OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Cae/aiei Ieueaa ?aaai?aia

OAeE
616.12008.46+616.124.2:/615.225.2:615.355

II??AIssEUeIA IAOAAIE?*IA OA AAIIAeEIAI?*IA AOAEOEAI?NOUe
?IA?A?OI??A AIA?IOAICEIIA?AOAI?THTH*IAI OA?IAIOO I?E AeENOOIEOe?? E?AIAI
OEOII*EA OA II?OOAIIssO NA?OeAAIAI ?EOIO

14.01.11 Ea?ae?ieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a 1998

Aeena?oaoe??th ? ?oeiien

?iaioo aeeiiaii a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

IIC Oe?a?ie

Iaoeiaee ea??aiee: caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,

aeieoi? iaaee/ieo iaoe, i?ioani?

Eaoiaoc ?aai E?iae?aoiae/,

Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao,

caa?aeoaa/ eaoaae?e aioo??oi?o
oai?ia, EOE oa NI.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Eiaaeueiaa Ieueaa Ieeiea?aia,

Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, caa?-

aeoaa/ eaoaae?e i?iiaaeaaoeee
aioo??oi?o oai-

?ia ? 1;

aeieoi? iaaee/ieo iaoe

I?eieaiei ?aaai sseiae/,

?inoeooo oa?ai?? AII Oe?a?ie,
canooiiee aee?aeoi?a

c iaoeiai? ?iaioe .

I?ia?aeia onoaiiaa: Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo
ea?ae?ieia??

?i. aeaaeai?ea I.Ae. No?aaeanea,
i. Ee?a, a?aeae?eaiiy

aoa?ineea?ico oa o?ii?/ii? ?oai?/ii?
oai?iae na?oey.

Caoeno a?aeaoaeaoueny 11 ethoiai 1999 ?. i 13.30 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae. 64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca aae?anith: 310022, i. Oa?e?a,
i?iniaeo Eai?ia,4.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( i. Oa?e?a, i?ini. Eai?ia,4).

Aaoi?aoa?ao ?ic?neaiee 9 n?/iy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe, aeioeaio .
Ia/a?aiei E. ?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE.

Aeooaeueiinoue oaie. A inoaiii ?iee aeinyaiooi cia/ii oniioe a
aeiaaiinoeoei oa eieoaaiii ii?ooaiue ?eoio oa i?iaiaeiinoi na?oey.
Aeineiaeaeaiiy, ui i?iaiaeeeenue, aeaee ciiao anoaiiaeoe, ui ii?ooaiiy
?eoio o aieueoinoi aeiaaeeia aeieeathoue i?e i?aaii/ieo o?aaeaiiyo
na?oeaai-noaeeiii? nenoaie (Eooaeianueeee I.N.,1992-1993, Iaea E.O.,
Eaoiaoc ?. E., 1993, Iaco? I. A., 1995). Aeineoue /anoi ii?ooaiiy ?eoio
na?oey iathoue iinoea ia oiii aeenooieoei? eiaiai oeoii/ea o oai?eo ia
ioaii/io oai?iao na?oey (?ON), ui aieeaa? ia ia?aaia caoai?thaaiiy oa
eiai i?iaiic. (Aiiniaa I.I., Aia?ia A. I., AEa?i-iia I.E. 1995,
Podrid P.J., Fogel K. L., Fuchs T. S.,1992 ). Iae/anoioa i?e yaiie aai
eaoaioiie aeenooieoei? eiaiai oeoii/ea, ca aeaieie oieoa?ianueeiai
iiiioi?oaaiiy AEA, cono?i/a?oueny oeoieiaa aeno?a-nenoieiy (80%
aeiaaeeia) i ianoieea oeoii/eiaa oaoiea?aeiy (aieueo 40%
aeiaaeeia). (Aia?ia A. I., AEa??iia I. E. 1995, Eooaeianueeee I. N.,
1993 ).

Iiyaa oeoii/eiaeo ii?ooaiue ?eoio oa ?o a?aaeaoeiy a cia/iie ii?i
caeaaeaoue aiae ae?aaeaiinoi canoieieo yaeu i ooieoeiiiaeueiiai noaio
oai?eo ( Aiiniaa I.I., 1994, Parmley W. W., 1987). A ca’yceo c oeei
aaaeeeaa cia/aiiy ia? aeei?enoaiiy i?aia?aoia, ui ciaioothoue nooi?iue
aeenooieoei? na?oeaaiai i’yca. (Iia?eiaa E. N., A?aa?aeca A. A., 1990,
Neoiie N. I., Iaeeoei E. I., 1994).

Na?aae iaaeeeaiaioicieo caniaia, ui aeei?enoiaothoueny i?e
aeenooieoei? iiiea?aea, aaaeeeaa iinoea caeiathoue iiaiaioi?e
aiaiioaiceiia?aoai?thth/iai oa?iaioo (AIO) ( Ai?iieia E.A., ?yaaiei
Ae.A., 1994, Bielem E.C., Fagard R. H., 1992). Caiiaiaath/e aieeao
aiaiioaiceio ?? ia na?oea, iiaiaioi?e AIO ni?eythoue ciaioaiith
aiia?o?ioi? iiiea?aea, iie?auothoue iaoaaieici a na?oeaaiio i’yci,
ciaioothoue ei?iia?iniaci ( Rogers W., Johnstone D., 1994 ). E?ii oiai,
caaaeyee aaciaeeeaooth/ie aei? cieaeaiith ia?aae- oa iinoiaaaioaaeaiiy,
iiaiaioi?e AIO caiiaiaathoue i?ia?anoaaiith aeeeaoaoe?? eiaiai oeoii/ea,
ciaioothoue nooi?iue iaaeinoaoiinoi e?iaiiaiao ( ?yaaiei Ae. A., 1996,
Naeuaiei ?. I., 1995 ).

Aieea ia na?oea iiaiaioi?ia AIO caeienith?oueny ca aeiiiiiaith
iae?iaoii?aeueieo iaoaiiciia, oaeeo ye iiaeaeuaiiy aeoeaiinoi ?aiiio,
cieaeaiiy ?iaiy aeueaeinoa?iio, iiaeaeuaiiy ?iaiy a?aaeeeiiiio,
iineeaiiy neioaco i?inoaaeaiaeeiia. (Ieuea?inueea E. ?., Ii?iciaa O. ?.,
1993, N??aiei TH. I., 1994, Robertson J. S., 1993 ). Aeieeiaiiy
oeoii/eiaeo a?eoiie o oai?eo c o?iii/iith na?oeaaith iaaeinoaoiinoth
(ONI), ui cia/ii iia??oothoue i?iaiic aeey aeeooy, cae/aeii
caeienith?oueny ia oei iae?iaoii?aeueieo ii?ooaiue, ye? onoaathoueny
iiaiaioi?aie AIO ( Aia?ia A. I., AEa??iia I. E., 1995). Ana oea
aeicaiey? i?eioneaoe iiaeeeainoue aeei?enoaiiy iiaiaioi?ia AIO i?e
oeoii/eiaeo a?eoiiyo o oai?eo c aeenooieoei?th iiiea?aea ?iciiai aaiaca.
( Aaeaieia TH. I., Aaa?a O. O., Ia?onaa A. TH., 1996 ).

Aea aei oeueiai /ano iaaeinoaoiuei aea/aia ieoaiiy i?i aieea
iiaiaioi?ia AIO ia iniiai? eaiee iaoiaaiaco a?eoiie o oai?eo c
aeenooieoei?th eiaiai oeoii/ea oa aac ia?, i?aeoe/ii aiaenooii aeai? i?i
ea?aeiiaaiiaeeiaii/ii i iaoaaiei/ii aoaeoe iiaiaioi?ia AIO i?e
ii?ooaiiyo na?oeaaiai ?eoio, ia aea/aii iiaeeeainoi niieo/aiiai
aeei?enoaiiy iiaiaioi?ia AIO, aioaaiiinoia ?aoeaioi?ia aiaiioaiceio II
i?e a?eoiiyo, iaaeinoaoiuei ?ic?iaeaii iaoiaee ia’?eoeaii? ioeiiee
aoaeoeaiinoi iiaiaioi?ia AIO i?e ii?ooaiiyo ?eoio ca aeiiiiiaith
iaiiaaceaieo iaoiaeia. Oaeei /eiii, aeine?aeaeaiiy a oe?e iaeano? ?
aeooaeueieie ? iiaeooue ni?eyoe iioei?caoe?? e?eoaaiiy oai?eo c
aeenooieoe??th e?aiai oeoii/ea oa a?eoi?yie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa ? /anoeiith caaaeueii? eaoaae?aeueii? iaoeiai? oaie “
Iaoieiaiy na?oeaai-noaeeiii? nenoaie”, “Eeii?ei-aiio?i?/ii aniaeoe
aeiaaiinoeee oa eieoaaiiy ioaii/ii? oai?iae na?oey i?e niiaoe/ieo oa
aiaeie?eiieo caoai?thaaiiyo”, ? aea?ae. ?a?no?aoe?? 01950023462.

