Aeaaeai?y Iaaee/ieo Iaoe Oe?a?ie

?inoeooo ea?ae?ieia?? ?i. aeaae. I. Ae. No?aaeanea

Aoiueeiaa Aaeeia A?eoi??aia

OAeE: 616.12-008.46-036.12-085

Ii??aiyiiy ee?i?ei-oa?iaeiaeeiai?/ieo aoaeo?a ?ai?i?eea, oic?iii?eea oa
aiaeai?eea o oai?eo ?c o?ii?/iith na?oeaaith iaaeinoaoi?noth

14.01.11.-ea?ae?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a -1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? ea?ae?ieia?? ?i. aeaae.

I. Ae. No?aaeanea AII Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Ai?iieia Eaii?ae Aai?a?eiae/,
caa?aeoaa/ a?aeae?eaiiy na?oeaai? iaaeinoaoiino? ?inoeoooo ea?ae?ieia??
?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Aaiaeao sseia Aa?aiiae/, aieiaiee
iaoeiaee ni?a?ia?oiee a?aeae?eo caeiaooeo aaae na?oey ?inoeoooo
na?oeaai-noaeeiii? o??o?a?? AII Oe?a?ie.

aeieoi? iaaee/ieo iaoe A?eoi?ia Ieaen?e Iaaeiae/, caa?aeoaa/
a?aeae?eaiiy ee?i?/ii? oa?iaeieia?? ?inoeoooo ea?ae?ieia?? ?i. aeaae.
I.Ae.No?aaeanea AII Oe?a?ie.

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC
Oe?a?ie, eaoaae?a oaeoeueoaonueei? oa?ai?? c eo?nii aiaeie?eiieia??.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 25 o?aaiy i 12-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae. 26.616.01 i?e ?inoeooo?
ea?ae?ieia?? ?i. aeaae. I.Ae. No?aaeanea (252151, i. Ee?a, aoe.
Ia?iaeiiai Iiie/aiiy, 5).

C aeena?oaoe??th iiaeia iciaeiieoenue a iaoeia?e a?ae?ioaoe? ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae. No?aaeanea (252151,

i. Ee?a, aoe. Ia?iaeiiai Iiie/aiiy, 5)

Aaoi?aoa?ao ?ic?neaiee “ 22 ” ea?oiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee Aeaye N. ?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Canoinoaaiiy ?ia?a?oi??a
aia?ioaicei-ia?aoai?thth/iai oa?iaioo (?AIO) aeey e?eoaaiiy ONI ?
a?aeiinii iiaei iai?yieii no/anii? ea?ae?ieia??, ii/aoie yeiio
iieeaaeaii a?eueo 10 ?ie?a oiio. Ia i?aenoaa? aeina?aeo aaaaoioeaio?iaeo
aeine?aeaeaiue ?AIO, aei aeiaaaeaieo aoaeo?a oeueiai eeano i?aia?ao?a o
oaeeo oai?eo a?aeiinyoue ia o?eueee ee?i?ei-ooieoe?iiaeueia iie?auaiiy
?o noaio, aea e iie?auaiiy ?o aeaeeaaiiy (CONSENSUS, 1987, the SOLVD
Inv. 1992).

A inoaii? ?iee a ee?i?/io i?aeoeeo ai?iaaaeaeothoueny iia? ?AIO,
cie?aia oae? ye ?ai?i?ee (?), oic?iii?ee (O). Aeei?enoaiiy oeeo
i?aia?ao?a a?aeia?aaeaii a iaiaaeai?e e?eueeino? ioae?eaoe?e, iaea?eueo
cia/iith na?aae yeeo ? aeine?aeaeaiiy aoaeoeaiino? ? i?ney ?ioa?eoo
i?iea?aea (AIRE, 1993).

? ? i?ii?aia?aoii, yeee i?noeoue ea?aieneeueio a?oio, c aenieei
ia??iaeii iai?aaeaaaeaiiy, ui ia?aaeuo? aiaeia?/iee iieaciee eaioii?eea
ia 85% oa aiaeai?eea (A) ia 17%, ? c aeoaea iecueeith eiinoaioith
aeennioe?aoe?? ?ciia?iiai eiiieaena aicei-?ia?a?oi? — 640 oa (Buning P.,
1987).

A inoaii? ?iee oaaao aeine?aeiee?a i?eaa?oa? oaaao O, yeee aeae?eaiee a
ie?aiee i?aeeean ?AIO. Aei neeaaeo oeueiai i?aia?aoo aoiaeeoue iieaeoea
oinoi?ii? eeneioe, ? eiai ae?i?iaoe?y ia caeaaeeoue a?ae a?eo, ie?eiai?
oa ia/?ieiai? iaaeinoaoiino? (Grover G.A.,, Sleph P.G., Dzwonszyk S. et
al,1991, Zusman R.M., 1991).

Aei oaia??oiueiai /ano i?aeoe/ii ia i?iaaaeai? ni?anoaaeaiiy
ee?i?ei-oa?iaeiaeeiai?/ieo aoaeo?a aeuaiaaaaeaieo ?AIO c oaeeie o
“aoaeiiiiai” ?ia?a?oi?a o?eaaei? ae?? — A. Iaaeinoaoiuei aea/ai? aeaye?
aniaeoe oa?iaeiaeeiai?ee ?AIO. Iayai?noue aioeieneaeaioieo aeanoeainoae
?AIO, ye? c oai?aoe/ieo iiceoe?e iiaeooue aooe neeaaeiaeie niia?eueiaiiy
oaiio i?ia?anoaaiiy na?oeaai? iaaeinoaoiino?, o iiaeo ?AIO ? oa O
niaoe?aeueii ia aea/aeiny. A?aenooi? i?aeoe/i? ?aeiiaiaeaoe?? uiaei
aeei?enoaiiy ? oa O o oai?eo ?c nenoie?/iith cano?eiith na?oeaaith
iaaeinoaoi?noth.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?eii? ?iaioe aeeiiaia o neeaae? iaoeiai-aeine?aeii? ?iaioe
a?aeae?e?a na?oeaai? iaaeinoaoiino? oa oai?ia i?iea?aeo ? aaae na?oey
?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae. No?aaeanea “?ic?iaeoe iia?
iaoiaaiaoe/ii iaa?oioiaai? iaoiaee e?eoaaiiy oai?eo ?c ONI ??ciiai
aaiaco”, 1995-98 ??. OAeE 616.12-008. 46-036.12-037-985 EI (?
aea?ae?aa?no?aoe?? 0196 E 005233).

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoa ?iaioe — ioe?iea
ee?i?ei-oa?iaeiaeeiai?/ieo aoaeo?a iiaeo ?AIO — ? ? O o oai?eo ?c ONI,
iaoiiaeaiith nenoie?/iith aeenooieoe??th e?aiai oeoii/ea, ?ic?iaea
?aeiiaiaeaoe?e uiaei ?oiueiai i?aeoe/iiai canoinoaaiiy.

I?ae /an aeeiiaiiiy ?iaioe ae??ooaaeenue oae? caaaeaiiy:

1. Aea/eoe a ii??aiyeueiiio ieai? aieea ?, O ? A ia
ee?i?ei-ooieoe?iiaeueiee noai ? o?ce/io i?aoeacaeaoi?noue oai?eo ?c ONI.

2. Ii??aiyoe aieea aeuacacia/aieo i?aia?ao?a ia iieacieee ooieoe??
e?aiai oeoii/ea ? aeaye? ia?aiao?e aaiiaeeiai?ee o oai?eo ?c o?ii?/iith
nenoie?/iith na?oeaaith iaaeinoaoi?noth.

3. Aecia/eoe aeeiai?eo aeiaiaiai ai?noo eaoaoieai?i?a o na/?, iieaciee?a
no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai a?eo?ioeeo?a, ia?aeeniiai
ieenethaaiiy e?i?ae?a (IIE), aeoeaiino? AIO o ne?iaaooe? e?ia? i?ae
aieeaii ?, O a c?noaaeaii? c A.

4. Ia i?aenoaa? ocaaaeueiaiiy io?eiaieo aeaieo iaa?oiooaaoe ? ?ic?iaeoe
?aeiiaiaeaoe?? ii canoinoaaiith ? ? O o oai?eo ?c ONI.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. A ?acoeueoao? i?iaaaeaiiai
aeine?aeaeaiiy aia?oa anoaiiaeaii:

— a?eueo ae?acia i?aeaeuaiiy o?ce/ii? i?aoeacaeaoiino? oa iie?auaiiy
aaiiaeeiai?/iiai caaacia/aiiy o?ce/iiai iaaaioaaeaiiy o oai?eo ?c ONI
i?ae aieeaii A a ii??aiyii? ?c O oa ?.

— a?eueo ae?aciee ni?eyoeeaee aieea O ia iieacieee nenoie?/ii? ooieoe??
e?aiai oeoii/ea ii??aiyiii c A oa ? o oai?eo ?c ONI;

— aioeieneaeaioio oa iioei?coth/o no?oeoo?ii-ooieoe?iiaeueiee noai
iaia?ai ae?th ?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

Iaa?oioiaaia iaiao?aei?noue canoinoaaiiy A aeey e?eoaaiiy oai?eo ?c ONI
??-??? ooieoe?iiaeueieo eean?a (OE) (a?aeiia?aeii aei e?eoa???a NYHA)
caaaeyee eiai a?eueo ae?aciiio ni?eyoeeaiio aieeao ia o?ce/io
i?aoeacaeaoi?noue ? aaiiaeeiai?/ia caaacia/aiiy o?ce/iiai iaaaioaaeaiiy
oaeeo oai?eo o ii??aiyii? ?c O ? ?.

