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Профілактика гемостазіологічних порушень при передчасних пологах, ускладнених передчасним розривом плідних оболонок: Автореф. дис… канд. мед. наук /

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I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

Ianoa?aiei Eaii?ae Aiaoie?eiae/

OAeE: 618.39-005.2-084

I?IO?EAEOEEA AAIINOAC?IEIA?*IEO II?OOAIUe I?E IA?AAe*ANIEO IIEIAAO,
ONEEAAeIAIEO IA?AAe*ANIEI ?IC?EAII IE?AeIEO IAIEIIIE

14.01.01 – aeooa?noai ? a?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oe?a?inuee?e iaaee/i?e noiiaoieia?/i?e aeaaeai?? IIC
Oe?a?ie

Iaoeiaee ea??aiee:aeieoi? iaaee/ieo iaoe, i?ioani? A?iiiaa Aioii?ia
Iaea??aia, caa.eaoaae?e aeooa?noaa ? a?iaeieia?? Oe?a?inueei? iaaee/ii?
noiiaoieia?/ii? aeaaeai??

Io?oe?ei? iiiiaioe:aeieoi? iaaee/ieo iaoe, i?ioani? Ua?aaeiaa Aaeaioeia
Aanee?aia, caa?aeoaa/ eaoaae?e aeooa?noaa ? a?iaeieia?? ?1 Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a

aeieoi? iaaee/ieo iaoe Eeiei Ienaia Iao??aia, i?ioani? eaoaae?e
aeooa?noaa ? a?iaeieia?? ?1 Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo

I?ia?aeia onoaiiaa:?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII
Oe?a?ie, a?aeae?eaiiy iaoieia?? aaa?oiino? oa iieia?a

Caoeno a?aeaoaeaoueny ” 11 ” aa?aciy 1999 ?. i 13-30 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.01 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca aae?anith: 310022, i. Oa?e?a,
i?.Eai?ia 4

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ca aae?anith: 310022, i. Oa?e?a,
i?.Eai?ia 4

Aaoi?aoa?ao ?ic?neaiee “ 9 ” n?/iy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

e.i.i., aeioeaio
I.I.Oaiueei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue oaie. Na?aae ??cieo aeae?a aeooa?nueei? iaoieia??
aaii?aa?/i? oneeaaeiai-iy aanoaoe?eiiai i?ioeano caeiathoue iaeia c
aaaeo/eo i?noeue. Aeooaeuei?noue oe??? i?iaeaie iao-iiaeaia aaaiiei
aianeii ?? a no?oeoo?o iaoa?einueei? nia?oiino?.

Aeooa?nuee? e?iaioa/?, iia’ycai? c ii?ooaiiyi i?e?icn?aeaiiy e?ia?,
caeiathoue iaeia c ia?oeo i?noeue na?aae i?e/ei iaoa?einueei?
eaoaeueiino? a?eueoino? ?icaeiooeo e?a?i na?oo (I.A.?ai?ia, 1986;
A.E.Eaiei ? ni?aaao., 1990; O.?.A?eie?eieoeueea, 1991; A.Ae.Iaeaoea??y ?
ni?aaao., 1993; A.?.A?euaiei ? ni?aaao., 1997; J.H.Rand et al., 1985).

Iaaiee i?ia?an a aeai?e i?iaeai? aeinyaiooi caaaeyee ?ic?iaoe? ?
ai?iaaaeaeaiith a aeo-oa?nueeo i?aeoeeo iiiyooy “a?oie ?eceeo” ii
?icaeoeo e?iaioa/?, c’ynoaaiith iiaeo eaioeth-a?a iaoiaaiaco, iaoiae?a
ae?aaiinoeee oa i?io?eaeoeee neiae?iio aeenai?iiaaiiai
aioo??oiuei-noaeeiiiai cn?aeaiiy (A.Ae.Iaeaoea??y ? ni?aaao., 1981,
1991; A.I.I?uaiei, 1988; A.N.A?oaii-iia ? ni?aaao., 1993; A.A.Sharp et
al., 1983; R.O.Norman et al., 1985).

