I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO

IIEIEIA?? oa ?AAe?IEIA??

AOAIANUe?AA Iaoae?y ?aai?aia

OAeE 616-073.916:616.44+614.876(477)

IAOIAAIAOE*IA IAA?OIOOAAIIss CANOINOAAIIss

EIIIEAENO I?IIAIAAEO IAOIAe?A AeENA?OAOe?E A

AeENIAINA?IIIO IAAEssAe? O*ANIEE?A E?EA?AeAOe??

IANE?AeE?A AAA??? IA *AAN ?C OE?AI?AeIITH IAOIEIA??TH

14.01.23 — i?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y

A A O I ? A O A ? A O

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oa?e?anueeiio IAe? iaaee/ii? ?aae?ieia?? ?i.A?eai??aa
IIC Oe?a?ie.

IAOEIAee EA??AIEE:

Ieeeiaiei I.?. aeieoi? iaaee/ieo iaoe, i?ioani? — aee?aeoi?
Oa?e?anueeiai IAe? iaaee/ii? ?aae?ieia?? ?i.A?eai??aa IIC Oe?a?ie.

IO?Oe?EI? IIIIAIOE:

A.Ae. *aaioa?ueaa, ae.i.i., i?io., aieiaiee iaoeiaee ni?a?ia?oiee
a?aeae?eaiiy ?aae?aoe?eii? iieieia?? ? yaea?ii? iaaeeoeeie Oe?a?inueeiai
IAe? iieieia?? oa ?aae?ieia??.

A.I. Neaaiia ae.i.i., i?io., i?ia?aeiee iaoeiaee ni?a?ia?oiee
eaai?aoi??? ?aae?ieia?? IAe? aiaeie?eiieia?? ? iai?io ?a/iaei ?i. A.I.
Eii?na?aiea AII Oe?a?ie.

A.A.Aaaaoei, ae.i.i., i?io., canooiiee aaia?aeueiiai aee?aeoi?a
Iaoeiaiai oeaio?o ?aae?aoe?eii? iaaeeoeeie AII Oe?a?ie c iaoeiai?
?iaioe, aee?aeoi? ?inoeoooo ee?i?/ii? ?aae?ieia?? iaoeiaiai oeai?o
?aae?aoe?eii? iaaeeoeeie AII Oe?a?ie.

I?IA?AeIA ONOAIIAA:

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i.I.E.Ooieea,
eaoaae?a iaaee/ii? ?aae?ieia??

Caoeno a?aeaoaeaoueny “11”_11_1999_?. i 10_aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.619.01 a Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? iieieia?? oa ?aae?ieia?? IIC Oe?a?ie
(252022, i. Ee?a, aoe. Eiiiiiniaa, 33/43).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo iieieia?? oa ?aae?ieia?? IIC Oe?a?ie

(i. Ee?a, aoe. Eiiiiiniaa, 33/43).

Aaoi?aoa?ao ?ic?neaiee “9_”_10___1999_?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe Aeeeai ?.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue ?iaioe. Iaeii?th c aeooaeueieo i?iaeai no/anii? iaaee/ii?
iaoee ? aea/aiiy aoaeoia o?eaaei? aei? iecueei ?ioaineaiiai ii?iiiiaiiy
ia nenoaie i?aaiicio. Iniaeeai? aaae oey i?iaeaia iaaoea iiney aaa?i? ia
*i?iiaeeuenueeie AAN. sseui a?aooaaoe oa, ui iiae /an aaa?i? i a
iiaeaeueoiio a aoiinoa?o aoei aeeeiooi cia/io eieueeinoue icioiiia
?aaeiiaeoeaiiai eiaeo, o?iiieo aei ueoiaeaeii? caeice, noa? c?icoiieei
aaaeeeainoue aeineiaeaeaiue, ni?yiiaaieo ia aea/aiiy noaio nenoaie
aiiioic — ueoiaeaeia caeica ia oieueee o iaoeaioeia “caa?oaeiaieo”
oa?eoi?ie, a i o aaciina?aaeiio o/anieeia eieaiaeaoei? ianeiaeeia aaa?i?
ia *AAN (I.O.Aiciaiia, 1996). Ia aeoieo ie?aieo aaoi?ia, c?inoaiiy
eieueeinoi aeiaaeeia ?aeo ia ca’ycaii c aaa?ieiei ii?iiiiaiiyi ianaeaiiy
(A.A.Eieaeieeia, 1992). Aaaaeathoue, ui o “iaecaa?oaeiaiioeo” ?aeiiao
nia?oiinoue aiae ?aeo c?inoa ia 10-20 aeiaaeeia ia ?ie ia eiaeii 100 000
ianaeaiiy, i?e/iio aiaeaoaeaoueny oea ia ?aiioa, iiae /a?ac 40-60 ?ieia,
oieueee aei oiai /ano i ciiaeooue iiaiinoth ?icaeiooenue oi ?aeiai
caoai?thaaiiy, ui aoee coiiaeaii aei?th aei?iiiiaiiy (N.I.ss?iiiaiei i
niiaaao., 1992).

Iiaeeeai, oaei aeoiee i aoee aei?aaaeaii /a?ac 6 ?ieia iiney
?aaeiaoeieii? eaoano?ioe, aea aeeiaii/ia niinoa?aaeaiiy ca noaiii
caei?ia’y ianaeaiiy ia oieueee Oe?a?ie, a oiio /enei i eieaiaeaoi?ia
aaa?i? ia *AAN, aiaee?eei aeaui iioo ea?oeio. Ni?aaaei, ?aaeiaoeieia
aaa?iy, iiae /an yei? na?aae 200 ?icieo ?aaeiiioeeiaeia, aeeeiooeo a
iiaio?y, 20% aoee icioiiaie eiaeo, ia iiaea ia iicia/eoenue ia
ooieoeiiiaeueiiio noaii ueoiaeaeii? caeice (i.A. Eiooa?ueia i niiaaao.,
1991; A.?.?iiaiaiei i niiaaao., 1991; A.I.Ae?aeia i niiaaao., 1993;
A.O.Oeea, 1998).

O no/aniie iaaee/iie iaoeiaie eioa?aoo?i aeinoaee aiaeia?aaeaiiy oi
aeeiaii/ii oaiaeaioei?, ui noinothoueny noaio ueoiaeaeii? caeice o
iineyaaa?ieiee ia?iiae. Aiaecia/aii c?inoaiiy, o ii?iaiyiii c
aeiaaa?ieiei ia?iiaeii, caoai?thaaiue ueoiaeaeii? caeice, cie?aia
oe?aioieneeico, aeeoocii? no?oie, ciaa Oaoeiioi, iineeaiiy ciaii?
aiaeaii? (A.A.Eaeiiii i niiaaao., 1992; I.I.Eyuoe i niiaaao., 1993), ui
iaoiiaeth?oueny ye ianeiaeeaie aaa?i? ia *AAN (Z.Wang i niiaaao., 1990;,
A.O.Oeea, 1991, O.E.Iaaooioiee i niiaaao., 1993), oae i no?ani?iith
aei?th i aieeaii iioeo oeiaeeeaeo /eiieeia ciaiioiueiai na?aaeiaeua
(A.I.Iai/ei i niiaaao.,1992; A.A.Aa?aaie, 1996).

Aacoiiaii, iaeaieueoiai eeiiioo caaaeathoue iiaiaeiieaiiy uiaei
iioe?aiiy oe?ai?aeiiai ?aeo na?aae aeeoy/iai i aei?ineiai ianaeaiiy, yea
iaoea? ia “caa?oaeiaieo” ?aaeiiioeeiaeaie oa?eoi?iyo. Oae, ca ia?iiae c
1986 ii 1990 ??. eieueeinoue aeiaaeeia ?aeo ueoiaeaeii? caeice c?inea o
5 ?acia (A.E.*aaai i niiaaao., 1991; I.?.I?ieiiaiei i niiaaao., 1992).

Ona oea coiiaeth? aeooaeueiinoue aeineiaeaeaiue iniaeeainoae ia?aaiao i
iaoiaaiaco caoai?thaaiue ueoiaeaeii? caeice i ?ic?iaee aeeniaina?ieo
caoiaeia a o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? (EIA) ia *AAN c
oe?ai?aeiith iaoieiai?th a no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao
Oe?a?ie, yei neeaeeny iiney aaa?i? ia *AAN.

Iaoa aeineiaeaeaiiy:

Ia iiaenoaai aeei?enoaiiy i?iiaiaaeo iaoiaeia aeiaaiinoeee aecia/eoe
iaoiaaiaoe/ii iaoaiicie ?icaeoeo oe?ai?aeii? iaoieiai? a o/anieeia
eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN oa noai?eoe nenoaio ?o
aeeniaina?iiai iaaeyaeo aeey iiiiiicaoei? noioanoe/ieo oe?ai?aeieo
aoaeoia.

Caaaeaiiy aeineiaeaeaiiy:

1. I?iaiaeicoaaoe aeeiaiieo aeieeiaiiy aeeoocii? (caieueoaiiy UC Ia-II
no.) oa aiaieuaai? oe?ai?aeii? iaoieiai? a inia, ui a?aee o/anoue o
eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN.

2. Cinoaaeoe /anoioo i oa?aeoa? iaoieiai? ueoiaeaeii? caeice o
iaoeaioeia noiaeo Oe?a?ie oa o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia
*AAN c oeueiai ?aaiiio (ca aeiiiiiaith eeiiiei-aoineiii/ieo
aeineiaeaeaiue).

3. Oeyoii canoinoaaiiy ?aaeiiiioiiiai aiaeico (?IA) aea/eoe iniaeeainoi
oe?ai?aeiiai ai?iiiaeueiiai noaio i?e caoai?thaaiiyo ueoiaeaeii? caeice
(aooiiioiiee oe?ai?aeeo, aoceiaee cia) oa i?e aeeoociiio caieueoaiii
ueoiaeaeii? caeice Ia-II no. a o/anieeia eieaiaeaoei? ianeiaeeia aaa?i?
ia *AAN o ii?iaiyiii c iaoeaioeyie noiaeo Oe?a?ie.

4. Aecia/eoe nooiiiue iioiieiai/ieo ii?ooaiue a o/anieeia EIA ia *AAN,
ii?iaiyii c iaoeaioeyie noiaeo Oe?a?ie c aiaeiai/iith oe?ai?aeiith
iaoieiai?th.

5. Aecia/eoe, /e ? aeeoocia caieueoaiiy ueoiaeaeii? caeice Ia-II co. o
no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao aacia/iei noaiii (aa?iaioii
oiciieiai/ii? ii?ie).

6. I?iaiaeicoaaoe ii?oieiai/ii iniaeeainoi ia?aaiao iaoieiai?
ueoiaeaeii? caeice o aeeiaiioei aei- i iineyaaa?ieiiai ia?iiaeo a
Oe?a?ii.

7. Aecia/eoe ?ieue oa iinoea i?iiaiaaeo iaoiaeia aeiaaiinoeee (OCAe,
?IA) a nenoaii aeeniaina?iiai iaaeyaeo ca o/anieeaie EIA ia *AAN c
iaoieiai?th ueoiaeaeii? caeice c iaoith iiiiiicaoei? aiaeaeaeaieo
noioanoe/ieo oe?ai?aeieo aoaeoia.

Iaoeiaa iiaecia:

A ?acoeueoaoi canoinoaaiiy i?iiaiaaeo iaoiaeia in vivo oa in vitro
aeiaaiinoeee a eiiieaeniiio aaaaoi?iaiaaiio eeiiiei-eaai?aoi?iiio
aeineiaeaeaiii aia?oa aeyaeaii iaaiaeiii ?aiioa caeiiiii?iinoi
iioiiai?iiiaeueieo aca?iiaiaeiinei i?e oe?ai?aeiie iaoieiai? a o/anieeia
EIA ia *AAN oa iaoaiicie ?? aeieeiaiiy i ia?aaiao. Aia?oa oeyoii
eeiiiei-aoineiii/iiai ne?eiiiao aea/aii aeeiaiieo aeieeiaiiy aeeoocieo i
aiaieuaaeo oe?aiiaoie o eieaiaeaoi?ia aaa?i? ia *AAN o caeaaeiinoi aiae
oa?aeoa?o, /ano aei? ?aaeiaoeieiiai /eiieea i nooiaiy aeiciaiai
iaaaioaaeaiiy. C o?aooaaiiyi ?aaeiiiioiieiai/iiai aeeiaii/iiai
aeineiaeaeaiiy ai?iiiaeueiiai oa iioiiiai noaio aeiaaaeaii, ui aeeoocia
caieueoaiiy ueoiaeaeii? caeice Ia-II co. aeaeaei ia caaaeaee ? aa?iaioii
ii?ie, a aoaa? oiiii, ia yeiio ?icaeaa?oueny i?aaii/ia oe?ai?aeia
iaoieiaiy, i oiio iio?aao? aiaeiiaiaeiiai aeeniaina?iiai iaaeyaeo, a i?e
iaiaoiaeiinoi — i ei?aeoei? ooieoeiiiaeueieo c?ooaiue; oea
aiae?iciy?oueny aiae aeoiee i?i caaaeaee oiciieiai/iee oa?aeoa? i
aaiaeueiinoue aeeoociiai caieueoaiiy ueoiaeaeii? caeice. Ia iiaenoaai
aiaeico /eneaiieo aeaieo aeiaaaeaii ia?aeaeici o c?inoaiii a inoaiii
?iee aeia?iyeinii? oa ceiyeinii? iaoieiai? ueoiaeaeii? caeice, ui
aecia/a? iiaeeeainoue i?ioieaeoeee ?icaeoeo oe?ai?aeiiai ?aeo ca
aeiiiiiaith nai?/aniiai ?aaeeeaeueiiai eieoaaiiy aeia?iyeinii? oa
ia?aaeiooeeiii? iaoieiai? ueoiaeaeii? caeice. Aeiaaaeaii iiaeeeainoue
aeieeiaiiy ?aeo ueoiaeaeii? caeice ia oei aooiiioiii? oe?ai?aeii?
iaoieiai? a no/anieo oiiaao, ui ia?aaeaa/a? iaiaoiaeiinoue ?ic?iaee
nenoaie aeeniaina?ieo i iaaieo aeiaaiinoe/ieo caoiaeia, c iaoith
caiiaiaaiiy iaiieanoe/iiio i?ioeano a ueoiaeaeiie caeici o iaoei?ioia,
ui noaiiaeyoue a?oie ?eceeo. Iaoiaaiaoe/ii iaa?oioiaaii iiaeeeainoue
inioaaiiy aeayeeo iiaeo ?aeo?nia iaoaiicio aiiioe?aico, ui aeieea? o
eieaiaeaoi?ia aaa?i? ia *AAN, i noi?iaiaeaeo? oe?ai?aeio iaoieiaith o
oeeo inia.

Oia?oa aeneiaeaii aeoieo i?i iiaeeeainoue inioaaiiy a o/anieeia EIA ia
*AAN ia oieueee noaeeiii/iiai ia?aeiiiai aiiioe?aico aianeiaeie i?yiiai
ooeiaeaeoth/iai aieeao ?aaeiiaeoeaieo icioiiia eiaeo ia ueoiaeaeio
caeico (ia?aaoaaiiy a ciii aaa?i? a “eiaeiiio ia?iiaei» i aieeao
iiaeaeuaii? ia’?iii? aeoeaiinoi 131I, ui niinoa?iaaeiny a i. Oa?eia? o
ia?oi iineyaaa?ieii aeii), a i noaeeiii/ieo iciae i?eaii/aiiy
oe?aio?iiii? ooieoei? aiiioica, i/aaeaeii, aianeiaeie ?aaeiaoeieiiai
aieeao ia no?oeoo?e iiceo (aiiioaeaion, aiiioic); iai?yii? ?aaeiaoeieii?
aei? oa no?ani?ieo aoaeoia.

Oia?oa ia iniiai eiiieaeniiai ii?iaiyeueiiai aiaeico noaio iioiii?
nenoaie i?e iaeaieueo ?iciianthaeaeaiie iaoieiai? ueoiaeaeii? caeice a
o/anieeia EIA ia *AAN i iaoeaioeia noiaeo Oe?a?ie aeneiaeaii aeoieo i?i
aeayei iiai iiaeeeai iaoiaaiaoe/ii iaoaiicie ?icaeoeo iino?aaeiaoeieiiai
aooiiioiiiai oe?ai?aeeoo.

Oai?aoe/ia i i?aeoe/ia cia/aiiy ?iaioe.

Ia iiaenoaai i?iaaaeaieo ?aaeiiiioiieiai/ieo aeineiaeaeaiue caeiaooi
iiai aeaii i?i noai aiiioica?ii-oe?ai?aeii? nenoaie o ?icii oa?iiie
iiney aieeao iiiicoaaeueii? ?aaeiaoei? a o/anieeia EIA ia *AAN c
aeeoociei caieueoaiiyi ueoiaeaeii? caeice Ia-II no., oe?ai?aeiith
iaoieiai?th (AIO, AC) oa aac ia? ? iniaeeainoi iino?aaeiaoeieieo ciii
iaoaiiciia iioiiai?iiiaeueii? ?aaoeyoei? i?e aeieeiaiii oe?ai?aeii?
iaoieiai?.

C o?aooaaiiyi aeyaeaieo oaeoia ?ic?iaeaii nenoaio no?oeoo?e
aeeniaina?iiai iaaeyaeo ca o/anieeaie EIA ia *AAN c oe?ai?aeiith
iaoieiai?th, iaa?oioiaaii ?ieue oa iinoea i?iiaiaaeo in vitro oa in vivo
aeineiaeaeaiue o oeie nenoaii, ui ni?yiiaaii ia iieiioaiiy yeinoi
aeiaaiinoeee caoai?thaaiue ueoiaeaeii? caeice.

?ic?iaeaii aeiiiii/ii aeaiaeiee aeiaaiinoe/iee eiiieaen, ni?yiiaaiee ia
nai?/anio aa?eoieaoeith ye aeeoocii?, oae i aiaieuaai? oe?ai?aeii?
iaoieiai? a o/anieeia EIA ia *AAN, caieueiaiee aiae aeiaeaoeiaiai
i?iiaiaaiai iaaaioaaeaiiy ia i?aaiici oai?iai, i aeiaaaeaii eiai
aoaeoeaiinoue.

Aeey canoinoaaiiy o i?aeoe/iie iaaeeoeeii cai?iiiiiaaii aeaeieyoe
aeeoocio oa aeeoocii-aoceiao oi?ie AIO ca oiia niiieiai/iiai oa
oeeoieiai/iiai iiaeoaa?aeaeaiiy aiaeiiaiaeieo iciae aooiiioiiiai
i?ioeano a ia?aioiii ueoiaeaeii? caeice oa aoceiaiio ooai?aiii.

Ia oei aiaeico eiiieaeno eeiiiei-aoi-?aaeiiiioiieiai/ieo aeineiaeaeaiue
aiaieuaaeo oi?i caoai?thaaiue ueoiaeaeii? caeice (AC, AIO
aeeoocii-aoceiaa oi?ia) ?ic?iaeaii e?eoa?i? oi?ioaaiiy a?oie ?eceeo
uiaei ?icaeoeo oe?ai?aeiiai ?aeo oa ?aeiiaiaeaoei? aei
aeeoa?aioeieiaaii? eieoaaeueii? oaeoeee (eiina?aaoeaia oa?aiiy,
oi?o?ai/ia eieoaaiiy) o/anieeia EIA c oe?ai?aeiith iaoieiai?th.

I?aeoe/ii ?aeiiaiaeaoei? iiaeooue aooe ai?iaaaeaeaii a ?iaioo oeaio?ia
?aaeiaoeieiiai caoenoo ianaeaiiy oa aiaeie?eiieiai/ieo oeaio?ia aac
aeiaeaoeiaiai aeeaaeaiiy eiooia, aea ca iayaiinoi aenieieaaeioieiaaieo
niaoeiaeinoia — ?aaeiieiaa, aiaeie?eiieiaa, OC-aeiaaiinoa oa
eiea?y-oeeoieiaa.

