Мiнiстерство охорони здоров’я України

Львiвський державний медичний унiверситет

ім. Данила Галицького

Naoiiiaa

Ienaia Aaeaioei?aia

OAeE : 616.379-008.64.-02:618.36]-0191.8-08

Ieaoeaioa?ia iaaeinoaoiinoue i?e oeoe?iaiio

aeiaaaoi oa oeyoe ?? ei?aeoei?

14.03.02 — iaoieiai/ia aiaoiiiy

Aaoi?aoa?ao aeena?oaoei?

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Eueaia — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
Aeaieea

Aaeeoeueeiai.

Iaoeia? ea??aieee:

aeieoi? iaaee/ieo iaoe, aeioeaio

IINI?O?EUe TH??e Ieaen?eiae/,

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai,

aeioeaio eaoaae?e iaoieia?/ii? aiaoii??;

aeieoi? iaaee/ieo iaoe, aeioeaio

NA?A??IEI Ieaenaiae? Ieaen?eiae/,

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai,

aeioeaio eaoaae?e aiaeie?eiieia?? c eo?nii ee?i?/ii? oa?iaeieia??.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?

IEOAEETHE ?aai Ieaen?eiae/,

?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y,

caa?aeoaa/ eaoaae?e iaoieia?/ii? aiaoii??;

aeieoi? iaaee/ieo iaoe, i?ioani?

Eooeee Ieaenaiae? Aeieo?iae/,

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai,

caa?aeoaa/ eaoaae?e a?noieia??.

I?ia?aeia onoaiiaa:

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao.

Caoeno a?aeaoaeaoueny”25” a?oaeiy 1998 ?. i 1100aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 35.600.03 o Euea?anueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? ?i. Aeaieea Aaeeoeueeiai (290010, i. Euea?a-10,
aoe. Iaea?nueea,52, aoaeeoi??y eaoaae?e ii?iaeueii? o?c?ieia?? EAeIO).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai (i.
Euea?a, aoe. N?/iaeo No??eueoe?a, 6).

Aaoi?aoa?ao ?ic?neaiee “24” eenoiiaaea 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? a?ieia?/ieo iaoe
II?IC I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue i?iaeaie.

I?iaeaia aaa?oiino? i?e oeoe?iaiio ae?aaao? ?nioaaea caaaeaee, aea
inoaii?i /anii o ca’yceo c? cia/iei c?inoaiiyi /enea oai?eo ?
oaiaeaioe??th aei “iiieiaeaeaiiy” oeueiai caoai?thaaiiy iaaoaa?
iniaeeai? aeooaeueiino?, ianaiia?aae aeey aiaeie?eiieia?a, aeooa??a,
iaae?ao??a, iaa?iiaoieia?a, iaoieiaiaiaoii?a. I?aeoeea naiae/eoue, ui
aeiaaao i aaaioiinoue iaaaoeaii aieeaathoue iaeia ia iaeia (A?yciiaa
?.I., Aoi?iaa A.A., 1995). Iniaeeai iani?eyoeeai aieeaa? oeoe?iaee
aeiaaao iaoa?i ia aioo?ioiueioo?iaiee ?icaeoie ieiaeo, ui ia??aeei
i?ecaiaeeoue aei eiai caaeaae?, oi?ioaaiiy aaae ?icaeoeo, aai ?ioi?
iaoieia??. Oea aeicaiey? aiaeianoe aaaioieo, oai?eo ia oeoe?iaee
aeiaaao, a oaeiae ?oiio aeioae, aei a?oie aenieiai nooiaiy ?eceeo. Oaeei
/eiii, i?iaeaia “oeoe?iaee aeiaaao i aaaioiinoue” ? aeooaeueiith ia eeoa
a iaaee/iiio, aea i a nioeiaeueiiio aniaeoi.

Ia?eiaoaeueia nia?oiinoue i?e oeoe?iaiio aeiaaao? cieceeany c 30-40% aei
10-20%. Ia?eiaoaeueia iaoieiaiy ? nia?oiinoue /anoi coiiaeaii
aeiaaaoe/ieie aia?ii- oa oaoiiaoiyie, a oaeiae oneeaaeiaiiyie
aaaioiinoi, cie?aia iiciii oieneeicii, aaaaoiaiaeaeyi, ii?eiiao?eoii,
aaeeeeie ?ici??aie ieiaeo (sseiaoeiaa A.O., 1993). Aieueoinoue
oneeaaeiaiue aaaioiinoi, iniaeeai a ii?aeiaiii c oeoe?iaei aeiaaaoii,
coiiaeththoue ae?aaeaio ieaoeaioa?io iaaeinoaoi?noue. I?e aea/aiii oei??
i?iaeaie aaaeeeaa cia/aiiy iathoue ani eiiiiiaioe nenoaie
iaoe-ieaoeaioa-ieiae, yei aiaeiiaiaeathoue ca iiaeo?eieo ii?iaeueiiai
aiiainoaco ieiaeo, ye a oiiaao oiciieiai/ii? aaaioiinoi, oae i i?e
iaoieiai? (I?ciaa I.I., Aeaieeaiei A.?., 1998). Ieaoeaioa?ia
iaaeinoaoiinoue ? iaei??th c oeaio?aeueieo i?iaeai aeooa?noaa i
ia?eiaoieiai?. Aiia aeeth/aia a Iiaeia?iaeio noaoenoe/io eeaneoieaoeith
oai?ia, o?aai i i?e/ei nia?oiinoi ye iaeei ?c iniiaieo neiae?ii?a noaio
ieiaeo ? iiaiia?iaeaeaiiai. I?ia?aeia ?ieue ieaoeaioe a i?ioeanao
oi?ioaaiiy ieiaeo iia’ycaia c ?? /eneaiieie ooieoe?yie, ye?
caaacia/othoue ca’ycie i?ae i?aai?ciii iaoa?? oa i?aaiaie ? oeaieiaie
ieiaeo, a oaeiae aaciina?aaeith o/anoue ieaoeaioe a iaoiaaiac?
oi?ioaaiiy aioo??oiueioo?iaii? iaoieia??, ui aecia/a?oueny
a?noio?c?ieia??th aeaiiai i?ia?ci?iiai i?aaio (?aoaoi?eiaa I.N.,
Iaeaeaiiaa I.A. oa ni?aaao., 1998). A eioa?aoo?i ? /eiaei aeaieo i?i
ii?oieiai/ii iniaeeainoi ieaoeaioe i?e oeoe?iaiio aeiaaaoi, aea aiie
aeineoue noia?a/eeai, ia aeaeieaii iniiaii caeiiiii?iinoi iaoieiai/ieo
i?ioeania, yei oa?aeoa?ecothoue ciiie ieaoeaioa?iiai aa?’??o i?e
oeoe?iaiio aeiaaaoi, ia a?aoiaaii nooiiiue aaaeeinoi, noai eiiiainaoei?,
iaoiae ?ic?iaeaeaiiy. Oaeei /eiii, ia?aia i?iaeaia ? aeooaeueiith oa
aeiaaa? iiaeaeueoeo aeine?aeaeaiue.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?eia ?iaioa “Ieaoeaioa?ia iaaeinoaoiinoue i?e oeoe?iaiio
aeiaaaoi oa ?? ei?aeoeiy” aeeiioaaeanue ca ieaiii iaoeiai? ?iaioe
eaoaae?e iaoieia?/ii? aiaoii?? Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ? 0197V007133 “Iaoiii?oieia?/i? aea?aaeaioe aino?i? ?
o?ii?/ii? iiii- ? iie?i?aaiii? iaaeinoaoiino? ??cii? ao?ieia??”.

Iaoa aeineiaeaeaiiy — ii?oiooieoeiiiaeuei? iniaeeaino? ieaoeaioe i?e
oeoe?iaiio aeiaaaoi oa oeyoe i?ioieaeoeee oa ei?aeoei? ieaoeaioa?ii?
iaaeinoaoiinoi i?e aeai?e iaoieia??.
.

Caaaeaiiy aeineiaeaeaiiy:

1. Aea/eoe oeueo?ano?oeoo?io oa oeueo?aainoioiii/io aoaeiao
ieaoeaioa?iiai aa?’??o i?e o?c?ieia?/i?e aaaioiinoi i iieiaao.

2. Aea/eoe oeueo?ano?oeoo?i? ci?ie ieaoeaioa?iiai aa?’??o i?e oeoe?iaiio
aeiaaaoi ?iciiai nooiaiy aaaeeinoi.

3. Anoaiiaeoe oeueo?aainoioiii/i? iniaeeaino? ieaoeaioa?iiai aa?’??o i?e
oeoe?iaiio aeiaaaoi ?iciiai nooiaiy aaaeeinoi.

4. Aeine?aeeoe ii?ooaiiy aoaeaaiaeiiai iai?io o aaa?oieo ae?iie, oai?eo
ia oeoe?iaee ae?aaao.

5. I?iaanoe e?euee?nia aecia/aiiy ?ioiiaeiaoe?i?a G,A,M oa
oee?eoethth/eo ?ioiieo eiiieaen?a o e?ia? aaa?oieo, oai?eo ia oeoe?iaee
ae?aaao.

6. I?iaiae?coaaoe aca?iica’ycie oeueo?ano?oeoo?ieo i
oeueo?aainoioiii/ieo ci?i ieaoeaioa?iiai aa?’??o o aaa?oieo ae?iie,
oai?eo ia oeoe?iaee ae?aaao ?c ii?ooaiiyi noaio aoaeaaiaeiiai iai?io oa
aoii?aeueiiai ?ioi?oaoo.

7. Aeyaeoe i?e/eie caaeaaei ieiaeo a caeaaeiinoi aiae
ii?oiooieoeiiiaeueieo ciii ieaoeaioa?iiai aa?’??o.

8. Ia iniia? anoaiiaeaieo ii?oiooieoeiiiaeueieo ciii ieaoeaioa?iiai
aa?’??o ii?aoethaaoe oeyoe i?io?eaeoeee oa ei?aeoe?? ieaoeaioa?ii?
iaaeinoaoiino? i?e oeoe?iaiio ae?aaao?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa io?eiaii a?aeiiino? i?i iniaeeaino? oeueo?ano?oeoo?e
ieaoeaioa?iiai aa?’??o a caeaaeiinoi aiae nooiaiy aaaeeinoi, noaio
eiiiainaoei?, iayaiinoi noaeeiieo oneeaaeiaiue oeoe?iaiai aeiaaaoo.
Aea/aii iniaeeaino? ci?i ieaoeaioa?iiai aa?’??o i?e oeoe?iaiio aeiaaaoi
a caeaaeiinoi aiae iaoiaeo ?ic?iaeaeaiiy oa noaio ieiaeo. Ie??i oiai,
aea/aii iniaeeaino? no?oeoo?ii-ooieoe?iiaeueiiai noaio ee?oei
ieaoeaioa?iiai aa?’??o ca aeiiiiiaith aeaeo?iiiiainoioiii/ieo iaoiaeia
(Na/E-AO?aca oa Ig2+-AO?aca).