Oiciieiai/ii ciiie iiae /an aaaioiinoi aiaeiinyoueny aei oeiiaeo i?iyaia
neiae?iio caaaeue-ii? oee?eoeyoi?ii? aaeaioaoei? aei aaaioiinoi i
iieiaia (A.Ae.Iaeaoea??y i niiaaao.,1985; A.I.Na-aaeue?aa i niiaaao.,
1991; S.Bondurant et al., 1984). Aaaeeeaith eaieith iaoiaaiaco
/eneaiieo oneeaaeiaiue a aeooa?nueeie i?aeoeoei ? ii?ooaiiy a nenoaii
aaiinoaco ia c?acie neiae?iio AeAC (I.A.??i?ia i niiaaao.,1985;
A.Ae.Iaeaoea??y i niiaaao., 1986; A.I.Na?ia i niiaaao.,1987;
A.N.A?oaiiiia i niiaaao.,1993; A.E.Aeeaiacyi,1995; L.M.Talbert et
al., 1979; R.D’Anna et al., 1987; Z.Marozio et al., 1987).

Caeeoa?oueny aenieei aiaenioie e?iaioa/ i?e ia?aae/anieo iieiaao (II),
yeee eiee-aa?oueny aiae 2,5% aei 20,2% (A.I.Aieoa?a i niiaaao., 1980;
A.I.Neaeaeueieeiaa, 1986; E.A.Oeii-oaiei i niiaaao., 1987; I.A.??i?ia,
1988; W.Hathway et al., 1978; I.M.Foiidart et al., 1984). A naith /a?ao,
ia?aae/anii iieiae c ia?aae/aniei ?ic?eaii ieiaeieo iaieiiie (I?II) a
38% oneeaaeiththoueny iaoieiai/ieie e?iaioa/aie (E.A.Oeiioaiei i
niiaaao., 1984; A.O.Ee?/oe i niiaaao., 1991; I.O.Ieoaeeaiei, 1994;
I.I.A?eai?aiei i niiaaao., 1995; S.Ferrari et al., 1981, T.C.Inglish et
al., 1982).

Iniaeeai aaeeei? oaaae caneoaiao? canoinoaaiiy iaiaaeeeaiaioicieo
iaoiae?a eieoaai-iy a aeooa?nueeie i?aeoeoei, ye? ia iathoue iiai/iiai
aieeao ia i?aaiici iaoa?i i ieiaea (E.Ae.Caieaiiaa, 1989; A.E.Nieiaeiaa
i niiaaao., 1990; I.N.Cieiooo?i i niiaaao., 1992; E.A.Ei-eiiae/oe i
niiaaao., 1993; I.Lackinger, 1989; B.A.Blanchard et al., 1993). Iaeiei c
oaeeo iaoiaeia ? aeei?enoaiiy iecueeiaia?aaoe/iiai eaca?iiai
aei?iiiithaaiiy, yea ia aieeaa? iaaaoeaii ia ieiae, c oniioii
canoiniao?oueny i?e eieoaaiii aanoicia, aeno?aaai?oaeueii? iaoieiai?
aaaio-ieo oa oneeaaeiaiiyo iiney?iaeiaiai ia?iiaeo. A e?oa?aoo?? ia
inio? ?aeeii? aeoiee i?i aieea iecueeiiioaineaiiai eaca?iiai i?iiaiy ia
nenoaio aaiinoaco. O ca’yceo c oeei, aea/aiiy noaio nenoaie aaiinoaco
i?e II i II c I?II oa ?ic?iaea ?aoeiiiaeueii? iaoiaeeee eaca?ii?
oioiaiiaei? ia nenoaio cniaeaiiy e?iai ? aeooaeueieie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoeiy ?
o?aa-iaioii eiiieaenii? oaie “Aieea ciii aiiainoaco aioo?ioiueiai
na?aaeiaeua i?aaiicio aa-aioieo i?e aeooa?nueeie oa aeno?aaaiioaeueiie
iaoieiai? i iaoiaeia ?iaei?ic?ioaiiy ia ia?aaia aaaioiinoi, iieiaia,
iineyiieiaiaiai ia?iiaeo, noai ieiaea i iiaiia?iaeaeaiiai oa ei?aeoeiy
ae-yaeaieo ii?ooaiue”, yea aeeiio?oueny ia eaoaae?i aeooa?noaa i
aiiaeieiai? Oe?aiinueei? iaaee/-ii? noiiaoieiai/ii? aeaaeaii? (iiia?
aea?aeaaii? ?a?no?aoei? 019600451).