Iniaenoee aianie aeena?oaioa o ?ic?iaeo iaoeiaeo ?acoeueoaoia, ui
aeiinyoueny ia caoeno.

Aaoi?ii aeena?oaoeieii? ?iaioe iniaenoi ?ic?iaeaii i?ia?aio i
iaoiaeieiaith aeineiaeaeaiue, aeeiiaii ani eeiii/ii aeineiaeaeaiiy,
naiinoieii i?iaaaeaii aiaeic anueiai iaoa?iaeo uiaei ?aaeiiiioiieiai/ieo
ai?iiiaeueieo oa iioiieiai/ieo aeineiaeaeaiue, ?ic?iaeaii nenoaio
aeiaaiinoe/ieo oa aeeniaina?ieo caoiaeia, ni?yiiaaieo ia iiaeaeuaiiy
aoaeoeaiinoi aeiaaiinoeee oe?ai?aeieo caoai?thaaiue. Ia oei caeiaooeo
?acoeueoaoia cai?iiiiiaaii iiai iaoiaaiaoe/ii iaoaiicie aeieeiaiiy oa
ia?aaiao ie?aieo oe?ai?aeieo caoai?thaaiue, aenoiooi iiai aiiioace uiaei
aeieeiaiiy ?aaeiaoeieii iaoiiaeaii? iaoieiai? ueoiaeaeii? caeice i
iiaeeeainoae ?icaeoeo oe?ai?aeiiai ?aeo a o/anieeia EIA ia *AAN.

Ai?iaaaeaeaiiy ?acoeueoaoia aeineiaeaeaiiy.

?ic?iaeaii i?aeoe/ii ?aeiiaiaeaoei? uiaei canoinoaaiiy i?iiaiaaeo in
vitro oa in vivo iaoiaeia aeiaaiinoeee aiaieuaaeo oe?ai?aeieo
caoai?thaaiue oa noaie aeeniaina?iiai iaaeyaeo ca iniaaie-o/anieeaie EIA
c oe?ai?aeiith iaoieiai?th aeei?enoiaothoueny a aeeniaina?ao
?aaeiaoeieiiai caoenoo a iaeanoyo Oe?a?ie, o aiaeaeieaiii i?ioieaeoeee i
oa?aii? i?iiaiaai? iaoieiai? Oa?eianueeiai IAeI iaaee/ii? ?aaeiieiai?
ii. N.I.A?eai?’?aa, a Oa?eianueeiio iaeaniiio iieieiai/iiio aeeniaina?i,
o eeiiioei Oa?eianueeiai IAeI oa?iaeioa?aii? aiaeie?eiieo caoai?thaaiue,
o Oa?eianueeiio iinueeiio aiaeie?eiieiai/iiio aeeniaina?i. Caeiaooi
?acoeueoaoe, ui iathoue oai?aoe/ia cia/aiiy, aeei?enoiaothoueny i?e
/eoaiii eo?no eaeoeie o Oa?eianueeiio aea?aeaaiiio iaaee/iiio
oiiaa?neoaoi, Oa?eianueeiio iinoeoooi oaeineiiaeaiiy eiea?ia. Iniiaii
?acoeueoaoe aeineiaeaeaiue aeeeaaeaii o 46 iaoeiaeo i?aoeyo. Aeaeaii 3
iioi?iaoeieieo eenoe: ? 137-97 “Iaoiae aeiaaiinoeee oe?ai?aeieo
caoai?thaaiue”; ? 138-97 “Noaia aeeniaina?iiai iaaeyaeo ca iniaaie c
oe?ai?aeiith iaoieiai?th”; ? 139-97 “Iaoiae eiiieaenii? oa?aii? oai?eo c
oe?ai?aeiith iaoieiai?th”. Io?eiaii ?ioaiiy i?i aeaea/o iaoaioo ia
ei?enio iiaeaeue ? 98084257/E aiae 16.02.1999 “I?eno?ie aeey
anii?aoeieii? oiieiaieeiai? ioieoeieii? aiiini?”.

Ai?iaaoeiy ?iaioe.

Iaoa?iaee aeena?oaoei? aeiiiaiaeaeeny i iaaiai?thaaeeny ia:
?anioaeieainueeiio naiiia?i “No/anii iaoiaee aeiaaiinoeee oa eieoaaiiy
oai?ia ueoiaeaeii? caeice”, o?aaaiue 1992 ?., Oa?eia; ?anioaeieainueeie
iaoeiai-i?aeoe/iie eiioa?aioei? “I?iaeaie aeiaaiinoeee oa eieoaaiiy
caoai?thaaiue ueoiaeaeii? caeice”, Oa?eia, eaioaiue 1993 ?.;
Oe?a?inueeie iaoeiai-i?aeoe/iie eiioa?aioei? “Eo/aaay ae?aaiinoeea e
eo/aaay oa?aiey i?ioanneiiaeueiuo e nenoaiiuo caaieaaaiee”, Aeiiaoeuee,
aa?anaiue 1993 ?.; Iiaeia?iaeiie iaoeiai-i?aeoe/iie eiioa?aioei?
“Aeooaeueii ieoaiiy iaaee/ii? ?aaeiieiai? oa iioi?iaoeieieo oaoiieiaie”,
?cia?e, 1994 ?.; V c’?caei aiaeie?eiieiaia Oe?a?ie, eaioaiue 1994 ?.,
Iaaii-O?aieianuee; 9-io ?a?iiaenueeiio eiia?ani ?aaeiieiaia, aa?acaiue
1995 ?., Aiaeaiue, Aano?iy; IV c’?caei iieieiaia Oe?a?ie, aa?anaiue 1995
?., Ee?a; Iaoeiai-i?aeoe/iie eiioa?aioei? “Eiiieaenia aeiaaiinoeea
caoai?thaaiue ueoiaeaeii? caeice, i?aaiia /a?aaii? ii?iaeieie,
cai/a?aaeiiiai i?inoi?o”, eaioaiue 1995 ?., Oa?eia; iioa?iaoeiiiaeueiie
eiioa?aioei? ii ianeiaeeao aaa?i? ia *AAN oa iioeo ?aaeiaoeieieo
aieeaao, eenoiiaae, 1995 ?., AEaiaaa, Oaaeoea?iy; ?anioaeieainueeie
iaoeiai-i?aeoe/iie eiioa?aioei?, o?aaaiue1998 ?., Iaeana;

No?oeoo?a oa ianya aeena?oaoei?.

Aeena?oaoeiy aeeeaaeaia ia 429 noi?iieao iaoeiiieno, neeaaea?oueny ci
anooio, aiaeioe/iiai iaeyaeo eioa?aoo?e, 9 ?icaeieia aeanieo
aeineiaeaeaiue, caeeth/aiiy c iaaiai?aiiyi, aeniiaeia i nieneo
eioa?aoo?e, ui aiiuo? 416 aeaea?ae, c yeeo 376 aio/eciyieo oa 40
iiicaiieo aaoi?ia. Oaeno iethno?iaaii 46 oaaeeoeyie oa 43 ?enoieaie.

CIiNO ?IAIOE

Iaoa?iaee i iaoiaee aeineiaeaeaiue.

Aeey i?iaaaeaiiy ii?iaiyeueiiai aiaeico iniaeeainoae aeieeiaiiy,
?icaeoeo i ia?aaiao caoai?thaaiue ueoiaeaeii? caeice onueiai aoei
ianoaaeaii 1984 o/anieee EIA ia *AAN (c ieo 94 — eiio?ieueia a?oia) oa
1648 iaoeaioeia noiaeo Oe?a?ie (c ieo 50 — eiio?ieueia a?oia) c
oe?ai?aeiith iaoieiai?th (AC, AIO, ?UC) oa AeCUC Ia-II no.

Ianoaaeaii a aeeiaiioei 1986-1997 ??. 555 iaoei?ioia-eieaiaeaoi?ia
ianeiaeeia aaa?i? ia *AAN c o?aaeaiiyi ueoiaeaeii? caeice (465 /ieiaieia
i 90 aeiiie) i 94 /ieiaiee-eieaiaeaoi?e aac oe?ai?aeii? iaoieiai? (79
/ieiaieia i 15 aeiiie). Na?aae ianoaaeaieo c oe?ai?aeiith iaoieiai?th
aoei 166 oai?eo c aooiiioiiei oe?ai?aeeoii (AIO), 101 — c aoceiaei ciaii
(AC), 12 oai?eo ia ?ae ueoiaeaeii? caeice (?UC) oa 276 iaoei?ioia c
aeeoociei caieueoaiiyi ueoiaeaeii? caeice (AeCUC). Aie onio ianoaaeaieo
eieeaaany aiae 20 aei 56 ?ieia. Ianoaaeaii iaie /i?iiaeeueoei ia?aaoaaee
a ciii aaa?i? ia *AAN, ii/eiath/e c ia?oeo oeaeiia iiney aaa?i? i aei
1989 ?ieo. Na?aae iaoei?ioia c oe?ai?aeiith iaoieiai?th 308 inia (68,5%)
ia?aaoaaee a ciii aaa?i? o 1986, ?aooa — 175 (31,5%) — o 1987-1989
?ieao. A eiio?ieueiie a?oii — 79 inia (74%) aoee a ciii aaa?i? o 1986
?., a 24 (26%) o 1987-1989 ?ieao. Na?aaeiy aeica ciaiioiueiai
ii?iiiiaiiy onio o/anieeia EIA 1986 ?ieo noaiiaeea: ianoaaeoaaieo a?oi
229,5 iCa, eiio?ieueii? a?oie 245 iCa; eieaiaeaoi?ia aaa?i? 1987-1989
??. ci ciiiaie a ueoiaeaeiie caeici — 89 iCa, eieaiaeaoi?ia eiio?ieueii?
a?oie 88,5 iCa.

Ia?aeaeueii ianoaaeaii 1042 iaoeaioei noiaeiiai ?aaiiio Oe?a?ie c
aiaeiai/ieie ciiiaie a ueoiaeaeiie caeici: 174 iaoei?ioe c AIO, 173
oai?eo ia AC, 46 iaoei?ioia c ?UC i 649 inia c AeCUC Ia-II no. oaeiai ae
naiiai aieo, ui e iaoei?ioe aeineiaeaeoaaieo a?oi. C ianoaaeaieo aoei
439 aeiiie i 603 /ieiaiee. E?ii oiai, aoei ianoaaeaii 50 i?aeoe/ii
caei?iaeo iaoeaioeia noiaeo Oe?a?ie (20 aeiiie i 30 /ieiaieia oaeiai ae
aieo).

Aiaeic /anoioe aeeoocii? oa aiaieuaai? oe?ai?aeii? iaoieiai? i oa?iiie
?? aeieeiaiiy a caeaaeiinoi aiae /ano ia?aaoaaiiy a ciii *AAN oa aiae
/ano aaa?i? aoei aea/aii na?aae 1336 o/anieeia EIA (48 aeiiie i 1288
/ieiaieia aieii aiae 26 aei 58 ?ieia), ui i?aoethaaee a ciii aaa?i? c
ia?oeo iinyoeia iiney aaa?i? i aei 1989 ?. aeeth/ii. A caeaaeiinoi aiae
oa?iiiia ia?aaoaaiiy a ciii aaa?i? iaie aoei noi?iiaaii 4 a?oie: 1 a?oia
(“eiaeiee” ia?iiae) — c iiiaioii caaa?oaiiy ia?aaoaaiiy a ciii aaa?i? 30
eeiiy 1986 ?ieo (334 iniae); 2 a?oia — aei 31 a?oaeiy 1986 ?. (583
iniae); 3 a?oia — oi, ooi i?aoethaaa a ciii aaa?i? o 1987 ?ioei (282
iniae) i 4 a?oia — ooi aoa o ciii *AAN o 1988-1989 ?ieao (137 inia).

Aiaeiai/ia aeineiaeaeaiiy aoei i?iaaaeaii na?aae 556 iaoeaioeia noiaeo
Oe?a?ie (354 /ieiaieia i 202 aeiiie aieii aiae 20 aei 56 ?ieia).
C’yniaoaaeinue, ye i a o/anieeia EIA ia *AAN, 3 eaoaai?i? ieoaiue: 1 —
aiaenooiinoue ciii a ueoiaeaeiie caeici, 2 — iayaiinoue aeeoociiai
caieueoaiiy ueoiaeaeii? caeice, 3 — iayaiinoue aiaieuaaeo ooai?aiue.
Aeineiaeaeaiiy aaeinue i?ioyaii 1990-1993 ?ieia. O 1990 ?ioei, aoei
iaeyiooi 73 iniae (7 /ieiaieia i 66 aeiiie); o 1991 ?ioei — 54 (24
/ieiaiee i 30 aeiiie); o 1992 ?ioei — 98 inia (16 /ieiaieia i 82 aeiiee)
i a 1993 ?ioei — 331 iniaa (307 /ieiaieia i 24 aeiiee).

Eeiiiei-iino?oiaioaeueia ianoaaeaiiy iaoei?ioia i?iaiaeeeinue ca
?aeeiith i?ia?aiith i aeeth/aei eeiii/ii, iino?oiaioaeueii oa
eaai?aoi?ii aeineiaeaeaiiy.

?icii?e ueoiaeaeii? caeice i?e iaeueiaoei? aecia/aee ca eeaneoieaoei?th
AIIC (1981). Oeueo?acaoeiaa aeineiaeaeaiiy i?iaiaeeeinue ia aia?aoao
SAL-77-”Oioeaa” (ssiiiiy), ui i?aoeth? a ?aaeueiiio ?aaeeii /ano c
?iai/ith /anoioith 7,5 iAoe oa TI 628A (II?I, Oa?eia) ci neaioth/ei
ciiaeii 7,5 iAoe,

c aeei?enoaiiyi eiiaaenieo aeao/eeia.

Ioieoeieia anii?aoeieia aiiiniy c iaoith aa?eoieaoei? aeiaaiico
i?iaiaeeeanue ioieoeieieie aieeaie iaeiai (22-23 g) i na?aaeiueiai (18
g) aeiaiao?a ca aeiiiiiaith ?ic?iaeaii? iaie ianaaeee ia oi?eoe aeey
noai?aiiy a iueiio iaaaoeaiiai oeneo (iaoaio ? 98084257/E aiae
16.02.1999).

?iaii oe?ai?aeieo ai?iiiia — oe?ieneia (O3), o?eeiaeoe?iiiia (O4),
oe?aio?iiiiai ai?iiio aiiioica (OOA) oa iooeeiieo ia?ea?ia —
oe?aiaeiaoeiio (OA) oa ?aeiai-aia?iiiaeueiiai aioeaaio (?AA) aecia/aee
ca caaaeueiii?eeiyoeie iaoiaeeeaie (A.A. ?acieeia, 1980) c
aeei?enoaiiyi ?aaeiiiioiieiai/ieo iaai?ia oi?i “CEA-IRE-SORIN”
(O?aioeiy); “Byk Mallinckrodt”, Iiia//eia; “Aaei?in”, Aiei?onue.

I?e aeineiaeaeaiii iioiieiai/iiai noaio iaoei?ioia eieueeinoue
O-eiioioeeoia aea/aee ca ?aaeoei?th niiioaiiiai ?icaoeiooai?aiiy c
a?eo?ioeeoaie aa?aia, a A-eeioei — c a?eo?ioeeoaie ieoi (A.I.*a?aae??a,
1976). Iaeie eieueeinoi O-noi?ani?ia i?iaiaeeee ca caaaeueiii?eeiyoith
iaoiaeeeith ii A.Olinescu ic niiaaao. (1987). Ooieoeiiiaeueio
aeoeaiinoue O-eiioioeeoia ioeiithaaee ?aaeiiiao?e/iei iaoiaeii ca
?aaeoei?th aeanoo?ainoi?iaoei? ia iioiaai OAA (A.I.*a?aaea?a, 1976).
Caaaeueii oee?eoethth/i iioiii eiiieaene aecia/aee inaaeaeaiiyi a 3,5%
?ic/eii iieiaoeeaiaeieieth ia niaeo?ioioiiao?i NO-46 (TH.A.A?eiaae/,
A.I.Aeoa?ia, 1981). ?iaaiue iioiiaeiaoeiiia iniiaieo eeania
anoaiiaethaaee ca iaoiaeii Iai/eii c aeei?enoaiiyi ne?iaaoie i?ioe
iioiiaeiaoeiiia ethaeeie ae?iaieoeoaa Ieaeiueiai?iaenueeiai IAeI
aiiaeaiiieiai? oa iie?iaiieiai?; oaaioeeoa?io ooieoeith iaeo?ioieia
ioeiithaaee iaoiaeii caaa?oaiiai oaaioeeoico (A.I.Eoae?yaeoeueeee,
1985). Aioeoiea (AO) aei oe?aiaeiaoeiio (OA) i iie?iniiiiai aioeaaio
(IA) ueoiaeaeii? caeice aecia/aee iioiioa?iaioiei iaoiaeii c
aeei?enoaiiyi noaiaea?oieo iaai?ia (IOA) ae?iaieoeoaa IOIOe “Iiiaaea”,
i. Oa?e?a.

Eeiii/iee iioiieiai/iee aeiaaiic (E.E?aa?, 1990) noaaeee c aeei?enoaiiyi
eeaneoieaoei? Gell oa Coombs ca aeiiiiiaith aenia?oii? nenoaie
aeiaaiinoeee oeiia iioiiiaoieiai/ieo ?aaeoeie, ?ic?iaeaii? a
Oa?eianueeiio IAeI iaaee/ii? ?aaeiieiai? ii. N.I. A?eai?’?aa (O.I.
Iiiianueea ic niiaaao., 1994). Iaoaiici eiai/iiai aeniiaeo aenia?oii?
nenoaie caoaeiaaii ia iniiai Aa?nianueeeo ai?iaiaeiinoae i
i?iaeoeoeieiiai aiaeico.

Aeey aea/aiiy ieoiii? aaae ie?aieo caoai?thaaiue ueoiaeaeii? caeice
na?aae iaoeaioeia noiaeo Oe?a?ie a aeeiaiioei aei- i iineyaaa?ieiiai
ia?iiaeo (1982-1997 ?iee) iaie aoei i?iaiaeiciaaii 1674
iaoiainoieiai/ieo caeeth/aiiy uiaei no?oeoo?e aeaeaeaii? ueoiaeaeii?
caeice aai ?? /anoeie, yei aoee io?eiaii iiney eiinoeueoaoei? o?ueio
iacaeaaeieo aenia?oia-ii?oieiaia.

Aeaeo?iiii-iie?ineiii/ii aeineiaeaeaiiy oeaieie ueoiaeaeii? caeice
i?iaiaeeee ca noaiaea?oiith iaoiaeeeith i aiaeicoaaee ca aeiiiiiaith
aeaeo?iiiiai iie?ineiia AI-125 Noinueeiai AI “Aeaeo?ii” i?e
i?enei?thth/ie iai?oci 75 eA.

Noaoenoe/io ia?iaeo ?acoeueoaoia i?iaiaeeee ia AII aiaeiiaiaeieie
i?ia?aiaie aeey iaoaiaoe/iiai aiaeico c aeei?enoaiiyi noaiaea?oiiai
e?eoa?ith Oioa?a-Nouethaeaioa.

Iaoaiaoe/ii aeaii uiaei /ano aeieeiaiiy oe?ai?aeii? iaoieiai?, a
caeaaeiinoi aiae /ano ia?aaoaaiiy a ciii *AAN, ia?iaeyee ia IBM PC/AT ca
aeiiiiiaith i?ia?aie aiaeico oeaico?iaaieo aeai?ie, ?ic?iaeaii? a
OIAeII? ii. N.I. A?eai?’?aa niieueii c eaoaae?ith i?eeeaaeii? iaoaiaoeee
Naieo-Iaoa?ao?cueeiai oaoii/iiai oiiaa?neoaoo. Iiiai?iinoue aiaenooiinoi
iaoieiai? ioeiithaaee ia?aiao?e/iei iaoiaeii Eaieaia-Iae??a, aeai?ee
ii?iaithaaee ca iiaeeoieiaaiei e?eoa?i?i Eieiiai?iaa-Nie?iiaa (1988).

