioeei ?acoeueoaoe e?eoaaiiy oa i?enei?eei oaiie
iaeoaeaiiy oai?eo.

?ic?iaeaiee iaoiae ai?iaaaeaeaiiee a i?aeoe/io ?iaioo oi?o?ai/ieo
aiaeaeieaiue oa?eoi??aeueiiai iaaee/iiai ia’?aeiaiiy Aeca?aeeinueeiai
?aeiio, 2-? i?nueei? e?ea?i? oa aa?iiciiiiai ainiioaeth iinoa Oa?eiaa.
Iaoa??aee aeena?oaoe?eii? ?iaioe aeei?enoiaothoueny a o/iaiaiio i?ioean?
eaoaae?e oi?aeiaaaeiiiiaeueii? oi?o?ai? Oa?e?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a i?e iaa/aiii iioa?iia i ia oeeeeao caaaeueiiai oa
oaiaoe/iiai oaeineiiaeaiiy eiea?ia.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a i?e io?eiaiii iaoeiaeo
?acoeueoaoia ? iniiaiei i iieyaa? a aiaeici aeooaeueiinoi oa nooiaiy
aeineiaeaeaiinoi aaeoci ia?aii? oaiaoeee, a ia?aiii iai?yio, ianyaia oa
iaoiaeia aeineiaeaeaiiy, a iinoaiiaoei iaoe oa oi?ioethaaiii caaaeaiue,
o iiaeai?i oa eieoaaiii oai?eo, a aiaeici oa ocaaaeueiaiii io?eiaieo
?acoeueoaoia aeineiaeaeaiiy, oi?ioethaaiii aeniiaeia i iieiaeaiue, ui
aeiinyoueny ia caoeno, a oaeiae o iiaeaioiaoei iaoeiaeo aeaieo aei
ioaeieaoei? oa iia?aeiieaii? ?o ia ieaioii oa eiioa?aioeiyo.

Ai?iaaoe?y i?aoe?. I?i iniiaii iieiaeaiiy oa ?acoeueoaoe ?iaioe
iiaiaeiieaii oa aeeeaaeaii:

1) ia iaoeiai-i?aeoe/iie eiioa?aioei? oi?o?aia Oe?a?ie
“Aiieii-naioe/aneea ineiaeiaiey a iaioeiaeiie oe?o?aee” (i. Oa?eia,
12-14 eaioiy 1995 ?.); 2) ia Ieaioii i?aaeiiiy iaoeiaiai oiaa?enoaa
oi?o?aia Oe?a?ie “Oi?o?ai/ii iaoiaee ei?aeoei? oeoe?iaiai aeiaaaoo oa
eiai oneeaaeiaiue” (i. Iaeana, 15-17 o?aaiy 1996 ?.); 3) ia
iaoeiai-i?aeoe/iie eiioa?aioei? oi?o?aia “Aeooaeueiua aii?inu iauae e
iaioeiaeiie oe?o?aee” (i. Oa?eia, 21 o?aaiy 1996 ?.); 4) ia caniaeaiii
iaeaniiai iaoeiaiai oiaa?enoaa oi?o?aia (i. Oa?eia, /a?aaiue 1996 ?.);
5) ia tha?eaei?e eiioa?aioe?? (i. Iineaa, o?aaaiue, 1998).

Ioaeeeaoe?? ?acoeueoao?a aeine?aeaeaiiy. Ianya ? no?oeoo?a i?aoe?. Ca
oaiith aeena?oaoei? iioaeieiaaii 6 ae?oeiaaieo i?aoeue. ?iaioa
aeeeaaeaia ia 149 noi?iieao ae?oeiaaiiai oaenoo ? neeaaea?oueny ic
anooio, iaeyaeo eioa?aoo?e, 2 ?icae?e?a aeanieo aeineiaeaeaiue,
caeeth/aiiy, aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoeie, ia?aeieo 267
eioa?aoo?ieo aeaea?ae, c yeeo 196 — aio/eciyiieo oa 71 — caei?aeiiia.
?iaioa iethno?iaaia 21 oaaeeoeath (ianyaii o 12 noi??iie) oa 21 ?enoieii
(ianyaii o 15 noi??iie).

CIINO ?IAIOE

OA?AEOA?ENOEEA IAOIAeIEIAI? AeINEIAeAEAIIss

Ee?i?/i? aeine?aeaeaiiy i?iaaaeai? ia aeinoaoi?e e?eueeino?
niinoa?aaeaiue ia?aeaeueii c a?oiith ii??aiyiiy. I?ae /an aeineiaeaeaiiy
oaie aeena?oaoeieii? ?iaioe aeei?enoaii caaaeueiii?eeiyoee iaoiae
nenoaiiiai no?oeoo?ii-ooieoeiiiaeueiiai aiaeico oa i?eoaiaii? iaaee/iei
aeineiaeaeaiiyi ee?i?ei-a?io?i?/i?, iioiieiai/ii, iie?iaiieiai/ii,
ainoieiai/ii, oeeoieiai/ii, a oaeiae ?aiaacia?ao?/i? oa oa?iia?ao?/i?
iaoiaee aeine?aeaeaiiy.

IAOA?IAEE OA CANIAE AeINEIAeAEAIIss

A ?iaioi aeeeaaeaii ?acoeueoaoe aenia?eiaioaeueiiai aeineiaeaeaiiy
aioeaaeoa??aeueii? aeoeaiinoi “Ae?ienecieth” uiaei “iniiaieo” caoaeieeia
oi?o?a?/ii? iioaeoei?, oa iaoa?iaee eiiieaeniiai ianoaaeaiiy 167 oai?eo
ia oeoe?iaee ae?aaao I oa II oeiia, yei eieoaaeeny c i?eaiaeo
aiieii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei o eeii?oei c 1993 ii 1998
?iee. Eeiii/ia aoaeoeaiinoue “Ae?ienecieth” aea/aia i?e canoinoaaii?
eiai o eiiieaeni aeoeaii? i?ioieaeoeee oa e?eoaaiiy ?aiiai? iioaeoei? o
?aiiueiio iineyiia?aoeieiiio ia?iiaei o iacaaieo aeua oai?eo.

Aioeaaeoa?iaeueii yeinoi “Ae?ienecieth” aea/aii:

1) a aeineiaeao in vitro iaoiaeaie aeeooci? i?aia?aoa a aaa? i
eieueeiniiai iaeieo ?inoo iie?iaieo oie;

2) a aeineiaeao in vivo ia 3 iiaeaeyo:

a) aiieii? ?aie (eieoaaiiy caeienithaaeinue iiae iia’yceith);

a) caoeoi? iaaeooi ?aie iiney ?aaeeeaeueiiai aeni/aiiy aiieieea (ia?aae
caa’ycoaaiiyi oaia ?aio caiiaithaaee iiiith aa?icieth);

a) iioieiaaii? ?aaii-?ico?iuaii? ?aie, ia?aeiia oi?o?ai/ia ia?iaea yei?
aiaeno?i/aia ia 48 aiaeei i caaa?oaia iaeeaaeaiiyi aeooiai oao (aei
iiiaioo oi?o?ai/ii? ia?iaee ?aio eieoaaee iiae iia’yceith).

Aeey i?iaaaeaiiy aenia?eiaioia aoee aeei?enoaii (a?aeiia?aeii
?aeiiaiaeaoeiyi AIIC) “noaiaea?oii” iiaeeaii na?aaeiaeua oa aoaeiiii
ooaie oano-eoeueoo? (AeINE ii. E. A. Oa?anaae/a): cieioenoee noaoieieie,
eeoeiaa oa neiueiaiieia iaee/ee, aoeueaa?iee i?ioae, aaeoa?i?ae
o?aaeeein, eeino?eaeiy ia?o?iiaain. Iiae /an aeeiiaiiy ?iaioe no?iai
aeio?eioaaeeny i?aaee, yei caaaeaee ia aa?iaii oa aiaa?iaii aeanoeainoi
oeeo iie?ii?aai?ciia.

Aenia?eiaioe in vivo i?iaaaeaii ia 60 e?ieyo ii?iaee “Oeioeea”. Oaa?eie
aoee ia?iaii ?iciiaeieaii ia iniiaio oa eiio?ieueio a?oie.
Aioeaaeoa?iaeueia aeoeaiinoue “Ae?ienecieth”, canoiniaaiiai a iniiaiie
a?oii, ii?iaithaaeanue c aei?th “Oeeiacieth”, yeee aoa canoiniaaiee o
eiio?ieueiie a?oii.

