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Пошук ефективних протиаритмічних засобів серед нових похідних діамінодифенілу та дибензодіазепіну: Автореф. дис… канд. мед. наук / І.В. Данильчук, А

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AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OA?IAEIEIA?? OA OIENEEIEIA??

Aeaieeue/oe ?ai? A?oae?eiae/

OAeE 615.22:547.553.2

IIOOE AOAEOEAIEO I?IOEA?EOI?*IEO CANIA?A

NA?AAe IIAEO IIO?AeIEO Ae?AI?IIAeEOAI?EO OA AeEAAICIAe?ACAI?IO

14.03.05 – oa?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a A?iieoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I.?. Ie?iaiaa IIC Oe?a?ie.

Iaoeiaee ea??aiee: caneoaeaiee ae?y/ aeui? oeiee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, Noiey?/oe Ieaenaiae? Ieaenaiae?iae/, A?iieoeueeee
aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.?. Ie?iaiaa IIC Oe?a?ie,
i?ioani? eaoaae?e oa?iaeieia??.

.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, O?aiae Aieiaeeie?
Aaiaaeeeoiae/, ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie,
aieiaiee iaoeiaee ni?a?ia?oiee;

aeieoi? iaaee/ieo iaoe, Ai?/aeiaa Iaae?y Ieaenaiae??aia, Iaoe?iiaeueiee
iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey, i?ioani? eaoaae?e
oa?iaeieia??.

I?ia?aeia onoaiiaa: Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
eaoaae?a caaaeueii? oa ee?i?/ii? oa?iaeieia??.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “__13__” aeiaoiy 1999 ?ieo i “15”
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.550.01 i?e
?inoeooo? oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, i.Ee?a,
aoe. A.Iiouea, 14)

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, i.Ee?a, aoe.
A.Iiouea, 14)

Aaoi?aoa?ao ?ic?neaiee “10”aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee, e.a.i.
?.A. Aeaiiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aeey e?eoaaiiy ii?ooaiue na?oeaaiai ?eoio a
ee?i?/i?e i?aeoeoe? ca?ac aeei?enoiao?oueny aeineoue aaeeea a?oia
i?ioea?eoi?/ieo cania?a, ye? a?aeiinyoueny aei ??cieo eean?a o?i?/ieo
niieoe (I.A. Eaaa?eia, 1994; I.A. Iaco?, 1994; I.N. Eooaeianeee, 1998;
I.Ae. Iaoeianeee, 1998).

Iaeiae, iacaaaeath/e ia oe?ieee aea?? aioea?eoi?e?a, i?iaeaia ai?ioueae
c a?eoi?yie nueiaiaei? ua ia ae??oaia.

A?eoi?y – oea eeoa neiioii, ui aeaco? ia ii?ooaiiy aeanoeainoae
i?iea?aeo. Oe? ii?ooaiiy iiaeooue ianooieoe a ?acoeueoao? caiaeueieo,
aeeno?io?/ieo, ?oai?/ieo, oiene/ieo a?aaeaiue i?iea?aeo, ?iceaaeo
ia?aiai? oa ai?iiiaeueii? ?aaoeyoe?? na?oeaai? ae?yeueiino? oa ?ioeo
i?e/ei. Iane?aeeii ae?? oeeo oaeoi??a ? ii?ooaiiy ii?iaeueiiai
o?ainii?oo ?ii?a a ee?oeiao i?ia?aeii? nenoaie na?oey, ui i?eaiaeeoue
aei ?iceaaeo i?ioean?a aaoiiaoecio, caoaeeeaino?, i?ia?aeiino?
?iioeuen?a, nei?ioeeaino? i?iea?aeo.

Aeei?enoaiiy no/anieo i?ioea?eoi?/ieo cania?a aaco?oueny ia ?aea?
ii?iae?caoe?? o?ainii?oo ?ii?a oa i?ioean?a caoaeaeaiiy ? i?iaaaeaiiy
?iioeuen?a a ??cieo a?aeae?eao na?oey. Iaeiae oea ieoaiiy aea/aii ua
iaaeinoaoiuei. A oiio i?aea?? i?aia?ao?a aeey e?eoaaiiy eiie?aoiiai
aeaeo a?eoi?? a?oioo?oueny a iniiaiiio ia aii??e/iiio i?aeoiae?,
i?iaiaeeoueny /anoi aac a?aooaaiiy ia?oii?e/ei ?icaeoeo a?eoi??.

A?aeii? i?ioea?eoi?/i? caniae aeineoue /anoi aoaathoue iaeiaoaeoeaieie,
oiio ui ?o ae?y ia iaeiaeiaa i?e ??cieo aeaeao a?eoi?e. Aieea
aioea?eoi?e?a ia i?iea?ae ? i?aai?ci a oe?eiio ia caaaeaee iiceoeaiee.
A?eueo?noue c ieo i?iyaeythoue iaaaoeaio ?iio?iiio ae?th. ?o
aeei?enoaiiy /anoi noi?iaiaeaeo?oueny ?icaeoeii oaeeo aaaeeeo
oneeaaeiaiue, ye ii?ooaiiy i?ia?aeiino? ? iaa?oue iiyaith iiaii?
ao??iaaio?eeoey?ii? aeieaaee, ?icaeoeii na?oeaai? iaaeinoaoiino? aenieeo
a?aaeaoe?e (T. Matsumoto et al., 1993; T. Nawada et al., 1994; Y. Kihara
et al., 1996).

Aaeeaaiiy a?eueoino? i?ioea?eoi?/ieo cania?a iaiaaeaia /a?ac iayai?noue
i?ioeiieacaiue ? aaeeeo e?euee?noue iia?/ieo aoaeo?a (TH.A. Aioaeaae/ oa
ni?aaao., 1982; N.A. Iiiia oa ni?aaao., 1990; S. Dhein et al., 1993;
A.E. Aeaienthe oa ni?aaao., 1997), ye? iiaeooue iiai?noueth ciaoe?ieoe
iniiaio ae?th i?aia?aoo aai i?eaanoe aei iaiiaeeeaino? eiai
aeei?enoaiiy.