Iaoa aeineiaeaeaiiy. C’ynoaaiiy iniaeeainoae iaoiaaiaco
aaiinoac?ieia?/ieo oneeaae-iaiue ia?aae/anieo iieia?a oa ?ic?iaea
iaiaaeeeaiaioicieo iaoiae?a aieeao ia aaiinoac i?e II.

Caaea/i aeineiaeaeaiiy:

1. Aea/eoe iniaeeainoi aiaiiaco, ia?aaiao aaaioiinoi o aeiiie c
ia?aae/anieie iieiaa-ie, a oiio /enei c ia?aae/anieie iieiaaie oa
ia?aae/aniei ?ic?eaii ieiaeieo iaieiiie, i ae-cia/eoe oaeoi?e, ui
ni?eythoue io aeieeiaiith.

2. C’ynoaaoe iniaeeainoi nenoaie aaiinoaco i?e caa?ici ia?aae/anieo
iieiaia oa ia?aae-/anieo iieiaao c ia?aae/aniei ?ic?eaii ieiaeieo
iaieiiie.

3. Aecia/eoe ciiie aa?aaaoiiai noaio e?iai i?e canoinoaaiii
o?aaeeoeieiii oa?iaeioa-?aii? caa?ice ia?aae/anieo iieiaia oa i?e II.

4. ?ic?iaeoe aeinooiio oa aacia/io iaoiaeeeo iecueeiiioaineaiiai
eaca?iiai aieeao ia aaiinoac i?e II oa I?II c iaoith i?ioieaeoeee
aioo?ioiueinoaeeiiiai iie?icniaeaiiy e?iai.

5. Aea/eoe aieea ciaiioiueiai iecueeiiioaineaiiai eaca?iiai
ii?iiiithaaiiy e?iai ia aa?aaaoiee noai e?ia? oa aioo?ioiueioo?iaiee
ie?ae i?e caa?ici ia?aae/anieo iieiaia ? ia?aae-/anieo iieiaao c
ia?aae/aniei ?ic?eaii ieiaeieo iaieiiie.

6. Aecia/eoe noai oiiono iaoee i eiai ciiie i?e i?iaaaeaiii
iecueeiiioaineaiiai ea-ca?iiai aieeao a iaeanoi neiiea?ioeaeii? ciie.

Iaoeiaa iiaecia. Ia no/aniiio ?iaii iiaeeaeai? oyaeaiiy i?i iniaeeainoi
aaiinoa-co i?e caa?ic? ia?aae/anieo iieiaia i i?e ia?aae/anieo iieiaao c
ia?aae/aniei ?ic?eaii iei-aeiaeo iaieiiie. Aia?oa aeyaeai?
aaiinoac?ieia?/i? ia?ea?e aeiee?i?/ieo iciae II.

Iaoeiai iaa?oioiaaia iaiaoiaeiinoue i?iaaaeaiiy ciaiioiueiai
iecueeiiioaineaiiai ea-ca?iiai ii?ii?ithaaiiy i?e aeieeiii/ieo i?iyaao
caa?ice ia?aae/anieo iieiaia i ia?aae/anieo iieiaao c I?II, yea
iiaeaeuo? eiiiainaoi?ii oa aaeaioaoeieii iiaeeeainoi nenoaie aaiinoaco.

