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Патогенетичне обгрунтування застосування мікроелементів у поєднанні з вітаміном Е для профілактики ранньої анемії недоношених дітей: Автореф. дис… к

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?INOEOOO IAAe?AO???, AEOOA?NOAA OA A?IAEIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

NAE?AOA? EANss AI?EN?AIA

OAeE: 616.155.194-039-053.32-092-084-085.356/.358

IAOIAAIAOE*IA IAA?OIOOAAIIss CANOINOAAIIss

I?E?IAEAIAIO?A O II?AeIAII? C A?OAI?III A AeEss

I?IO?EAEOEEE ?AIIUeI? AIAI?? IAAeIIIOAIEO Ae?OAE

14.01.10 – Iaae?ao??y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? oaeoeueoaonueei? oa oieoaeueii? iaae?ao???
Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea
Aaeeoeueeiai IIC Oe?a?ie.

Iaoeiaee ea??aiee:aeieoi? iaaee/ieo iaoe, i?ioani?
OEA*AIEI Na?oeaia Eocuei?aia, Euea?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai IIC Oe?a?ie, caa?aeoaa/ eaoaae?e
oaeoeueoaonueei? oa oieoaeueii? iaae?ao???.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?, caneoaeaiee ae?y/ iaoee oa oaoi?ee
Oe?a?ie IIAEUe*AIEI Ethaeieea ?aai?aia, ?inoeooo iaae?ao???, aeooa?noaa
oa a?iaeieia?? AII Oe?a?ie, caa?aeoaa/ a?aeae?eaiiy aeeoa?aioe?eii?
ae?aaiinoeee, e?eoaaiiy oa i?io?eaeoeee caoai?thaaiue aioo??oi?o i?aai?a
o ae?oae;

aeieoi? iaaee/ieo iaoe OOIUeEI ?eecaaaoa ?aaai?aia, Ee?anueea iaaee/ia
aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie, caa?aeoaa/
eaoaae?e iaiiaoieia??.

I?ia?aeia onoaiiaa:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey IIC Oe?a?ie
(i.Ee?a), eaoaae?a iaae?ao??? N 2.

Caoeno a?aeaoaeaoueny ” 30 ” /a?aiy 1999 ?. i 10 aiae. ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae26.553.01 ?c caoenoo
aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaoe ca
niaoe?aeueiinoyie “Iaae?ao??y”, “Aeooa?noai oa a?iaeieia?y” i?e
?inoeooo? iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050,
i.Ee?a, aoe. Iaio?eueneiai,8).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i.Ee?a, aoe.
Iaio?eueneiai,8).

Aaoi?aoa?ao ?ic?neaiee ” 21 ” o?aaiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee EAAOI?IA E.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?iaioa i?enay/aia aeooaeuei?e i?iaeai? no/anii?
iaaee/ii? iaoee ? i?aeoeee, ine?eueee ?aiiy aiai?caoe?y iaaeiiioaieo
ae?oae ? aeineoue iioe?aiei noaiii, ui iiaea aecia/aoe iniaeeaino?
ia?aa?ao ia eeoa i?ciueiai iaiiaoaeueiiai, aea e a?oaeiiai ia??iaeo.
Iiaeyaee ia oeth i?iaeaio ci?ithaaeenue i?ioyaii inoaii?o 30 ?ie?a.
Iacaaaeath/e ia cia/io e?euee?noue iaoeiaeo aeine?aeaeaiue, ui aoee
i?iaaaeai? o oeueiio iai?yieo, ieoaiiy iaoiaaiaco ?aiiuei? aiai??
iaaeiiioaieo ae?oae, i?aeoiaee aei ?? ioe?iee, iiaeeeainoae i?io?eaeoeee
oa e?eoaaiiy ia iiaeooue aaaaeaoeny aeinoaoiuei aea/aieie, a ?nioth/?
?aeiiaiaeaoe?? – caaaeueiii?eeiyoeie.

?ic?iaea eiiieaenii? nenoaie i?io?eaeoeee ?aiiuei? aiai?? iaaeiiioaieo
ae?oae ia? aaaeeeaa cia/aiiy aeey i?aeaeuaiiy aoaeoeaiino?
aeoiaeaeoaaiiy ia?aae/anii ia?iaeaeaieo iaiiaeyo.

Iaaeiiioai? ae?oe iathoue i?aeaeuaiee ?ecee ?icaeoeo aeao?oeeoo
i?e?iaeaiaio?a [Aggett P., 1994, Tsang R.C., 1993]. Ia nueiaiaei?
aeao?oeeo i?e?iaeaiaio?a a i?aai?ci? ? caaaeueiith i?iaeaiith a
iaaeeoeei? oa i?eaa?oa? aei naaa oaaao ana a?eueoi? e?eueeino?
aeine?aeiee?a o ca’yceo c oe?ieei oa aoaeoeaiei canoinoaaiiyi a?ioee?a
aeey caiia?aaiiy ianoa/? ?o ? oa?ai?? ii?ooaiiai iaoaaie?cio
i?e?iaeaiaio?a i?e iaoieia?/ieo noaiao i?aai?cio [Taylor A., 1996,
Nordberg G., 1996]. Aiae?c no/anieo aeaieo e?oa?aoo?e iieacaa, ui
cae?ci, i?aeue ? eiaaeueo, a?ae?a?athoue aeeeth/ii aaaeeeao ?ieue o
i?ioeanao e?iaioai?aiiy [Aaoeui A.I., 1991, Olivares M., 1996].
E?euee?nia aecia/aiiy ai?noo oeeo i?e?iaeaiaio?a o e?ia? i?aaenoaaey?
niaith aaeeeee ?ioa?an i?e aea/aii? o?c?ieia?? nenoaie e?ia? ? aiai?/ieo
noai?a. Oiio aa?oa oaaae aecia/aiiy ai?noo aeacaieo aeua i?e?iaeaiaio?a
o e?ia? iaaeiiioaieo ae?oae a ia??iae ?o ?aiiuei? aiai?caoe??.

A oiiaao a?iien??, ii?ooaiue iai?iieo i?ioean?a, ye? aeieeathoue i?e
?aii?e aiai?? iaaeiiioaieo ae?oae, ? iaieio/ei iaaaoeaiee aieea ia noai
oi?iaieo aeaiaio?a e?ia? c ii?ooaiiyi aioo??oiueiee?oeiiiai iaoaaie?cio,
ci?iaie oeueo?ano?oeoo?e. A e?oa?aoo?? cono??/athoueny iia?aeiieaiiy,
i?enay/ai? aea/aiith oeueo?ano?oeoo?e ee?oei e?ia? i?e a?iio?iiieo
aiai?yo [Einaaa I.E., 1989, Eiceiaoe A.E., 1984]. Ioae?eaoe?e i?i
aiaeia?/i? aeine?aeaeaiiy o iaaeiiioaieo ae?oae c ?aiiueith aiai??th ie
ia ciaeoee.