A?aoiaoth/e iacaaia aeua, iiooe iiaeo aenieiaoaeoeaieo i?ioea?eoi?/ieo
i?aia?ao?a caeeoa?oueny aeooaeueiei. Ia iao iiaeyae, i?ioea?eoi?/iee
can?a iiaeiai i?iyaeyoe iiceoeaio iie?o?iiio ae?th, oiaoi ia o?eueee
aieeaaoe ia i?ioeane caoaeaeaiiy ? i?ia?aeiino? a na?oe?, aea e
iie?auoaaoe ei?iia?iee ? iiceiaee e?iaiia?a, i?iyaeyoe aioea?iiene/io ?
naaeaoeaio aeanoeaino?, aooe iaeioiene/iei, ia aieeaaoe ia nenoaio
cn?aeaiiy e?ia?.

Iiooe iiaeo i?ioea?eoi?/ieo cania?a aaaeaoueny na?aae ??cieo eean?a
o?i?/ieo ?a/iaei: iio?aeieo aaicioo?aio, oaiio?aceio, aeeaaiciacai?io,
?iaeieo oa ?ioeo. (A.A. Noi?iaeoe, 1980; I.A. Aaeaiei-ss?ioaaneee oa
ni?aaao., 1984; I.A. Eaaa?eia, A.I. Neieaeeiia, 1984; C.I. Naiiaa oa
ni?aaao., 1984; A.A. Noiey?/oe, 1988; A.A. Ninoiia oa ni?aaao., 1990).
Ciaeaeai? niieoee c i?ioea?eoi?/iith aeoeai?noueth ? na?aae iio?aeieo
aeeaaici[d,f][1,3]ae?acai?io (O.E. Eunay, 1985). Iaeiae a ee?i?/io
i?aeoeeo i? iaeia c ieo ia aoea aaaaeaia /a?ac a?aenooi?noue ia?aaaa
ia?aae a?aeiieie i?aia?aoaie.

A i?aaenoaaeai?e ?iaio? i?eaiaeyoueny ?acoeueoaoe aeine?aeaeaiiy ia
aenia?eiaioaeueieo iiaeaeyo a?eoi?e 20 iiaeo iio?aeieo
2,2-ae?ai?iiaeeoai?eo oa aeeaaici[d,f][1,3]ae?acai?io. A aeinooii?e
e?oa?aoo?? ?ioi?iaoe?y i?i i?ioea?eoi?/io aeoeai?noue aeaieo niieoe ia
ciaeaeaia.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeeiiaia
aeena?oaoe?y ? /anoeiith ieaiiai? iaoeiai? ?iaioe eaoaae?e oa?iaeieia??
A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?. Ie?iaiaa ca
1994-98 ?iee ii oai? “Iiooe a?ieia?/ii aeoeaieo niieoe na?aae i?iaeoeo?a
o?i?/iiai neioaco oa iiaeeaeaia aea/aiiy oai?eaaa?aio oa aaicioo?iea?io”
(Aea?aeaaiee ?a?no?aoe?eiee ? 019V015832).

Iaoa ? caaea/? aeine?aeaeaiiy. Aeyaeoe na?aae aeine?aeaeoaaieo
iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io niieoeo c aenieith
i?ioea?eoi?/iith aeoeai?noueth, yeo iiaeia aoei a ?aeiiaiaeoaaoe aeey
noai?aiiy e?ea?nueei? oi?ie ? anaa?/iiai aea/aiiy a yeino? iioaioe?eiiai
i?ioea?eoi?/iiai caniao.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/?:

1. A aeine?aeao ia ieoao aecia/eoe aino?o oiene/i?noue 20 iiaeo
iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io.

2. Ia iiaeae? aeii?oeiiai? a?eoi?? aecia/eoe ?o i?ioea?eoi?/io
aeoeai?noue, aeyaeoe iaea?eueo aeoeaio niieoeo.

3. Aeine?aeeoe ?? i?ioea?eoi?/i? aeanoeaino? ia ??cieo iiaeaeyo
a?eoi?e: aeii?oeiia?e (c aeei?enoaiiyi ??cieo aeic),
oei?eaeeaeueoe??a?e, oei?eaeaa???a?e, no?ioaioeiia?e ? iino?oai?/i?e
?aia?ooc?ei?e. Ni?anoaaeoe aeoeai?noue aeaii? niieoee i?e eiaeiiio aeae?
a?eoi?e c ae??th a?aeiieo i?ioea?eoi?/ieo i?aia?ao?a.

4. Anoaiiaeoe aieea oe??? niieoee ia aeaeo?io?c?ieia?/i? iieacieee
?iaioe na?oey ? ii??a o?a?eeyoe?? oeoii/e?a.

5. Aea/eoe ?io? oa?iaeieia?/i? aeanoeaino? iaea?eueo aeoeaii? niieoee,
iniaeeai o?, iayai?noue yeeo ? aaaeaieie aeey i?ioea?eoi?/iiai caniao:
aioea?iiene/io ae?th, aieea ia iiceiaee oa ei?iia?iee e?iaiia?a, nenoaio
cn?aeaiiy e?ia?, i?noeaaiaianoacoth/o oa i?ioenoaeiiio aeoeai?noue.

6. A oiiaao noao?ii?/iiai aenia?eiaioo aecia/eoe ia?aiinei?noue ??cieo
aeic niieoee i?e ?? o?eaaeiio aaaaeaii? (1 i?nyoeue): aieea ia ciai?oi?e
aeaeyae, iiaaae?ieo oaa?ei, nia?oi?noue, ooieoe?iiaeueiee noai OeIN,
ia?eoa??eio e?ia, ie?ee, ia/?ieo ? ii?oieia?/io no?oeoo?o aioo??oi?o
i?aai?a. Iaoiaeii aiae?co o?iiiniiieo aaa?aoe?e aeine?aeeoe iooaaaiio
aeoeai?noue aeaii? niieoee.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. A ?iaio? i?aaenoaaeai?
?acoeueoaoe aeine?aeaeaiiy i?ioea?eoi?/ii? aeoeaiino? 20 i?ea?iaeueieo
niieoe ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io, ye? ?ai?oa a yeino?
i?ioea?eoi?/ieo cania?a ia aea/aeenue.

