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Порівняльна клінічна ефективність деяких сучасних препаратів у лікуванні виразкової хвороби дванадцятипалої кишки: Автореф. дис… канд. мед. наук / О

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20

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao

?i. N. ?. Aai?a??anueeiai

I???ae???e Ieueaa Ay/aneaa?aia

OAeE 616.342-002.44:615.243

Ii??aiyeueia ee?i?/ia aoaeoeai?noue aeayeeo no/anieo i?aia?ao?a o
e?eoaaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee

14.01.02 – aioo??oi? oai?iae

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

N?ioa?iiieue – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i. aeaaeai?ea
I.I.Aiaiiieueoey ia eaoaae?? oaeoeueoaonueei? oa?ai?? ? 2.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? A?eoi? A?eai?iae/
Eeciaoa – caa?aeoth/ee eaoaae?ith oaeoeueoaonueei? oa?ai?? ?2
Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Aiaoie?e Noai?neaaiae/ Na?ioeeoeeee,
caa?aeoth/ee eaoaae?ith aini?oaeueii? oa?ai?? ?2 Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. I.I.Aiaiiieueoey

aeieoi? iaaee/ieo iaoe, i?ioani? Ieeiea Iie?ea?iiae/ Aoaeae,
caa?aeoth/ee eaoaae?ith oa?ai?? ?1 oa aano?iaioa?ieia?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe E?einueeiai aea?aeaaiiai oi?aa?neoaoo ?i.
N.?.Aai?a??anueeiai.

I?ia?aeia onoaiiaa: ?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y.

Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo aano?iaioa?ieia?? IIC Oe?a?ie.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 20 ea?oiy 1999 ?. i 14 aiae. ia
can?aeaii? Niaoe?ae?ciaaii? a/aii? ?aaee E 56.600.01 E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?.Aai?a??anueeiai (333006,
i.N?ioa?iiieue, aoe. Eai?ia, 5/7).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?.Aai?a??anueeiai.

Aaoi?aoa?ao ?ic?neaiee 18 aa?aciy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe, i?ioani?
I.O.Iaco?aoeue

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie aeine?aeaeaiiy. Ae?aceiaa oai?iaa, iniaeeai
oeeaoeeie aeaaiaaeoeyoeiaei? eeoee i?iaeiaaeo? caeeoaoeny aeoaea
?iciianthaeaeaiei caoai?thaaiiyi, ia yea ca?aeii c aeaieie a?o/eciyieo
oa ca?oa?aeieo a/aieo i?ioyaii aeeooy no?aaeaea? 10-20% aei?ineiai
ianaeaiiy [A.A.Eiia?ia, 1995; I.ss.Aaaae, A.Ae.Oaae??iei, 1997;
R.L.Rushworth, J.I.Westdrook, 1993; P.Sipponen, 1995]. Oai??thoue ia
ae?aceiao oai?iao a iniiaiiio iieiae? oa ethaee na?aaeiueiai a?eo, ?
oiio nioe?aeueia cia/ei?noue i?iaeaie iaaecae/aeii aeniea [A.Sonnenberg,
1995; E.?.A?o?i, 1998]. A inoaii? aeanyoe??//y ??cei ci?ieeenue aeoeaioe
uiaei aei ?yaeo ao?ieia?/ieo oa iaoiaaiaoe/ieo /eiiee?a ae?aceiai?
oai?iae oa ?o ?ie? ye o aeieeiaii? oai?iae, oae ? aeaeoaeaii? a?ae ia?
[I.ss.A?eai?’?a, 1996; E.?.A?o?i oa ni?aaao., 1998; A.?.Caeoeaa, 1998;
G.N.Tytgat, 1997].

Aaaaoi a /iio ci?ieeeny iiaeyaee ia ae?aaiinoeeo, e?eoaaiiy ?
iiaeeeaino? aee?eoaaiiy iaioe/ieo ae?acie [N.I.Oea/, 1998; G.D.Bell at
all, 1995; F.Bazzol at all, 1996], a oaeiae ia i?noea eeneioicieaeoth/eo
i?aia?ao?a, ?o ii?aeiaiiy c ?ioeie caniaaie: niaciie?oeeaie,
?aia?aioaie, aioea?ioeeaie oa ?ioeie o e?eoaaii? oai?eo ia ae?aceiao
oai?iao [I.ss.A?eai?’?a oa ni?aaao., 1995; O.E.Eaieia oa ni?aaao., 1995;
A.E.A?aaai?a oa ni?aaao., 1996;G.D.Bell, J.M.Gotz at all, 1995].

Iiaeyaee a/aieo ia ?ieue eeneioiino? oa ?ioaeoe?? o aeieeiaii? ye naii?
ae?acee, oae ? ?? aaaaoi/eneaiieo oneeaaeiaiue oa iiaeeeaino?
?aoeeaeoaaiiy iiee aeineoue noia?a/eea? oa iaiaeiicia/i?
[E.A.Eoae?yaoeaaa, 1998; G.D.Bell, 1996; T.Shimizu at all, 1996;
M.Rovizza at all, 1998]. Ca?aene ? aaeeea e?euee?noue niinia?a
ae?aaiinoeee oa cania?a e?eoaaiiy ? i?io?eaeoeee iaoneeaaeiaii?
ae?aceiai? oai?iae, yea anioe?th?oueny c Helicobacter pylori, a oiio
/ene? ? o??o?a?/ieo [A.A.Aoae??a oa ni?aaao., 1995; E.I.Iia/ai, 1997;
ss.N.Oeeiia?iai, 1998; L.Deodhar, 1996].