Ia aeeaey/enue ia aaeeeo e?euee?noue aeine?aeaeaiue noiniaii ?aiiuei?
aiai?? iaaeiiioaieo, ia i?iaiae?ciaaiei caeeoa?oueny aieea ?yaeo aioa-
oa ?io?aiaoaeueieo oaeoi??a ia noai /a?aiii? e?ia? iaaeiiioaieo ae?oae ?
iiaeaeueoee ?icaeoie ?aiiuei? aiai??. Inoaoi/ii ia aeyniaii, yeo ?ieue
a?ae?a?athoue i?e?iaeaiaioe, ui aa?ooue o/anoue o i?ioeanao
e?iaioai?aiiy, o ?icaeoeo ?aiiuei? aiai?? a ia?aae/anii ia?iaeaeaieo
iaiiaeyo. I?aeoe/ii ia ?ic?iaeai? aoaeoeai? iaoiaee iaa?oioiaaii?
i?io?eaeoeee ?aiiuei? aiai?? iaaeiiioaieo. Oaeei /eiii, ia?aia i?iaeaia
? aeooaeueiith oa aeiaaa? iiaeaeueoeo aeine?aeaeaiue.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeeiiaiiy ?iaioe
iia’ycaii c ae??oaiiyi aaaeeeaeo ieoaiue ? i?iaeai iaoeiai? i?ia?aie
“Ia?eiaoaeueia ioi?iia ieiaea ? iiaiia?iaeaeaiiai a no/anieo oiiaao
Oe?a?ie” a iai?yieo aeyaeaiiy oa ioe?iee oaeoi??a ?eceeo, iiooeo oeyo?a
i?io?eaeoeee caoai?thaaiue, ai?iaaaeaeaiiy no/anieo iaaee/ieo
oaoiieia?e. Aeaia aeena?oaoe?eia ?iaioa iia’ycaia c iaoeiaith oaiaoeeith
eaoaae?e oaeoeueoaonueei? oa oieoaeueii? iaae?ao??? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo “Aecia/aiiy i?iaiinoe/iiai cia/aiiy
aioo??oiueioo?iaii? ? iinoiaoaeueii? a?iien?? o oi?ioaaii? niiaoe/ii? ?
iaa?ieia?/ii? iaoieia??. ?ic?iaea iaoiae?a ?aiiuei? ae?aaiinoeee,
e?eoaaiiy, i?io?eaeoeee oa ?aaa?e?oaoe??”, N aea?ae?a?no?aoe?? –
01980000871.

Iaoa aeine?aeaeaiiy – ?ic?iaeoe eiiieaenio nenoaio i?io?eaeoeee ?aiiuei?
aiai?? iaaeiiioaieo ia i?aenoaa? aea/aiiy iniaeeainoae ?? ia?aa?ao,
aecia/aiiy ai?noo i?e?iaeaiaio?a o e?ia? a ia?aae/anii ia?iaeaeaieo
iaiiaeyo oa aeine?aeaeaiiy oeueo?ano?oeoo?e a?eo?ioeeo?a.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe iniaeeaino? aeeiai?ee iieaciee?a /a?aiii? e?ia? a ia?aae/anii
ia?iaeaeaieo iaiiaeyo ia?oeo aeaio i?nyoe?a aeeooy.

2. Anoaiiaeoe /anoioo ?aiiuei? aiai?? iaaeiiioaieo, oaeoi?e ?eceeo ??
?icaeoeo oa iniaeeaino? ?? ia?aa?ao.

3. I?iaanoe aecia/aiiy ai?noo cae?ca, i?ae? oa eiaaeueoo o ieaci? e
a?eo?ioeeoao e?ia? o iaaeiiioaieo ae?oae c ?aiiueith aiai??th ? a
ia?aae/anii ia?iaeaeaieo iaiiaeyo c ii?iaeueieie iieacieeaie /a?aiii?
e?ia? a aeeiai?oe? i?ioyaii ia?oeo aeaio i?nyoe?a aeeooy.

4. I?iaanoe aeine?aeaeaiiy oeueo?ano?oeoo?e a?eo?ioeeo?a o iaaeiiioaieo
ae?oae c ?aiiueith aiai??th oa aac ia?.

5. Aeaoe ioe?ieo aoaeoeaiino? canoinoaaiiy i?e?iaeaiaio?a o ii?aeiaii? c
iaia?aiinoaa?e?coth/eie i?aia?aoaie aeey i?io?eaeoeee ?aiiuei? aiai??
iaaeiiioaieo ae?oae.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa i?iaaaeaii eiiieaenia aeine?aeaeaiiy ai?noo cae?ca, i?ae?,
eiaaeueoo o ieaci? e a?eo?ioeeoao e?ia? oa oeueo?ano?oeoo?e a?eo?ioeeo?a
o iaaeiiioaieo ae?oae o ia??iae ?o ?aiiuei? aiai?caoe??. Anoaiiaeaii
iniaeeaino? aeeiai?ee iieaciee?a /a?aiii? e?ia? a iaaeiiioaieo ae?oae
caeaaeii a?ae aanoaoe?eiiai oa iinoiaoaeueiiai a?eo, aecia/aii /anoioo
?aiiuei? aiai?? iaaeiiioaieo ae?oae caeaaeii a?ae iane o?ea i?e
ia?iaeaeaii? ? aanoaoe?eiiai a?eo oa ooi/iaii oaeoi?e ?eceeo ??
?icaeoeo. Aia?oa iaoaiaoe/ii aecia/aia ieoiia aaaa aieeao aioa- oa
?io?aiaoaeueieo oaeoi??a ia ?icaeoie ?aiiuei? aiai??. Iieacaii ?ieue
aiaeiaaiii? iaaeinoaoiino? i?e?iaeaiaio?a ? ci?i oeueo?ano?oeoo?e
a?eo?ioeeo?a o iaaeiiioaieo ae?oae o aaiac? ?aiiuei? aiai??, ui
aeicaieeei ?icoe?eoe oyaeaiiy i?i iaoai?ci ?icaeoeo ?aiiuei? aiai??
iaaeiiioaieo ae?oae ? ?ic?iaeoe oaeineiiaeaiee iaoiae ?? i?io?eaeoeee.
Aia?oa iaa?oioiaaii aeioe?euei?noue aeeth/aiiy a caaaeueiee eiiieaen
caoiae?a aeoiaeaeoaaiiy ia?aae/anii ia?iaeaeaieo iaiiaeyo c ?eceeii
?icaeoeo ?aiiuei? aiai?? i?e?iaeic cae?ca, i?ae?, eiaaeueoo a ii?aeiaii?
c a?oai?iii A.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aecia/aii e?eoa???
oi?ioaaiiy a?oi ae?oae c aenieei ?eceeii ?icaeoeo ?aiiuei? aiai??, ye?
iio?aaothoue aeiaeaoeiaiai i?io?eaeoe/iiai eiiieaeno. ?ic?iaeaii oa
ai?iaaaeaeaii a i?aeoeeo ioi?iie caei?ia’y iaoiae i?io?eaeoeee ?aiiuei?
aiai?? iaaeiiioaieo, i?ae /an ee?i?/ii? ai?iaaoe?? io?eiaii a??ia?aeia
cieaeaiiy /anoioe oa oyaeeino? ia?aa?ao ?aiiuei? aiai?? o iaiiaeyo.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. Cai?iiiiiaaiee
iaoiae i?io?eaeoeee ?aiiuei? aiai?? iaaeiiioaieo ae?oae ai?iaaaeaeaii
a i?aeoeeo ?iaioe a?aeae?eaiue iaoieia?? iaaeiiioaieo ? iiaiia?iaeaeaieo
ae?oae Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, Euea?anueeiai iaeaniiai
ia?eiaoaeueiiai oeaio?o, Euea?anueei? i?nueei? aeeoy/i? ee?i?/ii?
e?ea?i? oa Ae?iaiaeoeueeiai i?nueeiai iieiaiaiai aoaeeieo. Ca
iaoa??aeaie aeena?oaoe?? aeaeaii ?ioi?iaoe?eiee eeno “Iaoiae
i?io?eaeoeee ?aiiuei? aiai?? iaaeiiioaieo ae?oae”.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa ? iniaenoith i?aoeath
aaoi?a. I?aea??, ee?i?/ia ianoaaeaiiy oai?eo, aea/aiiy ee?i?ei –
aaiaoieia?/ii? aoaeoeaiino? cai?iiiiiaaiiai i?io?eaeoe/iiai eiiieaeno
aeeiiai? aaoi?ii naiino?eii. Iniaenoi i?iaaaeaiee aiae?c ?acoeueoao?a
aeine?aeaeaiue ?c canoinoaaiiyi noaoenoe/ii? i?ia?aie “Statgraphics”.
Aaoi?ii noai?aia eiii’thoa?ia aaca aeaieo ?acoeueoao?a ianoaaeaiiy
ae?oae, iaienai? an? ?icae?ee aeena?oaoe?? ? noi?ioeueiaai? aeniiaee oa
i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeena?oaoe??
iia?aeiieai? e iaaiai?ai? ia I oa II I?aeia?iaeieo iaaee/ieo eiia?anao
nooaeaio?a ? iieiaeeo o/aieo (Oa?iii?eue, 1997, 1998),
iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 100-??//th eaoaae?e
o?c?ieia?? Euea?anueeiai iaaee/iiai oi?aa?neoaoo (Euea?a, 1995),
can?aeaiiyo iaeaniiai oiaa?enoaa aaiaoieia?a (Euea?a, 1998) oa iaeaniiai
oiaa?enoaa iaae?ao??a (Euea?a, 1997), iaoeiai-i?aeoe/iiio can?aeaii?
eaoaae?e oaeoeueoaonueei? oa oieoaeueii? iaae?ao??? EAeIO (Euea?a,1998).