Caaaeyee i?iaaaeaiei aeine?aeaeaiiyi aia?oa aeyaeaia iiaa, aein?
iaa?aeiia a?oia o?i?/ieo niieoe, ye?e i?eoaiaii? i?ioea?eoi?/i?
aeanoeaino?. Na?aae iio?aeieo oe??? a?oie aeyaeaii niieoeo c
eaai?aoi?iei oeo?ii AIE-68 (2,2-ae?ai?iiaeeoai?e aeea?ae?ioei?eae), yea
nai?th aeoeai?noueth a aenia?eiaioao ia oaa?eiao ia?aaaaea? ae?th
a?aeiieo i?ioea?eoi?/ieo cania?a (ei?aea?iio, e?aeiea?io,
iiaiea?iai?aeo) ia aeii?oeiia?e ? oei?eaeaa???a?e iiaeaeyo a?eoi?? ?
i?e??aith?oueny aei ieo ia ?ioeo iiaeaeyo a?eoi?e.

O AIE-68 aeyaeai? oae? oe?ii? aeey aioea?eoi?ea aeanoeaino? ye
aioea?iiene/ia, caeaoi?noue iie?auoaaoe iiceiaee e?iaiia?a,
i?noeaaiaianoacoth/a, i?ioenoaeiiia ae??. Niieoea aeineoue aeia?a
ia?aiineoueny uo?aie i?e noao?ii?/iiio aaaaeaii?. Aiia ia i?iyaey?
iooaaaiii? ae?? ia ee?oeie e?noeiaiai iiceo ieoae.

I?ei?eoaoi?noue ?iaioe i?aeoaa?aeaeaia iaoaioii Oe?a?ie ? 22175 A, IEE
6 NI7D243/04.

Oai?aoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Oai?aoe/ia cia/aiiy
io?eiaieo ?acoeueoao?a iieyaa? a oiio, ui aia?oa aoaiiaeai? oe?ii?
oa?iaeieia?/i? aeanoeaino? 2,2-ae?ai?iiaeeoai?e?a. I?iaaaeai?
aeine?aeaeaiiy a?aee?eee 2,2-ae?ai?iiaeeoai?ee ye iiao a?oio niieoe,
caeaoieo i?iyaeyoe neeueio i?ioea?eoi?/io ae?th, aecia/eee ?o
oiene/i?noue ? aeaye? ?io? iiceoeai? oa?iaeieia?/i? aeanoeaino?.

O 2,2-ae?ai?iiaeeoai?e?a aia?oa aeyaeai? aioea?iiene/ia, i?ioenoaeiiia
ae?y, iiceoeaiee aieea ia iiceiaee e?iaiia?a, i?aeoaa?aeaia
i?noeaaiaianoacoth/a ae?y.

Aeine?aeaeaiiy aeaee ciiao anoaiiaeoe caeaaei?noue aeoeaiino? a?ae
o?i?/ii? no?oeoo?e niieoe, aena?oeeee aieea ai?ii?a ia ?o i?ioea?eoi?/io
aeoeai?noue, ui iiaea aooe aeei?enoaii o?i?eaie i?e iiaeaeueoiio neioac?
niieoe oe??? a?oie c iaoith iiaeaeueoiai oe?eani?yiiaaiiai iiooeo
a?ieia?/ii aeoeaieo ?a/iaei.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. A ?acoeueoao? i?iaaaeaieo
aeine?aeaeaiue aeyaeaia niieoea c eaai?aoi?iei oeo?ii AIE-68 c aenieith
i?ioea?eoi?/iith aeoeai?noueth, yea ia?aaa?oo? ae?th a?aeiieo
i?ioea?eoi?/ieo i?aia?ao?a ei?aea?iio, e?aeiea?io, iiaiea?iai?aeo.
Niieoea i?iyaey? ?io? oe?ii? aeanoeaino?, iaeioiene/ia, a oiiaii
oa?aiaaoe/ieo aeicao aeia?a ia?aiineoueny oaa?eiaie, ia i?iyaey?
iooaaaiii? aeoeaiino? ia ee?oeiao e?noeiaiai iiceo ieoae.

Io?eiai? aeai? aeathoue iiaeeea?noue ?aeiiaiaeoaaoe o?i?eai ?ic?iaeoe
iaoiae ? oiiae caaiaenueeiai neioaco niieoee, a oa?io?i?eai noai?eoe
e?ea?nueeo oi?io AIE-68 c iaoith anaa?/iiai aeine?aeaeaiiy ?? a yeino?
iioaioe?eiiai i?ioea?eoi?/iiai caniao a?o/eciyiiai iioiaeaeaiiy.

Ai?iaaaeaeaiiy a i?aeoeeo. Iaoa??aee aeine?aeaeaiiy ai?iaaaeaeaii a
eaeoe?eiee eo?n ii oa?iaeieia?? a oaiao “I?ioea?eoi?/i? oa
i?noeaaiaianoacoth/? caniae” a A?iieoeueeiio ? Eoaaineiio aea?aeaaieo
iaaee/ieo oi?aa?neoaoao, Aei?i?iiao?ianuee?e ? Oa?iii?euenuee?e
iaaee/ieo aeaaeai?yo.

Iniaenoee aianie caeiaoaa/a a iaea?aeaiiy iaoeiaeo ?acoeueoao?a, ui
aeiinyoueny ia caoeno

Aeena?oaoe?eia ?iaioa ? naiino?eiei iaoeiaei aeine?aeaeaiiyi aaoi?a.
Caeiaoaa/ai iniaenoi i?iaaaeaii ?ioi?iaoe?eiee iiooe, aecia/aiiy aino?i?
oiene/iino? niieoe, aeine?aeaeaiiy i?ioea?eoi?/ii? aeoeaiino? ia
aeii?oeiia?e, oei?eaeaa???a?e, oei?eaeeaeueoe??a?e, no?ioaioeiia?e,
iino?oai?/i?e ?aia?ooc?ei?e iiaeaeyo a?eoi?e, aea/aiiy
i?ioeo?a?eeyoi?ii?, i?noeaaiaianoacoth/i?, i?ioenoaeiiii?,
aioea?iiene/ii? ae??, aieeao ia ei?iia?iee ? iiceiaee e?iaiia?a,
noaoenoe/ia ia?iaea aeaiieo, ioi?ieaiiy aeena?oaoe?eii? ?iaioe ?
aaoi?aoa?aoo.