Aea a?eueo?noue a/aieo, iniaeeai a ?a?ii?, NOA, Eaiaae? ? Aano?ae??
noeey?oueny aei aeoiee, ui no?eea ?oaoethaaiiy ae?aceiaiai aeaoaeoo
iiaeeeaa eeoa a ?acoeueoao? cieaeaiiy eeneioii?iaeoeoe?? oeoiea oa
a?aaeeeaoe?? oae?eiaaeoa?ii? ?ioaeoe?? [F.Lanza et all, 1996; A.H.Soll,
1996, A.Axon, D.Forman, 1997], ? i?iiiiothoue aeey oe??? iaoe ??ci?
ii?aeiaiiy aioenae?aoi?ieo oa aioeaaeoa??aeueieo i?aia?ao?a [A.N.Eia?iia
oa ni?aaao., 1995; A.Axon at all, 1997; P.Malfertheiner at all, 1997].

Ana a?eueoa aeine?aeiee?a ieoooue i?i iiaeeea?noue aee?eiaoaaiiy
iaoneeaaeiaii? aeoiaeaiaeueii? ae?acee [E.?.A?o?i, 1998; A.?.Caeoeaaa,
1998; M.Buckley at all, 1997] ? iathoue ia oaac? i?e oeueiio
?oaoethaaiiy ae?aceiaiai aeaoaeoo, a?aaeeeaoe?th Helicobacter pylori oa
a?aenooi?noue caaino?aiue i?ioyaii ye iaeiaioa 1 ?ieo [A.?.Caeoeaaa,
1998; H.X.Xia, N.J.Talley, 1996; P.Michetti at all, 1996].

Oei a?eueoa o a?o/eciyi?e e?oa?aoo?? ? i?aeoeoe? iaa?oue inoaii?o ?ie?a,
ie aa/eii o e?eoaaii? a iniiaiiio o?aaeeoe?eiee i?aeo?ae, yeee iniiaaiee
ia oiio, ui “ae?aceiaa oai?iaa ? o?ii?/iith ?aoeeaeeaoth/ith oai?iaith c
i?ia?anoth/ei ia?aa?aii oa aeieeiaiiyi aaaaoi/eneaiieo oneeaaeiaiue o
oai?iai” [?.?.Aeaaoy?ueiaa, I.A.Oa?/aiei, 1995; E.I.Iia/ai, 1997].

O a?o/eciyi?e e?oa?aoo?? ie ia cono??ee ?iaioe ii aea/aiith iaeaeeae/eo
oa a?aeaeaeaieo ?acoeueoao?a ae?aaiinoeee oe?iiino? “aeeoaeueiiai” oanoo
ee?i?/ii? aoaeoeaiino?, oaeaeeino? ?oaoethaaiiy ae?aceiaeo aeaoaeo?a,
iiiiaeaiiy ii?ooaieo iieaciee?a ?ioi?oaoo oa ciaioaiiy e?eueeino?
?aoeeaeea?a i?ney iiiioa?ai?? iaea?eueo neeueieie aeieaoi?aie oeoieiai?
nae?aoe??, ui iae/ano?oa canoiniaothoueny a oaia??oi?e /an o e?eoaaii?
oa i?io?eaeoeoe? ?aoeeaeea?a ae?aceiai? oai?iae. Oaeiae iai a?aeiia
iaaaeeea e?euee?noue ?ia?o oe?a?inueeeo a/aieo, ui i?iaaaeeeeny ia
?a?iiaenueeiio (ca?aeii Iaano?eonueeith oaiaeith) ??ai? ae?aaiinoeee oa
eiio?ieth ca ?acoeueoaoaie e?eoaaiiy ii oae caai?e iaoiaeeoe?
“iiaea?eii?”, “iio??eii?” oa “/aoaa?oii?” oa?ai??, eio?? aeicaieeee a
oe?iei ?aeiiaiaeoaaoe aei ee?i?/ii? i?aeoeee o? /e ?io? ii?aeiaiiy
??cieo i?aia?ao?a [I.ss.Aaaae, A.Ae.Oaae??iei, 1997; N.I.Oea/, 1998].

Eeneioi?noue ai?noo oeoiea i?iaeiaaeothoue ?icaeyaeaoe ia eeoa ye iaeei
?c iniiaieo ao?iiaoiaaiaoe/ieo oaeoi??a aeieeiaiiy ae?aceiai? oai?iae,
aea ? ye oaeoi?, ca aeiiiiiaith aieeao ia yeee iiaeia aeinyaiooe
aee?eiaoaaiiy ae?aceiai? oai?iae iaa?oue i?e iiiioa?ai??
[?.?.Aeaaoy?ueiaa oa ni?aaao., 1994; ?.?.Aeaaoy?ueiaa oa ni?aaao., 1995;
?.?.I?eiea?aa oa ni?aaao., 1995].

Aaaaoi/eneaii? e?oa?aoo?i? aeaea?aea aeacothoue ? ia oa, ui canoinoaaiiy
eeoa ?ia?a?oi??a oeoieiai? nae?aoe?? i?ecaiaeeoue aei a?aaeeeaoe??
Helicobacter pylori o oai?eo ia ae?aceiao oai?iao [I.ss.Aaaae,
?.?.Aeaaoy?ueiaa, A.Ae.Oaae??iei, B.C.Aieiaaanueea, 1996; I.A.Oa?/aiei,
1996], ui o aaaaoueio aeine?aeiee?a aeeeeea? iaa?oioiaaiee noii?a
[A.A.?naeia, 1997; E.E.A?o?i oa ni?aaao., 1998; T.J.Borody at a1l,
1996]. A oie naiee /an aeai? na?oiai? e?oa?aoo?e i?i i?iaaaeaiiy
“iiaea?eii?”, “iio??eii?” oa?ai?? o oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee iieacothoue aaeeeee a?aenioie ia eeoa
oneeaaeiaiue a?ae iaaeeeaiaio?a, ui canoiniaoaaeeny, aea ? iaaaea/ a
a?aaeeeaoe?? Helicobacter pylori [I.Deltere at all, 1995; N.E.Ching at
all, 1996; W.A.De Boer at all, 1996; D.Y.Graham at all, 1996].

