2

AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OA?IAEIEIA?? OA OIENEEIEIA??

Aeaieeue/oe ?ai? A?oae?eiae/

OAeE 615.22:547.553.2

IIOOE AOAEOEAIEO I?IOEA?EOI?*IEO CANIA?A

NA?AAe IIAEO IIO?AeIEO Ae?AI?IIAeEOAI?EO OA AeEAAICIAe?ACAI?IO

14.03.05 — oa?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a A?iieoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I.?. Ie?iaiaa IIC Oe?a?ie.

Iaoeiaee ea??aiee: caneoaeaiee ae?y/ aeui? oeiee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, Noiey?/oe Ieaenaiae? Ieaenaiae?iae/, A?iieoeueeee
aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.?. Ie?iaiaa IIC Oe?a?ie,
i?ioani? eaoaae?e oa?iaeieia??.

.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, O?aiae Aieiaeeie?
Aaiaaeeeoiae/, ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie,
aieiaiee iaoeiaee ni?a?ia?oiee;

aeieoi? iaaee/ieo iaoe, Ai?/aeiaa Iaae?y Ieaenaiae??aia, Iaoe?iiaeueiee
iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey, i?ioani? eaoaae?e
oa?iaeieia??.

I?ia?aeia onoaiiaa: Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
eaoaae?a caaaeueii? oa ee?i?/ii? oa?iaeieia??.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “__13__” aeiaoiy 1999 ?ieo i “15”
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.550.01 i?e
?inoeooo? oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, i.Ee?a,
aoe. A.Iiouea, 14)

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, i.Ee?a, aoe.
A.Iiouea, 14)

Aaoi?aoa?ao ?ic?neaiee “10”aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee, e.a.i.
?.A. Aeaiiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aeey e?eoaaiiy ii?ooaiue na?oeaaiai ?eoio a
ee?i?/i?e i?aeoeoe? ca?ac aeei?enoiao?oueny aeineoue aaeeea a?oia
i?ioea?eoi?/ieo cania?a, ye? a?aeiinyoueny aei ??cieo eean?a o?i?/ieo
niieoe (I.A. Eaaa?eia, 1994; I.A. Iaco?, 1994; I.N. Eooaeianeee, 1998;
I.Ae. Iaoeianeee, 1998).

Iaeiae, iacaaaeath/e ia oe?ieee aea?? aioea?eoi?e?a, i?iaeaia ai?ioueae
c a?eoi?yie nueiaiaei? ua ia ae??oaia.

A?eoi?y — oea eeoa neiioii, ui aeaco? ia ii?ooaiiy aeanoeainoae
i?iea?aeo. Oe? ii?ooaiiy iiaeooue ianooieoe a ?acoeueoao? caiaeueieo,
aeeno?io?/ieo, ?oai?/ieo, oiene/ieo a?aaeaiue i?iea?aeo, ?iceaaeo
ia?aiai? oa ai?iiiaeueii? ?aaoeyoe?? na?oeaai? ae?yeueiino? oa ?ioeo
i?e/ei. Iane?aeeii ae?? oeeo oaeoi??a ? ii?ooaiiy ii?iaeueiiai
o?ainii?oo ?ii?a a ee?oeiao i?ia?aeii? nenoaie na?oey, ui i?eaiaeeoue
aei ?iceaaeo i?ioean?a aaoiiaoecio, caoaeeeaino?, i?ia?aeiino?
?iioeuen?a, nei?ioeeaino? i?iea?aeo.

Aeei?enoaiiy no/anieo i?ioea?eoi?/ieo cania?a aaco?oueny ia ?aea?
ii?iae?caoe?? o?ainii?oo ?ii?a oa i?ioean?a caoaeaeaiiy ? i?iaaaeaiiy
?iioeuen?a a ??cieo a?aeae?eao na?oey. Iaeiae oea ieoaiiy aea/aii ua
iaaeinoaoiuei. A oiio i?aea?? i?aia?ao?a aeey e?eoaaiiy eiie?aoiiai
aeaeo a?eoi?? a?oioo?oueny a iniiaiiio ia aii??e/iiio i?aeoiae?,
i?iaiaeeoueny /anoi aac a?aooaaiiy ia?oii?e/ei ?icaeoeo a?eoi??.

A?aeii? i?ioea?eoi?/i? caniae aeineoue /anoi aoaathoue iaeiaoaeoeaieie,
oiio ui ?o ae?y ia iaeiaeiaa i?e ??cieo aeaeao a?eoi?e. Aieea
aioea?eoi?e?a ia i?iea?ae ? i?aai?ci a oe?eiio ia caaaeaee iiceoeaiee.
A?eueo?noue c ieo i?iyaeythoue iaaaoeaio ?iio?iiio ae?th. ?o
aeei?enoaiiy /anoi noi?iaiaeaeo?oueny ?icaeoeii oaeeo aaaeeeo
oneeaaeiaiue, ye ii?ooaiiy i?ia?aeiino? ? iaa?oue iiyaith iiaii?
ao??iaaio?eeoey?ii? aeieaaee, ?icaeoeii na?oeaai? iaaeinoaoiino? aenieeo
a?aaeaoe?e (T. Matsumoto et al., 1993; T. Nawada et al., 1994; Y. Kihara
et al., 1996).

Aaeeaaiiy a?eueoino? i?ioea?eoi?/ieo cania?a iaiaaeaia /a?ac iayai?noue
i?ioeiieacaiue ? aaeeeo e?euee?noue iia?/ieo aoaeo?a (TH.A. Aioaeaae/ oa
ni?aaao., 1982; N.A. Iiiia oa ni?aaao., 1990; S. Dhein et al., 1993;
A.E. Aeaienthe oa ni?aaao., 1997), ye? iiaeooue iiai?noueth ciaoe?ieoe
iniiaio ae?th i?aia?aoo aai i?eaanoe aei iaiiaeeeaino? eiai
aeei?enoaiiy.

A?aoiaoth/e iacaaia aeua, iiooe iiaeo aenieiaoaeoeaieo i?ioea?eoi?/ieo
i?aia?ao?a caeeoa?oueny aeooaeueiei. Ia iao iiaeyae, i?ioea?eoi?/iee
can?a iiaeiai i?iyaeyoe iiceoeaio iie?o?iiio ae?th, oiaoi ia o?eueee
aieeaaoe ia i?ioeane caoaeaeaiiy ? i?ia?aeiino? a na?oe?, aea e
iie?auoaaoe ei?iia?iee ? iiceiaee e?iaiia?a, i?iyaeyoe aioea?iiene/io ?
naaeaoeaio aeanoeaino?, aooe iaeioiene/iei, ia aieeaaoe ia nenoaio
cn?aeaiiy e?ia?.

Iiooe iiaeo i?ioea?eoi?/ieo cania?a aaaeaoueny na?aae ??cieo eean?a
o?i?/ieo ?a/iaei: iio?aeieo aaicioo?aio, oaiio?aceio, aeeaaiciacai?io,
?iaeieo oa ?ioeo. (A.A. Noi?iaeoe, 1980; I.A. Aaeaiei-ss?ioaaneee oa
ni?aaao., 1984; I.A. Eaaa?eia, A.I. Neieaeeiia, 1984; C.I. Naiiaa oa
ni?aaao., 1984; A.A. Noiey?/oe, 1988; A.A. Ninoiia oa ni?aaao., 1990).
Ciaeaeai? niieoee c i?ioea?eoi?/iith aeoeai?noueth ? na?aae iio?aeieo
aeeaaici[d,f][1,3]ae?acai?io (O.E. Eunay, 1985). Iaeiae a ee?i?/io
i?aeoeeo i? iaeia c ieo ia aoea aaaaeaia /a?ac a?aenooi?noue ia?aaaa
ia?aae a?aeiieie i?aia?aoaie.

A i?aaenoaaeai?e ?iaio? i?eaiaeyoueny ?acoeueoaoe aeine?aeaeaiiy ia
aenia?eiaioaeueieo iiaeaeyo a?eoi?e 20 iiaeo iio?aeieo
2,2-ae?ai?iiaeeoai?eo oa aeeaaici[d,f][1,3]ae?acai?io. A aeinooii?e
e?oa?aoo?? ?ioi?iaoe?y i?i i?ioea?eoi?/io aeoeai?noue aeaieo niieoe ia
ciaeaeaia.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeeiiaia
aeena?oaoe?y ? /anoeiith ieaiiai? iaoeiai? ?iaioe eaoaae?e oa?iaeieia??
A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?. Ie?iaiaa ca
1994-98 ?iee ii oai? «Iiooe a?ieia?/ii aeoeaieo niieoe na?aae i?iaeoeo?a
o?i?/iiai neioaco oa iiaeeaeaia aea/aiiy oai?eaaa?aio oa aaicioo?iea?io»
(Aea?aeaaiee ?a?no?aoe?eiee ? 019V015832).

Iaoa ? caaea/? aeine?aeaeaiiy. Aeyaeoe na?aae aeine?aeaeoaaieo
iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io niieoeo c aenieith
i?ioea?eoi?/iith aeoeai?noueth, yeo iiaeia aoei a ?aeiiaiaeoaaoe aeey
noai?aiiy e?ea?nueei? oi?ie ? anaa?/iiai aea/aiiy a yeino? iioaioe?eiiai
i?ioea?eoi?/iiai caniao.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/?:

1. A aeine?aeao ia ieoao aecia/eoe aino?o oiene/i?noue 20 iiaeo
iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io.