Ioae?eaoe??. Anueiai ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 10
ae?oeiaaieo i?aoeue, c ieo 8 – noaoae ? 2 – oac.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 207 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e, iieno
iaoa??aeo ? iaoiae?a aeine?aeaeaiiy, i’yoe ?icae?e?a aeanieo
aeine?aeaeaiue, caeeth/ii? /anoeie, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e
? nieneo aeei?enoaii? e?oa?aoo?e, ui aeeth/a? 294 aeaea?ae (92
a?o/eciyieo ? ?in?enueeeo, 202 ?iicaiieo aaoi??a), ye? caeiathoue 32
noi??iee. ?iaioa i?i?ethno?iaaia 33 oaaeeoeyie, 14 oioia?ao?yie, 19
?enoieaie, ye? caeiathoue 35 noi??iie.

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy

I?ae /an aeeiiaiiy aeaii? ?iaioe ianoaaeaii 371 ia?aae/anii ia?iaeaeaieo
iaiiaeyo. A?aeiia?aeii aei iinoaaeaieo iaoe ? caaaeaiue, aeine?aeaeaiiy
i?iaiaeeeinue o aeaio a?oiao ae?oae.

Aeey aecia/aiiy /anoioe, oaeoi??a ?eceeo ?icaeoeo ?aiiuei? aiai??
iaaeiiioaieo ? iniaeeainoae ?? ia?aa?ao ie i?iaaee ee?i?ei-aaiaoieia?/i?
ianoaaeaiiy o 284 ia?aae/anii ia?iaeaeaieo iaiiaeyo. Oe? iaiiaeyoa
aa?eoee aei I a?oie. ?icaeoie ?aiiuei? aiai?? niinoa??aaee o 171
iaaeiiioaieo iaiiaeyo, ye? neeaee iniiaio i?aea?oio niinoa?aaeaiue.
E?eoa???i ?? oi?ioaaiiy aoa ??aaiue aaiiaeia?io ieae/a 110 a/e ?
e?euee?noue a?eo?ioeeo?a iaioa 3,5o1012/e i?ney o?aoueiai oeaeiy aeeooy.
Eiio?ieai noaea a?oia c? 113 ia?aae/anii ia?iaeaeaieo iaiiaeyo, a yeeo
iciae aiai?? ia aoei. Aecia/aiiy ai?noo cae?ca, i?ae?, eiaaeueoo o
ieaci? e a?eo?ioeeoao aoee i?iaaaeai? a 54 iaaeiiioaieo ae?oae iniiaii?
i?aea?oie, ye? ia iaee ?ioaeoe?eieo caoai?thaaiue, oa a 20 iaaeiiioaieo
ae?oae eiio?ieueii? i?aea?oie. Aeey ii??aiyiiy aiaeia?/i? aeine?aeaeaiiy
ai?noo i?e?iaeaiaio?a aoee i?iaaaeai? a 12 caei?iaeo aeiiioaieo ae?oae.
Aeine?aeaeaiiy oeueo?ano?oeoo?e ee?oei e?ia? i?iaaaeaia a 10
iaaeiiioaieo ae?oae iniiaii? i?aea?oie ? a 10 i?aeoe/ii caei?iaeo
iaaeiiioaieo ae?oae eiio?ieueii? o 6-oeaeiaaiio a?oe?.

Aeoiaey/e c iinoaaeaii? iaoe e io?eiaieo iiia?aaeiuei ?acoeueoao?a
aeine?aeaeaiue na?aae ae?oae I a?oie, ie i?eoe?eueii aea?aee 87
ia?aae/anii ia?iaeaeaieo iaiiaeyo ?c oaeoi?aie ?eceeo ? aenieith
eiia??i?noth ?icaeoeo ?aiiuei? aiai?? aeey aea/aiiy aoaeoeaiino?
cai?iiiiiaaiiai iaoiaeo i?io?eaeoeee. Oe? ae?oe ooai?eee II a?oio
aeine?aeaeaiue. 50 iaaeiiioaieo ae?oae oe??? a?oie, ye? io?eioaaee
cai?iiiiiaaiee iaie eiiieaen i?io?eaeoeee ?aiiuei? aiai??, a?aeianai?
aei iniiaii? i?aea?oie. I?iaaaeaia ioe?iea aieeao iaoiaeo i?io?eaeoeee
?aiiuei? aiai?? ia na?aaeiueiaeiaiaee i?e??no iane o?ea, ai?no cae?ca,
i?ae?, eiaaeueoo o e?ia? oa aeaye? aaiaoieia?/i? iieacieee. Eiio?ieai
aoea a?oia c 37 iaaeiiioaieo iaiiaeyo, yeei i?iaiaeeany cae/aeiee
aaceniee eiiieaen caoiae?a aeoiaeaeoaaiiy aac aeiaeaoeiaiai i?ecia/aiiy
i?e?iaeaiaio?a.