Iaoa ?iaioe. Oaeineiiaeaiiy oa?ai?? oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee oeyoii ii??aiyeueiiai aea/aiiy ae?aaiinoe/ieo
iiaeeeainoae “aeeoaeueiiai” oanoo, ee?i?/ii? aoaeoeaiino?
aioenae?aoi?ieo i?aia?ao?a c ??cieie iaoai?ciaie ae?? (naeaeoeaiee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-oie?iie?oee,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-a?noai?iiaeieaoi? oa ?ia?a?oi? i?ioiiiai? iiiie)
ye i?e iiiioa?ai??, oae ? a ii?aeiaii? c aioeaaeoa??aeueieie i?aia?aoaie
a eiiieaeniiio e?eoaaii? iaoneeaaeiaii? ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee.

Caaea/? aeine?aeaeaiiy. 1. Onoaiiaeoe i?noea “aeeoaeueiiai” oanoo a
ae?aaiinoeoe?, a?aaeeeaoe?? ? aee?eiaoaaiiy oai?eo ia iaoneeaaeiaio
ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee.

2. Aea/eoe aieea
Ipicscalex10001000900000390000000020017000000000005000000090200000000040
0000002010100050000000102ffffff00040000002e01180005000000310201000000050
000000b0200000000050000000c020002c0001200000026060f001a00ffffffff0000100
00000f6ffffffc0ffffffb6000000c00100000b00000026060f000c004d6174685479706
50000500017000000fb0220ff0000000000009001000000cc0002001054696d6573204e6
57720526f6d616e2043797200ccdd040000002d01000009000000320ac00131000100000
0310070000a00000026060f000a00ffffffff01000000000010000000fb0210000700000
00000bc02000000cc0102022253797374656d00cc040000002d01010004000000f001000
003000000000000000000-oie?iie?oeea – aano?ioeai?io;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-aeieaoi?o ?aoeaioi??a a?noai?io – ?ai?oeaeeio oa
aeieaoi?a i?ioiiiai? iiiie ae?oaiai iieie?iiy eiio?ieieo ia ee?i?/iee
ia?aa?a oai?iae, oaeaee?noue ?oaoethaaiiy ae?acie a oeeaoeei?
aeaaiaaeoeyoeiaei? eeoee, noai caaaeueiiai oa i?noeaaiai ?ioi?oaoo.

3. Aeyaeoe iiaeeeaino? cacia/aieo a?oi i?aia?ao?a noiniaii a?aaeeeaoe??
Helicobacter pylori i?e i?iaaaeaii? iiiioa?ai??.

4. Anoaiiaeoe /anoioo aeieeiaiiy ?aoeeaeea?a ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee i?ney e?eoaaiiy ??cieie a?oiaie aioenae?aoi?ieo
i?aia?ao?a i?e i?iaaaeaii? iiiioa?ai??.

5. Aea/eoe ae?aaiinoe/io oe?ii?noue “aeeoaeueiiai” oanoo ? ee?i?/io
aoaeoeai?noue aeayeeo iaaeeeaiaioicieo eiia?iaoe?e o oaeaeeino?
?oaoethaaiiy ae?aceiaeo aeaoaeo?a, a?aaeeeaoe?? Ielicobacter pylori,
a?aeiiaeaii? ?ioiiiai noaoono oa ciaioaiiy e?eueeino? ?aoeeaeea?a o
oai?eo ia iaoneeaaeiaio ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee.

Iaoeiaa iiaecia. Aia?oa ae?aaiinoeea ? eiio?ieue a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe?? i?iaiaeeeanue “aeeoaeueiei” oanoii o
ii??aiyii? c ?ioeie ae?aaiinoe/ieie oanoaie: CLO oanoii, ii?oieia?/iei
oa i?e?ia?ieia?/iei aea/aiiyi a?iioao?a. I?aeoaa?aeaeaii, ui
“aeeoaeueiee” oano ? “cieioei noaiaea?oii” o ae?aaiinoeoe? oa eiio?ieai
ca a?aaeeeaoe??th oae?eiaaeoa?ii? ?ioaeoe??. Aia?oa aea/aii aieea o?ueio
eean?a aioenae?aoi?ieo i?aia?ao?a (naeaeoeaiiai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-oie?iie?oeea,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-a?noai?iiaeieaoi?a oa ?ia?a?oi?a i?ioiiiai? iiiie)
ia a?aaeeeaoe?th Helicobacter pylori o oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee iaoiaeii “aeeoaeueiiai” oanoo. Anoaiiaeaii, ui
aeiaeai c i?aia?ao?a, yeee aea/aee, ia i?ecaiaeeoue aei a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe?? a aeiaeiiio c aeiaaee?a. Aia?oa a “iiaea?eiiio
ne?iiio” iaoiae? ianoaaeaiiy a aaaaoiiaoe?iiaeueieo, ioeueoeoeaio?e/ieo
aeine?aeaeaiiyo “iaioii?acie-eiio?ieie i?ioe ?ai?oeaeeio” aoea iieacaia
a?eueo aeniea ee?i?/ia aoaeoeai?noue aeieaoi??a i?ioiiiai? iiiie
ae?oaiai iieie?iiy o ii??aiyii? c aeieaoi?aie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-?aoeaioi??a a?noai?io.