2. Ia iiaeae? aeii?oeiiai? a?eoi?? aecia/eoe ?o i?ioea?eoi?/io
aeoeai?noue, aeyaeoe iaea?eueo aeoeaio niieoeo.

3. Aeine?aeeoe ?? i?ioea?eoi?/i? aeanoeaino? ia ??cieo iiaeaeyo
a?eoi?e: aeii?oeiia?e (c aeei?enoaiiyi ??cieo aeic),
oei?eaeeaeueoe??a?e, oei?eaeaa???a?e, no?ioaioeiia?e ? iino?oai?/i?e
?aia?ooc?ei?e. Ni?anoaaeoe aeoeai?noue aeaii? niieoee i?e eiaeiiio aeae?
a?eoi?e c ae??th a?aeiieo i?ioea?eoi?/ieo i?aia?ao?a.

4. Anoaiiaeoe aieea oe??? niieoee ia aeaeo?io?c?ieia?/i? iieacieee
?iaioe na?oey ? ii??a o?a?eeyoe?? oeoii/e?a.

5. Aea/eoe ?io? oa?iaeieia?/i? aeanoeaino? iaea?eueo aeoeaii? niieoee,
iniaeeai o?, iayai?noue yeeo ? aaaeaieie aeey i?ioea?eoi?/iiai caniao:
aioea?iiene/io ae?th, aieea ia iiceiaee oa ei?iia?iee e?iaiia?a, nenoaio
cn?aeaiiy e?ia?, i?noeaaiaianoacoth/o oa i?ioenoaeiiio aeoeai?noue.

6. A oiiaao noao?ii?/iiai aenia?eiaioo aecia/eoe ia?aiinei?noue ??cieo
aeic niieoee i?e ?? o?eaaeiio aaaaeaii? (1 i?nyoeue): aieea ia ciai?oi?e
aeaeyae, iiaaae?ieo oaa?ei, nia?oi?noue, ooieoe?iiaeueiee noai OeIN,
ia?eoa??eio e?ia, ie?ee, ia/?ieo ? ii?oieia?/io no?oeoo?o aioo??oi?o
i?aai?a. Iaoiaeii aiae?co o?iiiniiieo aaa?aoe?e aeine?aeeoe iooaaaiio
aeoeai?noue aeaii? niieoee.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. A ?iaio? i?aaenoaaeai?
?acoeueoaoe aeine?aeaeaiiy i?ioea?eoi?/ii? aeoeaiino? 20 i?ea?iaeueieo
niieoe ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io, ye? ?ai?oa a yeino?
i?ioea?eoi?/ieo cania?a ia aea/aeenue.

Caaaeyee i?iaaaeaiei aeine?aeaeaiiyi aia?oa aeyaeaia iiaa, aein?
iaa?aeiia a?oia o?i?/ieo niieoe, ye?e i?eoaiaii? i?ioea?eoi?/i?
aeanoeaino?. Na?aae iio?aeieo oe??? a?oie aeyaeaii niieoeo c
eaai?aoi?iei oeo?ii AIE-68 (2,2-ae?ai?iiaeeoai?e aeea?ae?ioei?eae), yea
nai?th aeoeai?noueth a aenia?eiaioao ia oaa?eiao ia?aaaaea? ae?th
a?aeiieo i?ioea?eoi?/ieo cania?a (ei?aea?iio, e?aeiea?io,
iiaiea?iai?aeo) ia aeii?oeiia?e ? oei?eaeaa???a?e iiaeaeyo a?eoi?? ?
i?e??aith?oueny aei ieo ia ?ioeo iiaeaeyo a?eoi?e.

O AIE-68 aeyaeai? oae? oe?ii? aeey aioea?eoi?ea aeanoeaino? ye
aioea?iiene/ia, caeaoi?noue iie?auoaaoe iiceiaee e?iaiia?a,
i?noeaaiaianoacoth/a, i?ioenoaeiiia ae??. Niieoea aeineoue aeia?a
ia?aiineoueny uo?aie i?e noao?ii?/iiio aaaaeaii?. Aiia ia i?iyaey?
iooaaaiii? ae?? ia ee?oeie e?noeiaiai iiceo ieoae.

I?ei?eoaoi?noue ?iaioe i?aeoaa?aeaeaia iaoaioii Oe?a?ie ? 22175 A, IEE
6 NI7D243/04.

Oai?aoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Oai?aoe/ia cia/aiiy
io?eiaieo ?acoeueoao?a iieyaa? a oiio, ui aia?oa aoaiiaeai? oe?ii?
oa?iaeieia?/i? aeanoeaino? 2,2-ae?ai?iiaeeoai?e?a. I?iaaaeai?
aeine?aeaeaiiy a?aee?eee 2,2-ae?ai?iiaeeoai?ee ye iiao a?oio niieoe,
caeaoieo i?iyaeyoe neeueio i?ioea?eoi?/io ae?th, aecia/eee ?o
oiene/i?noue ? aeaye? ?io? iiceoeai? oa?iaeieia?/i? aeanoeaino?.

O 2,2-ae?ai?iiaeeoai?e?a aia?oa aeyaeai? aioea?iiene/ia, i?ioenoaeiiia
ae?y, iiceoeaiee aieea ia iiceiaee e?iaiia?a, i?aeoaa?aeaia
i?noeaaiaianoacoth/a ae?y.

Aeine?aeaeaiiy aeaee ciiao anoaiiaeoe caeaaei?noue aeoeaiino? a?ae
o?i?/ii? no?oeoo?e niieoe, aena?oeeee aieea ai?ii?a ia ?o i?ioea?eoi?/io
aeoeai?noue, ui iiaea aooe aeei?enoaii o?i?eaie i?e iiaeaeueoiio neioac?
niieoe oe??? a?oie c iaoith iiaeaeueoiai oe?eani?yiiaaiiai iiooeo
a?ieia?/ii aeoeaieo ?a/iaei.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. A ?acoeueoao? i?iaaaeaieo
aeine?aeaeaiue aeyaeaia niieoea c eaai?aoi?iei oeo?ii AIE-68 c aenieith
i?ioea?eoi?/iith aeoeai?noueth, yea ia?aaa?oo? ae?th a?aeiieo
i?ioea?eoi?/ieo i?aia?ao?a ei?aea?iio, e?aeiea?io, iiaiea?iai?aeo.
Niieoea i?iyaey? ?io? oe?ii? aeanoeaino?, iaeioiene/ia, a oiiaii
oa?aiaaoe/ieo aeicao aeia?a ia?aiineoueny oaa?eiaie, ia i?iyaey?
iooaaaiii? aeoeaiino? ia ee?oeiao e?noeiaiai iiceo ieoae.

Io?eiai? aeai? aeathoue iiaeeea?noue ?aeiiaiaeoaaoe o?i?eai ?ic?iaeoe
iaoiae ? oiiae caaiaenueeiai neioaco niieoee, a oa?io?i?eai noai?eoe
e?ea?nueeo oi?io AIE-68 c iaoith anaa?/iiai aeine?aeaeaiiy ?? a yeino?
iioaioe?eiiai i?ioea?eoi?/iiai caniao a?o/eciyiiai iioiaeaeaiiy.

Ai?iaaaeaeaiiy a i?aeoeeo. Iaoa??aee aeine?aeaeaiiy ai?iaaaeaeaii a
eaeoe?eiee eo?n ii oa?iaeieia?? a oaiao “I?ioea?eoi?/i? oa
i?noeaaiaianoacoth/? caniae” a A?iieoeueeiio ? Eoaaineiio aea?aeaaieo
iaaee/ieo oi?aa?neoaoao, Aei?i?iiao?ianuee?e ? Oa?iii?euenuee?e
iaaee/ieo aeaaeai?yo.

Iniaenoee aianie caeiaoaa/a a iaea?aeaiiy iaoeiaeo ?acoeueoao?a, ui
aeiinyoueny ia caoeno

Aeena?oaoe?eia ?iaioa ? naiino?eiei iaoeiaei aeine?aeaeaiiyi aaoi?a.
Caeiaoaa/ai iniaenoi i?iaaaeaii ?ioi?iaoe?eiee iiooe, aecia/aiiy aino?i?
oiene/iino? niieoe, aeine?aeaeaiiy i?ioea?eoi?/ii? aeoeaiino? ia
aeii?oeiia?e, oei?eaeaa???a?e, oei?eaeeaeueoe??a?e, no?ioaioeiia?e,
iino?oai?/i?e ?aia?ooc?ei?e iiaeaeyo a?eoi?e, aea/aiiy
i?ioeo?a?eeyoi?ii?, i?noeaaiaianoacoth/i?, i?ioenoaeiiii?,
aioea?iiene/ii? ae??, aieeao ia ei?iia?iee ? iiceiaee e?iaiia?a,
noaoenoe/ia ia?iaea aeaiieo, ioi?ieaiiy aeena?oaoe?eii? ?iaioe ?
aaoi?aoa?aoo.

Aiae?c a?noieia?/ieo i?aia?ao?a i?iaaaeaii i?e eiinoeueoaoe?? i?io.
A.A. A?eo?i??iaa,  aiae?c iooaaaiii? aeoeaiino? — i?e eiinoeueoaoe??
e.i.i. E.A. Ee?ian, ca ui aaoi? aeneiaeth? ?i aeeaieo iiaeyeo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ia:

-Ia?oiio iaoe?iiaeueiiio c’?cae? oa?iaeieia?a Oe?a?ie “No/ani? i?iaeaie
oa?iaeieia??” (i. Iieoaaa, 27-29 aa?aniy 1995 ?.);

-II Iaoeiai-i?aeoe/i?e eiioa?aioe?? e?ea??a oa?eoi??aeueiiai iaaee/iiai
ia’?aeiaiiy i?nueei? ee?i?/ii? e?ea?i? N4 (i. A?iieoey, 15-16 o?aaiy
1995 ?.);

-II Oe?a?inuee?e iaoeia?e eiioa?aioe?? c i?aeia?iaeiith o/anoth
“Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??» (A?iieoey, 6-8 aeiaoiy 1998
?.)