I?iniaeoeaia niinoa?aaeaiiy ca iiaiia?iaeaeaieie c ?a?no?aoe??th an?o
ee?i?/ieo iieaciee?a aaee ai?iaeiaae onueiai /ano ?o ia?aaoaaiiy o
a?aeae?eaii? iaoieia?? iaaeiiioaieo ? iiaiia?iaeaeaieo ae?oae. On?
eaai?aoi?i? aeine?aeaeaiiy i?iaiaeeeenue a?ae?aco i?ney ia?iaeaeaiiy, ia
2-3 aeaiue aeeooy oa o 2, 4, 6 ? 8-10-oeaeiaaiio a?oe?. Aiaeia?/i?
ianoaaeaiiy o aeiiioaieo ae?oae cae?i/oaaeeny o 4-oeaeiaaiio a?oe?.

Aeey aeeiiaiiy aeaii? ?iaioe aeei?enoiaoaaeeny ee?i?/i?, eaai?aoi?i?,
?ino?oiaioaeuei? oa noaoenoe/i? iaoiaee aeine?aeaeaiiy.

I?iaaaeaii aeaoaeueia aea/aiiy aiaiiaco aaouee?a, ia?aa?ao aaa?oiino?
iaoa??, aeooa?nueeiai aiaiiaco. I?e ioe?ioe? ee?i?/iiai noaio aeeoeie
a?aoiaoaaeenue iana o?ea i?e ia?iaeaeaii? oa aanoaoe?eiee a?e (ca
oeaeith Aaea?ae), iayai?noue i?aiaoaeueii? a?iio?io?? (ca oaaeeoeath
Ae?iaioue?ai?), iniaeeaino? ?aiiueiai oa i?ciueiai iaiiaoaeueiiai
ia??iaeo, a oaeiae e?eoaaeueii-i?io?eaeoe/i? caoiaee, ye?
aeei?enoiaoaaeeny. Ee?i?/ia ianoaaeaiiy aeeth/aei oaeiae aea/aiiy
iniaeeainoae ia?aa?ao ?aiiuei? aiai?? iaaeiiioaieo (ii/aoie ?icaeoeo
caoai?thaaiiy, caaaeuei? neiioiie oai?iae). ?ic?iaeaia ea?oa ianoaaeaiiy
iaaeiiioaiiai iaiiaeyoe, ui i?noeoue 115 iieaciee?a. O an?o
iiaiia?iaeaeaieo o aeeiai?oe? aecia/aee e?euee?noue a?eo?ioeeo?a oa
??aaiue aaiiaeia?io.

Aecia/aiiy eiioeaio?aoe?? i?e?iaeaiaio?a o ieaci? e a?eo?ioeeoao
i?iaiaeeee iaoiaeii aoiiii-aani?aoe?eii? niaeo?ioioiiao??? ia i?eeaae?
AAS-1N (Ea?e Oeaen Eaia, IAe?).

I?aia?aoe inaaeo e?ia? aeey aeaeo?iiii? i?e?ineii?? aiooaaee ca
iaoiaeeeith, iienaiith ?.A.A?tho?iei (1985). Oeueo?aoiie? c??ce aiooaaee
ia oeueo?ai?e?ioii? OIOI-3 ca aeiiiiiaith neeyieo iiae?a, i?eaioiaaieo
ia i?eeaae? NNI-1. Aea/aiiy oa oioia?aooaaiiy iaoa??aeo i?iaiaeeee ca
aeiiiiiaith i?e?ineiia OYIA100E i?e iai?oc? i?enei?aiiy 75 eA ?
ca?eueoaiiyi ia ae?ai? i?e?ineiia 2000o – 124000o.

Noaoenoe/io ia?iaeo io?eiaiiai oeeo?iaiai iaoa??aeo i?iaiaeeee c
aeei?enoaiiyi noaoenoe/ii? i?ia?aie “Statgraphics” (NOA).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

?acoeueoaoe aeeiai?/iiai niinoa?aaeaiiy ca 284 ia?aae/anii ia?iaeaeaieie
ae?oueie iieacaee, ui o an?o iaaeiiioaieo ae?oae aoa aenieee ??aaiue
aaiiaeia?io ? aaeeea e?euee?noue a?eo?ioeeo?a i?e ia?iaeaeaii?, eio??
iaaeae? iinooiiai cieaeoaaeeny. A ia?aae/anii ia?iaeaeaieo iaiiaeyo, a
yeeo o iiaeaeueoiio ?icaeioeany ?aiiy aiai?y, na?aaei?e ??aaiue
aaiiaeia?io oa na?aaeiy e?euee?noue a?eo?ioeeo?a i?e ia?iaeaeaii? aoee
a??ia?aeii ieae/?, i?ae o ae?oae aac aiai??, oa aaea c 4-6-oeaeiaaiai
a?eo e?euee?noue a?eo?ioeeo?a ? ??aaiue aaiiaeia?io a ieo aoee ieae/a
ii?ie. I?i?iaeuei? aaee/eie aaiiaeia?io a??ia?aeii ca’ycai? c ianith
o?ea i?e ia?iaeaeaii? (r=0,78) oa aanoaoe?eiei a?eii aeeoeie (r=0,75). O
ae?oae aanoaoe?eiiai a?eo 31 oeaeaeaiue ? iaioa, ia a?aei?io a?ae a?eueo
c??eeo ae?oae, /a?aiia e?ia oa?aeoa?eco?oueny cia/ii ieae/ei ??aiai
aaiiaeia?io ? ciaioaiith e?euee?noth a?eo?ioeeo?a ? i?e ia?iaeaeaii?, ?
ai?iaeiaae ia?oeo aeaio i?nyoe?a aeeooy (?en1., ?en.2).

?icaeoie ?aiiuei? aiai?? niinoa??aaee o 60 % ianoaaeaieo ae?oae.
Ee?i?/ii aiai?y oa?aeoa?ecoaaeanue ae?ae?noth oe??e ? aeaeeieo neeciaeo
iaieiiie, yea ia?inoaea ia?aeaeueii c? cieaeaiiyi aaiiaeia?io
(r=0,59). O 30,4% ianoaaeaieo ae?oae (c ??aiai aaiiaeia?io ieae/a 80
a/e) c’yaeyeenue ia?nenooth/a oao?ea?ae?y, oao?iiia, niia?eueiaiiy
i?e?inoo iane o?ea, o 12,3% c oeeo ae?oae (i?e ??ai? aaiiaeia?io ieae/a
70 a/e) – ai?ciaee aiiia ? a?aaeeea?ae??. Ie ia niinoa??aaee ee?i?/ieo
neiioii?a aiai?? o ae?oae c ??aiai aaiiaeia?io aeua 80 a/e.

