20

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao

?i. N. ?. Aai?a??anueeiai

I???ae???e Ieueaa Ay/aneaa?aia

OAeE 616.342-002.44:615.243

Ii??aiyeueia ee?i?/ia aoaeoeai?noue aeayeeo no/anieo i?aia?ao?a o
e?eoaaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee

14.01.02 — aioo??oi? oai?iae

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

N?ioa?iiieue — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i. aeaaeai?ea
I.I.Aiaiiieueoey ia eaoaae?? oaeoeueoaonueei? oa?ai?? ? 2.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? A?eoi? A?eai?iae/
Eeciaoa — caa?aeoth/ee eaoaae?ith oaeoeueoaonueei? oa?ai?? ?2
Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Aiaoie?e Noai?neaaiae/ Na?ioeeoeeee,
caa?aeoth/ee eaoaae?ith aini?oaeueii? oa?ai?? ?2 Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. I.I.Aiaiiieueoey

aeieoi? iaaee/ieo iaoe, i?ioani? Ieeiea Iie?ea?iiae/ Aoaeae,
caa?aeoth/ee eaoaae?ith oa?ai?? ?1 oa aano?iaioa?ieia?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe E?einueeiai aea?aeaaiiai oi?aa?neoaoo ?i.
N.?.Aai?a??anueeiai.

I?ia?aeia onoaiiaa: ?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y.

Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo aano?iaioa?ieia?? IIC Oe?a?ie.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 20 ea?oiy 1999 ?. i 14 aiae. ia
can?aeaii? Niaoe?ae?ciaaii? a/aii? ?aaee E 56.600.01 E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?.Aai?a??anueeiai (333006,
i.N?ioa?iiieue, aoe. Eai?ia, 5/7).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?.Aai?a??anueeiai.

Aaoi?aoa?ao ?ic?neaiee 18 aa?aciy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe, i?ioani?
I.O.Iaco?aoeue

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie aeine?aeaeaiiy. Ae?aceiaa oai?iaa, iniaeeai
oeeaoeeie aeaaiaaeoeyoeiaei? eeoee i?iaeiaaeo? caeeoaoeny aeoaea
?iciianthaeaeaiei caoai?thaaiiyi, ia yea ca?aeii c aeaieie a?o/eciyieo
oa ca?oa?aeieo a/aieo i?ioyaii aeeooy no?aaeaea? 10-20% aei?ineiai
ianaeaiiy [A.A.Eiia?ia, 1995; I.ss.Aaaae, A.Ae.Oaae??iei, 1997;
R.L.Rushworth, J.I.Westdrook, 1993; P.Sipponen, 1995]. Oai??thoue ia
ae?aceiao oai?iao a iniiaiiio iieiae? oa ethaee na?aaeiueiai a?eo, ?
oiio nioe?aeueia cia/ei?noue i?iaeaie iaaecae/aeii aeniea [A.Sonnenberg,
1995; E.?.A?o?i, 1998]. A inoaii? aeanyoe??//y ??cei ci?ieeenue aeoeaioe
uiaei aei ?yaeo ao?ieia?/ieo oa iaoiaaiaoe/ieo /eiiee?a ae?aceiai?
oai?iae oa ?o ?ie? ye o aeieeiaii? oai?iae, oae ? aeaeoaeaii? a?ae ia?
[I.ss.A?eai?’?a, 1996; E.?.A?o?i oa ni?aaao., 1998; A.?.Caeoeaa, 1998;
G.N.Tytgat, 1997].

Aaaaoi a /iio ci?ieeeny iiaeyaee ia ae?aaiinoeeo, e?eoaaiiy ?
iiaeeeaino? aee?eoaaiiy iaioe/ieo ae?acie [N.I.Oea/, 1998; G.D.Bell at
all, 1995; F.Bazzol at all, 1996], a oaeiae ia i?noea eeneioicieaeoth/eo
i?aia?ao?a, ?o ii?aeiaiiy c ?ioeie caniaaie: niaciie?oeeaie,
?aia?aioaie, aioea?ioeeaie oa ?ioeie o e?eoaaii? oai?eo ia ae?aceiao
oai?iao [I.ss.A?eai?’?a oa ni?aaao., 1995; O.E.Eaieia oa ni?aaao., 1995;
A.E.A?aaai?a oa ni?aaao., 1996;G.D.Bell, J.M.Gotz at all, 1995].

Iiaeyaee a/aieo ia ?ieue eeneioiino? oa ?ioaeoe?? o aeieeiaii? ye naii?
ae?acee, oae ? ?? aaaaoi/eneaiieo oneeaaeiaiue oa iiaeeeaino?
?aoeeaeoaaiiy iiee aeineoue noia?a/eea? oa iaiaeiicia/i?
[E.A.Eoae?yaoeaaa, 1998; G.D.Bell, 1996; T.Shimizu at all, 1996;
M.Rovizza at all, 1998]. Ca?aene ? aaeeea e?euee?noue niinia?a
ae?aaiinoeee oa cania?a e?eoaaiiy ? i?io?eaeoeee iaoneeaaeiaii?
ae?aceiai? oai?iae, yea anioe?th?oueny c Helicobacter pylori, a oiio
/ene? ? o??o?a?/ieo [A.A.Aoae??a oa ni?aaao., 1995; E.I.Iia/ai, 1997;
ss.N.Oeeiia?iai, 1998; L.Deodhar, 1996].

Aea a?eueo?noue a/aieo, iniaeeai a ?a?ii?, NOA, Eaiaae? ? Aano?ae??
noeey?oueny aei aeoiee, ui no?eea ?oaoethaaiiy ae?aceiaiai aeaoaeoo
iiaeeeaa eeoa a ?acoeueoao? cieaeaiiy eeneioii?iaeoeoe?? oeoiea oa
a?aaeeeaoe?? oae?eiaaeoa?ii? ?ioaeoe?? [F.Lanza et all, 1996; A.H.Soll,
1996, A.Axon, D.Forman, 1997], ? i?iiiiothoue aeey oe??? iaoe ??ci?
ii?aeiaiiy aioenae?aoi?ieo oa aioeaaeoa??aeueieo i?aia?ao?a [A.N.Eia?iia
oa ni?aaao., 1995; A.Axon at all, 1997; P.Malfertheiner at all, 1997].

Ana a?eueoa aeine?aeiee?a ieoooue i?i iiaeeea?noue aee?eiaoaaiiy
iaoneeaaeiaii? aeoiaeaiaeueii? ae?acee [E.?.A?o?i, 1998; A.?.Caeoeaaa,
1998; M.Buckley at all, 1997] ? iathoue ia oaac? i?e oeueiio
?oaoethaaiiy ae?aceiaiai aeaoaeoo, a?aaeeeaoe?th Helicobacter pylori oa
a?aenooi?noue caaino?aiue i?ioyaii ye iaeiaioa 1 ?ieo [A.?.Caeoeaaa,
1998; H.X.Xia, N.J.Talley, 1996; P.Michetti at all, 1996].

Oei a?eueoa o a?o/eciyi?e e?oa?aoo?? ? i?aeoeoe? iaa?oue inoaii?o ?ie?a,
ie aa/eii o e?eoaaii? a iniiaiiio o?aaeeoe?eiee i?aeo?ae, yeee iniiaaiee
ia oiio, ui “ae?aceiaa oai?iaa ? o?ii?/iith ?aoeeaeeaoth/ith oai?iaith c
i?ia?anoth/ei ia?aa?aii oa aeieeiaiiyi aaaaoi/eneaiieo oneeaaeiaiue o
oai?iai” [?.?.Aeaaoy?ueiaa, I.A.Oa?/aiei, 1995; E.I.Iia/ai, 1997].

O a?o/eciyi?e e?oa?aoo?? ie ia cono??ee ?iaioe ii aea/aiith iaeaeeae/eo
oa a?aeaeaeaieo ?acoeueoao?a ae?aaiinoeee oe?iiino? “aeeoaeueiiai” oanoo
ee?i?/ii? aoaeoeaiino?, oaeaeeino? ?oaoethaaiiy ae?aceiaeo aeaoaeo?a,
iiiiaeaiiy ii?ooaieo iieaciee?a ?ioi?oaoo oa ciaioaiiy e?eueeino?
?aoeeaeea?a i?ney iiiioa?ai?? iaea?eueo neeueieie aeieaoi?aie oeoieiai?
nae?aoe??, ui iae/ano?oa canoiniaothoueny a oaia??oi?e /an o e?eoaaii?
oa i?io?eaeoeoe? ?aoeeaeea?a ae?aceiai? oai?iae. Oaeiae iai a?aeiia
iaaaeeea e?euee?noue ?ia?o oe?a?inueeeo a/aieo, ui i?iaaaeeeeny ia
?a?iiaenueeiio (ca?aeii Iaano?eonueeith oaiaeith) ??ai? ae?aaiinoeee oa
eiio?ieth ca ?acoeueoaoaie e?eoaaiiy ii oae caai?e iaoiaeeoe?
“iiaea?eii?”, “iio??eii?” oa “/aoaa?oii?” oa?ai??, eio?? aeicaieeee a
oe?iei ?aeiiaiaeoaaoe aei ee?i?/ii? i?aeoeee o? /e ?io? ii?aeiaiiy
??cieo i?aia?ao?a [I.ss.Aaaae, A.Ae.Oaae??iei, 1997; N.I.Oea/, 1998].

Eeneioi?noue ai?noo oeoiea i?iaeiaaeothoue ?icaeyaeaoe ia eeoa ye iaeei
?c iniiaieo ao?iiaoiaaiaoe/ieo oaeoi??a aeieeiaiiy ae?aceiai? oai?iae,
aea ? ye oaeoi?, ca aeiiiiiaith aieeao ia yeee iiaeia aeinyaiooe
aee?eiaoaaiiy ae?aceiai? oai?iae iaa?oue i?e iiiioa?ai??
[?.?.Aeaaoy?ueiaa oa ni?aaao., 1994; ?.?.Aeaaoy?ueiaa oa ni?aaao., 1995;
?.?.I?eiea?aa oa ni?aaao., 1995].

Aaaaoi/eneaii? e?oa?aoo?i? aeaea?aea aeacothoue ? ia oa, ui canoinoaaiiy
eeoa ?ia?a?oi??a oeoieiai? nae?aoe?? i?ecaiaeeoue aei a?aaeeeaoe??
Helicobacter pylori o oai?eo ia ae?aceiao oai?iao [I.ss.Aaaae,
?.?.Aeaaoy?ueiaa, A.Ae.Oaae??iei, B.C.Aieiaaanueea, 1996; I.A.Oa?/aiei,
1996], ui o aaaaoueio aeine?aeiee?a aeeeeea? iaa?oioiaaiee noii?a
[A.A.?naeia, 1997; E.E.A?o?i oa ni?aaao., 1998; T.J.Borody at a1l,
1996]. A oie naiee /an aeai? na?oiai? e?oa?aoo?e i?i i?iaaaeaiiy
“iiaea?eii?”, “iio??eii?” oa?ai?? o oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee iieacothoue aaeeeee a?aenioie ia eeoa
oneeaaeiaiue a?ae iaaeeeaiaio?a, ui canoiniaoaaeeny, aea ? iaaaea/ a
a?aaeeeaoe?? Helicobacter pylori [I.Deltere at all, 1995; N.E.Ching at
all, 1996; W.A.De Boer at all, 1996; D.Y.Graham at all, 1996].