?acoeueoaoe aeineiaeaeaiue oa ?o iaaiai?aiiy.

1. Aeieeiaiiy oa ia?aaia oe?ai?aeii? iaoieiai? a inia, ui a?aee o/anoue
o eieaiaeaoei? ianeiaeeia aaa?i? ia *i?iiaeeuenueeie AAN.

*a?ac 7 ?ieia iiney aaa?i? ia *AAN /anoinoue aeeoociiai caieueoaiiy
ueoiaeaeii? caeice Ia-II no. i aiaieuaaeo o?aaeaiue na?aae o/anieeia
eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN c?inee aiaeiiaiaeii aei 60% i 6%
i?ioe 4% aiaeiai/iiai oe?ai?aeiiai noaio o ianaeaiiy noiaeo Oe?a?ie a
aeiaaa?ieiee ia?iiae (1984). Oaea c?inoaiiy o?aaeaiue ueoiaeaeii? caeice
aoei caoieniaaii ye o eieaiaeaoi?ia “eiaeiiai”, oae i “iaeiaeiiai”
ia?iiaeo.

?acoeueoaoe iiiioi?eiao ?aaeiaoeieii? ianoaiiaee, i?iaaaeaiiai a
Oa?eianueeie iaeanoi i a i. Oa?eia? Oa?eianueeei oiceei-oaoii/iei
iinoeoooii, aeathoue iiaenoaae i?eionoeoe, ui eieaiaeaoi?e — iaoeaioei
Oa?eiaa oa iaeanoi, ia iiaee aeinoaoe ia oeie oa?eoi?i? nooo?ai?, c
oi/ee ci?o ?aaeiaoeieii? iaaeeoeeie, aeice ii?iiiiaiiy, a iniiaieo aeic
caciaee a ia?iiae ia?aaoaaiiy a ciii aaa?i?. Aea o?aaa iiaee?aneeoe, ui
ca ?acoeueoaoaie oeueiai iiiioi?eiao (c 30 eaioiy aei 30 o?aaiy)
iaeneiaeueia ia’?iia aeoeaiinoue 131I neeaaeaea 33,8 Ae/i3 i?e
aeiionoeiie eiai eiioeaio?aoei? o iiaio?i ca aeaieie I?AO-97-4,0 Ae/i3,
oiaoi o 8,5 ?aco ia?aaeuoaaea eiio?ieueiee ?iaaiue (A.I.Aioueei ic
niiaaao., 1990; I?A-97, 1997).

Iaie aoei i?iaiaeiciaaii oa?iiie aeieeiaiiy aeeoocii? (AeCUC Ia-II no.)
oa aoceiai? oe?ai?aeii? iaoieiai? o 1336 o/anieeia EIA ia *AAN a
caeaaeiinoi aiae oa?iiiia ia?aaoaaiiy a ciii aaa?i?. *an ii/aoeo
?icaeoeo oe?aiiaoie aiaeiineany ia iiiaio caaa?oaiiy ia?aaoaaiiy a ciii
aaa?i?, aeaii o a?oiao 1-4 aoee oeaico?iaaii ni?aaa, oiaoi ia /an
ianoaaeaiiy, aai oienoaaeany iaoieiaiy ueoiaeaeii? caeice, aai
i?eeiaeiny, ui oa?iii aei iiiaioo aeyaeaiiy iiaeeeaeo ciii aieueoee aiae
iiia?aaeiueiai ia?iiaeo. Na?aaeiy aeica ciaiioiueiai ii?iiiiaiiy o
a?oiao 1-4 ciaiooaaeanue aiae 210,1±5 iCa aei 58±5 iCa. Caiaeii c oeei
i?e?iaeii aoei a i/ieoaaoe caieueoaiiy /anoioe oe?ai?aeii? iaoieiai? a
inia “eiaeiiai” ia?iiaeo (a?. 1) c iineiaeiaiei cieaeaiiyi oeueiai
iieacieea o iai?yieo a?oie 4 (ia?aaoaaiiy ia *AAN o 1988-1989 ??.). Aea
caeiaooi iaie ?acoeueoaoe (?en. 1, 2) naiae/aoue i?i oa, ui oe?aiiaoi?
aeieeathoue ?aiioa a oeo a?oiao, yei ia?aaoaaee a ciii aaa?i? ia *AAN o
aieueo aiaeaeaeaii oa?iiie — na?aaeiie /an aeyaeaiiy oe?ai?aeii?
iaoieiai? o a?oii 3 — 39,1 iin., a o a?oii 1 — 52,1 iin., ui ?
ia?aaeienaeueiei.

Ioaea, /an ia?aaoaaiiy a ciii *AAN ia aoa ae?ioaeueiei /eiieeii aieeao
ia oa?iii aeieeiaiiy oe?ai?aeii? iaoieiai?. Iaie aoei aenoiooi iioo
aiiioaco — aeeiaiiea ?icaeoeo iaoieiai? ueoiaeaeii? caeice a o/anieeia
EIA, yei iaoeathoue o i. Oa?eiai oa Oa?eianueeie iaeanoi, aecia/a?oueny
iiaeiyie, ui noaeeny aiae?aco iiney aaa?i?, oiaoi aei ?o ia?aaoaaiiy a
ciii *AAN. Oaeith iiaei?th iia aooe iiaeaeuaiee ?iaaiue ia’?iii?
aeoeaiinoi 131I o iiaio?i, ui aoei caoieniaaii o aeaiiio ?aaiiii aaea 30
eaioiy 1986 ?ieo. Aeey ia?aai?ee oeueiai i?eiouaiiy iayaii oeaico?iaaii
aeaii aoei ia?a?aoiaaii aaciina?aaeiuei aiae iiiaioo aaa?i?. Caiaeii c
oaeei iiaeoiaeii anoaiiaeaii (?en. 3, 4), ui aeeiaiiea aeieeiaiiy
oe?ai?aeii? iaoieiai? a onio ianoaaeaieo a?oiao iaeaioe/ia. Na?aaeiie
/an aeieeiaiiy oe?ai?aeii? iaoieiai? a a?oii 1 neeaaea? 53,7±0,14 iin.,
a a a?oii 3 — 53,8±0,019 iin. (ii?iaiyii a?oie, ui iaeaieueo
aiae?iciythoueny ca oiia ia?aaoaaiiy a ciii ?aaeiaoeieii? aaa?i?).
Ia’?aeiaiiy a?oi 1-4 a ?aeeio ianyaii 1336 niinoa?aaeaiue aea? na?aaeiie
/an aeieeiaiiy ciii a ueoiaeaeiie caeici, ui aei?iaith? 53,8±0,001 iin.
Oea naiae/eoue i?i oa, ui ani niinoa?aaeaiiy noinothoueny iaeii??
aaia?aeueii? noeoiiinoi. Aiaeiai/ii caeiiiii?iinoi aeyaeaii i uiaei /ano
aeieeiaiiy o eieaiaeaoi?ia aaa?i? aoceiaeo ooai?ia a ueoiaeaeiie caeici.

Aeeiaiieo oe?ai?aeii? iaoieiai? na?aae o/anieeia EIA ia *AAN iaie
i?inoaaeaii o 1989-1991 ??. (192 iaoei?ioe) i 1992-1994 ??. (117
iaoei?ioia). Aoei aecia/aii, ui na?aae ianoaaeaieo iaeaieueo iioe?aiei
noaiii ueoiaeaeii? caeice ? ?? aeeoocia caieueoaiiy Ia-II no., i?e/iio c
?ieaie i?inoaaeo?oueny oaiaeaioeiy aei cieaeaiiy eiai /anoioe o 1,5
?aco: c 54% na?aae 192 iaoei?ioia, ianoaaeaieo o 1989-1991 ??., aei 37%
— na?aae 117 ianoaaeaieo o 1992-1994 ??. O 2,2 ?aco caieueoeeanue
eieueeinoue iaoei?ioia c AIO (c 13% aei 30%). Eieueeinoue oai?eo c
aoceiaei ciaii eeoa?oueny noaaieueiith —

18 i 20% o aeineiaeaeoaaiee a?ae??cie /ano. Iniaeeao oaaao o?aaa
caa?iooe ia 12 aeiaaeeia oe?ai?aeiiai ?aeo na?aae eieaiaeaoi?ia
aaa?i?. O?e /aa?oi oeeo oai?eo i?aoethaaee a ciii *AAN o 1986 ?ioei,
a iiiaae iieiaeia c ieo — o “eiaeiee” ia?iiae. Ia?aaaaeiith
ii?oieiai/iith oi?iith aoa iaiiey?iee ?ae. O?aoeia o/anieeia EIA, oai?eo
ia oe?ai?aeiee ?ae, i?ioyaii 1-2 ?ieia niinoa?iaaeany ca iinoeai
i?iaeeaaiiy c i?eaiaeo aiia?ieaci? ueoiaeaeii? caeice. Aeiaaiic
oe?ai?aeiiai ?aeo aoei anoaiiaeaii /a?ac 51 iin. iiney caeii/aiiy ?iaio
a ciii *AAN.

Ia aeiiia?aoeieiiio aoaii aeiaaiic ?UC aoei aecia/aii eeoa o iaeii??
iaoei?ioee c 12 oai?eo, a iiney ii?oieiai/iiai aeineiaeaeaiiy
aeeo/aii? oe?ai?aeii? oeaieie — eeoa o 5 iaoei?ioia, o ?aooe (6 oai?eo)
— a OIAeII? iiney eiinoeueoaoei? ainoieiai/ieo i?aia?aoia.

Ioaea, /eiieeii aeieeiaiiy oe?ai?aeii? iaoieiai? a o/anieeia EIA ia *AAN
aoee, i/aaeaeii, aaa?iy oa ?? ianeiaeee, aeiy yeeo i?inoyaeany ia
aeineoue aiaeaeaeaii aiae ai?oeaio?o aaa?i? ?aaiiie Oe?a?ie.

*a?ac 7-8 ?ieia iiney aaa?i? ia *i?iiaeeuenueeie AAN /anoinoue
aeeoociiai caieueoaiiy ueoiaeaeii? caeice Ia-II no. a o/anieeia
eieaiaeaoei? ?? ianeiaeeia caieueoeeany o 15 ?acia, ii?iaiyii c
aeiaaa?iiei /anii. Caciaa ciii i aanue niaeo? oe?ai?aeii? iaoieiai?, ui
aeieeea o oeeo iaoei?ioia: iniiaiith ? aeeoocia caieueoaiiy ueoiaeaeii?
caeice Ia-II no., eieueeinoue yeiai c /anii ciaioo?oueny, aianeiaeie
/iai, i/aaeaeii, c?inoa? ieoiia aaaa aooiiioiiiai oe?ai?aeeoo, o?ao?
iinoea iiniaea? aoceiaee cia. Ia oei AeCUC iiaea ia oieueee ?icaeaaoeny
oaea ia?aaeiooeeiia iaoieiaiy, ye AIO oa AC, ? i iiaeoaa?aeaeaii oaeoe
aeieeiaiiy oe?ai?aeiiai ?aeo a o/anieeia EIA.

2. Iniaeeainoi caoai?thaaiue ueoiaeaeii? caeice o iaoeaioeia noiaeo
Oe?a?ie a no/anieo oiiaao.

Aeey ii?iaiyiiy ?iciianthaeaeaiinoi aeeoocii? oa aiaieuaai? oe?ai?aeii?
iaoieiai? o eieaiaeaoi?ia ianeiaeeia aaa?i? iaie ianoaaeaii 556
iaoeaioeia noiaeo Oe?a?ie, ui ia ae?aeaeaeaee aei ciie *AAN. Oae, o 329
inia c 556 (59%) aiaecia/aeanue iayaiinoue caieueoaiiy ?icii?ia
ueoiaeaeii? caeice c ii?ooaiiyie ?? eiinenoaioei?. Aiaieuaaa oe?ai?aeia
iaoieiaiy aoea caoieniaaia o 42 (7,5%) c 556 ianoaaeaieo, ui ia
aiae?iciyeiny aiae aiaeiai/ieo iieacieeia a o/anieeia EIA ia *AAN
(60% i 6%).

Eieueeinia oa yeinia aeeiaiiea ciii oe?ai?aeii? iaoieiai? o ianaeaiiy
noiaeo Oe?a?ie aoea i?inoaaeaia c 1982 ii 1997 ?. ia oei aiaeico 1674
caeeth/aiue ca ii?oieiai/iei aiaeicii oe?ai?aeii? oeaieie, aeaeaeaii?
iiae /an oi?o?ai/ieo ao?o/aiue o OIAeII?. Eieueeinoue oi?o?ai/ieo
ao?o/aiue c i?eaiaeo aeia?iyeinii? i ceiyeinii? oe?ai?aeii? iaoieiai?
c?inoa? ia?aeaeueii i o 1997 ?ioei (ii?iaiyii c 1982 ?ieii) iiaeaeueeany
aeey ceiyeinieo caoai?thaaiue o 2,4 ?aco, a aeey aeia?iyeinii?
iaoieiai? — o 3,5 ?aco. Ca oaiiaie c?inoaiiy oi?o?ai/ieo ao?o/aiue
c i?eaiaeo aeia?iyeinii? oe?ai?aeii? iaoieiai? — o 3,5 ?aco. Ca
oaiiaie c?inoaiiy oi?o?ai/ieo ao?o/aiue c i?eaiaeo aeia?iyeinii?
oe?ai?aeii? iaoieiai? (ii?iaiyii c 982 ?.) ia?oa iinoea iiniaeathoue
aaeaiiie ueoiaeaeii? caeice (caieueoaiiy o 3,9 ?aco), ia ae?oaiio — AIO
— (c?in o 3 ?ace), ia o?aoueiio — aoceiaee, einoiciee oa ci?oaiee
cia.

Na?aae ceiyeinieo iooeei ueoiaeaeii? caeice ye o aeiaaa?ieii /ane, oae i
iiney aaa?i? ia *AAN ia?aaaaeaa iaiiey?iee ?ae (oaea ia?aaaaeaiiy
i?inoaaeoaaeinue i?ioyaii onueiai /ano aac aeeiaiiee. Ieoiia aaaa
oieieoey?iiai ?aeo iinooiiai caieueooaaeany i — ii?iaiyii c ia?iiaeii
1982-1986 ??. eiai aiaeiinia eieueeinoue o 1992-1997 ??. c?inea o 1,8
?aco. Iaeaea iaciiiaiei aoa aianie iaaeoey?iiai i
iecueeiaeeoa?aioeieiaaiiai oe?ai?aeiiai ?aeo.

Aiaeic /anoioe cono?i/aeueiinoi ii?aeiaiiy oe?ai?aeiiai ?aeo ic ciaii
Oaoeiioi naiae/eoue, ui ii?iaiyii c 1982-1986 ??., o 1987-1991 ??.
Ii?aeiaia iaoieiaiy c?inea o 2 ?ace, a oe?ai?aeiee ?ae — o 1,42 ?aco.
Ca ianooiii 6 ?ieia (1992-1997 ??.) i?e caieueoaiii aeiaaeeia
oe?ai?aeiiai iaiiey?iiai i oieieoey?iiai ?aeo o 1,98 ?aco, ?ae Oaoeiioi
(aai ?acii c iei) c?in o 3,5 ?aco. Ioaea, aooiiioiia oe?ai?aeia
iaoieiaiy ii?iaiyii c aeiaaa?ieiei ia?iiaeii c?inoa? oaeaeoa, iiae
ceiyeinia.

3. Oa?aeoa?enoeea oe?ai?aeiiai ai?iiiaeueiiai noaio, oe?aio?iiii?
ooieoei? aiiioica i ?iaiia iooeeiieo ia?ea?ia a o/anieeia EIA ia *AAN
i?e caoai?thaaiiyo ueoiaeaeii? caeice.

?iaii oe?ai?aeieo ai?iiiia (O3, O4), OOA oa iooeeiieo ia?ea?ia aoei
aeineiaeaeaii o 129 inia (15 aeiiie i 114 /ieiaieia) c aeeoociei
caieueoaiiyi ueoiaeaeii? caeice Ia-II no. 74% ianoaaeaieo (95
inia) a?aee o/anoue o eieaiaeaoei? ianeiaeeia aaa?i? a 1986 ?ioei,
?aooa — 26% o 1987-1989 ??. Na?aaeiy aeica ii?iiiiaiiy eieaiaeaoi?ia
1986 ?ieo c AeCUC noaiiaeea 215±5,61 iCa, 1987-1989 ??. — 71±12 iCa.
Aeiaaiic AeCUC aoei anoaiiaeaii /a?ac 4,3±0,19 ?ieo iiney caaa?oaiiy
?iaio a ciii aaa?i?. Aeineiaeaeaiiy ?iaiia O3, O4, OOA, OA oa ?AA
i?iaaaeaii ye aei, oae i ia iiiaio aecia/aiiy aeiaaiico, a iaaeaei — a
aeeiaiioei 8-?i/iiai niinoa?aaeaiiy.

I?e ianoaaeaiii a?oie inia c AeCUC anoaiiaeaii, ui aiia ia aoea
iaeii?iaeiith ca ?iaiai aeineiaeaeoaaieo ia?aiao?ia.