Aiai?y ?icaeioeany o an?o iaiiaeyo aanoaoe?eiiai a?eo iaioa 28 oeaei?a
? ianith o?ea i?e ia?iaeaeaii? iaioa 1000 a, o 96,7% ae?oae – ianith
o?ea 1000-1499 a ? o 94,3% – aanoaoe?eiiai a?eo 28-31 oeaei?a. Ioaea,
?aiiy aiai?y iaaeiiioaieo ? caaaeueiith i?iaeaiith i?aeoe/ii o an?o
iaiiaeyo c aeoaea iaeith ianith o?ea i?e ia?iaeaeaii? ? aanoaoe?eiiai
a?eo 31 oeaeaeaiue ? iaioa. *anoioa ?aiiuei?

?en.1. Eiioeaio?aoe?y aaiiaeia?io (a/e) o ?en.2.
E?euee?noue a?eo?ioeeo?a (x 1012 /e)

iaaeiiioaieo ae?oae caeaaeii a?ae o
iaaeiiioaieo ae?oae caeaaeii a?ae

a?ae aanoaoe?eiiai oa iinoiaoaeueiiai a?eo aanoaoe?eiiai oa
iinoiaoaeueiiai a?eo

aeeoeie aeeoeie

aiai?? o iaaeiiioaieo ae?oae ciaiooaaeanue c? c?inoaiiyi aanoaoe?eiiai
a?eo oa iane o?ea i?e ia?iaeaeaii? (?en.3, ?en.4).

O ae?oae ianith o?ea i?e ia?iaeaeaii? iiiaae 1500 a ? aanoaoe?eiiai a?eo
32 –36 oeaei?a ia?aaaaeaea eaaea (Hb 90…109 a/e) oa na?aaeiuei?
oyaeeino? (Hb 70…89 a/e) oi?ia aiai??, a o ae?oae c aeoaea iaeith
ianith o?ea i?e ia?iaeaeaii? ? aanoaoe?eiiai a?eo 31 oeaeaeaiue ? iaioa
?icaeioeany na?aaeiuei? oyaeeino? oa aeea (Hb 0,05

2 oeaeaeaiue 140,1 1,4 143,2 2,4 >0,05

4 oeaeaeaiue 116,1 1,89 114,2 2,5 >0,05

6 oeaeaeaiue 110,7 1,77 102,9 2,6 0,05

2 oeaeaeaiue 5,38 0,51 5,30 0,47 >0,05

4 oeaeaeaiue 4,38 0,41 4,18 0,38 >0,05

6 oeaeaeaiue 4,02 0,39 3,95 0,30 >0,05

8 oeaeaeaiue 3,51 0,35 3,32 0,25 >0,05

10 oeaeaeaiue 3,84 0,44 3,11 0,31 0,05

na?aaeiueioyaeea oi?ia (Hb 70- 89 a/e) 7 14 13
35 >0,05

oyaeea oi?ia (Hb 0,05

*anoioa aiai?? 22 44 32 86 >0,05

Oaeei /eiii, cai?iiiiiaaiee iaoiae i?io?eaeoeee oi/a ? ia iiaea
iiai?noth caiia?aoe ?icaeoeia? ?aiiuei? aiai??, aea a?i ia? iaai?
ia?aaaae. O a?eueoino? iaaeiiioaieo ae?oae niinoa??aaany iiceoeaiee
aieea aeiaeaoeiaiai aaaaeaiiy i?e?iaeic cae?ca, i?ae? oa eiaaeueoo a
ii?aeiaii? c a?oai?iii A ia na?aaeiueiaeiaiaee i?e??no iane o?ea, ai?no
cae?ca, i?ae? ? eiaaeueoo a e?ia?, e?euee?noue a?eo?ioeeo?a ? ??aaiue
aaiiaeia?io. Canoinoaaiiy cai?iiiiiaaiiai niiniao i?io?eaeoeee ?aiiuei?
aiai?? a iaaeiiioaieo iiaiia?iaeaeaieo /eieei aaeaioeaio ae?th ia
noai /a?aiii? e?ia?, cieaeoth/e oaiie iaae?iiy ??ai?a aaiiaeia?io ?
e?eueeino? a?eo?ioeeo?a, ui a e?ioeaaiio ?acoeueoao? i?eaiaeeoue aei
ciaioaiiy /enea caoai?thaaiue ?aiiueith aiai??th, ni?ey? eaaoiio ??
ia?aa?ao c a?aenooi?noth oyaeeeo oi?i ? ciaioaiiyi /anoioe
na?aaeiueioyaeeeo oi?i aiai??.

Aoaeue-yeeo iia?/ieo ae?e i?io?eaeoe/iiai eiiieaeno iaie ia
ca?a?no?iaaii o aeiaeiiai iiaiia?iaeaeaiiai, ui na?ae/eoue i?i
aacia/i?noue oe??? oa?ai?? ? iiaeeea?noue oe?ieiai canoinoaaiiy a
iaiiaoieia??.

Ia i?aenoaa? aeeeaaeaiiai aeua, iiaeia c?iaeoe aeniiaie i?i
aeioe?euei?noue aeeth/aiiy a eiiieaen caoiae?a aeoiaeaeoaaiiy
iaaeiiioaieo ae?oae c aenieei ?eceeii ?icaeoeo ?aiiuei? aiai?? i?e?iaeic
cae?ca, i?ae?, eiaaeueoo a ii?aeiaii? c a?oai?iii A.

AENIIAEE

1. Aaaeeeaith ee?i?ei-aaiaoieia?/iith iniaeea?noth i?ciueiai
iaiiaoaeueiiai ia??iaeo ia?aae/anii ia?iaeaeaieo ae?oae ? ?icaeoie
?aiiuei? aiai?? iaaeiiioaieo, /anoioa yei? na?aae ianoaaeaieo iaie
iaiiaeyo noaiiaeoue 60 %. *anoioa ?aiiuei? aiai?? ciaioo?oueny c?
c?inoaiiyi aanoaoe?eiiai a?eo oa iane o?ea i?e ia?iaeaeaii?. Iniiaieie
oaeoi?aie ?eceeo ?icaeoeo ?aiiuei? aiai?? ne?ae aaaaeaoe aanoaoe?eiee
a?e 31 oeaeaeaiue ? iaioa, aeoaea iaeo iano o?ea i?e ia?iaeaeaii? (iaioa
1500 a), aanoic, aiai?th aaa?oieo, aaaaoiie?aeaey.

2. O iaaeiiioaieo ae?oae c ?aiiueith aiai??th a e?ia? c’yaey?oueny
cia/ia e?euee?noue o?ainoi?iiaaieo (ia?aaeaaiie?oe/i? oi?ie) ?
aeano?oeoeaieo oi?i a?eo?ioeeo?a (aeano?oeoe?y aai iiaia a?aenooi?noue
ee?oeiieo iaia?ai), ianooiathoue ci?ie aioo??oiueiee?oeiiiai
iaoaaie?cio, ye? a?aeia?aaeathoueny ia oeueo?ano?oeoo?? ee?oei.