C iaoith aea/aiiy eeiii/ii? aoaeoeaiinoi aeei?enoaiiy “Ae?ienecieth” a
eiiieaeni aeoeaiiai iiia?aaeaeaiiy ?aiiai? iioaeoei? o oai?eo ia
oeoe?iaee ae?aaao iiney oi?o?a?/iiai eieoaaiiy ?icieo aiieii-iae?ioe/ieo
caoai?thaaiue i’yeeo oeaiei ianoaaeaii 167 iaoei?ioia aieii aiae 31 aei
84 ?ieia. Oai?i aoee ?iciiaeieaii ia aeai a?oie: iniiaio (84 iniae) i
ii?iaiyeueio (83 iniae). Aiieii-aeano?oeoeaii iicieiai/ii oi?ie
aiaeia?aaeaii a oaa.1. Aaaeea oi?ia ia?aaiao oeoe?iaiai aeiaaaoo I oeio
aecia/aia o 51 oai?iai. II oei oeoe?iaiai ae?aaaoo c ia?aaiaii
na?aaeiuei? aaaeeinoi aecia/aiee o 87 oai?eo, eaaei? — o 29. Oni oai?i
iaee aieueo /e iaio ae?aaeaio noiooith iaoieiaith, ui iaoyaeoaaea
ia?aaia ?aiiaiai i?ioeano.

A caeaaeiinoi aiae aaaeeinoi ia?aaiao oeoe?iaiai ae?aaaoo, iaiaaeaiinoi
i?ioeano caiaeueii? aeano?oeoei? i ianyao oi?o?ai/iiai eieoaaiiy oni
oai?i oaeiae aoee ?iciiaeieaii ia o?e eeiii/ii iiaea?oie. Eieoaaiiy
caeienithaaeiny ca i?eioeeiii aeoeaii? oi?o?ai/ii? oaeoeee. Ia?oo
eeiii/io

iiaea?oio neeaee 62 oai?eo c iaiaaeaieie aiieieeaie (?i i?iaaaeaii
?aaeeeaeueia aeni/aiiy aiieiiai naeaano?o c ia?aeiiei caoeaaiiyi ?aie).
Ae?oao — 54 oai?eo c iaiaiaaeaiei aiieiei i?ioeanii (?i aeeiioaaee
?aaeeeaeueiee ?icoei aiieieea, iaeneiaeueio iae?aeoiiith c ianooiiei
ia?aeiii-aiaeno?i/aiei /e ?aiiii aoi?eiiei cae?eooyi ?aie). 51 oai?iio
o?aouei? iiaea?oie c aaia?aiith eiioeiaee aeeiiaia aiiooaoeiy aeua ?iaiy
o?aaeaiiy. A onio aeiaaeeao ia?aae caoeaaiiyi ?aia ae?aioaaeanue ia
i?ioyci neeieiiiaith o?oaeith aeey i?iieaaiiy. A iniiaiie a?oii
o?aeoeieia ae?aioaaiiy (ic aeei?enoaiiyi oiciieia?/iiai ?ic/eio, yeee
iinoeoue 1% ia?aeeno aiaeith) ii?aeioaaeiny c aaaaeaiiyi 1-2 ?ace ia
aeiao a ii?iaeieio ?aie “Aeiienecieth”, yeee aeei?enoiaoaaee oaeiae ia
aoaii aeiooaiiai eieoaaiiy ?aie iiae iia’yceith. O oai?eo ii?iaiyeueii?
a?oie ?aie o?aeoeieii i?iieaaee aiaeiei ?ic/eiii oo?aoeeeiio (1:5000), a
o aeiaaeeao eieoaaiiy ?ai iiae iia’yceith aeei?enoiaoaaee “Oeeiacieue”.

Ia?aae ii/aoeii oi?o?ai/iiai eieoaaiiy onii oai?ei i?iaaaeaia aeinoaoiy
eiiiainaoeiy oeoe?iaiai ae?aaaoo ae?iaieie aeicaie i?inoiai iinoeiio,
a?aoiaoth/e iieacieee aeieaii/iiai oa aetheico?e/iiai i?ioieth,
ae?aciinoue i?iianieoei oa neiae?iio aiaeiaaiii? iioieneeaoei?.
Caaaeueia eieoaaeueia i?ia?aia iinoeea o?aaeeoeieii aeaciioieneeaoeieii
caoiaee, oa?aiaaoe/io ei?aeoeith aeyaeaieo ii?ooaiue o nenoaii
aiiainoaco oa noiooiio niiaoe/ieo caoai?thaaiue. Ii?yae c oeei
i?iaiaeeeany i?ioieaeoeea i?aaoeth oa, ca?aeii iieacaiiyi, aaciai?
iioaeoei? a?aeiia?aeii caaaeueiii?eeiyoei noaiai. Iiney iia?aoei? onii
oai?ei, iiae eiio?ieai ae?eaii/iiai oa aetheico?e/iiai i?ioieth,
i?ecia/aee naaeainiaaio aei?oo oa i?iaeiaaeoaaee aeei?enoiaoaaoe noaio
ei?aeoei? ?iaiy aeieaii? ae?iaieie aeicaie i?inoiai iinoeiio (E.I.
Ieoeii oa niiaaao., 1982; I.N. ?o?iia, 1989; A.I. Aacaoia, A.I. Eaeiiii,
1991). Oai?ei, iia?iaaiei c i?eaiaeo aaia?aie eiioeiaee oa iaiaiaaeaieo
aiieieeia, canoiniaoaaee o?aaeeoeieii caaaeueiiaeinooiii aioeaiioeee
iioe?aiiai niaeo?o aei?.

Iiae /an i?iaaaeaiiy aenia?eiaioaeueieo aeineiaeaeaiue in vivo oa i?e
ianoaaeaiii oai?eo ii?yae ic caaaeueiii?eeiyoeie eeiiiei-aiioiii/ieie
caniaaie aeei?enoaii niaoeiaeueii caniae aeineiaeaeaiiy oa caai?o
iaoa?iaeo. Ia?aaia ?aiiaiai i?ioeano eiio?iethaaee oeyoii ainoieiai/iiai
oa aaeoa?iieiai/iiai aea/aiiy ?aiiaeo noano?aoia. Aeey oeueiai, i?e
aeeiiaiii oi?o?ai/ii? ia?iaee oa a iineyiia?aoeieiiio ia?iiaei,
i?iaiaeeee aiiinith ?aie. I?e aaeoa?iieiai/iiio eiio?iei aiiioao, yeee
iinoea iie?ioei?o, caniaaee ia iiaeeaii na?aaeiaeua. Iioii aecia/aee
eieueeinoue iie?ii?aaieciia a iaeiiio a?aii oeaieie. Aiaa?iaio
iie?ioei?o, ui ia aecia/a?oueny cae/aeieie caniaaie, aeyaeyee
aiaeiiaiaeii iaoiaee/iei ?aeiiaiaeaoeiyi OIAeIII ii. I. I. Ia/ieeiaa
(1985 ?.). Iie?iaio /ooeeainoue aei aioeaiioeeia aecia/aee ca
aeiiiiiaith noaiaea?oieo aeeneia, i?iaeeaeaieo i?aia?aoii. Oeeoieiai/iee
eiio?ieue aeeiaiiee caaithaaiiy caeienithaaee aea/aiiyi
iaceia-aiaeaeoeia ?ai ca caaaeueiii?eeiyoei iaoiaeii I.I. Iie?ianueei? i
I.N. Iaea?iaa. Oaeaeeinoue caaithaaiiy ?ai ia’?eoeaii ioeiithaaee ye
nei?i/aiiy ieiui ?aiiai? iiaa?oii. Aeii?thaaiiy ieiui ?aie i?iaiaeeee ca
aiaeiiei iaoiaeii E.I.Iiiiai? iaeei ?ac ia 4-5 aeia.

Ia?aei/aii niiniae eiio?ieth aeeiaiiee ?aiiaiai i?ioeano
aeiiiaithaaeeny ?aiaacia?aoi/iei (I.I. Ineieeiaa oa iio., 1980; C.E.
Caaaaaeuenueea oa iio., 1986) oa oa?iia?aoi/iei (A.I. Iaeueiieiaa, 1977)
aeineiaeaeaiiyie. A ia?oiio aeiaaeeo aeei?enoiaoaaee ?aia?ao ?4-02 oa
6-eaiaeueiee aeaeo?iea?aeiia?ao, a ae?oaiio -oaieiaici? “?aaeoaa”.