Iaoa ?iaioe. Oaeineiiaeaiiy oa?ai?? oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee oeyoii ii??aiyeueiiai aea/aiiy ae?aaiinoe/ieo
iiaeeeainoae “aeeoaeueiiai” oanoo, ee?i?/ii? aoaeoeaiino?
aioenae?aoi?ieo i?aia?ao?a c ??cieie iaoai?ciaie ae?? (naeaeoeaiee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-oie?iie?oee,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-a?noai?iiaeieaoi? oa ?ia?a?oi? i?ioiiiai? iiiie)
ye i?e iiiioa?ai??, oae ? a ii?aeiaii? c aioeaaeoa??aeueieie i?aia?aoaie
a eiiieaeniiio e?eoaaii? iaoneeaaeiaii? ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee.

Caaea/? aeine?aeaeaiiy. 1. Onoaiiaeoe i?noea “aeeoaeueiiai” oanoo a
ae?aaiinoeoe?, a?aaeeeaoe?? ? aee?eiaoaaiiy oai?eo ia iaoneeaaeiaio
ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee.

2. Aea/eoe aieea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-oie?iie?oeea — aano?ioeai?io;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-aeieaoi?o ?aoeaioi??a a?noai?io — ?ai?oeaeeio oa
aeieaoi?a i?ioiiiai? iiiie ae?oaiai iieie?iiy eiio?ieieo ia ee?i?/iee
ia?aa?a oai?iae, oaeaee?noue ?oaoethaaiiy ae?acie a oeeaoeei?
aeaaiaaeoeyoeiaei? eeoee, noai caaaeueiiai oa i?noeaaiai ?ioi?oaoo.

3. Aeyaeoe iiaeeeaino? cacia/aieo a?oi i?aia?ao?a noiniaii a?aaeeeaoe??
Helicobacter pylori i?e i?iaaaeaii? iiiioa?ai??.

4. Anoaiiaeoe /anoioo aeieeiaiiy ?aoeeaeea?a ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee i?ney e?eoaaiiy ??cieie a?oiaie aioenae?aoi?ieo
i?aia?ao?a i?e i?iaaaeaii? iiiioa?ai??.

5. Aea/eoe ae?aaiinoe/io oe?ii?noue “aeeoaeueiiai” oanoo ? ee?i?/io
aoaeoeai?noue aeayeeo iaaeeeaiaioicieo eiia?iaoe?e o oaeaeeino?
?oaoethaaiiy ae?aceiaeo aeaoaeo?a, a?aaeeeaoe?? Ielicobacter pylori,
a?aeiiaeaii? ?ioiiiai noaoono oa ciaioaiiy e?eueeino? ?aoeeaeea?a o
oai?eo ia iaoneeaaeiaio ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee.

Iaoeiaa iiaecia. Aia?oa ae?aaiinoeea ? eiio?ieue a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe?? i?iaiaeeeanue “aeeoaeueiei” oanoii o
ii??aiyii? c ?ioeie ae?aaiinoe/ieie oanoaie: CLO oanoii, ii?oieia?/iei
oa i?e?ia?ieia?/iei aea/aiiyi a?iioao?a. I?aeoaa?aeaeaii, ui
“aeeoaeueiee” oano ? “cieioei noaiaea?oii” o ae?aaiinoeoe? oa eiio?ieai
ca a?aaeeeaoe??th oae?eiaaeoa?ii? ?ioaeoe??. Aia?oa aea/aii aieea o?ueio
eean?a aioenae?aoi?ieo i?aia?ao?a (naeaeoeaiiai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-oie?iie?oeea,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-a?noai?iiaeieaoi?a oa ?ia?a?oi?a i?ioiiiai? iiiie)
ia a?aaeeeaoe?th Helicobacter pylori o oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee iaoiaeii “aeeoaeueiiai” oanoo. Anoaiiaeaii, ui
aeiaeai c i?aia?ao?a, yeee aea/aee, ia i?ecaiaeeoue aei a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe?? a aeiaeiiio c aeiaaee?a. Aia?oa a “iiaea?eiiio
ne?iiio” iaoiae? ianoaaeaiiy a aaaaoiiaoe?iiaeueieo, ioeueoeoeaio?e/ieo
aeine?aeaeaiiyo “iaioii?acie-eiio?ieie i?ioe ?ai?oeaeeio” aoea iieacaia
a?eueo aeniea ee?i?/ia aoaeoeai?noue aeieaoi??a i?ioiiiai? iiiie
ae?oaiai iieie?iiy o ii??aiyii? c aeieaoi?aie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-?aoeaioi??a a?noai?io.

Aia?oa c?iaeaii aeniiaie i?i oa, ui aeiaeai c o?ueio eean?a
aioenae?aoi?ieo i?aia?ao?a ia iiaea ? ia iiaeiai canoiniaoaaoenue o
aeaeyae? iiiioa?ai?? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee, ui
anioe?eiaaia c oae?eiaaeoa??icii. Aia?oa aeine?aeaeaiiy ii aea/aiith
a?aaeeeaoe?? i?iaaaeai? “cieioei aoaeiiii” — aeeoaeueiei oanoii, ui aea?
a??ia?aei?noue io?eiaieo ?acoeueoao?a 100%. E?eoaaiiy oai?eo ia
iaoneeaaeiaio ae?aceiao oai?iao, ui anioe?eiaaia c Helicobacter pylori,
iiaeiii i?iaiaeeoeny eeoa “iio??eiith” oa?ai??th c oaoa’yceiaei
aeeth/aiiyi eeneioiaeieoth/iai i?aia?aoo ae?oaiai iieie?iiy oa aeaio
aioeaaeoa??aeueieo i?aia?ao?a. Eiio?ieue a?aaeeeaoe?? oa aee?eiaoaaiiy o
aeaii? eaoaai??? oai?eo aeinoaoiuei i?iaanoe “aeeoaeueiei” oanoii.
Aia?oa a Oe?a?i? canoiniaaii aeey ae?aaiinoeee oae?eiaaeoa?ii? ?ioaeoe??
“aeeoaeueiee oano” ? iieacaii, ui a?i ? “cieioei noaiaea?oii” o
ae?aaiinoeoe? Helicobacter pylori oa ?? a?aaeeeaoe??.

I?aeoe/ia cia/aiiy. Aia?oa io?oe?eii a iaoiaee/ieo ?aeiiaiaeaoe?yo
I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie (1998 ?.) cai?iiiiiaaii
i?iaiaeeoe ae?aaiinoeeo oa e?eoaaiiy oai?eo ia ae?aceiao oai?iao ca?aeii
c ?a?iiaenueeei i?ioieieii (Iaano?eonueeee eiinainon), yeee ia?aaeaa/a?
i?e e?eoaaii? ae?aceiai? oai?iae ia eeoa ?oaoethaaiiy ae?aceiaiai
aeaoaeoo, aea ? oaoa’yceiay a?aaeeeaoe?th oae?eiaaeoa?ii? ?ioaeoe??.

Aia?oa i?aaenoaaeai? aeai? i?i iaaeioe?euei?noue e?eoaaiiy
iaoneeaaeiaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee anioe?eiaaii?
c Helicobacter pylori eeoa aeieaoi?aie eeneioii? i?iaeoeoe?? oeoieiaiai
ai?noo a iiiioa?ai??, aei yei? a a?oie aiie ia iaeaaeaee, aac
aioea?ioee?a, a?niooiaeo i?aia?ao?a, iao?ii?aeacieo oa ?ioeo, c iiaeyaeo
ia a?aenooi?noue ?o aeinoaoiuei? aoaeoeaiino? ii a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe??.

Aia?oa o a?aee?eoeo niinoa?aaeaiiy oa iiaea?eiei “ne?iei” iaoiaeii
iieacaia ia?aaaaa aeieaoi?a i?ioiiiai? iiiie ae?oaiai iieie?iiy —
eiio?ieieo iaae ?ioeie aeieaoi?aie oeoieiai? nae?aoe??: naeaeoeaiei
aeieaoi?ii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-oie?iie?oeeii — aano?ioeai?iii ? aeieaoi?ii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-?aoeaioi??a a?noai?io-?ai?oeaeeiii o oaeaeeino?
?oaoethaaiiy ae?aceiaeo aeaoaeo?a, cieeiaiiy ee?i?/ieo i?iya?a oai?iae.

Aia?oa a Oe?a?i? i?iaaaeaii ianoaaeaiiy ? e?eoaaiiy oai?eo o
a?aeiia?aeiino? c ?a?iiaenueeei i?ioieieii. Io?eiai? ?acoeueoaoe
aeicaieeee ?aeiiaiaeoaaoe ia?oei aoaiii a a?aaeeeaoe?? oae?eiaaeoa?ii?
?ioaeoe?? “iio??eio” oa?ai?th. “Iiaea?eia” oa?ai?y ia iiaeiia
canoiniaoaaoeny o e?eoaaii? oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee anioe?eiaaii? c Helicobacter pylori, oiio ui
aiia aea? aeoaea iecueeee (iaioa 50%) a?aenioie a?aaeeeaoe??
Helicobacter pylori.

?aeiiaiaeiaaii, ii iiaeeeaino?, i?iaiaeeoe i?aea?? aioeaaeoa??aeueieo
iaaeeeaiaio?a noai?i ?iaeea?aeoaeueii, ia iniia? i?e?ia?ieia?/ieo
aeaieo, /a?ac ??cio /ooeea?noue oai?eo aei aioei?e?iaieo i?aia?ao?a.

Io?eiai? i?e ii??aiyeueieo aeine?aeaeaiiyo aeai? aeicaieeee
?aeiiaiaeoaaoe a i?aeoeeo oa?aiaao?a caaaeueii? i?aeoeee oa
aano?iaioa?ieia?a iaea?eueo aoaeoeai? ii?aeiaiiy aioenae?aoi?ieo oa
i?ioei?e?iaieo i?aia?ao?a ??cieo eean?a o e?eoaaii? ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee.

Ooai?aia nenoaia ii ianoaaeaiith oae?eiaaeoa?ii? ?ioaeoe?? o oai?eo ia
ae?aceiao oa iaae?aceiao aeeniain?th a i?no? Ee?a? c canoinoaaiiyi
“aeeoaeueiiai” oanoo oa anoaiiaeaiiyi aioea?ioeei?acenoaioieo
oe?a?inueeeo ooai?a Helicobacter pylori.

Iieiaeaiiy, ui aeiinyoueny ia caoeno.

1. O?aaciee “aeeoaeueiee” oano ? no/aniei, aeniei?ioi?iaoeaiei, c?o/iei
oa aacia/iei caniaii ae?aaiinoeee ye iayaiino?, oae ? a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe?? o oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee.

2. An? i?ioeeeneioi? i?aia?aoe, ui i?aeeyaaee aea/aiith a iiiioa?ai??,
i?enei?ththoue ?oaoethaaiiy ae?acie a aeaaiaaeoeyoeiae?e eeooe?,
anioe?eiaaieo c Helicobacter pylori. Iaea?eueo aoaeoeaieie e?ea?nueeeie
caniaaie c oe??? a?oie ? ?ia?a?oi?e i?ioiiiai? iiiie ae?oaiai iieie?iiy.
Aea eo?niaa e?eoaaiiy eeoa i?ioeeeneioieie i?aia?aoaie ia iiia?aaeaea?
aeieeiaiiy ?aoeeaeea?a oai?iae.