I?aeoe/ia cia/aiiy. Aeyaeai? ii?ooaiiy aaiinoaco i?e ia?aae/anieo
iieiaao aei-caieeee noi?ioaaoe na?aae aaa?oieo ae?iie a?oio ?eceeo, yea
iio?aao? ei?eaoth/i? aaiinoac oa?ai??.

Cai?iiiiiaaii aeey caeeaae?a i?aeoe/ii? iaaeeoeeie i?ei?iyoe a eiiieaen?
c o?aaeeoe?e-ieie iaoiaeaie ciai?oi? iecueei?ioaineaia eaca?ia
ii?ii?ithaaiiy e?ia? a neiiea?ioeaei?e cii? c iaoith i?io?eaeoeee
ia?aae/anieo iieia?a, ia?aae/aniiai ?ic?eao ie?aeiiai i?oo?a, ciaioaiiy
/anoioe iaoieia?/ii? e?iaiao?aoe a iieiaao i?e oeeo oneeaaeiaiiyo
aanoaoe?eiiai i?ioeano.

?ic?iaeaii aeinooiiee aeey oe?iei? i?aeoeee niinia i?ioieaeoeee
eiaaoeiiaoe/ieo e?iaioa/ i?e ia?aae/anieo iieiaao (iaoaio Oe?a?ie ia
aeiaoiae ?21344A), yeee ia? ?yae ia?aaaa: a?aenooi?noue i?ioeiieacaiue,
eaae?noue aeei?enoaiiy, a?aeiinia aeaoaaecia, a?aenooi?noue iaaaoeaii?
iaaeeeaiaioicii? ae?? ia aioo??oiueioo?iaiee ie?ae ? aaa?oio,
ia?iaaceai?noue, ii-aea?eia ae?y (ye ia no?oi e?ia?, ui ?ooa?oueny ii
niii?e a?oa???, oae ? ia ?aoeaeniaaiio neiiea-?ioeaeio ciio) eaca?iiai
i?iiaiy, a?aenooi?noue iaiao?aeiino? eiaaoeieia?/iiai eiio?ieth.

Oei ?aeiiaiaeaoeii ai?iaaaeaeaii a ?iaioo Iieoaanueeiai iinueeiai
iieiaiaiai aoaeeieo oa iieiaiaeo aiaeaeieaiue Eoaainueei?,
Oi?ieuenueei?, Ciiueeianueei? Oe?E Iieoaanueei? iaeanoi.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii naiino?eii iaa?oioiaai? iaoa
oa caaaeai-iy aeine?aeaeaiiy, aea?ai? aaeaeaaoi? iaoiaee/i? caoiaee,
i?iaaaeai? iaoeia? aeine?aeaeaiiy, ianoa-aeai? aaa?oi? ca aeiiiiiaith
no/anieo iaoiae?a ae?aaiinoeee, i?iaaaeai? aaiinoac?ieia?/i?
aei-ne?aeaeaiiy o ae?iie c ia?aae/anieie iieiaaie, ?ic?iaeaia a?oia
?eceeo oa iaoeiai iaa?oioi-aaii iaiaaeeeaiaioiciee iaoiae i?io?eaeoeee
aiianoac?ieia?/ieo ii?ooaiue. Aaoi? i?eeiaa iniaenoo o/anoue o
ai?iaaaeaeaii? ?acoeueoao?a aeine?aeaeaiiy a i?aeoe/io iaaeeoeeio.