I?e aecia/aiii na?aaeiio ?iaiia oe?ai?aeieo ai?iiiia ?o niiaaiaeiioaiiy,
aiinoo OOA oa iooeeiieo ia?ea?ia a o/anieeia EIA c AeCUC Ia-II no.
anoaiiaeaii (oaae. 1), ui aiae iieacieeia eiio?ieueii? a?oie 1987 ?. oa
/i?iiaeeueoeia aac ciii a ueoiaeaeiie caeici ai?iaiaeii aiae?iciyeenue
eeoa aiino OA (iiaeaeuaiee aiaeiiaiaeii o 1,6 i 1,7 ?aco) oa ?AA
(iiaeaeuaiee o 2,2 i 2,1 ?aco aiaeiiaiaeii), a ?iaaiue OOA
ai?iaiaeii(P<0,01) aoa ieae/ei, iiae o i?aeoe/ii caei?iaeo inia. Na?aae onio ianoaaeaieo ii?iaeueii ?iaii O3 caoieniaaii o 64% aeiaaeeao, iiaeaeuaii - o 20% i cieaeaii - o 16%. Ii?iaeueiee aiino O4 niinoa?iaaany o 54% ianoaaeaieo, iiaeaeuaiee - o 19%, a cieaeaiee - o 27%. Aiaeiai/ii ?iciiaeieyeeny i iieacieee niiaaiaeiioaiiy oe?ai?aeieo ai?iiiia: ii?iaeueii, iiaeaeuaii i cieaeaii oienoaaeeny o 50%, 25% i 25% ianoaaeaieo aiaeiiaiaeii. Ioaea, uiiaeiaioa o 50% ianoaaeaieo o/anieeia EIA c AeUC Ia-IIco. aiino O3, O4 oa ?o niiaaiaeiioaiiy aoee ii?iaeueieie. Ui ae aei ?iaiy OOA, oi c iaeiaeiaith /anoioith cono?i/aeenue ye ii?iaeueii, oae i cieaeaiii iieacieee - 45%, a iiaeaeuaii - eeoa o 10% ianoaaeaieo. Ii?iaeueii ?iaii OA i ?AA iaee iinoea o 34% i 7% iaoei?ioia, cieaeaii - o 20% i 27%, oiaei ye ia?aaaaeaee iniae c ?o iiaeaeuaiei ?iaiai - 46% i 66% aiaeiiaiaeii. Oaeei /eiii, aeeoocia caieueoaiiy ueoiaeaeii? caeice Ia-II no. a o/anieeia EIA a iieiaeii aeiaaeeia noi?iaiaeaeo?oueny a?aeoeeaiiyie iieacieeia aiinoo oe?ai?aeieo ai?iiiia, oei aea /anii o 45% i?inoaaeo?oueny ai?iaiaeia cieaeaiiy ?iaiy OOA, a o 46-66% - iiaeaeuaiiy ?iaiia iooeeiieo ia?ea?ia. A o/anieeia EIA aac oe?ai?aeii? iaoieiai? o?enoaaeiny eeoa iacia/ia, aea ai?iaiaeia(P<0,05) iiaeaeuaiiy aiinoo O4, yea, iiaeeeai, ia? i?enoinoaaeueiee oa?aeoa?. Oe?ai?aeiee ai?iiiaeueiee noai, aiino OOA oa iooeeiieo ia?ea?ia aoei aeineiaeaeaii o 105 oai?eo - o/anieeia EIA c AIO (12 aeiiie i 93 /ieiaiee). C ieo 65 iaee aeeoocio oi?io caoai?thaaiiy i 40 aeeoocii-aoceiao. Na?aae oai?eo c AIO aeeoociith oi?iith 39 (60%) inia aoee a ciii aaa?i? o 1986?. (na?aaeiy aeica ii?iiiiaiiy 223±72 iCa), a 26 - (40%) - o 1987-1990 ??. (na?aaeiy aeica ii?iiiiaiiy 62±83 iCa). Na?aae iaoei?ioia ic aeeoocii-aoceiaith oi?iith AIO 32 (80%) ia?aaoaaee a ciii aaa?i? o 1986 ?. (na?aaeiy aeica ciaiioiueiai ii?iiiiaiiy - 211±7 iCa) i eeoa 8 oai?eo (20%) - o 1987-88 ??. (na?aaeiy aeica ciaiioiueiai ii?iiiiaiiy 54±8 iCa). Aiaeic na?aaeiio ?iaiia aeineiaeaeoaaieo iieacieeia o oai?eo - o/anieeia EIA c aeeoociith oi?iith AIO (oaae. 1) naiae/ea i?i ai?iaiaeia (P<0,001) cieaeaiiy aiinoo O4 ii?iaiyii c iaoei?ioaie aac oe?ai?aeii? iaoieiai? i?e ii?iaeueieo ?iaiyo O3, aianeiaeie /iai ii?oooaaeiny niiaaiaeiioaiiy oe?ai?aeieo ai?iiiia o aie iiaeaeuaiiy. I?eaa?oa? aei naaa oaaao cia/ia (P<0,001) cieaeaiiy ?iaiy OOA - o 2 ?ace, ii?iaiyii c iaiia eiio?ieyie. C iooeeiieo ia?ea?ia aoa iiaeaeuaiee eeoa aiino ?AA - o 2,6 ?aco, ii?iaiyii c iaiia eiio?ieyie. O oai?eo c aeeoocii-aoceiaith oi?iith AIO oaeiae iaei iinoea ai?iaiaeia (P<0,001) cieaeaiiy ?iaiy O4, ii?ooaiiy niiaaiaeiioaiiy oe?ai?aeieo ai?iiiia i?e noaaieueiiio aiinoi OOA. O oeeo iaoei?ioia aiaeaoaaeinue ia?aeaeueia iiaeaeuaiiy aiaeiiaiaeii o 4 i 3 ?ace ?iaiia OA oa ?AA. Aiaenooiinoue aiaeoeeaiue na?aaeiueiai ?iaiy O3 o iaoei?ioia c iaiia oi?iaie AIO iaoiiaeaia aiaenioeiaei ia?aaaaeaiiyi ii?iaeueiiai eiai aiinoo o 57-58% ianoaaeaieo, oiaei sse o 45% i 40% ianoaaeaieo c aeeoociith i aeeoocii-aoceiaith oi?iaie AIO aiaeiiaiaeii iaei iinoea cieaeaiiy ?iaiia O4. Na?aae oai?eo iaio oeeo a?oi aoei caoieniaaii i cieaeaiiy ?iaiy OOA. Aea eiee o oai?eo c aeeoociith oi?iith AIO oea aoei a 71% aeiaaeeia, oi i?e aeeoocii-aoceiaie - eeoa o 41% ianoaaeaieo ca ii?iaeueieo ?iaiia oe?io?iiiio o 38% iaoei?ioia, ui i iaoiiaeei a inoaiiio aiaenooiinoue aiaeoeeaiue na?aaeiio ?iaiia oeueiai ai?iiio. Aiaenioeiaee ?iciiaeie ii?iaeueieo, iiaeaeuaieo i cieaeaieo iieacieeia OA na?aae iaoei?ioia c aeeoociith oi?iith AIO aoa ?iaiiii?iei, ui iicia/eeiny ia eiai na?aaeiueiio aiinoi (N), oiaei ye ?iaaiue ?AA o ia?aaaaeii? aieueoinoi ianoaaeaieo (64%) aoa cia/ii iiaeaeuaiei. Na?aae iaoei?ioia ic aeeoocii-aoceiaith oi?iith AIO iaeaeaa iooeeiieo ia?ea?e aoee iiaeaeuaii o 76% oai?eo. Oaeei /eiii, ?icaeoie aooiiioiiiai oe?ai?aeeoo a o/anieeia EIA ia *AAN noi?iaiaeaeo?oueny cieaeaiiyi aiinoo O4 i?e noaaieueiiio ?iaii O3; oea aiaeaoaa?oueny ii?yae ci cieaeaiiyi aiinoo OOA (i?e aeeoociie oi?ii AIO), ui noia?a/eoue caeiio “cai?ioiiai” ca'yceo, i yeui cieaeaiiy aiinoo O4 iiaea aiaeaoaaoeny ca ?aooiie eiiaa?ni? eiai a O3 aeey iiaeo?eiee aooe?ai?aeiiai noaio, oi iaeii/ania cieaeaiiy OOA iiynieoe aeineoue aaaeei. Iiaeeeai, oea aiaeaoaa?oueny aianeiaeie o?aaeaiiy aiiioaeaii-aiiioica?ii? nenoaie i?yiith aai iai?yiith ?aaeiaoeieiith aei?th. Aiaeiai/ia aeineiaeaeaiiy aoei i?iaaaeaii i o 42 oai?eo - o/anieeia EIA c aoceiaei ciaii (9 aeiiie i 33 /ieiaiee). A 1986 ?. a ciii aaa?i? i?aoethaaei 23 iniae (55%), ?aooa - 18 inia (45%) a 1987-1989 ??. Na?aaeiy aeica ii?iiiiaiiy oeo, ui i?aoethaaee a ciii aaa?i? o 1986 ?. - 262±57 iCa, a 1987-1989 ??. - 132±21 iCa. Aiaeic na?aaeiio ?iaiia oe?ai?aeieo ai?iiiia (oaae. 1) naiae/eoue i?i iaaia ai?iaiaeia (P<0,02) iiaeaeuaiiy aiinoo O3, ii?iaiyii c eiio?ieai 1987 ?., aea ia c iieacieeaie o/anieeia EIA aac oe?ai?aeii? iaoieiai?. I?e oeueiio aiaeoeeaiue o ?iaiyo O4 caoieniaaii ia aoei. ?acii c oeei aiaecia/aeinue ai?iaiaeia (P<0,01) cieaeaiiy ?iaiy OOA. Oea noi?iaiaeaeoaaeinue iiaeaeuaiiyi o 3 ?ace ?iaiia iaio iooeeiieo ia?ea?ia. Oaei na?aaeii iieacieee aoee coiiaeaii aiaenioeiaei aianeii iiaeaeuaieo aai cieaeaieo ?iaiia aeineiaeaeoaaieo iieacieeia na?aae anio ianoaaeaieo c AC. Oaeei /eiii, na?aae iaoei?ioia o/anieeia EIA c AC naia oae, ye i o oai?eo ia AIO, aiaeaoaaeenue iaeiini?yiiaaii ciiie a nae?aoei? OOA (cieaeaiiy) oa a ?iaiyo iooeeiieo ia?ea?ia (iiaeaeuaiiy) i?e aiaenooiinoi cieaeaiiy O4 i aeayeiio iiaeaeuaiii O3. Ioaea, ciiao o iaoei?ioia-o/anieeia EIA c AC iayaia ii?ooaiiy caeiio “cai?ioii?” ?aaoeyoei? nae?aoei? oe?ai?aeieo ai?iiiia. Cia/iee aianie a ?icoiiiiy caoieniaaieo c?ooaiue oe?ai?aeieo ai?iiiia i OOA aea? aeeiaii/ia niinoa?aaeaiiy ca oeeie iieacieeaie, yea iai aaeaeiny i?iaanoe a o/anieeia EIA ye aac oe?ai?aeii? iaoieiai?, oae c AeCUC i c AIO aeeoociith oi?iith. O?aaa iiaee?aneeoe, ui aeeiaii/ia ianoaaeaiiy iaoei?ioia i?iaaaeaii ua aei aeieeiaiiy o ieo oeo /e iioeo ciii o ueoiaeaeiie caeici, a iiiaio anoaiiaeaiiy aeiaaiico i a iiaeaeueoiio. Ia?oa aeineiaeaeaiiy i?iaaaeaii /a?ac 0,5 ?ieo iiney caeii/aiiy ?iaio a ciii *AAN, ae?oaa - /a?ac 1 ?ie, ?aooa - ui?i/ii (anueiai i?ioyaii 6-9 ?ieia). I?e aeeiaii/iiio aea/aii ?iaiy O3 (?en. 5) a o/anieeia EIA anio aeineiaeaeoaaieo a?oi aoei caoieniaaii eiai aiaeiinio noaaieueiinoue, aea c ai?iaiaeiei iiaeaeuaiiyi o ia?oi ?iee iiney caeii/aiiy ?iaio o ciii aaa?i?. A iiaeaeueoiio aiaeaoaaeany ii?iaeicaoeiy oeueiai iieacieea, yea oo?eioaaeanue aieueo noaaieueii a inia aac oe?ai?aeii? iaoieiai? i iaoei?ioia c AIO i?e i?aaiaiii O3 o inia c AeCUC aei iiaeaeuaiiy iaaioue /a?ac 8 ?ieia iiney caeii/aiiy ?iaio o ciii *AAN. Ia aiaeiiio aiae oeueiai, aeeiaiiea aiinoo O4 caciaea aieueoeo ciii (?en. 5). *a?ac 0,5-3 ?iee o anio ianoaaeaieo iaoei?ioia aiaeaoaaany nieane ?iaiy O4, i?e/iio iaecia/iioee - o oeo, o eiai caiaeii aeiee AIO. Iaaeaei aiaeaoaaeinue cieaeaiiy aiinoo O4 i eiai ii?iaeicaoeiy, i?e/iio oeae i?ioean iaeoaeaeoa ?icaeaaany o iaeaooiio oai?eo ia AIO, aea iioii ia?aoai?eany ia ai?iaiaeia cieaeaiiy ?iaiy O4 aei 5-8 ?ieo aeineiaeaeaiiy. O aeaui iiciioi no?iee (8 ?ie) oaeee aea i?ioean cieaeaiiy O4 iiney eiai nieaneo niinoa?iaaany i o iaoei?ioia ic AeCUC. Oaea aeeiaiiea aiinoo O3 (eiai aiaeiinia noaaieueiinoue i iacia/ia iiaeaeuaiiy) i?e cieaeaiii c /anii, ui ieioa iiney ia?aaoaaiiy a ciii *AAN, ?iaiy O4 o iaoei?ioia c AeCUC i AIO iiaea ?icoeiithaaoenue ye ?icaeoie noaeeiii/ii? oi?ie ia?aeiiiai aiiioe?aico (E.I.?noa?, 1978), yeee, i/aaeaeii, aeieea? aianeiaeie ooeiaeaeoth/i? ?aaeiaoeieii? aei? ia ueoiaeaeio caeico i iineeth?oueny oe?ai?aeiith iaoieiai?th, ui aeieea?. I?e oeueiio i?e?iaeii aoei a i/ieoaaoe ii?iaeueieo aai iiaeaeuaieo ?iaiia OOA, i aeienii, o ia?oi 0,5-1 ?ie iiney ?aaeiaoeieiiai aieeao aiaeaoaaeinue iiaeaeuaiiy aiinoo OOA a o/anieeia EIA, o yeeo caiaeii ?icaeioany AIO oa aeieeaei AeCUC (?en.5). O inoaiiio /a?ac 5-6 ?ieia iiney caeii/aiiy ?iaio o ciii *AAN niinoa?iaaeeny aaea noaaieueii iecueei oeeo?e aiinoo OOA, ii?iaiyii c eiio?ieai. O iaoei?ioia c AIO i?ioean cieaeaiiy ?iaiy OOA ii/aany ?aiioa. Cieaeaii ?iaii OOA oienoaaeeny o oeeo inia aaea /a?ac 2 ?iee iiney caeii/aiiy ?iaio o ciii aaa?i? (/a?ac 4 ?iee o oeeo inia aoei anoaiiaeaii aeiaaiic AIO), oeae i?ioean i?ia?anoaaa aae aei 8-ai ?ieo niinoa?aaeaiiy. A o/anieeia EIA ia *AAN aac oe?ai?aeii? iaoieiai? cieaeaiiy aiinoo OOA aoei iaio ae?aaeaiei, ianoaaaei iiaieueiioa i eiio ia ia?aaeoaaa nieane ?iaiy oeueiai ai?iiio. Oaeei /eiii, ye o iaaii? eieueeinoi o/anieeia EIA c AIO oa AC, oae i o inia c AeCUC ia?aeaeueii c iciaeaie noaeeiii/iiai ia?aeiiiai aiiioe?aico aeieeathoue i eaai?aoi?ii i?iyae o?aaeaiiy aiiioaeaii-aiiioica?ii? noa?e, ui noi?iaiaeaeo?oueny cieaeaiiyi nae?aoei? aiiioica?iiai OOA aianeiaeie, i/aaeaeii, aieeao ciaiioiueiai ii?iiiiaiiy ia aieiaiee iicie i iaeaieueo aaneoey?eciaaio aiiioaeaii-aiiioica?io aeieyieo, iai?yii? ?aaeiaoeieii? aei? oa aieeao no?ani?ieo oaeoi?ia. A yeui a?aooaaoe iinooiiaa i?ia?anoth/a cieaeaiiy aiinoo OOA iaaioue o /anoeie o/anieeia EIA aac oe?ai?aeii? iaoieiai?, oi oey eaoaai?iy iaoei?ioia, iio?aao? niinoa?aaeaiiy. Aei a?oie “?eceeo” iathoue aooe aiaeianaii i oi o/anieee eieaiaeaoei? ?aaeiaoeieii? aaa?i?, o yeeo niinoa?iaa?oueny iiaeaeuaiee ?iaaiue iooeeiieo ia?ea?ia (OA oa ?AA), iniaeeai i?e iayaiinoi aaea inioth/i? oe?ai?aeii? iaoieiai? (AeCUC, AC, AIO aeeoocii-aoceiaa i aeeoocia oi?ia). Aeey canoinoaaiiy o i?aeoe/iie iaaeeoeeii cai?iiiiiaaii aeaeieyoe aeeoocio ? aeeoocii-aoceiao oi?ie AIO ca oiia niiieiai/iiai oa oeeoieiai/iiai iiaeoaa?aeaeaiiy iayaiinoi aiaeiiaiaeieo iciae aooiiioiiiai i?ioeano o ia?aioiii ueoiaeaeii? caeice oa aoceiaiio ooai?aiii. 4. Oe?ai?aeiee ai?iiiaeueiee noai, oe?aio?iiia ooieoeiy aiiioica i ?iaaiue iooeeiieo ia?ea?ia a o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN c AeCUC, AIO oa AC o caeaaeiinoi aiae caeiaooi? aeice ciaiioiueiai ii?iiiiaiiy. Aeey oiai, uia iiaeoaa?aeeoe iaoi i?eiouaiiy i?i iiaeeeainoue aieeao iiiicoaaeueii? ?aaeiaoei? ye ia ueoiaeaeio caeico (aeiciaa iaaaioaaeaiiy aiae ?aaeiiaeoeaiiai eiaeo), oae i ia no?oeoo?e iiceo (aianeiaeie i?yiiai aeenoaioeieiiai aieeao -?aaeiaoei? ia aieiaiee iicie), iaie aea/aia ooieoeiiiaeueia aeoeaiinoue ueoiaeaeii? caeice, oe?aio?iiia ooieoeiy aiiioica oa ?iaii iooeeiieo ia?ea?ia o eieaiaeaoi?ia ianeiaeeia aaa?i? ye aac oe?ai?aeii? iaoieiai?, oae ic AeCUC, AIO oa AC a caeaaeiinoi aiae aeice ciaiioiueiai ii?iiiiaiiy (oaae. 2). I?e eiaeiiio aeaei iaoieiai? ueoiaeaeii? caeice, a oaeiae a inia aac ia? aeineiaeaeaiiy i?iaiaeeee a a?oiao c aeiciaei iaaaioaaeaiiyi, ui noaiiaeei aei 250 iCa aai aoei aieueoei aiae iueiai. O a?oii eieaiaeaoi?ia aaa?i? c AeCUC ?iaii oe?ai?aeieo ai?iiiia, ?o niiaaiaeiioaiiy, OOA, OA oa ?AA a aeiaeiiio aeiaaeeo ia caeaaeaee aiae caeiaooi? aeice ciaiioiueiai ii?iiiiaiiy. O iaoei?ioia c AIO aiino O3 aoa noaaieueiei i ia ciiithaaany a caeaaeiinoi aiae caeiaooi? aeice. Aea aiino oe?ieneio a inia oei?? a?oie c aeicith iiiaae 250 iCa aoa ai?iaiaeii (P<0,001) ieae/ei, iiae o oai?eo c iaioei aeiciaei iaaaioaaeaiiyi. ?iaaiue OOA aoa ieae/ei (P<0,05) i?e aieueoiio aeiciaiio iaaaioaaeaiii, oi/ i a inia c aeicith, iaioith aiae 250 iCa, aoa cia/ii cieaeaiei. ?iaaiue iooeeiieo ia?ea?ia, iiaeaeuaiee acaaaei, ia caeaaeaa aiae aeice ciaiioiueiai ii?iiiiaiiy. Na?aae iaoei?ioia-/i?iiaeeueoeia c aoceiaei ciaii ?icieoey o iiaea?oiao i?inoaaeoaaeanue aieueo nooo?ai. Oae, o oai?eo ia AC ic aeicith ciaiioiueiai ii?iiiiaiiy iiiaae 250 iCa niinoa?iaaeiny ai?iaiaeia (P<0,001) cieaeaiiy O3, iiaeaeuaiiy O4 i cieaeaiiy OOA, ii?iaiyii c a?oiith c iaioei aeiciaei iaaaioaaeaiiyi. ?icaiaeiinoae o ?iaiyo OA oa ?AA a caeaaeiinoi aiae caeiaooi? aeice o iaoei?ioia c AC ia niinoa?iaaeiny. O inia aac oe?ai?aeii? iaoieiai? ia aeyaeaii ai?iaiaeiiai aieeao aeiciaiai iaaaioaaeaiiy ia ?iaii oe?ai?aeieo ai?iiiia. Ii?yae c oeei, oae naii ye i ca iioi? iaoieiai? ueoiaeaeii? caeice (ca aeiyoeii a?oie c AeCUC), o /i?iiaeeueoeia aac ?? o?aaeaiiy aieueoa aeiciaa iaaaioaaeaiiy ii?aeio?oueny c aieueo iecueeei aiinoii OOA, oi/ oeae ona?aaeiaiee iieaciee aoa o iaaeao i?eionoeieo eieeaaiue. Oaeei /eiii, iiaeia aeieoe aeniiaeo, ui caeaaieueoiai c?inoaiiy aeice ciaiioiueiai ii?iiiiaiiy ia oieueee aeaui ciaioo? ie?aii iieacieee oe?ai?aeii? ai?iiiaeueii? aeoeaiinoi o oai?eo c iaoieiai?th ueoiaeaeii? caeice, a e i?eaii/o? ooieoeiiiaeueio aeoeaiinoue aiiioaeaii-aiiioica?ieo oeaio?ia (i?iaeoeoeiy OOA) iaaioue a o/anieeia eieaiaeaoei? ianeiaeeia aaa?i, a yeeo aei oiai /ano ia aeyaeaii aoaeue-yeeo i?aaii/ieo ciii o ueoiaeaeiie caeici. I?i aiaeiai/iee i?eaii/oth/ee aieea iiiicoaaeueiiai aei?iiiiaiiy uiaei iioeo o?iiieo ai?iiiia aiiioica iiaiaeiieythoue aaaaoi aeineiaeieeia (A.A.Aieoeaae/, 1967; I. N.Cicoey i niiaaao. 