Iaoa ? caaea/? aeine?aeaeaiiy

Iaoith ?iaioe aoei iie?auaiiy e?eoaaiiy ii?ooaiue na?oeaaiai
?eoio o oai?eo c aeenooieoe??th e?aiai oeoii/ea ca aeiiiiiaith
aecia/aiiy ii?iaiyeueii? iaoaaiei/ii? oa aaiiaeeiaii/ii? aoaeoeaiinoi
iiaiaioi?ia AIO.

Aeey caeieniaiiy anoaiiaeaii? iaoe aeineiaeaeaiiy ieaioaaeiny ae?ioeoe
oae? caaea/i:

1. Aea/eoe eeii?/io aoaeoeaiinoue iiaiaioi?ia AIO i?e oeoii/eiaeo

a?eoiiyo o oai?eo c aeenooieoei?th eiaiai oeoii/ea.

2. Ioeiieoe iaoaaiei/io aoaeoeaiinoue iiaiaioi?ia AIO; ?o aieea ia
?aiii-aiaiioaicei-aeueaeinoa?iiiao nenoaio, iaiii aeaeo?ie?oia.

3. Aecia/eoe ae?aaeai?noue aieeao iiaiaioi?ia AIO ia
ea?aeiiaaiiaeeiaiieo o oai?eo c aeenooieoei?th eiaiai oeoii/ea oa
a?eoiiyie.

4. Ioeiieoe ae?aaeai?noue iaoaaiei/ieo aoaeoia iiaiaioi?ia AIO i?e
ii?ooaiiyo na?oeaaiai ?eoia ca aeiiiiiaith eaai?aoi?ieo oa iaiiaaceaieo
iino?oiaioaeueieo iaoiaeia aeineiaeaeaiiy.

5. Aea/eoe eieoaaeueii iiaeeeainoi eiiaiiiaaii? oa?aii? ii?ooaiue ?eoio
na?oey ca aeiiiiiaith iiaiaioi?ia AIO, aioaaii?noia ?aoeaioi?ia
aiaiioaiceio II.

6. Ca iaea?aeaieie ?acoeueoaoaie ?ic?iaeoe i?ia?aio ?aoeiiiaeueii?
oa?aii? o oai?eo c aeenooieoei?th eiaiai oeoii/ea oa a?eoiiyie.

Iaoeiaa iiaecia

A ?iaioi aia?oa aeine?aeaeaia eeii?/ia oa iaoaaie?/ia
aoaeoeaiinoue iiaiaioi?ia AIO o oai?eo c aeenooieoei?th eiaiai oeoii/ea
oa a?eoiiyie. Aeyaeaii iniaeeainoi iae?iaoii?aeueieo ii?ooaiue i?e
aeenooieoei? eiaiai oeoii/ea i a?eoiiyo, aecia/aii iaeaieueo
?aoeiiiaeueii oeyoe ei?aeoei? ca aeiiiiiaith iiaiaioi?ia AIO.

Aia?oa aea/aia iiaeeeainoue aeei?enoaiiy eaai?aoi?ieo i
iaiiaaceaieo iino?oiaioaeueieo iaoiaeia aeey ioeiiee aoaeoeaiinoi
oa?aii? iiaiaioi?aie AIO o oai?eo c aeinooieoei?th eiaiai oeoii/ea i
a?eoiiyie. Iieacaii, ui iiae aieeaii iaaeeeaiaioicii? oa?aii?
iiaiaioi?aie AIO o oai?eo c aeenooieoei?th eiaiai oeoii/ea ia oei
ii?iae?caoe?? iae?iaoii?aeueiiai noaoono i iieiioaiiy
ea?aeiiaaiiaeeiaii/ieo iieacieeia cia/ii cieaeo?oueny /anoioa
oeoii/eiaeo a?eoiie.

I?aeoe/ia cia/aiiy ?iaioe

I?aeoe/ia cia/aiiy ?acoeueoao?a aeineiaeaeaiue, ui aoee
i?iaaaeaii, iieyaa? o oiio, ui iieacaia aeioeieueiinoue i?ecia/aiiy
iiaiaioi?ia AIO oai?ei c ii?ooaiiyie na?oeaaiai ?eoio ia oei
aeenooieoei? iiiea?aea eiaiai oeoii/ea; anoaiiaeaii, ui iiaiaioi?e AIO
ni?eythoue ?aa?ani? aiia?o?ioi? eiaiai oeoii/ea, oiaoi iathoue
ea?aeii-i?ioaeoi?io aeith; aeieacaii, ui o oai?eo ia ioaii/io oai?iao
na?oey iiaiaioi?e AIO ciaioothoue nooi?iue na?oeaai? iaaeinoaoiinoi, ui
ni?ey? ciaioaiith /anoioe a?eoiie, cieaeaiith nooiaith ioaii? iiiea?aea
ia AEA, i?aeaeuaiith oiea?aioiino? aei o?ce/iiai iaaaioaaeaiiy ;
iieacaia aaaeeeainoue aeei?enoaiiy iaiiaaceaieo iaoiaeia aeineiaeaeaiiy
aoiea?aeiia?aoi?, oieoa?ianueeiai iiiioi?oaaiiy, i?ia c iaaaioaaeaiiyi
aeey ioeiiee aoaeoeaiinoi eieoaaiiy iiaiaioi?aie AIO oai?eo c
aeenooieoei?th eiaiai oeoii/ea i a?eoiiyie.

?acoeueoaoe aeineiaeaeaiue aeei?enoiaothoueny a ?iaioi
Aei?iaeii? eeiii/ii? eiea?ii ? 2 ( ea?aeiieiai/iiio oa iioa?eoiiio
aiaeaeieaiiyo); Oa?e?anueei? iaeanii? ee?i?/ii? e?ea?i?;
oa??oi??aeueiiio iaaee/iiio ia’?aeiaii? I?aeaeii?eiaecaanueeiai ?-io i.
Oa?eiaa: 12-e eiea?ii, 25-e eeii?/iie eiea?ii oa ?ioeo e?eoaaeueieo
caeeaaeao i. Oa?eiaa. Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy o
ee?i?/io i?aeoeeo aeicaiey? i?aeae-ueoe aoaeoeai?noue e?eoaaiiy,
iie?ioeoe noai o aeinoaoiuei aaaeeiai eiio?iaaioo oai?eo, ciaioeoe
o?eaae?noue ia?aaoaaiiy a noaoe?iia??. Iaoa??aee aeena?oaoe??
aeei?enoiaothoueny a iaa/aeueii-iaaeaaia?/iiio i?ioean? ia eaoaae??
aioo??oi?o oai?ia, EOE oa NI Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a

Naiinoieii cae?enithaaea iiaeai? oa ianoaaeaiiy oaiaoe/ieo oai?eo
c aeei?enoaiiyi eeiiiei-iino?oiaioaeueieo oa eaai?aoi?ieo iaoiaeia,
?ic?iaeyea i?ia?aie aeeoa?aioeieiaaiiai eieoaaiiy iaoei?ioia. Ieaio-
aaea iaoo, caaea/i aeineiaeaeaiiy oa caeienithaaea eiio?ieue ca
aoaeoeaiinoth eieoaaiiy. I?iaiaeeea noaoenoe/io ia?iaeo io?eiaieo
?acoeueoaoia oa ?o aiaeic, ioi?ieyea aeena?oaoeieio ?iaioo.