Aia?oa c?iaeaii aeniiaie i?i oa, ui aeiaeai c o?ueio eean?a
aioenae?aoi?ieo i?aia?ao?a ia iiaea ? ia iiaeiai canoiniaoaaoenue o
aeaeyae? iiiioa?ai?? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee, ui
anioe?eiaaia c oae?eiaaeoa??icii. Aia?oa aeine?aeaeaiiy ii aea/aiith
a?aaeeeaoe?? i?iaaaeai? “cieioei aoaeiiii” – aeeoaeueiei oanoii, ui aea?
a??ia?aei?noue io?eiaieo ?acoeueoao?a 100%. E?eoaaiiy oai?eo ia
iaoneeaaeiaio ae?aceiao oai?iao, ui anioe?eiaaia c Helicobacter pylori,
iiaeiii i?iaiaeeoeny eeoa “iio??eiith” oa?ai??th c oaoa’yceiaei
aeeth/aiiyi eeneioiaeieoth/iai i?aia?aoo ae?oaiai iieie?iiy oa aeaio
aioeaaeoa??aeueieo i?aia?ao?a. Eiio?ieue a?aaeeeaoe?? oa aee?eiaoaaiiy o
aeaii? eaoaai??? oai?eo aeinoaoiuei i?iaanoe “aeeoaeueiei” oanoii.
Aia?oa a Oe?a?i? canoiniaaii aeey ae?aaiinoeee oae?eiaaeoa?ii? ?ioaeoe??
“aeeoaeueiee oano” ? iieacaii, ui a?i ? “cieioei noaiaea?oii” o
ae?aaiinoeoe? Helicobacter pylori oa ?? a?aaeeeaoe??.

I?aeoe/ia cia/aiiy. Aia?oa io?oe?eii a iaoiaee/ieo ?aeiiaiaeaoe?yo
I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie (1998 ?.) cai?iiiiiaaii
i?iaiaeeoe ae?aaiinoeeo oa e?eoaaiiy oai?eo ia ae?aceiao oai?iao ca?aeii
c ?a?iiaenueeei i?ioieieii (Iaano?eonueeee eiinainon), yeee ia?aaeaa/a?
i?e e?eoaaii? ae?aceiai? oai?iae ia eeoa ?oaoethaaiiy ae?aceiaiai
aeaoaeoo, aea ? oaoa’yceiay a?aaeeeaoe?th oae?eiaaeoa?ii? ?ioaeoe??.

Aia?oa i?aaenoaaeai? aeai? i?i iaaeioe?euei?noue e?eoaaiiy
iaoneeaaeiaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee anioe?eiaaii?
c Helicobacter pylori eeoa aeieaoi?aie eeneioii? i?iaeoeoe?? oeoieiaiai
ai?noo a iiiioa?ai??, aei yei? a a?oie aiie ia iaeaaeaee, aac
aioea?ioee?a, a?niooiaeo i?aia?ao?a, iao?ii?aeacieo oa ?ioeo, c iiaeyaeo
ia a?aenooi?noue ?o aeinoaoiuei? aoaeoeaiino? ii a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe??.

Aia?oa o a?aee?eoeo niinoa?aaeaiiy oa iiaea?eiei “ne?iei” iaoiaeii
iieacaia ia?aaaaa aeieaoi?a i?ioiiiai? iiiie ae?oaiai iieie?iiy –
eiio?ieieo iaae ?ioeie aeieaoi?aie oeoieiai? nae?aoe??: naeaeoeaiei
aeieaoi?ii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-oie?iie?oeeii – aano?ioeai?iii ? aeieaoi?ii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-?aoeaioi??a a?noai?io-?ai?oeaeeiii o oaeaeeino?
?oaoethaaiiy ae?aceiaeo aeaoaeo?a, cieeiaiiy ee?i?/ieo i?iya?a oai?iae.

Aia?oa a Oe?a?i? i?iaaaeaii ianoaaeaiiy ? e?eoaaiiy oai?eo o
a?aeiia?aeiino? c ?a?iiaenueeei i?ioieieii. Io?eiai? ?acoeueoaoe
aeicaieeee ?aeiiaiaeoaaoe ia?oei aoaiii a a?aaeeeaoe?? oae?eiaaeoa?ii?
?ioaeoe?? “iio??eio” oa?ai?th. “Iiaea?eia” oa?ai?y ia iiaeiia
canoiniaoaaoeny o e?eoaaii? oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee anioe?eiaaii? c Helicobacter pylori, oiio ui
aiia aea? aeoaea iecueeee (iaioa 50%) a?aenioie a?aaeeeaoe??
Helicobacter pylori.

?aeiiaiaeiaaii, ii iiaeeeaino?, i?iaiaeeoe i?aea?? aioeaaeoa??aeueieo
iaaeeeaiaio?a noai?i ?iaeea?aeoaeueii, ia iniia? i?e?ia?ieia?/ieo
aeaieo, /a?ac ??cio /ooeea?noue oai?eo aei aioei?e?iaieo i?aia?ao?a.

Io?eiai? i?e ii??aiyeueieo aeine?aeaeaiiyo aeai? aeicaieeee
?aeiiaiaeoaaoe a i?aeoeeo oa?aiaao?a caaaeueii? i?aeoeee oa
aano?iaioa?ieia?a iaea?eueo aoaeoeai? ii?aeiaiiy aioenae?aoi?ieo oa
i?ioei?e?iaieo i?aia?ao?a ??cieo eean?a o e?eoaaii? ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee.

Ooai?aia nenoaia ii ianoaaeaiith oae?eiaaeoa?ii? ?ioaeoe?? o oai?eo ia
ae?aceiao oa iaae?aceiao aeeniain?th a i?no? Ee?a? c canoinoaaiiyi
“aeeoaeueiiai” oanoo oa anoaiiaeaiiyi aioea?ioeei?acenoaioieo
oe?a?inueeeo ooai?a Helicobacter pylori.

Iieiaeaiiy, ui aeiinyoueny ia caoeno.