Iaeneiaeueiee aieea ia ?aiiaeaethaaiiy EO o iaoe??io?a ?c ae?aaeaiith
aeenooieoe??th i?iea?aeo aa?oi i/?eoaaoe a?ae O a ii??aiyii? ?c A ? ?.

I?e eaai?aoi?ii aeiaaaeai?e aeoeaaoe?? i?ioean?a e?iiia?ieneaeaoe??
iaa?oioiaaia iaio?aei?noue i?ecia/aiiy oai?ei ?c ONI ? ye i?aia?aoo, ui
/eieoue aioeieneaeaioio ae?th ? iie?auo? no?oeoo?ii-ooieoe?iiaeueiee
noai ee?oeiieo iaia?ai.

Cai?iiiiiaai? ?aeiiaiaeaoe?? uiaei i?ecia/aiiy aea/aieo ?AIO oai?ei ?c
o?ii?/iith na?oeaaith iaaeinoaoi?noth cai?iaaaeaeai? a i?aeoeeo ?iaioe
iie?ee?i?/iiai a?aeae?eaiiy ?inoeoooo ea?ae?ieia?? ?i. aeaae.
I.Ae.No?aaeanea, ui i?aeoaa?aeaeo?oueny a?aeiia?aeiei aeoii i?i
ai?iaaaeaeaiiy. Aeniiaee ? ?acoeueoaoe ?iaioe aoee aeei?enoai? i?e
noai?aii? iaoiaee/ieo ?aeiiaiaeaoe?e ii e?eoaaiith oai?eo ?c
aeeeyoaoe?eiith ea?ae?ii?iiao??th.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a a io?eiai? ?acoeueoaoe ?
iniiaiei ? iieyaa? o aeai?? ia’?io oa iaoiae?a aeine?aeaeaiiy,
anoaiiaeaii? iaoe oa caaaeaiue, i?iaaaeaii? eo?aoe?? oa ee?i?/ieo
aeine?aeaeaiue oai?eo. Aaoi? iniaenoi aeeiioaaea aoiea?ae?ia?ao?th
(AOIEA) oa aaeia?aiiao??th (AAI), ioe?ieea io?eiai? ?acoeueoaoe, i?iaaea
ocaaaeueiaiiy oa noaoenoe/io ia?iaeo ?acoeueoao?a, i?aeaiooaaea iaoeia?
aeai? aei ioae?eaoe??, ioi?ieea aeena?oaoe?eio ?iaioo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aoee i?aaenoaaeai? ia iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei?
ieoaiiy ee?i?/ii? oa?iaeioa?ai??” (Oa?e?a, eenoiiaae 1996),
i?aenoieia?e nan?? ?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea
(Ee?a, ethoee 1999).

Ai?iaaoe?y aeena?oaoe?? a?aeaoeany 30 a?oaeiy 1998?.ia ni?eueiiio
can?aeaii? a?aeae?eaiue na?oeaai? iaaeinoaoiino? oa aaae na?oey ? oai?ia
i?iea?aeo ?inoeoooo ea?ae?ieia?? ?i. I.Ae. No?aaeanea.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii o?e aeo?iaeuei?
noaoo? o oaoiaeo aeaeaiiyo ? o?e oace.

No?oeoo?a aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio, 5
?icae?e?a, aeniiae?a oa nieneo e?oa?aoo?e, ui i?noeoue 161 aeaea?aeo.
Aeena?oaoe?eio ?iaioo aeeiiaii ia 112 noi??ieao iaoeiiieniiai oaenoo,
?ethno?iaaii 48 oaaeeoeyie oa 4 iaethieaie.

INIIAIEE CI?NO ?IAIOE

Ee?i?/ia oa?aeoa?enoeea oai?eo. Iniiao aeaii? ?iaioe noaiiaeyoue
?acoeueoaoe ianoaaeaiiy 88 oai?eo c o?aeoe??th aeeeaeo (OA)
e?aiai oeoii/ea (EO) <45%, na?aae yeeo ae?aaiic aeeeyoaoe?eii? ea?ae?ii?iiao?? anoaiiaeaiee o 59 iaoe??io?a, o 18 - ?oai?/ii? oai?iae na?oey oa a?ia?oii?/ii? oai?iae III no. (aeaeiiiainiaaiiai a?ia?oaiceaiiai na?oey) - o 11. A?oie ia a?ae??ciyeenue ca /anoioith cono??/a?iino? aeuaiaaaaeaieo iicieia?/ieo iaeeieoeue. A?e oai?eo neeaa a?ae 22 aei 70 ?ie?a, o na?aaeiueiio 47,14+0,56 ?ie?a. Ae?aaiic aacoaaany ia i?aenoaa? aeaieo aiaiiaco, ee?i?/ieo i?iya?a, YEA, ?aioaaiieia?/ieo ? eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy. A on?o oai?eo aoee iciaee cano?eii? na?oeaai? iaaeinoaoiino?, ?oi?e ooieoe?iiaeueiee noai a?aeiia?aeaa II-III ooieoe?iiaeueiei eeanai (OE) ii e?eoa??yo NYHA, ?c ieo II OE aoa ae?aaiinoiaaiee o 29 iaoe??io?a (33%), III - o 59 oai?eo (67%). O 70 oai?eo niinoa??aaeiny ii?ooaiiy ?eoio na?oey, i?e oeueiio a 42 iaoe??io?a (47,7%) a?aecia/aeany iino?eia, o 3 oai?eo (3,4%) - ia?ieneciaeueia oi?ie o?a??eyoe?? ia?aaena?aeue, o 24 (27,3%) - oeoii/eiaa aeno?anenoie?y. Ii?ooaiiy i?ia?aeiino? niinoa??aaeiny o 8 /ieia?e (9,1%). I?ney noaa?e?caoe?? ee?i?/iiai noaio i?ioyaii 7-10 aei?a ca aeiiiiiaith ae?o?aoeea (oo?inai?aea a aeic? 40-120 ia/noo), ae?aieneia 0,250-0,350 ia/noo i?e iayaiino? o?a??eyoe?? ia?aaena?aeue ? ei?aea?iia 200-300 ia/noo i?e iayaiino? oeoii/eiai? aeno?anenoie?? aei oa?ai?? i?aeeeth/aee iaeei ?c aeine?aeaeoaaieo ?AIO. Aeey caiia?aaiiy o?iiaaiaie?/ieo oneeaaeiaiue an? oai?? c iiiaioo anoaiiaeaiiy ae?aaiico ?aaoey?ii iaea?aeoaaee ani??ei o aeiaia?e aeic? 0,125 a. Eiio?ieuei? aeine?aeaeaiiy i?iaiaeeee i?ney noaa?e?caoe?? ee?i?/iiai noaio - ia?oee aoai, i?ney 2 oeaei?a i?eeiio ?AIO - ae?oaee ? i?ney 8 oeaei?a e?eoaaiiy - o?ao?e aoaie. O caeaaeiino? a?ae i?eeiio ??cieo ?AIO on? oai?? aoee ?iciiae?eai? ia o?e a?oie: ui i?eeiaee ? (i?aia?ao “Tritace” o??ie Hoechst, Aa?iai?y) - ? a?oia, O (i?aia?ao “Monopril”, o??ie A?enoieue-Iaea?n Neaeaa, NOA) - ?? ? A (“Renitec”, ae?iaieoeoai MSD, NOA) - ??? a?oie. A?oie aoee ii??aiyi? ca a?eii, OE, aaee/eiith aeo?aeii? o?aeoe?? aeeeaeo (OA) e?aiai oeoii/ea (EO) ? /anoioith cono??/a?iino? iino?eii? oi?ie o?a??eyoe?? ia?aaena?aeue (oaae.1). Oaaeeoey 1 Na?aaei?e a?e, OE, OA e?aiai oeoii/ea oai?eo ?c ONI A?oie oai?eoA?e, ?ie?a OE, oi. iae. OA, %?ai?i?ee45,53+2,232,67+0,1134,05+1,35oic?iii?ee50,78+2,623,06+0,1934,99 +1,33aiaeai?ee46,12+1,582,89+0,3332,27+1,29 I?ei?oea. An? a?aei?iiino? iieaciee?a i?ae a?oiaie ia aeinoia??i? (p>0,05).

E?eoaaiiy ?AIO ii/eiaee c iaeiie?aoieo ni?iaieo aeic: 1,25 ia aeey ?,
2,5 ia aeey O ? 2,5 aeey A ?c ianooiiei oeo?oaaiiyi aei iaeneiaeueii
ee?i?/ii noa?iii?. Na?aaei? aeiaia? aeice neeaee aeey ? — (4,44+0,28)
ia, O — (6,65+0,54) ia ? (4,82+0,18) ia aeey A.

I?aea?? iioeiaeueii? aeice i?aia?ao?a cae?enithaaany ia i?aenoaa?
?aeiiaiaeaoe?e o??i – ae?iaiee?a a?aeiia?aeieo ?AIO ? a?aeiia?aeaa
caaaeueiii?eeiyoei ?aeiiaiaeaoe?yi uiaei ?oiueiai ee?i?/iiai
aeei?enoaiiy.

Iaoiaee aeine?aeaeaiiy. Ii?yae c ?aoaeueiei ee?i?/iei ianoaaeaiiyi an?i
oai?ei i?iaiaeeee ?ino?oiaioaeuei? ? eaai?aoi?i? iaoiaee aeine?aeaeaiiy.
Ioe?ieo aioo??oiueina?oeaai? aaiiaeeiai?ee cae?enithaaee ca aeiiiiiaith
AoiEA a I- oa A-?aaeeiao ia aia?aoao “Biomedica” (?oae?y) ca
caaaeueiii?eeiyoith iaoiaeeeith (O?eea? E., Ineiia I.A., 1993).