Aiae?c a?noieia?/ieo i?aia?ao?a i?iaaaeaii i?e eiinoeueoaoe?? i?io.
A.A. A?eo?i??iaa,  aiae?c iooaaaiii? aeoeaiino? – i?e eiinoeueoaoe??
e.i.i. E.A. Ee?ian, ca ui aaoi? aeneiaeth? ?i aeeaieo iiaeyeo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ia:

-Ia?oiio iaoe?iiaeueiiio c’?cae? oa?iaeieia?a Oe?a?ie “No/ani? i?iaeaie
oa?iaeieia??” (i. Iieoaaa, 27-29 aa?aniy 1995 ?.);

-II Iaoeiai-i?aeoe/i?e eiioa?aioe?? e?ea??a oa?eoi??aeueiiai iaaee/iiai
ia’?aeiaiiy i?nueei? ee?i?/ii? e?ea?i? N4 (i. A?iieoey, 15-16 o?aaiy
1995 ?.);

-II Oe?a?inuee?e iaoeia?e eiioa?aioe?? c i?aeia?iaeiith o/anoth
“Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??” (A?iieoey, 6-8 aeiaoiy 1998
?.)

– Iaoeiai-i?aeoe/i?e eiioa?aioe?? eaoaae?e i?iiaaeaaoeee aioo??oi?o
oai?ia “Aeooaeuei? i?iaeaie oa?ai??” (A?iieoey, 24-25 ethoiai 1999 ?.).

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 9 iaoeiaeo ?ia?o, c ieo
3 aac ni?aaaoi??a. Na?aae ieo 3 noaoo? a i?ia?aeieo iaoeiaeo aeo?iaeao,
5 ?ia?o a iaoa??aeao ? oacao eiioa?aioe?e, a oiio /ene? c i?aeia?iaeiith
o/anoth, io?eiaii 1 iaoaio Oe?a?ie.

No?oeoo?a oa ia?i aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia
145 noi??ieao iaoeiiieniiai oaenoo ? neeaaeathoueny c anooio, iaeyaeo
e?oa?aoo?e, ?icae?eo “Iaoa??aee ? iaoiaee aeine?aeaeaiiy”, 4 aeaa
aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, nieneo aeei?enoaii?
e?oa?aoo?e, ui i?noeoue 237 aeaea?ae, na?aae yeeo 101 a?o/eciyieo oa 136
?iicaiieo aaoi??a. Aeena?oaoe?y ?ethno?iaaia 9 oaaeeoeyie ? 19
iaethieaie.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Iaoa??aeii aeine?aeaeaiiy aoee 20
iiaeo niieoe – iio?aeieo ae?ai?iiaeeoai?eo ? aeeaaiciae?acai?io.
Niieoee i?aaenoaaeythoue niaith ??ci? nie? 2,2-ae?ai?iiaeeoai?eo oa
aeeaaicd,f1,3ae?acai?io. An? niieoee neioaciaai? o?i?eaie Aeiiaoeueeiai
oi?aa?neoaoo i?ae ea??aieoeoaii aeioeaioa A.I. Ia?oooie. Aeine?aeaeaiiy
?o aeoeaiino? i?iaaaeaii ia 558 ieoao, 413 uo?ao, 28 ii?nueeeo
naeieao, 59 e?oeao, 12 e?ieyo (anueiai 1070 oaa?ei) c aeei?enoaiiyi
caaaeueiii?eeiyoeo a oa?iaeieia?? iaoiae?a.

Aino?o oiene/i?noue an?o niieoe aea/aee ia a?eeo ieoao i?e
aioo??oiueii/a?aaeiiiio aaaaeaii?, a oiene/i?noue AIE-68 aecia/aee
oaeiae ia a?eeo uo?ao i?e aioo??oiueiaaiiiio aaaaeaii?. Ia?aiao?e
aino?i? oiene/iino? aecia/aee iaoiaeii E?/o?eueaea-O?eeieniia.

Ne?ei?iaia? aeine?aeaeaiiy i?ioea?eoi?/ii? aeoeaiino? i?iaiaeeee ia
a?eeo uo?ao c aeei?enoaiiyi aeii?oeiiai? iiaeae? a?eoi??. ??ciiieaiiaa
aea/aiiy i?ioea?eoi?/ieo aeanoeainoae iaea?eueo aeoeaii? niieoee
AIE-68 i?iaiaeeee ca?aeii ?aeiiaiaeiaaieo Oa?ieii?oaoii IIC Oe?a?ie
aeii?oeiiai?, oei?eaeeaeueoe??ai?, oei?eaeaa???ai?, no?ioaioeiiai?
iiaeaeae a?eoi?e, a i?ioeo?a?eeyoi?io ae?th aea/aee ia iiaeae?
iino?oai?/ii? ?aia?ooc?eii? o?a?eeyoe?? ia eioao ? oeyoii aecia/aiiy
ii?iao o?a?eeyoe?? oeoii/e?a ye ?ioaeoiiai i?iea?aeo uo??a, oae ? ia
oii? ?caae?eiiaiai o?aaeaiiy.

Aioea?iiene/io ae?th niieoee aea/aee a oiiaao aino?i? a?iien??, yeo
aeeeeeaee ia?aoeneaiiyi o?aoa? o a?eeo uo??a. Ca aeiiiiiaith AEA
?a?no?oaaee o?eaae?noue nei?i/aiue na?oey oaa?ei eiio?ieueii? ?
aeine?aeii? a?oie. Inoaii?i aei ia?aoeneaiiy o?aoa? i?aeoe??ii aaiaeeee
niieoeo AIE-68 a aeic? 20 ia/ea.

Aieea AIE-68 ia iiceiaee e?iaiia?a aeine?aeaeoaaee ia ia?eioeciaaieo
a?eeo uo?ao iaoiaeii ia?aa’ycee iaio niiieo a?oa??e c ianooiiith ?o
ia?a??ceith. *a?ac aeiao a?aoiaoaaee e?euee?noue aeaeeaoeo oaa?ei a
eiio?ieuei?e a?oi? ? a a?oi?, aea iiia?aaeiuei i?aeoe??ii aaiaeeee
AIE-68.

I?noeaaiaianoacoth/o ae?th AIE-68 aea/aee ia ii?nueeeo naeieao iaoiaeii
Atheuea?eia-Oaeaea.

I?ioenoaeiiio ae?th AIE-68 aecia/aee ia ieoao ca iaoiaeii iaeneiaeueiiai
aeaeo?inoaeiiiiai oieo.