3. Ni?eyth/e oaeaeeiio ?oaoethaaiith ae?aceiaeo aeaoaeo?a a oeeaoeei?
aeaaiaaeoeyoeiaei? eeoee, i?ioeeeneioi? i?aia?aoe cieaeothoue ai?no
Helicobacter pylori a oeoieo, aea, yeui ?o canoiniaoaaoe a iiiioa?ai??,
aiie eeoa cieaeothoue ian?iai?iiy aeoiaeaiaeueii? ciie Helicobacter
pylori, ia i?ecaiaey/e aei a?aaeeeaoe?? Helicobacter pylori. Oaeiae ia
a?aeiiaeththoueny iieacieee caaaeueiiai oa i?noeaaiai ?ioi?oaoo.

4. Io?eiai? a?aeiiino? i?i a?aenooi?noue a?aaeeeaoe?? i?ney iiiioa?ai??
i?ioeeeneioieie i?aia?aoaie c ??ciei iaoai?ciii ae?? noaaeyoue ieoaiiy
i?i ci?ie e?eoaaiiy oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee
canoinoaaiiyi o?eueee i?ioeeeneioieo i?aia?ao?a.

5. Canoinoaaiiy iiaea?eii? oa?ai?? o e?eoaaii? oai?eo ia ae?aceiao
oai?iao aeaaiaaeoeyoeiaei? eeoee iaaeioe?eueii o ca’yceo c iecueeei
a?aenioeii a?aaeeeaoe?? Helicobacter pylori. sse aacenia e?eoaaiiy
iiaeiia canoiniaoaaoenue “iio??eia” oa?ai?y, ui neeaaea?oueny c iaeiiai
eeneioicieaeoth/iai i?aia?aoo, aaaeaii ?ia?a?oi?a i?ioiiiai? iiiie
ae?oaiai iieie?iiy, ? aeaio aioeaaeoa??aeueieo i?aia?ao?a.

6. I?aea?? i?ioei?e?iaieo i?aia?ao?a aeey i?iaaaeaiiy “iio??eii?”
oa?ai?? iiaeiai i?iaiaeeoeny ?iaeea?aeoaeueii ia iniia? aeaieo i?i
/ooeea?noue Helicobacter pylori aei aioeaaeoa??aeueieo cania?a.
Eiio?ieue ca a?aaeeeaoe??th oae?eiaaeoa?ii? ?ioaeoe?? iiaeiai
i?iaiaeeoeny o?aaciei “aeeoaeueiei oanoii”.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Io?eiai? a ?iaio? aeai?
canoiniaothoueny o iaa/aeueiiio i?ioean? ia eaoaae?? oaeoeueoaonueei? oa
aini?oaeueii? oa?ai?? ? 1 ? ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo,
eaoaae?ao oaeoeueoaonueei? oa aini?oaeueii? oa?ai?? E?einueeiai,
A?iieoeueeiai iaaee/ieo oi?aa?neoao?a, eaoaae?ao oa?ai?? oa
aano?iaioa?ieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe.
Oaeiae i?aeoe/i? ?acoeueoaoe ?iaioe canoiniaothoueny a
caaaeueiioa?aiaaoe/ieo oa aano?iaioa?ieia?/ieo a?aeae?eaiiyo i. Ee?aa ?
Oe?a?ie.

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?? aeieeaaeaeeny ia 11
Anana?oiueiio eiia?an? aano?iaioa?ieia?a (i.A?aeaiue, 1998), 14
Oe?a?inueeiio c’?cae? oa?aiaao?a (i.Ee?a, 1998), 4-io ?in?enueeiio
aano?iaioa?ieia?/iiio oeaei? (i.Iineaa, 1998).

Ioae?eaoe?? ca oaiith aeena?oaoe??. Ii oai? eaiaeeaeaonueei?
aeena?oaoe?? iioae?eiaaii 2 iiiia?ao?? oa 5 iaoeiaeo ?ia?o.

Aeaeea?aoe?y ?iaeea?aeoaeueiiai aianeo aeena?oaioa. Iniaeeaee aianie
aeena?oaioa o aeeiiaiiy aeena?oaoe?eii? ?iaioe iieyaa? a oiio, ui a?i
naiino?eii c?iaea iaeyae no/anii? e?oa?aoo?e, aecia/ea iaoo oa caaea/?
?iaioe, naiino?eii i?ia?a ee?i?/i?, eaai?aoi?i? oa ?ino?oiaioaeuei?
ianoaaeaiiy, i?ia?a aiae?c io?eiaieo aeaieo oa ?o noaoenoe/io ia?iaeo.

No?oeoo?a oa ci?no. Aeena?oaoe?y neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, aeaa oa iaoa??aee oa iaoiaee aeanieo aeine?aeaeaiue,
iaaiai?aiiy io?eiaieo aeaieo, aeniiae?a. Nienie e?oa?aoo?e neeaaea?oueny
c 400 aeaea?ae. Aeena?oaoe?y aeeeaaeaia ia 160 noi??ieao iaoeiiieno.
?ethno?iaaia 11 noaiaie oa 40 oaaeeoeyie.

INIIAIEE CI?NO AeINE?AeAEAIUe

Iaoa??aee oa iaoiaee

Ee?i?/ia oa?aeoa?enoeea oai?eo. Aoei ianoaaeaii oa i?ie?eiaaii 328
oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee o oac? caaino?aiiy
aai aia?oa aeyaeaiith. Ianoaaeaiiy, e?eoaaiiy oa iiaeaeueoa
niinoa?aaeaiiy oai?eo i?iaiaeeeeny a ee?i?eao eaoaae? oaeoeueoaonueei?
oa?ai?? ? 1 oa ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo oa
Oe?a?ii-i?iaoeueeiai i?ioeae?aceiaiai aano?iaioa?ieia?/iiai oeaio?o.

A aeine?aeaeaiiy aeeth/ai? eeoa iaoe??ioe c iayai?noth Helicobacter
pylori, o a?oe? a?ae 18 aei 75 ?ie?a c aiaeineii?/ii i?aeoaa?aeaeaiith
iaoneeaaeiaiith ae?aceith aeaaiaaeoeyoeiaei? eeoee. O an?o ianoaaeaieo
ae?aceia? aeaoaeoe aoee ie?oaei? aai iaaeueii? oi?ie, c iaa?yeeeie,
i?aeiyoeie e?ayie, aeii ae?acee iie?eoi a?eei iaeueioii aai aeiaoi-a?eei
iaeueioii o?a?eio. Oai??, o yeeo niinoa??aaeanue noaae?y ?oaoethaaiiy
ae?acee, a ianoaaeaiiy ia aeeth/aeenue. I?i?iaeuei? ?ici??e ae?aceiaiai
aeaoaeoo neeaaeaee 5 ii, iaeneiaeuei? 20 ii aai ieiuath a?ae 0,5 ni2 aei
2 ni2.

C 328 ianoaaeaieo o 53 (16,1%) ae?aceiaa oai?iaa aoea aeyaeaia aia?oa.
?aooa iaoe??io?a (275) no?aaeaeaea ia ae?aceiao oai?iao ??ciiai nooiaiy
aaaeeino?.

An? oai?? aoee ?iciiae?eai? ia 5 a?oi a?aeiia?aeii aei iinoaaeaieo
caaea/. A ia?o?e a?oi? aoei 45 oai?eo ? an? aiie io?eioaaee aano?ioeai?i
a aeic? 50 ia o?e/? ia aeaiue oa ia i?/. Ianoaaeaiiy i?iaiaeeeeny o
a?aee?eoeo niinoa?aaeaiiyo. Ae?oao a?oio neeaa 91 oai?ee, ui io?eioaaee
?ai?oeaeei, ? o?aoth a?oio neeaee 92 iaoe??ioe, ye? io?eioaaee
eiio?ieie. Ianoaaeaiiy i?ae ae?oaith oa o?aoueith a?oiith aoee
i?iaaaeai? “iiaea?eiei” ne?iei iaoiaeii, yeee i?eioneaa iaciaiiy i?
e?ea?ai, i? oai?ei, ui io?eio? iaoe??io o i?ioean? e?eoaaiiy. Eiio?ieie
i?ecia/aee a aeic? 40 ia uiaeaiii, iaeei ?ac ia aeaiue ca ni?aeaieii.
?ai?oeaeei — iaeei ?ac ia aeaiue aaa/a?? o aeic? 300 ia ia?aae niii.
Oaaeaoee eiio?ieieo, ?ai?oeaeeio oa ieaoeaai aoee c?iaeai? oa oiaeiaai?
cian?i iaeiaeiai, ui aeeeth/aei iiaeeeaino? ?o aecia/aiiy a?coaeueii.
An? aeai? ianoaaeaiiy eaai?aoi?ieo, a?io?i?/ieo, aiaeineii?/ieo oa ?ioeo
ianoaaeaiue caiineeenue a niaoe?aeuei? i?ioieiee oa a?aei?aaeyeeny a i.
Eiinoaioe O?I, aea ia?iaeyeeny. Iio?i a ?icoeo?iaaiiio aeaeyae? ie ?o
io?eioaaee, aiae?coaaee oa aeei?enoiaoaaee o ?iaio?. *aoaa?oo oa i’yoo
a?oio neeaee oai??, yeei i?iaiaeeeinue e?eoaaiiy ??cieie oa?aiaaoe/ieie
eiiieaenaie a aeaio eiia?iaoe?yo. *aoaa?oa a?oia: eiio?ieie ii 40 ia 1
?ac ia aeaiue ?aieii ca ni?aeaieii, aiieneoeee?i ii 500 ia 4 ?ace ia
aiue i?ae /an ?ae? ? ia i?/. Iaeaeaa ia?aia?aoe i?eeiaee i?ioyaii aeaio
oeaei?a. I’yoa a?oia: eiio?ieie ii 40 ia ? ?ac ia aeaiue a?aioe? ca
ni?aeaieii, aiieneoeee?i ii 500 ia 4 ?ace ia aeaiue, iao?ii?aeacie ii
500 ia 3 ?ace ia aeaiue i?ae /an ?ae?. E?eoaaiiy i?ioyaii aeaio oeaei?a.
Oai?? an?o 5 a?oi ianoaaeoaaeenue aei e?eoaaiiy, /a?ac 2 ? 4 oeaei?
e?eoaaiiy oa /a?ac 4-5 oeaei?a i?ney cae?i/aiiy e?eoaaiiy (eiio?ieuei?
ianoaaeaiiy ia a?aaeeeaoe?th Ielicobacter pylori).

An? oai?? ciaoiaeeeeny i?ae niinoa?aaeaiiyi i?ioyaii 18 i?nyoe?a.
Aeoeaia ianoaaeaiiy i?iaiaeeeiny /a?ac 3, 6, 9, 12, 15 oa 18 i?nyoe?a, a
oaeiae i?e eiaeiiio iiaiio ?aoeeaeea?.

Iaoiaee ianoaaeaiiy. Ae?aaiic ae?aceiai? oai?iae aeaaiaaeoeyoeiaei?
eeoee noaaeany ia i?aenoaa? eiiieaeniiai ee?i?/iiai, aiaeineii?/iiai,
?ino?oiaioaeueiiai, i?e?ia?ieia?/iiai ianoaaeaiiy, iniaeeao oaaao
i?eae?eyee aiaiiaco.