1993; I.I.Bogoslovsky at al.;1994, A.E.*aaai, 1995). 5. Oa?aeoa?enoeea oe?ai?aeiiai ai?iiiaeueiiai noaio, oe?aio?iiii? ooieoei? aiiioica i ?iaiia iooeeiieo ia?ea?ia i?e caoai?thaaiiyo ueoiaeaeii? caeice o iaoeaioeia noiaeo Oe?a?ie a no/anieo oiiaao. I?ioyaii 1992-1995 ??. iaie aoei ianoaaeaii 237 inia, iaoeaioeia noiaeo Oe?a?ie c aeeoociei caieueoaiiyi ueoiaeaeii? caeice Ia-II no. , o oiio /enei 95 aeiiie i 142 /ieiaiee 20-52 ?ieia. O aeineiaeaeoaaiie a?oii, ia aiaeiiio aiae aiaeiai/ii? a?oie o/anieeia EIA, na?aaeii ?iaii oe?ai?aeieo ai?iiiia, ?o niiaaiaeiioaiiy oa aiino OOA ia aiae?iciyeenue aiae iieacieeia eiio?ieueii? a?oie, ianoaaeaii? a iineyaaa?ieiee ia?iiae. Aeiyoie noaiiaea eeoa ?iaaiue ?AA, yeee iaeaea o 2 ?ace ia?aaeuoaaa eiio?ieueii ?iaii i?e ii?iaeueiiio aiinoi OA, oi/a oey a?oia oaeiae aoea iaiaeii?iaeiith i neeaaeaeany c inia ye c ii?iaeueieie, oae i iiaeaeuaieie oa cieaeaieie ?iaiyie aeineiaeaeoaaieo iieacieeia. Ii?iaeueii iieacieee aiinoo oe?ai?aeieo ai?iiiia cono?i/aeeny o 46-60% ianoaaeaieo, ?iaaiue OOA aoa aieueo noaaieueiei i ia?aaoaaa o iaaeao ii?ie o 75% inia. Aiaeoeeaiiy oeeo iieacieeia o oie /e iioee aie aeyaeaii o 10-35% ianoaaeaieo c AeCUC, i?e/iio yeui eieeaaiiy oe?ai?aeieo ai?iiiia niinoa?iaaeeny o 19-35% iaoei?ioia, oi aiaeoeeaiiy aiinoo OOA - eeoa o 10-14%. Eieeaaiiy ?iaiia iooeeiieo ia?ea?ia caoieniaaii o 30-41% ianoaaeaieo i?e ii?iaeueieo ?o iieacieeao o 24-29%. Aieueo eaaieueiei aoa aiino ?AA (/anoioa - iiaeaeuaiei). Ianoaaeaiiy 174 oai?eo ia AIO (65 aeiiie i 109 /ieiaieia 26-54 ?ieia) naiae/eei, ui na?aaeii ?iaii oe?ai?aeieo ai?iiiia, ?o niiaaiaeiioaiiy i aiino OOA ia aiae?iciyeenue aiae eiio?ieth. Ii?iaeueiei aoa i ?iaaiue OA, oiaei ye ?AA o 3 ?ace ia?aaeuoaaa eiio?ieueii iieacieee. I?e oeueiio aiino O3 aoa noaaieueiioa (ii?iaeueiee o 64% oai?eo), oiaei ye ii?iaeueii ?iaii O4 niinoa?iaaeeny eeoa o 42% iaoei?ioia, a o 41% ianoaaeaieo aii aoa cieaeaiei. Eieeaaiiy O3 o aie cieaeaiiy i iiaeaeuaiiy cono?i/aeiny o iaioi? eieueeinoi oai?eo - 21 i 15% aiaeiiaiaeii. Ii?iaeueii i iiaeaeuaii iieacieee OOA niinoa?iaaeeny o iaeiaeiai? eieueeinoi oai?eo (39%), a cieaeaiiy aiinoo OOA, ui i?inoaaeoaaeinue o 21% iaoei?ioia, aoei ia oaeei cia/iei, ye a o/anieeia EIA c AIO. Ioaea, iaoeaioeyi noiaeo Oe?a?ie c AIO i?eoaiaiii iaio ae?aaeaii iciaee ii?ooaiiy ooieoei? ueoiaeaeii? caeice i?e caa?aaeaiii aeoeaiinoi aeueo ?aaoethaaeueieo oeaio?ia, ia aiaeiiio aiae o/anieeia EIA ia *AAN, o yeeo ia?aaia caoai?thaaiiy noi?iaiaeaeo?oueny aieueo cia/oueie iciaeaie ye cieaeaiiy oe?ai?aeii? ooieoei?, oae i i?eaii/aiiy aeoeaiinoi aiiioaeaii-aiiioica?ii? aeieyiee. Aeey inoaiiio aeanoeaa i ia?aaaaeaiiy iiaeaeuaieo ?iaiia iooeeiieo ia?ea?ia, ii?iaiyii c oai?eie-iaoeaioeyie noiaeo Oe?a?ie. Aiaeiai/ia aeineiaeaeaiiy aoei i?iaaaeaii i o 173 iaoeaioeia noiaeo Oe?a?ie, oai?eo ia aoceiaee cia. Na?aae ianoaaeaieo aoei 105 aeiiie i 68 /ieiaieia aieii 24-56 ?ieia. Aeineiaeaeaiiy, ye i a iiia?aaeiio a?oiao, i?iaaaeaii i?ioyaii 1992-1995 ?ieia. Na?aaeii ?iaii ye oe?ai?aeieo ai?iiiia, oae i OOA aoee a iaaeao ii?ie, oiaei ye aiino OA i ?AA o 3 i 2 ?ace aiaeiiaiaeii ia?aaeuoaaa eiio?ieueii ia?aiao?e. Oea aiae?iciyeinue aiae ?acoeueoaoia, ui niinoa?iaaeenue a o/anieeia EIA c oaeith ae iaoieiai?th ueoiaeaeii? caeice. O inoaiiio aiaecia/aeinue ai?iaiaeia iiaeaeuaiiy aiinoo O3 ii?yae ci cieaeaiiyi na?aaeiio ?iaiia OOA. Uiaei ciii o aiinoi iooeeiieo ia?ea?ia, oi aiie aoee aiaeiai/ieie o iaoeaioeia noiaeo Oe?a?ie i a o/anieeia EIA c AC. Aiaenioeiaee ?iciiaeie ii?iaeueieo, cieaeaieo i iiaeaeuaieo ?iaiia aeineiaeaeoaaieo ia?aiao?ia, ui iaoiiaea icia/aii na?aaeii ?o ?iaii, naiae/eoue i?i ia?aaaaeaiiy (63%) ii?iaeueieo iieacieeia O3 (noaaieueiinoue O3) i cieaeaieo (45%) ?iaiia O4. Inoaii? iiaaethaaeinue ii?iaeueieie (38%) i cieaeaieie (18%) iieacieeaie aiinoo O4. O iieiaeie iaoei?ioia niinoa?iaaeenue i ii?iaeueii iieacieee OOA, a iiaeaeuaii i cieaeaii - oaeai/i ?iaeoa. Ia?aaaaeaiiy iiaeaeuaieo iieacieeia iooeeiieo ia?ea?ia (51% i 38%) iaae /anoioith cieaeaieo ia?aiao?ia (32% i 39%) i coiiaeei iayaiinoue iiaeaeuaieo na?aaeiio ?iaiia OA i ?AA o oai?eo ia AC. Oaeei /eiii, o iaoeaioeia noiaeo Oe?a?ie c AC niinoa?iaa?oueny ii?iaeueiee na?aaeiie ?iaaiue oe?ai?aeieo ai?iiiia i OOA i?e iiaeaeuaieo ?iaiyo iooeeiieo ia?ea?ia. I?ioa o iaaii? eieueeinoi oai?eo i?inoaaeothoueny noaeeiii/ii iciaee ye aiia?-, oae i aiiioe?aico c ia?aaaaeaiiyi inoaiiueiai. Caa?oa? ia naaa oaaao aeeiaiiea ?iaiia oe?ai?aeieo ai?iiiia i OOA o iaoei?ioia Oe?a?ie c AeCUC, AIO oa AC, ui aiaeaeaa? caeiiiii?iinoi, yei aeieeee a no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao. Aeeiaii/ia niinoa?aaeaiiy ca ciiiaie aiinoo O3 i?ioyaii 1992-1995 ??. naiae/eoue i?i iayaiinoue iaeiioeiieo oaeeueiiiaeiaieo eieeaaiue ?iaiy o?eeiaeoe?iiiio i?e anio aeaeao oe?ai?aeii? iaoieiai? oa AeCUC, ui aiaeaoaaeeny a aeiaiaciii, eio?ee aeaui ia?aaeuoaaa eiio?ieueii iieacieee. C /anii oeae ia?aiao? ooieoeiiiaeueii? aeoeaiinoi ueoiaeaeii? caeice o iaoeaioeia noiaeo Oe?a?ie ye c AeCUC, oae i c AIO oa AC iinooiiai ii?iaeicoaaany. Eieeaaiiy ?iaiia O4 o oai?eo ia AIO oa AC aiaeaoaaeiny aeecueei aei eiio?ieueiiai ?iaiy, a o iaoeaioeia Oe?a?ie c AeCUC o 1993, 1994 ??. i?inoaaeoaaeinue ai?iaiaeia iiaeaeuaiiy O4 c ianooiiith eiai ii?iaeicaoei?th o 1995 ?. Uiaei aeeiaii/ieo ciii aiinoo OOA o oeeo iaoei?ioia, oi i?e AeCUC eieeaaiiy iieacieea aoee aiaenooii; o oai?eo ia AIO i?inoaaeoaaeanue ni?yiiaaiinoue aei aeayeiai c?inoaiiy eiai aiinoo, a i?e AC - aiaeiinia noaaieueiinoue. Oaeei /eiii, o iaoeaioeia noiaeo Oe?a?ie c AeCUC, AIO oa AC aeeiaii/ii eieeaaiiy aiinoo oe?ai?aeieo ai?iiiia i OOA naiae/eee i?i caa?aaeaiiy ?aaoeyoi?ieo ca’yceia i aiaeiiaiaeaee cae/aeiiio ia?aaiao caoai?thaaiue ueoiaeaeii? caeice (AIO, AC). 6. Iioiia ?aaeoeaiinoue i?e iaoieiai? ueoiaeaeii? caeice a inia, ui a?aee o/anoue o eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN. Noai iioiieiai/ii? ?aaeoeaiinoi aoei aea/aii o 42 o/anieeia EIA ia *AAN (10 aeiiie i 32 /ieiaieia aieii 23-56 ?ieia) c AeCUC. Ii?iaiyiiy i?iaaaeaii c a?oiith eieaiaeaoi?ia aaa?i? c 48 inia (7 aeiiie i 41 /ieiaie oaeiai ae aieo), ui ia iaee ciii c aieo ueoiaeaeii? caeice, oa i?aeoe/ii caei?iaeie aeiii?aie (51 iniaa). A o/anieeia EIA ia *AAN c AeCUC ia aeiaeaeaii nooo?aeo ciii o eieueeinieo oa ooieoeiiiaeueieo aeanoeainoyo O-eeioeiii? eaiee iioiioaoo ca aeiyoeii ai?iaiaeiiai (?<0,05) ciaioaiiy aiaeiinii? eieueeinoi O-caaaeueieo eiioioeeoia. Anoaiiaeaii iayaiinoue c?ooaiue ia?aaaaeii o aoii?aeueiie eaioei iioiioaoo - ai?iaiaeia (P<0,001) cieaeaiiy aaniethoiiai aiinoo A-eiioioeeoia, iiaeaeuaiiy o 1,8 ?aco oee?eoethth/eo iioiieo eiiieaenia oa cieaeaiiy aeayeeo iieacieeia ianiaoeeoi/iiai caoenoo i?aaiicio (iiaeaen caaa?oaiinoi oaaioeeoico). O?aaa iiaee?aneeoe, ui aiaeiai/ii aiaeoeeaiiy caoieniaaii i a o/anieeia EIA, ui ia iaee ciii o ueoiaeaeiie caeici. I?e aeineiaeaeaiii noaio iioiioaoo o 30 iaoei?ioia (2 aeiiee, 28 /ieiaieia 31-54 ?.) c AIO aeeoociith oi?iith oa 26 oai?eo (3 aeiiee i 23 /ieiaiee oiai ae aieo) c aeeoocii-aoceiaith oi?iith AIO iaie anoaiiaeaii cia/iioi ciiie. O iaoei?ioia c iaiia oi?iaie AIO i?inoaaeoaaeinue eieueeinia cieaeaiiy aiinoo O-caaaeueieo eiioioeeoia (P<0,01), i?eaii/aiiy ooieoeiiiaeueii? aeoeaiinoi O-eiioioeeoia o aiaeiiaiaeue ia OAA o oai?eo ic aeeoociith oi?iith AIO. O oeeo oai?eo aoei ai?iaiaeii (P<0,001) cieaeaii iiaeaen noeioeyoei?. O oie aea /an ii?ooaiue iioiaainoeioeueiaaieo aeanoeainoae O-eiioioeeoia o iaoe??io?a c aeeoocii-aoceiaith oi?iith AIO ia anoaiiaeaii. Ia?aiao?e aoii?aeueii? eaiee iioiioaoo aoei ciiiaii o iaoei?ioia c iaiia oi?iaie AIO. Aea yeui aaniethoiee aiino A-eiioioeeoia a o/anieeia EIA iaio a?oi aoei cieaeaii iacia/iith ii?ith (oi/a i ai?iaiaeii, P<0,01), oi ?iaaiue IgG o iaoei?ioia c aeeoociith oi?iith AIO o 1,5 ?aco ia?aaeuoaaa iieacieee aeiii?ia (ca ii?iaeueieo iieacieeia o eieaiaeaoi?ia eiio?ieueii? a?oie i c aeeoocii-aoceiaith oi?iith AIO). Iaaiaee, aiino OeIE iaeaea o 3 ?ace ia?aaeuoaaa eiio?ieueiee ?iaaiue o iaoei?ioia c aeeoocii-aoceiaith oi?iith AIO. Iieacieee ianiaoeeoi/iiai caoenoo i?aaiicio oaae aoee aieueoith ii?ith cieaeaii I?e aeeoocii-aoceiaie oi?ii AIO. Aiaeic /anoioe aeyaeaiiy aioeoie aei aioeaaiia ueoiaeaeii? caeice naiae/ea i?i iaeaioe/iinoue iaio oi?i AIO ca oeei ia?aiao?ii. Na?aae ia’?aeiaii? a?oie o/anieeia EIA c AIO aioeoiea aei OA o aenieeo oa na?aaeiio oeo?ao aoei aeiaeaeaii o 60% iaoei?ioia, a aei IA - o 82%, ui aoei cia/ii /anoioa, iiae o eieaiaeaoi?ia aaa?i? aac oe?ai?aeii? iaoieiai? - 2% i o iaoei?ioia c AeCUC (AO aei OA i IA o 5% i 7% ianoaaeaieo aiaeiiaiaeii). I?e ianoaaeaiii 34 iaoei?ioia-o/anieeia EIA c AC (2 aeiiee i 32 /ieiaiee 24-53 ?ieia), oae naii, ye i o ianoaaeaieo c AeCUC oa oai?eo ia AIO, aoei ai?iaiaeii cieaeaii (P<0,001) aaniethoio eieueeinoue O-caaaeueieo eiioioeeoia i?e aiaenooiinoi ii?ooaiue iioeo ia?aiao?ia O-eeioeiii? eaiee iioiioaoo oa ooieoeiiiaeueii? aeoeaiinoi O-eiioioeeoia. sse i i?e iioie oe?ai?aeiie iaoieiai? i AeCUC o /i?iiaeeueoeia, aea cia/iioa, o iaoei?ioia c AC aoei cieaeaii aaniethoio eieueeinoue A-eiioioeeoia (o 2 ?ace) i iiaeaeuaii ?iaaiue OeIE (a 1,7 ?aco). C oa?aeoa?enoee ianiaoeeoi/iiai caoenoo i?aaiicio aoei aecia/aii eeoa cieaeaiiy o 1,8 ?aco iieacieea ICO. Aioeoiea aei OA na?aae oei?? a?oie oai?eo aoei aeiaeaeaii o 32%, a aei IA - o 53% ianoaaeaieo. Oea, i/aaeaeii, naiae/eoue i?i i?enooiinoue aeaiaioia aooiiioiiiai i?ioeano o aeayei? /anoeie o/anieeia EIA c AC aai i?i iioiieiai/io niieueiinoue oeeo caoai?thaaiue, ai /anoioo aeyaeaiiy i?aaiiniaoeeoi/ieo aioeoie o oai?eo ia AC iiaeia ii?iaiyoe c eeoa /anoioith i?e AIO. E?ii aiaeico ie?aieo iieacieeia anio eaiie iioiioaoo o iaoei?ioia - o/anieeia EIA ye aac o?aaeaiue ueoiaeaeii? caeice ic AeCUC, oae c AIO oa AC, noai iioiii? nenoaie aoei i?iaiaeiciaaii eiiieaenii c aecia/aiiyi oeiia aiia?naineoeaieo ?aaeoeie. A o/anieeia EIA ia *AAN, ye c AeCUC, oae i aac o?aaeaiue ueoiaeaeii? caeice, ia?aaaaeaee ?aaeoei? iaaaeiiai oeio (64,26% i 70% aiaeiiaiaeii) a oie /an, eiee ?aaeoei? oiiaieueiaiiai oeio (O-eeioeiii-iiina?aaeeiaaii) cono?i/aeeny eeoa o 9,52% i 14% aeiaaeeia aiaeiiaiaeii. Aiaenooiinoue iioiiiaoieiai/ieo ?aaeoeie o iaoei?ioia c AeCUC i aac oe?ai?aeii? iaoieiai? cono?i/aeany eeoa o 26,19% i 16% ianoaaeaieo aiaeiiaiaeii, a oie /an ye o a?oii aeiii?ia iioiiiaoieiai/i? ?aaeoei? acaaaei ia aeiaaiinooaaeeny. A o/anieeia EIA c AIO aoei aeiaeaeaii ?icaiaeiinoi iiae /anoioith i oa?aeoa?ii iioiiiaoieiai/ieo ?aaeoeie i?e aeeoociie oa aeeoocii-aoceiaie eiai oi?iao. Oi/ i?e iaio oi?iao AIO ia?aaaaeaee ?aaeoei? iaaaeiiai oeio, i?e aeeoociie oi?ii caoai?thaaiiy oei ?aaeoei? aeyaeyeeny /anoioa (83,3%), iiae i?e aeeoocii-aoceiaie (57,7%), oi/a i?e iaio oi?iao ia?aaaaeaee ?aaeoei? iioiieiiieaeniiai oeio (56,7% i 46,2%). ?aaeoei? oiiaieueiaiiai oeio (O-eeioeiii-iiina?aaeeiaaii) i?e aeeoocii-aoceiaie oi?ii AIO ia niinoa?iaaeeny acaaaei, a i?e aeeoociie oi?ii - o 10% oai?eo. Aiaenooiinoue iioiiiaoaeiai/ieo ?aaeoeie o oai?eo ic aeeoocii-aoceiaith oi?iith AIO oienoaaeany o 42% iaoei?ioia, a i?e aeeoociie oi?ii AIO - eeoa o 7% oai?eo. O iaoei?ioia c AC oaeiae ia?aaaaeaee iioiiiaoieiai/ii ?aaeoei? iaaaeiiai oeio (70,6%), c ieo - iioiieiiieaenii (53%) - oae naii, ye i ca iioi? oe?ai?aeii? iaoieiai?, i?e AeCUC i a o/anieeia EIA aac caoai?thaaiue ueoiaeaeii? caeice. ?aaeoei? oiiaieueiaiiai oeio cono?i/aeeny eeoa o 5,9% ianoaaeaieo, a aiaenooiinoue iioiiiaoieiai/ieo ?aaeoeie o 24% iaoei?ioia. Oaeei /eiii, a o/anieeia EIA ia *AAN c aeeoociith oa aiaieuaaith aeia?iyeiniith iaoieiai?th ueoiaeaeii? caeice (AIO, AC) oa AeCUC iathoue iinoea aeayei ii?ooaiiy iieacieeia O-eeioeiii? eaiee iioiioaoo - ciaioaiiy eieueeinoi O-caaaeueieo eiioioeeoia i cieaeaiiy ?o ooieoeiiiaeueii? aeoeaiinoi, a iniiaiiio o oai?eo ia aeeoocio oi?io AIO. Cia/iioi ciiie caoieniaaii o aoii?aeueiie eaioei iioiioaoo i /eiieeao ianiaoeeoi/iiai caoenoo, i?e/iio ia oieueee o iaoei?ioia c oe?ai?aeiith iaoieiai?th /e iciaeaie AeCUC, a e o inia aac caoai?thaaiue UC. ?iciiaeie ca oeiaie aiia?naineoeaieo ?aaeoeie iaoei?ioia-o/anieeia EIA icia/aieo a?oi naiae/eoue i?i iayaiinoue niieueieo caeiiiii?iinoae - oea ia?aaaaeaiiy iioiieo ?aaeoeie iaaaeiiai oeio, a naia - iioiieiiieaenieo o anio ianoaaeaieo iaoei?ioia, a oiio /enei e inia aac oe?ai?aeii? iaoieiai?. 