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Ia iniia? io?eiaieo aeaieo i?i ii?oiooieoe?iiaeuei? iniaeeaino?
ieaoeaioe i?e oeoe?iaiio ae?aaao? ii?aoeueiaaii oa ai?iaaaeaeaii
iaoiaee/ii ?aeiiaiaeaoei? c i?ioieaeoeee i iiia?aaeaeaiiy aeooa?nueeeo
oa ia?eiaoaeueieo oneeaaeiaiue o aaaioieo c aeaiith iaoieia??th. Oea
aeicaieeoue nai?/anii oi?ioaaoe a aeiii/eo eiinoeueoaoeiyo a?oie ?eceeo
aaaioieo ca oeoe?iaei aeiaaaoii, i?iaiaeeoe i?io?eaeoeeo oneeaaeiaiue
aaa?oiino? oa oeoe?iaiai ae?aaaoo ia?aae ca/aooyi ? canoiniaoaaoe
eieoaaeueii caoiaee. Aena?oeaii i?e/eie, yei ni?eythoue ?icaeoeo
ieaoeaioa?ii? iaaeinoaoiinoi i?e oeoe?iaiio aeiaaaoi. Cai?iiiiiaaii
iaa?oioiaaiee iiaeoiae aei eieoaaiiy aaaioieo c oeoe?iaei aeiaaaoii, ui
aeicaieeoue caiiaiaoe ?icaeoeo noaeeiieo oneeaaeiaiue oeoe?iaiai
aeiaaaoo, ciaioeoe aeooa?nueeo iaoieiaith i ia?eiaoaeueii ao?aoe.

Ai?iaaaeaeaiiy ?acoeueoaoia o i?aeoeeo.

Iaoiaee/ii ?aeiiaiaeaoei? “Oeoe?iaee ae?aaao ? aaa?oi?noue” c
i?ioieaeoeee i eieoaaiiy aaaioieo, oai?eo ia oeoe?iaee aeiaaao
ai?iaaaeaeaii a i?aeoeeo e?eoaaeueieo onoaiia i?no Eueaiaa, Ee?aa,
Iaeane, ??aia, *a?i?aoe?a, Oa?niia. Io?eiaii naiaeioeoai ia
?aoeiiiaeicaoi?nueeo i?iiiceoeith ca N 1508 aiae 3.05.86 uiaei
oaeineiiaeaiiy iaoiaeee aeaeo?iiii? oeeoio?i??, ye? aeei?enoiaothoueny a
i?aeoeoe? aeaeo?iiii? i?e?ineii?? eaoaae?e iaoieia?/ii? aiaoii?? oa
OeIAeE Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. ?acoeueoaoe
aeena?oaoei? ai?iaaaeaeaii a iaa/aeueiee i?ioean eaoaae?
aiaeie?eiieiai?, aeooa?noaa i aiiaeieiai? iaaee/iiai oaeoeueoaoo oa
oaeoeueoaoo i?neyaeeieiiii? ina?oe Eueaianueeiai aea?aeaaiiai iaaee/iiai
oiiaa?neoaoo, eaoaae?e oa?ai?? c eo?nii aiaeie?eiieia?? iaaee/iiai
oaeoeueoaoo Oaeai?iaenueeiai aea?aeaaiiai oi?aa?neoaoo.

Iniiai? iieiaeaiiy, ye? aeiinyoueny ia caoeno:

1. I?e oeoe?iaiio ae?aaao? niinoa??aathoueny cia/i? ci?ie an?o oa??a
ieaoeaioa?iiai aa?’??o, ye? ciaoiaeyoueny a i?yi?e caeaaeiino? a?ae
nooiaiy aaaeeino? oa noaio eiiiainaoe?? iniiaiiai caoai?thaaiiy.

2. Ii?oiooieoe?iiaeuei? ci?ie ieaoeaioe i?e oeoe?iaiio ae?aaao?
ei?aeththoue c ii?ooaiiyi aoaeaaiaeiiai iai?io, ui i?ecaiaeeoue aei
i?eai?/aiiy ieenethaaeueieo i?ioean?a, a?iien?? ee?oei ? caeaaeeoue a?ae
nooiaiy aaaeeino? oa noaio eiiiainaoe?? iniiaiiai caoai?thaaiiy.

3. Ii?ooaiiy aoii?aeueiiai ?ioi?oaoo aieeaathoue ia
ii?oiooieoe?iiaeueiee noai ieaoeaioa?iiai aa?’??o ? ciaoiaeyoueny a
i?yi?e caeaaeiino? a?ae nooiaiy aaaeeino? oa noaio eiiiainaoe??
oeoe?iaiai ae?aaaoo.

4. Noai ieiaeo aaciina?aaeiuei caeaaeeoue a?ae noaae?? eiiiainaoe??
aoaeaaiaeiiai iai?io o iaoa?? oa aeeaeie ci?i ieaoeaioa?iiai aa?’??o.

5. No?eea eiiiainaoe?y oeoe?iaiai ae?aaaoo i?ioyaii aaa?oiino?, yea
aeinyaa?oueny ca aeiiiiiaith ?ioaineo?eiaaii? ?inoe?iioa?ai??, oa
?ic?iaeaeaiiy oeyoii eana?aaiai ?icoeio ni?eythoue cieaeaiith
ia?eiaoaeueii? nia?oiino?.

Ai?iaaoeiy ?iaioe.

?acoeueoaoe aeineiaeaeaiue iiaiaeiieaii oa iaaiai?aii ia 4-io oa 5-io
c’?caeao aiaeie?eiieia?a Oe?a?ie (Euea?a, 1987; ?aaii-O?aie?anuee,
1994), can?aeaiiyo Euea?anueei? o?e?? Anioe?aoe?? iaoieia?a Oe?a?ie
(Euea?a, 1997,1998), 1-o eo?nao i?neyaeeieiiiiai iaa/aiiy ?a?iiaenueei?
Ae?aaaoieia?/ii? Anioe?aoe?? (Euea?a, 1997), iaoeiai-i?aeoe/i?e
eiioa?aioe??, i?enay/ai?e 50-e?ooth EIAAe (Euea?a, 1997), can?aeaiiyo
Euea?anueeiai iaeaniiai aiaeie?eiieia?/iiai oiaa?enoaa (1992, 1997),
can?aeaiiyo a/aii? ?aaee iaae?ao?e/iiai oaeoeueoaoo Euea?anueeiai
aea?aeaaiiai iaaee/iiai ?inoeoooo (1992) oa a/aii? ?aaee iaaee/iiai
oaeoeueoaoo ?2 Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
(1998).

Ioaeieaoei?.

Ca iaoa?iaeaie aeineiaeaeaiue iioaeieiaaii 15 iaoeiaeo ?iaio, a yeeo
aenaioeaii iniiaiee ciino ?iaioe. Na?aae ieo — 4 noaoo? o oaoiaeo
aeo?iaeao, 4 — o ca??ieeao ? 7 oac o iaoa??aeao eiioa?aioe?e.

Ianya i no?oeoo?a aeena?oaoei?.

Aeena?oaoe?y neeaaea?oueny c anooio, iaeyaeo eioa?aoo?e, ?icae?eo
“Iaoa?iaee ? iaoiaee”, 4-o i?ae?icae?e?a aeanieo niinoa?aaeaiue,
iaaiai?aiiy ?acoeueoao?a, aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoeie, nieneo
aeei?enoaii? eioa?aoo?e, yeee iinoeoue 338 aeaea?ae aio/eciyieo i
ca?oaiaeieo aaoi?ia, aeiaeaoe?a. ?iaioa aeeeaaeaia ia 173 noi?iieao
iaoeiiieniiai oaenoo, i?noeoue 27 oaaeeoeue oa 54 ?enoiee.

Iniaenoee aianie caeiaoaa/a.

?iaioa ? iniaenoei caaa?oaiei aeine?aeaeaiiyi. Iaoiaeieia?/ia iniiaa
iaoeiai? ?iaioe a?aeiia?aea? iao? oa caaaeaiiyi. Aaoi? naiino?eii
i?iaaea iiooe e?oa?aoo?e ca caaeaiith oaiaoeeith, cae?enieea caa?? ?
aeine?aeaeaiiy iaoa??aeo, iaoaiaoe/io ia?iaeo iaea?aeaieo ?acoeueoao?a,
iienaea io?eiai? ?acoeueoaoe ? noi?ioethaaea aeniiaee. Caeiaoaa/
?ic?iaeea i ai?iaaaeeea iaoiaee/ii ?aeiiaiaeaoei? c i?io?eaeoeee
aeooa?nueeeo i ia?eiaoaeueieo oneeaaeiaiue, i?eioeeie eieoaaiiy
aaaioieo, oai?eo ia oeoe?iaee aeiaaao, o i?aeoeeo e?eoaaeueieo
caeeaae?a, iaa/aeueiee i?ioean iaaee/ieo aeueo iaa/aeueieo caeeaae?a.

IAOA??AE ? IAOIAeE AeINE?AeAEAIIss

Aeey ae??oaiiy iinoaaeaieo caaaeaiue i?iaaaeaii ianoaaeaiiy 60 aaaioieo,
oai?eo ia oeoe?iaee aeiaaao I oeio (iinoeiiicaeaaeiiai) ?icieo nooiai?a
aaaeeinoi. A?e oai?eo — a?ae 19 aei 37 ?ie?a. O?eaae?noue caoai?thaaiiy
— a?ae aia?oa aeyaeaiiai aei 20 ?ieia. I?iaaaeaii ianoaaeaiiy oai?eo i?e
iiaoi?ieo aaaioiinoyo.

I?e aiae?c? ?noi??e aaa?oiino? oa iieia?a a?aeeny aei oaaae aeai?
aeooa?nueei-a?iaeieia?/iiai aiaiiaco, ia?aa?ao aaa?oiino? oa iieia?a, ?o
iniaeeaino? oa oneeaaeiaiiy, ee?i?/ia ioe?iea aeno?aaai?oaeueii?
iaoieia??. Iieiae aaaioieo, oai?eo ia oeoe?iaee aeiaaao, a?aeaoaaeeny
i?e?iaeiei oeyoii, ?c canoinoaaiiyie iaeeo iia?aoeaieo ao?o/aiue,
eana?aaei ?icoeiii.

Oai?i io?eioaaee iaoiaaiaoe/ii iaa?oioiaaia eieoaaiiy ca aeiiiiiaith
iaoiaeo ?ioaineo?eiaaii? ?inoe?iioa?ai?? c aeinyaiaiiyi noaio
eiiiainaoe?? oeoe?iaiai aeiaaaoo. Ianoaaeaiiy i?iaiaeeeinue o ia?oi aeii
iaaeoiaeaeaiiy a noaoeiiia? i iiney caaa?oaiiy eo?no noaoeiiia?iiai
eieoaaiiy. Eiio?ieueio a?oio neeaee 8 i?aeoe/ii caei?iaeo aaaioieo
aeiiie oiai ae aieo.

?iciiae?e iaoa??aeo aeey aeine?aeaeaiue a caeaaeiino? a?ae nooiaiy
aaaeeino? oa iaoiaeo aeine?aeaeaiiy iiaeaiee a oaae. 1.