An?i oai?ei, e??i caaaeueiii?eeiyoeo ee?i?ei-eaai?aoi?ieo ianoaaeaiue,
i?iaiaeeeeny a?io?i?/i? ianoaaeaiiy e?ia?: caaaeueiee a?eie oa a?eeia?
o?aeoe??, caaaeueiee a?e??oa?i oa eiai o?aeoe??, ia/?ieia? i?iae, oeoei?
e?ia?, aeaeo?ie?oe (eae?e, eaeueoe?e, iao??e, oei?), oieanoa?ei oa
aaoa-e?iii?ioa?aee, eae ia i?eoiaaio e?ia.

An?i oai?ei, yeeo a?ae?a?aee aeey ianoaaeaiiy, i?ney ee?i?/iiai
ianoaaeaiiy i?iaiaeeany “aeeoaeueiee” oano, o?a?iacioaaiaano?ineii?y c
a?iin??th oa iiaeaeueoei ii?oieia?/iei aeine?aeaeaiiyi oaeaeeei CLO
oanoii.

“Aeeoaeueiee oano” c na/iaeiith iaeaaeeoue aei iiaeo ia?iaaceaieo
iaoiae?a ae?aaiinoeee oae?eiaaeoa?ii? ?ioaeoe??. Ia? 100% /ooeea?noue oa
niaoeeo?/i?noue, cian?i iaoe?aeeeaee oa aacia/iee. I?eioeei iaoiaeo
i?aaenoaaeaii ia iaethieo 1. A?i iniiaaiee ia oiio, ui i?ney
ia?i?aeueiiai i?eeiio ?ic/eio na/iaeie a aiaeueneiiaiio nieo, i?/aii?
ia?aae?iaeoeaiei
picscalex100010009000003910000000200170000000000050000000902000000000400
000002010100050000000102ffffff00040000002e011800050000003102010000000500
00000b0200000000050000000c02e00140011200000026060f001a00ffffffff00001000
0000f6ffffffb4ffffff36010000940100000b00000026060f000c004d61746854797065
0000200017000000fb0220ff0000000000009001000000cc0002001054696d6573204e65
7720526f6d616e2043797200ccdd040000002d0100000a000000320af400310002000000
3133700070000a00000026060f000a00ffffffff01000000000010000000fb0210000700
00000000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001
000003000000000000f000000000N, o?aaca Helicobacter pylori iaoaaie?co?
i?/aio na/iaeio ? aea?eueiy? i?/aiee aoaeaeeneee aac, yeee aecia/a?oueny
o iia?o??, ui aeaeeoa?oueny /a?ac 30 oaeeei.

A iaoeo aeine?aeaeaiiyo aeey i?iaaaeaiiy aeeoaeueiiai oanoo aoa
aeei?enoaiee ?io?a/a?aiiee ?cioiiiee aiae?caoi? i?iaoeueei? o??ie Wagner
Analysen Technik Vertrebs nenoaie IRIS.

Eeneioiooai?thth/a ooieoe?y oeoiea aecia/aeanue ?I-iao?e/iei iaoiaeii o
an?o oai?eo.

I?eoe?eueia a?iin?y i?iaiaeeeany c 5-7 i?noeue aio?oio, acaeiaae aaeeei?
e?eaecie, ii ia?aaei?e no?ioe? aio?oio, ia 2 ni a?ae
i?ei?i-aeoiaeaiaeueiiai ia?aoiaeo, ?c ciie caiaeaiiy a oeeaoeei?
aeaaiaaeoeyoeiaei? eeoee, ui ioi/o? ae?aceiaee aeaoaeo.

Oaeaeeee o?aaciee aai CLO oano i?iaiaeeany an?i oai?ei.
Aeei?enoiaoaaeeny oae? oano-nenoaie ye Delta West Ltd, Bently, Australia
? Denol oano (Yamanochi).

An?i oai?ei 4 oa 5 a?oi i?iaiaeeee i?e?ia?ieia?/ia aeine?aeaeaiiy, aeey
/iai a?aee a?iioaoe c 4 ae?eyiie, ye? iienai? aeua, aiiiaai?coaaee ?o ca
aeiiiiiaith iaoai?/iiai aeac?ioaa?aoi?a ? aeei?enoiaoaaee aeey iin?ao ia
oieieaaeiee aaa?, yeee aiooaaany ia iniia? a?eo?ao-aaa?o c aeiaeaoeii
10% aeiii?nueei? ethaenueei? e?ia? c naeaeoeaieie aeiaaaeaie
(aioioa?eoeei A-2 iea-e, iae?aeeeniaa eeneioa — 40 iea-ie, aaieii?oeei —
10 iea-ie. Iin?ae ?ieoaoaaee i?ioyaii 5-7-4 ae?a i?e oaiia?aoo?? 37 iN a
iae?iaa?io?eueieo oiiaao) a aiaa?inoao? c aeei?enoaiiyi noi?o? o?i?/ieo
i?aia?ao?a, ui i?noyoue aoiinoa?o c 5% eiioeaio?aoe??th eenith oa 10%
eiioeaio?aoe??th aoaeaeeneiai aaco.

Aei aeaeo Helicobacter pylori a?aeiineee a?aiiaaaoeai? ni??aeaiiae?ai?
aaeoa???, ye? aeaaaee ??no ia iienaiiio na?aaeiaeu? i?ney 5-7 ae?a
eoeueoeaoaaiiy o aeaeyae? iai?ai?ici?eo ae??aieo (ae?aiao?ii 0,5-? ii)
n??oaaoeo eieii?e, ui neioacoaaee o?aaco, eaoaeaco oa ieneaeaco, no?eeeo
aei 40 iea-ie iae?aeeeniai? eeneioe.

An? io?eiai? ?acoeueoaoe aeine?aeaeaiiy aoee ia?iaeai? iaoiaeii
aa??aoe?eii? noaoenoeee. Aecia/aee I-na?aaeiueia?eoiaoe/io,
-na?aaeiueieaaae?aoe/ia a?aeoeeaiiy, m-na?aaeith iiieeeo
na?aaeiueia?eoiaoe/ii?, t-e?eoa??e No’thaeaioa oa ?-??aaiue
a??ia?aeiino?. Oaeiae a ie?aieo aeiaaeeao aeey noaoenoe/ii? ia?iaee
iaoa??aeo aoa canoiniaaiee iaia?aiao?e/iee iaoiae
A?eueeieniia-Iaiia-O?oi?[A.A. Aaieei, A.A. Aoaea?, 1973].

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe

OA ?O IAAIAI?AIIss

Ia ia?oiio aoai? iaie aoei i?iaaaeaii aea/aiiy “aeeoaeueiiai” oanoo a
ae?aaiinoeoe? caoai?thaaiue, ye? anioe?eiaai? c oae?eiaaeoa?iith
?ioaeoe??th oa ?? a?aaeeeaoe??th. Aeey oeueiai o an?o 328 ianoaaeaiiyo
i?iaiaeeeinue aecia/aiiy Helicobacter pylori e?eueeiia iaoiaeaie:
a?noieia?/iei, oaeaeeei CLO oanoii, “aeeoaeueiei” oa a eoeueoo??
oeaieie. I?iaaaeaia ii??aiyiiy io?eiaieo aeaieo iieacaei, ui
“aeeoaeueiee” oano aoa iiceoeaiei o an?o 100% ianoaaeaieo aei e?eoaaiiy
oai?eo, oaeiae 100% iiceoeaiei aoa ? CLO oano, ui noino?oueny
a?noieia?/iiai iaoiaeo, oi a?i aoa iiceoeaiei o 298 (90,24%) oai?eo, a
i?e?ia?ieia?/iiai — o 283 (86,28%). Oaeei /eiii “aeeoaeueiee” oano
iiaeiai aooe iaee?auei i?e i?iaaaeai? ye ae?aaiinoeee, oae ?, iniaeeai,
a?aaeeeaoe?? oae?eiaaeoa?ii? ?ioaeoe??, oiio ui i?e eiai i?iaaaeaii?
aeeeth/aii ?a?io?eoaaiiy oai?iai.

Iio?i aoei i?iaaaeaii ii??aiyeueia aea/aiiy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-oie?iie?oeea (aano?ioeai?io),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-aeieaoi?a ?aoeaioi??a a?noai?io (?ai?oeaeeio) oa
aeieaoi??a i?ioiiiai? iiiie (eiio?ieiea) ia ee?i?/iee ia?aa?a
iaoneeaaeiaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee, eeneioio
i?iaeoeoe?th oeoiea, noai caaaeueiiai oa i?noeaaiai ?ioi?oaoo oa
oaeaee?noue ?oaoethaaiiy ae?acee oa a?aaeeeaoe?? Helicobacter pylori a
iiiioa?ai??.

Anueiai a oe?e na??? niinoa?aaeaiue aoei ianoaaeaii 228 oai?eo ia
ae?aceo aeaaiaaeoeyoeiaei? eeoee a o?ueio a?oiao. O oai?eo an?o o?ueio
a?oi, ui ianoaaeoaaeenue aei e?eoaaiiy, iaa i?noea a?eue a 100%
aeiaaee?a, i?e/iio, nooi?iue ae?aaeaiino? aoea eeoa aeaio aeae?a:
iii??ia oa aaaeea. Ui noino?oueny ?ioeo neiioii?a ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee, ui iaea?eueo /anoi aoaathoue, oi, aiie
?nioaaee ??aeoa a?ae aieth. Eeneo ?aao?a?oaoe?th a?aei?/aee o 163 oai?eo
— 71,49% a?ae an??? e?eueeino? ianoaaeaieo, ia/?th — o 179 (79,5%),
ioaeioo — 116 ( 50,87%) oa aethaioo o 78 (43,21%), i?e/iio nooi?iue
ae?aaeaiino? aeacaieo neiioii?a aoea a?eueoith i??ith iii??ia oa eaaea.

Aeine?aeaeaiiy nae?aoe?? oeoieiaiai nieo ?I-iao?ii aei e?eoaaiiy
iieacaei, ui o 211 oai?eo (92,57%) aoea i?aeaeuaia eeneioiooai?thth/a
ooieoe?y oeoiea, o 14 (7,43%) — ii?iaeueia.