Ai?iaaoe?y ?acoeueoao?a ?iaioe

Iaoa?iaee aeena?oaoeieii? ?iaioe aoee aeieeaaeaii i iaaiai?aii
ia iaoeiai-i?aeoe/ieo eiioa?aioeiyo iieiaeeo a/aieo iaaeeeia ( Oa?eia,
1996, 1997) ; caniaeaiii iaaee/iiai iaoeiaiai oiaa?enoaa (Oa?eia,1997);

iaoeiai-i?aeoe/iie eiioa?aioei? , i?enay/aiie i?iaeaiai caeicie/ii?
iaaeeoeeie ( Oa?eia, 1997 ); III-io Iiaeia?iaeiiio eiia?ani ii
aeaeo?inoeioeyoei? i eeii?/iie aeaeo?ioiciieiai? na?oey (
Ea?aeiinoii-98, Naieo-Iaoa?ao?a, 1998 ); OIV c’?cae? oa?aiaao?a Oe?a?ie
( Ee?a, 1998 ); II- e Oe?a?inuee?e iaoeia?e eiioa?aioe?? c
i?aeia?iaeiith o/anoth “Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??” (
A?iieoey, 1998).

Ioae?eaoe??

Ca oaiith aeena?oaoe?? iioae?eiaaii 8 ?ia?o a iaoeiaeo
aeaeaiiyo, c

ieo 4 noaoo?, 4 oace aeiiia?aeae.

No?oeoo?a oa ianya aeena?oaoe??

?iaioa aeeeaaeaia ia 130 noi??ieao iaoeiiieniiai oaenoo, i?noeoue
5 oaaeeoeue, 11 iaethie?a ? neeaaea?oueny ?c anooio, 2-o aeaa iaeyaeo
e?oa?aoo?e, 7-? aeaa aeanieo niinoa?aaeaiue, iaaiai?aiiy ?acoeueoao?a
aeine?aeaeaiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, ia?ae?eo
aeei?e-noaii? e?oa?aoo?e. Nienie aeei?enoaieo aeaea?ae i?noeoue 278
?ia?o, c ieo 93 aaoi??a e?a?i NIAe, 185 ?iicaiieo aaoi??a.

Ciino ?iaioe

Iaoa?iaee i iaoiaee

Ianoaaeaii 128 oai?eo ia ioaii/io oai?iao na?oey ( ION) c
aeenooieoei?th eiaiai oeoii/ea, a oiio /enei 109 /ieiaieia (85,2%) i 19
aeiiie (14,8%) o aioei aiae 43 aei 71 ?ieo. Eiio?ieueio a?oio neeaee 36
i?aeoe/ii caei?iaeo inia aiaeiai/iiai aieo oa noaoi.

Noai oai?eo ioeiithaaany ia iiaenoaai aeaieo
eeiiiei-ooieoeiiiaeueiiai ianoaaeaiiy, ui ioiiethaaei ?acoeueoaoe
oiceeaeueieo, oa?aiaaoe/iiai, aiioiii/ieo oa iino?oiaioaeueieo
aeineiaeaeaiue.

Iaoei?ioe ianoaaeoaaeeny a?aioei, iaoua, iiney 20-30 oaeeei
aiae-ii/eieo. O anio oai?eo i?iaiaeeee caai? e?iai c vena cubitalis aeey
aiioiii/ieo aiaeicia. A e?iai aeineiaeaeoaaeeny iieacieee noaio
?aiiiaiaiioaiceiaeueaeinoa?iiiai? nenoaie (RAS), eiioeaio?aoeiy
aeaeo?ie?oia. Aeiaaiinoeeo a?eoiie oa aa?ioieaoeith oa?aeoa?o ii?ooaiue
?eoio i?iaiaeeee ia iniiai AEA-aeineiaeaeaiiy. Aeiaiaa iiiioi?oaaiiy AEA
cae?enithaaee ca aeiiiiiaith nenoaie aeey aeeiaii/ii?
aeaeo?iea?aeiia?aoi? “Eaioa-IO.”

Aiaeicoth/e AEA, iiae?aoiaoaaee eieueeinoue aeno?anenoie ca
eiaeio aiaeeio ?a?no?aoei? i ca 24 aiaeeie. I?e ioeiioei
i?ioeaia?eoii/ieo aoaeoia i?aia?aoia aecia/aee aiaenioie cieaeaiiy /enea
aeno?aneoie i?e aeiaiaiio eiio?iei.

Oeueo?acaoeiaa aeineiaeaeaiiy aeeiioaaee ia aia?aoi a
aeaiii?iiio oa I-?aaeeii c ?iai/ith /anoioith oeueo?acaoea 3iAoe i
eooii neaioaaiiy 80` c ia?anoa?iaeueii? oa aiieaeueii? iiceoei? ca
noaiaea?oiith iaoiaeeeith. Aeey ioeiiee noaio ea?aeiiaaiiaeeiaiiee
aecia/aeeny oaei iieacieee: eioeaaee aeianoiei/iee ?ici?? eiaiai
oeoii/ea (EAe?), eiioeaaee nenoiei/iee ?ici?? eiaiai oeoii/ea (EN?),
nooi?iue nei?i/aiiy ia?aaeiuei-caaeiueiai ?icii?o eiaiai oeoii/ea a
nenoieo (% (S), eiioeaaee aeianoie?/iee ia’?i eiaiai oeoii/ea
(EAeI), eiioeaaee nenoiei/iee ia’?i eiaiai oeoii/ea (ENI), oaea?iee
ia’?i (OI), o?aeoeith aeeeaeo (OA), oaeaeeinoue oee?eoey?iiai nei?i/aiiy
aieieii iiiea?aea (V cf), iano iiiea?aea eiaiai oeoii/ea (IIEO ).

Oao?aiiey?ia a?oaeia ?aia?aoiy i?iaiaeeeany ca aeiiiiiaith
i?eno?ith ?IA2-02 ca caaaeueiii?eeiyoith iaoiaeeeith. Aiaeicoth/e
?ai-a?aiio, aecia/aee oaei iieacieee: oaea?iee ia’?i (OI) oa oaeeeiiee
ia’?i (OI) na?oey , caaaeueiee ia?eoa?i/iee noaeeiiee iii? (CINI).

Aaeia?aiiao?iy i?iaiaeeeany ia i?eno?i? “Niiain-Aeaia”.
Canoiniaoaaeany iaoiaeeea c na?i?th iaaaioaaeaiue ic nooiii/anoei
caieueoaiiyi iiooaeiinoi. O?eaaeinoue eiaeiiai ianooiiiai nooiaiy
iaaaioaaeaiiy — 3 oaeeeie; ii/aoeiaa iaaaioaaeaiiy 25 Ao, ia eiaeiiio
ianooiiiio nooiaii iioaineaiinoue iaaaioaaeaiiy caieueooaaeanue ia 25
Ao. A ii/aoeiaiio noaii oa a eiioei eiaeiiai nooiaiy iaaaioaaeaiiy
aecia/aany a?oa?iaeueiee oene (AO), caienoaaeany AEA a 12
caaaeueiii?eeiyoeo aiaeaaaeaiiyo.

Noai (RAS) ioeiithaaany ca aeiiiiiaith ?aaeiiiioiieo iaoiaeia
aeineiaeaeaiiy: ?iaiy aeueaeinoa?iio (A), aiaiioaiceio I (AI),
aiaiioai-ceio II (AII) a ieacii e?iai, aeoeaiinoi ?aiiio ieacie e?iai
(A?I) c aeei?enoaiiyi noaiaea?oieo EIO iaai?ia. Eiioeaio?aoeith
aeaeo?ie?oia a ieacii e?iai aecia/aee ca aeiiiiiaith iaoiaea iieoi’yii?
oioiiao?i? ia iieoi’yiiio aiaeicaoi?i IAAE-2.

Noaoenoe/ia ia?iaea ?acoeueoaoia i?iaiaeeeany ca
caaaeueiii?eeiyoei iaoiaeii aa?iaoeieii? noaoenoeee (I.Aaeei,
Ae.Naiaoei?a) ia ?N ?AI.