Ai?iaaoeiy ?acoeueoaoia aeena?oaoeii. Iaoa?iaee i iniiaii iieiaeaiiy
aeena?oaoei? aoee i?aaenoaaeaii ia O c’?caei aeooa?ia-aiiaeieiaia
Oe?a?ie (i.Iaeana, 1996 ?ie), iiaeia?iaeiie eii-oa?aioei? “Oic?ieiaiy i
iaoieiaiy iioiioaoo, aaiinoaco, ia?aeeniiai ieeneaiiy eiiiaeia”
(i.Iieoaaa, 1997 ?ie), iaoeiai-i?aeoe/ieo eiioa?aioeiyo Iieoaanueeiai
iinueeiai eeiii/iiai iieiaiaiai aoaeeieo (i.Iieoaaa, 1997 ?ie). ?iaioa
caneooaia ia Iaoeiaie ?aaei ii ai?iaaoei? aeena?oaoeie Oe?aiinueei?
iaaee/ii? noiiaoieiai/ii? aeaaeaii?.

Ioaeieaoei?. Ca iaoa?iaeaie aeineiaeaeaiue iioaeieiaaii 7 ae?oeiaaieo
?iaio, c ieo 4 aac niiaaaoi?ia. 5 i?aoeue iioaeieiaaii o aeaeyaei oac; 2
noaooi – o aeo?iaei “Aanoiee i?iaeai aei-eiaee e iaaeeoeeiu”. Io?eiaiee
iaoaio Oe?a?ie ia aeiaoiae ?21344A aiae 02.12.97 ?ieo “Nii-nia
i?ioieaeoeee eiaaoeiiaoe/ieo e?iaioa/ i?e ia?aae/anieo iieiaao”.

Ianya oa no?oeoo?a aeena?oaoeii?. Aeena?oaoeiy neeaaea?oueny c anooio,
iaeyaeo eioa?aoo?e, 2 ?icaeieia, a yeeo iienaii iaoa?iaee oa iaoiaee
aeineiaeaeaiiy i caaaeueia eeiii/ia oa?aeoa?en-oeea ianoaaeaieo aeiiie,
2 ?icaeieia aeanieo aeineiaeaeaiue, caeeth/aiiy, aeniiaeia, i?aeoe/ieo
?aeiiaiaeaoeie i nieneo aeei?enoaii? eioa?aoo?e, yeee neeaaeaaoueny c
207 aeaea?ae (a oiio /en-ei 69 aaoi?ia aeaeueiueiai ca?oaiaeaey). Ia’?i
aeena?oaoei? – 121 coi?iiea oaenoo, a oiio /enei 23 oaaeeoei, 9
iaethieia.

INIIAIEE CIINO ?IAIOE

Iaoa?iaee i iaoiaee aeineiaeaeaiiy. ?iaioa aeeiiaia ia aaci eaoaae?e
aeooa?noaa i ai-iaeieia?, Oeaio?aeueii? iaoeiai-aeineiaeii? eaai?aoi?i?
Oe?a?inueei? iaaee/ii? noiiaoieiai/ii? aeaaeaii?, oa Iieoaanueeiai
iinueeiai eeiii/iiai iieiaiaiai aoaeeieo.