Oaaeeoey 1

Iaoa??ae aeey aeine?aeaeaiue

Iaoiaee aeine?aeaeaiiyIaoa??ae aeey aeine?aeaeaiueAeaeo?iiia
i?e?ineii?yAeaeo?iiia a?noio?i?yAecia/aiiy ?ioiiaeiaoe?i?a G,A,M oa
Oe?EAecia/aiiy

??aiy i??oaaoo

? eaeoaooEiio?ieue8688Aaa?oi?, oai?? ia OeAe

Eaaea nooi?iue5277Na?aaeiy nooi?iue831221Aaaeea nooi?iue2352024A n ue i
a i44164760

Aiiinieiee iaoa?iae ieaoeaioe aeineiaeaeoaaany ca aeiiiiiaith
aeaeo?iiii-iie?ineiii/iiai iaoiaeo. C iaoith aea/aiiy iaiiiieo
i?ioeania, yei a?aeaoaathoueny a ieaoeaioa?iiio aa?’??i, canoiniaaiee
aeaeo?iiii-ainoioiii/iee iaoiae aeineiaeaeaiiy c aecia/aiiyi o oeaieiao
Na/E-AO?ace oa Ig2+-AO?ace. Eiio?ieai aoee aiiioaoe ieaoeaioe i?aeoe/ii
caei?iaeo aaaioieo aeiiie.

Oeueo?ano?oeoo?ia aeine?aeaeaiiy ieaoeaioe (iiaa?oiaaiai oa?o
oeaio?aeueii? ae?eyiee iaoa?einueei? /anoeie) i?iaiaeeee ca
caaaeueiii?eeiyoith iaoiaeeeith o?aini?n?eiiai
aeaeo?iiii-i?e?ineii?/iiai aeine?aeaeaiiy (Glauert A.,1975) c
aeei?enoaiiyi aeaeo?iiieo iie?ineii?a OAAI — 100 E oa OAAI-100 E c
ae?ioaeueiith caeaoiinoth aiae 1500 aei 12400 ?acia.

Aeey aeaeo?iiii-ainoioiii/iiai aeyaeaiiy aeoeaiinoi Na/E-AO?ace
oiaoi/ee oeaieie ieaoeaioe i?aoienoaaee i?ioyaii 15 oaeeei 4% ?ic/eiii
oi?iaeueaeaaiaeo (c ia?aoi?io) ia 0,05 I eaeiaeeeaoiiio aooa?i
(?I=7,4) c aeiaeaaaiiyi 0,3 I naoa?ice (Aooaaeia ?.A., 1982). Iiney
i?iieaaiiy a eaeiaeeeaoiiio aooa?i c naoa?icith a?iioaoe ieaoeaioe
iieoaoaaee i?ioyaii 30 oaeeei i?e oaiia?aoo?i 37 °N ca iaoiaeii
I.A.Aooaaeiaa a iaoie iiaeeoieaoei? (?aoei?iiiceoeiy ?1508, 1986 ?.).

Noai iioiioaoo ioeiithaaee oeyoii eieueeiniiai aecia/aiiy
iioiiaeiaoeiiia G,A,I oa oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) a
e?ia?. Aiino iioiiaeiaoeiiia o ne?iaaooei e?iai aecia/aee iaoiaeii
?aaeiaeueii? iioiiaeeooci? ca Manchini (oeeo. ca *a?iioainoiaith A.A.,
1975); ai?no Oe?E c iieaeoey?iith ianith 6000 aeaeueoii iaoiaeii IAA a
e?ioeaa?e eiioeaio?aoe?? 3,5% (In?iia N.A. oa ni?aaaoi?e, 1983; Ianiiia
A.E., 1987).

Aecia/aee eiioeaio?aoe?th ii?oaaoo oa eaeoaoo a ne?iaaooei aaiicii?
e?iai ii Bergmeyer I.U. (1965).

Noaoenoe/ia ia?iaea iaea?aeaiiai oeeo?iaiai iaoa??aeo cae?enithaaeany
iaoiaeii aa??aoe?eii? noaoenoeee ca Nouethaeaioii-Oioa?ii ca aeiiiiiaith
IBM-noi?niiai eiii’thoa?a.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

1. Oeueo?ano?oeoo?ia ? oeueo?aoiii/ia aoaeiaa ieaoeaioa?iiai

aa?’??o i?e oiciieiai/iie aaaioiinoi oa iieiaao

Ieaoeaioa?iee aa?’?? neeaaea?oueny c oeaiei ieiaeiiai iioiaeaeaiiy
(o?ioiaeano, aacaeueia iaia?aia o?ioiaeanoa, niieo/iioeaieiia no?iia
ai?nei, aacaeueia iaia?aia aiaeioaeith eaiiey?ia i aiaeioaeiaeueii
eeioeie).

Aeaeo?iiiiiie?ineiii/ii aeineiaeaeaiiy iieacaee, ui o?ioiaeano, yeee
iie?eaa? ai?neie a ieaoeaioi ethaeeie, neeaaea?oueny c eeioei, yei
iathoue iaiaeiaeiao aeaeo?iiio uieueiinoue i oeueo?ano?oeoo?io
i?aaiicaoeith. A caeaaeiinoi aiae nooiaiy aeaeo?iiii? uieueiinoi
oeeoiieacie oa oeueo?ano?oeoo?ii? i?aaiicaoei? aeaeieythoueny o?e
iniiaii a?oie eeioei: eeioeie c aenieith aeaeo?iiiith uieueiinoth
oeeoiieacie (“oaiii” eeioeie aai neioeeoiio?ioiaeano), eeioeie iacia/ii?
aeaeo?iiii? uieueiinoi oeeoiieacie (eeioeie Eaia?aina, “naioei” eeioeie
aai oeeoio?ioiaeano), eeioeie, ye? iathoue i?iiiaeii oa?aeoa?enoeee
(“i?iiiaeii” eeioeie).

Aiaeicoth/e aeaii i?i eieaeicaoeith aeoeaiinoi Na/E-AO?ace oa ??
aca?iiaiaeiineie c oeueo?ano?oeoo?iith i?aaiicaoei?th aiioaeiaeueiiai
oa?o ieaoeaioe i?e oiciieiai/i?e aaaioiinoi oa iieiaao, ie aecia/eee,
ui Na/E- AO?aca, aeyaeaia ca aeiiiiiaith aeaeo?iiii? ainoioiii? o
aeaeyaei aeaeo?iiiiuieueieo a?aioe PaI?I4 aeiaiao?ii 5-60 ii,
eieaeico?oueny a ieaciieaii, ciaiioiie yaea?iie iaia?aii oa oia?eey?ieo
no?oeoo?ao yaea?oey. I?e i?iaaaeaiii eiio?ieueieo aeineiaeia AO?acia
aeoeaiinoue o ieaciieaii oa ciaiioiie iaia?aii yaea?ii? iaieiiee
i?aaenoaaeaia Na/E-AO?aciith aeoeaiinoth, a a yaea?oei — Ig2+- AO?aciith
aeoeaiinoth. ?iciiaeie aeoeaiinoi Na/E-AO?ace a aiioaei? ieaoeaioe
iineoue aaoa?iaaiiee oa?aeoa? i ciaoiaeeoueny a caeaaeiinoi aiae
aeaeo?iiii? uieueiinoi i oeueo?ano?oeoo?ii? i?aaiicaoei? eeioei.
Iaeneiaeueia Na/E-AO?acia aeoeaiinoue aeyaey?oueny a eeioeiao
neioeeoiio?ioiaeanoa. Ci ciaioaiiyi aeaeo?iiii? uieueiinoi eeioei
aiaeaoaa?oueny cieaeaiiy aeoeaiinoi Na/E-AO?ace, aae aei iiaii? ??
aiaenooiinoi a iaeneiaeueii aeaeo?iiiinaioeeo ee?oeiao oeeoio?ioiaeanoa.
A aiioaeiioeeoao Na/E-AO?acia aeoeaiinoue ?iciiaeieaia ia?iaiiii?ii.
Iaeaieueoa aeoeaiinoue aeyaey?oueny a iie?iai?neieao aiieaeueiiai
iiethno eeioei, o neeaaeeao aacaeueii? iaia?aie aiia ciaioo?oueny,
iaeiaioa aeoeaiinoue niinoa?iaa?oueny a eaoa?aeueiie ieaciieaii.

Aacaeueia iaia?aia iiae o?ioiaeanoii i no?iiith ai?nei ooai?aia c
iaoa?iaeo iiii?ii? aeaeo?iiii? uieueiinoi, aiiiaaiia, ae?iaiica?ienoa.
Iiae aacaeueiith iaia?aiith i eeioeiaie aiioaeiaeueiiai oa?o
i?inoaaeo?oueny naioeee i?inoi?. No?iia eiioeaaeo ai?nei iooea,
neeaaea?oueny c aonoi? nioee oiieeo eieaaaiiaeo aieieii. O
niieo/iioeaieiiie no?iii ai?nei cono?i/athoueny oia?iaeanoe, eeioeie
Eauaiei-Aioaaoa?a, ci?/anoi eeioeie, ia?eoeeoe, ieaciaoe/ii eeioeie.
Iiae niieo/iioeaieiiith no?iiith ai?nei i oa?ii aiaeioaeiioeeoia
eaiiey?a ?icoaoiaaia aacaeueia iaia?aia, yea yaey? niaith iioeiaeueii
noi?iiaaio no?oeoo?o.

Aiaeioaeiaeueii eeioeie iathoue iaiaeiaeiaee ?icii? i c’?aeiothoueny
iiae niaith ca aeiiiiiaith aeaniinii. ?o iiaa?oiy, caa?iaia a i?inaio
eaiiey?a, aeaaeea aai iinoeyie iie?eoa iiiaeeiieeie aenooiaie.
Aiaeioaeiaeueii eeioeie iinoyoue /eneaiii ?eainiie, iieiniie, aeaiaioe
aiaeiieaciaoe/ii? nioee (a?aioey?ii? oa aa?aioey?ii?), eiiieaen
Aieueaeaei oa ?icii ca ?icii?ii iioioiiae?i?. O aaaaoueio
aiaeioaeiaeueieo eeioeiao a aiaeiieacii aecia/a?oueny aaeeea eieueeinoue
oieaiaioia. ssae?a aiaeioaeiioeeoia aaeee?. O?iiaoei iaeiie/o?oueny
ia?aaaaeii aiey ia?eoa?i? yae?a, iinoeyie iiaeieyth/enue ia ie?aii
a?oie. Iae/anoioa cono?i/athoueny aiaeioaeiioeeoe na?aaeiuei?
aeaeo?iiii? uieueiinoi c iioeiaeueii ?icaeiaieie oeueo?ano?oeoo?aie.
Aiaeioaeiaeueii eeioeie eaiiey?ia eiioaeoothoue c ia?eoeeoaie.

Eaiiey?e a oiiaao oiciieiai/ii? aaaioiinoi oa iieiaia iathoue oe?ieee
i?inaio. Ieacia e?iai i?aaenoaaeaia ae?iaiica?ienoith
aeaeo?iiiiuieueiith oacith i na?aaeiaeuai iecueei? aeaeo?iiii?
uieueiinoi. Eeioeie e?iai (a?eo?ioeeoe, eaeeioeeoe) — na?aaeiuei?
aeaeo?iiii? uieueiinoi, i?noyoue iioeiaeueii ?icaeiai? no?oeoo?e.