?acoeueoaoe aeineiaeaeaiiy oa ?o aiaeic

I?e aeineiaeaeaiii eeii?/ii? aoaeoeaiinoi IAIO ianoaaeaii 64
oai?eo ia ION c aeenooieoei?th eiaiai oeoii/ea (EO) oa ii?ooaiiyie
na?oeaaiai ?eoio (IN?). Ooieoeiiiaeueii iiaeeeainoi iaoei?ioia c
o?iii/iith na?oeaaith iaaeinoaoiinoth (ONI), caiaeii ic eeaneoieaoei?th
Iueth-Ei?enueei? Anioeiaoe?? na?oey (NYHA), aoee oaeeie: I OE-o 26
oai?eo; II OE-o 25 oai?eo; III-IV OE o 13 oai?eo. Ca aeaieie
oieoa?ianueeiai iiiioi?oaaiiy AEA, caiaeii c nenoaiith a?aaeaoeie OA ii
A. Lawn, oai?i aoee ?iciiaeieaii oaeei /eiii: 1a?aaeaoei? — o 21; 2
a?aaeaoei?- o 23; 3 i 4 a?aaeaoei? — o 20 oai?eo. I?ioyaii 12 oeaeiia
oai?ei i?ecia/aee ?aiioae a aeici 2,5-20ia ia aeiao. Ia oiii oa?aii?
niinoa?iaaeany iiceoeaia eeii?/ia aeeiaiiea o 53 iaoei?ioia ( 82,8%). O
oeeo oai?eo aiaecia/aeiny ciaioaiiy caaeeoee, iaa?yeia, canoieieo yaeu a
eaaaiyo, iie?auaiiy aeeiiaiiy cae/aeieo iianyeaeaiieo oice/ieo
iaaaioaaeaiue. Iai?eeiioei eieoaaiiy ooieoeiiiaeueii iiaeeeainoi onio
iaoei?ioia aiaeiiaiaeaee I-II OE . Ii?yae c iie?auaiiyi oice/ieo
iiaeeeainoae o 19 (35,8%) oai?eo niinoa?iaaeiny ciaioaiiy eieueeinoi OA
c 6898(933 aei 4012(569 ia aeiao. I?e iayai ia?ieo OA, ianoieei?
oeoii/eiai? oaoiea?aei? (oai?i III-IV OE) IAIO ni?eyee ?o ii?iaeoaaiith
o 9 oai?eo (45%).

Oaeei /eiii, i?ecia/aiiy ?aiioaeo ia oiii noaiaea?oii? oa?aii?
i?ecaiaeeoue aei iie?auaiiy ooieoeiiiaeueieo iiaeeeainoae
na?oeaai-noaeeiii? nenoaie o aieueoinoi iaoei?ioia, ni?ey? ia?aoiaeo ONI
a ieae/ee ooieoeiiiaeueiee eean (NYHA) . Ii ii?i iie?auaiiy ooieoei?
iiiea?aea niinoa?iaa?oueny ciaioaiiy eieueeinoi OA.

Aeey aeineiaeaeaiiy aieeao IAIO ia RAS ianoaaeaii 84 oai?eo ia
ION c aeenooieoei?th EO oa a?eoiiyie. Eieoaaiiy ?aiioaeii i?iaiaeeee
aiaee?eoei caniaii, aac i?ecia/aiiy ieaoeaai, i?e aaeaeaaoiie
aaiiaeeiaii/iie ?aaeoei? o aiaeiiaiaeue ia i?iaio aeico 2,5ia .
O?eaaeinoue eieoaaiiy neeaea 8 oeaeiia. 1-o eiio?ieueio a?oio neeaee 16
oai?eo ia ION c ONI I-II OE aac ii?ooaiue na?oeaaiai ?eoio; 2-o
-34oai?eo ia ION c ONI I-II OE oa OA 1-ai eeano (B.Lawn); 3-th a?oio
neeaee 31 iaoei?io, II OE c OA 2-ai eeano (B.Lawn); 4-o a?oio neeaee 19
oai?eo, III OE,

OA 2-3 eeania. Iieacieee ?iaiy A?I, AII, ALD iaaaaeaii a
oaaeeoei 1.

Oaaeeoey 1

??aaiue aeoeaiino? ?ai?io ieacie, aeueaeinoa?iio, aia?ioaiceio II, ai?no
aeaeo?ie?o?a eae?y ? iao??y a ieaci? e?ia? a aeeiai?oe? e?eoaaiiy
?ai?oaeii

Iieacieee

Noaae?? niinoa?aaeai-iy A?oie oai?eo

1-a

a?oia 2-a

a?oia 3-a

a?oia 4-a a?oia

Aeoeai?noue ?ai?io ieacie (A?I),

ia/ie//-1

Aei e?eoaaiiy 3.58(0.9 4.19(1.05 5.72(1.16 8.06(1.19

P>0.05 P>0.05 P<0.05 I?ney e?eoaaiiy 6.12(0.83 7.39(1.19 9.35(1.29 12.31(1.4 P1>0.05 P1<0.05 P1<0.05 P2<0.05 P2<0.05 P2<0.05 P2<0.05 Aeueaeinoa?ii (ALD), ia/ie Aei e?eoaaiiy 312.9(41.8 331.4(41.6 308.6(51.7 199.1(33.4 P>0.05 P>0.05 P>0.05

I?ney

e?eoaaiiy 197.4(23.1 202.3(33.8 181.9(25.8 123.4(15.9

P1>0.05 P1>0.05 P1<0.05 P2<0.05 P2<0.05 P2<0.05 P2<0.05 Aia?ioaicei II ia/ie Aei e?eoaaiiy 16.4(2.12 17.9(2.3 20.30(3.6 24.1(4.0 P>0.05 P>0.05 P>0.05

I?ney

e?eoaaiiy 10.86(1.82 11.03(2.1 12.11(1.9 13.8(2.2

P1>0.05 P1>0.05 P1>0.05

P2<0.05 P2<0.05 P2<0.05 P2<0.05 Iao??e, iiieue/e Aei e?eoaaiiy 139.8(3.11 144.6(4.1 133.5(2.6 129.56(3.4 P>0.05 P>0.05 P>0.05

I?ney

e?eoaaiiy 131.6(2.1 142.9(3.84 130.1(2.86 128.8(1.96

P1>0.05 P1>0.05 P1>0.05

P2>0.05 P2>0.05 P2>0.05 P2>0.05

Eae?e,

iiieue/e

Aei e?eoaaiiy 4.03(0.29 4.11(0.18 3.46(0.31 3.21(0.10

P>0.05 P>0.05 P<0.05 I?ney e?eoaaiiy 4.29(0.19 4.19(0.23 3.64(0.15 4.12(0.14 P1>0.05 P1>0.05 P1>0.05