— Iaoeiai-i?aeoe/i?e eiioa?aioe?? eaoaae?e i?iiaaeaaoeee aioo??oi?o
oai?ia “Aeooaeuei? i?iaeaie oa?ai??” (A?iieoey, 24-25 ethoiai 1999 ?.).

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 9 iaoeiaeo ?ia?o, c ieo
3 aac ni?aaaoi??a. Na?aae ieo 3 noaoo? a i?ia?aeieo iaoeiaeo aeo?iaeao,
5 ?ia?o a iaoa??aeao ? oacao eiioa?aioe?e, a oiio /ene? c i?aeia?iaeiith
o/anoth, io?eiaii 1 iaoaio Oe?a?ie.

No?oeoo?a oa ia?i aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia
145 noi??ieao iaoeiiieniiai oaenoo ? neeaaeathoueny c anooio, iaeyaeo
e?oa?aoo?e, ?icae?eo “Iaoa??aee ? iaoiaee aeine?aeaeaiiy”, 4 aeaa
aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, nieneo aeei?enoaii?
e?oa?aoo?e, ui i?noeoue 237 aeaea?ae, na?aae yeeo 101 a?o/eciyieo oa 136
?iicaiieo aaoi??a. Aeena?oaoe?y ?ethno?iaaia 9 oaaeeoeyie ? 19
iaethieaie.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Iaoa??aeii aeine?aeaeaiiy aoee 20
iiaeo niieoe — iio?aeieo ae?ai?iiaeeoai?eo ? aeeaaiciae?acai?io.
Niieoee i?aaenoaaeythoue niaith ??ci? nie? 2,2-ae?ai?iiaeeoai?eo oa
aeeaaicd,f1,3ae?acai?io. An? niieoee neioaciaai? o?i?eaie Aeiiaoeueeiai
oi?aa?neoaoo i?ae ea??aieoeoaii aeioeaioa A.I. Ia?oooie. Aeine?aeaeaiiy
?o aeoeaiino? i?iaaaeaii ia 558 ieoao, 413 uo?ao, 28 ii?nueeeo
naeieao, 59 e?oeao, 12 e?ieyo (anueiai 1070 oaa?ei) c aeei?enoaiiyi
caaaeueiii?eeiyoeo a oa?iaeieia?? iaoiae?a.

Aino?o oiene/i?noue an?o niieoe aea/aee ia a?eeo ieoao i?e
aioo??oiueii/a?aaeiiiio aaaaeaii?, a oiene/i?noue AIE-68 aecia/aee
oaeiae ia a?eeo uo?ao i?e aioo??oiueiaaiiiio aaaaeaii?. Ia?aiao?e
aino?i? oiene/iino? aecia/aee iaoiaeii E?/o?eueaea-O?eeieniia.

Ne?ei?iaia? aeine?aeaeaiiy i?ioea?eoi?/ii? aeoeaiino? i?iaiaeeee ia
a?eeo uo?ao c aeei?enoaiiyi aeii?oeiiai? iiaeae? a?eoi??. ??ciiieaiiaa
aea/aiiy i?ioea?eoi?/ieo aeanoeainoae iaea?eueo aeoeaii? niieoee
AIE-68 i?iaiaeeee ca?aeii ?aeiiaiaeiaaieo Oa?ieii?oaoii IIC Oe?a?ie
aeii?oeiiai?, oei?eaeeaeueoe??ai?, oei?eaeaa???ai?, no?ioaioeiiai?
iiaeaeae a?eoi?e, a i?ioeo?a?eeyoi?io ae?th aea/aee ia iiaeae?
iino?oai?/ii? ?aia?ooc?eii? o?a?eeyoe?? ia eioao ? oeyoii aecia/aiiy
ii?iao o?a?eeyoe?? oeoii/e?a ye ?ioaeoiiai i?iea?aeo uo??a, oae ? ia
oii? ?caae?eiiaiai o?aaeaiiy.

Aioea?iiene/io ae?th niieoee aea/aee a oiiaao aino?i? a?iien??, yeo
aeeeeeaee ia?aoeneaiiyi o?aoa? o a?eeo uo??a. Ca aeiiiiiaith AEA
?a?no?oaaee o?eaae?noue nei?i/aiue na?oey oaa?ei eiio?ieueii? ?
aeine?aeii? a?oie. Inoaii?i aei ia?aoeneaiiy o?aoa? i?aeoe??ii aaiaeeee
niieoeo AIE-68 a aeic? 20 ia/ea.

Aieea AIE-68 ia iiceiaee e?iaiia?a aeine?aeaeoaaee ia ia?eioeciaaieo
a?eeo uo?ao iaoiaeii ia?aa’ycee iaio niiieo a?oa??e c ianooiiith ?o
ia?a??ceith. *a?ac aeiao a?aoiaoaaee e?euee?noue aeaeeaoeo oaa?ei a
eiio?ieuei?e a?oi? ? a a?oi?, aea iiia?aaeiuei i?aeoe??ii aaiaeeee
AIE-68.

I?noeaaiaianoacoth/o ae?th AIE-68 aea/aee ia ii?nueeeo naeieao iaoiaeii
Atheuea?eia-Oaeaea.

I?ioenoaeiiio ae?th AIE-68 aecia/aee ia ieoao ca iaoiaeii iaeneiaeueiiai
aeaeo?inoaeiiiiai oieo.

I?e an?o ia?a?aoiaaieo aeine?aeaeaiiyo aeoeai?noue AIE-68
ii??aithaaee c ae??th a?aeiieo e?ea?nueeeo cania?a.

Aieea niieoee AIE-68 ia aeaeo?io?c?ieia?/i? iieacieee ?iaioe na?oey
aea/aee ia e?oeao, aecia/ath/e ii AEA:

— /anoioo nei?i/aiue na?oey;

— o?eaae?noue ?ioa?aaeo PQ;

— o?eaae?noue aeaeo?e/ii? nenoiee na?oey (?ioa?aaeo QT);

— /an a?aeiiaeaiiy ooieoe?? neioniaiai aocea;

— i?ia?aei?noue ao??iaaio?eeoey?iiai aocea oeyoii aecia/aiiy aioa- ?
?ao?ia?aaeii? oi/ee Aaieaaaoa.

Aieea AIE-68 ia ia’?iio oaeaee?noue ei?iia?iiai e?iaioieo oa
a?oa??aeueiee oene aea/aee ia e?oeao ca iaoiaeii I.A. Eaaa??ii?.

Ae?th AIE-68 ia iieacieee nenoaie cai?oaiiy e?ia? ioe?ithaaee ia a?eeo
uo?ao caaaeueiii?eeiyoeie a ee?ieoe? iaoiaeaie.

Noao?ii?/io oiene/i?noue ? nooi?iue aacia/iino? o?eaaeiai aaaaeaiiy
AIE-68 aea/aee ia a?eeo uo?ao i?e aioo??oiueii/a?aaeiiiio aaaaeaii?
niieoee ia i?ioyc? 1 i?nyoey. Ci?ie a noai? oaa?ei i?ae aieeaii ??cieo
aeic niieoee a ii??aiyii? c eiio?ieai aecia/aee ii noai?,
?aeiiaiaeiaai?e Oa?ieii?oaoii, ? ca aeiiiiiaith ai?iaiaaieo
o?c?ieia?/ieo, a?io?i?/ieo, a?noieia?/ieo iaoiae?a.

Aeey aecia/aiiy iooaaaiii? aeoeaiino? AIE-68 aeei?enoiaoaaee iaoiae
iaoaoaciiai aiae?co ee?oei e?noeiaiai iiceo ieoae.

?acoeueoaoe aeine?ae?a aoei i?aeaeaii noaoenoe/iiio aiae?co c
aeei?enoaiiyi e?eoa??th Nothaeaioa A aeiaaeeao c aeueoa?iaoeaiei
aa??thaaiiyi iciae aeei?enoiaoaaee oi?ioee aeey a?iii?aeueiiai
?iciiae?eaiiy, ioeueiaee (100%) aoaeo ioe?ithaaee ca aeiiiiiaith oi?ioee
aai aea? Aa?aeaia oa oi/iiai e?eoa??th O?oa?a. EAe50 ? AAe50 niieoe
aecia/aee iaoiaeii E?/o?eueaea-O?eeieniia. I?ioea?eoi?/iee ?
i?ioenoaeiiiee ?iaeaene aecia/aee ye a?aeiioaiiy EAe50 aei AAe50.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. Aino?a oiene/i?noue
niieoe a aeine?aeao ia ieoao eieeaaeanue a?ae 290 aei 428 ia/ea.
Oiene/i?noue iaea?eueo aeoeaii? niieoee AIE-68 ia ieoao i?e
aioo??oiueii/a?aaeiiiio aaaaeaii? neeaea 377,0 296,6:478,8 ia/ea, ia
uo?ao i?e aioo??oiueiaaiiiio aaaaeaii? 120,0 100,0:144,0 ia/ea.

A eiio?ieueieo aeine?aeao aeii?oei a aeic? 30 iea/ea a 10 aeine?aeao c
10 (100,07,65%) aeeeeeaa /a?ac 1-4 oaeeeie i?ney aioo??oiueiaaiiiai
aaaaeaiiy ?icaeoie a?eoi??, yea o?eaaea aei 1 aiaeeie. Aiia i?iyaeyeanue
/anoith iie?oiiiith a?oiiaith oeoii/eiaith ? iaaeoeoii/eiaith
aeno?anenoie??th, ia?aoo?iiyi ia?aaena?aeue ? oeoii/e?a. A a?eueoino?
aeiaaee?a a?eoi?y cae?i/oaaeanue nia?oth oaa?ei.