2. Oeueo?ano?oeoo?ia oa oeueo?aoeeoioiii/ia aoaeiaa ieaoeaioa?iiai

aa?’??o i?e oeoe?iaiio aeiaaaoi

Iaie i?iaaaeaii aeine?aeaeaiiy ieaoeaio ii?iae?eue, oai?eo ia oeoe?iaee
ae?aaao ??ciiai nooiaiy aaaeeino?. I?e oeueiio i?inoaaeaia ia?aeaeue
i?ae nooiaiai aaaeeino?, noaae??th eiiiainaoe??, o?eaae?noth ae?aaaoo ?
aeeaeiith ci?i a oeueo?ano?oeoo?i?e i?aai?caoe?? ieaoeaioa?iiai aa?’??o.

Aeyaeaii ci?ie ieaoeaioa?iiai aa?’??o, ye? caeaaeaoue a?ae nooiaiy
aaaeeino? oeoe?iaiai ae?aaaoo. I?e eaaeiio nooiai?, a noaae??
noaeiiiainaoe??, ee?oeie neioeeo?io?ioiaeanoa ciaoiaeyoueny ia
aacaeuei?e iaia?ai? o aeaeyae? iaeiioa?iaiai ee?oeiiiai ieanoo, aea i?e
oeueiio niinoa??aa?oueny ciaioaiiy ieiu? neioeeo?aeueiiai ai?oae?th, ia
iiaa?oi? yeiai ciaoiaeyoueny i?e?iai?neiee ??cii? aenioe.
Oeeoiieaciaoe/iee iao?een neioeeo?io?ioiaeanoa ia? na?aaeith aeaeo?iiio
u?euei?noue, o iueiio ciaoiaeyoueny ?eainiie, iie?niie, aaeeea
e?euee?noue iaeeo ? na?aaeiuei? aaee/eie aeaaeeino?iieo aaeoieae ?
i?e?ioeeoicieo aaceeoe, iii??ia e?euee?noue i?oioiiae??e c? caa?aaeaieie
e?enoaie ? aeaeo?iiiiu?eueiei iao?eenii, cono??/athoueny oaeiae
iiiaeeiie? e?ciniie.

O oai?eo c na?aaei?i nooiaiai aaaeeino? oeoe?iaiai ae?aaaoo, a noaae??
noaeiiiainaoe??, neioeeo?io?ioiaeano ia? ia??aiii??io oiaueio ?
aeaeo?iiio u?euei?noue. Ee?oeie neioeeo?th a?eueo aeaeo?iiiiu?euei? ?
aaeoie?ciaai?. Ia ai?eaeuei?e iiaa?oi? ciaioaia e?euee?noue i?e?iai?nei.
O oeeoiieaci? neioeeo?th ciaioaia e?euee?noue i?oioiiae??e oa ieiua
eiiieaeno Aieueaeae?, aiaeii/an ca?eueoaia e?euee?noue e?cinii. ssae?a
neioeeo?io?ioiaeanoa ca?eueoai?, iathoue iai?aaeeueio oi?io. Aei
yaea?ii? iaieiiee i?eeyaa? eiiaeainiaaiee yaea?iee o?iiaoei. Ee?oeie
oeeoio?ioiaeanoa aeaeo?iiiina?oe?, a oeeoiieaci? ciaoiaeyoueny
iiiaeeiie? e?ciniie ? i?oioiiae??? iaaeueii? oi?ie.

I?e aaaeeiio nooiai?, a noaae?? noaeiiiainaoe?? oeoe?iaiai ae?aaaoo,
niinoa??aa?oueny ??cia aeaeo?iiia u?euei?noue ee?oei
neioeeo?io?ioiaeanoa. Ee?oeie neioeeo?th iathoue cia/ii i?aeaeuaio
aeaeo?iiio u?euei?noue — “oaii?” ee?oeie. Oeeoiieacia aaeoie?ciaaia,
e?euee?noue i?aaiae cia/ii ciaioaia. I?oioiiae???, ?eainiie, iie?niie
i?aeoe/ii cieeathoue. Niinoa??aa?oueny aaeoie?caoe?y eiiieaeno
Aieueaeae?, aiaeiieaciaoe/ii? n?oee. ssae?a ee?oei neioeeo?th
iai?aaeeueii? oi?ie c eiiaeainiaaiei o?iiaoeiii, yeee i?eeyaa? aei
yaea?ii? iaieiiee. Ee?oeie o?ioiaeanoa noathoue aeaeo?iiiina?oeeie —
“na?oe?” ee?oeie. A oeeoiieaci? oeeo ee?oei niinoa??aa?oueny aaeeea
e?euee?noue aaeoie?ciaaieo i?aaiae. I?e?ii?iioeeoicia aeoeai?noue cia/ii
ciaioaia. ssae?a ca?eueoai?, c iaeei ai?noii o?iiaoeio.

Aeaeiiiainaoe?y oeoe?iaiai ae?aaaoo i?ecaiaeeoue aei aaoa?iaaiiino?
neioeeo?io?ioiaeanoa. Ee?oeie neioeeo?th iathoue cia/io aeaeo?iiio
u?euei?noue a ii??aiyii? c ee?oeiaie oeeoio?ioiaeanoa. Niinoa?iaa?oueny
caieueoaiiy oia?eii?aeo, a oaeiae ciie eiceno c o/anoth eaeeioeeoia.
Oiaueia neioeeoith eiioeaaeo ai?nei cia/ii caieueoo?oueny. Ia
iiaa?oii neioeeoith aeyaeythoueny iiiaeeiiei, /anoi aeaoi?iiaaii, aeoaea
ei?ioei oa aeano?oeoeaii ciiiaii iie?iai?neiee. Ia aaaaoueio aeieyieao
ai?nei aiie acaaaei aiaenooii, ui naiae/eoue i?i cia/ia ciaioaiiy
iaiiiii? iiaa?oii iiae iaoi?’th oa ieiaeii i noi?iaiaeaeo?oueny
ii?ooaiiyi iaoaaieicio i iiai?oaiiyi o?ainii?oo ?a/iaei. A
iiaeai?neieiaiio i?inoi?i a cia/ieo eieueeinoyo aeyaeythoueny yae?a i
oeeoiieacia eeioei neioeeoiio?ioiaeanoa, yei ?oeiothoueny, a oaeiae
oia?eio.

I?e iieiaao i?e?iaeiei oeyoii ? aioaiaoaeuei?e caaeaae? ieiaeo
niinoa??aathoueny cia/i? ci?ie neioeeo?io?ioiaeanoa. Ee?oeie neioeeo?th
aeaeo?iiiiu?euei? oa aaeoie?ciaai?. A?aaionuee? aaeoie? eiioaeoothoue c
yae?aie. ssaea?iee o?iiaoei eiiaeainiaaiee. O oeeoiieaci? cia/ii
ciaioaia e?euee?noue i?aaiae. I?aeoe/ii an? i?aaiaee ciaoiaeyoueny a
noaae?? aaeoie?caoe??. Ia ai?eaeuei?e iiaa?oi? iii?oii ciaioaia
e?euee?noue i?e?iai?nei, ye? ciaoiaeyoueny a noai? aeano?oeoe??.
Aiaeii/an ee?oeie o?ioiaeanoa aeaeo?iiiii?ina?oeai?, c aaeeeeie yae?aie.
A oeeoiieaci? iaeaea an? i?aaiaee aaeoie?ciaai?, c’yaeythoueny aaeoie?
aaeeeeo ?ici???a.

Iaie aeyaeaii, ui i?e ?ic?iaeaeaii? oeyoii eana?aaiai ?icoeio ee?oeie
neioeeo?io?ioiaeanoa caa?aaeai? oa ooieoe?iiaeueii aeoeai?. Ia
ai?eaeuei?e iiaa?oi? neioeeo?th aeia?a caa?aaeai? i?e?iai?neiee, ye?
iathoue iaeiaeiao aeiaaeeio. Oeeoiieaciaoe/iee iao?een
neioeeo?io?ioiaeanoa na?aaeiuei? aeaeo?iiii? u?eueiino?. A oeeoiieaci?
i?noeoueny aaeeea e?euee?noue caa?aaeaieo ?eainii, iie?nii. A?aioee
aiaeiieaciaoe/ii? n?oee ? eiiieaen Aieueaeae? caa?aaeai?. I?oioiiae???
na?aaeiuei? aeaeo?iiii? u?eueiino? c /anoeiai c?oeiiaaieie e?enoaie.
ssae?a ie?oaei? oi?ie, c aeia?a caa?aaeaiei a oeaio?? oa eiiaeainiaaiei
ii ia?eoa??? ea??ieaie o?iiaoeiii.

Aiae?coth/e aeai? i?i eieae?caoe?th aeoeaiino? Na/E-AO?ace a
ieaoeaioa?iiio aa?’??? i?e oeoe?iaiio ae?aaao? o?aaa a?aecia/eoe ca’ycie
c? nooiaiai aaaeeino? oa noaiii eiiiainaoe?? iniiaiiai caoai?thaaiiy:
aeoeai?noue AO?ace ciaioo?oueny c ia?inoaiiyi nooiaiy aaaeeino? oa
aeaeiiiainaoe??. A aiioaeiioeeoao Na/E-AO?acia aeoeaiinoue ?iciiaeieaia
ia?iaiiii?ii. Iaeaieueoa aeoeaiinoue aeyaey?oueny a iie?iai?neieao
aiieaeueiiai iiethno eeioei, o neeaaeeao aacaeueii? iaia?aie aiia
ciaioo?oueny, iaeiaioa aeoeaiinoue niinoa?iaa?oueny a eaoa?aeueiie
ieaciieaii.

Cia/ii iioiauo?oueny aacaeueia iaia?aia o?ioiaeanoa oa aacaeueia
iaia?aia eaiiey?ia, ui iaoiaiiiiii/ii aeey oeoe?iaiai aeiaaaoo.
Aeaeo?iiia uieueiinoue ?? iaiaeii?iaeia, a aeayeeo i?noeyo aiia noa?
aaaaoioa?iaith, i?ae oa?aie cono??/a?oueny ee?oeiiee aeao?eo oa aaeeea
eieueeinoue aeeth/aiue. Iaea?eueoa iioiauaiiy aacaeueii? iaia?aie
niinoa??aa?oueny i?e aeaeiiiainaoe?? oeoe?iaiai ae?aaaoo. I?e aeecueeiio
?icoaooaaii? e?iaiiiniiai eai?ey?a a?ey o?ioiaeanoa iaeaea? aacaeuei?
iaia?aie c’?aeiothoueny ? ooai?ththoue oa?, yeee iioiauo?oueny a
aeae?eueea ?ac?a ii??aiyii c ii?iith. Noai aacaeueii? iaia?aie
caeaaeeoue a?ae ?ioaineaiino? iai?iieo i?ioean?a a aiaeioae?aeueieo
ee?oeiao e?iaiiinieo eai?ey??a. I?e oeoe?iaiio ae?aaao? ii?ooo?oueny
iai?i ?a/iaei, ui aieeaa? ia iaoaaie?ci, ii?oieia?/iee ?
ooieoe?iiaeueiee noai aiaeioae?ioeeo?a, ye? ii/eiathoue neioacoaaoe
ae?eiciai?iiae?eaie a a?eueo?e e?eueeino?, aiane?aeie /iai
iineeth?oueny iaa?ye ia?eeai?ey?iiai i?inoi?o, ui, a naith /a?ao,
i?ecaiaeeoue aei ii?ooaiiy o?io?ee.