1. O?aaciee “aeeoaeueiee” oano ? no/aniei, aeniei?ioi?iaoeaiei, c?o/iei
oa aacia/iei caniaii ae?aaiinoeee ye iayaiino?, oae ? a?aaeeeaoe??
oae?eiaaeoa?ii? ?ioaeoe?? o oai?eo ia ae?aceiao oai?iao
aeaaiaaeoeyoeiaei? eeoee.

2. An? i?ioeeeneioi? i?aia?aoe, ui i?aeeyaaee aea/aiith a iiiioa?ai??,
i?enei?ththoue ?oaoethaaiiy ae?acie a aeaaiaaeoeyoeiae?e eeooe?,
anioe?eiaaieo c Helicobacter pylori. Iaea?eueo aoaeoeaieie e?ea?nueeeie
caniaaie c oe??? a?oie ? ?ia?a?oi?e i?ioiiiai? iiiie ae?oaiai iieie?iiy.
Aea eo?niaa e?eoaaiiy eeoa i?ioeeeneioieie i?aia?aoaie ia iiia?aaeaea?
aeieeiaiiy ?aoeeaeea?a oai?iae.

3. Ni?eyth/e oaeaeeiio ?oaoethaaiith ae?aceiaeo aeaoaeo?a a oeeaoeei?
aeaaiaaeoeyoeiaei? eeoee, i?ioeeeneioi? i?aia?aoe cieaeothoue ai?no
Helicobacter pylori a oeoieo, aea, yeui ?o canoiniaoaaoe a iiiioa?ai??,
aiie eeoa cieaeothoue ian?iai?iiy aeoiaeaiaeueii? ciie Helicobacter
pylori, ia i?ecaiaey/e aei a?aaeeeaoe?? Helicobacter pylori. Oaeiae ia
a?aeiiaeththoueny iieacieee caaaeueiiai oa i?noeaaiai ?ioi?oaoo.

4. Io?eiai? a?aeiiino? i?i a?aenooi?noue a?aaeeeaoe?? i?ney iiiioa?ai??
i?ioeeeneioieie i?aia?aoaie c ??ciei iaoai?ciii ae?? noaaeyoue ieoaiiy
i?i ci?ie e?eoaaiiy oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee
canoinoaaiiyi o?eueee i?ioeeeneioieo i?aia?ao?a.

5. Canoinoaaiiy iiaea?eii? oa?ai?? o e?eoaaii? oai?eo ia ae?aceiao
oai?iao aeaaiaaeoeyoeiaei? eeoee iaaeioe?eueii o ca’yceo c iecueeei
a?aenioeii a?aaeeeaoe?? Helicobacter pylori. sse aacenia e?eoaaiiy
iiaeiia canoiniaoaaoenue “iio??eia” oa?ai?y, ui neeaaea?oueny c iaeiiai
eeneioicieaeoth/iai i?aia?aoo, aaaeaii ?ia?a?oi?a i?ioiiiai? iiiie
ae?oaiai iieie?iiy, ? aeaio aioeaaeoa??aeueieo i?aia?ao?a.

6. I?aea?? i?ioei?e?iaieo i?aia?ao?a aeey i?iaaaeaiiy “iio??eii?”
oa?ai?? iiaeiai i?iaiaeeoeny ?iaeea?aeoaeueii ia iniia? aeaieo i?i
/ooeea?noue Helicobacter pylori aei aioeaaeoa??aeueieo cania?a.
Eiio?ieue ca a?aaeeeaoe??th oae?eiaaeoa?ii? ?ioaeoe?? iiaeiai
i?iaiaeeoeny o?aaciei “aeeoaeueiei oanoii”.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Io?eiai? a ?iaio? aeai?
canoiniaothoueny o iaa/aeueiiio i?ioean? ia eaoaae?? oaeoeueoaonueei? oa
aini?oaeueii? oa?ai?? ? 1 ? ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo,
eaoaae?ao oaeoeueoaonueei? oa aini?oaeueii? oa?ai?? E?einueeiai,
A?iieoeueeiai iaaee/ieo oi?aa?neoao?a, eaoaae?ao oa?ai?? oa
aano?iaioa?ieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe.
Oaeiae i?aeoe/i? ?acoeueoaoe ?iaioe canoiniaothoueny a
caaaeueiioa?aiaaoe/ieo oa aano?iaioa?ieia?/ieo a?aeae?eaiiyo i. Ee?aa ?
Oe?a?ie.

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?? aeieeaaeaeeny ia 11
Anana?oiueiio eiia?an? aano?iaioa?ieia?a (i.A?aeaiue, 1998), 14
Oe?a?inueeiio c’?cae? oa?aiaao?a (i.Ee?a, 1998), 4-io ?in?enueeiio
aano?iaioa?ieia?/iiio oeaei? (i.Iineaa, 1998).

Ioae?eaoe?? ca oaiith aeena?oaoe??. Ii oai? eaiaeeaeaonueei?
aeena?oaoe?? iioae?eiaaii 2 iiiia?ao?? oa 5 iaoeiaeo ?ia?o.

Aeaeea?aoe?y ?iaeea?aeoaeueiiai aianeo aeena?oaioa. Iniaeeaee aianie
aeena?oaioa o aeeiiaiiy aeena?oaoe?eii? ?iaioe iieyaa? a oiio, ui a?i
naiino?eii c?iaea iaeyae no/anii? e?oa?aoo?e, aecia/ea iaoo oa caaea/?
?iaioe, naiino?eii i?ia?a ee?i?/i?, eaai?aoi?i? oa ?ino?oiaioaeuei?
ianoaaeaiiy, i?ia?a aiae?c io?eiaieo aeaieo oa ?o noaoenoe/io ia?iaeo.