7. Iioiia ?aaeoeaiinoue i?e iaoieiai? ueoiaeaeii? caeice o ianaeaiiy noiaeo Oe?a?ie. Aeey ii?iaiyiiy c iaoei?ioaie-/i?iiaeeueoeyie noai iioiii? nenoaie aoei aea/aii o 25 iaoeaioeia noiaeo Oe?a?ie c AeCUC (20 aeiiie i 5 /ieiaieia). Oae naii, ye o o/anieeia EIA c AeCUC, o ianoaaeaieo iaoeaioeia aiaecia/aeinue cieaeaiiy aiaeiinii? eieueeinoi eiioioeeoia ia?eoa?e/ii? e?iai oa aiinoo O-caaaeueieo eiioioeeoia (P<0,02 oa P<0,001 a?aeiia?aeii) i?e aeinoaoiie ?o ooieoeiiiaeueiie aeoeaiinoi. Ii?yae c oeei niinoa?iaaeinue ai?iaiaeia cieaeaiiy eieueeinoi A-eiioioeeoia (P<0,001) oa aeeniioiiaeiaoeiiaiiy, ui noi?iaiaeaeoaaeinue iiaeaeuaiiyi OeIE a 1,75 ?aco, i?eaii/aiiyi oaaioeeoa?ieo aeanoeainoae iaeo?ioieia (ICO cieaeaii o 2 ?ace). O?aaa iiaee?aneeoe, ui o iaoei?ioia c AeCUC, iacaaaeath/e ia iayaiinoue aiaeoeeaiue o O- oa iniaeeai A-eaieao iioiioaoo, a aeiaeiiio aeiaaeeo ia aeyaeaii oee?eoethth/eo aioeoie aei OA oa IA. Aea/aiiy iieacieeia nenoaie iioiioaoo o 18 iaoeaioeia noiaeo Oe?a?ie c aeeoociith oi?iith AIO (11 aeiiie i 7 /ieiaieia) oa 33 oai?eo ic aeeoocii-aoceiaith oi?iith (27 aeiiie oa 6 /ieiaieia) iieacaei iayaiinoue aeaoaeoia ye eieueeinieo oa?aeoa?enoee O-eeioeiii? eaiee iioiioaoo (cieaeaiiy O-caaaeueieo eiioioeeoia, iiaeaeuaiiy O-noi?ani?ia, P<0,05), oae i ?o ooieoeiiiaeueieo aeanoeainoae (i?eaii/aiiy ?AOE c OAA, P<0,05). I?e oeueiio aiaeaoaaeeny ai?iaiaeii cieaeaiiy aaniethoiiai aiinoo A-eiioioeeoia (P<0,01) oa aeeniioiiaeiaoeiiaiiy ci cia/iei iiaeaeuaiiyi ?iaiy OeIE o iaio a?oi iaoei?ioia c AIO (i?e aeeoociie oi?ii o 2,5 ?aco, i?e aeeoocii-aoceiaie oi?ii - o 2,3 ?aco). Cieaeoaaeany oaeiae i oaaioeeoa?ia aeoeaiinoue iaeo?ioieia c i?eaii/aiiyi ICO o 2,9 i 2,6 ?aco i?e aeeoociie i aeeoocii-aoceiaie oi?iao AIO aiaeiiaiaeii. Aiaeic /anoioe aeyaeaiiy aioeoie aei aioeaaiia UC iieacaa iaeaioe/iinoue oeeo ia?aiao?ia i?e iaio oi?iao AIO. Aioeoiea aei OA aeyaeyeeny o 63%, a aei IA - o 80% oai?eo, ye i?aaeei, a na?aaeiio oeo?ao. O 24 iaoeaioeia noiaeo Oe?a?ie c AC (18 aeiiie i 6 /ieiaieia) aoei aiaecia/aii aiaeiai/ii ciiie o eieueeinieo oa?aeoa?enoeeao O-eeioeiii? eaiee iioiioaoo, ye i o iaoeaioeia c AIO (ai?iaiaeia cieaeaiiy eieueeinoi eiioioeeoia, O-caaaeueieo eiioioeeoia, P<0,001, oa iiaeaeuaiiy aiinoo O-noi?ani?ia, P<0,001). Oei /anii ooieoeiiiaeueii oa?aeoa?enoeee (niiioaiii i iioiaai-iiaeoeiaaii) ciii ia caciaee. Aiaeaoaaeinue cia/ia ciaioaiiy (o 3,4 ?aco) aaniethoii? eieueeinoi A-eiioioeeoia i?e aiaenooiinoi aeeniioiiaeiaoeiiaii?. ?iaaiue OeIE aoei iiaeaeuaii o 1,8 ?aco. Aeyaeaii i cieaeaiiy oaaioeeoa?ieo aeanoeainoae iaeo?ioieia: i?e ai?iaiaeiiio (P<0,001) ciaioaiii AAI o oeeo iaoei?ioia ICO aoa iaioei ca eiio?ieue o 2,4 ?aco. Aiaeic /anoioe aeyaeaiiy aioeoie aei aioeaaiia ueoiaeaeii? caeice iieacaa, ui AO aei OA o oai?eo ia AC aeyaeyeeny o 33%, a aei IA o 54%, ui naiae/eoue i?i iayaiinoue iciae aooiaa?ani? o iaaii? /anoeie oai?eo ia AC. C o?aooaaiiyi iiaeeeainoi ?icaeoeo iaiieanoe/ii? o?ainoi?iaoei? ueoiaeaeii? caeice ia oei aiaieuaai? aeia?iyeinii? oe?ai?aeii? iaoieiai? oa ?iei a oeueiio iioiii? nenoaie iaie aoei aeineiaeaeaii noai iioii?aaeoeaiinoi o 14 oai?eo (13 aeiiie i 1 /ieiaie), iaoeaioeia noiaeo Oe?a?ie, c oe?ai?aeiei ?aeii. Aea/aiiy iieacieeia noaio iioiioaoo o iaeieiaaieo oai?eo ia oe?ai?aeiee ?ae naiae/eei i?i iayaiinoue ooeiaeaeaiue ye o O-, oae i o A-eaieao iioiioaoo. Oei ciiie noinoaaeeny ye eieueeinieo ia?aiao?ia (ciaioaiiy aiinoo eiioioeeoia, P<0,001; O-caaaeueieo, P<0,001; O-aeoeaieo, P<0,001; caieueoaiiy O-noi?ani?ia, P<0,001), oae i yeinieo - o 2 ?ace aoei cieaeaii caeaoiinoue O-eiioioeeoia aei aeano?ainoi?iaoei? iiae aieeaii OAA. I?e oeueiio iiaeaen noeioeyoei? aoei cieaeaii o 3 ?ace ii?iaiyii c eiio?ieai. O?aaa iiaee?aneeoe, ui ciiie uiaei O-eeioeiii? eaiee iioiioaoo o oai?eo ia oe?ai?aeiee ?ae aoee ae?aaeaii cia/iioa, iiae i?e aeia?iyeiniie oe?ai?aeiie iaoieiai? oa AeCUC. Iioaineaiinoue ciii o aoii?aeueiie eaioei iioiioaoo i nenoaii ianiaoeeoi/iiai caoenoo o oeeo iaoei?ioia (cieaeaiiy aaniethoii? eieueeinoi A-eiioioeeoia o 2 ?ace; iiaeaeuaiiy OeIE o 2 ?ace, ii?ooaiiy o aie cieaeaiiy AAI oa ICO) aoea oaeith ae, ye i i?e iioie aea/aiie iaie oe?ai?aeiie iaoieiai?. Aiaeic /anoioe aeyaeaiiy aioeoie aei aioeaaiia UC iieacaa, ui iaeaea o o?aoeie oai?eo ia oe?ai?aeiee ?ae aoei aeiaeaeaii AO aei OA i IA o iecueeeo oa na?aaeiio oeo?ao, ui naiae/eoue i?i iayaiinoue aooiiioiieo i?ioeania o oeeo oai?eo i iiaea aooe iaoiiaeaii noeoiiith iieieiai/iith i aooiiioiiith iaoieiai?th. Aeey eiiieaeniiai aiaeico noaio iioiii? nenoaie aoei aaeeoi eiii'thoa?eciaaiee iiaeoiae aei anoaiiaeaiiy iioiieiai/iiai aeiaaiico c aecia/aiiyi oeiia iioiiiaoieiai/ieo ?aaeoeie. Na?aae ianoaaeaieo iaoeaioeia noiaeo Oe?a?ie c AeCUC o 28% aeiaaeeia aeyaeaii iioiieiiieaeniee oei iioiieo ?aaeoeie, a o ia?aaaaeii? a?eueoino? - 72% aiia?naineoeaieo ?aaeoeie acaaaei ia aoei ciaeaeaii. Eiii’thoa?eciaaia aenia?oeca oeiia iioiieo ?aaeoeie o oai?eo c AIO (aeeoocia oa aeeoocii-aoceiaa oi?ia) naiae/eea, ui o oeeo iaoei?ioia ia?aaaaeaa (83 i 70% aiaeiiaiaeii) iioiieiiieaeniee oei ?aaeoeie, o 11 i 15% caoieniaaii oeeoioiene/iee oei. Eeoa o 6% ianoaaeaieo iioiiiaoieiai/ii ?aaeoei? aoee aiaenooii, a o 9% iaoei?ioia c AIO (aeeoocii-aoceiaa oi?ia) niinoa?iaaany ?aaaiiiaee oei. O oai?eo ia aoceiaee cia, oae naii ye i i?e AeCUC i AIO, ia?aaaaeaa iioiieiiieaeniee oei iioiiiaoieiai/ieo ?aaeoeie. *anoioa aecia/aiiy oeeoioiene/iiai oeio (17%) aiaeiiaiaeaea oaeie o iaoei?ioia c aeeoocii-aoceiaith oi?iith AIO. Oaeo ae naio noiaeinoue anoaiiaeaii i aeey ?aaaiiiaiai oeio iioiiiaoieiai/ieo ?aaeoeie. Aiaenooiinoi iioiiiaoieiai/ieo ?aaeoeie o oai?eo ia AC ie ia caoienoaaee. O oai?eo aea ia oe?ai?aeiee ?ae iioiiiaoieiai/ii ?aaeoei? aoee aiaenooii o 7% ianoaaeaieo. O 86% iaoei?ioia, ye i o ?aooe ianoaaeaieo, aeyaeyany iioiieiiieaeniee oei ?aaeoei? i o 7% - ?aaaiiiaee. Oaeei /eiii, ocaaaeueithth/e caeiaooi iaie ?acoeueoaoe uiaei iioiieiai/ii? ?aaeoeaiinoi i?e iaoieiai? ueoiaeaeii? caeice (AC, AIO, ?UC) oa AeCUC o iaoeaioeia noiaeo Oe?a?ie, iiaeia neacaoe, ui anii noaiai i?eoaiaiii ii?ooaiiy caeaaieueoiai a aoii?aeueiie eaioei iioiioaoo. O-eeioeiiee iioiioao ciiith?oueny iaioa, aea iioaineaiinoue eiai ii?ooaiiy ia?inoa? - aiae aeia?iyeinieo, aooiiioiieo caoai?thaaiue ueoiaeaeii? caeice aei oe?ai?aeiiai ?aeo. I?e anio oe?ai?aeieo caoai?thaaiiyo, iaaioue i?e AeCUC, aeyaeyeeny eeoa ?aaeoei? aiia?/ooeeainoi iaaaeiiai oeio, ui iiaeoaa?aeaeo? i?iaiaeio ?ieue aoii?aeueii? eaiee iioiioaoo a iaoiaaiaci oe?ai?aeii? iaoieiai?. I oie oaeo, ui o 28% iaoei?ioia c AeCUC aeyaeaii iioiieiiieaeniee oei iioiiiaoieiai/ieo ?aaeoeie, ? naiae/aiiyi caiouaiiy aaea iioiieiai/iiai iaoaiicio oi?ioaaiiy oe?ai?aeii? iaoieiai? o iaaii? eieueeinoi oeeo inia, ui, aei ?a/i, caiaa?oueny c iayaiinoth oe?ai?aeieo ai?iiiaeueieo c?ooaiue o /anoeie iaoei?ioia c AeCUC. Aeyaeaii oaeiae i iaaii caaaeueii iioiieiai/ii caeiiiii?iinoi i?e AIO, AC oa ?UC, ui iiaea aeacoaaoe aai ia iioiieiai/io niieueiinoue oeeo caoai?thaaiue, aai/ oa iiaeeeainoue aeieeiaiiy iaeii?? oe?ai?aeii? iaoieiai? ia oei iioi?. 8. I?eioeeie aeeniaina?iiai iaaeyaeo ca o/anieeaie eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN c iaoieiai?th ueoiaeaeii? caeice c i?aeoe/ieie ?aeiiaiaeaoeiyie. Anoaiiaeaii iaie oaeoe uiaei c?inoaiiy /anoioe i oa?aeoa?o oe?ai?aeii? iaoieiai? a o/anieeia EIA ia *AAN, ui aeieea?, iniaeeainoi ai?iiiaeueii-iioiieiai/ieo iieacieeia, iiaeeeainoue inioaaiiy noeoiii? oe?ai?aeii? iaoieiai? oa aeieeiaiiy caoai?thaaiue ueoiaeaeii? caeice iaaioue ia oei ?? aeeoociiai caieueoaiiy Ia-II no. - ona oea coiiaeth? iaiaoiaeiinoue iieiioaiiy aeeniaina?iiai iaaeyaeo ca o/anieeaie eieaiaeaoei? ?aaeiaoeieii? aaa?i? c iaoith nai?/aniiai i i?aaeeueiiai anoaiiaeaiiy oa?aeoa?o iaoieiai? ueoiaeaeii? caeice, ianaiia?aae aeey caiiaiaaiiy ?icaeoeo oe?ai?aeiiai ?aeo. Cai?iiiiiaaia iaie nenoaia aeeniaina?iiai iaaeyaeo neeaaea?oueny c icia/aieo ieae/a caoiaeia i ia?aaeaa/a? aeei?enoaiiy i?iiaiaaeo in vivo oa in vitro iaoiaeia aeiaaiinoeee (OCAe, ?IA) ye iaeaieueo aaeaeaaoieo oa iicaaaeaieo iaaaoeaiiai aieeao ia i?aaiici. Aeeniaina?iiio iaaeyaeo iiaeeyaathoue ani o/anieee EIA ia *AAN. Aiie, ye i iaoei?ioe c aeeoociei ca?eueoaiiyi ueoiaeaeii? caeice aoaeue-yeiai nooiaiy, iathoue aooe iaeyiooi ?aaeiieiaii aai aiaeie?eiieiaii 1 ?ac ia ?ie. Iaoei?ioe c aecia/aiei aeiaaiicii AIO (aeeoocia oi?ia) iio?aaothoue iaaeyaeo 1 ?ac o 6-8 iin; AIO (aeeoocii-aoceiaa oi?ia) - 1 ?ac o 4-6 iin; aoceiaee oa ciioaiee cia - 1 ?ac o 4-6 iin. Ca ne?eiiiaiaee niinia ianoaaeaiiy, yeee neiae canoiniaoaaoe i?e eiaeiiio aeeniaina?iiio iaeyaei, o?aaa aaaaeaoe aoineiiith ueoiaeaeii? caeice. Aaeueie iaiaoiaeiei ? aecia/aiiy o o/anieeia EIA ia *AAN c oe?ai?aeiith iaoieiai?th c aeei?enoaiiyi ?IA ?iaiia O4 i OOA, ye iaeaieueo iioi?iaoeaieo iieacieeia noaio ueoiaeaeii? caeice. Ae?oaith aaaeeeaith eaieith ianoaaeaiiy ? aea/aiiy noaio iioiii? nenoaie c aecia/aiiyi oeiia iioiieiai/ieo ?aaeoeie ca Gell i Coombs aeey aeai?o oeyoia iiaeeeai? iioiiei?aeoei? o iaoei?ioia ic eeiii/ii anoaiiaeaiith oe?ai?aeiith iaoieiai?th. I?e iayaiinoi aoceiaeo ooai?aiue aoaeue-yeiai aeiaiao?a iaia'yceiaei ? i?iaaaeaiiy aeiaaiinoe/ii? oiieiaieeiai? ioieoeieii? aiiini? ca ?ic?iaeaiith iaie iaoiaeeeith iiae eiio?ieai OCAe c oeeoieiai/iei aeineiaeaeaiiyi aeeo/aiiai iaoa?iaeo (iioi?iaoeaiinoue oaeiai aeineiaeaeaiiy noaiiaeoue 96%, ii?iaiyii c aiiini?th aac ianaaeee - 76%). Aeeniaina?ecaoeiy eieaiaeaoi?ia ianeiaeeia aaa?i? ia *AAN ia? aooe aaaaoi?iaiaaith i i?iaiaeeoenue o aeeniaina?ao ?aaeiaoeieiiai caoenoo ianaeaiiy aai a aiaeie?eiieiai/ieo aeeniaina?ao (?aeiiieo, iinueeeo oa iaeanieo); o ?aci aeyaeaiiy aoceiaeo ooai?aiue o ueoiaeaeiie caeici i?e iaeyaei oa iiaeoaa?aeaeaiii eaaeioieiaaiei oaoiaoeai OC-aeiaaiinoii iiaeaeueoa ianoaaeaiiy i eieoaaiiy neiae i?iaiaeeoe o niaoeiaeiciaaieo iaaee/ieo caeeaaeao. sseui oi?o?ai/ia ao?o/aiiy c i?eaiaeo aoceiaeo ooai?aiue ueoiaeaeii? aoei caeieniaii a iioeo iaaee/ieo caeeaaeao, iaiaoiaeiith ? eiinoeueoaoeiy oai?iai oa ainoieiai/ieo i?aia?aoia o aeaioeaeiaaee oa?iii c iiiaioo i?iaaaeaiiy oi?o?ai/iiai eieoaaiiy o Oa?eianueeiio IAeI iaaee/ii? ?aaeiieiai? aai Ee?anueeiio IAeI iieieiai? oa ?aaeiieiai?. Ia iiaenoaai ?acoeueoaoia, caeiaooeo iaie i?e aeineiaeaeaiii noaio aiiioica?ii-oe?ai?aeieo aca?iiaiaeiinei oa iioiieiai/ii? ?aaeoeaiinoi, c o?aooaaiiyi oa?aeoa?o oe?ai?aeii? iaoieiai? o eieaiaeaoi?ia aaa?i? ia *AAN, c iaoith ei?aeoei? ai?iiiaeueiiai aaeaino, iiaeia ?aeiiaiaeoaaoe: 1. I?e aeyaeaiii a o/anieeia EIA ia *AAN iciae ia?aeiiiai aiiioe?aico, ui noi?iaiaeaeo?oueny cieaeaiiyi ?iaiia O3 i/aai O4 c ii?iaeueiei (nii/aoeo) aai iiaeaeuaiei ?iaiai OOA - i?ecia/aiiy oe?ai?aeieo ai?iiiia (L-oe?ienei oa ii.) o oaeeo aeicao, uia aeinyaoe ii?iaeicaoei? ?iaiy OOA, ui iniaeeai aaaeeeai a oeeo oiiaao aeey caiiaiaaiiy eiiiainaoi?iie i?ieioa?aoei? oe?ai?aeiiai aiioaeith i iiaeeeaiai ?icaeoeo oe?ai?aeiiai ?aeo. 2. I?e iayaiinoi o iaoei?ioia - o/anieeia EIA noaeeiii/ieo iciae cieaeaiiy oe?aio?iiii? ooieoei? aiiioico (cieaeaiiy ye ?iaiia oe?ai?aeieo ai?iiiia, oae i OOA, aai eiai "ioeueiaa" cia/aiiy), iiaeia i?ecia/aoe aeaui ieae/i aeice oe?ai?aeieo ai?iiiia, yei aeeiiothoue eeoa eiiiainaoeieio ?ieue. 3. Ca iayaiinoi a ueoiaeaeiie caeici o/anieeia EIA aoceiaeo ooai?aiue aoaeue-yeiai aeiaiao?a, ui iathoue oaiaeaioeith aei caieueoaiiy aai eeoathoueny aac aeeiaiiee iiae aieeaii aaeaeaaoiiai eieoaaiiy i?ioyaii 6 iinyoeia, iiaeaeuaiiio ?iaii iooeeiieo ia?ea?ia (OA, ?AA) aeioeieueiei ? oi?o?ai/ia eieoaaiiy, yeiio ia?aaeo? eiiieaenia ianoaaeaiiy c iaoith aa?eoieaoei? aeiaaiico ia eiiia?aoe?eiiio aoaii. 