Oa? niieo/iioeaieiii? no?iie cia/ii oe?oee, aieueoi? aeaeo?iiii?
uieueiinoi, iinoeoue aaeeeo eieueeinoue eieaaaiiaeo aieieii, ye?
caeiathoue aaeeeo ieiuo ? ?icoaoiaai? oaioe/ii. Niieo/ia oeaieia
iaa?yea?, a i?e iaeiie/o?oueny o?a?eii?ae, ca?eueoo?oueny e?euee?noue
o?a?iaeano?a, oo/ieo oa ieaciaoe/ieo ee?oei, ye? aaciina?aaeiuei
eiioaeoothoue c aacaeueiith iaia?aiith.

Aeaeiiiainaoe?y oeoe?iaiai ae?aaaoo noi?iaiaeaeo?oueny aeeno?io?/ieie
ci?iaie a aiaeioae?aeueieo ee?oeiao e?iaiiinieo eai?ey??a. C?inoa?
iaa?ye aiaeioae?aeueieo ee?oei, i?ina?o eai?ey??a aeaaeae? caoaeo?oueny.
*ano?oa cono??/athoueny eai?ey?e c iiai?noth ia?ae?eoei i?ina?oii.
Oeeoiieacia ca?aei?ea ia aioo??oiueiee?oeii? i?aaiaee, cieaeaia
i?e?ii?iioeeoicia aeoeai?noue. I?oioiiae??? iaaooathoue, ?o e?enoe
?oeiothoueny. Aeaye? i?oioiiae??? ia?aoai?ththoueny o aaeoie?.
Ca?eueoo?oueny e?euee?noue i??e?iiiiae?aieo no?oeoo?. Ia ethi?iaeuei?e
iiaa?oi? aiaeioae?ioeeo?a aeiaaea? ieoeiiiae?aiee aeaeo?iiiiu?eueiee
o?a?ei. Ie?ai? aiaeioae?ioeeoe aeaneaaiiaai?, iineeth?oueny
i?e?ieeaciaoic i?e?iai?nei ? oeeoiieaciaoe/ieo aenooi?a. Aiane?aeie
aeano?oeoeaieo ci?i aiaeioae?aeueiee oa? aeoii/o?oueny ? oaiano?o?oueny,
i?aeaeuo?oueny i?iieei?noue eai?ey??a, iineeth?oueny aeo?ae ieacie oa
ee?oeiiiai aeao?eoo a noaaiaeioae?aeueiee i?ino??, ui aieeaa? ia
aeano?oeoeai? i?ioeane a niieo/i?e oeaiei?. A i?ina?o? e?iaiiinieo
eai?ey??a i?noeoueny ee?oeiiee aeao?eo, o?a?ei, i?e?ieeaciaoici?
/anoeiee. Ieacia e?ia? noa? a?eueo ini?io?eueiith. I?ae
aiaeioae?ioeeoaie ooai?ththoueny u?eeie, /a?ac ye? a aacaeueio iaia?aio
i?ioiaeeoue ieacia e?ia?, ee?oeiiee aeao?eo, oeaiee c?oeiiaaieo ee?oei.
Niinoa??aa?oueny cia/ia aaeoie?caoe?y aiaeioae?ioeeo?a, iniaeeai ?o
ia?eioeeaa?iiai i?inoi?o, ui ii?oieia?/ii a?aeia?aaeo? ii?ooaiiy
yaea?ii-oeeoiieaciaoe/ieo a?aeiinei ? na?ae/eoue i?i cieaeaiiy
a?eeiai-neioaoe/ieo i?ioean?a. A aeayeeo eai?ey?ao a?aeaoaa?oueny iiaia
?oeiaoe?y aiaeioae?aeueieo ee?oei.

I?e oeoe?iaiio ae?aaao? cia/ieo ci?i caciathoue ia?eoeeoe. A oeeo
ee?oeiao i?ioiaeyoue aeeno?io?/i? ci?ie: oeeoiieacia i?ina?oeth?oueny,
i?oioiiae??? iaaooathoue, i?aaiaee aaeoie?cothoueny. Ia?aeaeueii
niinoa??aathoueny oeueo?aa?noio?i?/i? ci?ie: a i?oioiiae??yo
i?eai?/o?oueny Ig2+- AO?acia aeoeai?noue, i?iaeoeo a?noio?i?/ii?
?aaeoe?? eieae?co?oueny ia e?enoao i?oioiiae??e o aeaeyae? ie?aieo
aeaeo?iiiiu?eueieo a?aioe. I?e aeaeiiiainaoe?? oeoe?iaiai ae?aaaoo a
i?oioiiae??yo i?ioiaeyoue aeeno?io?/i? ci?ie c ooai?aiiyi
i??e?iiiiae?aieo no?oeoo?. I?inoaaeo?oueny caeaaei?noue aeano?oeoeaieo
ci?i a ia?eoeeoao a?ae noaae?? aeaeiiiainaoe?? oeoe?iaiai ae?aaaoo. I?e
aaaeeiio nooiai? oeoe?iaiai ae?aaaoo, a noaae?? aeaeiiiainaoe??,
ia?eoeeoe iaaooathoue, iao?een ?o i?ina?oeth?oueny, an? ee?oeii?
i?aaiaee ?iciaaeathoueny. Ia?eoeeo ?oeio?oueny ? eiai caeeoee
iaeiie/othoueny i?ae oa?aie aacaeueii? iaia?aie o aeaeyae? aeao?eoii?
iane. Iaa?ye aacaeueii? iaia?aie i?ecaiaeeoue aei ca?eueoaiiy a?aenoai?
i?ae aiaeioae?ioeeoaie oa ia?eoeeoaie ? ii?ooaiiy ?o aca?iia?aeiinei.
I?e eiiiainiaaiiio ia?aa?ao oeoe?iaiai ae?aaaoo, iaa?oue i?e
na?aaeiueiio ? aaaeeiio nooiaiyo, ia?eoeeoe iathoue iaeaea iaci?iaio
no?oeoo?o ? eieae?cothoueny iiaeeco aiaeioae?ioeeo?a.

Aaaeeeao ?ieue o ii?ooaii? ooieoe?? ieaoeaioa?iiai aa?’??o a?ae?a?a?
ci?ia ?aieia?/ieo aeanoeainoae e?ia?. Oe? ci?ie, a ia?oo /a?ao,
niinoa??aathoueny c aieo a?eo?ioeeo?a. A?eo?ioeeoe aeoeaii ?aaaothoue ia
ii?ooaiee, aiane?aeie ?inoe?iiai? iaaeinoaoiino?, iaoaaie?ci oeaiei. O
i?ina?o? e?iaiiinieo eai?ey??a niinoa??aa?oueny aaeaac?y a?eo?ioeeo?a
aei aiaeioae?ioeeo?a, ooai?ththoueny a?eo?ioeeoa?i? aa?aaaoe.
A?eo?ioeeoe iie?ii?oi? ca nai?ie ?ici??aie ? aeaeo?iiiith u?euei?noth, c
??ciiiai?oieie ae?inoaie ? i?e?ieeaciaoicii. I?ia?anoaaiiy nooiaiy
aaaeeino? oeoe?iaiai ae?aaaoo noi?iaiaeaeo?oueny ca?eueoaiiyi
a?eo?ioeeo?a o ?ici??ao, ?o aa?aaaoe??th oa cieaeaiiyi ini?io?eueiino?.
*a?ac ca?eueoaiiy ia’?io, ci?ie oi?ie ? ii?ooaiiy aeaoi?iaoe?eii?
caeaoiino? niia?eueith?oueny ? iia??oo?oueny ?oo a?eo?ioeeo?a ii
eai?ey?ao, a ?ieiee niinoa??aa?oueny iaoo?aoe?y noaeei. Aiane?aeie ci?ie
o?ceei-o?i?/ieo aeanoeainoae a?eo?ioeeoa?ii? iaia?aie ii?ooo?oueny ia
o?eueee iniioe/ia, aea e iaoai?/ia no?ee?noue a?eo?ioeeo?a. Oaeei /eiii,
e?euee?noue ii?iaeueii ooieoe?iioth/eo e?iaiiinieo eai?ey??a cia/ii
ciaioo?oueny, ui i?ecaiaeeoue aei a?iien??.

O e?iaiiinieo eai?ey?ao c’yaey?oueny aaeeea e?euee?noue aeaoi?iiaaieo,
aaiie?ciaaieo a?eo?ioeeo?a c iiieaeaiith Na/E-AO?aciith aeoeai?noth.
A?eo?ioeeoe iathoue aeaeyae iaia?aiiiiae?aieo no?oeoo?, oae caai? “o?i?”
a?eo?ioeeo?a. Iaia?aia oaeeo a?eo?ioeeo?a ?iciooaia, ao?a/a?
eiioo?i?noue, ia ?o iiaa?oi? c’yaey?oueny ini?io?eueia ?a/iaeia, yea ii
ciai?oiueiio aeaeyaeo ia a?ae??ciy?oueny a?ae a?eo?ioeeoa?ii?.
Aeaeo?iiia u?euei?noue ieacie e?ia? i?aeaeuo?oueny. A i?ina?o? eai?ey?a
ca?eueoo?oueny e?euee?noue iaaaeeeeo a?aioey?ieo ian i?iaeoeoo AO?acii?
?aaeoe?? c? c?oeiiaaieo a?eo?ioeeo?a.

I?e aaaeeiio nooiai? oeoe?iaiai ae?aaaoo, a noaae?? aeaeiiiainaoe??,
ci?ie aioo??oiuei-noaeeiii? aa?aaaoe?? a?eo?ioeeo?a i?aaenoaaeai?
iaeyne?aa?oa. I?ina?o eai?ey?a caoaeaiee, /anoi iae?oa?iaaiee ci?iaieie
ca oeiii “iiiaoieo noiaa/ee?a” a?eo?ioeeoaie, niinoa??aa?oueny
“neaaeae-neiae?ii”, ae?aiaaeac a?eo?ioeeo?a o ia?eeai?ey?iee i?ino??.
Cia/ii c?inoa? e?euee?noue aaiie?ciaaieo a?eo?ioeeo?a (a?eo?ioeeoa?i?
“o?i?”), ieacia e?ia? i?aeaeuaii? ini?io?eueiino?. Iaeiie/aiiy
i?iaeoeo?a ?iciaaeo ee?oei, aaiie?ciaaieo a?eo?ioeeo?a,
ciai?oiueia?eo?ioeeoa?iiai aaiiaeia?io, o?a?eio a ieaci? e?ia? ni?ey?
ci?i? ooieoe?iiaeueii? aeoeaiino? o?iiaioeeo?a ? iiya? a i?ina?o?
eai?ey??a a?eo?ioeeoa?ii-o?iiaioeeoa?ieo aa?aaao?a.