P2>0.05 P2>0.05 P2>0.05 P2<0.05 I?ei?oea aei oaaeeoe? 1 : P – aeinoia??i?noue a?aei?ie iieaciee?a a ii??aiyii? c eiio?ieueiith a?oiith aei e?eoaaiiy; P1 - aeinoia??i?noue a?aei?ie iieaciee?a a ii??aiyii? c eiio?ieueiith a?oiith i?ney e?eoaaiiy; P2 - aeinoia??i?noue a?aei?ie iieaciee?a ii a?oiao aei ? i?ney e?eoaaiiy. Iiney 8-oeaeiaaiai eieoaaiiy ?aiioaeii a onio a?oiao ianoaaeaieo oai?eo niinoa?iaaany c?ino A?I ia oei cieaeaiiy ?iaiy AII oa ALD. Neiae iiaee?aneeoe, ui ?icieoey oe?o iieacieeia a a?oiao aei i iiney eieoaaiiy ? noaoenoe/ii aeinoiai?iith (oaae.1). A oie aea /an aiino aeaeo?ie?oia a ieacii e?iai cia/eii ia ciiieany aii a 1-e, aii a 2-e, aii a 3-e a?oiao. A 4-e a?oii oai?eo c iaeaieueo ae?aaeaiith aeenooieoei?th eiaiai oeoii/ea oa OA aeniei? a?aaeaoei? aiino eae?th a ieacii e?iai c?in, a ?iaaiue iao??th noaoenoe/ii cia/eii ia ciiieany. I?e ii?iaiyiii c iieacieeaie eiio?ieueii? a?oie iiney eieoaaiiy A?I aoea aeinoiai?ii aeuith a 3-e i a 4-e a?oiao. Ii?yae c oeei, a 4-e a?oii aiino ALD a ieacii e?iai aoa cia/eii ieae/ei, iiae a 1-e a?oii. ?icaia iioeo iieacieeia a ii?iaiyiii c eiio?ieueiith a?oiith aoa noaoenoe/ii iaaeinoiai?iei. Eieueeinoue OA a 2-e a?oii ciaioeeany ia 23.85 %; a 3-e - ia 36,55 %; a 4-e -ia 38,4%. Cieaeaiiy eieueeinoi OA ia noi?iaiaeaeoaaeiny ciaioaiiyi nooiaiy ?o a?aaeaoei?, ca aeeeth/aiiyi oai?eo 4-? a?oie, aea OA iiney eieoaaiiy iiaeia aoei aiaeianoe ia aei 3-ai, a aei 2-ai eeano. sse iiaeia aa/eoe, onoiaiiy aiiieaei?ii? ia oii? eieoaaiiy ?aiioaeii ni?eyei cieeiaiith iieiii?oieo OA. Oaeei /eiii, iae?iaoii?aeueii ciiie ia oei eieoaaiiy IAIO, coiiaeaii cieaeaiiyi ieaciiaiai ?iaiy AII, onoiaiiyi aiiieaei?ii? (iaeaieueo iiiioii a 4-e a?oii) ni?eythoue ciaioaiith eieueeinoi OA, a ie?aieo aeiaaeeao ci ciaioaiiyi ?o a?aaeaoei(. I?e aeineiaeaeaiii ea?aeiiaaiiaeeiaii/ii? aoaeoeaiinoi IAIO ianoaaeaii 59 oai?eo ia ION, ye? aoee ?iciiaeieaii ia 3 a?oie: 1 a?oia- 16 oai?eo ia ION ?c ONI I OE i 16 oai?eo ia ION ?c ONI II OE, onueiai 32 iniae c OA 1-? a?aaeaoei?; 2-a?oia- 13 oai?eo ia ION (ONI I OE- 3 iniae, II OE-9 inia, III OE-2 iniae) c OA 2-? a?aaeaoei?; 3 a?oia-12 oai?eo (ONI II OE-3 iniae, III OE-9 inia) c OA 3-? a?aaeaoei?. Nii/aoeo aeica ?aiioaeo neeaaeaea 2,5 ia ia aeiao, caiaeii aeico iiaeaeuoaaee aei 20 ia. O?eaaeinoue eieoaaiiy neeaaeaea 6 oeaeiia. Ianeiaeee aoiea?aeiia?aoi/iiai aeineiaeaeaiiy oa oieoa?ianueeiai iiiioi?oaaiiy AEA aiaeia?aaeaii a oaae. 2 . Oaaeeoey 2 Aeai? aoiea?ae?ia?ao?/iiai aeine?aeaeaiiy ? aeiaiaiai iii?oi?oaaiiy o oai?eo c OA a aeeiai?oe? e?eoaaiiy ?ai?oaeii Iieacieee Cia/aiiy iieaciee?a P Aei e?eoaaiiy I?ney e?eoaaiiy 1-a a?oia AOn, ii ?o.no. 139.4(5.2 123.1(4.3 <0.05 AOae, ii ?o.no. 84.9(4.8 79.0(5.3 >0.05

EN?, ni 4.24(0.18 3.7(0.16 <0.05 EAe?, ni 5.41(0.31 5.11(0.29 >0.05

ENI, ni( 79.4(2.0 59.8(1.95 <0.05 EAeI, ni3 142.5(6.8 123.9(4.9 <0.05 OI, ni3 63.3(4.1 64.6(5.7 >0.05

OA, % 44.2(2.0 52.33(3.4 <0.05 %(S, % 21.6(1.2 27.45(1.3 <0.05 Vcf, n-1 0.72(0.03 0.94(0.04 <0.05 CINI, aeei/n/ni-5 1810.34(131.2 1629.81(142.4 >0.05

*anoioa OA ia aeiao 648(94 405(72 <0.05 I?iaeiaaeaiiy oaaeeoe? 2 2-a a?oia AOn, ii ?o.no. 143.4(5.1 128.6(4.9 <0.05 AOae, ii ?o.no. 88.3(3.9 72.2(2.8 <0.05 EN?, ni 5.10(0.20 4.28(0.19 <0.05 EAe?, ni 6.25(0.31 5.59(0.26 >0.05

ENI, ni3 123.16(11.40 81.3(8.9 <0.05 EAeI, ni3 196.8(12.1 155.6(11.9 <0.05 OI, ni3 73.1(3.2 75.8(4.6 >0.05

OA, % 40.3(1.6 49.40(2.3 <0.05 %(S, % 18.4(1.2 23.30(1.3 <0.05 Vcf, n-1 0.76(0.04 0.98(0.05 <0.05 CINI, aeei/n/ni-5 1894.50(158.4 1481.90(138.6 >0.05

*anoioa OA ia aeiao 10508(938 6095(827 <0.05 3-y a?oia AOn, ii ?o.no. 144.9(7.3 121.5(6.9 <0.05 AOae, ii ?o.no. 89.6(3.6 76.8(3.2 >0.05

EN?, ni 5.28(0.30 4.5(0.10 <0.05 I?iaeiaaeaiiy oaaeeoe? 2 EAe?, ni 6.21(0.24 5.81(0.12 >0.05

ENI, ni3 129.3(10.6 97.5(9.8 <0.05 EAeI, ni3 194.1(13.4 166.9(12.1 >0.05

OI, ni3 65.8(3.5 69.6(3.8 >0.05

OA, % 34.6(1.98 41.57(2.13 <0.05 %(S, % 16.1(1.1 21.17(1.3 <0.05 Vcf, n-1 0.67(0.01 0.79(0.02 <0.05 CINI,aeei/n/ni-5 1915.60(121.4 1580.35(129.0 >0.05