Oaeiae aecia/aee eaeeioeeoa?iee iiaeaen iioieneeaoei? ii Eaeue-Eaeioo,
aea/aee iioiieiai/ii oa?aeoa?enoeee e?iai oa ?? ?aieiai/ii aeanoeainoi c
aecia/aiiyi aaiinoaoe/iiai iioaioeiaeo oa oaeoi?ia ieacie i noaeeiii?
noiiee, yei aieeaathoue ia oiion i i?iieeiinoue iie?inoaeei. Ii?yae c
oeei i?eaeieyee oaaao noa’?eoeaiei aiae/oooyi oai?eo, oaeei ye caaaeueia
naiiii/oooy, aiaoeo, nii, iayaiinoue aieueiaiai neiae?iio oa ?io?i.

Iaea?aeaii a oeeo?iaiio ae?ac? ?acoeueoaoe aeine?aeaeaiue ia?iaeai?
iaia?aiao?e/ieie iaoiaeaie “O?-eaaae?ao” ? ca aeiiiiiaith ia?iiai
e?eoa??th A?euee?iniia. Iaeii?aciai aeine?aeaeai? iieacieee ia?iaeai? ca
iaoiaeii ii??aiyiiy na?aaei?o aaee/ei. Noaoenoe/ia ia?iaea ?acoeueoao?a
i?iaaaeaieo aeine?aeaeaiue aeeiiaia ia IAII oeio IBM PC ia i?ia?aiiiio
caaania/aii? o??ie “Mikrosoft” a iia?aoe?eieo na?aaeiaeuao Windows-95.
(I.A. Niaa?i, 1989; TH.?. Iiai?aethe, 1990).

?ACOEUeOAOE AeINEIAeAEAIIss

?acoeueoaoe aenia?eiaioo in vitro i?iaeaiiino?oaaee, ui aaeoa?ioeeaeia
aeoeaiinoue ?icieo neeaaeia aa?icieth c aeiieneaeeiii ? aenieith
i?e/aoii aei oano-eoeueoo? aoaeiieo ooaiia cieioenoiai noaoieieieo,
eeoeiai? oa neiueiai?eii? iaee/ie, aaeoa?iiaea o?aaeeein i eeino?eaei?
ia?o?iiaain.