Aeey ae?ioaiiy iinoaaeaieo caaaeaiue aoei i?iaiaeiciaaii 250 inoi?ie
iieiaia (a?oia-iee iaoa?iae), aeineiaeaeaii ia?aaia aaaioiinoi i iieiaia
o 193 aeiiie, yeei aoee i?iaaaeai? oeueo?acaoeia?, ea?ae?ioieia?ao?/i?
oa aaiinoac?ieia?/i? aeine?aeaeaiiy. C ieo: 61 ae?iea c I?II a oa?i?i?
aaa?oiino? 29-36 oeaei?a – iniiaia a?oia (IA), 31-?e c ieo i?iaiaeeeanue
eiiieaenia oa?ai?y, yea aeeth/aea ii?yae c aeei?enoaiiyi
aioeaaeoa??aeueieo i?aia?ao?a, niaciie?oee?a, i?aia?ao?a iie?iooth/eo
iaoeiai-ieaoeaioa?iee e?iaiia?a, cania?a i?io?eaeoeee NAe? iei-aea,
ciai?oi? iecueei?ioaineaia eaca?ia ii?ii?ithaaiiy e?ia? (CIEIE) – ?
iniiaia a?oia (?-IA). 30 – c ia?aae/aniei aeeeooyi iaaeieiie?aeii? aiaee
a eiiieaeni?e oa?ai?? io?eioaaee ani???i – ? a?oia ii??aiyiiy (?-IA); 40
?iae?eue a ia?oiio ia??iae? iaoneeaaeiaieo nai?/anieo iieia?a ooai?eee
eiio?ieueio a?oio (EA); 32 – a ? ia??iae? ia?aae/anieo iieia?a c oe?eei
ie?ae-iei i?oo?ii – a?oia ii??aiyiiy (AI); 30 aaa?oieo c aeiee?i?/ieie
iciaeaie caa?ice II, 15 c yeeo io?eioaaee o?aaeeoe?eio caa??aath/o
aaa?oi?noue oa?ai?th c canoinoaaiiyi ani???ia – ?? a?oia ii??aiyiiy
(??-AI) oa 15 – a eiiieaen? caa??aath/i? oa?ai?? i?iaiaeeeinue CIEIE –
?? iniiaia a?oia (??-IA).

30 caei?iaeo aaa?oieo ae?iie a 29-36 oeaei?a ooai?eee ? eiio?ieueio
a?oio (?-EA). I?i-aiae?ciaai? iniaeeaino? ?icaeoeo 61 iiaiia?iaeaeaiiai.
Ii?yae ic caaaeueiieeiii/iei ianoa-aeaiiyi aaaioieo i ii?iaeieue o
ianoaaeaieo aeiiie i?iaiaeeeenue aaiinoaciieiai/ii aeineiaeaeaiiy ye
iiae /an aaaioiinoi, oae i iiney I?II oa a I ia?iiaei ?iaeia. Aea/aee
o?iiaioeeoa?io, i?i-eiaaoeyioio oa oia?iiieioe/io eaiee aaiinoaco ca
iaoiaeeeaie I.A.Eioiaueeiai?, C.Ae.Oa-aei?iai? (1966); A.A.Aiae?i?iei,
A.I.Aaeoaee, C.N.Aa?eaaaia, A.E.Aieueaeaa?aa (1980); I.A.Ea?a-aaniai?,
E.A.Eaoiai? (1981).

Ea?aeiioieia?aoiy i?iaiaeeeanue oaoaeueiei aiiiiiioi?ii AIO 9141. Noai
aioo?ioiuei-oo?iaiiai ieiaea ioeiithaaee oeyoii aiae?co EOA ca oeaeith
W.Fisher oa niiaaaoi?ia (1976). Oeueo?acaoeiaa aeineiaeaeaiy
i?iaiaeeeinue aia?aoii “Combison 320-5 KRETZ TECHNIK” (Aano?iy).

Aeey i?ioieaeoeee oa ei?aeoei? aaiinoaciieiai/ieo ii?ooaiue i?e caa?ici
II oa II c I?II aeei?enoiaoaaany ?ic?iaeaiee ia iiaenoaai iaoiaeeee
?.A.E?aniiiieuenueeiai (1988) “Niinia i?ioieaeoeee aaiinoaciieiai/ieo
ii?ooaiue i?e II, oneeaaeiaieo I?II” (iaoaio Oe?a?ie ia aeiaoiae
?21344A) oeyoii ciaiioiueiai iecueeiiioaineaiiai eaca?iiai
ii?iii-ithaaiiy e?iai a neiiea?ioeaeiie ciii. Aeei?enoiaoaaee
aaeie-iaiiiaee eaca?iee aia?ao “AOIEE”, noai?aiee ia aaci EAI-3. ?aaeei
?iaioe: aeiaaeeia oaeei 0,63 iei, ?aaeei aei?i-iiithaaiiy –
aacia?a?aiee, iiooaeiinoue aei?iiiithaaiiy ia ae-oiaei 10 iAo, /an
aeniiceoeii – 600n. I?iaaaeaii 416 naainia.