A?ia?aa?aaaoe?y /ano?oa niinoa??aa?oueny a i?noeyo ae?aaeaii?
aeano?oeoe?? aiaeioae?aeueieo ee?oei ? iaieaiiy aacaeueii? iaia?aie.
A?aecia/a?oueny aaeaac?y o?iiaioeeo?a aei aiaeioae?th e?iaiiinieo
eai?ey??a. O?iiaioeeoe ci?iththoueny, ii?ooo?oueny oe?e?ni?noue ?o
oeeoiieaciaoe/ii? iaia?aie, ai?no oeeo ee?oei aeoiaeeoue a ieacio e?ia?.
A aeayeeo eaiiey?ao c’yaeythoueny iie?io?iiae, aei ?o neeaaeo
aoiaeyoue a?eo?ioeeoe, eaeeioeeoe, o?iiaioeeoe, oia?ei. *anoi
cono?i/athoueny eaiiey?e, i?inaio yeeo iiaiinoth cae?eoee i?e?io?iiaaie.

Oaeei /eiii, ii?ooaiiy iaoaaie?cio i?e aeaeiiiainaoe?? oeoe?iaiai
ae?aaaoo ni?ey? ?icaeoeo ae?aaaoe/ii? i?e?iaia?iiao?? a ieaoeaio? c
ii?oiooieoe?iiaeueieie ci?iaie a?eo?ioeeo?a ? o?iiaioeeo?a, ui
i?ecaiaeeoue aei ii?ooaiiy i?e?ioee?eoeyoe?? ieaoeaioe ? a?iien??
ieiaeo. Noaae?y ae?aaaoe/ii? i?e?iaia?iiao?? caeaaeeoue a?ae nooiaiy
aaaeeino? oeoe?iaiai ae?aaaoo ?, iniaeeai, a?ae noaio eiiiainaoe??
iniiaiiai caoai?thaaiiy.