O oai?eo ia ae?aceiao oai?iao o an?o o?ueio a?oiao niinoa??aaeinue
a??ia?aeia cieaeaiiy A-?icaoeiooai?thth/eo ee?oei o ii??aiyii? c
eiio?ieueiith a?oiith (caei?ia? ethaee) ? neeaee a?aeiia?aeii a eiio?ie?
53,2+4,9; a ia?o?e a?oi? 32,6+2,9 (?<0,01); ae?oa?e 34,1+3,16 (?<0,01); o?ao?e 33,9+4,8 (?<0,01). Ai?no AAN-?IE a??ia?aeii ia a?ae??ciyany o oai?eo a?ae caei?iaeo. Noiniaii a?aenioeiaiai ? aaniethoiiai /enea ioeueiaeo e?ioioeeo?a, oi ?o ca?eueoaiiy o ii??aiyii? c eiio?ieueiith a?oiith aoei a??ia?aeiei a on?o o?ueio a?oiao ? neeaaeaei a?aeiia?aeii a eiio?ie? ? ii a?oiao: 18,8+1,5 (p<0,01); 42,1+2,1 (?<0,01); 39,6 +3,41 (p<0,01); 39,6 + 4,1 (p<0,01). A??ia?aeii? ??cieoe? i?ae aea/aieie ?ioiieia?/ieie iieacieeaie o oai?eo an?o o?ueio a?oi ia aoei. O oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee a aeoeaio oaco aei e?eoaaiiy niinoa??aaeinue a??ia?aeia cieaeaiiy an?o iniiaieo noaiiioeyoe?e e?ioioeeo?a e?ia?, ui aeaco? ia cieaeaiiy O-ee?oeiiiai eaioethaa ?ioi?oaoo o oai?eo an?o o?ueio a?oi, ui aea/aee. Iaiao?aeii i?aee?aneeoe, ui nooi?iue cieaeaiiy a on?o o?ueio a?oiao aoea i?eaeecii iaeiaeiaa ? a??ia?aeii ia a?ae??ciyeanue o oai?eo i?ae a?oiaie, ui ianoaaeoaaeenue. E?euee?nia cieaeaiiy O-e?ioioeeo?a noi?iaiaeaeo?oueny ? a??ia?aeiei ??ceei cieaeaiiyi ?o ooieoe?iiaeueii? aeoeaiino? a ?aaeoe?? AOE c OAA ? neeaaea? a?aeiia?aeii a eiio?ie? a aeine?aeieo a?oiao 81,3+7,11; 45,3+3,99; 44,8+4,06; 46,7+2,91 (?< 0,01 aeey an?o o?ueio a?oi). Noiniaii ooieoe?iiaeueii? aeoeaiino? A-nenoaie ?ioi?oaoo, oi ooo eeoa aeey ?ioiiaeiaoe?io A a?aei?/aii a??ia?aeia cieaeaiiy a?ae 2,5+0,19 a eiio?ieuei?e a?oi?, aei 1,65+0,19; 1,65+0,2; 1,56+0,17 a o?ueio aeine?aeieo a?oiao i?e ?<0,01 i?ae eiio?ieai oa aeine?aeiith a?oiaie. Ai?no ?ioiiaeiaoe?i?a I oa G a??ia?aeii ia a?ae??ciyeeny a?ae eiio?ieueii? a?oie, iacaaaeath/e ia oa, ui o an?o o?ueio a?oiao aeyaeeanue oaiaeaioe?y aei ca?eueoaiiy lg I , aea a aeiaei?e a?oi? ia aoei a??ia?aeii? a?aei?ie a?ae eiio?ieueii? a?oie. Oaeiae o an?o a?oiao oai?eo ia ae?aceiao oai?iao a?aei?/aii cieaeaiiy oaaioeeoa?ii? aeoeaiino?, yea neeaaea? a eiio?ieuei?e a?oi? 89,3+7,6 ? aeine?aeieo a?oiao 43,6+3,9; 45,5+4,11; 42,8+3,99 i?e ?<0,01. A?aenioie ee?oei, ye? niiioaiii a?aeiiaeththoue i?o?inei?e oao?acie?e a ca?ia oa?iacaio, i?aeaeuaiee aei 65,3+4,21 a ia?o?e a?oi?; 6,09+3,7 a ae?oa?e ? 63,9+4,8 a o?ao?e; a eiio?ie? 45,3+3,7 i?e ?<0,01. Oae? ci?ie oa?aeoa?i? aeey iacaaa?oaiiai oaaioeeoico oa i?eai?/aiiy oaeoi??a ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio. Io?eiai? aeai? i?i noai ?ioi?oaoo o oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee a noaae?? caaino?aiiy iieacaee iayai?noue ?ioiieia?/ii? iaaeinoaoiino?, iaeiaeiai ae?aaeaiee o an?o o?ueio a?oiao oai?eo aei e?eoaaiiy. Ai?no nae?aoi?iiai lg A a oeoieiaiio nieo oa neei? o oai?eo a??ia?aeii cieaeaiee ? ?nio? iaeiaeiaa oaiaeaioe?y aei cieaeaiiy nae?aoi?iiai lg A o an?o na?aaeiaeuao (oeoieiaee n?e, neeia, ia?eoa?e/ia e?ia). O an?o oai?eo aei e?eoaaiiy aoa i?iaaaeaiee “aeeoaeueiee” oano, yeee aoa iiceoeaiee. *a?ac 2 oeaei? an? oai?? aoee ianoaaeai? ca?aeii ieaio. I?aeoe/ii o an?o oai?eo ee?i?/i? neiioiie ia eeoa ciaioeeenue, a cieeee, aeiyoie neeaea iaaaeeea a?oia oai?eo c iii??iei oa ??cei ae?aaeaiei aieueiaei neiae?iiii a 1 oa 2 a?oiao. Oaea ae oaiaeaioe?y a?aei?/aia a oe?o aea a?oiao a?aeiinii a?ae?eaeee, ia/??, ioaeioe ? aethaioe. A?aenooi?noue ee?i?/ieo neiioii?a ae?aceiai? oai?iae /a?ac aeaa oeaei? iiiioa?ai?? aoea eeoa a o?ao?e a?oi?, aea canoiniaoaaany aeieaoi? i?ioiiiai? iiiie ae?oaiai iieie?iiy - eiio?ieie. *a?ac /ioe?e oeaei? i?ney ii/aoeo e?eoaaiiy o?eueee o 4-o oai?eo 1 a?oie, ui i?eeiaee aano?ioeai?i, caeeoaeenue iacia/ii ae?aaeai? aieueia? oa aeeniaine/i? ii?ooaiiy. Oai?? ae 2 oa 3 a?oi ia iaee i?yeeo nea?a. *a?ac 2 oeaei? e?eoaaiiy a on?o 3 a?oiao iaee i?noea caai?iiy ae?aceiaiai aeaoaeoo a?eueo, i?ae ia 50% niinoa?aaeaiue. Aea, yeui o oai?eo 1 a?oie, ui e?eoaaeeny aano?ioeai?iii, oey oeeo?a ??aiyeanue 51,16%, oi aeey oai?eo ae?oai? a?oie, ye? e?eoaaeeny ?ai?oeaeeiii, oea 75,56%, a aeey oai?eo 3 a?oie, ui e?eoaaeeny eiio?ieieii, oea aaea 90% ae?acie, ui caai?eeny. *a?ac 4 oeaei? e?eoaaiiy a?aenioie ?oaoethaaiiy ae?aceiaeo aeaoaeo?a neeaa 81,40%, 95,56%, 98,89% a?aeiia?aeii a 1, 2 oa 3 a?oiao. Ci?iai? iieacieee oeaieiiiai oa aoii?aeueiiai ?ioi?oaoo i?ney e?eoaaiiy a??ia?aeii ia iiiiaethaaeeny, oiaoi o oai?eo, o yeeo aoea ?ioiieia?/ia iaaeinoaoi?noue, aiia caeeoeeanue ? i?ney i?iaaaeaiiai e?eoaaiiy. Ai?no nae?aoi?iiai lg A, yeee aoa a??ia?aeii cieaeaiee a ?iciae oai?iae, oae ? caeeoeany aac a??ia?aeieo ci?i /a?ac 4 oeaei? i?ney iiiioa?ai??. I?iaaaeaiee eiio?ieueiee “aeeoaeueiee” oano /a?ac 4 -5 oeaei?a i?ney cae?i/aiiy e?eoaaiiy aeyaeany iiceoeaiei o an?o 100% oai?eo, iacaaaeath/e ia a?aenooi?noue o ieo aoaeue-yeeo ee?i?/ieo i?iya?a oai?iae. Oaeei /eiii, i?iaaaeai? ianoaaeaiiy iieacaee, ui canoinoaaiiy iiiioa?ai?? iaea?eueo a?aeiieie ? neeueiiae?th/eie i?ioeeeneioieie i?aia?aoaie - Ipicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c020002c0001200000026060f001a00ffffffff0000100 00000f6ffffffc0ffffffb6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00131000100000 0310070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000ffffff-oie?iie?oeeaie, Ipicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c02000200011200000026060f001a00ffffffff0000100 00000f6ffffffc0fffffff6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00140000100000 0320070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000000000-aeieaoi?aie ?aoeaioi??a a?noai?io ? aeieaoi?aie i?ioiiiai? iiiie i?e iiceoeai?e ae?? ia ee?i?/io aeeiaieeo oai?iae i?ecaiaeeoue aei ?oaoethaaiiy ae?aceiaiai aeaoaeoo, ia i?ecaiaeeoue aei a?aaeeeaoe?? Ielicobacter pylori oa ii?iae?caoe?? aea/aieo ?ioiieo iieaciee?a o oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee. Oea noino?oueny ia eeoa noaio caaaeueiiai ?ioi?oaoo, aea ? i?noeaaiai ?ioi?oaoo. I?ney oiai, ye aoei anoaiiaeaii, ui o oai?eo an?o 3 a?oi, o yeeo a ?acoeueoao? e?eoaaiiy ianooieei ?oaoethaaiiy ae?aceiaiai aeaoaeoo, a?aei?/aany iiceoeaiee “aeeoaeueiee” oano, iaie aoea iinoaaeaia caaea/a i?ine?aeeoaaoe i?ioyaii ?ieo e?euee?noue oa a?aenioie ?aoeeaeea?a o iaoe??io?a. C oe??th iaoith an?o oai?eo i?ney 3, 6, 9, 12 i?nyoe?a cai?iooaaee ia ianoaaeaiiy. Oaeei /eiii, aoei anoaiiaeaii, ui canoinoaaiiy a iiiioa?ai?? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee eeneioicieaeoth/eo i?aia?ao?a ??cieo a?oi oaeaeei onoaa? ee?i?/i? i?iyae oai?iae, i?enei?th? ?oaoethaaiiy ae?aceiaiai aeaoaeoo, aea ia ni?e/eiy? a?aaeeeaoe?? Helicobacter pylori ? ia cieaeo? /anoioo ?aoeeaeoaaiiy ae?aceiai? oai?iae i?ioyaii iaeaeeae/iai ?ieo. Ianooiiei aoaiii aoei aea/aiiy ii??aiyeueii? aoaeoeaiino? aeaio eiia?iaoe?e i?ioeae?aceiaiai e?eoaaiiy a ?oaoethaaii? ae?acie, a?aaeeeaoe?? Helicobacter pylori ? iiiiaeaii? ?ioiieia?/ii? iaaeinoaoiino? o oai?eo ia iaoneeaaeiaio ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee. Iacaeaaeii a?ae e?eoaaiiy, ui io?eioaaee oai?? a ia?oeo 3 a?oiao, an? oai??, o yeeo aeieeee caaino?aiiy i?ioyaii 6 i?nyoe?a (43 oai?eo) ? aeiaaaeai? aei ieo 57 oai?eo, o yeeo aoea ae?aaiinoiaaia ae?aceiaa oai?iaa aeaaiaaeoeyoeiaei? eeoee i?e OAAeN, aoa iiceoeaiee “aeeoaeueiee” oano, aoee ianoaaeai? aei e?eoaaiiy, ca?aeii c? noaiith i?ioieieo. Oaea iciaea ae?aceiai? oai?iae ye a?eue, niinoa??aaeanue o an?o 100% oai?eo. Ae?aaeai?noue oeueiai neiioiio aoea ??cia, aea a?i aoa i?enooi?e caaaeaee o oai?eo aei e?eoaaiiy. Ae?aaeaii?noue ?ioeo neiioii?a aoea iaio ae?aaeaia. Eenea ?aao?a?oaoe?y iaea i?noea o 60% oai?eo 4 a?oie ? o 62% oai?eo 5 a?oie, ia/?y o 40% 4 a?oie ? o 48% 5 a?oie, ioaeioa - a?aeiia?aeii o 12% ? 