I?e an?o ia?a?aoiaaieo aeine?aeaeaiiyo aeoeai?noue AIE-68
ii??aithaaee c ae??th a?aeiieo e?ea?nueeeo cania?a.

Aieea niieoee AIE-68 ia aeaeo?io?c?ieia?/i? iieacieee ?iaioe na?oey
aea/aee ia e?oeao, aecia/ath/e ii AEA:

– /anoioo nei?i/aiue na?oey;

– o?eaae?noue ?ioa?aaeo PQ;

– o?eaae?noue aeaeo?e/ii? nenoiee na?oey (?ioa?aaeo QT);

– /an a?aeiiaeaiiy ooieoe?? neioniaiai aocea;

– i?ia?aei?noue ao??iaaio?eeoey?iiai aocea oeyoii aecia/aiiy aioa- ?
?ao?ia?aaeii? oi/ee Aaieaaaoa.

Aieea AIE-68 ia ia’?iio oaeaee?noue ei?iia?iiai e?iaioieo oa
a?oa??aeueiee oene aea/aee ia e?oeao ca iaoiaeii I.A. Eaaa??ii?.

Ae?th AIE-68 ia iieacieee nenoaie cai?oaiiy e?ia? ioe?ithaaee ia a?eeo
uo?ao caaaeueiii?eeiyoeie a ee?ieoe? iaoiaeaie.

Noao?ii?/io oiene/i?noue ? nooi?iue aacia/iino? o?eaaeiai aaaaeaiiy
AIE-68 aea/aee ia a?eeo uo?ao i?e aioo??oiueii/a?aaeiiiio aaaaeaii?
niieoee ia i?ioyc? 1 i?nyoey. Ci?ie a noai? oaa?ei i?ae aieeaii ??cieo
aeic niieoee a ii??aiyii? c eiio?ieai aecia/aee ii noai?,
?aeiiaiaeiaai?e Oa?ieii?oaoii, ? ca aeiiiiiaith ai?iaiaaieo
o?c?ieia?/ieo, a?io?i?/ieo, a?noieia?/ieo iaoiae?a.

Aeey aecia/aiiy iooaaaiii? aeoeaiino? AIE-68 aeei?enoiaoaaee iaoiae
iaoaoaciiai aiae?co ee?oei e?noeiaiai iiceo ieoae.

?acoeueoaoe aeine?ae?a aoei i?aeaeaii noaoenoe/iiio aiae?co c
aeei?enoaiiyi e?eoa??th Nothaeaioa A aeiaaeeao c aeueoa?iaoeaiei
aa??thaaiiyi iciae aeei?enoiaoaaee oi?ioee aeey a?iii?aeueiiai
?iciiae?eaiiy, ioeueiaee (100%) aoaeo ioe?ithaaee ca aeiiiiiaith oi?ioee
aai aea? Aa?aeaia oa oi/iiai e?eoa??th O?oa?a. EAe50 ? AAe50 niieoe
aecia/aee iaoiaeii E?/o?eueaea-O?eeieniia. I?ioea?eoi?/iee ?
i?ioenoaeiiiee ?iaeaene aecia/aee ye a?aeiioaiiy EAe50 aei AAe50.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. Aino?a oiene/i?noue
niieoe a aeine?aeao ia ieoao eieeaaeanue a?ae 290 aei 428 ia/ea.
Oiene/i?noue iaea?eueo aeoeaii? niieoee AIE-68 ia ieoao i?e
aioo??oiueii/a?aaeiiiio aaaaeaii? neeaea 377,0 296,6:478,8 ia/ea, ia
uo?ao i?e aioo??oiueiaaiiiio aaaaeaii? 120,0 100,0:144,0 ia/ea.

A eiio?ieueieo aeine?aeao aeii?oei a aeic? 30 iea/ea a 10 aeine?aeao c
10 (100,07,65%) aeeeeeaa /a?ac 1-4 oaeeeie i?ney aioo??oiueiaaiiiai
aaaaeaiiy ?icaeoie a?eoi??, yea o?eaaea aei 1 aiaeeie. Aiia i?iyaeyeanue
/anoith iie?oiiiith a?oiiaith oeoii/eiaith ? iaaeoeoii/eiaith
aeno?anenoie??th, ia?aoo?iiyi ia?aaena?aeue ? oeoii/e?a. A a?eueoino?
aeiaaee?a a?eoi?y cae?i/oaaeanue nia?oth oaa?ei.

Ia aeii?oeiia?e iiaeae? a?eoi?? i?iaaaeaii ne?ei?iaiaa aeine?aeaeaiiy
i?ioea?eoi?/ii? aeoeaiino? an?o 20 niieoe. ?o aaiaeeee a aeicao, ui
neeaaeathoue 5% a?ae EAe50. Aeoeai?noue niieoe ? o?eaae?noue ?o ae??
i?aaenoaaeaia a oaae. 1.

Oaaeeoey 1

I?ioea?eoi?/ia aeoeai?noue iio?aeieo ae?ai?iiaeeoai?eo oa
aeeaaiciae?acai?io ia aeii?oeiia?e iiaeae? a?eoi?? o uo??a, Im

Oeo? niieoeeAeica, ia/eaE?euee?noue

aeine?ae?a*anoioa a?aeiiaeaiiy neioniaiai ?eoioO?eaae?noue a?aeiia-eaiiy
neioniaiai ?eoio,
oaaaniethoia%AIE-69207685,713,23*5,42,19AIE-352077100,09,93*1,90,32AIE-6
8191010100,07,65*34,08,12AIE-301877100,09,93*13,76,24AI-65167685,713,23*
12,66,41AIE-27157685,713,23*7,91,82AO-13207457,118,71*1,00,39AIE-3215771
00,09,93*11,12,92AO-141877100,09,93*15,45,65AI-661677100,09,93*3,41,06AI
E-921577100,09,93*8,32,94AIE-64155480,017,89*0,90,24AAA-11205240,021,910
,30,2AAA-817500,012,370AIE-107155240,021,910,40,29AIE-76205240,021,910,3
0,15AIE-63185120,017,890,10,1AAE128205120,017,890,20,2AAA-6515500,012,37
0AA-4819500,012,370I?ei?oea: ciaeii * iicia/aia aeinoia??ia ??cieoey c
eiio?ieai (P0,05).