Ca aeiiiiiaith AoiEA ia/enethaaee e?ioeaai-nenoie?/iee ?ici?? EO,
e?ioeaai-ae?anoie?/iee ?ici?? EO, ia?aaeiuei-caaei?e ?ici?? e?aiai
ia?aaena?aey (EI). Io?eiai? ?ici??e ii?iaeieie EO aeei?enoiaoaaee aeey
?ic?aooieo oaeeo iieaciee?a, ye e?ioeaai-nenoie?/iee ia’?i (ENI) ?
e?ioeaai-ae?anoie?/iee ia’?i (EAeI) EO ii oi?ioe? L.Teicholtz.

O?aeoe?th aeeeaeo (OA) EO aecia/aee ii oi?ioe?:

OA=(EAeI-ENI)/EAeIo100%, (1)

aea

OA – o?aeoe?y aeeeaeo e?aiai oeoii/ea;

EAeI – e?ioeaai-nenoie?/iee ia’?i;

ENI — e?ioeaai-ae?anoie?/iee ia’?i.

Aecia/aiiy oiea?aioiino? aei o?ce/iiai iaaaioaaeaiiy i?iaiaeeee ca
aeiiiiiaith aaeia?aiiao?e/iiai oanoo ia aaeia?aiiao?? “Simens-Elema”
(I?ia//eia) o neaey/iio iieiaeaii?. Aeei?enoiaoaaany iaoiae
aacia?a?aii-c?inoath/iai iaaaioaaeaiiy. Ii/aoeiaa iiooaei?noue
iaaaioaaeaiiy anoaiiaethaaeanue ia 20 AO ? iio?i iiaoaiii ca?eueooaaeany
ia 20 AO. *an iaaeaethaaiiy eiaeiiai aoaio noaiiaea 4 oa. Oanooaaiiy
i?iaiaeeeiny aei aeinyaiaiiy noaiaeneiaeueii? /anoioe na?oeaaeo
nei?i/aiue (*NN) aai ae aei iiyae ae?aaeaii? caaeooe /e iioeo eeiii/ieo
iciae, ui e?i?ooaaee iiaeaeueoa i?iaeiaaeaiiy i?iae. I?ae /an
aeine?aeaeaiiy aecia/aeeny oae? iieacieee: nenoie?/iee a?oa??aeueiee
oene (AOn), *NN, iiaea?eiee aeiaooie (IAe) (aeiaooie *NN ia AOn) a noai?
niieith, ia ?aeaioe/iiio (?ae) ? ia ii?iaiaiio (ii??a) ??aiyo
iaaaioaaeaiiy, /an iaaeaethaaiiy a oaeeeiao (t). Ca aeaieie AAI oaeiae
aecia/aee iieacieee ianyao aeeiiaii? ?iaioe (A) oa aaiiaeeiai?/ii?
aa?oino? ?iaioe (AA?) ii oi?ioeai:

A=Wo6oTo9,81, (2)

aea

W – iiooaei?noue iaaaioaaeaiiy, yea aeeiioaaee iaoe??ioe i?ae /an
AAI-oanoo, a Ao;

t – o?eaae?noue aeeiiaiiy AAI oanoo a oa.,

AA?=IAeii??a-IAe o noai? niieith/A, (3)

 aea

IAeii??a – iiaea?eiee aeiaooie ia ii?iaiaiio iaaaioaaeaii? AAI-oanoo a
oi.iae.;

IAe — iiaea?eiee aeiaooie o noai? niieith a oi. iae.

A – caaaeueiee ianya aeeiiaii? ?iaioe, a eAeae.

Eaai?aoi?ia ianoaaeaiiy neeaaeaeiny ?c caaaeueiiee?i?/ieo, a?io?i?/ieo
(eiio?iethaaeenue ai?no aeaeo?ie?o?a (E+, Na+), ??aaiue e?aaoei?io
e?ia?) ? niaoe?aeueieo iaoiae?a aeine?aeaeaiiy. O eaai?aoi??? ee?i?/ii?
a?io?i?? OIAe? (ea??aiee i?io. E.N. Io?oa?yi) aecia/aeeny iieacieee IIE
ii iaoiaeo Noaeueii?, ooieoe?iiaeueiiai noaio iaia?ai a?eo?ioeeo?a ia
a?io?i?/iiio aiae?caoi?? Ciba Corning (Aiae?y), ??ai?a eaoaoieai?i?a o
aeiaia?e e?eueeino? na/? ii iaoiaeo Iaoe?ii?. Aeine?aeaeaiiy aeoeaiino?
AIO o ne?iaaooe? e?ia? i?iaaaeeeinue ca iaoiaeeeith Fridlend E. ia
oethi?eiao?? o??ie O?oa/?.

Ia oii? i?eeiio ?AIO o 7 oai?eo aeieeee iia?/i? aoaeoe, ui e?i?ooaaee
iiaeaeueoa e?eoaaiiy: i?e canoinoaaii? ? a 1 /ieia?ea (3,57%) — eaoaeue,
o 1 iaoe??ioa (3,57%) — a?eue a ae?eyioe? na?oey, o 1 oai?iai (3,57%)
a?aecia/aeiny i?aeaeuaiiy AO, i?e i?eeii? O — o 1 oai?iai (3,70%)
c’yaeeeny iai?e?ii? a?ae/oooy a ae?eyioe? na?oey, ui noi?iaiaeaeoaaeeny
oeoii/eiaith aeno?anenoie??th, i?e i?eeii? A — o 2 iaoe??io?a (6,06%)
ia?aaeuaiiy ii?iaeueii? eiioeaio?aoe?? e?aaoei?io a ieaci? e?ia? oa o 1
/ieia?ea (3,03%) — oe??ia aeneiea. Oe? oai?? ia aoee aeeth/ai? a
aeine?aeaeaiiy.

?acoeueoaoe aeine?aeaeaiue ia?iaeai? ca aeiiiiiaith iaoiae?a
aa??aoe?eii? noaoenoeee c aeei?enoaiiyi iaeaoa i?eeeaaeieo noaoenoe/ieo
i?ia?ai “Stat4win”. Ioe?iea a??ia?aeiino? ci?i iieaciee?a i?ae aieeaii
i?aia?ao?a a eiaei?e c a?oi cae?enithaaeany ca aeiiiiiaith iaoiaeo
niieo/aieo aa??aio (O?aao A.TH, 1975), a ioe?iea a??ia?aeiino?
a?aei?iiinoae aaniethoieo i?e?ino?a iieaciee?a i?ae ??cieie a?oiaie – ca
aeiiiiiaith iaoiaeo ii??aiyiiy na?aaei?o (O?aao A.TH, 1975).

?acoeueoaoe aeanieo aeineiaeaeaiue, ?o iaaiai?aiiy.