Aeineiaeaie in vivo anoaiiaeaii, ui eeiii/ii iieacieee ia?aaiao
?aiiaiai i?ioeano (oa?iiie i/euaiiy ?ai i ii/aoeo noaaieueiiai ?icaeoeo
a?aioeyoeie i aiioaeicaoei? ?ai, na?aaeiy oaeaeeinoue caaithaaiiy ?ai)
i?e canoiniaoaaiii “Aeiienecieth” c aenieei nooiaiai ai?iaiaeiinoi
ia?aaa?oothoue aiaeiiaiaeii iieacieee o a?oiao eiio?ieth, aea aoa
canoiniaaiee “Oeeiacieue” (p<0,05). Oae, ca aeaieie aenia?eiaioo ia iiaeaei aiieii? ?aie, ae?aciee eeiie/iee aoaeo a iniiaiie a?oii oaa?ei, ui naiae/ea i?i i?ia?aneaiee niaae ?iaiy iie?iaiiai canaaeaeaiiy ?ai oa ia?aoiae ia?oi? oace ?aiiaiai i?ioeano a ae?oao, ianoaaaa ia 4-5 aeia ?aiioa (p<0,05), iiae o oaa?ei a?oie eiio?ieth. Iieacieee oaeaeeinoi caaithaaiiy ?ai a iniiaiie a?oii ia?aaeuoaaee aiaeiai/ii o eiio?ieueiie: aiaeiiaiaeii 5,80,4% i 3,10,2% (p<0,05). Aieueo ae?aciee aioeaaeoa?iaeueiee aoaeo “Aeiienecieth” i?e eieoaaiii aiieii? ?aie a ia?oie oaci ?aiiaiai i?ioeanno aoa iiaeoaa?aeaeaiee i?e?iaiieiai/ieie aeineiaeaeaiiyie. Canoinoaaiiy “Aeiienecieth” ia iiaeaei caoeoi? iaaeooi ?aie iiney aeni/aiiy aanoeano i'yeeo oeaiei iiceoeaii aieeioei ia caai?iiy ?aie ii oeio ia?aeiiiai iaoyao, i?iaeaiiino?oaaei eeiii/io aoaeoeaiinoue eiai ye iaaeieiiai caniao i?ioieaeoeee ?aiiai? iioaeoei? a ?aiiueiio iineyiia?aoeieiiio ia?iiaei. Oea iiaeoaa?aeaeo?oueny ?acoeueoaoaie aaeoa?iieiai/iiai eiio?ieth a aeeiaiioei: ia 3 aeiao iiney iia?aoei? iie?iaia canaaeaeaiiy ?aie aoei nooo?ai ieae/a ii/aoeiaiai, ia ia?aaa?ooaaei “e?eoe/iiai” ?iaiy i ia 5 aeiao aenia?eiaioa iaei oaiaeaioeith aei i?ia?aneaiiai iaaeiiiy i cieeiaiiy (p<0,05). ?acoeueoaoe ainoieiai/iiai eiio?ieth oaeiae naiae/eee i?i iaoneeaaeiaiee ia?aaia ?aiiaiai i?ioeano o oaa?ei iniiaii? a?oie (p<0,05). Aeineiaeaie ia iiaeaei iioieiaaieo ?aaii-?ico?iuaieo ?ai aea/aia i iiaeoaa?aeaeaia ni?iiiaeiinoue “Aeiienecieth” noai?eoe aoaeo “eiina?aaoei?” iie?iaii-caa?oaeiaieo oa iioieiaaieo ?ai iiae /an aeiooaiiai aiaeno?i/aiiy ?o ia?aeiii? oi?o?ai/ii? ia?iaee ia 48 aiaeei. A onio oaa?ei iniiaii? a?oie iineyiia?aoeieii ?aie caai?eenue ii oeio ia?aeiiiai iaoyao, a ia?aaia ?aiiaiai i?ioeano aoa aeinoiai?ii noaaieueiei oa iaoneeaaeiaiiei, ui iiaeoaa?aeaeaii ?acoeueoaoaie ainoieiai/ieo aeineiaeia. Ia aiaeiiio aiae oeueiai, o a?oii eiio?ieth, a yeie aoa canoiniaaiee “Oeeiacieue”, o 4 c 10 aeiaaeeia (p<0,01) aeieeei iaaii?iiy ?ai. Oa?aeoa?o eeiii/iiai ia?aaiao ?aiiaiai i?ioeano a iniiaiie a?oii aiaeiiaiaeaa ?iaaiue iie?iaiiai canaaeaeaiiy ?ai. 24-aiaeeiia aeniiceoeiy “Aeiienecieth” a iioieiaaiie ?aii aeicaieeea cieceoe ?? aaeoa?iaeueia iaaaioaaeaiiy aei “e?eoe/iiai” ?iaiy. ? aaea /a?ac 48 aiaeeie, ia?aae aeeiiaiiyi ia?aeiii? oi?o?ai/ii? ia?iaee, oeae iieaciee neeaa 104 iie?iaieo oie a 1 a oeaieie i i?ia?aneaii cieaeoaaany ia i?ioyci iiaeaeueoiai aeiiai?/iiai iaaeyaeo: ia 3 aeiao ?iaaiue aaeoa?iaeueiiai canaaeaeaiiy ?ai neeaa 10?-10? iie?iaieo oie ia 1 a oeaieie, a ia 5 aeiao aaeoa?iieiai/ii caniae aoee a onio aeiaaeeao noa?eeueii (p<0,01). Ioaea, aiaeic iaea?aeaieo aeaieo iiaeoaa?aeaeo? iayaiinoue o “Aeiieneciey” o?eaaei? i noieei? caeaoiinoi i?eaii/oaaoe ?aiiao iie?ioei?o. Canoinoaaiiy oeueiai i?aia?aoo aeicaiey? caeiaooe iiaiioeiiiee i aeiaaino?ieiaee aoaeo iaaeeeaiaioicii? “eiina?aaoei?” iie?iaii-caa?oaeiaii? /e iioieiaaii? ?aie oa caaacia/eoe iaoneeaaeiaiee ia?aaia ?aiiaiai i?ioeano. Oaeei /eiii, ?acoeueoaoe aeeiiaieo aenia?eiaioia aeyaeee aenieo eeiii/io aoaeoeaiinoue “Aeiienecieth”, ye iaaeieiiai caniaa i?ioieaeoeee oa eieoaaiiy ?aiiai? iioaeoei?, ui iaaea? iiaeeeainoue oe?iei aeei?enoiaoaaoe oeae i?aia?ao a i?aeoe/iie oi?o?ai/iie aeiyeueiinoi. Iiae /an eeiii/ieo niinoa?aaeaiue aeey onio ianoaaeaieo oai?eo c iaio a?oi ii??aiyiiy aoee aeanoeai: aaeeea o?eaaeinoue caoai?thaaiiy (o na?aaeiueiio iiiaae 7 aeia ), iaiiaiioeiia eieoaaiiy aei ainiioaeicaoei? c iaaaeaeaaoiith aioeaaeoa?iaeueiith oa?aii?th, ia?aaaaeaiiy neiae?iio aiaeiaaiii? iioieneeaoei?, noeeueiinoue aei eaaieueiiai ia?aaiao oeoe?iaiai aeiaaaoo, iayaiinoue aeiaaaoe/ieo aiaiiiaoie oa ii?ooaiue i?ioeania iaoaaieicio. Eaa?eueiee ia?aa?a ?inoe?iiiacaeaaeiiai oeoe?iaiai ae?aaaoo cao?eniaaiee o 19 oai?eo c iaa?aeiaaeaieie ai?eieeaie i’yeeo oeaiei. O 51 oai?iai c aaia?aiith e?ioe?aie ?inoe?iicaeaaeiee oeoe?iaee ae?aaao ciaoiaeeany o oac? aeaeiiiainaoe??, ui aeyaeyeinue a?ia?ae?eai??th (a?ae 15,7 aei 26,4 iiieue/e), aetheico???th (a?ae 3 aei 5 %), eaoiio???th. ?icaeoie aaia?aie oa ?ioaeoe?eiee oieneeic a aeiiia?aoe?eiiio ia??iae? o 3 oai?eo i?ecaaee aei noaio ae?aaaoe/iiai eaoiaoeeaeico, o 2 oai?eo aeeeeeaee ?icaeiaiiy a?ia?ae?eai?/ii? oa o 3 - a?iiae?eai?/ii? eiie. Oaeiae caa?oaea ia naaa oaaao ?aciianthaeaeaiinoue caiaeueii-iae?ioe/iiai i?ioeano c iacaaaeaee /ioeith eeiii/iith ea?oeiith. O eeiii/iiio ia?aaiao ?aiiaiai i?ioeano iniiaieie aoee oaei iniaeeainoi, ye ieyaa caiaeueia ?aaeoeiy o aeiiia?aoeieiiio ia?iiaei, ae?ae iiaieueia i/euaiiy ?aie aiae aeao?ioo, caiiciaiiy iiyae a?aioeyoeie, yei aoee oueiyieie oa iiaiei caiiaithaaee ii?iaeieio ?aie, oaeiae iicii c'yaeyeenue iciaee aiioaeicaoei?. O 28,7% aeiaaeeao o oai?eo niinoa??aaeeny ee?i?/i? iciaee ae?naaeoa??ico oa eaiaeeaeico, ui aeieeee aiane?aeie aaceiio?ieueiiai aaeeaaiiy aioea?ioee?a. O 4,2% oai?eo a aiaiiac? aoee aeiaaeee ??ciiiai?oieo aea?a?/ieo ?aaeoe?e i?ney aaeeaaiiy aioea?ioee?a. ?acoeueoaoe eeiii/ieo niinoa?aaeaiue oeieeii iiaeoaa?aeaeaii ee?i?ei-a?io?i?