C 20 aeine?aeaeoaaieo niieoe 12 i?iyaeee caeaoi?noue eoi??oaaoe
aeii?oeiiao a?eoi?th. Na?aae ieo a?eueoo aeoeai?noue i?iyaeee niieoee
AIE-68, AIE-35, AIE-30, AIE-32, AO-14, AI-66, AIE-92. Aiie eoi??oaaee
a?eoi?th a 100% aeine?ae?a. Aeaui iaioee aoaeo i?iyaeyee niieoee AIE-69,
AI-65, AIE-27, AO-13 ? AIE-64. Aiie eoi??oaaee a?eoi?th a 57-85%
aeine?ae?a. An? aeua ia?a?aoiaai? niieoee ? ??cieie nieyie
2,2-ae?ai?iiaeeoai?eo. Na?aae ieo ii o?eaaeino? ae?? iaea?eueo aeoeaiith
aeyaeeanue niieoea AIE-68. ?? i?ioea?eoi?/iee aoaeo i?iaeiaaeoaaany a
na?aaeiueiio 34,08,12 oa. O?eaae?noue ae?? ?ioeo niieoe aoea cia/ii
iaiueoith. Iio?aeia 2,2-ae?ai?iiae?oai?eo i?ae eaai?aoi?iei oeo?ii
AAA-11 ? an? aeine?aeaeoaai? niieoee aeeaaiciae?acai?io i?iyaeyee
noaoenoe/ii iacia/eiee aoaeo.

Iaea?eueo aeoeaia niieoea AIE-68 aoea aeine?aeaeaia ia aeii?oeiia?e
iiaeae? a?eoi?? a ??cieo aeicao: 9,5; 4,7 ? 1 ia/ea. Aiie noaiiaeyoue
i?eaeecii 8, 4 ? 1% EAe50 aeey uo??a. Aeyaeeinue, ui iaa?oue a aeic? 1
ia/ea AIE-68 a 100% aeine?ae?a ei?ioei/anii eoi??oaaea aeii?oeiiao
a?eoi?th (oaae. 2). O an?o aeiaaeeao aoaeo ?icaeaaany a e?ioe?
aioo??oiueiaaiiiai aaaaeaiiy niieoee aai ia ia?o?e oaeeei? i?ney ??
aaaaeaiiy. O?eaae?noue ae?? AIE-68 aoea i?yii i?iii?oe?eia aeic? ?
ci?ithaaeanue a?ae 1-5 oaeeei i?e aeic? 1 ia/ea aei 90 oaeeei i?e aeic?
19 ia/ea. I?e aaaaeaii? aeice 9,5 ia/ea aoaeo o?eaaa a na?aaeiueiio
15,74,14 oa.

Oaaeeoey 2

I?ioea?eoi?/ia aeoeai?noue AIE-68, ei?aea?iio, e?aeiea?io oa
iiaiea?iai?aeo ia aeiieoeiia?e iiaeae? a?eoi?? o uo??a, Im

Oeo? niieoeeAeica, ia/eaE?euee?noue aeine?ae?a*anoioa a?aeiiaeaiiy
neioniaiai ?eoioO?eaae?noue a?aeiiaeaiiy neioniaiai ?eoio,
oaaaniethoia%AIE-68191010100,07,65*34,08,12*9,51010100,07,65*15,74,14*4,
71010100,07,65*5,40,73*11010100,07,65*2,10,51Ei?aea?ii1010330,012,711,00
,56E?aeiea?i1010330,012,710,90,48Iiaiea?iai?ae2010440,013,581,70,84
I?ei?oea: ciaeii * iicia/aia aeinoia??ia ??cieoey c ei?aea?iiii,
e?aeiea?iii, iiaiea?iai?aeii (P0,01).

Na?aaeiy aoaeoeaia aeica (AAe50) AIE-68, yea ii?iae?coaaea ii?ooaiee
aeii?oeiii ?eoi na?oey ia ia??iae a?eueoa 5 oa, aei??aithaaea 2,5
[0,966,50] ia/ea, ui noaiiaeoue 2% a?ae EAe50 niieoee aeey uo??a.
I?ioea?eoi?/iee ?iaeaen AIE-68 aei??aith? 48.

Ii i?ioea?eoi?/i?e aeoeaiino? ia aeii?oeiia?e iiaeae? a?eoi?? AIE-68
ia?aaa?ooaaea ae?th ei?aea?iio ? e?aeiea?io (10 ia/ea), ye? o 3
aeiaaeeao ?c 10, oa iiaiea?iai?aeo (20 ia/ea), yeee o 4 aeiaaeeao ?c 10,
o?eueee ei?ioei/anii a?aeiiaethaaee ii?ooaiee aeii?oeiii ?eoi na?oey.

A aeine?aeao c iiia?aaeaeaiiyi aeieeiaiiy aeii?oeiiai? a?eoi??
anoaiiaeaii, ui AIE-68 a aeic? 19 ia/ea, aaaaeaia ca 2-5 oaeeei aei
aeii?oeio cao?eio? ?icaeoie aeii?oeiiai? a?eoi?? a na?aaeiueiio ia 10
oaeeei, oiae? ye a eiio?ieueieo aeine?aeao aeii?oeiiaa a?eoi?y
?icaeaaeanue ia 1 – 4 oaeeei?. Ca?eueoaiiy aeice niieoee aei 40 ia/ea
a?aeaeaeyei ?icaeoie a?eoi?? a na?aaeiueiio ia 22 oaeeeie, i?e oeueiio a
2 aeiaaeeao c 5 a?eoi?y acaaae? ia aeieeea.

Oaeei /eiii, AIE-68 ia aeii?oeiia?e iiaeae? a?eoi?? i?iyaey? neeueiee,
noaa?eueiee ? aeineoue o?eaaeee i?ioea?eoi?/iee aoaeo. Ii aeoeaiino? ?
o?eaaeino? ae?? aiia cia/ii ia?aaa?oo? a?aeii? i?ioea?eoi?/i? caniae
ei?aea?ii, e?aeiea?i ? iiaiea?iai?ae. Niieoea caeaoia ia o?eueee
eoi??oaaoe aeii?oeiiao a?eoi?th, a ? a?aeaeaeyoe /an ?? aeieeiaiiy.