I?ecia/aiiy ?AIO ni?eyei aeinoia??iiio iie?auaiith iieaciee?a
aioo??oiueina?oeaai? aaiiaeeiai?ee. A on?o a?oiao oai?eo
a?aei?/aia aeinoia??ia ciaioaiiy ia?aaeiuei-caaeiueiai ?ici??o EI
i?ney 2 ? i?ney 8 oeaei?a aeine?aeaeaiiy. Aiae?c aaniethoieo aaee/ei
i?e?ino?a ?ici??o EI ca 8 oeaeiaaee ia??iae i?eeiio ?AIO o ii??aiyii? c
aeo?aeieie aaee/eiaie (DEI) iieacaa, ui inoaii?e i?ae aieeaii O
ciaiooaaany a a?eueo?e i???, i?ae i?ae aieeaii A ? ?, i?e/iio aeai?
?icoiaeaeaiiy aeinyaaee nooiaiy aeinoia??iino? noiniaii A (?<0,05). Aaee/eia DEI aeey ? neeaea (-0,29+0,08), aeey O - (-0,35+0,04), a aeey A – (-0,25+0,03) ni. E?eoaaiiy ?AIO ni?e/eiyei aeinoia??ia ciaioaiiy EAeI EO o?eueee a a?oiao oai?eo, ui iaea?aeoaaee A ? O. Ia a?aei?io a?ae ieo, o oai?eo, yeei aoa i?ecia/aiee ?, oeae iieaciee i?ae aieeaii e?eoaaiiy ia ci?ithaaany. O a?oi? iaoe??io?a, ui io?eioaaee e?eoaaiiy O, ciaioaiiy EAeI EO aoei a?eueo ae?aciei o ii??aiyii? c oai?eie, ui iaea?aeoaaee A oa ?, i?e/iio cacia/ai? a?aei?iiino? aeinyaaee nooiaiy a??ia?aeiino? noiniaii ? (?<0,05). Aaniethoia aaee/eia i?e?inoo EAeI EO ca 8 oeaeiaaee ia??iae i?eeiio ?AIO o ii??aiyii? c aeo?aeieie ?ici??aie (DEAeI) aeey ? noaiiaeea (-4,24+2,88), aeey A – (-12,07+4,94) ? aeey O - (-14,60+3,55) ie. Aeinoia??ia ciaioaiiy ENI EO i?ney 2 ? i?ney 8 oeaei?a e?eoaaiiy niinoa??aaeiny o an?o a?oiao oai?eo. Ciaioaiiy ENI i?ae aieeaii O aoei a??ia?aeii a?eueo ae?aciei (?<0,05), /ei i?ae aieeaii ? ? A. Aaniethoi? aaee/eie i?e?ino?a ENI EO ca 8 oeaeiaaee ia??iae i?eeiio ?AIO o ii??aiyii? c aeo?aeieie ?ici??aie (DECI) neeaee aeey ? (-16,29+1,70), aeey O – (24,20+3,50) ? aeey A (-15,58+2,00) ie (?en. 1). picscalex1000100090000036e0e00000c00130100000000050000000902000000000500 00000102ffffff000400000004010d000400000002010200050000000c02c400ab010300 00001e00040000002701ffff030000001e00040000002701ffff050000000b0200000000 030000001e00050000000102ffffff000500000009020000000015000000fb02f5ff0000 000000009001000000cc0000001254696d6573204e657720526f6d616e00cc0004000000 2d01000015000000fb02f5ff000000000000bc02000000cc0000001254696d6573204e65 7720526f6d616e00cc00040000002d010100040000002d01000010000000fb02f5ff0000 00000000bc02000000020000001253796d626f6c0002040000002d01020010000000fb02 f5ff000000000000bc02000000020000001253796d626f6c0002040000002d0103000400 00002d010200040000002d010100040000002d010200040000002d010100040000002d01 020004000000f001030010000000fb02f5ff000000000000bc0200000002000000125379 6d626f6c0002040000002d01030010000000fb021000070000000000bc02000000cc0102 022253797374656d00cc040000002d010400040000002701ffff030000001e0004000000 2d010300050000000102ffffff0005000000090200000000070000001604c400ab010000 000009000000fa02050000000000000000002200040000002d01050007000000fc020000 ffffff000000040000002d010600050000000902800080000400000004010d0004000000 02010200070000001b04c100a7010500050009000000fa02000000000000000000002200 040000002d010700040000002d010600040000002d010400040000002701ffff03000000 1e00040000002d010300040000002d010600040000002d010500050000000102ffffff00 05000000090280008000070000001604c400ab010000000007000000fc02010000000000 8020040000002d01080009000000fa02050000000000000000002200040000002d010900 04000000f0010500050000000902000000000400000004010d0004000000020102000e00 00002403050038001b004a011b004a01af003800af0038001b000700000015047e00a201 4500580109000000fa02000001000000000000002200040000002d01050004000000f001 09000500000014021b00380004000000020101000500000013021b004a01050000001302 af004a01050000001302af0038000500000013021b003800040000002d01070004000000 2d010600040000002d010400040000002701ffff030000001e00040000002d0103000400 00002d010800040000002d010500050000000102ffffff00050000000902000000000700 00001604c400ab0100000000040000002d010700040000002d010600040000002d010400 040000002701ffff030000001e00040000002d010300040000002d010800040000002d01 0500050000000102ffffff0005000000090200000000070000001604c000a70104000400 040000002d010700040000002d010600040000002d010400040000002701ffff03000000 1e00040000002d010300040000002d010800040000002d010500050000000102ffffff00 05000000090200000000070000001604b1004c011a003700040000002d01070004000000 2d010600040000002d010400040000002701ffff030000001e00040000002d0103000400 00002d010800040000002d010500050000000102ffffff00050000000902000000000700 00001604b2004d011a00370009000000fa02000001000000000000002200040000002d01 090004000000f001050007000000fc020000000000000000040000002d01050004000000 f0010800050000000102000000000400000004010d0004000000020102000e0000002403 05003b001b007a001b007a006b003b006b003b001b0009000000fa020000010000000000 00002200040000002d01080004000000f00109000800000026060f000600ffffffff0000 09000000fa02050000000000ffffff002200040000002d01090007000000fc0201000000 00000000040000002d010a000400000007010400050000000102ffffff00050000000902 000000003500000042010500000028000000080000000800000001000100000000002000 0000c40e0000c40e0000020000000200000000000000ffffff00f0f0f0f0f0f0f0f0f0f0 f0f0f0f0f0f00f0f0f0f0f0f0f0f0f0f0f0f0f0f0f0fc0c0c000c0c0c000c0c0c000c0c0 c000040000002d010b00040000002d010b00090000001d062100f00077003e001b008000 040000002d010b000500000009020100000005000000010201000000040000002d010a00 04000000f0010b00040000002d010800040000002d010500040000000701010008000000 26060f000600ffffffff010007000000fc020100000000008020040000002d010b000e00 00002403050080001b00be001b00be0092008000920080001b00040000002d0105000400 0000f0010b000800000026060f000600ffffffff0000040000002d010900040000002d01 0a000400000007010400050000000102ffffff0005000000090200000000350000004201 05000000280000000800000008000000010001000000000020000000c40e0000c40e0000 020000000200000000000000ffffff00ffffffffffffffffffffffff7ff7f7f7ffffffff fffffffffffffffff77f7f7fc0c0c000c0c0c000c0c0c000c0c0c000040000002d010b00 040000002d010b00090000001d062100f0004b003f001b00c400040000002d010b000500 000009020100000005000000010201000000040000002d010a0004000000f0010b000400 00002d010800040000002d01050004000000070101000800000026060f000600ffffffff 010007000000fc020100000000008020040000002d010b000e00000024030500c4001b00 03011b0003016600c4006600c4001b00040000002d01050004000000f0010b0004000000 2d010700040000002d010600040000002d010400040000002701ffff030000001e000400 00002d010300040000002d010500040000002d0108000500000001020000000005000000 090200000000070000001604b1004c011a003700040000002d010700040000002d010600 040000002d010400040000002701ffff030000001e00040000002d010300040000002d01 0500040000002d0108000500000001020000000005000000090200000000070000001604 c400ab010000000009000000fa02000003000000000000002200040000002d010b000400 0000f00108000500000014021b003800050000000102ffffff000400000004010d000400 000002010100050000001302af003800040000002d010100050000001402af0035000500 00001302af00380005000000140296003500050000001302960038000500000014027e00 35000500000013027e003800050000001402650035000500000013026500380005000000 14024c0035000500000013024c0038000500000014023400350005000000130234003800 0500000014021b0035000500000013021b0038000500000014021b003800050000001302 1b004a01040000002d0100000500000014021e0038000500000013021b00380005000000 14021e007d000500000013021b007d000500000014021e00c1000500000013021b00c100 0500000014021e0006010500000013021b0006010500000014021e004a01050000001302 1b004a01040000002d010700040000002d010600040000002d010400040000002701ffff 030000001e00040000002d010000040000002d010500040000002d010b00050000000102 ffffff0005000000090200000000070000001604c400ab0100000000040000002d010100 