3. Noai aoii?aeueiiai iioiioaoo o aaaioieo aeiiie,

oai?eo ia oeoe?iaee aeiaaao

Iai?oaeai?noue aoii?aeueiiai ?ioi?oaoo ioe?ithaaee a oiiaao
o?c?ieia?/ii? ii?ie, a oaeiae i?e oeoe?iaiio aeiaaao? o ae?oaie
iieiaeii aaaioiinoi. Anoaiiaeaii, ui i?e an?o nooiaiyo aaaeeino?
oeoe?iaiai aeiaaaoo niinoa??aa?oueny cia/ia iiaeaeuaiiy eiioeaio?aoei?
Ig G, A, M oa ia?inoaiiy Oe?E. Iae?noioi?oa iiaeaeuaiiy ?iaiy Ig G
a?aecia/a?oueny i?e na?aaeiueiio (22,84 ± 3,07 a/e, ?<0,01) i aaaeeiio (29,16 ± 2,79 a/e, ?<0,001) nooiaiyo aaaeeinoi oeoe?iaiai aeiaaaoo. Cia/ia ca?eueoaiiy eiioeaio?aoei? Ig I o ne?iaaooei e?iai aeyaey?oueny i?e eaaeiio (1,94±0,18 a/e, ? <0,01) oa aaaeeiio nooiaiyo (2,48±0,17 a/e, p<0,05). ??aaiue Oe?E noaiiaea: i?e eaaeiio nooiai? — 218,27±4,40 oi.iae. (?<0,001), i?e na?aaeiueiio — 332,88±10,45 oi.iae. (?<0,001), i?e aaaeeiio — 453,77±15,37 oi.iae. (?<0,001). I?iaaaeaiiy ?ioaineo?eiaaii? ?inoe?iioa?ai?? noi?iaiaeaeo?oueny cieaeaiiyi aiinoo Ig G, A, M oa Oe?E. Cie?aia, i?e eaaeiio nooiaii ?iaaiue Ig G ciaioeany aei 8,94±0,71 a/e (?<0,01), i?e na?aaeiueiio — 10,74 ±0,36 a/e, (?<0,01), a i?e aaaeeiio — 9,90±0,56 a/e (?<0,001). Oe? iieacieee i?aeoe/ii iaaeeceeeny aei ?iaiy Ig G o i?aeoe/ii caei?iaeo aeiiie. O aaa?oieo c aaaeeei nooiaiai aeinoiai?ii cieaeo?oueny ?iaaiue Ig A (1,61±0,07 a/e, ?<0,01) oa Ig I (1,61±0,11 a/e, ?<0,001). A oie aea /an, ??aaiue Oe?E aeinoia??ii ciaioo?oueny i?e an?o nooiaiyo aaaeeino? oeoe?iaiai ae?aaaoo, a?aeiia?aeii: i?e eaaeiio nooiai? — 175,87±3,26 (?<0,001); i?e na?aaeiueiio — 224,04±17,56 (?<0,001); i?e aaaeeiio — 249,36±17,04 (?<0,001). Oaeei /eiii, i?e aaaioiinoi ia oiii oeoe?iaiai aeiaaaoo ciinoa?iaa?oueny cia/ia ciiia iieacieeia aoii?aeueiiai iioiioaoo, iia’ycaia c? nooiaiai aaaeeinoi caoai?thaaiiy. I?iaaaeaiiy ?ioaineo?eiaaii? ?inoe?iioa?aii? c aeinyaiaiiyi eiiiainaoei? oeoe?iaiai ae?aaaoo noi?iaiaeaeo?oueny ii?iaeicaoei?th ?iaiy iioiiaeiaoeiiia oa Oe?E o e?iai. I?aeaeuaiiy ??aiy ?ioiiaeiaoe?i?a oa Oe?E, ye? aeyaeythoue iioeiaeaeoth/o ae?th ia noaeeiio no?ieo, ni?e/eith? i?enei?aiee ?icaeoie i?e?iaia?iiao?? ieaoeaioe. Iiney i?iaaaeaiiy iaoiaaiaoe/iiai eieoaaiiy, nea?iaaiiai ia eiiiainaoeith oeoe?iaiai aeiaaaoo aecia/a?oueny ii?iaeicaoeiy iieacieeia aoii?aeueiiai iioiioaoo, ui ni?ey? iie?auaiith ooieoei? ieaoeaioe. 4. Ii?ooaiiy aoaeaaiaeiiai iaiiio o aaaioieo aeiiie, oai?eo ia oeoe?iaee aeiaaao I?e aaa?oiino? ia oii? oeoe?iaiai aeiaaaoo aeyaeaii ca?eueoaiiy eiioeaio?aoei? ii?oaaoo oa eaeoaoo a ne?iaaooe? e?ia?. Iaeaieueoa iiaeaeuaiiy ai?noo ii?oaaoo niinoa??aa?oueny i?e aaaeeiio (0,180±0,014 iIieue/e, ?<0,001) oa na?aaeiueiio nooiaii aaaeeinoi (0,132 ± 0,024 iIieue/e, ? < 0,05) a ii?iaiyiii c eiio?ieueiith a?oiith, aea ?iaaiue ii?oaaoo noaiiaeoue 0,065 ± 0,005 iIieue/e. Eiioeaio?aoe?y eaeoaoo iiaeaeuo?oueny aaea i?e eaaeiio (2,63±0,36 iIieue/e, ?<0,05) i na?aaeiueiio nooiaiyo aaaeeinoi (2,47±0,14 iIieue/e, ?<0,001), a iaeaeu? iieacieee eaeoaoo niinoa?iaathoueny i?e aaaeeiio ia?aa?ao oeoe?iaiai aeiaaaoo (3,12±0,21 iIieue/e, ?<0,001) a ii?iaiyiii c eiio?ieai (1,38±0,08 iIieue/e). I?iaaaeaiiy ?ioaineo?eiaaii? ?inoe?iioa?ai?? ni?eyei cia/iiio ciaioaiith eiioeaio?aoe?? i??oaaoo i?e eaae?e oi?i? oeoe?iaiai ae?aaaoo (0,077±0,006 iIieue/e, ?<0,05), ui iaeaea iaaeeaea?oueny aei iieacieeia o?c?ieia?/ii? ii?ie; i?e na?aaeiueiio nooiaii ai?no i??oaaoo iii?oii cieaeo?oueny (0,106±0,014 iIieue/e, ?<0,001), a i?e aaaee?e oi?i? ?iaaiue ii?oaaoo caeeoa?oueny aenieei (0,133±0,09 iIieue/e, ?<0,001), aea cia/ii cieaeo?oueny a ii?iaiyiii c iieacieeaie aei eieoaaiiy (0,180±0,014 iIieue/e, ?<0,01). I?iaaaeaiiy ?ioaineo?eiaaii? ?inoe?iioa?ai?? noi?iaiaeaeo?oueny iiceoeaiith aeeiai?eith ai?noo eaeoaoo a ne?iaaooe? e?ia? aaa?oieo ae?iie, oai?eo ia oeoe?iaee ae?aaao, cie?aia, iaeaieueoa aeeiaiiea cieaeaiiy eiioeaio?aoe?? eaeoaoo niinoa?iaa?oueny i?e eaae?e oi?ii (1,84±0,27 iIieue/e, ?>0,05); i?e
na?aaeiueiio nooiaii ?iaaiue eaeoaoo iiney eieoaaiiy noaiiaea
(1,99±0,09 iIieue/e, ?<0,01) a i?e aaaee?e oi?ii — 3,12±0,21 iIieue/e (?<0,001), i?ioa a ii?iaiyiii c eiio?ieueiith a?oiith eiai ??aaiue caeeoa?oueny aenieei. Oaeei /eiii, iaie aeyaeaii, ui o aaaioieo aeiiie, oai?eo ia oeoe?iaee aeiaaao, niinoa?iaa?oueny cia/ia iiaeaeuaiiy ?iaiy ii?oaaoo oa eaeoaoo a ne?iaaooei aaiicii? e?iai, yea iia’ycaia ci nooiaiai aaaeeinoi caoai?thaaiiy. I?iaaaeaiiy ?ioaineo?eiaaii? ?inoe?iioa?ai?? c aeinyaiaiiyi eiiiainaoei? aoaeaaiaeiiai iaiiio ni?ey? cieaeaiith aiinoo ii?oaaoo oa eaeoaoo a ne?iaaooei e?iai aaaioieo aeiiie, oai?eo ia oeoe?iaee aeiaaao. I?e eaae?e oi?ii oeoe?iaiai ae?aaaoo oe? iieacieee iaeaea iiaa?oathoueny aei ii?ie, a i?e na?aaeiueiio i aaaeeiio nooiaii caoai?thaaiiy niinoa??aa?oueny iiceoeaia aeeiai?ea iieacieeia eiioeaio?aoe?? i??oaaoo ? eaeoaoo, iaeiae aei oiciieiai/ii? ii?ie inoaii? ia iiaa?oathoueny. Io?eiai? iaie ?acoeueoaoe, i/aaeaeii, iiaeia iiynieoe iaaeinoaoiinoth iinoeiio a i?aaiicii i?e oeoe?iaiio ae?aaao?, ui i?ecaiaeeoue aei cieaeaiiy ieenethaaeueieo i?ioeania. E?ii oiai, i?e iinoeiiiaie iaaeinoaoiinoi ca aieeao aae?aiiei?oeeio?iiiiai ai?iiio iineeth?oueny ooai?aiiy ii?oaaoo oa eaeoaoo, aaeueio?oueny aeaea?aieneethaaiiy i??oaaoo (Bradley R.J., Brudenell J.M., Nicolaides K.H., 1991). Oaeei /eiii, aeinyaiaiiy noaio eiiiainaoe?? oeoe?iaiai ae?aaaoo noi?iaiaeaeo?oueny ciaioaiiyi a?iien?? oeaiei. AENIIAEE 1. I?e oeoe?iaiio ae?aaao? niinoa??aathoueny cia/i? ci?ie an?o oa??a ieaoeaioa?iiai aa?’??o (o?ioiaeanoa, aacaeueii? iaia?aie o?ioiaeanoa oa e?iaiiinieo eai?ey??a, niieo/ii? oeaieie, aiaeioae?ioeeo?a e?iaiiinieo eai?ey??a), ye? iia’ycai? c? nooiaiai aaaeeino?, noaae??th eiiiainaoe?? iniiaiiai caoai?thaaiiy. 2. Ciinoa??aa?oueny aeaci?aai?caoe?y oeueo?ano?oeoo?ii? aoaeiae o?ioiaeanoa ieaoeaioe: cia/ia aaoa?iaaii?noue oa aaeoie?caoe?y ee?oei, ii?ooaiiy yaea?ii-oeeoiieaciaoe/iiai ni?aa?aeiioaiiy c eiiaeainaoe??th o?iiaoeio, ciaioaiiy oa ?oeiaoe?y i?oioiiae??e, ?eainii, iie?nii, eiiieaeno Aieueaeae?, ca?eueoaiiy e?cinii oa o?a?eii?aeo. 3. Iaoiaiiiii?/iith iciaeith oeoe?iaiai ae?aaaoo ? cia/ia iioiauaiiy aacaeueii? iaia?aie o?ioiaeanoa oa e?iaiiinieo eai?ey??a ieaoeaioe. Aacaeueia iaia?aia iioiauo?oueny ia??aiii??ii, /anoi niinoa??aa?oueny ?? ?icoa?oaaiiy. Niieo/ia oeaieia iaa?yea?, a i?e iaeiie/o?oueny o?a?eii?ae, ca?eueoo?oueny e?euee?noue o?a?iaeano?a, oo/ieo oa ieaciaoe/ieo ee?oei, ye? aaciina?aaeiuei eiioaeoothoue c aacaeueiith iaia?aiith. 4. Aiaeioae?ioeeoe e?iaiiinieo eai?ey??a ieaoeaioe aeano?oeoeaii ci?iththoueny: ia?inoa? iaa?ye ee?oei, niinoa??aa?oueny cia/ia aaeoie?caoe?y oeeoiieacie, ?oeiaoe?y i?aaiae c? ciaioaiiyi ?o e?eueeino?. Ii?ooaiiy aaiii?e?ioee?eoeyoe?? i?iyaeythoueny o aeaeyae? aaiie?co, neaaeaeo a?eo?ioeeo?a, iiyaith a?eo?ioeeoa?ii-o?iiaioeeoa?ieo aa?aaao?a, ci?oaieo i?e?io?iia?a. 5. Ooieoe?iiaeueii-no?oeoo?i? ci?ie ieaoeaioa?iiai aa?’??o i?e oeoe?iaiio ae?aaao? ciaoiaeyoueny a i?yiiio aca?iica’yceo c? noaiii eiiiainaoe?? iniiaiiai caoai?thaaiiy. No?eea eiiiainaoe?y oeoe?iaiai ae?aaaoo i?e aaa?oiino? niia?eueith? ?icaeoie ae?aaaoe/ieo ci?i ieaoeaioa?iiai aa?’??o. I?e noaeiiiainaoe?? oa aeaeiiiainaoe?? iniiaiiai caoai?thaaiiy ii?oiooieoe?iiaeuei? ci?ie ieaoeaioa?iiai aa?’??o oaeaeei i?ia?anothoue. 6. Cia/ia i?aeaeuaiiy iai?oaeaiino? aoii?aeueiiai ?ioi?oaoo, yea i?iyaey?oueny ca?eueoaiiyi ??aiy ?ioiiaeiaoe?i?a G, A, I oa Oe?E, ni?ey? ?icaeoeo ae?aaaoe/ii? aia?iiao?? ieaoeaioe. ?ioaineo?eiaaia ?inoe?iioa?ai?y c aeinyaiaiiyi eiiiainaoe?? aoaeaaiaeiiai iai?io noi?iaiaeaeo?oueny ii?iae?caoe??th iieaciee?a aoii?aeueiiai ?ioi?oaoo o aaa?oieo ae?iie, oai?eo ia oeoe?iaee ae?aaao, ui, iiina?aaeeiaaii, na?ae/eoue i?i iie?auaiiy ooieoe?? ieaoeaioe. 7. Ii?ooaiiy aoaeaaiaeiiai iai?io, ye? i?ecaiaeyoue aei cieaeaiiy ieenethaaeueieo i?ioean?a oa a?iien??, iia’ycai? c? nooiaiai aaaeeino? oeoe?iaiai ae?aaaoo. Ia oiii i?iaaaeaiiy ?ioaineo?eiaaii? ?inoe?iioa?ai?? c eiiiainaoei?th aoaeaaiaeiiai iaiiio niinoa?iaa?oueny cieaeaiiy aiinoo i??oaaoo oa eaeoaoo a ne?iaaooei e?iai aaaioieo aeiiie, oai?eo ia oeoe?iaee aeiaaao, aea aei oiciieiai/ii? ii?ie oe? iieacieee ia iiaa?oathoueny, ui na?ae/eoue i?i caa?aaeaiiy a?iien?? oeaiei. 8. Iaoiii?oieia?/iee noai ieaoeaioa?iiai aa?’??o i?e oeoe?iaiio ae?aaao? cia/iith i??ith iia’ycaiee c iaoiaeii ?ic?iaeaeaiiy. I?e iieiaao oeyoii eana?aaiai ?icoeio aeano?oeoeai? ci?ie ieaoeaioe ae?aaeai? iaio ?noioii, i?ae i?e iieiaao i?e?iaeiei oeyoii. 9. Eiiiainaoe?y iaoaaie?/ieo ii?ooaiue i?e oeoe?iaiio ae?aaao? i?ioyaii aaa?oiino? niia?eueith? ?icaeoie iaoiii?oieia?/ieo ci?i o ieaoeaio?, ciaioo? ?iia??i?noue aeieeiaiiy ii?ooaiue aioaiaoaeueiiai ?icaeoeo oa ni?ey? cieaeaiith ia?eiaoaeueii? nia?oiino? i?e oe?e iaoieia??. I?AEOE*I? ?AEIIAIAeAOe?? 1. AE?ieai, oai?ei ia oeoe?iaee ae?aaao, iaiao?aeii caa/anii ieaioaaoe aaa?oi?noue ? aeinyaaoe noaio eiiiainaoe?? iniiaiiai caoai?thaaiiy ia?aae caie?aeiaiiyi. 