*anoioa OA ia aeiao 11901(1011 7228(986 <0.05 Ia oei eieoaaiiy ?aiioaeii a 1-e a?oii oai?eo aeinoiai?ii cieaeothoueny ?icii?e oa ia’?ie ii?iaeiei EO a nenoieo EN? oa EAeI i?e iaeii/aniaiio caieueoaii? OA, nooi?iue nei?i/aiiy ia?aaeiuei-caaeiueiai ?icii?o EO a nenoieo ( % ( S ) i oaeaeeinoue oee?eoey?iiai nei?i/aiiy aieieii iiiea?aea ( Vnf ) .Ia aiaeii/aii cia/iiai cieaeaiiy EAe? i ENI, iaei ciiieany OI. Ia niinoa?iaaeiny aeinoiai?iiai cieaeaiiy AO i CINI ( ?(0,05). Cia/eii ciecany AOn , i?e oeueiio ciaiooaaeanue /anoioa OA ( oaae. 2 ). O oai?eo 2-? a?oie aeeiaiiea aoiea?aeiia?aoi/ieo iieacieeia aoea aiaeiai/iith. Aea caa?oa? ia naaa oaaao noaoenoe/ii aeinoiai?ia cieaeaiiy AOn, AOae i, ui iaeaieueo aaaeeeai, CINI. Aeeiaiiea cieaeaiiy /anoioe OA oaeiae aoea aieueo iiiioiith ( oaae. 2 ). A 3-e a?oii ciiie ?icii?ia i ia’?iia ii?iaeiei EO ( ca aeeeth/aiiyi EAeI ) aoee noaoe/ii aeinoiai?ieie ( ?(0,05 ). C?inoaiiy OI aoei iacia/iei ( ?(0,05 ), OA, Vnf oa %(S cia/ii caieueoeeenue, a AOn, AOae i CINI noaoe/ii aeinoiai?ii cieceeenue (?(0,05 ). Eieueeinoue OA ciaioeeanue. Oaeei /eiii, neiae iiaee?aneeoe, ui iie?auaiiy iieacieeia, yei oa?aeoa?icothoue noai nei?i/oaaeueii? ooieoei? iiiea?aea, noi?iaiaeaeo?oueny i cieaeaiiyi /enea OA. Aeeiaiiea ciii iieacieeia AoiAA oa /anoioe OA iiiioiioa o inia c ONI aeuiai OE. Aeey ioeiiee aieeao oa?aii? IAIO ia oiea?aioiinoue aei oice/iiai iaaaioaaeaiiy oai?ei 1-? a?oie i?iaaaeaii oano ia aaeia?aiiao?i aei i iiney eieoaaiiy ?aiioaeii. I?iao i?iaaee 19 oai?ei, c ieo o 8 OA ia ?a?no?oaaeeny. Aei eieoaaiiy ?aiioaeii oano ic oice/iei iaaaioaaeaiiyi aoa iiceoeaiei o 14 oai?eo (73,6%), OA aoee ni?iaieiaaii o 6 c 8 oai?eo, aoii o 3-o c ieo ia AEA aiaecia/aeany i aeai?aniy naaiaioo ST. Aaee/eia ii?iaiaiai iaaaioaaeaiiy aei eieoaaiiy neeaea 35,3(2,1 Ao, a caaaeueiee ia’?i aeeiiaii? ?iaioe - 1450,1(148,4 eai. Iiney i?iaaaeaii? oa?aii? oano ia aaeia?aiiao?i aeyaeany iiceoeaiei o 12 oai?eo (63,2%), OA ia oiii i?iae aeyaeeany o 3-o oai?eo, a o iaeiiai ?a?no?oaaeany aeai?aniy naaiaioo ST. I?e oeueiio aaee/eia ii?iaiaiai iaaaioaaeaiiy caieueoeeanue aei 49,8(3,01 Ao, a caaaeueiee ia’?i aeeiiaii? ?iaioe caieueoeany aei 2118,8(151,4 eai. ?icieoey a ii?iaiyiii c oeeie iieacieeaie aei eieoaaiiy ? noaoenoe/ii aeinoiai?iith. Oea naiae/eoue i?i oa, ui iiceoeaii ea?- aeiiaaiiaeeiaii/ii ciiie ia oei eieoaaiiy IAIO ni?eythoue ia oieueee ciaioaiith eieueeinoi OA, aea e c?inoaiith oiea?aioiinoi aei oice/iiai iaaaioaaeaiiy. Ia iaoo aeoieo, i?aaenoaaeyeiny oeieaaei aeineiaeaeaiiy aieeao o?eaaei? oa?aii? ?aiioaeii ia iieacieee aaiiaeeiaiiee oa /anoioo OA, aeey /iai ianoaaeaii 34 oai?eo c ONI I-II OE oa OA 1-? a?aaeaoei?. Eieoaaiiy ?aiioaeii i?iaiaeeee i?ioyaii 10 iinyoeia o aeici 2,5 -20 ia ia aeiao. Ii?yae c iieacieeaie ea?aeiiaaiiaeeiaiiee aecia/aee iano iiiea?aea EO (IIEO). Aaee/eie iieacieeia ii?iaithaaee aei oa iiney eieoaaiiy. ?acoeueoaoe aeineiaeaeaiiy aiaeia?aaeaii a oaaeeoei 3. sse iiaeia aa/eoe, i?e o?eaaeiio i?ecia/aiii ?aiioaea cia/ia ciaioaiiy eieueeinoi OA aiaeaoaa?oueny ia oieueee ia oei iie?auaiiy iieacieeia ea?aeiiaaiiaeeiaiiee, aea e i?e cia/iiio ciaioaiii IIEO. Ii?yae c oeei, ca i?eioeeiii cai?ioiiai ca`yceo, ciaioaiiy eieueeinoi OA nooo?ai iaiaaeo? iaaaoeaiee aieea oeoii/eiaeo aeoiiie ia aaiiaeeiaii/ii iieacieee i nei?i/oaaeueio ooieoeith iiiea?aea. Oaaeeoey 3 Iieacieee aaiiaeeiai?ee, aioo??na?oeaai? e?iaoeee oa nei?i/oaaeueii? ooieoe?? i?iea?aea i?e o?eaaeiio e?eoaaii? ?ai?oaeii o oai?eo c aeenooieoe??th EO ? OA Iieacieee Cia/aiiy iieaciee?a P Aei e?eoaaiiy I?ney e?eoaaiiy AOn, ii ?o.no. 138.8(3.6 129.1(3.0 <0.05 AOae, ii ?o.no. 82.6(4.0 76.4(5.1 >0.05

OIAEIn ii 12.9(1.1 10.1(0.8 <0.05 OCNEOn ii 11.9(0.9 8.6(0.6 <0.05 EN?, ni 4.16(0.24 3.6(0.10 <0.05 EAe?, ni 5.40(0.20 5.18(0.12 >0.05