4. I?e iayaiinoi o iaoei?ioia aeia?iyeinii? aoceiai? iaoieiai? ueoiaeaeii? caeice, aa?eoieiaaii? oeeoieiai/ii, ii?iaeueieo ?iaiia iooeeiieo ia?ea?ia, oaiaeaioei? aei ciaioaiiy ?icii?ia aoceiaeo ooai?aiue iiae aieeaii eieoaaiiy aai noaeee ?o noai - iiaeeeaei ? i?iaaaeaiiy eiina?aaoeaiiai eieoaaiiy iiae eiio?ieai aoi-?aaeiiiioiieiai/iiai ianoaaeaiiy (2 ?ace ia ?ie). Oaeei /eiii, iaie iaoiaaiaoe/ii iaa?oioiaaii canoinoaaiiy iaoiaeia i?iiaiaai? aeiaaiinoeee iaoieiai? ueoiaeaeii? caeice a o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN. Io?eiaii a ?acoeueoaoi oeueiai iaoeiai aeaii aeicaieeee noai?eoe aaaaoi?iaiaao nenoaio aeeniaina?ieo caoiaeia ic aeiaaiinoe/ii-eieoaaeueieie ?aeiiaiaeaoeiyie, ui ni?yiiaaia ia i?ioieaeoeeo i nai?/ania aeyaeaiiy caoai?thaaiue ueoiaeaeii? caeice a no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao Oe?a?ie c iaoith iiiiiicaoei? aiaeaeaeaieo noioanoe/ieo oe?ai?aeieo aoaeoia. CAEETH*AIIss sse iieacaei canoinoaaiiy i?iiaiaaeo in vivo oa in vitro iaoiaeia aeineiaeaeaiiy o aea/aiii iniaeeainoae aeieeiaiiy oa oa?aeoa?o ia?aaiao oe?ai?aeii? iaoieiai? a o/anieeia EIA ia *AAN, i?iaiaeiith iaoieiai?th ueoiaeaeii? caeice iiney ?? aeeoociiai caieueoaiiy Ia-II no. ? aooiiioiiee oe?ai?aeeo, i?e/iio iioe?aiinoue eiai na?aae oei?? eaoaai?i? iaoei?ioia c /anii c?inoa?. Caieueoo?oueny oaeiae i ieoiia aaaa aoceiaiai ciaa. Oa?iiie aeieeiaiiy oe?ai?aeii? (aeeoocii? oa aiaieuaai?) iaoieiai? a o/anieeia EIA, ca iaoeie ?ic?aooieaie, caeaaeaee aiae iiiaioo aaa?i?, a oa?aeoa? iiaeaeueoiai ?icaeoeo oe?ai?aeieo caoai?thaaiue coiiaethaaany naia ia?aaoaaiiyi o ciii aei? iiiicoaaeueiiai aei?iiiiaiiy. ?aaeiiiioiieiai/iee aiaeic ooieoeiiiaeueii? aeoeaiinoi ueoiaeaeii? caeice oa aiiioica?ii-oe?ai?aeieo aca?iei i?e oe?ai?aeiie iaoieiai? a o/anieeia EIA ia *AAN (AIO, AC) oa a inia c AeCUC naiae/eoue i?i iayaiinoue ciii o iaaii? /anoeie oai?eo, ui i?iyaeythoueny ia?aaaaeii cieaeaiiyi ?iaiy O4 i?e aiaeiiniie noaaieueiinoi O3, cieaeaiiyi aiinoo OOA oa iiaeaeuaiiyi ?iaiia iooeeiieo ia?ea?ia. Aeeiaii/ia niinoa?aaeaiiy ca oeeie iieacieeaie, ii/eiath/e c oa?iiio 6 iin. iiney iiaa?iaiiy c ciie ?aaeiaoeieii? aaa?i? i aeaei i?ioyaii 6-8 ?ieia, naiae/eei i?i iayaiinoue niieueieo caeiiiii?iinoae i?e eiaeiiio aeaei iaoieiai? ueoiaeaeii? caeice i ?? aeeoociiio caieueoaiii Ia-II no.: iiaeeii-iie-cieaeaiiy aei ii?iaeueieo, a aeaei i aei noaii?iaeueieo iieacieeia. I?e oeueiio aiino O3 aiaecia/aany aieueoith noaaieueiinoth, a cieaeaiiy O4 aoei aieueo cia/ouei. Oey caeiiiii?iinoue, iniaeeai uiaei cieaeaiiy OOA, caa?iaaeanue i aeey o/anieeia EIA c iioaeoiith ueoiaeaeiith caeicith. C oeueiai aeieeaa?, ii-ia?oa, ui AeCUC a o/anieeia EIA ia *AAN ia iiaeia aiaeianoe aei ii?iaeueiiai noaio, o iaaii? /anoeie iaoei?ioia - oea aeenai?iiiaeueiee oii, ia yeiio iiaea aeieeaoe aoaeue-yea oe?ai?aeia iaoieiaiy. Ii-ae?oaa, o /anoeie iaoei?ioia-o/anieeia EIA c AeCUC, AIO, AC, ii?yae c i?iyaaie noaeeiii/iiai ia?aeiiiai aiiioe?aico, aeyaeaii i iciaee cieaeaiiy oe?aio?iiii? ooieoei? aiiioica, yea c /anii i?ia?ano?. Aeyaeaii i?yio caeaaeiinoue iiae nooiaiai i?eaii/aiiy oe?aio?iiii? ooieoei? aiiioica i aeiciaei iaaaioaaeaiiyi, ui aeicaiey? i?eionoeoe iayaiinoue ?aaeiaoeieii iaoiiaeaieo iciae iaoieiai? ueoiaeaeii? caeice i aiiioica?ii? noa?e aianeiaeie ye aei? icioiiia eiaeo ia ueoiaeaeio caeico, oae i ciaiioiueiai ii?iiiiaiiy iiceo, iai?yiiai ?aaeiaoeieiiai aieeao oa ?? no?ani?ieo aoaeoia c aeeneii?aeeiaoei?th aiiioaeaion-aiiioic-iaaeie?eiai? nenoaie, ui iiaea iaoiiaethaaoe noi?anith o?iiieo ai?iiiia aiiioica (O.A.Aeoaeiia, 1981; A.I.Eiaaeaiei ic niiaaao., 1994; A.E.*aaai, 1995; I.A.Iio?y?aa, 1996). Ia aiaeiiio aiae neacaiiai aeua, iaoieiaiy ueoiaeaeii? caeice o ianaeaiiy noiaeo Oe?a?ie o no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao oa?aeoa?eco?oueny caaaeueiiaiaeiieie ciiiaie a nae?aoei? oe?ai?aeieo ai?iiiia i OOA i ia noi?iaiaeaeo?oueny cia/ieie aeeiaii/ieie eieeaaiiyie ai?iiiaeueieo iieacieeia i?ioyaii iineyaaa?ieieo ?ieia. Iaie anoaiiaeaii iaaii ?icaiaeiinoi a iaoiaaiaci oe?ai?aeii?, cie?aia aooiiioiii? iaoieiai? a o/anieeia EIA i iaoeaioeia noiaeo Oe?a?ie. sseui a inoaiiio iaie aeyaeaii ciiie ye O-, oae i A-eeioeiii? eaiie iioiioaoo, aeenaaeain o ooieoeiiioaaiii yeeo coiiaeth? i iiaeo?eio? iioiiiaoieiai/iee i?ioean, oi a o/anieeia EIA i?e iayaiinoi iaaieo c?ooaiue o O-eeioeiiie eaioei i?iaiaeiei ? ooeiaeaeaiiy aoii?aeueii? eaiee iioiioaoo. Oea, i/aaeaeii, coiiaeaii ye aieeaii ?aaeiaoeieiiai /eiieea ia oe?ai?aeii oieieoee i iiina?aaeeiaaii - ia nenoaio iioiioaoo, oae i aaciina?aaeiuei ia A-eiioioeeoe ye iaeaieueo ?aaeii/ooeeai (?.A.AEa?aii, A.A.*ooeiaii, 1989; N.A.Eiiina?aiei, E.I.Cae , 1994.). Oeyoii canoinoaaiiy i?iiaiaaeo aoi-?aaeiiiioiieiai/ieo iaoiaeia aeineiaeaeaiue anoaiiaeaii aeayei iiai iniaeeainoi iaoiaaiaco oa ia?aaiao caoai?thaaiue ueoiaeaeii? caeice na?aae o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN, c o?aooaaiiyi oeueiai cai?iiiiiaaii nenoaio aeeniaina?iiai iaaeyaeo ca iaoei?ioaie oei?? eaoaai?i?. Oey nenoaia ? aaaaoi?iaiaaith i aaco?oueny ia ?aaeaiaioiaaieo ca /anii aeeniaina?ieo iaeyaeao oa canoinoaaiii aeiaaiinoe/ieo caoiaeia aeey nai?/aniiai aeyaeaiiy oe?ai?aeieo caoai?thaaiue, a oiio /enei i iieieiai/ieo: OC-iiiioi?eia, aecia/aiiy O4 i OOA, iioiiiai noaoono, IAA aoceiaeo ooai?aiue ueoiaeaeii? caeice aoaeue-yeiai aeiaiao?a iiae eiio?ieai OCAe ca ?ic?iaeaiith iaie iaoiaeeeith ic oeeoieiai/iei aeineiaeaeaiiyi aeeo/aiiai iaoa?iaeo (iioi?iaoeaiinoue aeineiaeaeaiiy - 96%) aeey aa?eoieaoei? oa?aeoa?o oe?ai?aeii? iaoieiai? o oei?? eaoaai?i? iaoei?ioia. Oaeei /eiii, ca aeiiiiiaith i?iiaiaaeo in vivo oa in vitro iaoiaeia aeiaaiinoeee anoaiiaeaii iniaeeainoi iaoiaaiaco caoai?thaaiue ueoiaeaeii? caeice, ?ic?iaeaia nenoaia aeeniaina?iiai iaaeyaeo, ni?yiiaaia ia iieiioaiiy yeinoi aeiaaiinoeee oeeo caoai?thaaiue, o oiio /enei i iieieiai/ieo, ui aeicaiey? aecia/eoe oa?aeoa? eieoaaeueieo caoiaeia (eiina?aaoeaii, oi?o?ai/ii) i?e oe?ai?aeiie iaoieiai? o inia, yei a?aee o/anoue a eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN oa aeaeieeoe a?oie “?eceeo” uiaei ?icaeoeo oe?ai?aeiiai ?aeo c iaoith iiiiiicaoei? aiaeaeieaieo noioanoe/ieo oe?ai?aeieo aoaeoia. AENIIAEE 1. Aeei?enoaiiy i?iiaiaaeo iaoiaeia in vivo oa in vitro aeiaaiinoeee a eiiieaeniiio eeiiiei-eaai?aoi?iiio iii?oi?eiao o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN aeicaieeei c'ynoaaoe iaoiaaiaoe/ii iaoaiicie aeieeiaiiy ?icaeoeo oa ia?aaiao oe?ai?aeii? iaoieiai?, ui aoei iieeaaeaii a iniiao ?ic?iaeaii? nenoaie aeeniaina?ecaoei? oei?? eaoaai?i? oai?eo, ni?yiiaaii? ia i?ioieaeoeeo, nai?/anio aeiaaiinoeeo oa aeai? iaoiaeo oa?aii? caoai?thaaiue ueoiaeaeii? caeice. 2. *a?ac 10 ?ieia iiney aaa?i? ia *AAN iniiaiith oe?ai?aeiith iaoieiai?th a o/anieeia eieaiaeaoei? ?? ianeiaeeia ia noiaei Oe?a?ie ? aooiiioiiee oe?ai?aeeo oa aoceiaee cia (20 oa 22% na?aae iioi? iaoieiai? ueoiaeaeii? caeice). 3. *an aeyaeaiiy AeCUC Ia-II no. oa aoceiai? oe?ai?aeii? iaoieiai? a o/anieeia EIA ia *AAN aecia/a?oueny ia noieueee oa?iiiii ia?aaoaaiiy ?o o ciii ?aaeiaoeieii? aaa?i?, neieueee /anii naii? aaa?i?, oiaoi iiaeiyie, yei iaee iinoea a Oa?eiai i Oa?eianueeie iaeanoi o ia?oi iineyaaa?ieii aeii (iiaeaeuaiiy ia'?iii? eiioeaio?aoei? 131I a iiaio?i o 8,5 ?aco, ii?iaiyii c i?eionoeiei). 4. Ia?aaia oe?ai?aeii? iaoieiai? (AIO, AC) oa AeCUC Ia-II no. o iaaii? /anoeie o/anieeia EIA ia *AAN ca aeaieie ?IA oa?aeoa?eco?oueny i?iyaaie ye noaeeiii/iiai aiiioe?aico (aianeiaeie o?aaeaiiy ueoiaeaeii? caeice icioiiaie eiaeo), oae i noaeeiii/ieie iciaeaie i?eaii/aiiy oe?aio?iiii? ooieoei? aiiioico aianeiaeie aieeao ia aiiioaeaii-aiiioica?ii no?oeoo?e i?yii? i iai?yii? aei? iiiicoaaeueii? ?aaeiaoei? (cieaeaiiy aiinoo OOA o 39-71% iaoei?ioia c AC oa AIO). 5. Anoaiiaeaii iayaiinoue aeicicaeaaeiiai aoaeoo iiae io?eiaiith aeicith ciaiioiueiai aei?iiiiaiiy i nooiaiai cieaeaiiy OOA a o/anieeia EIA ia *AAN. O iaoei?ioia c iaoieiai?th ueoiaeaeii? caeice (AIO, AC) i aac ?? o?aaeaiue c aeicith ciaiioiueiai ii?iiiiaiiy aeuith 250 iCa niinoa?iaaeinue ai?iaiaeia i?eaii/aiiy oe?aio?iiii? ooieoei? aiiioica. 6. Aeeiaii/ia niinoa?aaeaiiy ca ?iaiai OOA a o/anieeia EIA ia *AAN ye c oe?ai?aeiith iaoieiai?th, oae i aac ia? (i?ioyaii 8 ?ieia iiney caeii/aiiy ?iaio a ciii aaa?i?) naiae/eoue i?i eiai iinooiiaa cieaeaiiy, iaeaieueo ae?aaeaia o iaoei?ioia c AIO. 7. A eeiii/iie eeaneoieaoei? AIO neiae aeaeieyoe aeeoocio oa aeeoocii-aoceiao oi?ie caoai?thaaiiy ca oiia oeeoieiai/iiai iiaeoaa?aeaeaiiy aooiiioiiiai i?ioeano o ueoiaeaeiie caeici i aoceiaiio ooai?aiii. 8. Iaoiaaiaoe/ii iaoaiicie ?icaeoeo ?aaeiaoeieii coiiaeaiiai aooiiioiiiai oe?ai?aeeoo a o/anieeia EIA ia *AAN iiina?aaeeiaaii ia?aaaaeii /a?ac aoii?aeueio eaieo iioiioaoo i nenoaio ianiaoeeoi/iiai caoenoo i?aaiicio c i?aaaethaaiiyi aiia?naineoeaieo ?aaeoeie iaaaeiiai oeio. 9. Iaoei?ioe - o/anieee EIA c oe?ai?aeiith iaoieiai?th oa AeCUC Ia-II no. i iiaeaeuaieie ?iaiyie OA oa ?AA (60-76 % ianoaaeaieo) neeaaeathoue a?oio ?eceeo ii aeieeiaiith iooeei ueoiaeaeii? caeice i iio?aaothoue aeeniaina?iiai iaaeyaeo. 10. AeCUC Ia-II no. o aei?ineeo a no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao Oe?a?ie ? ia?aaeiaoieiai/iei noaiii, ia oei yeiai iiaea aeieeaoe aoaeue-yea oe?ai?aeia iaoieiaiy. Iaoei?ioe c AeCUC Ia-II no. iio?aaothoue aeeiaii/iiai niinoa?aaeaiiy, a i?e iaiaoiaeiinoi - iioiiai?iiiaeueii? ei?aeoei?. NIENIE ?IAIO, IIOAEIEIAAIEO CA OAIITH AeENA?OAOeI? 1. ?icaeeeuenueeee N.E., Aoaianueaaa I.E., Ia/eiiaa I.A. Iniaaiiinoe eeeie/aneiai oa/aiey e oa?aiee ?aea ueoiaeaeiie aeaeacu o aeaoae// Oa?. a?oea. - 1992. - ?10. - N.170-175. 2. Aoaianue?aa I.I., Oea/aiei A.I., Anoai'?aa I.I., Eiceinueea I.I. oa ii. E?eoa?i? oi?ioaaiiy "a?oie ?eceeo" aeieeiaiiy caoai?thaaiue ueoiaeaeii? caeice na?aae eieaiaeaoi?ia aaa?i? ia *AAN// O?AE. -1994. - ?1. - N.14-16. 3. Oea/aiei A.I., ?icaeieuenueeee N.I., Iineaeaiei I.A., Eiiioaiei TH.O., Anoai'?aa I.I., Aoaianue?aa I.I. Eeiii/iee ia?aaia, i?iiaiaaa aeiaaiinoeea oa oa?aiiy ?aeo ueoiaeaeii? caeice o aeioae oa iiaeeioeia// O?AE. - 1995. - ?4. - N.308-311. 4. Oea/aiei A.I., Aoaianue?aa I.I., E?oaeieia I.E., sseeiiaa O.I. Aeeiaiiea i no?oeoo?a oe?ai?aeii? iaoieiai? na?aae ianaeaiiy Oe?a?ie ca 1984-1994 ??.// O?AE. - 1995. - ?1. - N.17-22. 