Ia aeii?oeiia?e iiaeae? a?eoi?? i?iaaaeaii ne?ei?iaiaa aeine?aeaeaiiy
i?ioea?eoi?/ii? aeoeaiino? an?o 20 niieoe. ?o aaiaeeee a aeicao, ui
neeaaeathoue 5% a?ae EAe50. Aeoeai?noue niieoe ? o?eaae?noue ?o ae??
i?aaenoaaeaia a oaae. 1.

Oaaeeoey 1

I?ioea?eoi?/ia aeoeai?noue iio?aeieo ae?ai?iiaeeoai?eo oa
aeeaaiciae?acai?io ia aeii?oeiia?e iiaeae? a?eoi?? o uo??a, Im

Oeo? niieoeeAeica, ia/eaE?euee?noue

aeine?ae?a*anoioa a?aeiiaeaiiy neioniaiai ?eoioO?eaae?noue a?aeiia-eaiiy
neioniaiai ?eoio,
oaaaniethoia%AIE-69207685,713,23*5,42,19AIE-352077100,09,93*1,90,32AIE-6
8191010100,07,65*34,08,12AIE-301877100,09,93*13,76,24AI-65167685,713,23*
12,66,41AIE-27157685,713,23*7,91,82AO-13207457,118,71*1,00,39AIE-3215771
00,09,93*11,12,92AO-141877100,09,93*15,45,65AI-661677100,09,93*3,41,06AI
E-921577100,09,93*8,32,94AIE-64155480,017,89*0,90,24AAA-11205240,021,910
,30,2AAA-817500,012,370AIE-107155240,021,910,40,29AIE-76205240,021,910,3
0,15AIE-63185120,017,890,10,1AAE128205120,017,890,20,2AAA-6515500,012,37
0AA-4819500,012,370I?ei?oea: ciaeii * iicia/aia aeinoia??ia ??cieoey c
eiio?ieai (P0,05).

C 20 aeine?aeaeoaaieo niieoe 12 i?iyaeee caeaoi?noue eoi??oaaoe
aeii?oeiiao a?eoi?th. Na?aae ieo a?eueoo aeoeai?noue i?iyaeee niieoee
AIE-68, AIE-35, AIE-30, AIE-32, AO-14, AI-66, AIE-92. Aiie eoi??oaaee
a?eoi?th a 100% aeine?ae?a. Aeaui iaioee aoaeo i?iyaeyee niieoee AIE-69,
AI-65, AIE-27, AO-13 ? AIE-64. Aiie eoi??oaaee a?eoi?th a 57-85%
aeine?ae?a. An? aeua ia?a?aoiaai? niieoee ? ??cieie nieyie
2,2-ae?ai?iiaeeoai?eo. Na?aae ieo ii o?eaaeino? ae?? iaea?eueo aeoeaiith
aeyaeeanue niieoea AIE-68. ?? i?ioea?eoi?/iee aoaeo i?iaeiaaeoaaany a
na?aaeiueiio 34,08,12 oa. O?eaae?noue ae?? ?ioeo niieoe aoea cia/ii
iaiueoith. Iio?aeia 2,2-ae?ai?iiae?oai?eo i?ae eaai?aoi?iei oeo?ii
AAA-11 ? an? aeine?aeaeoaai? niieoee aeeaaiciae?acai?io i?iyaeyee
noaoenoe/ii iacia/eiee aoaeo.

Iaea?eueo aeoeaia niieoea AIE-68 aoea aeine?aeaeaia ia aeii?oeiia?e
iiaeae? a?eoi?? a ??cieo aeicao: 9,5; 4,7 ? 1 ia/ea. Aiie noaiiaeyoue
i?eaeecii 8, 4 ? 1% EAe50 aeey uo??a. Aeyaeeinue, ui iaa?oue a aeic? 1
ia/ea AIE-68 a 100% aeine?ae?a ei?ioei/anii eoi??oaaea aeii?oeiiao
a?eoi?th (oaae. 2). O an?o aeiaaeeao aoaeo ?icaeaaany a e?ioe?
aioo??oiueiaaiiiai aaaaeaiiy niieoee aai ia ia?o?e oaeeei? i?ney ??
aaaaeaiiy. O?eaae?noue ae?? AIE-68 aoea i?yii i?iii?oe?eia aeic? ?
ci?ithaaeanue a?ae 1-5 oaeeei i?e aeic? 1 ia/ea aei 90 oaeeei i?e aeic?
19 ia/ea. I?e aaaaeaii? aeice 9,5 ia/ea aoaeo o?eaaa a na?aaeiueiio
15,74,14 oa.

Oaaeeoey 2

I?ioea?eoi?/ia aeoeai?noue AIE-68, ei?aea?iio, e?aeiea?io oa
iiaiea?iai?aeo ia aeiieoeiia?e iiaeae? a?eoi?? o uo??a, Im

Oeo? niieoeeAeica, ia/eaE?euee?noue aeine?ae?a*anoioa a?aeiiaeaiiy
neioniaiai ?eoioO?eaae?noue a?aeiiaeaiiy neioniaiai ?eoio,
oaaaniethoia%AIE-68191010100,07,65*34,08,12*9,51010100,07,65*15,74,14*4,
71010100,07,65*5,40,73*11010100,07,65*2,10,51Ei?aea?ii1010330,012,711,00
,56E?aeiea?i1010330,012,710,90,48Iiaiea?iai?ae2010440,013,581,70,84
I?ei?oea: ciaeii * iicia/aia aeinoia??ia ??cieoey c ei?aea?iiii,
e?aeiea?iii, iiaiea?iai?aeii (P0,01).

Na?aaeiy aoaeoeaia aeica (AAe50) AIE-68, yea ii?iae?coaaea ii?ooaiee
aeii?oeiii ?eoi na?oey ia ia??iae a?eueoa 5 oa, aei??aithaaea 2,5
[0,966,50] ia/ea, ui noaiiaeoue 2% a?ae EAe50 niieoee aeey uo??a.
I?ioea?eoi?/iee ?iaeaen AIE-68 aei??aith? 48.

Ii i?ioea?eoi?/i?e aeoeaiino? ia aeii?oeiia?e iiaeae? a?eoi?? AIE-68
ia?aaa?ooaaea ae?th ei?aea?iio ? e?aeiea?io (10 ia/ea), ye? o 3
aeiaaeeao ?c 10, oa iiaiea?iai?aeo (20 ia/ea), yeee o 4 aeiaaeeao ?c 10,
o?eueee ei?ioei/anii a?aeiiaethaaee ii?ooaiee aeii?oeiii ?eoi na?oey.

A aeine?aeao c iiia?aaeaeaiiyi aeieeiaiiy aeii?oeiiai? a?eoi??
anoaiiaeaii, ui AIE-68 a aeic? 19 ia/ea, aaaaeaia ca 2-5 oaeeei aei
aeii?oeio cao?eio? ?icaeoie aeii?oeiiai? a?eoi?? a na?aaeiueiio ia 10
oaeeei, oiae? ye a eiio?ieueieo aeine?aeao aeii?oeiiaa a?eoi?y
?icaeaaeanue ia 1 — 4 oaeeei?. Ca?eueoaiiy aeice niieoee aei 40 ia/ea
a?aeaeaeyei ?icaeoie a?eoi?? a na?aaeiueiio ia 22 oaeeeie, i?e oeueiio a
2 aeiaaeeao c 5 a?eoi?y acaaae? ia aeieeea.

Oaeei /eiii, AIE-68 ia aeii?oeiia?e iiaeae? a?eoi?? i?iyaey? neeueiee,
noaa?eueiee ? aeineoue o?eaaeee i?ioea?eoi?/iee aoaeo. Ii aeoeaiino? ?
o?eaaeino? ae?? aiia cia/ii ia?aaa?oo? a?aeii? i?ioea?eoi?/i? caniae
ei?aea?ii, e?aeiea?i ? iiaiea?iai?ae. Niieoea caeaoia ia o?eueee
eoi??oaaoe aeii?oeiiao a?eoi?th, a ? a?aeaeaeyoe /an ?? aeieeiaiiy.

Aeniea aeoeai?noue AIE-68 ia aeii?oeiia?e iiaeae? a?eoi?? niiioeaea aei
aea/aiiy ?? aeoeaiino? ia ?ioeo iiaeaeyo a?eoi?e ? aeine?aeaeaiiy
ae?oaeo oa?iaeieia?/ieo aeanoeainoae.

A eiio?ieueieo aeine?aeao oaeaeea aioo??oiueiaaiia aaaaeaiiy uo?ai 10%
?ic/eio eaeueoe?th oei?eaeo a aeic? 2,2 ie/ea /a?ac 5-10 naeoiae a 10
aeine?aeao c 10 (100,07,65%) aeeeeeaei ?icaeoie a?eoi??, yea ia?aoiaeeea
a o?a?eeyoe?th oeoii/e?a ? a a?eueoino? aeine?ae?a cae?i/oaaeanue
caaeaaeth oaa?ei ia i?ioyc? 1 oaeeeie.

I?io?eaeoe/ia aioo??oiueiaaiia aaaaeaiiy niieoee AIE-68 a aeic? 30
ia/ea iiia?aaeaeaei ?icaeoie a?eoi?? a 5 aeiaaeeao ?c 7 (a 71,414,3%). A
aeic? 20 ia/ea iiae?aiee aoaeo aoa aeyaeaiee eeoa a 2 aeiaaeeao c 8
(25,013,05%), a a aeic? 10 ia/ea a 1 aeine?ae? c 8 (12,59,97%).
Ei?aea?ii (10 ia/ea) iiia?aaeaeaa ?icaeoie a?eoi?? a 4 aeine?aeao c 10
(40,013,56%), a e?aeiea?i a 3 aeine?aeao c 10 (30,012,71%).