Aeniea aeoeai?noue AIE-68 ia aeii?oeiia?e iiaeae? a?eoi?? niiioeaea aei
aea/aiiy ?? aeoeaiino? ia ?ioeo iiaeaeyo a?eoi?e ? aeine?aeaeaiiy
ae?oaeo oa?iaeieia?/ieo aeanoeainoae.

A eiio?ieueieo aeine?aeao oaeaeea aioo??oiueiaaiia aaaaeaiiy uo?ai 10%
?ic/eio eaeueoe?th oei?eaeo a aeic? 2,2 ie/ea /a?ac 5-10 naeoiae a 10
aeine?aeao c 10 (100,07,65%) aeeeeeaei ?icaeoie a?eoi??, yea ia?aoiaeeea
a o?a?eeyoe?th oeoii/e?a ? a a?eueoino? aeine?ae?a cae?i/oaaeanue
caaeaaeth oaa?ei ia i?ioyc? 1 oaeeeie.

I?io?eaeoe/ia aioo??oiueiaaiia aaaaeaiiy niieoee AIE-68 a aeic? 30
ia/ea iiia?aaeaeaei ?icaeoie a?eoi?? a 5 aeiaaeeao ?c 7 (a 71,414,3%). A
aeic? 20 ia/ea iiae?aiee aoaeo aoa aeyaeaiee eeoa a 2 aeiaaeeao c 8
(25,013,05%), a a aeic? 10 ia/ea a 1 aeine?ae? c 8 (12,59,97%).
Ei?aea?ii (10 ia/ea) iiia?aaeaeaa ?icaeoie a?eoi?? a 4 aeine?aeao c 10
(40,013,56%), a e?aeiea?i a 3 aeine?aeao c 10 (30,012,71%).

Io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui AIE-68 a aeicao 10 ? 20 ia/ea
iaei aieeaa? ia ?icaeoie oei?eaeeaeueoe??ai? a?eoi?? ? eeoa a aeic? 30
ia/ea i?iyaey? i?ioea?eoi?/iee aoaeo (P0,05). Aoaeoeai?noue i?aia?ao?a
ii??aiyiiy ei?aea?iio ? e?aeiea?io oaae aoea iacia/iith.

sse a?aeiii, oei?eaeaa???aa iiaeaeue ii?ooaiue na?oeaaiai ?eoio
i?iaiaeeoueny ia e?ieyo aac canoinoaaiiy ia?eico a oiiaao a?eueii?
iiaaae?iee oaa?eie, ui aea? iiaeeea?noue aeeeth/eoe aieea ia?eico ia
i?iea?ae. A oiae? aeine?ae?a oaa?eie, ye i?aaeei, caeeoathoueny aeeaeie,
?o /a?ac 7-10 aei?a iiaeia aeei?enoiaoaaoe aeey iiaoi?ieo
aeine?aeaeaiue.

Aioo??oiueiaaiii aaaaeaia e?ieyi niieoea AIE-68 a aeic? 10 ia/ea /a?ac
1-4 oaeeeie i?ney ?icaeoeo oei?eaeaa???ai? a?eoi?? a?aeiiaethaaea
ii/aoeiaee neioniaee ?eoi o an?o 7 oaa?ei, oiaoi a 100,09,93%
aeine?ae?a. Acyo? aeey ii??aiyiiy ei?aea?ii (5 ia/ea) ? e?aeiea?i (10
ia/ea) i?iyaeyee aoaeo a 6 aeine?aeao c 10 (60,013,59%).

Ioaea niieoea AIE-68 ia oei?eaeaa???a?e iiaeae? a?eoi?? i?iyaey?
i?ioea?eoi?/io ae?th, yea ia?aaa?oo? aeoeai?noue e?aeiea?io ? ei?aea?iio
(P0,05),

A eiio?ieueieo aeine?aeao No?ioaioei-E aeeeeeaa ?icaeoie a?eoi?? o
aeaeyae? iaaeoeoii/eiai? ? oeoii/eiai? aeno?anenoie??, ia?ieneciaeueii?
oeoii/eiai? oao?ea?ae??, yea i?iaeiaaeoaaeanue 13,03,63 oaeeei,
cae?i/oaaeanue iiyaith ?ae?iaaio?eeoey?iiai ?eoio ? caaeaaeth oaa?ei.
AIE-68 a aeic? 10 ia/ea a?aeiiaethaaea ii?ooaiee no?ioaioeiii ?eoi
na?oey ia 11,03,63 oaeeei o 4 aeiaaeeao ?c 7, oiaoi o 57,015,66%
aeine?ae?a (P0,05). Ae?y niieoee ?icaeaaeanue /a?ac 4-5 oaeeei i?ney
aaaaeaiiy. Caaaeii aieea AIE-68 ia no?ioaioeiiao a?eoi?th iiaeia
aecia/eoe ye iii??iee.

A eiio?ieueieo aeine?aeao ia iiaeae? iino?oai?/ii? ?aia?ooc?eii?
a?eoi?? ?aioiaa a?aeiiaeaiiy e?iaiia?ao a ?oai?ciaaiiio i?iea?ae? e?oie
aeeeeeaei ia i?ioyc? ia?oeo 5 oaeeei o?a?eeyoe?th oeoii/e?a na?oey a 8
aeiaaeeao c 10 (80,0±12,65%). Niieoea AIE-68, aaaaeaia ca 5 oaeeei aei
?icioneo e?aaoo?e a aeic? 10 ia/ea, iiia?aaeaeoaaea ?icaeoie o?a?eeyoe??
oeoii/e?a a 7 aeiaaeeao c 10, oiaoi a 70,012,71% aeine?ae?a. C ieo o 3
oaa?ei ?aia?ooc?y i?ioiaeeea aac ii?ooaiue ?eoio na?oey c iinooiiaei
cieeiaiiyi i?iya?a ?oai??, a a 4 aeine?aeao i?ney ?icioneo e?aaoo?e
?icaeaaeanue ei?ioei/ania a?eoi?y o aeaeyae? oeoii/eiai? aeno?anenoie??
? ia?ieneciaeueii? oeoii/eiai? oao?ea?ae??, aea o?a?eeyoe?y oeoii/e?a
i?e oeueiio ia aeieeaea. O iaei??? oaa?eie oeoii/eiaa aeno?anenoie?y ?
ia?ieneciaeueia oeoii/eiaa oao?ea?ae?y aeieeea i?ae /an ?oai?? ua aei
?icioneo e?aaoo?e ? aoea eoi??oaaia aaaaeaiiyi AIE-68. Ei?aea?ii (5
ia/ea) iiia?aaeaeaa ?icaeoie o?a?eeyoe?? oeoii/e?a a 3 aeiaaeeao c 6
(50,016,6%), a e?aeiea?i (10 ia/ea) a 3 aeiaaeeao c 5 (60,017,3%)
aeine?ae?a.