EAeI, ni3 142.0(6.1 129.0(5.9 >0.05

ENI, ni3 74.6(4.8 55.2(3.4 <0.05 OI, ni3 68.5(2.2 74.6(2.1 <0.05 OA, % 47.9(2.9 57.4(2.6 <0.05 %(S, % 24.1(1.3 31.4(1.8 <0.05 Vcf, n-1 0.75(0.04 0.96(0.05 <0.05 I?iaeiaaeaiiy oaaeeoe? 3 IIEO, a 155.54(4.8 143.12(3.4 <0.05 *anoioa OA ia aeiao 714,6(81 208,4(79 <0.05 E?ii iaaaaeaieo aeua aeineiaeaeaiue, iaie cai?iiiiiaaia iiaa noaia eieoaaiiy, yea ia?aaeaa/a? iaeii/aniaee i?eeii IAIO ?aiioaea oa aeieaoi?a ?aoeaioi??a aiaiioaiceia II eicaa?a . Ianoaaeaii 19 oai?eo. ?aiioae i?ecia/aee a aeici 20 ia ia aeiao, eicaa? - 50 ia ia aeiao. Iai?eeiioei eieoaaiiy EN? ciaioeany c 5,81(0,3 ni aei 4,87(0.24ni , ENI-c 166,8(12.3 ni3 aei 103,8(10.7ni3. OA iiaeaeueeanue c 32.5(1,9% aei 45,0(1,7% ; %(S c 15,94(1,4% aei 24,6(1,8% (p( 0,05); Vnf c 0,66(0,04 n-1 aei 0,82 ( 0.05 n-1.(Noaoenoe/ii aeinoiai?ii cieceany AOn oa AO ae, a CINI ciaioeany c 149592 ( 189 aeei /n/ ni-5 aei 12339(169 aeei/ n/ ni-5. Caiaeii c oanoii c 6-oe oaeeeiiith oiaeith , caieueoeeanue aeenoaioeiy , yeo i?ioiaeeee iaoei?ioe, c 339(56 i aei 516(68 i. Eieueeinoue OA ciaioeeanue c 9623(1100 aei 6134( 895. Oaeei /eiii, eiiaiiiaaia oa?aiiy IAIO ?aiioaeii i aeieaoi?ii ?aoeaioi??a AII eicaa?ii ni?ey? iie?auaiith iieacieeia ea?aeiiaaiiaeeiaiiee, caieueoo? oiea?aioiinoue aei oice/iiai iaaaioaaeaiiy, cieaeo? eieueeinoue OA. Oaea eiiaiiaoeiy na?aaeieeia ? ?aoeiiiaeueiith, yeui ie?aii i?ecia/aiiy IAIO aai aeieaoi?a ?aoeaioi??a AII aeyaeythoueny iaaeinoaoiuei aoaeoeaieie. Aeniiaee 1. I?ecia/aiiy IAIO ?aiioaea oai?ei c aeenooieoei?th eiaiai oeoii/ea oa oeoii/eiaeie a?eoiiyie i?ecaiaeeoue aei iie?auaiiy ooieoeiiiaeueieo iiaeeeainoae na?oeaai-noaeeiii? nenoaie, ni?ey? ia?aoiaeo o?ii?/ii? na?oeaai? iaaeinoaoiino? a ieae/ee ooieoeiiiaeueiee eean. Ii ii?i iie?auaiiy iiiea?aeiaeueii? ooieoei? niinoa?iaa?oueny ciaioaiiy eieueeinoi oeoii/eiaeo aeno?anenoie. 2. Iae?iaoii?aeueii ciiie ia oiii eieoaaiiy ?aiioaeii, coiiaeaii cieaeaiiyi ieaciiaiai ?iaiy aia?ioaiceio ??, aeueaeinoa?iio, iiaeaeuaiiyi aeoeaiino? ?ai?io ieacie, onoiaiiyi aiiieaei?ii?, ni?eythoue ii?iaeoaaiith oeoii/eiaeo aeno?anenoie i ciaioaiith ?o a?aaeaoei?. 3. Eieoaaiiy IAIO ?aiioaeii oai?eo c aeenooieoei?th e?aiai oeoii/ea aaaea aei iie?auaiiy iieacieeia, yei oa?aeoa?ecothoue noai nei?i/oaaeueii? ooieoei? iiiea?aea, aei iiaeaeuaiiy oiea?aioiinoi aei oice/iiai iaaaioaaeaiiy. Aeeiaiiea iie?auaiiy iieacieeia aoiea?aeiia?aoi? i cieaeaiiy /anoioe oeoii/eiaeo aeno?anenoie iiiioiioa o oai?eo c o?ii?/iith na?oeaaith iaaeinoaoi?noth aeuiai ooieoe?iiaeueiiai eeano. 4. O?eaaea oa?aiiy ?aiioaeii ni?ey? ciaioaiith aiia?o?ioi? iiiea?aea eiaiai oeoii/ea, iie?auo? iieacieee ea?aeiiaaiiaeeiaiiee, cieaeo? /anoioo oeoii/eiaeo ii?ooaiue ?eoio. 5. Niieo/aia i?ecia/aiiy IAIO ?aiioaea i aeieaoi?a ?aoeaioi??a aia?ioaiceio II eicaa?a o oai?eo c ae?aaeaiith aeenooieoei?th e?aiai oeoii/ea oa oeoii/eiaeie aeno?anenoieaie ni?ey? iie?auaiith nei?i/oaaeueii? ooieoei? iiiea?aea i c?inoaiith oiea?aioiinoi aei oice/iiai iaaaioaaeaiiy. Ia oiii noaaieicaoei? iieacieeia ea?aeiiaa-iiaeeiaiiee ciaioo?oueny eieueeinoue oeoii/eiaeo aeno?anenoie. Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe?? 1.I. A. Cae/aiei. Iaeioi?ua iaoaaiee/aneea yooaeou eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa o aieueiuo n aeenooieoeeae eaaiai aeaeoaei/ea e a?eoieyie. // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.-1997.- ?24.- N. 130 -133. 2.I.A. Cae/aiei. Eiaeaeoi?u aiaeioaiceii?aa?auathuaai oa?iaioa a ea?aeeieiaee. // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.-1998.- ? 17. -N. 28-31. 3.I.A. Cae/aiei. Iniaaiiinoe aeeyiey aeeeoaeueiiai ea/aiey ?aieoaeii ia ooieoeeiiaeueiia ninoiyiea ieiea?aea o aieueiuo n iaaeinoaoi/iinoueth e?iaiia?auaiey. // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.- 1998.- ?22.- N.89-91. 4.I.A. Cae/aiei. Eiaeaeoi?u aiaeioaiceii?aa?auathuaai oa?iaioa e aeenooieoeey eaaiai aeaeoaei/ea o aieueiuo eoaie/aneie aieaciueth na?aeoea. // Iaaeeoeeia naaiaeiy e caao?a. Ia?eiaee/aneee nai?iee iao/iuo ?aaio iieiaeuo o/aiuo e niaoeeaeenoia, a. 2: IIC Oe?aeiu , OAIO.- Oa?ueeia, 1997.- N.45-46. 5.I.A. Cae/aiei. Aeeyiea ?aieoaea ia ooieoeeiiaeueiia ninoiyiea ieiea?aea e ei?iia?iia e?iaiia?auaiea o aieueiuo n canoieiie na?aea/iie iaaeinoaoi/iinoueth e aeaeoaei/eiauie a?eoieyie. // ?anioaeeeaineay iao/ii-i?aeoe/aneay eiioa?aoeey iieiaeuo o/aiuo e niaoeeaeenoia “Nia?aiaiiua ooiaeaiaioaeueiua e i?eeeaaeiua i?iaeaiu eeeieee aioo?aiieo aieaciae”, oacenu, Oa?ueeia, 1997, n.38. 6. Eaoiaoc E.E., Eo/a?aiei I.Ae., Aaeiaie A.I., Noi?oi N.A., Cae/aiei I.A., Oaeaaeia I.Ae., Iiai?aeia A.I. Aioea?eoie/aneea e aaiiaeeiaie/aneea yooaeou ?aieoaea o aieueiuo n iaaeinoaoi/iinoueth e?iaiia?auaiey. // Aanoiee a?eoiieiaee.-?8.- N. 50.- ?191. 7. Eaoiaoc E.E., Iineaeaiei A.O. , Eo/a?aiei I.Ae. , Aaeiaie A. I., Noi?oi N.A., Oaeaaeia I.Ae., Cae/aiei I.A., Iiai?aeia A.I., A?ae A.A. Aeeyiea yiaeai?eea ia ea?aeeiaaiiaeeiaieeo o aieueiuo n aeenooieoeeae eaaiai aeaeoaei/ea.// OIV c’?cae oa?aiaaoia Oe?a?ie, Ee?a, 1998, oace aeiiiaiaeae, n . 54-55. 8. Eaoiaoc E.E., Eo/a?aiei I.Ae., Oaeaaeia I.Ae., Iineaeaiei A.O., Iiai?aeia A.I., A?ae A.A., Cae/aiei I.A., ss?ioaiei E. A., Noi?oi N.A. Eeeie/aneay e aaiiaeeiaie/aneay yooaeoeaiinoue eicaa?a o aieueiuo eoaie/aneie aieaciueth na?aeoea, a?oa?eaeueiie aeia?oiieae e aeaeoaei/eiaie yeno?anenoieeae. // Iaoa??aee II-? Oe?a?inueei? i?aeia?iaeii? eiioa?aioe?? c i?aeia?iaeiith o/anoth “Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??”. A?iieoey, 1998.- N.144. Aiioaoe?? Cae/aiei I.?. Ii??aiyeueia iaoaaie?/ia oa aaiiaeeiai?/ia aoaeoeai?noue ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo i?e aeenooieoe?? e?aiai oeoii/ea oa ii?ooaiiyo na?oeaaiai ?eoio.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11- ea?ae?ieia?y.- Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1998. A ?iaio? aea/aia iaoaaie?