040000002d010700040000002d010600040000002d010400040000002701ffff03000000 1e00040000002d010100040000002d010500040000002d010b00050000000102ffffff00 05000000090200000000070000001604c500ac01ffffffff0400000004010d0004000000 020101000c000000320aa8002000030000002d3330000400060006000c000000320a8f00 2000030000002d3235000400060006000c000000320a77002000030000002d3230000400 060006000c000000320a5e002000030000002d3135000400060006000c000000320a4500 2000030000002d3130000400060006000a000000320a2d002600020000002d3504000600 09000000320a14002a000100000030000600040000002d010700040000002d0106000400 00002d010400040000002701ffff030000001e00040000002d010100040000002d010500 040000002d010b00050000000102ffffff0005000000090200000000070000001604c400 ab0100000000040000002d010000040000002d010700040000002d010600040000002d01 0400040000002701ffff030000001e00040000002d010000040000002d01050004000000 2d010b00050000000102ffffff0005000000090200000000070000001604c500ac01ffff ffff040000002d010700040000002d010600040000002d010400040000002701ffff0300 00001e00040000002d010000040000002d010500040000002d010b00050000000102ffff ff0005000000090200000000070000001604c400ab0100000000040000002d0102000400 0000f001030010000000fb02f5ff000000000000bc02000000020000001253796d626f6c 0002040000002d010300040000002d010200040000002d010100040000002d0102000400 00002d010100040000002d01020004000000f001030010000000fb02f5ff000000000000 bc02000000020000001253796d626f6c0002040000002d010300040000002d0107000400 00002d010600040000002d010400040000002701ffff030000001e00040000002d010300 040000002d010500040000002d010b00050000000102ffffff0005000000090200000000 07000000160484001f0047000b00040000002d010200040000002d010100040000002d01 02000400000004010d000400000002010100040000002d01050013010000410bc6008800 0a000d00000000000a000d0077000e00280000000e0000000b0000000100180000000000 0000000000000000000000000000000000000000ffffffffffffffffffffffffffffffff ffffffffffffffffffffffffffffffffffffffffffffffffffffff00ffffffffffffffff ffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff00 ffffffffffffffffffffffffffffffffffffffffffffffffffffff000000000000ffffff ffffffffffffff00ffffffffffffffffffffffffffffffffffff00000000000000000000 0000000000ffffffffffffffffffff00ffffffffffffffffffffffff0000000000000000 00000000000000ffffff000000ffffffffffffffffffff00ffffffffffff000000000000 000000000000ffffffffffffffffffffffff000000ffffffffffffffffffff00ffffffff ffff000000000000000000000000ffffffffffffffffffffffff000000ffffffffffffff ffffff00ffffffffffffffffffffffff000000000000000000000000000000ffffff0000 00ffffffffffffffffffff00ffffffffffffffffffffffffffffffffffff000000000000 000000000000000000ffffffffffffffffffff00ffffffffffffffffffffffffffffffff ffffffffffffffffffffff000000000000ffffffffffffffffffff00ffffffffffffffff ffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff00 13010000410b090bba000a000d00000000000a000d0077000e00280000000e0000000b00 000001001800000000000000000000000000000000000000000000000000ffffffffffff ffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff ff00ffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff ffffffffffffffffff00ffffffffffffffffffffffffffffffffffffffffffffffffffff ff000000000000ffffffffffffffffffff00ffffffffffffffffffffffffffffffffffff 000000000000000000000000000000ffffffffffffffffffff00ffffffffffffffffffff ffff000000000000000000000000000000ffffff000000ffffffffffffffffffff00ffff ffffffff000000000000000000000000ffffffffffffffffffffffff000000ffffffffff ffffffffff00ffffffffffff000000000000000000000000ffffffffffffffffffffffff 000000ffffffffffffffffffff00ffffffffffffffffffffffff00000000000000000000 0000000000ffffff000000ffffffffffffffffffff00ffffffffffffffffffffffffffff ffffffff000000000000000000000000000000ffffffffffffffffffff00ffffffffffff ffffffffffffffffffffffffffffffffffffffffff000000000000ffffffffffffffffff ff00ffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffff ffffffffffffffffff00040000002d010500040000002d01010015000000fb02f5ff0000 84038403bc02000000cc0010001254696d6573204e657720526f6d616e00cc0004000000 2d0108000a000000320a77000e0006000000cad1ce2ceceb040000002d01010004000000 f0010800040000002d01020004000000f001030010000000fb02f5ff000000000000bc02 000000020000001253796d626f6c0002040000002d010300040000002d01070004000000 2d010600040000002d010400040000002701ffff030000001e00040000002d0103000400 00002d010500040000002d010b00050000000102ffffff00050000000902000000000700 00001604c400ab0100000000040000002d01000009000000fa0200000100000000000000 2200040000002d01080004000000f0010b00040000002d0106000400000004010d000400 000002010200070000001b047f00a20145005801040000002d010700040000002d010600 040000002d010400040000002701ffff030000001e00040000002d010000040000002d01 0600040000002d010800050000000102ffffff0005000000090200000000070000001604 7e00a20145005801040000002d010700040000002d010600040000002d01040004000000 2701ffff030000001e00040000002d010000040000002d010600040000002d0108000500 00000102ffffff00050000000902000000000700000016047e00a2014500580109000000 fa02000001000000000000002200040000002d010b0004000000f0010800080000002606 0f000600ffffffff0000040000002d010900040000002d010a0004000000070104000500 00000102ffffff0005000000090200000000350000004201050000002800000008000000 08000000010001000000000020000000c40e0000c40e0000020000000200000000000000 ffffff000880808000000000000000000000000080080808000000000000000000000000 ffffff00ffffffffffffffffffffffff040000002d010800040000002d01080009000000 1d062100f000060006004c005c01040000002d0108000500000009020100000005000000 010201000000040000002d010a0004000000f0010800040000002d010b00040000002d01 060004000000070101000800000026060f000600ffffffff010007000000fc0201000000 00008020040000002d010800050000000102000000000400000004010d00040000000201 0200070000001b04530063014c005c01040000002d01060004000000f001080005000000 0102ffffff000400000002010100040000002e0118000b000000320a5300660108000000 d0e0ecb3eff0e8eb040000002e010000040000002d010700040000002d01060004000000 2d010400040000002701ffff030000001e00040000002d010000040000002d0106000400 00002d010b00050000000102ffffff00050000000902000000000700000016047e00a201 45005801040000002d010700040000002d010600040000002d010400040000002701ffff 030000001e00040000002d010000040000002d010600040000002d010b00050000000102 ffffff00050000000902000000000700000016047e00a2014500580109000000fa020000 01000000000000002200040000002d01080004000000f0010b000800000026060f000600 ffffffff0000040000002d010900040000002d010a000400000007010400050000000102 ffffff000500000009020000000035000000420105000000280000000800000008000000 010001000000000020000000c40e0000c40e0000020000000200000000000000ffffff00 0ff0f0f00ff0f0f00ff0f0f00ff0f0f0f00f0f0ff00f0f0ff00f0f0ff00f0f0f00000000 ffffff00ffffff00ffffff00040000002d010b00040000002d010b00090000001d062100 f000060006005f005c01040000002d010b00050000000902010000000500000001020100 0000040000002d010a0004000000f0010b00040000002d010800040000002d0106000400 0000070101000800000026060f000600ffffffff010007000000fc020100000000008020 040000002d010b00050000000102000000000400000004010d0004000000020102000700 00001b04660063015f005c01040000002d01060004000000f0010b00050000000102ffff ff000400000002010100040000002e0118000c000000320a660066010a000000d4eee7b3 edeeeff0e8eb040000002e010000040000002d010700040000002d010600040000002d01 0400040000002701ffff030000001e00040000002d010000040000002d01060004000000 2d010800050000000102ffffff00050000000902000000000700000016047e00a2014500 