/ieie, oeeoieiai/ieie oa ainoieiai/ieie aeineiaeaeaiiyie. Ii/aoeiai aaeoa?iieiai/ii aeineiaeaeaiy aeyaeee aeineoue aenieo aioeaiioeeinoieeinoue ?aiiai? iie?ioei?e, yea aoea ?ai?acaioiaaia ia?aaaaeii anioeiaoeiyie A?ai-iaaaoeaieo i A?ai-iiceoeaieo aaeoa?ie c aa?iaieie oa aiaa?iaieie aeanoeainoyie. ?iaaiue aaeoa?iaeueii? canaaeaeaiinoi a ciii aiieiiai naeaano?o cia/ii ia?aaeuoaaa “e?eoe/iee”, a ?aiiaa i?e?ioei?a iaea aeineoue aenieo aioea?ioeeino?ee?noue. O oai?eo aeyaeaii aeniei cia/aiiy eaeeioeeoa?iiai ?iaeaeno ?ioieneeaoe??, ?icii nooiaii aiii- i aeeni?ioaiiaii? oa ii?ooaiiy aaii?aieiai/ieo oa?aeoa?enoee (cia/ia caouaiiy i iiaeaeuaiiy aeaeeinoi e?iai, ae?aaeaia noeeueiinoue aei aiia?eiaaoeyoei?, iiaeaeuaiiy a ieacii eiioeaio?aoei? ?a/iaei, ui ii?ooothoue oiion oa i?iieeiinoue iie?inoaeei). Aeyaeaieie ii?oieiai/ieie iciaeaie aeiaaaoe/ii? aiaiiiaoi? aoee: iioiauaiiy eaiiey?ii? aacaeueii? iaia?aie, caoaeaiiy /e iaoo?aoeiy ioai?o oa?iiiaeueieo noaeei aiia?ieaciaaiei aiaeioaei?i, aioo?eoiueinoaeeiia neoi/aiiy iie?io?iiaia i i?iaeoeoia aeaa?aaeaoei? oia?iia, oia?iiiaaia oa a?eeiaeo eiaaoeyioia, aiaeeeaaeaiiy a noaeeiiie noiioei OEE-iiceoeaieo ?a/iaei, ia?eaaneoey?iee iaa?ye, cia/ia ciaioaiiy eieueeinoi ooieoeiiioth/eo eaiiey?ia, aeiaiaaeac o ia?eeaiiey?iee i?ino??. Cia/ia i?eaii/aiiy ia?eoa?ieiiai e?iaiiaiao a ciii aiieii-iae?ioe/ii? aeano?oeoei?, ui iiaeoaa?aeaeaia ?aiaacia?aoi/iei aeineiaeaeaiiyi, aoei iaoiiaeaia caieueoaiiyi ia?eoa?e/iiai iii?o, ii?ooaiiyi i?oaeiiaeanoe/ieo aeanoeainoae aaiicii? noiiee, cieaeaiiyi oa ao?a/aiiyi aeanoe/iino? a?oa?iaeueii? noiiee, ii?ooaiiyie eieaoa?aeueiiai e?iaiiaiao oa aaiiciiai aiaeieeao. Iiae /an oa?iia?aoi/ieo aeineiaeaeaiue o oai?eo c aaia?aiith ieaeiio eiioeiaie aeyaeyany oa?aeoa?iee neiioii “oa?ii/ii? aiiooaoei?”. Oa?iia?aoi/ia ea?oeia aiieieeia oa?aeoa?ecoaaeany e?oiiei ina?aaeeii iiaeaeuaiiai iio?a/a?aiiiai aei?iiiithaaiiy. Aenieiio oaiia?aoo?iiio a?aaei?ioiai (aei 2,80,3C) aiaeiiaiaeaei iiaeaeuaiiy oaiia?aoo?e oei?e iaae ciiith caiaeaiiy. Oni oai?i iaee aieueo /e iaio oa?aeoa?ii aeey ai?eii-caiaeueiiai i?ioeano ii?ooaiiy a iioiiiio noaii. Aecia/aii iiii?ia eieueeinia cieaeaiiy iiioeyoeie O- i A-eiioioeeoia oa noaiiioeyoei? aeoeaieo O-eiioioeeoia. Ii?ooaiiy aoii?aeueii? eaiee iioiioaoo noi?iaiaeaeoaaeiny cieaeaiiyi ?iaiae IgG, IgA i iiaeaeuaiii IgM. ?iaaiue oee?eoethth/eo iioiieo eiiieaenia aieueo, iiae aaeai/i ia?aaeuoaaa ii?io. I?eaii/aiiy nenoaie ianiaoeeoi/iiai caoenoo i?aai?cio oa?aeoa?ecoaaeiny iiieaeaiiyi oeo?ia eiiieaiaioo oa eicioeeio. Oaaioeeoa?ia aeoeai?noue e?iai aoea cieaeaia iaeaea aaeai/i aiae ii?ie (p<0,05). Aeeth/aiiy “Aeiienecieth” aei eiiieaeno eieoaaiiy ni?eyei cieaeaiith i?iyao oa o?eaaeinoi iioieneeaoei?, iiia?aaeaeaiith i?ia?anoaaiiy ?inoo ?aiiai? iie?ioei?e oa ?? cieuaiith, caaithaaiith iineyiia?aoeieieo ?ai aac aiieii-iae?ioe/ieo oneaaeiaiue. Aoaeo iinoeaai? aianoaci? aiaecia/aany i?aeoe/ii aaea /a?ac 15-20 oaeeei iiney aaaaeaiiy “Aeiienecieth” a ii?iaeieio ?aie i oo?eioaaany ia i?ioyci 5-12 aiaeei. Aeoeaia ae?aioaaiiy iie?iaii-caa?oaeiaieo oa iioieiaaieo ?ai ? canoinoaaiiy “Aeiienecieth” ni?eyee oaeaeeiio (ia 3-4 aeiao iiney iia?aoei?) cieeiaiith aieth i neiioiiia iinoeaaiai oa caaaeueiiai caiaeaiiy, iieiioaiith naiiii/oooy oai?eo ia 2-4 aeiae ?aiioa iiae o a?oii ii?iaiyiiy. Oaeiae aoee iiii/aii aieueo oaeaeei (ia i?ioyci 5-6 aeia) ?aa?an iaa?yeo oa iioieueo?aoei? i'yeeo oeaiei ia aeieyioei aiey oa?a oa aiioeia ?aie, i?enei?aiiy i?ioeania i/euaiiy ?aie, noaaieicaoeiy ?icaeoeo a?aioeyoeie i ii/aoie aiioaeicaoei?. A onio oai?eo iniiaii? a?oie caoeoi ?aie iiaiinoth caai?eeny ii oeio ia?aeiiiai iaoyao. Canoinoaaiiy “Aeiienecieth” o ii?aeiaiii c aeoeaiei ae?aioaaiiyi iineyiia?aoeieieo ?ai inoioii aieeaaei ia ?iaaiue ?o iie?iaiiai caa?oaeiaiiy. Oae, o 38,5% oai?eo ia?oi? eeiie/ii? iiaea?oie iiney oi?o?ai/ii? ia?iaee aiieieeia aoea aeyaeaia caa?oaeiaiinoue ?ai anioeiaoeiyie iioaii? iie?ioei?e. ?iaaiue aaeoa?iaeueiiai canaaeaeaiiy noiiie ?aiiaiai eaiaeo a 28,8% aeiaaee?a iniiaii? a?oie i o 36% ii?iaiyeueii? aoa ieae/a aiae “e?eoe/iiai” (3*104-5*10? iie?iaieo oie o 1 a oeaieie, p<0,05). Iiae aieeaii aeoeaiiai ae?aioaaiiy ? canoinoaaiiy “Aeiieneciey” aiaeaoany i?ia?aneaiee niaae iie?iaii? canaaeaeaiinoi, i ia 7 aeiao iiney iia?aoei? aaeoa?iieiae/ii caniae a onio aeiaaeeao aoee noa?eeueieie, aai i?e?ioei?a aen?aaeany o aeaeyae? ie?aieo eieii?e. Iai?ioe, o a?oii ii?iaiyiiy oa?iiie aeiiiiaoei? ?aiiai? iioaeoei? aeinoiai?ii aoee aieueo o?eaaeeie: a 22% aeiaaeeao ia 7 aeiao iiney oi?o?ai/ii? ia?iaee aaeoa?iieiai/ii caniae ua ?a?no?oaaee ?iaaiue caa?oaeiaiinoi a iaaeao 10?-10? iie?iaieo oie o 1 a (p<0,05), a a 14% aeiaaeeia o iaeaeeae/iio ia?iiaei iiney iia?aoei? noaeany aeoeaaoeiy iinoeaaiai caiaeueiiai i?ioeano, yeee aoa iaoiiaeaiee iiaeianaiiyi ?iaiy canaaeaeaiinoi ?ai aei “e?eoe/ieo” oeeo?. Oiio eieaiaeaoeiy iie?iaiiai oaeoi?o aiaeaoeany oieueee ia 15 aeiao iiney iia?aoei?. A ae?oa?e eeiii/iie iiaea?oii o oai?eo iaio a?oi ii?iaiyeueia aaeoa?iaeueia canaaeaeaiinoue noiiie ?aie iiney oi?o?a?/ii? ia?iaee neeaea a na?aaeiueiio (3,70,4) *104-(6,70,7)*106 iie?iaieo oie o 1 a oeaieie (p<0,05), ui iiaei aooe oaeoi?ii i?iaieaoe?? i iiaeaeueoiai ?icaeoeo aiieiiai caiaeaiiy a oiiaao oeoe?iaiai ae?aaaoo. Iiney iia?aoei? o oai?eo iniiaii? a?oie a onio aeiaaeeao aecia/aeiny noaaieueia cieaeaiiy ?iaiy ?aiiai? iie?ioei?e: aaea ia 3 aeiao aii ia ia?aaeuoaaa “e?eoe/iee”, ia 7 aeiao aoa cia/ii ieae/ei aiae iueiai (aei (6,40,5)*10?