18%, aethaioa -a?aeiia?aeii o 6 ? 8%. An?i oai?ei aei e?eoaaiiy aoee aecia/ai? ? i?iaiae?ciaai? aeaye? ?ioiieia?/i? iieacieee, cie?aia, noai ianiaoeeo?/ieo oaeoi??a caoenoo oa ai?no nae?aoi?iiai lg A a neei?. Iieacieee oaaioeeoa?ii? oa iaoaaie?/ii? aeoeaiino? iie?ii?oieo eaeeioeeo?a o oai?eo aei e?eoaaiiy aoee a??ia?aeii cieaeai?. Oea noino?oueny ? ai?noo nae?aoi?iiai lg A a neei?. Ia aeaeue, oai??, ye? i?eeiaee o/anoue o iaoiio aeine?aeaeaii? ia iiaiaeeeeny a aeinoaoi?e e?eueeino? (uia aoa noaoenoe/ia a??ia?aeiee iaoa??ae) ia iaiaeii?aciaa ianoaaeaiiy oeoieiaiai ai?noo oiieei ciiaeii aai ?I-iao?ii, oiio ie ia i?eaiaeeii iaoa??ae?a ii ai?noo nae?aoi?iiai lg A o iueiio. *a?ac aeaa oeaei? oai?? aoee ianoaaeai? ca?aeii i?aaenoaaeai?e aeua noai?. Oaeiai neiioiio, ye a?eue, ia aoei o aeiaeiiai, eenea ?aao?a?oaoe?y aoea o 2 oai?eo (2,17%), eaaeee nooi?iue ia/?? - o 5 oai?eo iaio a?oi (5,43%), aea e?euee?noue oai?eo c eaaeei nooiaiai ioaeioe a iaio a?oiao aoea ??cei ca?eueoaia ? neeaaeaea a 4 a?oi? - 16 (34,04%) a a 5 - 21 (46,66%). ? oi/a oeae neiioii o oai?eo aoa ae?aaeaiee o eaae?e i??? a a?eueoino? niinoa?aaeaiiyo, a?i na?ae/eoue i?i oa, ui o oai?eo i?e ia?i?aeueiiio i?eeii? aioea?ioeea a aeinoaoiuei aaeee?e aeic? (4 a?oia) ? aioea?ioeea ?acii c iao?ii?aeacieii (5 a?oia) a?aei?/a?oueny iia?/iee aoaeo o aeaeyae? ioaeioe. Oaeiae o 7 oai?eo c 5 a?oie (14,89%) ?nioaaa iai?e?iiee iaoaeaaee i?eniae a ?io?, iniaeeai ia ae?oaiio oeaei? e?eoaaiiy. I?e aiaeineii?/iiio ianoaaeaii? caai?iiy ae?aceiaiai aeaoaeoo /a?ac 2 oeaei? e?eoaaiiy aoei iaeaea o 90% niinoa?aaeaiue. An?i oai?ei e?eoaaiiy aoei i?eei?i/aii e i?ecia/aii eiio?ieueia ianoaaeaiiy OAAeN ? “aeeoaeueiee oano” /a?ac 5-6 oeaei?a i?ney cae?i/aiiy e?eoaaiiy. ?acoeueoaoe aiaeineii?/iiai ianoaaeaiiy /a?ac 4 oeaei? i?ney cae?i/aiiy “iiaea?eii?” oa “iio??eii?” oa?ai?? iieacaee, ui a?aenioie caai?iiy a 4 a?oi? neeaa 95,55% ? a5 - 100%. An?i oai?ei 4 oa 5 a?oie i?ney cae?i/aiiy e?eoaaiiy /a?ac 4-5 oeaei?a aoei i?iaaaeaii eiio?ieueia ianoaaeaiiy ia a?aaeeeaoe?th Helicobacter pylori “aeeoaeueiei” oanoii. “Iiaea?eia” oa?ai?y i?ecaiaeeea aei a?aaeeeaoe?? iaioa, i?ae o 50% (46,67%), a “iio??eia”, yea aaaaea?oueny o anueiio na?o? “aoaeiiii”, anueiai o 72,72%. Noiniaii noaio iieaciee?a ?ioi?oaoo, oi oaaioeeoa?iee ?iaeaen a 4 a?oi? oi/a ? ca?eueooaaany, aea caeeoaany a??ia?aeii ieae/ei a?ae iieaciee?a eiio?ieueii? a?oie. O oai?eo 5 a?oie a?i a??ia?aeii i?aeaeueany ? ia a?ae??ciyany a?ae eiio?ieueiiai ??aiy. A?aeiinii i?o?ineiueiai oao?acieiaiai oanoo, oi eiai iieacieee oi/a ? cieaeoaaeeny, aea i?iaeiaaeoaaee caeeoaoeny a??ia?aeii aeueie a iaio a?oiao o ii??aiyii? c eiio?ieueiith a?oiith. Ai?no nae?aoi?iiai lg A a neei? iaa?oue /a?ac 4-5 oeaei? i?ney i?iaaaeaiiai e?eoaaiiy “iiaea?eiith” oa “iio??eiith” oa?ai??th caeeoa?oueny a??ia?aeii ieae/ei a?ae eiio?ieueieo oeeo?, ui na?ae/eoue i?i oa, ui i?noeaa? ?ioii? ci?ie iaa?oue i?ney onoiaiiy an?o ee?i?/ieo oa aaeoa??ieia/ieo ii?ooaiue i?iaeiaaeothoue caeeoaoeny cieaeaieie. Io?eiai? aeai? a oeeo a?oiao niinoa?aaeaiiy aeicaieythoue c?iaeoe oaeee aeniiaie. Canoinoaaiiy “iiaea?eii?” oa?ai?? o oiio aa??aio?, yeee canoiniaoaaany iaie, iaaeioe?eueia o a?eueoino? oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee, anioe?eiaaii? c Helicobacter pylori. A?aeiinii “iio??eii?” oa?ai??, oi aei ?? i?iaaaeaiiy o an?o oai?eo iaiao?aeii, ii iiaeeeaino?, aeeiioaaoe i?e?ia?ieia?/i? aeine?aeaeaiiy Helicobacter pylori ia /ooeea?noue aei aioea?ioee?a ?, iniaeeai, aei iao?ii?aeacieo. An?o oai?eo, o yeeo a ?acoeueoao? “iiaea?eii?” oa “iio??eii?” oa?ai?? a?aeaoeiny ?oaoethaaiiy “ae?aceiaiai” aeaoaeoo ? aoea a??ia?aeii aeinyaiooa a?aaeeeaoe?y oae?eiaaeoa?ii? ?ioaeoe??, ie niinoa??aaee i?ioyaii 12 i?nyoe?a ia aeieeiaiiy ?aoeeaeea?a oai?iae. C 53 iaoe??io?a, ui niinoa??aaeenue, o?eueee o aeaio oai?eo /a?ac 9 i?nyoe?a aoei “eeane/ia” caaino?aiiy ae?aceiai? oai?iae, yea aoei i?aeoaa?aeaeaia i?e aiaeineii?/iiio ianoaaeaii?, ui neeaei 3,77% a?ae caaaeueii? e?eueeino? in?a. ?acoeueoaoe “aeeoaeueiiai” oanoo o iaio oai?eo aoee iiceoeaieie. Oiio ie ?icaeyaea?ii iaeaeaa aeiaaeee ye ?a?ioaeoe?th oae?eiaaeoa?ii o iaoeo iaoe??io?a. Iai? aoee ciiao i?ie?eiaai? ca “iio??eiith” noaiith, aea aoa canoiniaaiee eiio?ieie, eea?eo?ii?oeei ? aea-iie. Iaoe??ioe ciaoiaeyoueny i?ae iiaeaeueoei niinoa?aaeaiiyi. A e?eoaaii? aeoiaeaiaeueieo ae?acie, anioe?eiaaieo c Helicobacter pylori, iaiao?aeii, ye aacenio oa?ai?th, canoiniaoaaoe “iio??eio” eiia?iaoe?th e?ea?nueeeo cania?a, yea aeeth/a? ?ia?a?oi? i?ioiiiai? iiiie, aaaeaii ae?oaiai iieie?iiy, ? aeaa aioeaaeoa??aeuei? i?aia?aoe. Oea iniaeeai aaaeeeai i?aee?aneeoe, oae ye aeiaaaeaia a?aaeeeaoe?y oae?eiaaeoa?ii? ?ioaeoe?? aeicaieeea i?ioyaii ?ieo cieceoe e?euee?noue ?aoeeaeea?a oai?iae c 60 aei 6,25%, ui ia ii?yaeie iaioa, i?ae i?e iiiioa?ai??. Aeioe?eueii, ia iaoo aeoieo, ? aeeth/aiiy a no/aniee e?eoaaeueiee eiiieaen eeane/ii? “iio??eii?” oa?ai?? i?aia?ao?a caaaeueiicae??iethth/i? ae??, iniaeeai oaeeo, ye ?ioiiiiaeoeyoi?e ? ?aia?aioe, oae ye a?aeiii, ui naia ae?aceiaa oai?iaa, a iaai?e i???, aea? ?ioiio iaaeinoaoi?noue, a canoinoaaiiy aioea?ioee?a, ye i?aaeei, i?eai?/o? ?ioiio nenoaio. AENIIAEE 1. Canoinoaaiiy o oai?eo ia iaoneeaaeiaio ae?aceiao oai?iao “aeeoaeueiiai” oanoo ye aeey aecia/aiiy iayaiino? oae?eiaaeoa?ii? ?ioaeoe??, oae ? ?? a?aaeeeaoe?? iiaeiii aooe a aiaoeaoi?i?e oa ee?i?/i?e i?aeoeoe? iniiaiei ae?aaiinoe/iei oanoii, oae ye a?i ? 100% /ooeeaei, ia?iaaceaiei ? iaoe?aeeeaei. 2. Canoinoaaiiy a iiiioa?ai?? iaoneeaaeiaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee ?ia?a?oi??a oeoieiai? nae?aoe??: Ipicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c020002c0001200000026060f001a00ffffffff0000100 00000f6ffffffc0ffffffb6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00131000100000 0310070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000ffffff-oie?iie?oeea, Ipicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c02000200011200000026060f001a00ffffffff0000100 00000f6ffffffc0fffffff6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00140000100000 0320070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000000000-aeieaoi?a ?aoeaioi??a a?noai?io oa aeieaoi??a i?ioiiiai? iiiie iieacaee ?o aenieo ee?i?/io ? aiaeineii?/io aoaeoeai?noue a onoiaii? neiioii?a oai?iae ? ?oaoethaaiiy ae?aceiaiai aeaoaeoo /a?ac 2 ? 4 oeaei? e?eoaaiiy aano?ioeai?iii, ?ai?oeaeeiii ? eiio?ieieii. A?aenioie ?oaoethaaiiy ae?acie neeaa a?aeiia?aeii /a?ac 2 oeaei? 51,16%, 75,56% ? 90,00%. *a?ac 4 oeaei? e?eoaaiiy a?aenioie ?oaoethaaiiy aoa a?aeiia?aeii 81,60%, 95,56% ? 98,89%. 3. Iaea?eueo ee?i?/ii ? aiaeineii?/ia aoaeoeaiei i?aia?aoii a e?eoaaii? oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee a iiiioa?ai?? ? aeieaoi?e i?ioiiiai? iiiie ae?oaiai iieie?iiy. ?ia?a?oi?e eeneioii? i?iaeoeoe?? oeoiea, ui canoiniaothoueny o e?eoaaii? a iiiioa?ai??, ia i?eaiaeyoue aei a?aaeeeaoe?? oae?eiaaeoa?ii? ?ioaeoe?? a aeiaeiiio aeiaaeeo, ia aieeaathoue oaeiae a??ia?aeii ia ci?ie iieaciee?a caaaeueiiai oa i?noeaaiai ?ioi?oaoo ? ia ciaioothoue e?euee?noue ?aoeeaeea?a ae?aceiai? oai?iae i?ioyaii ?ieo i?ney i?iaaaeaiiai e?eoaaiiy. 