5801040000002d010700040000002d010600040000002d010400040000002701ffff0300 00001e00040000002d010000040000002d010600040000002d010800050000000102ffff ff00050000000902000000000700000016047e00a2014500580109000000fa0200000100 0000000000002200040000002d010b0004000000f00108000800000026060f000600ffff ffff0000040000002d010900040000002d010a000400000007010400050000000102ffff ff0005000000090200000000350000004201050000002800000008000000080000000100 01000000000020000000c40e0000c40e0000020000000200000000000000ffffff00ffff ffffffffffffffffffff7ff7f7f7fffffffffffffffffffffffff77f7f7fffffff00ffff ff00ffffff00ffffff00040000002d010800040000002d010800090000001d062100f000 0600060072005c01040000002d0108000500000009020100000005000000010201000000 040000002d010a0004000000f0010800040000002d010b00040000002d01060004000000 070101000800000026060f000600ffffffff010007000000fc0201000000000080200400 00002d010800050000000102000000000400000004010d00040000000201020007000000 1b047900630172005c01040000002d01060004000000f0010800050000000102ffffff00 0400000002010100040000002e0118000c000000320a7900660109000000c5ede0ebe0ef f0e8eb00040000002e010000040000002d010700040000002d010600040000002d010400 040000002701ffff030000001e00040000002d010000040000002d010600040000002d01 0b00050000000102ffffff00050000000902000000000700000016047e00a20145005801 040000002d010700040000002d010600040000002d010400040000002701ffff03000000 1e00040000002d010000040000002d010600040000002d010b00050000000102ffffff00 05000000090200000000070000001604c400ab0100000000040000002d01050004000000 2d01070004000000f0010b00040000002701ffff050000000c02c400ab01030000001e00 050000000102ffffff0005000000090200000000040000002701ffff050000000b020000 0000030000001e00050000000102ffffff000500000009020000000004000000f0010300 040000002701ffff030000000000 ?en.1 Aaniethoi? ?ici??e i?e?ino?a ENI EO ca ainueieoeaeiaaee ia??iae e?eoaaiiy (DENI) ??cieie ?ia?a?oi?aie AIO. I?ei?oea. * - a?aei?ii?noue iieacieea ? a??ia?aeiith o ii??aiyii? c aeaiia ?ioeie a?oiaie. OA EO a??ia?aeii ca?eueooaaeany o an?o o?ueio a?oiao. Ae?aci?noue ca?eueoaiiy OA EAE aei e?ioey 8 oeaei? i?eeiio i?aia?ao?a i?ae a?oiaie a??ia?aeii ia ??cieeany. Aiae?c iieaciee?a aaiiaeeiai?ee o noai? niieith iieacaa, ui e?eoaaiiy ?AIO ni?eyei ai?iaiaeiiio cieaeaiith IAe ia ae?oaiio aoai? aeine?aeaeaiiy o?eueee o iaoe??io?a, ui iaea?aeoaaee A, a?ae 97,28+3,90 i?e ii/aoeiaiio aeine?aeaeaii? aei 84,13+2,98 oi. iae., (p<0,05). O?aaa cacia/eoe, ui ci?ia IAe a?aeaoaaeany ye ca ?aooiie cieaeaiiy *NN, oae ? AOn. Aeuaaeacaia ci?ia oeueiai iieacieea a oai?eo, ui iaea?aeoaaee A, caa??aaeany ? i?ney 8 oeaei?a e?eoaaiiy: aaee/eia IAe ia oeueiio aoai? noaiiaeea 87,79+3,0 oi. iae. (ca ?aooiie aeinoia??iiai cieaeaiiy *NN). Aiae?c io?eiaieo aeaieo iieacaa, ui i?ecia/aiiy eiaeiiai ?c aea/aieo ?AIO ni?eya aeinoia??iiio iie?ioaiith ee?i?ei-ooieoe?iiaeueiiai noaio oai?eo. A on?o a?oiao i?ney e?eoaaiiy niinoa??aaeiny aeinoia??ia cieaeaiiy OE ia an?o aoaiao aeine?aeaeaiiy: a?ae 2,67+0,11, 3,06+0,19, 2,89+0,33 i?e ii/aoeiaiio ianoaaeai? aei 2,14+0,14, 2,56+0,16, 2,00+0,20 i?ney 2 oeaei?a e?eoaaiiy (p<0,05), ? aei 1,95+0,13, 2,33+0,23, 1,89+0,23 oi. iae. (p<0,05) i?ney 8 oeaei?a i?eeiio ?, O oa A, a?aeiia?aeii. Ca aeaieie AAI a?aecia/aeiny iinooiiaa i?aeaeuaiiy oiea?aioiino? aei o?ce/iiai iaaaioaaeaiiy (OOI) ia ae?oaiio ? o?aoueiio aoaiao aeine?aeaeaiiy o an?o a?oiao. Oae, caaaeueiee ianya A a??ia?aeii ca?eueooaaany i?ae aieeaii on?o o?ueio ?AIO. Ianya A, yeee aeeiiaee oai??, ui iaea?aeoaaee A, a??ia?aeii (p<0,05) ia?aaeuoaaa cia/aiiy oeueiai iieacieea o iaoe??io?a ? ? ?? a?oi (?en. 2). Aaniethoi? aaee/eie i?e?ino?a A ca 8 oeaeiaaee ia??iae i?eeiio ?AIO o ii??aiyii? c aeo?aeieie iieacieeaie (DA) aeey ? neeaee (12,51+5,17), O - (9,75+3,01) ? aeey A – (31,60+4,60) eAeae. ?en.2 Aaniethoi? aaee/eie caaaeueiiai ianyao aeeiiaii? ?iaioe ca ainueieoeaeiaaee ia??iae e?eoaaiiy (DA) ??cieie ?AIO. I?ei?oea. * - a?aei?ii?noue iieacieea ? a??ia?aeiith o ii??aiyii? c aeaiia ?ioeie a?oiaie. *an iaaeaethaaiiy a??ia?aeii ca?eueooaaany o an?o a?oiao. O?eaae?noue aeeiiaiiy iaaaioaaeaiiy c?inoaea o a??ia?aeii a?eueo?e i??? o oai?eo, ui iaea?aeoaaee A (aaniethoia aaee/eia i?e?inoo caaaeueii? o?eaaeino? AAI-oanoo ca 8-oeaeiaaee ia??iae o ii??aiyii? c aeo?aeieie iieacieeaie (Dt) noaiiaeea 7,34 +0,91 oa. ii??aiyiii c iaoe??ioaie ? ? ?? a?oi (aeey yeeo Dt neeaee 3,23+1,08 ? 3,77+1,10 oa., a?aeiia?aeii) (?<0,05). A??ia?aeia cieaeaiiy ye *NN?ae a?ae 116,23+4,48 oae/oa, oae ? AOn ?ae a?ae 133,67+2,98 ii ?o. no. i?e ii/aoeiaiio ianoaaeaii? aei 100,29+3,15 oae/oa ? 125,33+2,90 ii ?o. no. i?ney 2 oeaei?a (p<0,05) ? aei 104,49+3,12 oae/oa ? 127,59+3,97 ii ?o. no. i?ney 8 oeaei?a e?eoaaiiy A (p<0,05) iaoiiaeee a??ia?aeia cieaeaiiy IAe?ae a?ae 153,09+5,83 ia?aae ii/aoeii i?eeiio i?aia?aoo aei 125,20+4,41 ia ae?oaiio aoai? (p<0,05) ? aei 134,71+4,86 oi. iae. ia o?aoueiio aoai? aeine?aeaeaiiy (p<0,05). A a?oi? iaoe??io?a, ui iaea?aeoaaee ?, a??ia?aeia cieaeaiiy IAe?ae a?ae 179,56+9,30 aei 150,54+9,38 (p<0,05) ? aei 148,42+10,05 oi. iae. (p<0,05), a?aeiia?aeii ia ia?oiio, ae?oaiio i o?aoueiio aoaiao, cae?enithaaeiny ca ?aooiie cieaeaiiy *NN?ae a?ae 129,92+5,10 i?e ii/aoeiaiio aeine?aeaeaii? aei 114,69+5,78 i?ney 2 oeaei?a (p<0,05) ? aei 112,69+5,47 oae/oa i?ney 8 oeaei?a oa?ai?? (p<0,05). I?ae aieeaii O niinoa??aaeinue a??ia?aeia cieaeaiiy *NN?ae a?ae 133,18+5,71 aei 115,18+4,34 ia ae?oaiio (p<0,05) ? aei 116,81+4,84 oae/oa ia o?aoueiio aoaiao (p<0,05), iaeiae ci?ie IAe?ae ia aeinyaaee ??aiy a??ia?aeiino?. Aaee/eie IAeii??a. o an?o a?oiao oai?eo aeinoia??ii ia ci?ithaaeeny a oiae? aeine?aeaeaiiy.. Aeinoia??ia cieaeaiiy AA? a e?ioe? 8-oeaeiaaiai e?eoaaiiy niinoa??aaeiny i?ae aieeaii aeaio ?AIO: A a?ae 0,054+0,021 i?e ii/aoeiaiio aeine?aeaeaii? aei 0,012+0,002 oi. iae. (p<0,05) i?ney 8 oeaei?a oa?ai?? ? ? a?ae 0,096+0,012 ia?aae i?ecia/aiiyi e?eoaaiiy aei 0,055+0,012 oi. iae. (p<0,05) ia o?aoueiio aoai? aeine?aeaeaiiy. I?ney 8-ie oeaei?a e?eoaaiiy i?ae aieeaii O niinoa??aaeanue oaiaeaioe?y aei a??ia?aeiiai cieaeaiiy AA?. Ne?ae cacia/eoe i?ia?anoth/ee oa?aeoa? cieaeaiiy AA? ii i??? o?eaaeino? i?eeiio an?o o?ueio ?AIO. Aaaeeeaei iaoai?ciii caaacia/aiiy iiceoeaiiai aoaeoo ?AIO ia aaiiaeeiaieeo ? nenoie?/io ooieoe?th na?oey i?e e?eoaaii? inoaii?ie iiaea aooe iiaeeea?noue ciaioaiiy a i?aai?ci? ??aiy ii?aae?aiae?io. Ai?no ii?aae?aiae?io a aeiaia?e na/? o iaea?eueo?e i??? ciaiooaaany i?ae aieeaii A (ia 16,0%) ? O (ia 13,9%) (?en.3). Cacia/ai? ci?ie ai?noo ii?aae?aiae?io a aeiaia?e na/? aeinyaaee nooiaiy aeinoia??iino? o?eueee i?ae aieeaii A: niinoa??aaeiny ciaioaiiy aeuacaaaeaiiai iieacieea a?ae 177,05+10,12 ia?aae i?ecia/aiiyi i?aia?aoo aei 148,78+9,20 iiieue/aeiao i?ney 8 oeaei?a eiai i?eeiio (p<0,05). picscalex100010009000003880e00000c00130100000000050000000902000000000500 00000102ffffff000400000004010d000400000002010200050000000c02bb008f010300 00001e00040000002701ffff030000001e00040000002701ffff050000000b0200000000 030000001e00050000000102ffffff000500000009020000000010000000fb02f5ff0000 00000000bc02000000cc00000022417269616c00cc00040000002d01000010000000fb02 f5ff000000000000bc02000000020000001253796d626f6c0002040000002d0101001000 0000fb02f5ff000000000000bc020000000200000012526f6d616e000200040000002d01 0200040000002d010100040000002d010000040000002d010100040000002d0100000400 00002d01010004000000f001020010000000fb02f5ff000000000000bc02000000020000 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1e00040000002d010200040000002d010700040000002d01080005000000010200000000 