-(7,50,9) *10? iie?iaieo oie o 1 a (p<0,05)), a ia 9 - oni aaeoa?iieia?/ii caniae aoee noa?eeueieie. O a?oii ii?iaiyiiy aiaeia?/ia cieaeaiiy ?iaiy aaeoa?iaeueiiai canaaeaeaiiy oeaiei ?aie aoei caoieniaaia o 85,7% aeiaaee?a ia 12 aeiao, o iioeo 14,3%, c iaeiiiainiaaiith a?ia?ae?eai??th, aeieeei iaaii?iiy ?ai (aecia/aiee iie?iaiee eiiiiiaio – oeiiaa ainiioaeueia oei?a). O 7,8% oai?eo o?aouei? eeiii/ii? iiaea?oie a iaio a?oiao ii?iaiyiiy iiney aiiooaoei? o?aaeaii? aaia?aiith e?ioe?aee niinoa?iaaeenue iaeiaeiai ii/aoeiai ?iaii aaeoa?iaeueiiai caa?oaeiaiiy ?ai aei 10?-10? iie?iaieo oie ia 1 a oeaieie, oei /anii ye o ?aoo? aeiaaee?a aaeoa??ieia?/i? can?ae a?iioao?a ?ai aoee noa?eeuei?. Iaaeaei, o iaeaeeae/ee oa?iii iiney iia?aoei? (ia?oi o?e aeiae), a iniiaiie a?oii niinoa?iaaeanue iiaia eieaiaeaoeiy ?aiiaiai iie?iaiiai eiiiiiaioo, yea noi?iaiaeaeoaaeanue cieeiaiiyi ia??oieaeueiiai i?noeaaiai caiaeaiiy oa i?eieiaiiyi ai?eieo aeae?eaiue c ?aie. Ia oie /an o 9,8% oai?eo a?oie ii?iaiyiiy /a?ac i?ia?anoaaiiy ?aiiai? iioaeoei? ia 4-6 aeiao i?ney aiiooaoe?? aeieeei iaaii?iiy ?aie eoene, a oaeiae a?aeaoany eaa?eueiee ia?aa?a oeoe?iaiai ae?aaaoo c aeieeiaiiyi a 1 aeiaaeeo a?iiae?eai?/ii? eiie. Oaeei /eiii, canoinoaaiiy “Aeiienecieth” a eiiieaeni c aeoeaiei ae?aioaaiiyi iie?iaii-caa?oaeiaii? ?aie aeicaiey? iaaeieii iiia?aaeaeaoe ?icaeoie iinoeaaie aiieii? iioaeoei?, ui i?enei?th? eiiiainaoe?th oeoe?iaiai ae?aaaoo oa e?ea?aeaoe?th neiae?iio ?ioieneeaoe??. Oaeiae o?aaa cacia/eoe, ui ca aeaieie aioeaiioeeia?ai i?aeoe/ii a onio aeiaaeeao ia niinoa?iaaeiny eieeaaiue o c?inoaiii ?acinoaioiinoi aei aioeaaeoa?iaeueieo i?aia?aoia i?enooiuei? a aeineiaeaeaiiyo ?aiiai? iie?ioei?e. I?ae /an ee?i?/ieo niinoa?aaeaiue aoei aeyaeaii iiceoeaiee aieea ia ?acoeueoaoe oeeoieiai/ieo oa ii?oieiai/ieo aeineiaeaeaiue aeoeaiiai ae?aioaaiiy iie?iaii-caa?oaeiaieo iineyiia?aoeieieo ?ai o ii?aeiaiii c iinoeaaei canoinoaaiiyi “Aeiienecieth”. Oeeoia?aie iniiaii? a?oie o o?ueio eeiii/ieo iiaea?oiao aiaeaeee iiaeaeuaiiy oaiiia i/euaiiy ?aie, aeoeaiinoue i caaa?oaiinoue oaaioeeoico. Iiyaa a eeioeiieo neeaaeao oi?i, ui naiae/eee i?i ii/aoie i?ioeano ?aaaia?aoei?, niinoa?iaaeanue ia 4-6 aeia ?aiioa, iiae o a?oii ii?iaiyiiy i?e iaoneeaaeiai?i ia?aaic? caai?iiy. Aiaeiiaiaeii ciiie, iniaeeai o oai?eo c aaia?aiith e?ioe?aee, niinoa?iaaeeny oaeiae ? i?e ainoieiai/iiio aeineiaeaeaiii aiiioaoia ?ai. A iniiaiie a?oii ?aa?an caiaeueiiai iaa?yeo oa iioieueo?aoei? oeaiei, a oaeiae eieaiaeaoeiy cii iae?ico, c?inoaiiy a?aioeyoeie i oi?ioaaiiy oia?icii? oeaieie, ?aeiiiiceoeiy iie?ioee?eoeyoi?iiai ?onea c ?icaeoeii oe?iei? ia?aaei eaiiey?ieo aianoiiicia a?aeaoaaeeny ia 3-4 aeiae ?aiioa, iiae o a?oii ii?iaiyiiy. Ioaea, canoinoaaiiy “Aeiienecieth” o ii?aeiaiii c aeoeaiei ae?aioaaiiyi iineyiia?aoeieieo ?ai ni?eyei noaaieicaoei? ?aiiaiai i?ioeano, aeicaieeei oieeiooe aiieii-iae?ioe/ieo oneeaaeiaiue o ?aiiueiio iineyiia?aoeieiiio ia?iiaei oa onoiooe oaeoi?e, ui cao?eiothoue ia?aa?a caai?iiy. Aiaeic eeiiiei-aiioiii/ieo ?acoeueoaoia aeineiaeaeaiiy e?iai naiae/eoue, ui a iaio a?oiao ii?iaiyiiy ciiia ?iaith eaeeioeeoia oa onoiaiiy iciae aiiii?ioa?iai?? i aeeni?ioaiiaii? aoee noaoenoe/ii iaeiaeinoiai?ieie. Iiaeia aaaaeaoe aeinoiai?ieie i?enei?aio ii?iaeicaoeith niiaaiaeiioaiue eiiiiiaioia eaeeioeeoa?ii? oi?ioee, cieaeaiiy eaeeioeeoa?iiai ?iaeaeno ?ioieneeaoe?? i oaeaeeino? iniaeaiiy a?eo?ioeeoia, yei ?a?no?oaaeeny ia 2-4 aeiao aiae ii/aoeo oi?o?ai/iiai eieoaaiiy. Canoinoaaiiy “Aeiienecieth” a eiiieaeni aeoeaiiai ae?aioaaiiy iineyiia?aoeieieo ?ai iiceoeaii aieeioei ia noai eieaeueii? iie?ioee?eoeyoei?. Aeeiaiiea cieaeaiiy aaiinoaoe/iiai iioaioeiaeo e?iai oa ?? aeaeeinoi a iniiaiie a?oii iaei aiae?iciyeanue aiae aeeo/aieo aeaieo o a?oii ii?iaiyiiy, ai ani oai?i iaea?aeoaaee caaaeueio iaaeeeaiaioicio oa?aiith, ni?yiiaaio ia iie?ioaiiy aaii?aieiai/ieo oa?aeoa?enoee e?iai. Iaeiae, iie?auaiiy iieacieeia (oaae. 2), ui aiaeia?aaeathoue ooieoeiiiaeueiee noai iie?inoaeei, aiaeaoaaeiny a iniiaiie a?oii ia 3-4 aeiae ?aiioa, iiae o a?oii ii?iaiyiiy. Ia iie?auaiiy iie?ioee?eoeyoei? oaeiae aeacoaaee ?acoeueoaoe ?aiaacia?aoi/ieo i oa?iia?aoi/ieo aeineiaeaeaiue, ui naiae/eee i?i niaae ia?eoa?ieiiai iii?o, ooioiaiai a?oa?iiei-aaioey?iiai e?iaiiaiao oa iioeo iieacieeia oa?iiiaeueiiai e?iaiiaiao. O?aaa aiaecia/eoe, ui ia i?ioyci anueiai ia?iiaeo niinoa?aaeaiue iaeaieueo noieeeie aoee ii?ooaiiy aaiiciiai aiaeieeao o oai?eo, iia?iaaieo c i?eaiaeo aaia?aie e?ioe?aee. Aeoeaia ae?aioaaiiy iineyiia?aoeieieo ?ai ic canoinoaaiiyi “Aeiienecieth” ni?eyei noaaieicaoei? oa iaoneeaaeiaiiio ia?aaiao ia?oi? oace ?aiiaiai i?ioeano, i?i ui ai?iaiaeii na?ae/aoue iciaee aeoeaicaoei? oaeoi?ia ianiaoeeoi/ii? ?acenoaioiinoi, eeioeiiiai oa aoii?aeueiiai iioiioaoo (?en. 1, oaae. 3). Oae, inioth/a aei ii/aoeo eieoaaiiy a onio iaoei?ioia eiioioeeoiiaiiy aoea eieaiaeiaaia o oai?eo iniiaii? a?oie ia 3-4 aeiae ?aiioa. Iiaeaeuaiiy ooieoeiiiaeueii? aeoeaiinoi nenoaie A-e?ioioeeo?a o aeaeyaei ii?iaeicaoei? o ne?iaaooei e?iai eiioeaio?aoeie IgM, IgA, IgG niinoa??aaeiny c 5 aeiae iineyiia?aoeieiiai ia?iiaeo (p>0,05, o ii?iaiyiii c iieacieeaie caei?iaeo aeiii?ia). Aiaeiai/ii
ciiie i?inoaaeaii i na?aae iioio iieacieeia ianiaoeeoi/iiai caoenoo
i?aai?cio. Ia 5 aeiao aiaecia/aia /ioea oaiaeaioeiy iiaeaeuaiiy oeo?o
eicioeeio oa eiiieaiaioa?ii? aeoeaiinoi