Io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui AIE-68 a aeicao 10 ? 20 ia/ea
iaei aieeaa? ia ?icaeoie oei?eaeeaeueoe??ai? a?eoi?? ? eeoa a aeic? 30
ia/ea i?iyaey? i?ioea?eoi?/iee aoaeo (P0,05). Aoaeoeai?noue i?aia?ao?a
ii??aiyiiy ei?aea?iio ? e?aeiea?io oaae aoea iacia/iith.

sse a?aeiii, oei?eaeaa???aa iiaeaeue ii?ooaiue na?oeaaiai ?eoio
i?iaiaeeoueny ia e?ieyo aac canoinoaaiiy ia?eico a oiiaao a?eueii?
iiaaae?iee oaa?eie, ui aea? iiaeeea?noue aeeeth/eoe aieea ia?eico ia
i?iea?ae. A oiae? aeine?ae?a oaa?eie, ye i?aaeei, caeeoathoueny aeeaeie,
?o /a?ac 7-10 aei?a iiaeia aeei?enoiaoaaoe aeey iiaoi?ieo
aeine?aeaeaiue.

Aioo??oiueiaaiii aaaaeaia e?ieyi niieoea AIE-68 a aeic? 10 ia/ea /a?ac
1-4 oaeeeie i?ney ?icaeoeo oei?eaeaa???ai? a?eoi?? a?aeiiaethaaea
ii/aoeiaee neioniaee ?eoi o an?o 7 oaa?ei, oiaoi a 100,09,93%
aeine?ae?a. Acyo? aeey ii??aiyiiy ei?aea?ii (5 ia/ea) ? e?aeiea?i (10
ia/ea) i?iyaeyee aoaeo a 6 aeine?aeao c 10 (60,013,59%).

Ioaea niieoea AIE-68 ia oei?eaeaa???a?e iiaeae? a?eoi?? i?iyaey?
i?ioea?eoi?/io ae?th, yea ia?aaa?oo? aeoeai?noue e?aeiea?io ? ei?aea?iio
(P0,05),

A eiio?ieueieo aeine?aeao No?ioaioei-E aeeeeeaa ?icaeoie a?eoi?? o
aeaeyae? iaaeoeoii/eiai? ? oeoii/eiai? aeno?anenoie??, ia?ieneciaeueii?
oeoii/eiai? oao?ea?ae??, yea i?iaeiaaeoaaeanue 13,03,63 oaeeei,
cae?i/oaaeanue iiyaith ?ae?iaaio?eeoey?iiai ?eoio ? caaeaaeth oaa?ei.
AIE-68 a aeic? 10 ia/ea a?aeiiaethaaea ii?ooaiee no?ioaioeiii ?eoi
na?oey ia 11,03,63 oaeeei o 4 aeiaaeeao ?c 7, oiaoi o 57,015,66%
aeine?ae?a (P0,05). Ae?y niieoee ?icaeaaeanue /a?ac 4-5 oaeeei i?ney
aaaaeaiiy. Caaaeii aieea AIE-68 ia no?ioaioeiiao a?eoi?th iiaeia
aecia/eoe ye iii??iee.

A eiio?ieueieo aeine?aeao ia iiaeae? iino?oai?/ii? ?aia?ooc?eii?
a?eoi?? ?aioiaa a?aeiiaeaiiy e?iaiia?ao a ?oai?ciaaiiio i?iea?ae? e?oie
aeeeeeaei ia i?ioyc? ia?oeo 5 oaeeei o?a?eeyoe?th oeoii/e?a na?oey a 8
aeiaaeeao c 10 (80,0±12,65%). Niieoea AIE-68, aaaaeaia ca 5 oaeeei aei
?icioneo e?aaoo?e a aeic? 10 ia/ea, iiia?aaeaeoaaea ?icaeoie o?a?eeyoe??
oeoii/e?a a 7 aeiaaeeao c 10, oiaoi a 70,012,71% aeine?ae?a. C ieo o 3
oaa?ei ?aia?ooc?y i?ioiaeeea aac ii?ooaiue ?eoio na?oey c iinooiiaei
cieeiaiiyi i?iya?a ?oai??, a a 4 aeine?aeao i?ney ?icioneo e?aaoo?e
?icaeaaeanue ei?ioei/ania a?eoi?y o aeaeyae? oeoii/eiai? aeno?anenoie??
? ia?ieneciaeueii? oeoii/eiai? oao?ea?ae??, aea o?a?eeyoe?y oeoii/e?a
i?e oeueiio ia aeieeaea. O iaei??? oaa?eie oeoii/eiaa aeno?anenoie?y ?
ia?ieneciaeueia oeoii/eiaa oao?ea?ae?y aeieeea i?ae /an ?oai?? ua aei
?icioneo e?aaoo?e ? aoea eoi??oaaia aaaaeaiiyi AIE-68. Ei?aea?ii (5
ia/ea) iiia?aaeaeaa ?icaeoie o?a?eeyoe?? oeoii/e?a a 3 aeiaaeeao c 6
(50,016,6%), a e?aeiea?i (10 ia/ea) a 3 aeiaaeeao c 5 (60,017,3%)
aeine?ae?a.

Oaeei /eiii, ia iiaeae? iino?oai?/ii? ?aia?ooc?eii? a?eoi?? AIE-68
i?iyaey? aeinoia??io i?ioea?eoi?/io ae?th (P0,05), yea i?e??aith?oueny
aei ae?? ei?aea?iio ? e?aeiea?io.

I?ae aieeaii AIE-68 (10 ia/ea) ca?eueooaaany (?0,05) ii??a o?a?eeyoe??
oeoii/e?a o ?ioaeoieo uo??a c 2,870,26 A aei 4,130,40 A (ca?eueoaiiy ia
43%), aea ae?y niieoee aoea ei?ioei/ania. Aaaaeaiiy AIE-68 (10 ia/ea) ia
oii? ?caae?eiiaiai o?aaeaiiy i?iea?aeo ca?eueooaaei (?0,01) cieaeaiee
?caae?eiii ii??a o?a?eeyoe?? oeoii/e?a c 1,900,15 aei 3,500,43 A
(ca?eueoaiiy ia 84%), ia ia?o?e oaeeei? i?ney aaaaeaiiy (oaae. 3). *a?ac
5 oaeeei i?ney aaaaeaiiy niieoee ii??a o?a?eeyoe?? oeoii/e?a
ca?eueooaaany (?0,01) aei 3,900,64 A (ca?eueoaiiy ia 105,3%), iaeiae
/a?ac 15 oaeeei i?aeaeuaiiy neeaaeaei eeoa 47,4%. Acyoee aeey
ii??aiyiiy e?aeiea?i a aeic? 10 ia/ea c?aco i?ney aaaaeaiiy i?aeaeuoaaa
(?0,001) cieaeaiee ?caae?eiii ii??a o?a?eeyoe?? oeoii/e?a c 2,930,37
aei 6,930,82 A (ia 136,5%), /a?ac 5 oaeeei ii??a ??aiyany 7,210,82 A
(i?aeaeuaiiy ia 146%), /a?ac 15 oaeeei ia — 6,430,92 A (ca?eueoaiiy ia
119,5%).

Oaaeeoey 3

Aieea AIE-68 ? e?aeiea?io ia ii??a o?a?eeyoe?? oeoii/e?a i?e
?caae?eiiaiio o?aaeaii? i?iea?aeo, Im

Iacaa

niieoee ?

aeicanIi??a o?a?eeyoe?? oeoii/e?a, Aaeo?aeiee /a?ac 15 oa i?ney aaaaeai-

iy ?caae?eio i?ney aaaaeaiiy niieoeeia 1 oaia 5 oaia 15 oaAIE-68,

10 ia/ea

10

3,550,321,900,15 ?0,001

-46,5%3,500,43

?0,01

+84,2%3,900,64

?0,01 +105,3%2,800,32

?0,05

+47,7%E?aeiea?i, 10 ia/ea

7

4,430,152,930,37

?0,02

-33,9%6,930,82

?0,001

+136,5%7,210,82

?0,001 +146,0%6,430,92

?0,01 +119,5%I?ei?oea: ciaeii + iicia/aii ca?eueoaiiy, ciaeii —
ciaioaiiy ii?iao o?a?eeyoe?? oeoii/e?a.

Oaeei /eiii, AIE-68 a aeic? 10 ia/ea i?aeaeuoaaa cieaeaiee ?caae?eiii
ii??a o?a?eeyoe?? oeoii/e?a (P0,01), aea ii aoaeoeaiino? iinooiaany
e?aeiea?io.

AIE-68 a aeic? 10 ia/ea aeinoia??ii (?0,05) ciaioo? /anoioo na?oeaaeo
nei?i/aiue (*NN) c ii/aoeiaeo 18813,15 aei 14310,28 (ia 23,9%) ?
ca?eueoo? (?0,05) /an a?aeiiaeaiiy ooieoe?? neioniaiai aocea (*AONA) c
0,380,024 aei 0,490,044 (ia 28,9%). I?ae aieeaii niieoee i?iyaeyeanue
oaiaeaioe?y aei ciaioaiiy i?ia?aeiino? ao??i-aaio??eoey?iiai aocea ia
12,8% ? ?ao?ia?aaeiiai i?iaaaeaiiy /a?ac ao??i-aaio?eeoey?iee aocie ia
20,9% (oaae. 4). Io?eiai? ?acoeueoaoe iiaeooue na?ae/eoe i?i
caeaoi?noue AIE-68 i?eai?/oaaoe neioniaee aocie. Oaea aeanoea?noue
niieoee iiaea aooe aeei?enoaia i?e e?eoaaii? neioniaeo a?eoi?e. A oie
aea /an i?e neiae?ii? neaaeino? neioniaiai aocea niieoeo iaiao?aeii
aeei?enoiaoaaoe c iaa?aaei?noth.