050000000902ffffff00070000001604bb008f010000000009000000fa02000003000000 000000002200040000002d010a0004000000f001080005000000140219003f0005000000 0102ffffff000400000004010d000400000002010100050000001302a2003f0004000000 2d010000050000001402a2003c00050000001302a2003f000500000014028b003c000500 000013028b003f0005000000140274003c0005000000130274003f000500000014025e00 3c000500000013025e003f0005000000140247003c0005000000130247003f0005000000 140230003c0005000000130230003f0005000000140219003c0005000000130219003f00 05000000140219003f00050000001302190027010500000014021c003f00050000001302 19003f000500000014021c007900050000001302190079000500000014021c00b3000500 000013021900b3000500000014021c00ed000500000013021900ed000500000014021c00 270105000000130219002701040000002d010500040000002d010400040000002d010300 040000002701ffff030000001e00040000002d010000040000002d010700040000002d01 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00002d010500040000002d010400040000002d010300040000002701ffff030000001e00 040000002d010000040000002d010a00040000002d010800050000000102ffffff000500 00000902000000000700000016047a00860141003201040000002d010500040000002d01 0400040000002d010300040000002701ffff030000001e00040000002d01000004000000 2d010a00040000002d010800050000000102ffffff000500000009020000000007000000 16047a0086014100320109000000fa02000001000000000000002200040000002d010b00 04000000f0010800040000002d01070004000000f0010a00050000000902ffffff000500 00000102000000000400000004010d000400000002010200070000001b044f003d014800 360105000000090200000000050000000102ffffff000400000002010100040000002e01 18000b000000320a4f00400108000000d0e0ecb3eff0e8eb040000002e01000004000000 2d010500040000002d010400040000002d010300040000002701ffff030000001e000400 00002d010000040000002d010700040000002d010b00050000000102ffffff0005000000 0902000000000700000016047a00860141003201040000002d010500040000002d010400 040000002d010300040000002701ffff030000001e00040000002d010000040000002d01 0700040000002d010b00050000000102ffffff0005000000090200000000070000001604 7a0086014100320109000000fa02000001000000000000002200040000002d0108000400 0000f0010b000800000026060f000600ffffffff0000040000002d010600040000002d01 09000400000007010400050000000102ffffff0005000000090200000000350000004201 05000000280000000800000008000000010001000000000020000000c40e0000c40e0000 020000000200000000000000ffffff00c3f0f0f0c3f0f0f0c3f0f0f0c3f0f0f03c0f0f0f 3c0f0f0f3c0f0f0f3c0f0f0f04000400040008000800080008000800040000002d010a00 040000002d010a00090000001d062100f000060006005b003601040000002d010a000500 000009020100000005000000010201000000040000002d01090004000000f0010a000400 00002d010800040000002d01070004000000070101000800000026060f000600ffffffff 010007000000fc020100000000008020040000002d010a00050000000102000000000400 000004010d000400000002010200070000001b0462003d015b003601040000002d010700 04000000f0010a00050000000102ffffff000400000002010100040000002e0118000c00 0000320a620040010a000000d4eee7b3edeeeff0e8eb040000002e010000040000002d01 0500040000002d010400040000002d010300040000002701ffff030000001e0004000000 2d010000040000002d010700040000002d010800050000000102ffffff00050000000902 000000000700000016047a00860141003201040000002d010500040000002d0104000400 00002d010300040000002701ffff030000001e00040000002d010000040000002d010700 040000002d010800050000000102ffffff00050000000902000000000700000016047a00 86014100320109000000fa02000001000000000000002200040000002d010a0004000000 f00108000800000026060f000600ffffffff0000040000002d010600040000002d010900 0400000007010400050000000102ffffff00050000000902000000003500000042010500 0000280000000800000008000000010001000000000020000000c40e0000c40e00000200 00000200000000000000ffffff00ffffffffffffffffffffffffdff7f7f7ffffffffffff fffffffffffffd7f7f7f00000000000000000000000000000000040000002d0108000400 00002d010800090000001d062100f000060006006e003601040000002d01080005000000 09020100000005000000010201000000040000002d01090004000000f001080004000000 2d010a00040000002d01070004000000070101000800000026060f000600ffffffff0100 07000000fc020100000000008020040000002d0108000500000001020000000004000000 04010d000400000002010200070000001b0475003d016e003601040000002d0107000400 0000f0010800050000000102ffffff000400000002010100040000002e0118000c000000 320a7500400109000000c5ede0ebe0eff0e8eb00040000002e010000040000002d010500 040000002d010400040000002d010300040000002701ffff030000001e00040000002d01 0000040000002d010700040000002d010a00050000000102ffffff000500000009020000 00000700000016047a00860141003201040000002d010500040000002d01040004000000 2d010300040000002701ffff030000001e00040000002d010000040000002d0107000400 00002d010a00050000000102ffffff0005000000090200000000070000001604bb008f01 00000000040000002d010700040000002d01050004000000f0010a00040000002701ffff 050000000c02bb008f01030000001e00050000000102ffffff0005000000090200000000 040000002701ffff050000000b0200000000030000001e00050000000102ffffff000500 000009020000000004000000f0010200040000002701ffff030000000000 ?en.3 Aaniethoi? aaee/eie i?e?ino?a ai?noo ii?aae?aiae?io a aeiaia?e na/? ca ainueieoeaeiaaee ia??iae e?eoaaiiy (DHA) ??cieie ?AIO. Aeine?aeaeaiiy no?oeoo?iiai noaio iaia?ai a?eo?ioeeo?a iieacaei, ui oa?ai?y A, ia i?ioeaaao O ? ?, i?ecaiaeeea aei aeinoia??iiai ciaioaiiy aeoeaiino? oa?iaioo aioeieneaeaioiiai caoenoo eaoaeace a?ae 14,39+0,42 ia?aae e?eoaaiiyi aei 11,31+0,49 ieao/ie/iei i?ney 8 oeaei?a i?eeiio i?aia?aoo (p<0,05). Ia a?aei?io a?ae O ? A, i?ae aieeaii ? niinoa??aaeanue oaiaeaioe?y aei cieaeaiiy ni?aa?aeiioaiiy oieanoa?ei/oinoie?i?aee (On/Oe). ? ciaiooaaa ai?no ii/aoeiai i?aeaeuaieo ae??iiaeo eii’thaao (AeE) (p<0,05) o iaia?aiao a?eo?ioeeo?a. Ioe?ithth/e nooi?iue ae?aciino? i?eai?/aiiy AIO i?ae aieeaii aeine?aeaeaieo i?aia?ao?a, ne?ae cacia/eoe, ui o iaea?eueoee i??? oeae aoaeo niinoa??aaany a e?ioe? 8-oeaeiaaiai i?eeiio O ? A. O /eiea aeinoia??ia cieaeaiiy aeoeaiino? AIO a?ae 6,98+0,58 ia?aae ii/aoeii e?eoaaiiy aei 5,24+0,62 iiieue/ie iei-1 (p<0,05) i?ney eiai cae?i/aiiy. I?ae aieeaii o?eaaeiai e?eoaaiiy A a?aecia/aeiny ciaioaiiy aeoeaiino? oa?iaioo aei 6,40+0,52 ii??aiyiii c 8,05+0,77 iiieue/ie iei-1 aei ii/aoeo e?eoaaiiy (p<0,05). Cieaeaiiy aeoeaiino? AIO i?ae aieeaii ? ia aeinyaaei nooiaiy aeinoia??iino?. Aeine?aeaeaiiy aeayeeo a?io?i?/ieo eiinoaio ieacie e?ia? (E+, Na+, e?aaoei?i) aeyaeei, ui o?eaaea e?eoaaiiy ?AIO o an?o o?ueio a?oiao oai?eo ia aeeeeea? aeinoia??ieo ci?i iieaciee?a aeaeo?ie?oiiai iai?io, ooieoe?iiaeueiiai noaio ie?ie. Io?eiai? ?acoeueoaoe iaa?oioiaothoue iaiao?aei?noue iiaeaeueoeo aeine?aeaeaiue ii ii??aiyeueiiio aea/aiith ?AIO. AENIIAEE 1. Aeeth/aiiy eiaeiiai c aea/aieo ?AIO (?, O, A) aei aacenii? oa?ai?? na?oeaai? iaaeinoaoiino? (oo?inai?ae, ae?aienei) noi?iaiaeaeo?oueny aeinoia??iei iie?auaiiyi ee?i?ei-ooieoe?iiaeueiiai noaio oai?eo. 2. An? cacia/ai? ?AIO iie?ioothoue iieacieee aioo??oiueina?oeaai? aaiiaeeiai?ee, ui iieyaa? a ciaioaii? ?ici??o EI, ENI EO, ca?eueoaii? OA EO. A?eueo a?ae/ooia iie?auaiiy aoiea?ae?ia?ao?/ieo ia?aiao??a nenoie?/ii? ooieoe?? EO niinoa??aa?oueny i?ae aieeaii O: aeinoia??ii a?eueo ae?acia ciaioaiiy ENI EO o ii??aiyii? c oai?eie, ui io?eioaaee ? ? A, aeinoia??ii a?eueo ae?acia ciaioaiiy EAeI EO ii??aiyiii c iaoe??ioaie, ui io?eioaaee ?, ? aeinoia??ii a?eueo ae?acia ciaioaiiy EI ii??aiyiii c iaoe??ioaie, ui e?eoaaeenue A. 3. Ia oe? i?eeiio an?o cacia/aieo ?AIO niinoa??aa?oueny aeinoia??ia iie?ioaiiy iieaciee?a i?aoeacaeaoiino? oai?eo (ianyao aeeiiaii? ?iaioe oa /ano iaaeaethaaiiy), ui a iaea?eueo?e i??? ae?acia a a?oi? iaoe??io?a, ye? io?eioaaee A. Canoinoaaiiy ? ? A noi?iaiaeaeo?oueny aeiiii?caoe??th aaiiaeeiai?