No?oeoo?a oa ci?no. Aeena?oaoe?y neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, aeaa oa iaoa??aee oa iaoiaee aeanieo aeine?aeaeaiue,
iaaiai?aiiy io?eiaieo aeaieo, aeniiae?a. Nienie e?oa?aoo?e neeaaea?oueny
c 400 aeaea?ae. Aeena?oaoe?y aeeeaaeaia ia 160 noi??ieao iaoeiiieno.
?ethno?iaaia 11 noaiaie oa 40 oaaeeoeyie.

INIIAIEE CI?NO AeINE?AeAEAIUe

Iaoa??aee oa iaoiaee

Ee?i?/ia oa?aeoa?enoeea oai?eo. Aoei ianoaaeaii oa i?ie?eiaaii 328
oai?eo ia ae?aceiao oai?iao aeaaiaaeoeyoeiaei? eeoee o oac? caaino?aiiy
aai aia?oa aeyaeaiith. Ianoaaeaiiy, e?eoaaiiy oa iiaeaeueoa
niinoa?aaeaiiy oai?eo i?iaiaeeeeny a ee?i?eao eaoaae? oaeoeueoaonueei?
oa?ai?? ? 1 oa ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo oa
Oe?a?ii-i?iaoeueeiai i?ioeae?aceiaiai aano?iaioa?ieia?/iiai oeaio?o.

A aeine?aeaeaiiy aeeth/ai? eeoa iaoe??ioe c iayai?noth Helicobacter
pylori, o a?oe? a?ae 18 aei 75 ?ie?a c aiaeineii?/ii i?aeoaa?aeaeaiith
iaoneeaaeiaiith ae?aceith aeaaiaaeoeyoeiaei? eeoee. O an?o ianoaaeaieo
ae?aceia? aeaoaeoe aoee ie?oaei? aai iaaeueii? oi?ie, c iaa?yeeeie,
i?aeiyoeie e?ayie, aeii ae?acee iie?eoi a?eei iaeueioii aai aeiaoi-a?eei
iaeueioii o?a?eio. Oai??, o yeeo niinoa??aaeanue noaae?y ?oaoethaaiiy
ae?acee, a ianoaaeaiiy ia aeeth/aeenue. I?i?iaeuei? ?ici??e ae?aceiaiai
aeaoaeoo neeaaeaee 5 ii, iaeneiaeuei? 20 ii aai ieiuath a?ae 0,5 ni2 aei
2 ni2.

C 328 ianoaaeaieo o 53 (16,1%) ae?aceiaa oai?iaa aoea aeyaeaia aia?oa.
?aooa iaoe??io?a (275) no?aaeaeaea ia ae?aceiao oai?iao ??ciiai nooiaiy
aaaeeino?.

An? oai?? aoee ?iciiae?eai? ia 5 a?oi a?aeiia?aeii aei iinoaaeaieo
caaea/. A ia?o?e a?oi? aoei 45 oai?eo ? an? aiie io?eioaaee aano?ioeai?i
a aeic? 50 ia o?e/? ia aeaiue oa ia i?/. Ianoaaeaiiy i?iaiaeeeeny o
a?aee?eoeo niinoa?aaeaiiyo. Ae?oao a?oio neeaa 91 oai?ee, ui io?eioaaee
?ai?oeaeei, ? o?aoth a?oio neeaee 92 iaoe??ioe, ye? io?eioaaee
eiio?ieie. Ianoaaeaiiy i?ae ae?oaith oa o?aoueith a?oiith aoee
i?iaaaeai? “iiaea?eiei” ne?iei iaoiaeii, yeee i?eioneaa iaciaiiy i?
e?ea?ai, i? oai?ei, ui io?eio? iaoe??io o i?ioean? e?eoaaiiy. Eiio?ieie
i?ecia/aee a aeic? 40 ia uiaeaiii, iaeei ?ac ia aeaiue ca ni?aeaieii.
?ai?oeaeei – iaeei ?ac ia aeaiue aaa/a?? o aeic? 300 ia ia?aae niii.
Oaaeaoee eiio?ieieo, ?ai?oeaeeio oa ieaoeaai aoee c?iaeai? oa oiaeiaai?
cian?i iaeiaeiai, ui aeeeth/aei iiaeeeaino? ?o aecia/aiiy a?coaeueii.
An? aeai? ianoaaeaiiy eaai?aoi?ieo, a?io?i?/ieo, aiaeineii?/ieo oa ?ioeo
ianoaaeaiue caiineeenue a niaoe?aeuei? i?ioieiee oa a?aei?aaeyeeny a i.
Eiinoaioe O?I, aea ia?iaeyeeny. Iio?i a ?icoeo?iaaiiio aeaeyae? ie ?o
io?eioaaee, aiae?coaaee oa aeei?enoiaoaaee o ?iaio?. *aoaa?oo oa i’yoo
a?oio neeaee oai??, yeei i?iaiaeeeinue e?eoaaiiy ??cieie oa?aiaaoe/ieie
eiiieaenaie a aeaio eiia?iaoe?yo. *aoaa?oa a?oia: eiio?ieie ii 40 ia 1
?ac ia aeaiue ?aieii ca ni?aeaieii, aiieneoeee?i ii 500 ia 4 ?ace ia
aiue i?ae /an ?ae? ? ia i?/. Iaeaeaa ia?aia?aoe i?eeiaee i?ioyaii aeaio
oeaei?a. I’yoa a?oia: eiio?ieie ii 40 ia ? ?ac ia aeaiue a?aioe? ca
ni?aeaieii, aiieneoeee?i ii 500 ia 4 ?ace ia aeaiue, iao?ii?aeacie ii
500 ia 3 ?ace ia aeaiue i?ae /an ?ae?. E?eoaaiiy i?ioyaii aeaio oeaei?a.
Oai?? an?o 5 a?oi ianoaaeoaaeenue aei e?eoaaiiy, /a?ac 2 ? 4 oeaei?
e?eoaaiiy oa /a?ac 4-5 oeaei?a i?ney cae?i/aiiy e?eoaaiiy (eiio?ieuei?
ianoaaeaiiy ia a?aaeeeaoe?th Ielicobacter pylori).