Oaaeeoey 4

Aieea AIE-68 (10 ia/ea) ia aeaeo?io?c?ieia?/i? iieacieee

?iaioe na?oey e?oie, Im

IieacieenAeo?aei? aeai?*a?ac 15 oa i?ney aaaaeaiiy AIE-68 ??cieoey
aeaieo a %*NN7188,0±13,15143,0±10,28* -23,9%?ioa?aae PQ,
n70,067±0,0030,074±0,008+ 10%?ioa?aae QT, n70,22±0,0080,27±0,024
+22,7%*AONA, n70,38±0,0240,49±0,044* +28,9%Oi/ea
Aaieaaaoa7334,0±13,91291,0±19,66 -12,8%?ao?ia?aaeia oi/ea
Aaieaaaoa5286,0±21,52246,6±30,47 -20,9% I?ei?oea: ciaeii — iicia/aii
ciaioaiiy iieacieea, ciaeii + ca?eueoaiiy, ciaeii * — aeinoia??ia
??cieoey c aeo?aeieie aeaieie (?<0,05) I?ae aieeaii AIE-68 (10 ia/ea) a?oa??aeueiee oene ei?ioei/anii ciaiooaaany ia 17,784,49 ii ?o. no., ia'?iia oaeaee?noue ei?iia?iiai e?iaioieo ciaiooaaeanue ia 5 oa, c 6,01,15 ie/oa aei 5,01,39 ie/oa, a iio?i ca?eueooaaeanue ia 10 ? 30 oa, a?aeiia?aeii aei 6,651,99 ? 7,22,60 ie/oa, iaeiae an? oe? ci?ie aoee noaoenoe/ii iacia/ei? (?0,5). A ie?aieo aeiaaeeao, eiee a?oa??aeueiee oene ia ciaiooaaany, ei?iia?iee e?iaioie ca?eueooaaany a 1,5-2,9 ?aca. A oiiaao aino?i? a?iien?? aeeeeeaii? ia?aoeneaiiyi o?aoa?, AIE-68 (20 ia/ea) ca?eueoo? /an /an aeaeo?io?c?ieia?/ii? aeoeaiino? na?oey uo??a c 9,3 7,59:11,01 oa aei 11,5 10,04:12,96 oa. Oae? aeai? na?ae/aoue i?i oa, ui ii a?aeiioaiith aei i?ia?aeii? nenoaie na?oey AIE-68 i?iyaey? aioea?iiene/io ae?th. Aeaia ae?y niieoee aeoaea aaaeeeaa aeey iioaioe?eiiai i?ioea?eoi?/iiai caniao. Ca?eueoaiiy i?ae aieeaii AIE-68 /ano, ia i?ioyc? yeiai niinoa??aa?oueny aeaeo?e/ia aeoeai?noue na?oey a oiiaao aino?i? a?iien?? a noeoiiino? c ae?aaeaiith i?ioeo?a?eeyoi?iith ae??th, aea? iiaeeea?noue aeoeaii aeei?enoiaoaaoe aeaio niieoeo aeey i?iaaaeaiiy ?aai?iaoe?eieo caoiae?a. Iiaeiaaeaiiy oa?i?io aeaeo?e/ii? aeoeaiino? i?ia?aeii? nenoaie na?oey i?ae /an ?aai?iaoe?? ca?eueoo? oaine ia a?aeiiaeaiiy ?eoio oa iaoai?/ii? aeoeaiino? na?oey. Niieoea AIE-68 (20 ia/ea) iie?auo? iiceiaee e?iaiia?a, ca?eueooth/e aeaeeaaiiy uo??a i?e ia?aaycoe? iaio niiieo a?oa??e c 20,012,65% aei 80,012,65% (P0,01). AIE-68 a aeicao, ui noaiiaeyoue 7,5 - 30% a?ae EAe50, i?iyaey? i?ioenoaeiiio ae?th, iiia?aaeaeoth/e ?icaeoie aenoaic?e caaei?o e?ioe?aie o ieoae ia iiaeae? iaeneiaeueiiai aeaeo?inoaeiiiiai oieo. ?? AAe50 neeaaea? 46,06,09 ia/ea, i?ioenoaeiiiee eiaeaen - 8,19. Ii i?ioenoaeiii?e aeoeaiino? AIE-68 aeaui ia?aaaaea? oaiiaa?a?oae, i?ioenoaeiiiee ?iaeaen yeiai, ca aeaieie O.A. Oa?aoooe (1983), noaiiaeoue 6,42. ?ic/ei niieoee AIE-68 a 0,25% eiioeaio?aoe?? aeeeeea? o ii?nueeeo naeiie ?io?eueo?aoe?eio aianoac?th o?eaae?noueth 35-64 oaeeeie. ?iaeaen aianoac?? niieoee neeaaea? 51,04,11. Acyoee aeey ii??aiyiiy iiaiea?i, o o?e aea eiioeaio?aoe??, aeeeeea? o oeeo aea oaa?ei i?eaeecii oaeo ae aianoac?th. ?iaeaen aianoac?? iiaiea?ia noaiiaeoue 46,02,16. Niieoea AIE-68, aaaaeaia ca 30 oaeeei aei caai?o e?ia? a aeic? 30 ia/ea i?aeoe??ii, ia ci?ith? iieaciee?a cai?oaiiy e?ia? uo??a. AIE-68 - iaeioiene/ia niieoea. A aeicao 5 ? 10 ia/ea niieoea aeia?a ia?aiineoueny uo?aie ? ieoaie i?e aioo??oiueii/a?aaeiiiio aaaaeaii? ia i?ioyc? 1 i?nyoey. Aiia ia aeeeeea? caaeaae? oaa?ei, ia ci?ith? ?o ciai?oiueiai aeaeyaeo, ia i?iyaey? nooo?aiai aieeao ia ooieoe?? OeIN, ia/?iee oa a?noino?oeoo?o aioo??oi?o i?aai?a. Oae? aeice aeeeeeathoue eeoa iiaiie??a'y i?iea?aeo, eaaaiue, ia/?iee, ie?ie, naeac?iee, ca?eueoaiiy a inoaii?e e?ioi?aeieo oie?eoe?a, ?icoe?aiiy O ? A cii c i?ie?oa?aoe??th e?ioioeeo?a, ca?eueoaiiy ae?o?aco ? OIA. Ca?eueoaiiy aeice AIE-68 aei 40 ia/ea (10% a?ae EAe50) i?e o?eaaeiio aaaaeaii? aeeeeea? i?eai?/aiiy OeIN, ciaioo? ae?o?ac, ci?ith? ?I na/?, aieeaa? ia aiaeie?eiio nenoaio (ca?eueoo?oueny aaenica na/?), ia e?i?aeiee iai?i (cieaeo?oueny ??aaiue oieanoa?eio), aieeaa? ia a?noino?oeoo?o ia/?iee (?icaeaa?oueny aee?iaa ae?no?io?y), i?enei?th? OIA. Iaeiae oey aeica ua ia aeeeeea? iae?ioe/ieo ci?i a i?aaiao, ia i?ecaiaeeoue aei caaeaae? oaa?ei. AIE-68 ia i?iyaey? eoioeyoeaii? ae??, ia aeeeeea? o?iiiniiieo aaa?aoe?e ia ee?oeiao e?noeiaiai iiceo ieoae. AENIIAEE 1. Aia?oa anoaiiaeaii, ui 2,2-ae?ai?iiaeeoai?ee caeaoi? i?iyaeyoe ae?aaeaio i?ioea?eoi?/io ae?th. Aeine?aeaeoaai? iio?aei? aeeaaiciae?acai?io ye i?ioea?eoi?ee aeyaeeenue iaeiaeoeaieie. 2. Iaea?eueo neeueio i?ioea?eoi?/io ae?th na?aae ae?ai?iiaeeoai?e?a i?iyaey? niieoea i?ae eaai?aoi?iei oeo?ii AIE-68. Aiia a 100% aeine?ae?a eoi??o? aeii?oeiiao a?eoi?th a i?i?iaeuei?e aeic?, yea noaiiaeoue eeoa 1% a?ae EAe50. ?? i?ioea?eoi?/iee ?iaeaen aei??aith? 48. Ca i?ioea?eoi?/iith aeoeai?noth niieoea cia/ii ia?aaaaea? ae?th: ei?aea?iio, e?aeiea?io ? iiaiea?iai?aeo. 3. Niieoea AIE-68 a aeic? 10 ia/ea a 100% aeine?ae?a a?aeiiaeth? neioniaee ?eoi i?e oei?eaeaa???a?e a?eoi??, ia?aaa?ooth/e ae?th ei?aea?iio ? e?aeiea?io, i?iyaey? i?ioea?eoi?/io ae?th ia no?ioaioeiia?e iiaeae? a?eoi??. A aeic? 30 ia/ea i?iyaey? aeoeai?noue ia oei?eaeeaeueoe??a?e iiaeae? a?eoi??. 4. O AIE-68 aeyaeaia ae?aaeaia i?ioeo?a?eeyoi?ia ae?y. Ia iiaeae? iino?oai?/ii? ?aia?ooc?eii? a?eoi?? aiia iiia?aaeaeo? ?icaeoie o?a?eeyoe?? oeoii/e?a a 70,012,71% aeine?ae?a, a oie /an, ye ei?aea?ii aoaeoeaai a 50,016,6%, a e?aeiea?i a 60,017,3%. AIE-68 ca?eueoo? ii??a o?a?eeyoe?? oeoii/e?a ye ?ioaeoiiai i?iea?aeo, oae ? ia oii? ?caae?eiiaiai o?aaeaiiy. 5. Niieoea AIE-68 i?iyaey? aioea?iiene/io ae?th ii a?aeiioaiith aei na?oey, iiaeiaaeoth/e /an aeaeo?io?c?ieia?