/iiai caaacia/aiiy iaaaioaaeaiiy, i?i ui na?ae/eoue i?ia?anoth/ee oa?aeoa? cieaeaiiy iieacieea AA? ai?iaeiaae o?eaaeiai e?eoaaiiy, cieaeaiiy *NN, AOn, “iiaea?eiiai aeiaooeo” ia ?aeaioe/iiio ??ai? AAI-oanoo. 4. Ia a?aei?io a?ae O ? A, i?eeii ? cieaeo? ni?aa?aeiioaiiy oieanoa?ei/oinoie?i?aee oa ai?no ae??iiaeo eii’thaao o iaia?aiao a?eo?ioeeo?a, ui iiaea na?ae/eoe i?i cieaeaiiy aei?noeino? iaia?ai ? ciaioaiiy ?ioaineaiino? i?ioean?a IIE. 5. Ia i?ioeaaao O ? ?, A aeinoia??ii i?eai?/o? aeoeai?noue aiceia aioeieneaeaioiiai caoenoo - eaoaeace, aea, ia a?aei?io a?ae ieo, coiiaeth? aeinoia??ia cieaeaiiy eiioeaio?aoe?? ii?aae?aiae?io a aeiaia?e na/?. 6. E?eoaaiiy an?ia o?ueiia aea/aieie ?ia?a?oi?aie AIO noi?iaiaeaeo?oueny ciaioaiiyi aeoeaiino? AIO o ieaci? e?ia?, yea ? aeinoia??ii ae?aaeaiei a a?oiao iaoe??io?a, ui io?eioaaee A ? O. I?AEOE*I? ?AEIIAIAeAOe?? 1. sse i?aia?ao aeai?o i?e e?eoaaii? oai?eo ?c ONI II-III OE aa?oi ?icaeyaeaoe A, yeee /eieoue, ca aeaieie i?iaaaeaiiai aeine?aeaeaiiy, a?eueo ae?aciee, o ii??aiyii? ?c ? ? O, ni?eyoeeaee aieea ia o?ce/io i?aoeacaeaoi?noue oa aaiiaeeiai?/ia caaacia/aiiy iaaaioaaeaiiy. 2. I?e ae?aaeai?e nenoie?/i?e aeenooieoe?? ? aeeeyoaoe?? e?aiai oeoii/ea iaea?eueo ae?aaeaiiai ei?aaoth/iai aieeao ia eiai ?aiiaeaethaaiiy ne?ae i/?eoaaoe a?ae O. 3. I?e eaai?aoi?ii aeiaaaeai?e aeoeaaoe?? i?ioean?a e?iiia?ieneaeaoe?? o oai?eo ?c ONI oe?eeii aei?aaaeaiei ? aeei?enoaiiy ? ye i?aia?aoo, ui /eieoue aioeieneaeaioio ae?th ? iie?auo? no?oeoo?ii-ooieoe?iiaeueiee noai ee?oeiieo iaia?ai. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. Ai?iieia E.A., Aoiueeiaa A.A. ?ai?i?ee – ?ia?a?oi? aia?ioaicei-ia?aoai?thth/iai oa?iaioo ??? iieie?iiy // E?ee.- 1997.-?1.- N. 12-16. 2. Ai?iieia E.A., Aoiueeiaa A.A., Ioeoa?yi E.N., Eeueyo I.A. Eeeieei-oa?iaeiaeeiaie/aneea yooaeou ?aiei?eea (Tritace) o aieueiuo n o?iie/aneie na?aea/iie iaaeinoaoi/iinoueth //Oe?. ea?ae?ie. aeo?iae.-1997.-?3.-N. 11-13. 3. Ai?iieia E.A., Aoiueeiaa A.A., Io?oa?yi E.N., Eeeyo I.A. Ee?i?ei-oa?iaeiaeeiai?/i? aoaeoe ?ai?i?eeo oa aiaeai?eeo o oai?eo ?c o?ii?/iith na?oeaaith iaaeinoaoi?noth //Oe?. ea?ae?ie. aeo?iae.-1998.-?2.-N. 37-39. 4. Ai?iieia E.A., Aoiueeiaa A.A., Io?oa?yi E.N., Eeeyo I.A. Aiaeai??e oa ?ai?i??e i?e o?ii?/i?e na?oeaa?e iaaeinoaoiino?: ii??aiyeueia aeine?aeaeaiiy // Iaoa??aee OIV c’?caeo oa?aiaao?a Oe?a?ie.-Ee?a.-1998.-N. 39. 5. Ai?iieia E.A., Aoiueeiaa A.A., Eeueyo I.A. Eeeieei-oa?iaeiaeeiaie/aneea yooaeou ?aiei?eea o aieueiuo n o?iie/aneie na?aea/iie iaaeinoaoi/iinoueth // Iaoa?eaeu I eiia?anna annioeeaoeee ea?aeeieiaia no?ai NIA.- Iineaa.-1997.-N. 84. 6. Ai?iieia E.A., Aoiueeiaa A.A., Eeueyo I.A., Ioeoa?yi E.N. Eeeieei-aaiiaeeiaie/aneea yooaeou ?aiei?eea o aieueiuo n o?iie/aneie na?aea/iie iaaeinoaoi/iinoueth // Oacenu iaaeaeoia?iaeiie eiioa?aioeee “O?iie/aneay na?aea/iay iaaeinoaoi/iinoue”.-I?aiao?a.-1998.-N.36. AIIOAOe?ss Aoiueeiaa A.A. Ii??aiyiiy ee?i?ei-oa?iaeiaeeiai?/ieo aoaeo?a ?ai?i?eea, oic?iii?eea oa aiaeai?eea o oai?eo ?c o?ii?/iith na?oeaaith iaaeinoaoi?noth. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 - ea?ae?ieia?y. - ?inoeooo ea?ae?ieia?? ?i. aeaaeai?ea I.Ae.No?aaeanea AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?y i?enay/aia i?iaeai? e?eoaaiiy oai?eo ?c o?ii?/iith na?oeaaith iaaeinoaoi?noth (ONI) ?ia?a?oi?aie AIO. A i?ioean? aeeiiaiiy ?iaioe a ii??aiyeueiiio ieai? aeyaeai? oa iienai? iniaeeaino? aieeao ??cieo ?ia?a?oi??a AIO (?ai?i?ee, oic?iii?ee oa aiaeai?ee) ia ia?aiao?e aaiiaeeiai?ee, oiea?aioi?noue aei o?ce/iiai iaaaioaaeaiiy, oa?aeoa? ?? caaacia/aiiy, a oaeiae ia iieacieee aeoeaiino? neiiaoi-aae?aiaeiai? nenoaie ? noaie ieneaeaioii? oa aioeieneaeaioii? nenoai oai?eo ?c ONI. Eeth/ia? neiaa: o?ii?/ia na?oeaaa iaaeinoaoi?noue, e?eoaaiiy, ?ia?a?oi?e AIO, ?ai?i?ee, oic?iii?ee, aiaeai?ee. SUMMARY Gun’kova G. Comparison of clinical and pharmacodynamical effects of ramipril, fosinopril and enalapril in patients with chronic heart failure.- Manuscript. Thesis for a candidate degree in the speciality 14.01.11 – cardiology. – Institute of Cardiology of Medical Sciences Academy, Kyiv, 1999. The dissertation is devoted to the problem of chronic heart failure (CHF) patients treatment with ACE inhibitors. Peculiarities were revealed and described of various ACE inhibitors (ramipril, fosinopril and enalapril) effects on hemodynamical parameters, tolerance to physical loading, character of its maintenance, and also on parameters of sympathic system activity and condition of oxydant and antioxydant systems in the patients with CHF during work performance. Key words: chronic heart failure, treatment, ACE inhibitors, ramipril, fosinopril, enalapril. AIIIOAOeEss Aoiueeiaa A.A. N?aaiaiea eeeieei-oa?iaeiaeeiaie/aneeo yooaeoia ?aiei?eea, oiceiii?eea e yiaeai?eea o aieueiuo n o?iie/aneie na?aea/iie iaaeinoaoi/iinoueth. ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 – ea?aeeieiaey. – Einoeooo ea?aeeieiaee ei. aeaae. I.Ae.No?aaeanei AII Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia i?iaeaia n?aaieoaeueiie ioeaiee eeeieei-oa?iaeiaeeiaie/aneeo yooaeoia eiaeaeoi?ia AIO –?aiei?eea, oiceiii?eea e yiaeai?eea o aieueiuo n o?iie/aneie na?aea/iie iaaeinoaoi/iinoueth (ONI). Onoaiiaeaii, /oi ana eco/aiiua eiaeaeoi?u AIO e eiioeo ainueie iaaeaeue ea/aiey aeinoiaa?ii oeo/oatho ooieoeeiiaeueiia ninoiyiea aieueiuo e ia?aiineiinoue eie oece/aneie iaa?ocee. Iaeaieaa au?aaeaiiiio iiauoaieth oece/aneie ?aaioiniiniaiinoe o aieueiuo n ONI e oeo/oaieth aaiiaeeiaie/aneiai iaania/aiey oece/aneie iaa?ocee niinianoaoao oa?aiey yiaeai?eeii ii n?aaiaieth n oiceiii?eeii e ?aiei?eeii. Ioia/aii, /oi ana eco/aiiua iaie eiaeaeoi?u AIO ieacuaatho iaeiiiai?aaeaiiia iioeiece?othuaa aicaeaenoaea ia iieacaoaee aioo?ena?aea/iie aaiiaeeiaieee, ninoiyuea a oiaiueoaiee ?acia?a eaaiai i?aaena?aeey, eiia/ii-nenoiee/aneiai iauaia eaaiai aeaeoaei/ea (EAE) e oaaee/aiee aai o?aeoeee aua?ina. Iaeaieaa au?aaeaiiia ei??aae?othuaa aeeyiea ia ?aiiaeaee?iaaiea EAE i?e nenoiee/aneie aeenooieoeee ieiea?aea ieacuaaao oiceiii?ee a n?aaiaiee n yiaeai?eeii e ?aiei?eeii. A ioee/ea io oiceiii?eea e yiaeai?eea, ?aiei?ee ieacuaaao aioeieneaeaioiia e iioeiece?othuaa aeaenoaea ia no?oeoo?ii-ooieoeeiiaeueiia ninoiyiea iaia?ai. Aeeeoaeueiue i?eai yiaeai?eea, a ioee/ea io oiceiii?eea e ?aiei?eea, nii?iaiaeaeaaony nieaeaieai eiioeaio?aoeee ii?aae?aiaeeia a nooi/iii eiee/anoaa ii/e o aieueiuo n ONI. Onoaiiaeaii aeinoiaa?iia nieaeaiea aeoeaiinoe AIO a nuai?ioea e?iae iiae aeeyieai yiaeai?eea e oiceiii?eea. Eeth/aaua neiaa: o?iie/aneay na?aea/iay iaaeinoaoaoi/iinoue, ea/aiea, eiaeaeoi?u AIO, ?aiei?ee, oiceiii?ee, yiaeai?ee. IA?AE?E OIIAIEO IICIA*AIUe A – ?iaioa AOn – a?oa??aeueiee oene nenoie?/iee AAI - aaeia?aiiao??y A –aiaeai?ee AoiEA - aoiea?ae?ia?ao?y ?AIO – ?ia?a?oi?e aia?ioaicei-ia?aoai?thth/iai oa?iaioo ?ae – ?aeaioe/iee ??aaiue iaaaioaaeaiiy aaeia?aiiao?e/iiai oanoo EAeI – e?ioeaai-ae?anoie?/iee ia’?i ENI – e?ioeaai-nenoie?/iee ia’?i EO –e?aee oeoii/ie IAe – iiaea?eiee aeiaooie ii??a – ii?iaiaee ??aaiue iaaaioaaeaiiy aaeia?aiiao?e/iiai oanoo ? –?ai?i?ee OOI – oiea?aioi?noue aei o?ce/iiai iaaaioaaeaiiy O - oic?iii?ee OE – ooieoe?iiaeueiee eean *NN – /anoioa na?oeaaeo nei?i/aiue

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