An? oai?? ciaoiaeeeeny i?ae niinoa?aaeaiiyi i?ioyaii 18 i?nyoe?a.
Aeoeaia ianoaaeaiiy i?iaiaeeeiny /a?ac 3, 6, 9, 12, 15 oa 18 i?nyoe?a, a
oaeiae i?e eiaeiiio iiaiio ?aoeeaeea?.

Iaoiaee ianoaaeaiiy. Ae?aaiic ae?aceiai? oai?iae aeaaiaaeoeyoeiaei?
eeoee noaaeany ia i?aenoaa? eiiieaeniiai ee?i?/iiai, aiaeineii?/iiai,
?ino?oiaioaeueiiai, i?e?ia?ieia?/iiai ianoaaeaiiy, iniaeeao oaaao
i?eae?eyee aiaiiaco.

An?i oai?ei, e??i caaaeueiii?eeiyoeo ee?i?ei-eaai?aoi?ieo ianoaaeaiue,
i?iaiaeeeeny a?io?i?/i? ianoaaeaiiy e?ia?: caaaeueiee a?eie oa a?eeia?
o?aeoe??, caaaeueiee a?e??oa?i oa eiai o?aeoe??, ia/?ieia? i?iae, oeoei?
e?ia?, aeaeo?ie?oe (eae?e, eaeueoe?e, iao??e, oei?), oieanoa?ei oa
aaoa-e?iii?ioa?aee, eae ia i?eoiaaio e?ia.

An?i oai?ei, yeeo a?ae?a?aee aeey ianoaaeaiiy, i?ney ee?i?/iiai
ianoaaeaiiy i?iaiaeeany “aeeoaeueiee” oano, o?a?iacioaaiaano?ineii?y c
a?iin??th oa iiaeaeueoei ii?oieia?/iei aeine?aeaeaiiyi oaeaeeei CLO
oanoii.

“Aeeoaeueiee oano” c na/iaeiith iaeaaeeoue aei iiaeo ia?iaaceaieo
iaoiae?a ae?aaiinoeee oae?eiaaeoa?ii? ?ioaeoe??. Ia? 100% /ooeea?noue oa
niaoeeo?/i?noue, cian?i iaoe?aeeeaee oa aacia/iee. I?eioeei iaoiaeo
i?aaenoaaeaii ia iaethieo 1. A?i iniiaaiee ia oiio, ui i?ney
ia?i?aeueiiai i?eeiio ?ic/eio na/iaeie a aiaeueneiiaiio nieo, i?/aii?
ia?aae?iaeoeaiei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, o?aaca Helicobacter pylori iaoaaie?co?
i?/aio na/iaeio ? aea?eueiy? i?/aiee aoaeaeeneee aac, yeee aecia/a?oueny
o iia?o??, ui aeaeeoa?oueny /a?ac 30 oaeeei.

A iaoeo aeine?aeaeaiiyo aeey i?iaaaeaiiy aeeoaeueiiai oanoo aoa
aeei?enoaiee ?io?a/a?aiiee ?cioiiiee aiae?caoi? i?iaoeueei? o??ie Wagner
Analysen Technik Vertrebs nenoaie IRIS.

Eeneioiooai?thth/a ooieoe?y oeoiea aecia/aeanue ?I-iao?e/iei iaoiaeii o
an?o oai?eo.

I?eoe?eueia a?iin?y i?iaiaeeeany c 5-7 i?noeue aio?oio, acaeiaae aaeeei?
e?eaecie, ii ia?aaei?e no?ioe? aio?oio, ia 2 ni a?ae
i?ei?i-aeoiaeaiaeueiiai ia?aoiaeo, ?c ciie caiaeaiiy a oeeaoeei?
aeaaiaaeoeyoeiaei? eeoee, ui ioi/o? ae?aceiaee aeaoaeo.

Oaeaeeee o?aaciee aai CLO oano i?iaiaeeany an?i oai?ei.
Aeei?enoiaoaaeeny oae? oano-nenoaie ye Delta West Ltd, Bently, Australia
? Denol oano (Yamanochi).

An?i oai?ei 4 oa 5 a?oi i?iaiaeeee i?e?ia?ieia?/ia aeine?aeaeaiiy, aeey
/iai a?aee a?iioaoe c 4 ae?eyiie, ye? iienai? aeua, aiiiaai?coaaee ?o ca
aeiiiiiaith iaoai?/iiai aeac?ioaa?aoi?a ? aeei?enoiaoaaee aeey iin?ao ia
oieieaaeiee aaa?, yeee aiooaaany ia iniia? a?eo?ao-aaa?o c aeiaeaoeii
10% aeiii?nueei? ethaenueei? e?ia? c naeaeoeaieie aeiaaaeaie
(aioioa?eoeei A-2 iea-e, iae?aeeeniaa eeneioa – 40 iea-ie, aaieii?oeei –
10 iea-ie. Iin?ae ?ieoaoaaee i?ioyaii 5-7-4 ae?a i?e oaiia?aoo?? 37 iN a
iae?iaa?io?eueieo oiiaao) a aiaa?inoao? c aeei?enoaiiyi noi?o? o?i?/ieo
i?aia?ao?a, ui i?noyoue aoiinoa?o c 5% eiioeaio?aoe??th eenith oa 10%
eiioeaio?aoe??th aoaeaeeneiai aaco.