/ii? aeoeaiino? na?oey a aeine?aeao c ia?aoeneaiiyi o?aoa?. iie?auo? iiceiaee e?iaiia?a, ca?eueooth/e e?euee?noue oaa?ei, ye? aeaeeee a oiiaao a?iien?? iiceo, aeeeeeaii? ia?aa'yceith iaio caaaeueieo niiieo a?oa??e. 6. O AIE-68 aeyaeaia i?ioenoaeiiia ae?y, ui i?e??aith?oueny aei oaiiaa?a?oaeo, ? i?noeaaiaianoacoth/a ae?y, yea ni?anoaaey?oueny c iiaiea?iii. 7. AIE-68 iaeaaeeoue aei a?oie iaeioiene/ieo niieoe. A aeicao 1,25-2,5% EAe50 niieoea aeia?a ia?aiineoueny uo?aie i?e aioo??oiueii/a?aaeiiiio aaaaeaii? ia i?ioyc? 1 i?nyoey, ia aieeaa? ia a?noino?oeoo?o aioo??oi?o i?aai?a. Aiia ia ae?? ia nenoaio cai?oaiiy e?ia?, a aeic? 10% a?ae EAe50 ia i?iyaey? iooaaaiii? aeoeaiino? ia ee?oeie e?noeiaiai iiceo ieoae. 8. Niieoea AIE-68 ia?niaeoeaia aeey noai?aiiy a caaiaenueeeo oiiaao e?ea?nueei? oi?ie ? i?iaaaeaiiy oe?ieeo aeiee?i?/ieo aeine?aeaeaiue ?? a yeino? iioaioe?eiiai aenieiaoaeoeaiiai i?ioea?eoi?/iiai caniao. NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Aeaieeue/oe ?.A. Iiooe i?ioea?eoi?/ieo cania?a na?aae iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io // E?ee.- 1997.- ? 6.- N. 79 - 82. 2. Aeaieeue/oe ?.A. Oa?iaeieia?/i? aeanoeaino? iiai? iioaioe?eii? aioea?eoi?/ii? niieoee AIE-68 // E?ee.- 1998.- ? 3.- N.67 - 69. 3. Aeaieeue/oe ?.A., A?eo?i??ia A.A., Aeaieeue/oe A.A. Aeine?aeaeaiiy noao?ii?/ii? oiene/iino? niieoee AIE-68, yea i?iyaey? neeueio i?ioea?eoi?/io ae?th // E?ee.- 1998.- ? 5.- N.19.-.24. 4. Iao. 22175 A Oe?a?ia, IIE 6 N I7 D 243/04. I?ioea?eoi?/iee oa i?ioenoaei?iaeiee can?a / Noiey?/oe I.I., Aeaieeue/oe A.A., Aeaieeue/oe ?.A., Ia?oooia A.I., Ieaneooe?ia I.?.- ? 94096938; Cayae. 13.09.94; Iioae. 30.06.98; Io?oe. athe. ? 3.-N.3.1.134. 5. Noiey?/oe A.A., Aeaieeue/oe ?.A., Aeaieeue/oe A.A. E aii?ino ecuneaiey iiauo i?ioeaia?eoie/aneeo n?aaenoa // II Oe?a?inueea iaoeiaa eiioa?aioe?y c i?aeia?iaeiith o/anoth "Aeooaeuei? i?iaeaie oa?iaeieia??".- A?iieoey: I?eai-EOAe.- 1998.- N. 170 – 171. 6. Aeaieeue/oe ?.A. Iiaia i?ioeaia?eoie/aneia n?aaenoai / 60 ?ie?a Oe?a?inueeiio IAe? ?i. I.Ae. No?aaeanei. Iaoa??aee V eiia?ano ea?ae?ieia?a Oe?a?ie 12 - 14 o?aaiy 1997 ?.// Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.- 1996.- aeiaeaoie aei N 3.- N. 169. 7. Aeaieeue/oe ?.A., Aeaieeue/oe A.A. I?ioea?eoi?/ia aeoeai?noue aeayeeo iio?aeieo aeeaaiciae?acai?io ? ae?ai?iiaeeoai?eo // Iaoa??aee oa oace aeiiia?aeae II Iaoeiai-i?aeoe/ii? eiioa?aioe?? e?ea??a oa?eoi??aeueiiai iaaee/iiai ia'?aeiaiiy i?nueei? ee?i?/ii? e?ea?i? N4 (15-16 o?aaiy 1995 ?.) A?iieoey.- 1995.- N. 26 - 7. 8. Aeaieeue/oe ?.A., Noiey?/oe I.I., Aeaieeue/oe A.A. I?ioea?eoi?/i? aeanoeaino? aeayeeo iio?aeieo aeeaaiciae?acai?io ? ae?ai?iiaeeoai?eo / Iaoa??aee I iaoe?iiaeueiiai c'?caeo oa?iaeieia?a Oe?a?ie. No/ani? i?iaeaie oa?iaeieia??.- Ee?a.- 1995. - N. 14 - 15. 9. Aeaieeue/oe ?.A., Noiey?/oe I.I. Aioea?iiene/ia ae?y iioaioe?eiiai i?ioea?eoi?/iiai caniao AIE-68 / Aeooaeuei? i?iaeaie iaaeeoeeie. Iaoa??aee oa oace eiioa?aioe??, i?enay/aii? 50 - ??//th ooai?aiiy A?iieoeueeiai iaeaniiai aini?oaeth ?iaae?ae?a a?eie (17-18 ea?oiy 1996 ?.) A?iieoey-1996.- N. 37 - 38. Aeaieeue/oe ?.A. Iiooe aoaeoeaieo i?ioea?eoi?/ieo cania?a na?aae iiaeo iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noueth 14.03.05 - oa?iaeieiaey.- ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?y i?enay/aia aenia?eiaioaeueiei aeine?aeaeaiiyi i?ioea?eoi?/ii? aeoeaiino? 20 iiaeo iio?aeieo ae?ai?iiaeeoai?eo oa aeeaaiciae?acai?io. I?iaaaeai? aeine?aeaeaiiy aeicaieeee aia?oa aeyaeoe na?aae ae?ai?iiaeeoai?e?a niieoee, ui i?iyaeythoue i?ioea?eoi?/io aeoeai?noue. Aeyaeaii niieoeo AIE-68, yea a aeic?, ui neeaaea? eeoa 1% a?ae EAe50, a 100% aeine?ae?a eoi??o? aeii?oeiiao a?eoi?th. Ii nai?e aeoeaiino? aiia ia?aaa?oo? ae?th a?aeiieo i?ioea?eoi?/ieo cania?a ei?aea?iio, e?aeiea?io, iiaiea?iai?aeo ia aeii?oeiia?e ? oei?eaeaa???a?e iiaeaeyo ? i?e??aith?oueny aei ieo ia ?ioeo iiaeaeyo a?eoi?e. AIE-68 ia? oae? oe?ii? aeey aioea?eoi?ea aeanoeaino? ye aioea?iiene/io, i?ioeo?a?eeyoi?io, i?ioenoaeiiio, i?noeaaiaianoacoth/o, iie?auo? iiceiaee e?iaiia?a, ia aieeaa? ia nenoaio cn?aeaiiy e?ia?. Niieoea AIE-68 iaeaaeeoue aei a?oie iaeioiene/ieo niieoe, ia aeeeeea? o?iiiniiieo aaa?aoe?e a ee?oeiao e?noeiaiai iiceo ieoae. ?aeiiaiaeo?oueny noai?aiiy a caaiaenueeeo oiiaao e?ea?nueei? oi?ie niieoee AIE-68, i?iaaaeaiiy iiaeeaeaiiai aea/aiiy oa?iaeieia?/ieo ? oieneeieia?/ieo aeanoeainoae e?ea?nueei? oi?ie a yeino? iioaioe?eiiai aenieiaoaeoeaiiai i?ioea?eoi?/iiai caniao. Eeth/ia? neiaa: ae?ai?iiaeeoai?e, aeeaaiciae?acai?i, i?ioea?eoi?/ia ae?y. aioea?iiene/ia ae?y, i?ioeo?a?eeyoi?ia ae?y, i?ioenoaeiiia ae?y, i?noeaaiaianoacoth/a ae?y, iiceiaee e?iaiia?a. Aeaieeue/oe E.A. Iiene yooaeoeaiuo i?ioeaia?eoie/aneeo n?aaenoa n?aaee iiauo i?iecaiaeiuo aeeaieiiaeeoaieea e aeeaaiciaeeacaieia.-?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.05 - oa?iaeieiaey. - Einoeooo oa?iaeieiaee e oieneeieiaee AII Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia yenia?eiaioaeueiui enneaaeiaaieyi i?ioeaia?eoie/aneie aeoeaiinoe iiauo i?iecaiaeiuo aeeaieiiaeeoaieea e aeeaaiciaeeacaieia. Ino?ay oiene/iinoue enneaaeoaiuo niaaeeiaiee a iiuoao ia iuoao eieaaaeanue io 290 aei 428 ia/ea. Oiene/iinoue iaeaieaa aeoeaiiai niaaeeiaiey AIE-68 i?e aioo?ea?thoeiiii aaaaeaiee ia iuoao ninoaaeea 377,0 296,6:478,8 ia/ea, a ia aaeuo e?unao i?e aioo?eaaiiii aaaaeaiee 120,0 100,0:144,0 ia/ea. N?aaee enneaaeiaaaoeony 20 niaaeeiaiee 8 auee iaeiaeoeaiuie. A iniiaiii yoi i?iecaiaeiua aeeaaiciaeeacaieia. Cia/eoaeueii aieueooth aeoeaiinoue i?iyaeee i?iecaiaeiua aeeaieiiaeeoaieea. Niaaeeiaiey AIE-68, AIE-35, AIE-30, AIE-32, AO-14, AI-66, AIE-92 a aeicao, eioi?ua niioaaonoaotho 5% io EAe50, eoie?iaaee aeiieoeiiaoth a?eoieth a 