4. Anoaiiaeaii, ui ?ia?a?oi?e eeneioii? i?iaeoeoe?? oeoiea aei yeeo ae eean?a aiie ia iaeaaeaee, ia iiaeii? canoiniaoaaoeny a iiiioa?ai?? iaoneeaaeiaii? ae?acee aeaaiaaeoeyoeiaei? eeoee, anioe?eiaaii? c oae?eiaaeoa?iith ?ioaeoe??th. 5. Anoaiiaeaii, ui aeaiooeaeiaaa “iiaea?eia” oa “iio??eia” oa?ai?y ia? ae?aaeaiee ee?i?/iee oa aiaeineii?/iee aoaeo. ?oaoethaaiiy ae?aceiaiai aeaoaeoo ianooia? a?aeiia?aeii a 87,23% ? 88,88%. A?aaeeeaoe?y aoea a?aeiia?aeii a a?oiao a 46,67% ? a 72,72%. Oni?oia a?aaeeeaoe?y oae?eiaaeoa?ii? ?ioaeoe?? i?ecaiaeeoue aei ciaioaiiy e?eueeino? ?aoeeaeea?a o oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee i?ioyaii ?ieo aei 3,77%. 6. Iecueeee a?aenioie a?aaeeeaoe?? Helicobacter pylori o oai?eo, yeei aoea i?iaaaeaia “iiaea?eia” oa?ai?y, ui aeeth/aea iaeei aioenae?aoi?iee oa iaeei aioeaaeoa??aeueiee i?aia?ao, ia aeicaiey? ?aeiiaiaeoaaoe ?? aei ee?i?/iiai canoinoaaiiy a e?eoaaii? oai?eo c iaoneeaaeiaiith ae?aceiaith oai?iaith aeaaiaaeoeyoeiaei? eeoee. 7. Io?eiai? aeai? aeicaieythoue ?aeiiaiaeoaaoe a e?eoaaii? oai?eo ia iaoneeaaeiaio ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee “iio??eio” oa?ai?th c iaia'yceiaei eiio?ieai a?aaeeeaoe?? /a?ac 4-5 oeaei?a i?ney i?iaaaeaii? oa?ai??, aaaeaii “aeeoaeueiei” oanoii, oae ye a?i aeeeth/a? iiaeeea?noue ?a?io?eoaaiiy oai?eo ? eeoa i?e eiai a?aenooiino? iaiao?aeii ei?enooaaoeny ii?oieia?/iei ? oaeaeeei CLO oanoii. I?AEOE*I? ?AEIIAIAeAOe?? 1. Ianoaaeaiiy oa e?eoaaiiy oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee, anioe?eiaaii? c oae?eiaaeoa?iith ?ioaeoe??th, iiaeiii i?iaiaeeoeny ca?aeii c ?a?iiaenueeei i?ioieieii (Iaano?eonueeee eiinainon, 1996 ??e), yeee ia?aaeaa/a? iniiaiei e?eoa???i aee?eiaoaaiiy a?ae ae?aceiai? oai?iae ia eeoa ?oaoethaaiiy ae?aceiaiai aeaoaeoo, aea ? a?aaeeeaoe?th Helicobacter pylori. 2. A ae?aaiinoeoe? ? a?aaeeeaoe?? oae?eiaaeoa?ii? ?ioaeoe?? a ee?i?/i?e oa aiaoeaoi?i?e i?aeoeoe? iiaeiai oe?iei canoiniaoaaoeny “aeeoaeueiee” oano, yeee ? “cieioei” noaiaea?oii ? aea? iiaeeea?noue ia o?eueee nei?ioeoe e?euee?noue aiaeineii?/ieo ianoaaeaiue, aea ? caanoe aei ioey ?a?ioaeoe?th o iaoe??io?a, ui ianoaaeeeenue. 3. Eeneioicieaeoth/? i?aia?aoe, aei yeeo a?oi aiie a ia iaeaaeaee (naeaeoeai? Ipicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c020002c0001200000026060f001a00ffffffff0000100 00000f6ffffffc0ffffffb6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00131000100000 0310070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000000000-oie?iie?oeee, aeieaoi?e i?ioiiiai? iiiie), ia iiaeii? canoiniaoaaoeny a iiiioa?ai?? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee anioe?eiaaii? c oae?eiaaeoa?iith ?ioaeoe??th, /a?ac oa, ui aiie ia i?eaiaeyoue aei a?aaeeeaoe?? Helicobacter pylori ? ia ciaioothoue e?euee?noue ?aoeeaeea?a. Iaea?eueo aoaeoeaieie eeneioicieaeoth/eie i?aia?aoaie ? ?ia?a?oi?e i?ioiiiai? iiiie ae?oaiai iieie?iiy. A eiiieaen? oa?ai?? oai?eo ia ae?aceiao oai?iao ?o canoinoaaiiy iaea?eueo aeioe?eueia, oiio ui aiie ia aieeaathoue ia nenoaio oeeoio?ii P-450 ? ia aeeeeeathoue ci?ie ae?? ?ioeo e?ea?nueeeo cania?a, ui canoiniaothoueny a eiiieaeniiio e?eoaaii?. 4. Canoinoaaiiy a e?eoaaii? oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee anioe?eiaaii? c oae?eiaaeoa?iith ?ioaeoe??th ye aacenii? “iiaea?eii?” oa?ai??, ui aeeth/a? ?ia?a?oi? i?ioiiiai? iiiie ? iaeei aioeaaeoea??aeueiee i?aia?ao, ia aeioe?eueii /a?ac iecueeee (iaioa 50) a?aenioie a?aaeeeaoe?? Helicobacter pylori. Iaea?eueo ?aoe?iiaeueiei ? canoinoaaiiy ye aaceniiai e?eoaaiiy “iio??eiith” oa?ai??th c aeeth/aiiyi aeieaoi?o i?ioiiiai? iiiie oa aeaio aioeaaeoa??aeueieo i?aia?ao?a. I?aea?? aioeaaeoa??aeueieo i?aia?ao?a iaiao?aeii i?iaiaeeoe ii i?e?ia?ieia?/iei iieacieeai /ooeeaino? Helicobacter pylori. Caeaaeii a?ae ii?oieia?/iiai noaio neeciai? iaieiiee oeoiea, ?ioi?oaoo, iayaiino? noiooi?o caoai?thaaiue iaiao?aeii aeiaaaeyoe aei eo?no e?eoaaiiy e?ea?nuee? caniae ?ioeo a?oi: ?aia?aioe, ?ioiiiiaeoeyoi?e oiui. Nienie iioae?eiaaieo aaoi?ii i?aoeue ca oaiith aeena?oaoe?? 1. Ia?aaea?ee A.A., Oea/ N.I., Oeaaoeia A.A., Oaaoe I.E., ssoeaiei I.A. sscaaiiay aieaciue eee iaioe/aneay ycaa // Caei?iauea - Iiiia?aoey - Eeaa - 1997 - 158n. 2. Ia?aaea?ee A.A., Oea/ N.I., Ia?aaea??e I.A. Aeeaaiinoeea e ea/aiea o?iie/aneiai aano?eoa, ycaaiiie aieacie aeaeoaeea, ycaaiiie aieacie aeaaiaaeoeaoeia?noiie eeoee, ceiea/anoaaiiie eeioiiu, aieacie Iaiao?ea, aucaaiiuo eioaeoeeae Helicobacter pylori a aii?inao e ioaaoao aano?iyioa?ieiaa a?a/o iauae i?aeoeee e iaoeeaioo - iiiia?aoey - Eeaa - 1999 - 160n. 3. Ia?aaea?ee I.A. Aeuoaoaeueiua oanou a aano?iyioa?ieiaee // Eaaa?aoi?iay aeeaaiinoeea - N3 - 1998 - n.48-50. 4. I???ae???e A.A., I???ae???e I.A., Oea/ N.I. A?ae aaiethoe?? ciaiue i?i oae?eiaaeoa?io ?ioaeoe?th, ye iniiaii? i?e/eie aano?iaeoiaeaiaeueieo caoai?thaaiue, aei i?iaeai a nenoai? ioi?ii? caei?ia’y // Ee?i?/ia oa?iaoe?y - Oii 3 - ? 1 - 1999 - n.11-13. 5. Ia?aaea?ee I. A. Nia?aiaiiia ianeaaeiaaiea e ea/aiea aieueiuo iaineiaeiaiiie ycaaiiie aieacie aeaaiaaeoeaoeia?noiie eeoee // Caei?iauea e ieoaiea - N 3-4 - 1998 - c.5-7. 6. Ia?aaea?ee A.A., Oea/ N.I., ?aeiaa?o A.E., Oiieia A.A., Oeioeei A.I., Ia?aaea?ee I.A., Aieaiaa E.TH., Naeoaiiaa N.Ae., Oaaoe I.A., Oeauaiei A.A. Nia?aiaiiua aniaeou iaoiaaiaca e iiaua iiaeoiaeu e ea/aieth caaieaaaiee aano?iaeoiaeaiaeueiie ciiu, annioeee?iaaiiuo n ieei?e/aneei oaeeeiaaeoa?eicii // Iaoa?eaeu XIV nuacaea oa?aiaaoia Oe?aeiu - Eeaa - 1998 - n.407-409. 7. Oaaoeue I.?., *ie? A.I., I???ae???e I.A., Oaaei?iaa I.A., I??iiaoeue A.?. Eaaiaoae o oa?iaeioa?ai?? ae?aceiai? oai?iae oeoieo aeaaiaaeoeyoeiaei? eeoee // Iaoa?eaeu XIV nuacaea oa?aiaaoia Oe?aeiu - Eeaa - 1998 - n.437-474 AIIOAOe?ss Ia?aaea??e 0.A. Ii??aiyeueia ee?i?/ia aoaeoeai?noue aeayeeo no/anieo i?aia?ao?a o e?eoaaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca oaoii 14.01.02-aioo??oi? oai?iae. Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. aeaae. I. I.Aiaiiieueoey I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie. Ee?a 1999 ??e Aeena?oaoe?y i?enay/aia ieoaiiyi oaeineiiaeaiiy ae?aaiinoeee ? e?eoaaiiy oai?eo ia iaoneeaaeiaio ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee oeyoii ii??aiyeueiiai aea/aiiy ee?i?/ii? aoaeoeaiino? aioenae?aoi?ieo i?aia?ao?a c ??cieie iaoai?ciaie ae?? ye o iiiioa?ai??, oae ? a ii?aeiaii? c ??cieie aioeaaeoa??aeueieie i?aia?aoaie. Aia?oa aea/aii aieea ??cieo eean?a aioenae?aoi?ieo i?aia?ao?a (naeaeoeaiiai Mpicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c020002c0001200000026060f001a00ffffffff0000100 00000f6ffffffc0ffffffb6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00131000100000 0310070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000000000-oie?iieeoeea, aieieaoi?a Ipicscalex10001000900000390000000020017000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c02000200011200000026060f001a00ffffffff0000100 00000f6ffffffc0fffffff6000000c00100000b00000026060f000c004d6174685479706 50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6 57720526f6d616e2043797200ccdd040000002d01000009000000320ac00140000100000 0320070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000 00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000 003000000000000000000-?aoeaioi??a a?noai?io ? aeieaoi??a i?ioiiiai? iiiie) ia a?aaeeeaoe?th Helicobacter pylori o oai?eo ia ae?aceiao oai?iao ca aeiiiiiaith “aeeoaeueiiai oanoo”. Ia iniia? i?iaaaeaieo aeine?aeaeaiue c?iaeaii aeniiaie i?i oa, ui aeiaeai c o?ueio ia?ae?