3. Ai?no cae?ca, i?ae? oa eiaaeueoo a ieaci? e a?eo?ioeeoao ioiiaeiii?
e?ia? iaaeiiioaieo iaiiaeyo ? a??ia?aeii ieae/ee, i?ae o aeiiioaieo
ae?oae. Iaeieae/ee ??aaiue i?e?iaeaiaio?a o e?ia? niinoa??aa?oueny o
aeeaieiiaaeiiioaieo iaiiaeyo.

4. Iaaeiiioai? ae?oe, a yeeo iaaeae? ?icaeaa?oueny ?aiiy aiai?y, iathoue
a??ia?aeii ieae/? ??ai? cae?ca, i?ae? oa eiaaeueoo a ieaci? e
a?eo?ioeeoao e?ia? ye i?e ia?iaeaeaii?, oae ? ai?iaeiaae ia?oeo aeaio
i?nyoe?a aeeooy ii??aiyii c ia?aae/anii ia?iaeaeaieie ae?oueie c
ii?iaeueieie iieacieeaie /a?aiii? e?ia?. I?aai?ci iaaeiiioaii? aeeoeie
iaaeinoaoiuei caaacia/aiee cae?cii, i?aeaeth ? eiaaeueoii, i?iyaii /iai
? no?ee? a?iioa?ai?y, a?iieoi?ai?y, a?iieiaaeueoai?y. Aiaeiaaiia
iaaeinoaoi?noue oeeo i?e?iaeaiaio?a iiaea aooe iaeiei ?c aaaaoueio
ao?iiaoiaaiaoe/ieo oaeoi??a ?aiiuei? aiai?? iaaeiiioaieo.

5. Canoinoaaiiy i?aia?ao?a cae?ca, i?ae?, ei\aaeueoo ? a?oai?io A a
caaaeueiiio eiiieaen? caoiae?a aeoiaeaeoaaiiy iaaeiiioaieo ae?oae
iiceoeaii aieeaa? ia na?aaeiueiaeiaiaee i?e??no iane o?ea, ai?no cae?ca,
i?ae? oa eiaaeueoo a e?ia?, e?euee?noue a?eo?ioeeo?a ? ??aaiue
aaiiaeia?io o a?eueoino? ia?aae/anii ia?iaeaeaieo iaiiaeyo c aenieei
?eceeii ?icaeoeo ?aiiuei? aiai??; ciaiooth/e oaiie iaae?iiy e?eueeino?
a?eo?ioeeo?a ? ??aiy aaiiaeia?io, ni?ey? cieaeaiith /anoioe ?aiiuei?
aiai?? iaaeiiioaieo ? eaaoiio ?? ia?aa?ao, aeia?a ia?aiineoueny ae?oueie
? ia aeeeeea? iia?/ii? ae??.

I?AEOE*I? ?AEIIAIAeAOe??

1. Aei a?oi ?eceeo ?icaeoeo ?aiiuei? aiai?? iaaeiiioaieo ne?ae
a?aeiineoe ae?oae c aeoaea iaeith ianith o?ea i?e ia?iaeaeaii? (iaioa
1500 a) ? aanoaoe?eiei a?eii 31 oeaeaeaiue ? iaioa, iaiiaeyo,
ia?iaeaeaieo a?ae aaaaoiie?aeii? aaa?oiino?, oa a?ae iaoa??a c
oneeaaeiaiei ia?aa?aii aaa?oiino? (aanoic ? aiai?y aaa?oieo).

2. C iaoith cieaeaiiy /anoioe ?aiiuei? aiai?? iaaeiiioaieo ? oyaeeino?
?? ia?aa?ao an?i iaaeiiioaiei iiaiia?iaeaeaiei c a?oi ?eceeo c 2-3
oeaeiaaiai a?eo i?iaiaeeoe aeiaeaoeia? i?io?eaeoe/i? caoiaee: 1)
i?aia?ao cae?ca – “Aeoeoa?ei-e?aie?” c ?ic?aooieo 2 ia aeaiaioiiai
cae?ca/ea/aeiao, 2) i?aia?aoe i?ae? – “Noeueoao i?ae?” oa eiaaeueoo –
“Eiai?ae” c ?ic?aooieo a?aeiia?aeii 100 iea i?ae?/ea ? 2 iea
eiaaeueoo/ea ia aeiao, 3) a?oai?i A – 8,5 ia/aeiao: 1 e?aiey 30%
ie?eiiai ?ic/eio aeueoa-oieioa?ieo aoeaoaoo ia aeiao. I?ney cae?i/aiiy
i?io?eaeoe/iiai eo?no i?iaeiaaeoaaoe canoinoaaiiy i?aia?ao?a cae?ca c
?ic?aooieo 2 ia aeaiaioiiai cae?ca/ea/aeiao aei iaeii??/iiai a?eo.

3. Aeey i?aiaoaeueii? i?io?eaeoeee ?aiiuei? aiai?? i?iaiaeeoe nai?/ania
aeyaeaiiy ? e?eoaaiiy aiai?? aaa?oieo, aanoico, icaei?iaeaiiy ae?iie
oa?oeeueiiai a?eo.

Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??

1) Aeeiai?ea ai?noo i?ae? a ieaci? e?ia? iaaeiiioaieo ae?oae a ia??iae
aaeaioaoe?? // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y ? a?io?i?y. –
1997. – O.2. – N.292-295.

2) Ai?no eiaaeueoo o ieaci? e?ia? iaaeiiioaieo ae?oae o ia??iae ?o
?aiiuei? aiai?caoe?? // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y ?
a?io?i?y. – 1998. – N 1. – N.61-64.

3) Canoinoaaiiy i?e?iaeaiaio?a oa a?oai?io A aeey i?io?eaeoeee ?aiiuei?
aiai?? iaaeiiioaieo ae?oae // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y ?
a?io?i?y. – 1998. – N 4. – N.134-138.

4) Oaeoi?e ?eceeo ?icaeoeo ?aiiuei? aiai?? o iaaeiiioaieo ae?oae //
E?ea?nueea ni?aaa. – 1998. – N 6. – C.114-117.

5) Aeeiai?ea eiioeaio?aoe?? i?ae? o ieaci? oa a?eo?ioeeoao e?ia? o
iaaeiiioaieo ae?oae c ?aiiueith aiai??th // Aenia?eiaioaeueia oa
ee?i?/ia o?c?ieia?y ? a?io?i?y. – 1999. – N 1. – N.71-76.

6) Aeeiai?ea ai?noo cae?ca a ieaci? oa a?eo?ioeeoao e?ia? o iaaeiiioaieo
ae?oae a ia??iae ?o ?aiiuei? aiai?caoe?? // I?aeoe/ia iaaeeoeeia. –
1999. – N 1-2. – N.43-46.