100% iiuoia. Ianeieueei iaiueoee yooaeo i?iyaeee niaaeeiaiey AIE-69, AI-65, AIE-27, AO-13 ? AIE-64. Iaeaieaa aeoeaiui ieacaeinue niaaeeiaiea n eaai?aoi?iui oeo?ii AIE-68. Aeaaea a aeica 1 ia/ea (iaiueoa 1% io EAe50), iii a 100% iiuoia ia e?unao eoie?iaaei ia 2,10,51 ieioo aeiieoeiiaoth a?eoieth. N oaaee/aieai aeicu aei 19 ia/ea i?iaeieaeeoaeueiinoue i?ioeaia?eoie/aneiai aeaenoaey aic?anoaea aei 34,08,12 ieioo. N?aaeiyy aooaeoeaiay aeica (AAe50) yoiai niaaeeiaiey, ii?iaeecothuay ia?ooaiiue aeiieoeiii ?eoi na?aeoea ia ia?eiae aieaa 5 ieioo, ninoaaeea 2,5 [0,966,50] ia/ea, /oi ninoaaeyao 2% io EAe50 aeey e?un. I?ioeaia?eoie/aneee eiaeaen AIE-68 ?aaiyaony 48. Ii i?ioeaia?eoie/aneie aeoeaiinoe ia aeiieoeiiaie iiaeaee a?eoiee niaaeeiaiea AIE-68 cia/eoaeueii i?aauoaao ei?aea?ii (10 ia/ea) e eeaeieaei (10 ia/ea), eioi?ua a 3 iiuoao ec 10 (30,012,71%), e iiaieaeiaieae (20 ia/ea), eioi?ue a 4 iiuoao ec 10 (40,013,58%), oieueei e?aoeia?aiaiii ainoaiaaeeaaee ia?ooaiue aeiieoeiii ?eoi na?aeoea. Niaaeeiaiea AIE-68 a aeica 19 ia/ea, aaaaeaiiia ca 2-5 ieioo aei aeiieoeia, caaea?aeeaaei ?acaeoea aeiieoeiiaie a?eoiee a n?aaeiai ia 10 ieioo, oiaaea eae a eiio?ieueiuo enneaaeiaaieyo a?eoiey ?acaeaaeanue ia 1-4 ieiooa. Oaaee/aiea aeicu niaaeeiaiey aei 40 ia/ea ioaeaeyei ?acaeoea a?eoiee a n?aaeiai ia 22 ieioou, i?e yoii a 2 neo/ayo ec 5 a?eoiey ia aicieeea. I?aaeaa?eoaeueiia aioo?eaaiiia aaaaeaiea AIE-68 a aeica 30 ia/ea, i?aaeoi?aaeaeaei ?acaeoea oei?eaeeaeueoeeaaie a?eoiee a 71,414,3% neo/aaa. AIE-68 (10 ia/ea) a 1009,93% iiuoia ainnoaiaaeeaaei neioniaue ?eoi na?aeoea i?e oei?eaeaa?eaaie a?eoiee o e?ieeeia. Ei?aea?ii (5 ia/ea) e eeaeieaei (10 ia/ea) eoie?iaaee aa a 6 iiuoao ec 10 (60,013,59%). Niaaeeiaiea AIE-68 a aeica 10 ia/ea ainoaiaaeeaaei ia?ooaiiue no?ioaioeiii ?eoi na?aeoea ia 14-24 ieioou a 4 neo/ayo ec 7, oi anoue a 57,015,66% neo/aaa. A eiio?ieueiuo enneaaeiaaieyo iinoeoaie/aneay ?aia?ooceiiiay oea?eeeyoeey aeaeoaei/eia aicieeaea a 8 iiuoao ec 10 (80,0±12,65%). AIE-68 (10 ia/ea) i?aaeoi?aaeaeaei (?0,05) ?acaeoea iino?aia?ooceiiiie oea?eeeyoeee aeaeoaei/eia o eioae a 7 iiuoao ec 10 (70,012,71%). Ei?aea?ii (5 ia/ea) aue yooaeoeaai a 50,016,6% iiuoia, eeaeieaei (10 ia/ea) - a 60,017,3% iiuoia. Niaaeeiaiea AIE-68 (10 ia/ea) e?aoeia?aiaiii iiauoae ii?ia oea?eeeyoeee aeaeoaei/eia na?aeoea o e?un n 2,870,26 aei 4,130,40 A, oaaee/eaay aai ia 43% (?0,05). Aaaaeaiea niaaeeiaiey AIE-68 ia oiia ecaae?eiiaiai ii?aaeaiey ieiea?aea oaaee/eaaei (?0,01) ii?ia oea?eeeyoeee aeaeoaei/eia n 1,900,15 aei 3,900,64 A (ia 105,3%). Acyoue aeey n?aaiaiey eeaeieaei a aeica 10 ia/ea iiauoae (?0,01) nieaeaiue ecaae?eiii ii?ia oea?eeeyoeee aeaeoaei/eia n 2,930,37 aei 7,210,83 A (ia 146%). AIE-68 a aeica 10 ia/ea aeinoiaa?ii (?0,05) oiaiueoaao /anoioo na?aea/iuo nie?auaiee n ia/aeueiuo 188,013,15 aei 143,10,28 (ia 23,9%) e oaaee/eaaao (?0,05) a?aiy ainoaiiaeaiey ooieoeee neioniaiai ocea n 0,380,024 aei 0,490,044 (ia 28,9%). Niaaeeiaiea i?iyaeyao ianoiiaianoace?othuaa aeaenoaea, n?aaieiia n iiaieaeiii, aioeaeiiene/aneia, i?ioeainoaei?iaeiia aeaenoaea, i?aainoiaeyuaa oaiiaa?aeoae, iiauoaao iicaiaia e?iaiia?auaiea, ia aeeyao ia naa?ouaathuoth nenoaio e?iae. AIE-68 ioiineony e a?oiia iaeioiene/iuo aauanoa. A aeicao 5 e 10 ia/ea niaaeeiaiea oi?ioi ia?aiineony e?unaie e iuoaie i?e aioo?ea?thoeiiii aaaaeaiee ia i?ioyaeaiee 1 ianyoea, ia ieacuaay nouanoaaiiiai aeeyiey ia e?iaue, ooieoeee OeIN, ia/aie, ii/ae, aenoino?oeoo?o aioo?aiieo i?aaiia. Iii ia eoioee?oao, ia aucuaaao o?iiiniiiuo aaa??aoeee ia eeaoeao einoiiai iicaa iuoae. ?aeiiaiaeoaony nicaeaiea a caaiaeneeo oneiaeyo eaea?noaaiiie oi?iu AIE-68, i?iaaaeaiea aa oa?iaeieiae/aneeo e oieneeieiae/aneeo enneaaeiaaiee a ea/anoaa iioaioeeaeueiiai aunieiyooaeoeaiiai i?ioeaia?eoiu/aneiai. Eeth/aaua neiaa: aeeaieiiaeeoaiee, aeeaaiciaeeacaiei, i?ioeaia?eoie/aneia aeaenoaea. aioeaeiiene/aneia aeaenoaea, i?ioeaioea?eeeyoi?iia aeaenoaea, i?ioeainoaei?iaeiia aeaenoaea, ianoiiaianoace?othuaa aeaenoaea, iicaiaia e?iaiia?auaiea. Danilchuk I.V. In quest of effective antiarrhythmic drugs amon the derivatives of diaminodiphenil and dibenzodiazepin.-Manuscript. Dissertation for the prezentation for the candidate of medical science degree in specialization 14.03.05 - pharmacology. Institute of pharmacology and toxicology AMS of Ukraine, Kiev, 1999. Dissertation is based on the experimental research of antiarrhythmic effect of 20 new derivatives of diaminodiphenil and dibenzodiazepin. Conducted researchs revealed a new group of chemical combination (diaminodiphenil), those having antiarrhythmic effect. Experimentally in 100% cases, it is proved that combination AIE-68 in a dose of 1% LD50 arrested aconitic arrtythmia. These drugs are more effective then any other antiarrhythmic drugs like cordaronum, novocainamidum, lidocainum. AIE-68 also shows antihypoxic, antifibrillation, antiepileptic and local anaesthetic effect. They increase cranial blood circulation, without affecting coagulation system of blood. They are less toxic, dont have any mutagenic effect on bone-marrow cells of mice. So it is reccomended to prepare drug forms of AIE-68, to conduct further pharmacological and toxicological researchs - in purpose of futher clinical studies about antiarrhythmic effect of AIE-68. Key words: diaminodiphenil, dibenzodiazepin, antiarrhythmic effect, antifibrillation effect, antiepileptic effect, local anaesthetic effect, antihypoxic effect, cranial blood circulation.

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