2. Aeey oieeiaiiy oneeaaeiaiue aaa?oiino?, iieia?a, i?neyiieiaiaiai oa iaiiaoaeueiiai ia??iae?a iaiao?aeii ?aoaeueia ianoaaeaiiy o ae?ii/eo eiinoeueoaoe?yo aaa?oieo uiaei iayaiino? o ieo ii?ooaiue aoaeaaiaeiiai iai?io, iniaeeai a?oi ?eceeo c oeoe?iaiai ae?aaaoo, aeoeaii aeyaeyoe oai?eo c aanoaoe?eiei ae?aaaoii. 3. C iaoith i?io?eaeoeee oneeaaeiaiue oeoe?iaiai ae?aaaoo oa aaa?oiino? iaiao?aeii iino?eii eiio?iethaaoe ? i?aeo?eioaaoe noai eiiiainaoe?? o oai?eo ia?aae ? i?ae /an aaa?oiino? ca aeiiiiiaith iaoiaeo ?ioaineo?eiaaii? oa?ai??. 4. Aeey ciaioaiiy ia?eiaoaeueii? iaoieia?? oa nia?oiino? iaiao?aeia i?aeo?eiea noaio iiaii? eiiiainaoe?? oeoe?iaiai ae?aaaoo ia?aae ? i?ioyaii aaa?oiino? oa ?aeiiaiaeiaaii ?ic?iaeaeaiiy oeyoii eana?aaiai ?icoeio. 5. Oeueo?ano?oeoo?ia oa oeueo?aa?noio?i?/ia oa?aeoa?enoeea ieaoeaioa?iiai aa?’??o iiaea aooe aeei?enoaia ye ?ao?iniaeoeaiee e?eoa??e aaeaeaaoiino? iniiaieo ooieoe?e ieaoeaioe, nooiaiy eiiiainaoe?? iaoaaie?/ieo ii?ooaiue i?e oeoe?iaiio ae?aaao?, aeeaeie oa o?eaaeino? a?iien?? a ia??iae aaa?oiino?. CIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Naoiiiaa I.A., Eiaaeeoei A.?. Eieae?caoeey aeoeaiino? Na+,K+-AOOace oa oeueo?ano?oeoo?a ai?oae?th ieaoeaioe ae?iie, oai?eo oeoe?iaei ae?aaaoii // Iaae?ao??y, aeooa?noai ? a?iaeieia?y.- 1989.- ?1.- N. 54-55. 2. Oiiaoaanueeee I.ss., Oiiaoaanueea ss.?, Ieaoaiia ?.A., Na?a??iei I.I., Aaee/ei A.ss., Iaea? ?.Ae., Naoa?iaa ?.A., E?ania I.N., Ei?aeiaa I.?., Naoiiiaa I.A., Oa?ainiae/ I.ss., *a?iiaa I.A., E?ooye I.I., O?oiiae/ E.A. Ia?aiao?e niaaeeiai? noeeueiino? ianaeaiiy aei oeoe?iaiai ae?aaaoo // Aeooaeuei? i?iaeaie iaaeeoeeie, a?ieia??, aaoa?eia??? ? n?euenueeiai ainiiaea?noaa. Ei. iaoe. noaoae.- Euea?a, 1996.- N.62-63. 3. Naoiiiaa I.A. Oeueo?ano?oeoo?a ieaoeaioa?iiai aa?’??o i?e oeoe?iaiio ae?aaao? // Acta Medica Leopoliensia.- 1997.- ?3-4.- N.47-52. 4. Naoiiiaa I.A. Aieea ?ioaineo?eiaaii? ?inoe?iioa?ai?? ia iieacieee aoii?aeueiiai ?ioi?oaoo i?e oeoe?iaiio ae?aaao? ia oe? aaa?oiino? // E?ee.- 1998.-?4.- N.7-9. 5. Naoiiiaa I.A., Eiaaeeoei A.E., Ieaoaiia A.A. Yeaeo?iiiiaenoioeie/aneia auyaeaiea Na+,K+-AOOacu a ieaoeaioa i?e naoa?iii aeeaaaoa // I?iaeaiu iaoieiaee a yenia?aiaioa e eeeieea: O?oaeu EIAeIAIE / Iiae ?aae. O.A.Ieoeiie.- Eueaia, 1985.- O.7.- N.182-183. 6. Eiaaeeoei A.E., Ieaoaiia A.A., Naoiiiaa I.A., Eooa?oe E.E. Iiaeeoeeaoeey n?aaeu E.A.Aooaaeiaa (1982) ii auyaeaieth Na+,K+-AOOacu ia oeueo?ano?oeoo?iii o?iaia // I?iaeaiu iaoieiaee a yenia?eiaioa e eeeieea: O?oaeu EIAeIAIE / Iiae ?aae. O.A.Ieoeiie.- Eueaia, 1985.- O.7.- N.183. 7. Ieaoaiia A.A., Aiaeia E.O., Naoiiiaa I.A. Ii?oiooieoeeiiaeueiua eciaiaiey o?iiaioeeoia o aieueiuo naoa?iui aeeaaaoii n aiaeiiaoeyie // I?iaeaiu iaoieiaee a yenia?eiaioa e eeeieea: Na.iao/.o?. / Iiae ?aae. O.A.Ieoeiie.- Eueaia, 1987.- O.7.- N.119. 8. Naoiiiaa I.A. Ii?oiooieoeeiiaeueiua eciaiaiey y?eo?ioeeoia a ieaoeaioa o aieueiuo naoa?iui aeeaaaoii // I?iaeaiu iaoieiaee a yenia?eiaioa e eeeieea: Na.iao/.o?. / Iiae ?aae. O.A.Ieoeiie.- Eueaia, 1987.- O.9.- N.121-122. 9. Ieaoaiia A.A., Oiiaoaaneee ss.E., Na?aeaiei A.A., Ao?eooeeay I.A. Eiioiiua eiiieaenu a iaoaiecia ?acaeoey aeeaaaoe/aneie aiaeiiaoee // Ananithci. neiiiceoi ”Aaneoeeou, aiaeiiaoee, aiaeiaeenieacee”.- Eueaia, 1983.- N.130-132. 10. Oiiaoaaneee ss.E., Ao?eooeeay I.A., Ieaoaiia A.A. Oeueo?ano?oeoo?iua eciaiaiey aaiiiee?ioee?eoeyoi?iiai ?onea ieaoeaiou i?e naoa?iii aeeaaaoa // Ananithci. iao/i. eiio. “Aeooaeueiua aii?inu ia?ooaiee aaiiaeeiaieee e ?aaoeyoeee a eeeieea e yenia?eiaioa”.- Iineaa, 1984.- N.163-164. 11. Naoiiiaa I.A. Niaea?aeaiea ie?iaeiia?aaeiie e iiei/iie eeneio a e?iae o aa?aiaiiuo aeaiuei aieueiuo naoa?iui aeeaaaoii // ?anioa. iao/ii-i?aeo. eiio. iieiaeuo o/aiuo iaaeeeia ”Aeooaeueiua aii?inu nia?aiaiiie yiaeie?eiieiaee e eiioiieiaee”.- Oa?ueeia, 1986.- N.41. 12. Naoiiiaa I.A. Eciaiaiey oeueo?ano?oeoo?u e?iaaiiniuo eaieey?ia ieaoeaiou i?e naoa?iii aeeaaaoa // 4 nuacae yiaeie?eiieiaia ONN? “Cia?aiaiiua i?iaeaiu yenia?eiaioaeueiie e eeeie/aneie yiaeie?eiieiaee”.- Eeaa, 1987.- N.339. 13. Naoiiiaa I.A. Oeueo?ano?oeoo?a ai?iae?aeueiiai oa?o ieaoeaioe ae?iie, oai?eo ia oeoe?iaee ae?aaao // 5 c’?cae aiaeie?eiieia?a Oe?a?ie ”No/ani? i?iaeaie aenia?eiaioaeueii? oa ee?i?/ii? aiaeie?eiieia??”.- Ee?a, 1994.- N. 142-143. 14. Ieaoaiia A.A., Aia?ia ?.O., Naoiiiaa I.A. No?oeoo?ii-ooieoe?iiaeueiee noai o?iiaioeeo?a ? aiaeioae?aeueieo ee?oei e?iaiiinieo eai?ey??a i?e ae?aaaoe/i?e aia?iiao?? // 5 c’?cae aiaeie?eiieia?a Oe?a?ie ”No/ani? i?iaeaie aenia?eiaioaeueii? oa ee?ie/ii? aiaeie?eiieia??”.- Ee?a, 1994.- N. 133-134. 15. Naoiiiaa I.A. Noai aoii?aeueiiai ?ioi?oaoo o aaa?oieo ae?iie, oai?eo ia oeoe?iaee ae?aaao // Iaoe.-i?aeo. eiio., i?enay/. 50-??//th EIAAe ”Aeooaeuei? i?iaeaie ee?i?/ii? aiaeie?eiieia??”.- Euea?a, 1997.- N.60-61. Naoiiiaa I.A. Ieaoeaioa?ia iaaeinoaoiinoue i?e oeoe?iaiio aeiaaaoi oa oeyoe ?? ei?aeoei?. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.03.02 - iaoieiai/ia aiaoiiiy. Eueaianueeee aea?aeaaiee iaaee/iee oiiaa?neoao ?i. Aeaieea Aaeeoeueeiai, Eueaia, 1998. Aeena?oaoe?y i?enay/aia aea/aiith oeueo?ano?oeoo?ieo oa oeueo?aa?noio?i?/ieo iniaeeainoae ieaoeaioa?iiai aa?’??o, aeine?aeaeaiith ii?ooaiue aoaeaaiaeiiai iai?io oa aoii?aeueiiai ?ioi?oaoo i?e oeoe?iaiio ae?aaao? a caeaaeiino? a?ae nooiaiy aaaeeino?, noaae?? eiiiainaoe??, iaoiaeo ?ic?iaeaeaiiy oa noaio ieiaea. Iieacaii, ui i?e ii?ooaiiyo aoaeaaiaeiiai iai?io, coiiaeaieo i?eai?/aiiyi ieenethaaeueieo i?ioean?a oa a?iien??th, niinoa??aa?oueny i?aeaeuaiiy iai?oaeaiino? aoii?aeueiiai ?ioi?oaoo, yea ni?ey? ?icaeoeo ae?aaaoe/ii? aia?iiao??. No?oeoo?ii-ooieoe?iiaeuei? ci?ie ieaoeaioe, ye? aeieeathoue i?e oeoe?iaiio ae?aaao?, aaciina?aaeiuei iia’ycai? c? noaiii eiai eiiiainaoe??. Anoaiiaeaii, ui noai eiiiainaoe?? aoaeaaiaeiiai iai?io, yeee aeinyaa?oueny ca aeiiiiiaith ?ioaineo?eiaaii? ?inoe?iioa?ai??, ii?iae?co? iieacieee aoii?aeueiiai ?ioi?oaoo oa niia?eueith? ?icaeoie ae?aaaoe/ieo ci?i ieaoeaioe. Eeth/ia? neiaa: oeoe?iaee ae?aaao, aaa?oi?noue, ieaoeaioa?iee aa?’??, oeueo?ano?oeoo?a, aoaeaaiaeiee iai?i, aoii?aeueiee ?ioi?oao. Naoiiiaa I.A. Ieaoeaioa?iay iaaeinoaoi/iinoue i?e naoa?iii aeeaaaoa e iooe aa ei??aeoeee. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.02 - iaoieiae/aneay aiaoiiey. Eueaianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. Aeaieea Aaeeoeeiai, Eueaia, 1998. Aeenna?oaoeey iinayuaia eco/aieth oeueo?ano?oeoo?iuo e oeueo?aaenoioeie/aneeo iniaaiiinoae ieaoeaioa?iiai aa?uea?a, enneaaeiaaieth ia?ooaiee oaeaaiaeiiai iaiaia e aoii?aeueiiai eiioieoaoa i?e naoa?iii aeeaaaoa a caaeneiinoe io noaiaie oyaeanoe, noaaeee eiiiainaoeee, iaoiaea ?iaei?ac?aoaiey e ninoiyiey ieiaea. Iieacaii, /oi i?e ia?ooaieyo oaeaaiaeiiai iaiaia, iaoneiaeaiiuo oaiaoaieai ieeneeoaeueiuo i?ioeannia e aeiieneae, iaaethaeaaony iiauoaiea iai?yaeaiiinoe aoii?aeueiiai eiioieoaoa, eioi?ia niinianoaoao ?acaeoeth aeeaaaoe/aneie aiaeiiaoee. No?oeoo?ii-ooieoeeiiaeueiua eciaiaiey ieaoeaiou, eioi?ua iiyaeythony i?e naoa?iii aeeaaaoa, iaiin?aaenoaaiii naycaiu ni noaaeeae aai eiiiainaoeee. Onoaiiaeaii, /oi ninoiyiea eiiiainaoeee oaeaaiaeiiai iaiaia, eioi?ia aeinoeaaaony n iiiiuueth eioaneoeoee?iaaiiie einoeeiioa?aiee, ii?iaeecoao iieacaoaee aoii?aeueiiai eiioieoaoa e caiaaeeyao ?acaeoea aeeaaaoe/aneeo eciaiaiee ieaoeaiou. Eeth/aaua neiaa: naoa?iue aeeaaao, aa?aiaiiinoue, ieaoeaioa?iue aa?uea?, oeueo?ano?oeoo?a, oaeaaiaeiee iaiai, aoii?aeueiee eiioieoao. Safonova O.V. Placental insufficiency in diabetes mellitus and ways of it correction. - Manuscript. Thesis for a candidate’s degree by speciality 14.03.02 - patological anatomy. Lviv D.Halytskiy State Medical Univesity, Lviv, 1998. The dissertation is devoted to study ultrastructural and ultrahystochemical characterization of the placental barrier, disorders of glucose metabolism, proofs of hymoral immunity on diabetic pregnancy of different hards degree, compensation, methods of delivery, fetus state. We established, violation of glucose metabolism, which carries to decrease of oxidational processes and hypoxia, high tensity of hymoral immunity, what conducts to development of diabetic angiopathias. Considerable structural and functional diabetic chages of placenta, which have direct dependence from stage compensation of main desease were revealed. There is established a compensation status of glucose metabolism, which is reaching thanks to intensificational insulin therapy conduct to normal proofs of hymoral immunity and retards development of placental diabetic changes. Key words: diabetes mellitus, pregnancy, placental barrier, ultrastructure, glucose metabolism, hymoral immunity. I?aeienaii aei ae?oeo 16.11.98. Oi?iao 60o84 1/16 Ia’?i 1 ae?oe a?e. Caiiaeaiiy ? 177. Iaeeaae 100. Aaceiooiaii. Aeaeaaie/i-iie?a?ao?/iee oeaio? “Ia?iaeia caei?ia’y”, i.Euea?a, aoe. Iaea?nueea, 69 a

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