ne?iaaoee e?iai. A caeeth/iiio ia??iae? niinoa?aaeaiue oaaioeeoa?ia
aeoeaiinoue inoioii ia?aaeuoaaea ii/aoeiai aeaii (p<0,05). Oaeei /eiii, ?aaeeeaeueia onoiaiiy ina?aaeeo caiaeueii-iae?ioe/ii? aeano?oeoei? i?e oeoe?iaiio ae?aaao? c iiaeaeueoei aeoeaiei ae?aioaaiiyi ?aie o ii?aeiaiii ?c canoinoaaiiyi “Aeiienecieth” aeicaiey? i?ia?aneaii aieeaaoe ia iie?iaiee oaeoi? oa iniiaii iaoaiicie iinoeaaiai aiieii-iae?ioe/iiai caiaeaiiy ia ii/aoeiaiio aoaii ?aiiaiai i?ioeano. Ona oea aeicaiey? i?enei?eoe iaeoaeoaaiiy oai?eo ? nei?ioeoe oa?i?i ?o ia?aaoaaiiy a noaoe?iia??. AENIIAEE 1. Aenia?eiaioaeueii oa eeiii/ii aeiaaaeaii, ui eiiaiiiaaiee iiiiee aa?icieue c aeiieneaeeiii “Aeiienecieue” ia? ae?acio aioeiie?iaio aeith uiaei “iniiaieo” caoaeieeia oi?o?a?/ii? iioaeoei?. 2. Aeoeaia ae?aioaaiiy ai?eii? ?aie ?c canoinoaaiiyi “Aeiienecieth” i?enei?th? ?? i/euaiiy a?ae iaaeeoo?caeaoieo oeaiei, ia?aoeiaeaea? aeaiiioaaiith iie?ioei?e, iiia?aaeaea? ?aiioieoaaiiy, aeicaiey? oaeaeei cieceoe ?iaaiue iie?iaii? canaaeaeaiinoi, ni?ey? aeoea?caoei? iaoai?ciia niaoeeoi/ii? oa ianiaoeeoi/ii? ?acenoaioiinoi, ui caaacia/o? aeinoaoith iaaeeeaiaioicio “noa?eeicaoeith” ?aie oa iaoneeaaeiaiee ia?aa?a ia?oi? oace ?aiiaiai i?ioeano. 3. I?ney ?aaeeeaeueii? oi?o?ai/ii? naiaoei? ina?aaeeo ai?eii-iae?ioe/ii? aeano?oeoei? o oai?eo ia oeoe?iaee ae?aaao I oa II oei?a aeoeaia ae?aioaaiiy ?aie c aaaaeaiiyi “Aeiienecieth” aaea ia ii/aoeiaeo aoaiao caai?iiy, a oiiaao aeinoaoiuei? eiiiainaoe?? ae?eai?? oa ei?aeoe?? aiiainoaoe/ieo ii?ooaiue, ? aaeaeaaoiei oa iaaeieiei caniaii i?ioieaeoeee ?aiiai? iioaeoei?. 4. Canoinoaaiiy eiiieaenii? i?ia?aie aeoeaiiai o??o?a?/iiai e?eoaaiiy ai?eii-iae?ioe/ieo caoai?thaaiue i’yeeo oeaiei o oai?eo c ??ciei noaiii aaaeeino? ia?aa?ao oeoe?iaiai ae?aaaoo I oa II oei?a oa c ee?i?ei-ii?oieia?/ieie iciaeaie iayaiino? ae?aaaoe/ieo aia?iiao?e ni?eyei eiiiainiaaiiio ia?aa?ao oeoe?iaiai ae?aaaoo, iiia?aaeaeaiith eiai oneeaaeiaiue oa i?enei?aiith e?ea?aeaoe?? ?ioieneeaoe??, ui iiceoeaii aieeioei ia i?ioeane caai?iiy oa i?enei?eei oaiie iaeoaeaiiy oai?eo. 5. I?ney aiiooaoe?? e?ioe?aee c i?eaiaeo ?? aaia?aie, ui aeieeea ia oiii aaaeeiai oa eaaieueiiai ia?aaiao oeoe?iaiai aeiaaaoo I oeio, aeoeaia ae?aioaaiiy eoene c aeei?enoaiiyi “Ae?ienecieth” a oiiaao aaeaeaaoiiai aioeae?aaaoe/iiai e?eoaaiiy oa ei?aeoe?? ii?ooaiue, ui aeieeee aiane?aeie i?ia?anoaaiiy aeeaaaoe/ii? aia?iiao?? oa iineeaiiy iaoaaie?/ieo ?iceaae?a, caaacia/o? iaoneeaaeiaia caai?iiy iineyiia?aoeieii? ?aie. 6. I?ney ?aaeeeaeueii? o??o?a?/ii? ia?iaee ai?eiee?a i’yeeo oeaiei o oai?eo ia oeoe?iaee aeiaaao II oeio aaaaeaiiy aei neeaaeo eiiieaenii? i?ia?aie o??o?a?/iiai e?eoaaiiy iaoiaeo aeoeaiiai ae?aioaaiiy cae?eoi? ?aie ?c ianooiiei caiiaiaiiyi ?? “Aeiienecieai” a ia?aaaaei?e a?eueoino? aeiaaee?a aeicaiey? iiia?aaeeoe oneeaaeiaiee ia?aa?a ?aiiaiai i?ioeano oa iiceoeaii aieeiooe ia caai?iiy ?aie ii oeio ia?aeiiiai iaoyao. I?AEOE*II ?AEIIAIAeAOeI? 1. Iaa?oioiaaii oe?iea aeei?enoaiiy a o??o?a?/i?e i?aeoeoe? “Aeiienecieth” ye i?aia?aoa aeai?o aeey oniioiiai eieoaaiiy oa i?ioieaeoeee ?aiiai? iioaeoei? o oai?eo ia oeoe?iaee aeiaaao I i II oeiia. 2. Iaia’yceiaeie oiiaaie iiia?aaeaeaiiy ?aiiai? ?ioaeoe?? oa i?neyiia?aoe?eieo oneeaaeiaiue o oai?eo ia oeoe?iaee aeiaaao I oa II oei?a, ye? iia?iaai? c i?eaiaeo aaia?aie e?ioe?aee oa ai?eiee?a i'yeeo oeaiei, ? caaaeueia aeac?ioieneeaoe?eia, aaeaeaaoia i?ioeae?aaaoe/ia oa eiiieaenia oa?ai?y iaoaaie?/ieo, i?e?ioee?eoeyoi?ieo oa ?ioiieo ii?ooaiue. 3. “Aeiienecieue” aeioe?eueii aaiaeeoe a ?aio ii ae?aiaaeo 1-2 ?ace ia aeiao i?ney iaeneiaeueiiai i/euaiiy ?? a?ae aeao?eoo oa aenoaeaoo. 4. Aeey iaea?aeaiiy iioeiaeueiiai aioeaaeoa??aeueiiai aoaeoo i?e i?noeaaiio e?eoaaii? oa i?io?eaeoeoe? ?aiiai? ?ioaeoe?? i?e oeoe?iaiio ae?aaao? iio??aii ii?aeioaaoe aeoeaia ae?aioaaiiy ?aie c aaaaeaiiyi a ?? ii?iaeieio “Aeiienecieth”. IA?AE?E I?AOeUe, IAAe?OEIAAIEO CA OAIITH AeENA?OAOeI? 1. I?ioeeaeoeea iaaiiaiey iia?aoeeiiiie ?aiu a aaaeiieiaeueiie oe?o?aee.// Eeiii/ia oi?o?aiy.-1995.- ?9-10, n. 20-21. (Ni?aaaoi?e: I.I. Aaeeaioeueeee, A.E. Oei??eyi). 2. Aeoeaiay i?ioeeaeoeea iineaiia?aoeeiiiiai iaaiiaiey o aieueiuo naoa?iui aeeaaaoii.// Eeiii/ia oi?o?aiy.-1996.- ?2-3, n. 63. (Ni?aaaoi?e: I.I. Aaeeaioeueeee, A.E. Oei??eyi, A.N. Aaoo?a, I.?. Na?iooaiia). 3. Eiiieaeniia ea/aiea eieaeueiuo aiieiuo caaieaaaiee iyaeeo oeaiae o aieueiuo naoa?iui aeeaaaoii.// Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.-1997.- ?3, n. 134-138. 4. Eiiieaeniay i?ioeeaeoeea aiieiie eioaeoeee ?ai a iineaiia?aoeeiiiii ia?eiaea o aieueiuo naoa?iui aeeaaaoii.// Eeiii/ia oi?o?aiy.-1998.- ?1.- N. 17-19. (Ni?aaaoi?e: I.I. Aaeeaioeueeee, A.E. Oei??eyi, A.N. Aaoo?a). 5. Aeoeaiay oe?o?ae/aneay oaeoeea a ea/aiee ?aiaaie eioaeoeee o aieueiuo naoa?iui aeeaaaoii.// I?iaeaie e??ia?ieia??.-1998.-?3.- N. 63-67. (Ni?aaaoi?e: Aaeeaioeueeee I.I., Oaii O.?., Aaoo?a A.N., Aaeeaioeueeee I.I., Aoaaeia ?.?.). 6. I?ioeeaeoeea e ea/aiea aiieiuo ineiaeiaiee iineaiia?aoeeiiiuo ?ai n i?eiaiaieai iaiiiai ay?iciey “Ae?ienecieue” a yenia?eiaioa.// Iaoeiai-i?aeoe/ia eiioa?aioe?y o??o?a?a Oe?a?ie “Aiieii-naioe/aneea ineiaeiaiey a iaioeiaeiie oe?o?aee”, Oa?e?a, 12-14 ea?oiy 1995, n. 247-249 (Ni?aaaoi?e: I.I. Aaeeaioeueeee, A.E. Oei??eyi). AIIOAOe?ss Aeoaaiei A.A. I?io?eaeoeea oa e?eoaaiiy ?aiiai? ?ioaeoe?? i?e oeoe?iaiio ae?aaao? c aeei?enoaiiyi “Ae?ienecieth”.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.03 – o??o?a?y.- Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao. Oa?e?a, 1999. Ia i?aenoaa? aenia?eiaioaeueiiai oa ee?i?/iiai aeine?aeaeaiue ?ic?iaeaia iaoiaeeea, yea aeicaiey? iie?ioeoe ?acoeueoaoe o??o?a?/iiai e?eoaaiiy ai?eii-iae?ioe/ieo caoai?thaaiue i'yeeo oeaiei o oai?eo ia oeoe?iaee ae?aaao I ? II oei?a c iayaieie iciaeaie ae?aaaoe/ieo aia?iiao?e. Aeiaaaeaia aoaeoeai?noue ii?aeiaiiy aeoeaiiai ae?aioaaiiy caoeoi? i?e?iaii-caa?oaeiaii? ?aie c aaaaeaiiyi a ?? ii?iaeieio i?iiiai aa?icieth c ae?ieneaeeiii “Ae?ienecieue”. Aeei?enoaiiy i?aia?aoa ? ia?niaeoeaiei i?e ae?aioaaii? aeeaieeo ?aiiaeo ii?iaeiei ? eaiae?a ?c neeaaeiith eiio?ao?aoe??th. I?noeaaa e?eoaaiiy ai?eii? ?aie ?c canoinoaaiiyi “Ae?ienecieth” a oiiaao iaia'yceiai? aioeae?aaaoe/ii? oa?ai?? oa eiiieaenii? ei?aeoe?? aeyaeaieo ii?ooaiue o nenoai? aiiainoaco ni?ey? iaoneeaaeiaiiio ia?aa?ao ?aiiaiai i?ioeano, iiia?aaeaeaiith ?icaeoeo ?aiiai? i?e?ioei?e, cieaeaiith ??aiy oa o?eaaeino? ?ioieneeaoe??. Oea aeicaiey? nooo?ai iie?ioeoe ?acoeueoaoe e?eoaaiiy ai?eii? ?ioaeoe?? o oai?eo ia oeoe?iaee ae?aaao. Eeth/iai neiaa: oeoe?iaee aeiaaao, ae?aaaoe/ia aia?iiao?y; ai?eia ?ioaeoe?y, e?eoaaiiy, i?io?eaeoeea, “Ae?ienecieue”. Aeoaaiei A.A. I?ioeeaeoeea e ea/aiea ?aiaaie eioaeoeee i?e naoa?iii aeeaaaoa n eniieueciaaieai “Aeeieneciey”.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.03 – oe?o?aey.- Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao. Oa?ueeia, 1999. Ia iniiaaiee yenia?eiaioaeueiiai e eeeie/aneiai enneaaeiaaiee ?ac?aaioaia iaoiaeeea, iicaieythuay oeo/oeoue ?acoeueoaou oe?o?ae/aneiai ea/aiey aiieii-iae?ioe/aneeo caaieaaaiee iyaeeo oeaiae o aieueiuo naoa?iui aeeaaaoii I e II oeiia n io/?oeeauie i?eciaeaie aeeaaaoe/aneeo aiaeiiaoee. Aeieacaia yooaeoeaiinoue ni/aoaiey aeoeaiiai ae?aie?iaaiey caoeoie iee?iaii-caa?yci?iiie ?aiu n aaaaeaieai a ia? ii ae?aiaaeo iaiiiai ay?iciey n aeeieneaeeiii “Aeeienecieue”. Eniieueciaaiea i?aia?aoa ia?niaeoeaii i?e ae?aie?iaaiee aeoaieeo ?aiaauo iieinoae e eaiaeia ni neiaeiie eiioeao?aoeeae. Ianoiia ea/aiea aiieiie ?aiu n i?eiaiaieai “Aeeieneciey”, a oneiaeyo iaycaoaeueiie aioeaeeaaaoe/aneie oa?aiee e eiiieaeniie ei??aeoeee auyaeaiiuo ia?ooaiee a nenoaia aiiainoaca, niinianoaoao iaineiaei?iiiio oa/aieth ?aiaaiai i?ioeanna, i?aaeoi?aaeaeaieth ?acaeoey ?aiaaie iee?ioei?u, nieaeaieth o?iaiy e i?iaeieaeeoaeueiinoe eioieneeaoeee. Yoi iicaieyao nouanoaaiii oeo/oeoue ?acoeueoaou ea/aiey aiieiie eioaeoeee o aieueiuo naoa?iui aeeaaaoii. Eeth/aaua neiaa: naoa?iue aeeaaao, aeeaaaoe/aneay aiaeiiaoey; aiieiay eioaeoeey, ea/aiea, i?ioeeaeoeea, “Aeeienecieue”. Dubenko V.V. “Dioxysol” application for comprehensive prevention and treatment of the diabetics' wound infection. - Manuscript. Thesis for the scientific degree of candidate of medical sciences by speciality surgery - 14.01.03. Medical State University, Kharkov, 1999. The thesis deals with the problem of improving the results of treatment and prevention of the wound infection for diabetic patients. All patients have signs of diabetic angiopathy. On the basis of experimental and clinical researches a new method for local chemotherapy correction of wound healing processes has been developed and introduced into surgery practice. This method combines an active draining of the microbe-contaminated and purulent wound with “Dioxysol” foamy spray application into the wound through the drain. The antibacterial effect of “Dioxysol” was experimentally tested on “basic” types of purulent infection microbes in vitro and in vivo. The method of registration of the quantitative growth of microbes and the method of diffusion of the preparation into agar were experimentally used in vitro. The following three models were used for experiments in vivo: 1) purulent wound; 2) soft tissues abscess; 3) the microbe contaminated lacerated-crushed wound when the primary surgical treatment was delayed. The results of experiments have shown that application of “Dioxysol” progressively eliminates microbial agent and stabilizes the wound healing process. “Dioxysol” has proved to be highly effective for treatment and prophylaxis of purulent wound. The clinical part of the work includes the analysis of investigation results for types I and II diabetes mellitus patients. The patients had different kinds of soft tissues purulent destructive inflammation. The treatment was based on the principle of active surgical tactics. The program of treatment included antidiabetic therapy and complex correction in homeostasis system irregularities. To avoid the purulent infection after the operation the wound was actively drained and antimicrobe preparations were locally applied. To estimate the effectiveness of the treatment proposed all the patients were subdivided into two groups: the main one and the comparative one. The patients of the main group got active draining of the wound in combination with “Dioxysol” application into the wound through the drain. Depending on the form of diabetes and the size of purulent destructive inflammation all the patients were subdivided into three clinical subgroups. 1 subgroup was formed of patients with abscess-type purulent inflammation. 2 subgroup included patients with phlegmon-type purulent inflammation. And 3 subgroup was formed of patients with gangrenous extremities. For 1 and 2 subgroup patients abscess and phlegmon-type suppuration were radically cut out or incised, then necrectomia and step-by-step sanation of the wound followed. And if the state of the wound permitted the primary-delayed or secondary stitches were put in. The 3 subgroup patients had the gangrenous extremities amputated. Active draining of the wound and “Dioxysol” application for 1 and 2 subgroup patients at early postoperational period has proved to be effective and considerably decreased wound microbe contamination. No signs of local inflammation and intoxication as well as decompensation of diabetes mellitus were observed. Combination of active draining of the amputated stump with “Dioxysol” foamy spray application into the wound channel for 3 subgroup patients when hyperglycemia and homeostasis system were adequately corrected reduced the level and duration of intoxication, prevented wound suppuration and decompensation of diabetes mellitus. Complex clinical and laboratory examination of patients showed improvement of the cell and humoral immunity, nonspecific resistibility of organism, activity of phagocytose and morphological and functional condition of blood microcirculation. The characteristics of protein and carbohydrate metabolism as well as homeostasis were stabilized. The characteristics of leukocyte system formula were improved. The results of bacteriological, cytological and hystological investigations showed reliable suppression of wound infection and trouble-free process of wound healing. Results of surgical treatment of purulrnt destructive inflammation in soft tissues for diabetic patients showed that combination of active draining of the postoperated wound with “Dioxysol” application when the center of purulent infection has been radically extracted provided a completely clean wound free of purulent infection when healing process started. Adequate compensation of hyperglycemia, complex correction of homeostasis irregularities and prevention of local inflammation of the wound at an early stage ensures quick decrease of the level and duration of intoxication and stabilize patients' diabetes. The complex influence on the mechanism of local purulent inflammation leads to the active suppresion of the factors which slow down the healing process. So the risk of purulent complication at the early postoperational period has been considerably reduced. Early spitching of the microbe contaminated or even purulent postoperational wound become possible and in most cases it permits to give up prophylactic use of antibiotics. The process of patients healing is accelerated and the period of the treatment at the hospital is reduced. Key words: diabetes mellitus, diabetic angiopathy, purulent infection, treatment, prophylaxis, “Dioxysol”.

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