/aieo eean?a aioenae?aoi?ieo i?aia?ao?a ia iiaea ? ia iiaeiai canoiniaoaaoeny o aeaeyae? iiiioa?ai?? o oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee, anioe?eiaaii? c Helicobacter pylori. E?eoaaiiy oaeeo oai?eo ia iiaea cae?enithaaoeny ? “iiaea?eiith” oa?ai??th, yea aeeth/a? aeieaoi? i?ioiiiai? iiiie oa iaeei aioeaaeoa??aeueiee i?aia?ao, o ca'yceo c ?? iecueeith ee?i?/iith aoaeoeai?noth i?ioe oae?eiaaeoa?ii? ?ioaeoe??. Iaea?eueo ia?niaeoeaiee iaoiae oa?ai?? o oai?eo ia ae?aceo - oea canoinoaaiiy i?i?ioi o?ueio i?aia?ao?a - aeieaoi??a i?ioiiiai? iiiie ae?oaiai iieie?iiy oa aeaio aioeaaeoa??aeueieo i?aia?ao?a, aea?? yeeo iaiao?aeii i?iaiaeeoe oeyoii i?e?ia?ieia?/iiai aecia/aiiy /ooeeaino?, /a?ac ?acenoaioi?noue aeayeeo ooai?a Helicobacter pylori aei aaaaoueio aioeaaeoa??aeueieo i?aia?ao?a. Aia?oa c?iaeaii aeniiaie i?i oa, ui eiio?ieue a?aaeeeaoe?? oa ?oaoethaaiiy “ae?aceiaiai aeaoaeoo” o aeaii? eaoaai??? oai?eo aeinoaoi?e i?iaaaeaiiyi eeoa “aeeoaeueiiai” oanoo. Eeth/ia? neiaa: ae?aceiaa oai?iaa aeaaiaaeoeyoeiaei? eeoee, “aeeoaeueiee” oano, e?eoaaiiy, a?aaeeeaoe?y, Helicobacter pylory. AIIOAOeEss Ia?aaea?ee I. A. N?aaieoaeueiay eeeie/aneay yooaeoeaiinoue iaeioi?uo nia?aiaiiuo i?aia?aoia a ea/aiee ycaaiiie aieacie aeaaiaaeoeaoeia?noiie eeoee - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.02 – aioo?aiiea aieacie. Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei. A. A. Aiaiiieueoea Ieienoa?noaa Cae?aaiio?aiaiey Oe?aeiu. Eeaa - 1999 aiae. Aeenna?oaoeey iinayuaia aii?inai niaa?oainoaiaaiey ea/aiey aieueiuo iaineiaeiaiiie ycaaiiie aieaciueth aeaaiaaeoeaoeia?noiie eeoee, iooai n?aaieoaeueiiai eco/aiey aeeaaiinoe/aneeo aiciiaeiinoae “aeuoaoaeueiiai” oanoa e eeeie/aneie yooaeoeaiinoe aioenae?aoi?iuo i?aia?aoia n ?acee/iuie iaoaieciaie aeaenoaey eae a iiiioa?aiee, oae e a ni/aoaiee n ?acee/iuie aioeaaeoa?eaeueiuie i?aia?aoaie. Aia?aua a ioe?uouo iaaethaeaieyo e “aeaieiui”, “neaiui” iaoiaeaie eco/aii aeeyiea o?ao ?acee/iuo eeannia aioenae?aoi?iuo i?aia?aoia (naeaeoeaiiai oieeiieeoeea, aeieaoi?a Hpicscalex1000100090000038d000000020015000000000005000000090200000000040 0000002010100050000000102ffffff00040000002e01180005000000310201000000050 000000b0200000000050000000c02200200011200000026060f001a00ffffffff0000100 00000eaffffffa6ffffffea000000c60100000b00000026060f000c004d6174685479706 50000500015000000fb0220ff0000000000009001000000000402001054696d6573204e6 57720526f6d616e000083040000002d01000008000000320ae0013d000100000032000a0 0000026060f000a00ffffffff01000000000010000000fb021000070000000000bc02000 000cc0102022253797374656d00cc040000002d01010004000000f001000003000000000 00000-?aoeaioi?ia aenoaieia e aeieaoi?a i?ioiiiie iiiiu aoi?iai iieieaiey) ia y?aaeeeaoeeth Helicobacter pylori o aieueiuo ycaaiiie aieaciueth “aeuoaoaeueiui” oanoii. Onoaiiaeaii, /oi “aeuoaoaeueiue” oano aeieaeai caieiaoue oeaio?aeueiia ianoi a aeeaaiinoeea, y?aaeeeaoeee e ecea/aiee aieueiuo n iaineiaeiaiiie ycaaiiie aieaciueth aeaaiaaeoeaoeia?noiie eeoee, annioeee?iaiie n Helicobacter pyloti. Iiaeoaa?aeaeaii, /oi “aeuoaoaeueiue” oano ia?yaeo n ii?oieiae/aneei oanoii yaeyaony “cieioui noaiaea?oii” a aeeaaiinoeea e eiio?ieai ca y?aaeeeaoeeae oaeeeiaaeoa?iie eioaeoeee. Iaeiaei eiaao oi i?aeiouanoai, /oi ii iaeiaaceaai, ia iianai, aaca?aaeai e ia aucuaaao ieeaeeo iai?eyoiuo eee iiai/iuo yaeaiee o ianeaaeoaiuo aieueiuo. Ia iniiaaiee i?iaaaeaiiuo enneaaeiaaiee naeaeai auaiae i oii, /oi ie iaeei ec o?ao ia?a/eneaiiuo eeannia aioenae?aoi?iuo i?aia?aoia ia iiaeao e ia aeieaeai i?eiaiyoueny a aeaea iiiioa?aiee o aieueiuo n ycaaiiie aieaciueth aeaaiaaeoeaoeia?noiie eeoee, annioeee?iaaiie n Helicobacter pylori. Ea/aiea oaeeo aieueiuo ia iiaeao inouanoaeyoueny e “aeaieiie” oa?aieae, aeeth/athuae aeieaoi? i?ioiiiie iiiiu e iaeei aioeaaeoa?eaeueiue i?aia?ao, aaeaeo aa ieceie eeeie/aneie yooaeoeaiinoe ii y?aaeeeaoeee oaeeeiaaeoa?iie eioaeoeee. Iaeaieaa ia?niaeoeaiue iaoiae oa?aiee aieueiuo ycaaiiie aieaciueth - yoi i?eiaiaiea ieieioi o?ao i?aia?aoia: aeieaoi?a i?ioiiiie iiiiu aoi?iai iieieaiey e aeaoo aioeaaeoa?eaeueiuo i?aia?aoia, iiaeai? eioi?uo iaiaoiaeeii i?iaiaeeoue iooai iee?iaeieiae/aneiai ii?aaeaeaiey /oanoaeoaeueiinoe aaeaeo ?acenoaioiinoe iiiaeo ooaiiia Helicobacter pylori ei iiiaei aioeaaeoa?eaeueiui i?aia?aoai. Aia?aua naeaeai auaiae i oii, /oi eiio?ieue y?aaeeeaoeee e ?oaoeaaaiey “ycaaiiiai aeaoaeoa” o aeaiiuo eaoaai?ee aieueiuo aeinoaoi/ai i?e i?iaaaeaiee iaeiiai “aeuoaoaeueiiai” oanoa e i?iaaaeaiea eiio?ieueiie oea?iaano?ineiiee ia oieueei ia iaycaoaeueii, ii e ia aeaeaoaeueii, iineieueeo aiciiaeia ?aeioaeoeey i?e i?iaaaeaiee aeeaaiinoe/aneie i?ioeaaeo?u. Onoaiiaeaii, /oi ninoiyiea iauaai e iniaaiii ianoiiai eiioieoaoa o aieueiuo iinea i?iaaaeaiey eco/aiiuo noai y?aaeeeaoeee ia ainnoaiaaeeaaaony a iieiii iauaia, e aeey aai ii?iaeecaoeee o aieueiuo o?aaoaony i?eiaiaiea a eiiieaeniii ea/aiee aeiiieieoaeueiuo eiioiiiiaeoee?othueo n?aaenoa. Iieacaii, /oi oniaoiay y?aaeeeaoeey Helicobacter pylori o aieueiuo i?eaiaeeo e oiaiueoaieth eiee/anoaa ?aoeeaeeaia a oa/aiee aiaea iaaethaeaiey aei 3,77%. Eeth/aaua neiaa: ycaaiiay aieaciue aeaaiaaeoeaoeia?noiie eeoee, “aeuoaoaeueiue” oano, ea/aiea, y?aaeeeaoeey, Helicobacter pylory. ANNOTATION Perederiy O.V. Comparative clinical efficacy of some modern preparations in the treatment of duodenal ulcer disease - manuscript. Thesis for application for scientific degree of Candidate of Medical Science, speciality 14.01.02. – Inner Diseases. A.A. Bohomolez National Medical University Ministry of Health Care of Ukraine. Kyiv-1999. The leading issue in this thesis is improvement of treatment regimens for patients with non - complicated duodenal ulcer disease, by comparative studying the clinical efficacy of antisecretory preparations with different action mechanisms in monotherapy, as well as in combination with different antibiotics. For the first time, the effects of three different classes of antisecretory agents (selective cholinolytic, histamine H2- receptors blockator, and proton pump blockator) on eradication of Helicobacter pylori in patients with ulcer diseases were studied by “breath test”. Concluding the held research it can be inferred that non of the described three classes of antisecretory agents should be used as a monotherapy in patients with Helicobacter pylori- associated duodenal ulcer disease. Such patients neither can be treated with dual therapy, including proton pump blockator and one antibiotic, because of low efficacy in eradicating Helicobacter pylori infection. The most reliable method of therapy in ulcer patients is usage of minimum of three preparations: proton pump blockator (II generation) and two antibiotics, which should be defined by microbiological sensitivity testing, in respect with resistance of many Helicobacter pylori strains to many antibacterial preparations. For the first time, the conclusion can be made here, that eradication and cicatrization of “ulcer defect” in given categories of patients. Key words: duodenal ulcer disease, breath test, treatment, eradication, Helicobacter pylori. I?aei. aei ae?oeo 16.03.99. Oi?iao 60x90/16. Ae?oe. ion. Iai?? ion. ?1. Ae?oe. a?e. 2,125. Oe?aae 100 i?ei. Cai 393 Ae?oe. ICC. i.Ee?a, aoe. Eenaiea, 6.

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