7) Ci?ie oeueo?ano?oeoo?e a?eo?ioeeo?a ia?eoa?e/ii? e?ia? iaaeiiioaieo
ae?oae c ?aiiueith aiai??th // Aeooaeuei? i?iaeaie iaaeeoeeie, a?ieia??,
aaoa?eia??? ? n?euenueeiai ainiiaea?noaa (eieaa /aoaa?oa): Ca. iaoe.
i?aoeue. – Euea?a, 1998. – C.105-110. (ni?aaao. Eiaaeeoei A.?.,
Aaeaaioeueeee I.?.).

8) Ea?oeia ia?eoa?e/ii? e?ia? a iaaeiiioaieo ae?oae ia?oeo aeaio
i?nyoe?a aeeooy // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y: Ca. iaoe.
i?aoeue aei 100-??//y eao. o?c?ieia?? Euea?anueeiai iaae. oi-oo. –
Euea?a, 1995. – N.286-288.

9) ?aiiy aiai?y iaaeiiioaieo: /anoioa oa iniaeeaino? ?? ia?aa?ao //
Iaoa??aee I I?aeia?iaeiiai iaaee/iiai eiia?ano nooaeaio?a ? iieiaeeo
a/aieo. – Oa?iii?eue, 1997. – N.100.

10) Aeeiai?ea ai?noo eiaaeueoo a ieaci? e?ia? iaaeiiioaieo ae?oae a
ia??iae ?o ?aiiuei? aiai?caoe?? // Iaoa??aee II I?aeia?iaeiiai
iaaee/iiai eiia?ano nooaeaio?a ? iieiaeeo a/aieo. – Oa?iii?eue, 1998. –
N.183.

AIIIOAOeEss

Nae?aoa?ue E.A. Iaoiaaiaoe/aneia iainiiaaiea i?eiaiaiey iee?iyeaiaioia
niaianoii n aeoaieiii A aeey i?ioeeaeoeee ?aiiae aiaiee iaaeiiioaiiuo
aeaoae. – ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.10 – iaaeeao?ey.

?aaioa iinayuaia ?ac?aaioea eiiieaeniie nenoaiu i?ioeeaeoeee ?aiiae
aiaiee iaaeiiioaiiuo aeaoae ia iniiaaiee eco/aiey iniaaiiinoae aa
i?ioaeaiey, oaeoi?ia ?enea ?acaeoey ?aiiae aiaiee, ii?aaeaeaiey
niaea?aeaiey iee?iyeaiaioia a e?iae e enneaaeiaaiey oeueo?ano?oeoo?u
y?eo?ioeeoia.

Ianeaaeiaaii 371 i?aaeaeaa?aiaiii ?iaeeaoeony aeaoae, eioi?ui a
aeeiaieea ii?aaeaeaii niaea?aeaiea aaiiaeiaeia e eiee/anoai
y?eo?ioeeoia. O anao iaaeiiioaiiuo aeaoae aue aunieee o?iaaiue
aaiiaeiaeia e eiee/anoai y?eo?ioeeoia i?e ?iaeaeaiee, eioi?ua a
aeaeueiaeoai iinoaiaiii oiaiueoaeenue. O aeaoae aanoaoeeiiiiai aic?anoa
31 iaaeaey e iaiueoa, a ioee/ea io aieaa c?aeuo aeaoae, e?aniay e?iaue
oa?aeoa?eciaaeanue cia/eoaeueii aieaaa ieceei o?iaiai aaiiaeiaeia e
eiee/anoaii y?eo?ioeeoia eae i?e ?iaeaeaiee, oae e ia i?ioyaeaiee ia?auo
aeaio ianyoeaa aeecie.

?acaeoea ?aiiae aiaiee iaaeiiioaiiuo iaaethaeaee o 60% ianeaaeiaaiiuo
aeaoae. ?aiiy aiaiey aicieeea i?aeoe/anee o anao aeaoae aanoaoeeiiiiai
aic?anoa 31 iaaeaey e iaiueoa e ianie oaea i?e ?iaeaeaieee iaiueoa
1500a. *anoioa ?aiiae aiaiee iaaeiiioaiiuo oiaiueoaaony n ain?inoaieai
aanoaoeeiiiiai aic?anoa e ianu oaea i?e ?iaeaeaiee. Iniiaiuie oaeoi?aie
?enea ?acaeoey ?aiiae aiaiee iaaeiiioaiiuo neaaeoao n/eoaoue
aanoaoeeiiiue aic?ano 31 iaaeaey e iaiueoa, i/aiue iaeoth iano oaea i?e
?iaeaeaiee (iaiueoa 1500a), aanoic, aiaieth aa?aiaiiuo, iiiaiieiaeea.

I?iaaaeaii enneaaeiaaiea niaea?aeaiey aeaeaca, iaaee e eiaaeueoa a
ieacia e y?eo?ioeeoao a 74 iaaeiiioaiiuo aeaoae e 12 aeiiioaiiuo aeaoae.
Niaea?aeaiea aeaeaca, iaaee e eiaaeueoa a ieacia e y?eo?ioeeoao
ioiiaeiiie e?iae iaaeiiioaiiuo aeaoae aeinoiaa?ii ieaea, /ai o
aeiiioaiiuo aeaoae. Naiue ieceee o?iaaiue iee?iyeaiaioia a ioiiaeiiie
e?iae iaaethaeaeny a aeoaieiiaaeiiioaiiuo aeaoae, o eioi?uo a
aeaeueiaeoai ?acaeaaeenue oyaeaeua oi?iu aiaiee, n oaaee/aieai
aanoaoeeiiiiai aic?anoa n?aaeiea cia/aiey iee?iyeaiaioia oaaee/eaaeeny.
Eiioeaio?aoeee yoeo iee?iyeaiaioia a ioiiaeiiie e?iae aeaoae,
?iaeaeaiiuo io iaoa?ae n aiaieae, aanoicii, a oaeaea o aeaoae-aeeciaoeia
e o aeaoae n aioo?eoo?iaiie aeiio?ioeae auee iaiueoa, /ai o aeaoae,
eioi?ua ia eiaee oeacaiiuo oaeoi?ia ?enea a aioa- e iinoiaoaeueiie
aeecie. I?aaeaeaa?aiaiii ?iaeeaoeany aeaoe, o eioi?uo a aeaeueiaeoai
?acaeaaeanue ?aiiyy aiaiey, eiatho aeinoiaa?ii ieaea o?iaie aeaeaca,
iaaee e eiaaeueoa a ieacia e y?eo?ioeeoao e?iae eae i?e ?iaeaeaiee, oae
e ia i?ioyaeaiee ia?auo aeaio ianyoeaa aeecie a n?aaiaiee n
iaaeiiioaiiuie aeaoueie n ii?iaeueiuie iieacaoaeyie e?aniie e?iae.
I?aaieci iaaeiiioaiiiai ?aaaiea iaaeinoaoi/ii iaania/ai aeaeacii,
iaaeaeth e eiaaeueoii, i?iyaeaieai /aai anoue noieeea aeiioa?aiey,
aeiieoi?aiey e aeiieiaaeueoaiey o aeaoae n ?aiiae aiaieae.