Io?eiaii ?acoeueoaoe noaoenoe/ii ia?iaeaii iaoiaeaie aa?iaoeieii?
noaoenoeee c aeei-?enoaiiyi e?eoa?ith No’thaeaioa – Oioa?a (A.I.Cthcii,
1995).

?ACOEUeOAOE AeINEIAeAEAIUe OA ?O IAAIAI?AIIss

Ia iiaenoaai aea/aiiy a?o?aiiai iaoa?iaeo aiaecia/aii, ui aeinoiai?ii
/anoioa I?II i?e iaaeiiioaiie aaaioiinoi ia?aaeoaaee aiaiiy (46,0±7,0%),
caa?ica ia?a?eaaiiy aaaioiinoi (46,0±7,0%), A?AI (16,0±5,2%),
iiaeiiao?eo (10,0±4,6%), eieueiio (30,0±6,5%), aaaaoiaiaeaey
(16,0±5,2%). Noai aeioae, ui ia?iaeeeenue i?e I?II a 29-36 oeaeiia
aaaioiinoi, aoa ioeiiaiee ca oeaeith Aiaa? ia 2,4 aaea ( ?0,25?>0,5O?iiaioeeo?a270,1±9,3298,2±
8,4 ?0,1?20,5*an?0,122,1±0,48?1>0,5Aa?aaaoe???10,5*an?0,110,8±0,14?1>0,5(oa)?10,25Eoo?0,5(a?aae)?10,25(ni)?10,25Ci?ie?0,529,6±0,39?20,25?>0,5
Oeeo?eaoe??84,6±3,2781,2±3,29?>0,2578,4±3,46?>0,180,3±3,44?1>0,581,8±3,2
1?1>0,5 Ieaciu?1>0,5?2>0,5?2>0,25(n)?3>0,5I?io?iia?-?>0,1?>0,25iiaee
/an
18,6±1,0416,9±1,06?>0,2515,3±0,58?0,517,4±1,08?1>0,5
(n)?1>0,1?2>0,25?20,5O?iia?ii-?0
,1
(n)?10,1?20,25Aeoeai?noue?>0,25?>0,1aioeo?ii-26,8±1,0730
,3±1,16?0,1a?ia
III?10,1?20,5 oe?y
o?a??-4,2±0,173,2±0,21?0,14,7±0,12?10,5?20,1169,9±5,80?0,1189,2±4,
48?1>0,5Aoe?i?a?10,25 I?ei?oea:? –
aeinoia??i?noue ??cieoe? a ii??aiyii? c iieacieeaie o
ae?iie c naia/anieie iieiaaie;?1 – aeinoia??i?noue ??cieoe? a
ii??aiyii? c iieacieeaie o ae?iie a 1-io ia??iae? II n
oe?eei ie?aeiei i?oo?ii;?2 – aenoia??i?noue ??cieoe? a ii??aiyii? c
iieacieeaie o ae?iie aei ii/aoeo e?eoaaiiy;?3 – aeinoia??i?noue
??cieoe? a ii??aiyii? c iieacieeaie o ae?iie i?ney o?aaeeoe?eiiai
e?eoaaiiy (ani???iii).

Aiaeicoth/e iniaeeainoi ia?aaiao ?iaeia i iiney?iaeiaiai ia?iiaeo o
ianoaaeaieo aeiiie aiaeii/aii; ui a a?oi? ae?iie, yeeo e?eoaaee ca
aeiiiiiaith CIEIE ii??aiyii c a?oiith, yeeo e?eoaaee c aeei?enoaiiyi
ani???io, iaea i?noea iaioa e?euee?noue oneeaaeiaiue. Oae, /anoioa
neaaeino? ?iaeiai? ae?yeueiino? cieceeanue iaeaea a 2 ?ace (c 6,7% aei
3,2%; ?

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