/ia oa aaiiaeeiaii/ia aoaeoeaiinoue iiaiaioi?ia aia?ioaiceiia?aoai?thth/iai oa?iaioo (?AIO) o oai?eo c aeenooieoei?th eiaiai oeoii/ea oa a?eoiiyie. Aeyaeaii iniaeeainoi iae?iaoii?aeueieo ii?ooaiue; aecia/aii iaeaieueo ?aoeiiiaeueii oeyoe ei?aeoei? ca aeiiiiiaith ?AIO. Iieacaii, ui iiae aieeaii oa?aii? ?AIO o oai?eo c aeenooieoei?th e?aiai oeoii/ea ia oei ii?iaeicaoei? iae?iaoii?aeueiiai noaio oa iieiioaiiy ea?aeiiaaiiaeeiaii/ieo iieacieeia cia/ii cieaeo?oueny /anoioa oeoii/eiaeo aeno?anenoie oa ciaioo?oueny ?o a?aaeaoe?y. Anoaiiaeaii, ui o?eaaea oa?aiiy IAIO ni?ey? ?aa?ani? aiia?o?ioi? iiiea?aea eiaiai oeoii/ea, ciaioaiith eieueeino? oeoii/eiaeo aeno?anenoie. Cai?iiiiiaaia eiiaiiiaaia oa?aiiy IAIO ?aiioaeii oa aeieaoi?ii ?aoeaioi?ia aiaiioaiceio II eicaa?ii. Eeth/ia? neiaa: ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo, ii?ooaiiy ?eoio, e?aee oeoii/ae, aeenooieoe?y, ?ai?oae. Cae/aiei I.A. N?aaieoaeueiay iaoaaiee/aneay e aaiiaeeiaie/aneay yooaeoeaiinoue eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa i?e aeenooieoeee eaaiai aeaeoaei/ea e ia?ooaieyo na?aea/iiai ?eoia.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11- ea?aeeieiaey.- Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1998. A ?aaioa eco/aia iaoaaiee/aneay e aaiiaeeiaie/aneay yooaeoeaiinoue eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa (EAIO) o aieueiuo n aeenooieoeeae eaaiai aeaeoaei/ea e a?eoieyie. Auyaeaiu iniaaiiinoe iae?iaoii?aeueiuo ia?ooaiee, ii?aaeaeaiu iaeaieaa ?aoeeiiaeueiua iooe ei??aeoeee n iiiiuueth EAIO. Ianeaaeiaaii 128 aieueiuo eoaie/aneie aieaciueth na?aeoea n aeenooieoeeae eaaiai aeaeoaei/ea e aeaeoaei/eiauie yeno?anenoieaie. I?e eco/aiee eeeie/aneie yooaeoeaiinoe EAIO onoaiiaeaii, /oi ia oiia ea/aiey ?aieoaeii o aieueoeinoaa aieueiuo ioia/aaony iieiaeeoaeueiay eeeie/aneay aeeiaieea a aeaea oiaiueoaiey iaeuoee, ioaeia, canoieiuo yaeaiee a eaaeeo, oeo/oaiey ia?aiineiinoe iianaaeiaaiuo oece/aneeo iaa?ocie. Oeo/oaiea ooieoeeiiaeueiuo aiciiaeiinoae na?aea/ii-ninoaeenoie nenoaiu niinianoaoao ia?aoiaeo o?iie/aneie na?aea/iie iaaeinoaoi/iinoe a aieaa ieceee ooieoeeiiaeueiue eeann. I?e ioeaiea aeeyiey EAIO ia ?aiei-aiaeioaicei-aeueaeinoa?iiiaoth nenoaio e iaiai yeaeo?ieeoia onoaiiaeaii, /oi ii?iaeecaoeey iae?iaoii?aeueiiai noaoona e yeaeo?ieeoiiai aaeaina, iaoneiaeaiiay nieaeaieai ieaciaiiiai o?iaiy aiaeioaiceia ??, aeueaeinoa?iia, oaaee/aieai aeoeaiinoe ?aieia ieaciu, ono?aiaieai aeiieaeeaiee, niinianoaoao o?aaeaieth aeaeoaei/eiauo yeno?anenoie e oiaiueoaieth eo a?aaeaoeee. I?e eco/aiee ea?aeeiaaiiaeeiaie/aneie yooaeoeaiinoe eiaeaeoi?ia AIO onoaiiaeaii, /oi iieiaeeoaeueiay aeeiaieea iieacaoaeae, oa?aeoa-?ecothueo ninoiyiea nie?aoeoaeueiie ooieoeee ieiea?aea, oaaee/aiea o?aeoeee aua?ina, nii?iaiaeaeaaony o?aaeaieai /anoiou aeaeoaei/eiauo yeno?anenoie, oaaee/aieai oiea?aioiinoe e oec/aneie iaa?ocea. Iieacaii, /oi aeeeoaeueiay oa?aiey eiaeaeoi?aie AIO niinianoaoao ?aa?annee aeia?o?ioee ieiea?aea eaaiai aeaeoaei/ea, i /ai naeaeaoaeuenoaoao nieaeaiea iannu ieiea?aea eaaiai aeaeoaei/ea, oeo/oaieth iieacaoaeae aaiiaeeiaieee e nie?aoeoaeueiie ooieoeee na?aea/iie iuooeu, oiaiueoaieth eiee/anoaa aeaeoaei/eiauo yeno?anenoie. Eiiaeie?iaaiiay oa?aiey n eniieueciaaieai eiaeaeoi?a aiaeioaiceii?aa?auathuaai oa?iaioa ?aieoaea e aeieaoi?a ?aoeaioi?ia aiaeioaiceia ?? eicaa?a iaania/eaaao aeinoaoi/ii au?aaeaiiue eeeie/aneee yooaeo i?e iacia/aiee oai aieueiui, o eioi?uo eciee?iaaiiia i?eiaiaiea eiaeaeoi?ia AIO ia i?eaaei e aeaeaaiui ?acoeueoaoai. Naeaeaoaeuenoaii iieiaeeoaeueiiai aeeyiey ia aioo?ena?aea/ioth aaiiaeeiaieeo yaeythony oiaiueoaiea ?acia?ia iieinoe eaaiai aeaeoaei/ea a nenoieo, eiia/iiai nenoiee/aneiai iauaia n iaeiia?aiaiiui oaaee/aieai o?aeoeee aua?ina, noaiaie oei?i/aiey ia?aaeia-caaeiaai ?acia?a eaaiai aeaeoaei/ea a nenoieo, nei?inoe oee?eoey?iiai oei?i/aiey aieieii ieiea?aea. Ia oiia iieiaeeoaeueiuo ea?aeeiaaiiaeeiaie/aneeo naeaeaia oaaee/eaaaony oiea?aioiinoue e oece/aneie iaa?ocea, nieaeaaony /anoioa aeaeoaei/eiauo yeno?anenoie ca nooee ii aeaiiui oieoa?ianeiai iiieoi?e?iaaiey. Oaeei ia?acii, iieo/aiiua ?acoeueoaou naeaeaoaeuenoaotho i aeinoaoi/iie iaoaaiee/aneie e aaiiaeeiaie/aneie yooaeoeaiinoe eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa e oeaeaniia?aciinoe iacia/aiey yoeo i?aia?aoia aieueiui n aeenooieoeeae eaaiai aeaeoaei/ea e ia?ooaieyie na?aea/iiai ?eoia. A neo/aa iayooaeoeaiinoe eciee?iaaiiie oa?aiee EAIO aiciiaeii eiiaeie?iaaiiia i?eiaiaiea eiaeaeoi?a AIO ?aieoaea e aeieaoi?a ?aoeaioi?ia aiaeioaiceia ?? eicaa?a. Eeth/aaua neiaa: eiaeaeoi?u aiaeioaiceii?aa?auathuaai oa?iaioa, ia?ooaiey ?eoia, eaaue aeaeoaei/ae, aeenooieoeey, ?aieoae. Zaichenko O.E. Comperative metabolic and hemodynamic effec-tivicity of Angiotensin Converting Enzyme Inhibitors in the patients with disfunction of left ventricular and disturbances of cardiac rhythm.- Manuscript. Thesis for candidate degree of medical scienses in the speciality 14.01.11-cardiology.-Kharkov State Medical University, Kharkov, 1998. In this work was studied metabolic and hemodynamic effectivicity of Angiotensin Converting Enzyme (ACE) Inhibitors in the patients with arrhythmias. It was established spesialites of neurogumoral disturbances, was determinated the most racionalisation ways of correction using ACE Inhibitors. It was shown that under influence ACE Inhibitors therapy in patients with disfunction of left ventricular and arrhythmias on base of normalisation neurogumoral status frequency of ventricular arrhythmias is decreased and the graduation is decrease too. It was established that along time ACE Inhibitors therapy helps to regression of myocardial hyperthrophy of left ventricular, the quontity of ventricular extrasystols was decreased. It was advised the therapy with the ACE Inhibitor renitec and blocator of angiotensin II receptors cozaar. Key words: Angiotensin Converting Enzyme Inhibitors, left ventricular, disturbances of cardiac rhythm, disfunction, renitek. I?aeienaii aei ae?oeo 24.12.98. Oi?iao 60 o 84/16. Iai?? ae?oea?nueeee. Oe?aae 100 i?ei??iee?a. Caiiaeaiiy ? 179. Iaae?oeiaaii ia ?ecia?ao? OIA “A??a”. 310002, i.Oa?e?a, aoe. Iooe?inueea 58a. PAGE 18

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