Aei aeaeo Helicobacter pylori a?aeiineee a?aiiaaaoeai? ni??aeaiiae?ai?
aaeoa???, ye? aeaaaee ??no ia iienaiiio na?aaeiaeu? i?ney 5-7 ae?a
eoeueoeaoaaiiy o aeaeyae? iai?ai?ici?eo ae??aieo (ae?aiao?ii 0,5-? ii)
n??oaaoeo eieii?e, ui neioacoaaee o?aaco, eaoaeaco oa ieneaeaco, no?eeeo
aei 40 iea-ie iae?aeeeniai? eeneioe.

An? io?eiai? ?acoeueoaoe aeine?aeaeaiiy aoee ia?iaeai? iaoiaeii
aa??aoe?eii? noaoenoeee. Aecia/aee I-na?aaeiueia?eoiaoe/io,
-na?aaeiueieaaae?aoe/ia a?aeoeeaiiy, m-na?aaeith iiieeeo
na?aaeiueia?eoiaoe/ii?, t-e?eoa??e No’thaeaioa oa ?-??aaiue
a??ia?aeiino?. Oaeiae a ie?aieo aeiaaeeao aeey noaoenoe/ii? ia?iaee
iaoa??aeo aoa canoiniaaiee iaia?aiao?e/iee iaoiae
A?eueeieniia-Iaiia-O?oi?[A.A. Aaieei, A.A. Aoaea?, 1973].

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe

OA ?O IAAIAI?AIIss

Ia ia?oiio aoai? iaie aoei i?iaaaeaii aea/aiiy “aeeoaeueiiai” oanoo a
ae?aaiinoeoe? caoai?thaaiue, ye? anioe?eiaai? c oae?eiaaeoa?iith
?ioaeoe??th oa ?? a?aaeeeaoe??th. Aeey oeueiai o an?o 328 ianoaaeaiiyo
i?iaiaeeeinue aecia/aiiy Helicobacter pylori e?eueeiia iaoiaeaie:
a?noieia?/iei, oaeaeeei CLO oanoii, “aeeoaeueiei” oa a eoeueoo??
oeaieie. I?iaaaeaia ii??aiyiiy io?eiaieo aeaieo iieacaei, ui
“aeeoaeueiee” oano aoa iiceoeaiei o an?o 100% ianoaaeaieo aei e?eoaaiiy
oai?eo, oaeiae 100% iiceoeaiei aoa ? CLO oano, ui noino?oueny
a?noieia?/iiai iaoiaeo, oi a?i aoa iiceoeaiei o 298 (90,24%) oai?eo, a
i?e?ia?ieia?/iiai – o 283 (86,28%). Oaeei /eiii “aeeoaeueiee” oano
iiaeiai aooe iaee?auei i?e i?iaaaeai? ye ae?aaiinoeee, oae ?, iniaeeai,
a?aaeeeaoe?? oae?eiaaeoa?ii? ?ioaeoe??, oiio ui i?e eiai i?iaaaeaii?
aeeeth/aii ?a?io?eoaaiiy oai?iai.

Iio?i aoei i?iaaaeaii ii??aiyeueia aea/aiiy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-oie?iie?oeea (aano?ioeai?io),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-aeieaoi?a ?aoeaioi??a a?noai?io (?ai?oeaeeio) oa
aeieaoi??a i?ioiiiai? iiiie (eiio?ieiea) ia ee?i?/iee ia?aa?a
iaoneeaaeiaii? ae?aceiai? oai?iae aeaaiaaeoeyoeiaei? eeoee, eeneioio
i?iaeoeoe?th oeoiea, noai caaaeueiiai oa i?noeaaiai ?ioi?oaoo oa
oaeaee?noue ?oaoethaaiiy ae?acee oa a?aaeeeaoe?? Helicobacter pylori a
iiiioa?ai??.

Anueiai a oe?e na??? niinoa?aaeaiue aoei ianoaaeaii 228 oai?eo ia
ae?aceo aeaaiaaeoeyoeiaei? eeoee a o?ueio a?oiao. O oai?eo an?o o?ueio
a?oi, ui ianoaaeoaaeenue aei e?eoaaiiy, iaa i?noea a?eue a 100%
aeiaaee?a, i?e/iio, nooi?iue ae?aaeaiino? aoea eeoa aeaio aeae?a:
iii??ia oa aaaeea. Ui noino?oueny ?ioeo neiioii?a ae?aceiai? oai?iae
aeaaiaaeoeyoeiaei? eeoee, ui iaea?eueo /anoi aoaathoue, oi, aiie
?nioaaee ??aeoa a?ae aieth. Eeneo ?aao?a?oaoe?th a?aei?/aee o 163 oai?eo
– 71,49% a?ae an??? e?eueeino? ianoaaeaieo, ia/?th – o 179 (79,5%),
ioaeioo – 116 ( 50,87%) oa aethaioo o 78 (43,21%), i?e/iio nooi?iue
ae?aaeaiino? aeacaieo neiioii?a aoea a?eueoith i??ith iii??ia oa eaaea.

Aeine?aeaeaiiy nae?aoe?? oeoieiaiai nieo ?I-iao?ii aei e?eoaaiiy
iieacaei, ui o 211 oai?eo (92,57%) aoea i?aeaeuaia eeneioiooai?thth/a
ooieoe?y oeoiea, o 14 (7,43%) – ii?iaeueia.

O oai?eo ia ae?aceiao oai?iao o an?o o?ueio a?oiao niinoa??aaeinue
a??ia?aeia cieaeaiiy A-?icaoeiooai?thth/eo ee?oei o ii??aiyii? c
eiio?ieueiith a?oiith (caei?ia? ethaee) ? neeaee a?aeiia?aeii a eiio?ie?
53,2+4,9; a ia?o?e a?oi? 32,6+2,9 (?

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