Enneaaeiaaia oeueo?ano?oeoo?a y?eo?ioeeoia a 10 iaaeiiioaiiuo aeaoae n
?aiiae aiaieae e aac aiaiee.O iaaeiiioaiiuo aeaoae n ?aiiae aiaieae a
e?iae iaaethaeaaony aieueoia eiee/anoai o?ainoi?ie?iaaiiuo
(i?aaeaaiieeoe/aneea oi?iu) e aeano?oeoeaiuo oi?i y?eo?ioeeoia
(aeano?oeoeey e iieiia ionoonoaea eeaoi/iuo iaia?ai), ianooiatho
eciaiaiey aioo?eeeaoi/iiai iaoaaieecia, eioi?ua io?aaeathony ia
no?oeoo?a eeaoie.

Iieacaia ?ieue yiaeiaaiiie iaaeinoaoi/iinoe iee?iyeaiaioia e eciaiaiee
oeueo?ano?oeoo?u y?eo?ioeeoia o iaaeiiioaiiuo aeaoae a aaiaca ?aiiae
aiaiee. Ia iniiaaiee iieo/aiiuo aeaiiuo ?ac?aaioai iaoiae i?ioeeaeoeee
?aiiae aiaiee iaaeiiioaiiuo aeaoae: eiiieaeniia i?eiaiaiea
iee?iyeaiaioia a ni/aoaieee n aeoaieiii A n 2-3 iaaeaeueiiai aic?anoa ia
i?ioyaeaiee 7-8 iaaeaeue. I?eiaiaiea i?aia?aoia aeaeaca, iaaee,
eiaaeueoa e aeoaieia A a iauai eiiieaena ia?ii?eyoee auoaaeeaaiey
iaaeiiioaiiuo aeaoae iieiaeeoaeueii aeeyao ia n?aaeiaaeiaiaoth i?eaaaeo
ianu oaea, niaea?aeaiea aeaeaca, iaaee e eiaaeueoa a e?iae, eiee/anoai
y?eo?ioeeoia e o?iaaiue aaiiaeiaeia o aieueoeinoaa i?aaeaeaa?aiaiii
?iaeeaoeony aeaoae n aunieei ?eneii ?acaeoey ?aiiae aiaiee. ?aiiyy
aiaiey iaaeiiioaiiuo ?acaeioeanue o 44% i?aaeaeaa?aiaiii ?iaeeaoeony
aeaoae, eioi?ua iieo/aee eiiieaen iee?iyeaiaioia n aeoaieiii A, a
n?aaiaiee n 86% aeaoae eiio?ieueiie a?oiu. N?aaee aeaoae iniiaiie a?oiu
i?aiaeaaeaee eaaeea oi?iu aiaiee (30%) e nianai ia auei oyaeaeuo oi?i. O
8% aeaoae eiio?ieueiie a?oiu ?acaeioeany oyaeaeay oi?ia aiaiee e o 35%
aeaoae – aiaiey n?aaeiae oyaeanoe. I?aaeeiaeaiiue i?ioeeaeoe/aneee
eiiieaen eiaao aaeaioeaiia aeeyiea ia ninoiyiea e?aniie e?iae, oiaiueoay
oaiiu iaaeaiey eiee/anoaa y?eo?ioeeoia e o?iaiy aaiiaeiaeia, e, oaeei
ia?acii, niinianoaoao oiaiueoaieth /anoiou ?aiiae aiaiee iaaeiiioaiiuo
aeaoae e aieaa eaaeiio aa i?ioaeaieth, oi?ioi ia?aiineony aeaoueie e ia
aucuaaao iiai/iuo aeaenoaee.

Eeth/aaua neiaa: iaaeiiioaiiua aeaoe, ?aiiyy aiaiey, iee?iyeaiaiou,
y?eo?ioeeou, oeueo?ano?oeoo?a.

SUMMARY

Sekretar L.B. – Pathogenic substantiation of microelements usage with
vitamin E for early anemia of prematurity prophylaxis. – Manuscript.

Thesis for scientific degree of candidate of medical sciences by
speciality 14.01.10 – Pediatrics. – Institute of Pediatrics, Obstetrics
and Gynecology, Academy of Medical Sciences of Ukraine, Kyiv, 1999.

The work is dedicated to the elaboration of the complex system for early
anemia of prematurity prophylaxis based on the study of peculiarities
it’s clinical course, assesment of the trace elements serum levels, and
study of the red cells ultrastructure. It was established that premature
babies were deficient in iron, copper, cobalt, and manganese.
Hypoferrumia, hypocopperemia, and hypocobaltemia characterized the
course of early anemia of prematurity. The role of endogenic deficiency
of the trace elements was determined in pathogenesis of early anemia of
prematurity. Based on the data obtained the new method for early anemia
of prematurity prophylaxis was elaborated. The method allow reducing of
frequency of early anemia and less severity course.

Key words: premature infants, early anemia of prematurity,
microelements, erythrocytes, ultrastructure.

AIIOAOe?ss

Nae?aoa? E.A. Iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy i?e?iaeaiaio?a o
ii?aeiaii? c a?oai?iii A aeey i?io?eaeoeee ?aiiuei? aiai??
iaaeiiioaieo ae?oae. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoe iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.10 – iaae?ao??y.

?iaioa i?enay/aia ?ic?iaeaiith eiiieaenii? nenoaie i?io?eaeoeee ?aiiuei?
aiai?? iaaeiiioaieo ia i?aenoaa? aea/aiiy iniaeeainoae ?? ia?aa?ao,
aecia/aiiy ai?noo i?e?iaeaiaio?a o e?ia? oa aeine?aeaeaiiy
oeueo?ano?oeoo?e a?eo?ioeeo?a. Anoaiiaeaii, ui i?aai?ci iaaeiiioaii?
aeeoeie iaaeinoaoiuei caaacia/aiee cae?cii, i?aeaeth oa eiaaeueoii,
i?iyaii /iai ? no?ee? a?iioa?ai?y, a?iieoi?ai?y oa a?iieiaaeueoai?y o
iaiiaeyo c ?aiiueith aiai??th. Iieacaii ?ieue aiaeiaaiii? iaaeinoaoiino?
i?e?iaeaiaio?a oa ci?i oeueo?ano?oeoo?e a?eo?ioeeo?a o iaaeiiioaieo
ae?oae a aaiac? ?aiiuei? aiai??. Ia i?aenoaa? io?eiaieo aeaieo
?ic?iaeaii iaoiae i?io?eaeoeee ?aiiuei? aiai?? iaaeiiioaieo ae?oae, yeee
ni?ey? ciaioaiith /anoioe ?aiiuei? aiai?? oa a?eueo eaaeiio ?? ia?aa?ao.

Eeth/ia? neiaa: iaaeiiioai? ae?oe, ?aiiy aiai?y, i?e?iaeaiaioe,
a?eo?ioeeoe, oeueo?ano?oeoo?a.

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