Oaeei /eiii, ia iiaeae? iino?oai?/ii? ?aia?ooc?eii? a?eoi?? AIE-68
i?iyaey? aeinoia??io i?ioea?eoi?/io ae?th (P0,05), yea i?e??aith?oueny
aei ae?? ei?aea?iio ? e?aeiea?io.

I?ae aieeaii AIE-68 (10 ia/ea) ca?eueooaaany (?0,05) ii??a o?a?eeyoe??
oeoii/e?a o ?ioaeoieo uo??a c 2,870,26 A aei 4,130,40 A (ca?eueoaiiy ia
43%), aea ae?y niieoee aoea ei?ioei/ania. Aaaaeaiiy AIE-68 (10 ia/ea) ia
oii? ?caae?eiiaiai o?aaeaiiy i?iea?aeo ca?eueooaaei (?0,01) cieaeaiee
?caae?eiii ii??a o?a?eeyoe?? oeoii/e?a c 1,900,15 aei 3,500,43 A
(ca?eueoaiiy ia 84%), ia ia?o?e oaeeei? i?ney aaaaeaiiy (oaae. 3). *a?ac
5 oaeeei i?ney aaaaeaiiy niieoee ii??a o?a?eeyoe?? oeoii/e?a
ca?eueooaaany (?0,01) aei 3,900,64 A (ca?eueoaiiy ia 105,3%), iaeiae
/a?ac 15 oaeeei i?aeaeuaiiy neeaaeaei eeoa 47,4%. Acyoee aeey
ii??aiyiiy e?aeiea?i a aeic? 10 ia/ea c?aco i?ney aaaaeaiiy i?aeaeuoaaa
(?0,001) cieaeaiee ?caae?eiii ii??a o?a?eeyoe?? oeoii/e?a c 2,930,37
aei 6,930,82 A (ia 136,5%), /a?ac 5 oaeeei ii??a ??aiyany 7,210,82 A
(i?aeaeuaiiy ia 146%), /a?ac 15 oaeeei ia – 6,430,92 A (ca?eueoaiiy ia
119,5%).

Oaaeeoey 3

Aieea AIE-68 ? e?aeiea?io ia ii??a o?a?eeyoe?? oeoii/e?a i?e
?caae?eiiaiio o?aaeaii? i?iea?aeo, Im

Iacaa

niieoee ?

aeicanIi??a o?a?eeyoe?? oeoii/e?a, Aaeo?aeiee /a?ac 15 oa i?ney aaaaeai-

iy ?caae?eio i?ney aaaaeaiiy niieoeeia 1 oaia 5 oaia 15 oaAIE-68,

10 ia/ea

10

3,550,321,900,15 ?0,001

-46,5%3,500,43

?0,01

+84,2%3,900,64

?0,01 +105,3%2,800,32

?0,05

+47,7%E?aeiea?i, 10 ia/ea

7

4,430,152,930,37

?0,02

-33,9%6,930,82

?0,001

+136,5%7,210,82

?0,001 +146,0%6,430,92

?0,01 +119,5%I?ei?oea: ciaeii + iicia/aii ca?eueoaiiy, ciaeii –
ciaioaiiy ii?iao o?a?eeyoe?? oeoii/e?a.

Oaeei /eiii, AIE-68 a aeic? 10 ia/ea i?aeaeuoaaa cieaeaiee ?caae?eiii
ii??a o?a?eeyoe?? oeoii/e?a (P0,01), aea ii aoaeoeaiino? iinooiaany
e?aeiea?io.

AIE-68 a aeic? 10 ia/ea aeinoia??ii (?0,05) ciaioo? /anoioo na?oeaaeo
nei?i/aiue (*NN) c ii/aoeiaeo 18813,15 aei 14310,28 (ia 23,9%) ?
ca?eueoo? (?0,05) /an a?aeiiaeaiiy ooieoe?? neioniaiai aocea (*AONA) c
0,380,024 aei 0,490,044 (ia 28,9%). I?ae aieeaii niieoee i?iyaeyeanue
oaiaeaioe?y aei ciaioaiiy i?ia?aeiino? ao??i-aaio??eoey?iiai aocea ia
12,8% ? ?ao?ia?aaeiiai i?iaaaeaiiy /a?ac ao??i-aaio?eeoey?iee aocie ia
20,9% (oaae. 4). Io?eiai? ?acoeueoaoe iiaeooue na?ae/eoe i?i
caeaoi?noue AIE-68 i?eai?/oaaoe neioniaee aocie. Oaea aeanoea?noue
niieoee iiaea aooe aeei?enoaia i?e e?eoaaii? neioniaeo a?eoi?e. A oie
aea /an i?e neiae?ii? neaaeino? neioniaiai aocea niieoeo iaiao?aeii
aeei?enoiaoaaoe c iaa?aaei?noth.

Oaaeeoey 4

Aieea AIE-68 (10 ia/ea) ia aeaeo?io?c?ieia?/i? iieacieee

?iaioe na?oey e?oie, Im

IieacieenAeo?aei? aeai?*a?ac 15 oa i?ney aaaaeaiiy AIE-68 ??cieoey
aeaieo a %*NN7188,0±13,15143,0±10,28* -23,9%?ioa?aae PQ,
n70,067±0,0030,074±0,008+ 10%?ioa?aae QT, n70,22±0,0080,27±0,024
+22,7%*AONA, n70,38±0,0240,49±0,044* +28,9%Oi/ea
Aaieaaaoa7334,0±13,91291,0±19,66 -12,8%?ao?ia?aaeia oi/ea
Aaieaaaoa5286,0±21,52246,6±30,47 -20,9% I?ei?oea: ciaeii – iicia/aii
ciaioaiiy iieacieea, ciaeii + ca?eueoaiiy, ciaeii * – aeinoia??ia
??cieoey c aeo?aeieie aeaieie (?

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