5. Aoaianue?aa I.I. Oa?aeoa?enoeea caoai?thaaiue ueoiaeaeii? caeice a o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN// O?AE. - 1996. - ?4. - N.349-352. 6. Aoaianue?aa I.I. Iioiia ?aaeoeaiinoue i oe?ai?aeia iaoieiaiy o o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN. Iiaiaeiieaiiy I. Aiia?ieaciy ueoiaeaeii? caeice// O?AE. - 1997. - ?1. - N.19-21. 7. Aoaianue?aa I.?. iioiia ?aaeoeaiinoue i oe?ai?aeia iaoieiaiy o o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN. Iiaiaeiieaiiy II. Aeia?iyeinia oa ceiyeinia oe?ai?aeia iaoieiaiy// O?AE. - 1997. -?2. - N.162-166. 8. Aoaianue?aa I.I. Aeeiaii/ii ii?ooaiiy nae?aoei? oe?ai?aeieo ai?iiiia i OOA o eieaiaeaoi?ia ianeiaeeia aaa?i? ia *AAN c aeeoociith oi?iith AIO/ I?iiaiaaa aeiaaiinoeea, i?iiaiaaa oa?aiiy/Ca. iaoeiaeo ?iaio Anioeiaoei? ?aaeiieiaia Oe?a?ie (Aeione 3). E., 1998. N.65-7. 9. Aoaianue?aa I.I. Iniaeeainoi oe?ai?aeiiai ai?iiiaeueiiai aiiainoaco i?e aiia?ieaci? ueoiaeaeii? caeice o eieaiaeaoi?ia ianeiaeeia aaa?i? ia *AAN// O?AE. - 1998. - ?2. - N.182-185. 10. Aoaianue?aa I.I., THaeiia I.A. ?ieue oa iinoea i?eoeieueii? anii?aoeieii? aiiini? iiae eiio?ieai OCAe o aeiaaiinoeoei oe?ai?aeii? iaoieiai? a no/anieo oiiaao/ I?iiaiaaa aeiaaiinoeea, i?iiaiaaa oa?aiiy/ Ca. iaoeiaeo ?iaio Anioeiaoei? ?aaeiieiaia Oe?a?ie (Aeione 3). E., 1998. -N.70-75. 11. Aoaianue?aa I.I. Aiiioica?ii-oe?ai?aeia nenoaia o inia, ui a?aee o/anoue a eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN. Aieea aeic ciaiioiueiai ii?iiiiaiiy// O?AE. - 1998. - ?2. - N.186-188. 12. I.I.Aoaianue?aa, A.I.Oea/aiei, I.I.Eoeaoiaa oa ii. No?oeoo?ii-ooieoeiiiaeueii iniaeeainoi ueoiaeaeii? caeice o oai?eo c ?? aoceiaeie ooai?aiiyie. I. Oeueo?ano?oeoo?a aaeaiiiaoicii ciiiaii? ueoiaeaeii? caeice o oai?eo ia aoceiaa aiei// O?AE. -1998.-?2. - N.176-181. 13. Aoaianue?aa I.I. Iniaeeainoi oe?ai?aeiiai ai?iiiaeueiiai aiiainoaco i?e caoai?thaaiiyo ueoiaeaeii? caeice o no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao Oe?a?ie// O?AE. - 1998. -?6. - N.354-357. 14. Aoaianue?aa I.I. Oe?ai?aeia ea?oeeiiia o eieaiaeaoi?ia ianeiaeeia aaa?i? ia *AAN// Ainiee i?iaeai aiieiai? i iaaeeoeeie. - 1999. - ?5. - N.87-90. 15. ?ioaiiy i?i aeaea/o iaoaioo ia ei?enio iiaeaeue ? 98084257/E aiae 16.02.1999. "I?eno?ie aeey anii?aoeieii? oiieiaieeiai? ioieoeieii? aiiini?". 16. Anoai'?aa I.I., ?icaeieuenueeee N.I., Oea/aiei A.I., Aoaianue?aa I.I., Aaneeue?a E.ss. I?iaiinoe/ia ioeiiea aoaeoeaiinoi eieoaaiiy oai?eo ia ?ae ueoiaeaeii? caeice // O?AE. - 1999. - ?1. - N.15. 17. Aoaianueaaa I.E. Aooieiioiiue oe?aieaeeo. Aii?inu eeeie/aneie eeanneoeeaoeee// AEo?iae i?aeoe/iiai eiea?y. - 1999. - ?1. - N.34-35. 18. Aoaianue?aa I.I. ?aaeoeiy aiiieaeaiona i aiiioica ia iiiicoaaeueia aei?iiiiaiiy// O?AE. - 1999. - ?2. - N.185-187. 19. Oea/aiei A.I., Aoaianue?aa I.I., Eoeaoiaa I.I., Iaiiothe Y.I., Oaaoeia A.A. Aeineiaeaeaiiy oeueo?ano?oeoo?e eeioei aaeaiiea?oeeiii ueoiaeaeii? caeice o oai?eo c oe?i?aeiei ?aeii. Iiaiaeiieaiiy 2// O?AE. - 1999. - ?3. - N.273-279. AIIOAOe?ss Aoaianue?ai? I.?.Iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy eiiieaeno i?iiaiaaeo iaoiaeia aeineiaeaeaiiy a aeeniaina?iiio iaaeyaei o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN ic oe?aiiaeiith iaoieiai?th Aeena?oaoeiy ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoeiaeueiinoth: 14.01.23 - i?iiaiaaa aeiaaiinoeea i i?iiaiaaa oa?aiiy. - Oe?a?inueeee iaoeiai-aeineiaeiee iinoeooo iieieiai? i ?aaeiieiai?, Ee?a, 1999. Aeena?oaoeith i?enay/aii aeooaeueiie i?iaeaii aea/aiiy iaoiaaiaoe/ieo iaoaiiciia ?icaeoeo oe?ai?aeii? iaoieiai? na?aae o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN ca aeiiiiiaith i?iiaiaaeo iaoiaeia aeiaaiinoeee (OCAe, ?IA) noai?aiiy ia oeie iniiai nenoaie aeeniaina?iiai iaaeyaeo ca oeeie iaoei?ioaie c iaoith iiiiiicaoei? aiaeaeaeaieo noioanoe/ieo oe?ai?aeieo aoaeoia. A ?iaioi ciaeoea nai? aiaeia?aaeaiiy ?ic?iaea i?ii?eoaoiiai iai?yieo a ?aaeiaoeieiie iaaeeoeeii - iiaeoeoeiy caoai?thaaiue ueoiaeaeii? caeice 131I c o?aooaaiiyi aiaeaeaeaieo ianeiaeeia eiai aieeao ca ?acoeueoaoaie iiiioi?eiao inia, ui a?aee o/anoue a eieaiaeaoei? ianeiaeeia aaa?i? (EIA) ia *AAN; aecia/aiiy ?iei oa iinoey i?iiaiaaeo (OCAe, ?IA) iaoiaeia aeineiaeaeaiiy o aea/aiii iaoiaaiaco oe?ai?aeii? iaoieiai? o o/anieeia EIA oa nenoaii aeeniaina?iiai iaaeyaeo ca oeeie iaoei?ioaie aeey nai?/aniiai aeyaeaiiy caoai?thaaiue ueoiaeaeii? caeice; aea/aiiy aca?iiaiaeiinei aiaeie?eiii? oa iioiii? nenoai a aaiaci oe?ai?aeii? iaoieiai? a no/anieo ?aaeiaoeieii-aeieiai/ieo oiiaao noiaeo Oe?a?ie. Anoaiiaeaii, ui iaoaiicie ?icaeoeo oe?ai?aeii? iaoieiai? o o/anieeia EIA i iaoeaioeia noiaeii? Oe?a?ie ?icii, a nooiiiue ie?aieo ai?iiiaeueieo ciii o "eieaiaeaoi?ia" ?aaeiaoeieii? aaa?i? caeaaeeoue aiae aaee/eie aeice ciaiioiueiai ii?iiiiaiiy. Caeiaooi ca aeiiiiiaith aoi-?aaeiiiioiieo iaoiaeia aeineiaeaeaiiy aeaii uiaei iaoiaaiaoe/ieo iaoaiiciia ?icaeoeo caoai?thaaiue ueoiaeaeii? caeice a o/anieeia EIA iieeaaeaii a iniiao ?ic?iaeaii? nenoaie aeeniaina?iiai iaaeyaeo ca iniaaie c oe?ai?aeiith iaoieiai?th, yea iinoeoue a niai eieoaaeueii-aeiaaiinoe/ii caoiaee i ?aeiiaiaeaoei?, ni?yiiaaii ia nai?/ania aeyaeaiiy oe?ai?aeii? iaoieiai?, cie?aia ?aeo ueoiaeaeii? caeice aeey iiiiiicaoei? noioanoe/ieo oe?ai?aeieo aoaeoia. Anoaiiaeaii e?eoa?i? aeaeieaiiy a?oie "?eceeo" uiaei ?icaeoeo caoai?thaaiue ueoiaeaeii? caeice na?aae o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN. Iniiaii ?acoeueoaoe ?iaioe ciaeoee canoinoaaiiy a i?aeoe/iie iaaeeoeeii i?e aeeniaina?iiio iaaeyaei i ianoaaeaiii o/anieeia eieaiaeaoei? ianeiaeeia aaa?i? ia *AAN c iaoieiai?th ueoiaeaeii? caeice. #6.1. Eeth/iai neiaa oe?a?inueeith iiaith: Eeth/iai neiaa: eieaiaeaoi?e ianeiaeeia aaa?i? ia *AAN, i?iiaiaai iaoiaee aeiaaiinoeee in vitro oa in vivo, oe?ai?aeii caoai?thaaiiy, aiiioica?ii-oe?ai?aeia nenoaia, iioiiee noaoon, nenoaia aeeniaina?iiai iaaeyaeo. -- AIIIOAOeEss Aoaianueaaie I.E.Iaoiaaiaoe/aneia iainiiaaiea eniieueciaaiey eiiieaena eo/aauo iaoiaeia enneaaeiaaiey a aeeniaina?iii iaaethaeaiee o/anoieeia eeeaeaeaoeee iineaaenoaee aaa?ee ia *AYN n oe?aieaeiie iaoieiaeae Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe - 14.01.23 - eo/aaay aeeaaiinoeea e eo/aaay oa?aiey. Oe?aeineee iao/ii-enneaaeiaaoaeueneee einoeooo iieieiaee e ?aaeeieiaee, Eeaa, 1999. Aeenna?oaoeey iinayuaia aeooaeueiie i?iaeaia - eco/aieth iaoiaaiaoe/aneeo iaoaieciia ?acaeoey oe?aieaeiie iaoieiaee o o/anoieeia eeeaeaeaoeee iineaaenoaee aaa?ee (EIA) ia *AYN n iiiiuueth eo/aauo iaoiaeia aeeaaiinoeee (OCE, ?EA) e nicaeaieth ia yoie iniiaa nenoaiu eo aeeniaina?iiai iaaethaeaiey n oeaeueth ieieiecaoeee ioaeaeaiiuo noioanoe/aneeo oe?aieaeiuo yooaeoia. A ?aaioa ?acaeaaaony i?ei?eoaoiia iai?aaeaiea a ?aaeeaoeeiiiie iaaeeoeeia - eiaeoeoeey caaieaaaiee ueoiaeaeiie aeaeacu 131I n o/aoii ioaeaeaiiuo iineaaenoaee aai aeeyiey ii ?acoeueoaoai iiieoi?eiaa eeoe, o/anoaiaaaoeo a EIA ia *AYN; ii?aaeaeaiea ?iee e ianoa eo/aauo iaoiaeia aeeaaiinoeee (OCE, ?EA) a eco/aiee iaoiaaiaca oe?aieaeiie iaoieiaee o o/anoieeia EIA; eco/aiea acaeiinaycae yiaeie?eiiie e eiioiiie nenoai a aaiaca oe?aieaeiie iaoieiaee a nia?aiaiiuo ?aaeeaoeeiiii-yeieiae/aneeo oneiaeyo ainoiea Oe?aeiu. I?eiaiaiea eo/aauo in vivo e in vitro iaoiaeia enneaaeiaaiey a eco/aiee iniaaiiinoae aicieeiiaaiey e oa/aiey oe?aieaeiie iaoieiaee o o/anoieeia EIA ia *AYN iieacaei, /oi iniiaiie iaoieiaeae ueoiaeaeiie aeaeacu iinea aa aeeooociiai oaaee/aiey Ia-II no. yaeyaony aooieiioiiue oe?aieaeeo, i?e/ai aai ?ani?ino?aiaiea n?aaee yoie eaoaai?ee iaoeeaioia ni a?aiaiai ?anoao. Oaaee/eaaaony oaeaea e oaeaeueiue aan oceiaiai ciaa. N?iee aicieeiiaaiey oe?aieaeiie (aeeooociie e i/aaiaie) iaoieiaee o o/anoieeia EIA, ii iaoei ?an/aoai, caaenaee io iiiaioa aaa?ee, a oa?aeoa? caaieaaaiee ueoiaeaeiie aeaeacu aue iaoneiaeai i?aauaaieai a ciia aicaeaenoaey eiiece?othuaai eceo/aiey e ae?oaeie yeci- e yiaeiaaiiuie oaeoi?aie. ?aaeeieiioiiue aiaeec ooieoeeiiaeueiie aeoeaiinoe ueoiaeaeiie aeaeacu e aeiioeca?ii-oe?aieaeiuo acaeiiioiioaiee o o/anoieeia EIA ia *AYN n aooieiioiiui oe?aieaeeoii (AEO), oceiaui ciaii (OC) e eeoe n aeeooociui oaaee/aieai ueoiaeaeiie aeaeacu (AeOUAE) naeaeaoaeuenoaoao i iaee/ee eciaiaiee o ii?aaeaeaiiiai /enea iaoeeaioia, eioi?ua i?iyaeythony i?aeiouanoaaiii nieaeaieai o?iaiy T4 i?e ioiineoaeueiie noaaeeueiinoe O3, nieaeaieai niaea?aeaiey OOA e iiauoaieai o?iaiy iiooieaauo ia?ea?ia (OA e ?YA). Aeeiaie/aneia iaaethaeaiea ca yoeie iieacaoaeyie, ia/eiay ni n?iea 6 ian. iinea caaa?oaiey ?aaio a ciia *AYN e aeaeaa a oa/aiea 6-8 eao, naeaeaoaeuenoaoao i iaee/ee iaueo caeiiiia?iinoae i?e eaaeaeii aeaea iaoieiaee ueoiaeaeiie aeaeacu e aa aeeooociii oaaee/aiee Ia-II no.: iiaeuai-iee-nieaeaiea aei ii?iaeueiuo, a aeaeaa aei noaii?iaeueiuo iieacaoaeae. I?e yoii niaea?aeaiea O3 oa?aeoa?eciaaeinue aieueoae noaaeeueiinoueth, a nieaeaiea O4 auei aieaa cia/eiui. Yoa caeiiiia?iinoue, iniaaiii a ioiioaiee nieaeaiey o?iaiy OOA, nio?aiyeanue e aeey o/anoieeia eeeaeaeaoeee iineaaenoaee aaa?ee n eioaeoiie ueoiaeaeiie aeaeacie. Ec yoiai auoaeaao, ai-ia?auo, /oi AeOUAE o o/anoieeia EIA ia *AYN iaeuecy n/eoaoue ii?iaeueiui ninoiyieai, o ii?aaeaeaiiie /anoe iaoeeaioia yoi aeenai?iiiaeueiue oii, ia eioi?ii iiaeao aicieeiooue eaeay-eeai oe?aieaeiay iaoieiaey. Ai aoi?uo, o 39-71 % iaoeeaioia-o/anoieeia eeeaeaeaoeee iineaaenoaee aaa?ee n AeOUAE, AEO, OC ia?yaeo n i?iyaeaieyie noaeeeie/aneiai ia?ae/iiai aeiioe?aica auyaeaiu i?eciaee nieaeaiey oe?aio?iiiie ooieoeee aeiioeca, eioi?ia ni a?aiaiai i?ia?anne?oao. Auyaeaia i?yiay caaeneiinoue iaaeaeo noaiaiueth oaiaoaiey oe?aio?iiiie ooieoeee aeiioeca e aeiciaie iaa?oceie. Yoi iicaieyao aeiionoeoue iaee/ea ?aaeeaoeeiiii iaoneiaeaiiuo i?eciaeia iaoieiaee ueoiaeaeiie aeaeacu e aeiioeca?iie noa?u aneaaenoaea eae aeaenoaey ecioiiia eiaea ia ueoiaeaeioth aeaeaco, oae e aiaoiaai iaeo/aiey iicaa, iai?yiiai ?aaeeaoeeiiiiai aicaeaenoaey e aeaenoaey no?anni?iuo yooaeoia n aeeneii?aeeiaoeeae aeiioaeaii-aeiioeca?iiiaaeii/a/ieeiaie nenoaiu, /oi iiaeao i?eaanoe e noi?annee o?iiiuo ai?iiiia aeiioeca. Iaie onoaiiaeaiu ii?aaeaeaiiua eiioiieiae/aneea ?acee/ey a iaoiaaiaca oe?aieaeiie, a /anoiinoe aooieiioiiie, iaoieiaee o o/anoieeia EIA e aeeoaeae ainoiea Oe?aeiu. Oae, anee o iineaaeieo iaie auyaeaiu eciaiaiey eae O-, oae e A-eeaoi/iiai caaiueaa eiioieoaoa, aeenaaeain a ooieoeeiie?iaaiee eioi?uo iaoneiaeeaaao e iiaeaea?aeeaaao eiioiiiaoieiae/aneee i?ioeann, oi o o/anoieeia EIA i?e iaee/ee iaeioi?uo eciaiaiee ni noi?iiu O-eeaoi/iiai caaia eiioieoaoa aaaeouei yaeyaony iia?aaeaeaiea aoii?aeueiiai caaia. Yoi, i/aaeaeii, naycaii n aeeyieai ?aaeeaoeeiiiiai oaeoi?a eae ia oe?aieaeiua oieeeeoeu e iiin?aaeiaaiii ia nenoaio eiioieoaoa, oae e iaiin?aaenoaaiii ia A-eeioioeeou eae iaeaieaa ?aaeei/oanoaeoaeueiua. Iooai i?eiaiaiey eo/aauo yoi-?aaeeieiioiiuo iaoiaeia enneaaeiaaiey onoaiiaeaiu iaeioi?ua iniaaiiinoe iaoiaaiaca e oa/aiey caaieaaaiee ueoiaeaeiie aeaeacu n?aaee o/anoieeia EIA ia *AYN. N o/aoii auyaeaiiuo iniaaiiinoae i?aaeeiaeaia nenoaia aeeniaina?iiai iaaethaeaiey ca iaoeeaioaie yoie eaoaai?ee. Yoa nenoaia yaeyaony iiiaio?iaiaaie e aace?oaony ia ?aaeaiaioe?iaaiiuo ii a?aiaie aeeniaina?iuo iniio?ao eiioeiaaioa "?enea" e i?eiaiaiee aeeaaiinoe/aneeo enneaaeiaaiee aeey naiaa?aiaiiiai auyaeaiey oe?aieaeiie iaoieiaee, a oii /enea e iieieiae/aneie: OC-iiieoi?eia, ii?aaeaeaiea O4 e OOA, eiioiiiai noaoona, ioieoeeiiiie aeiinee oceiauo ia?aciaaiee ueoiaeaeiie aeaeacu ethaiai aeeaiao?a iiae eiio?ieai OCE ii ?ac?aaioaiiie iaie iaoiaeeea n oeeoieiae/aneei enneaaeiaaieai iieo/aiiiai iaoa?eaea (eioi?iaoeaiinoue - 96%). Oaeei ia?acii, n iiiiuueth eo/aauo in vivo e in vitro iaoiaeia aeeaaiinoeee onoaiiaeaiu iniaaiiinoe iaoiaaiaca caaieaaaiee ueoiaeaeiie aeaeacu, ?ac?aaioaia nenoaia aeeniaina?iiai iaaethaeaiey, iai?aaeaiiay ia oeo/oaiea ea/anoaa aeeaaiinoeee oe?aieaeiie iaoieiaee o o/anoieeia EIA ia *AYN, /oi iicaieyao ii?aaeaeeoue oa?aeoa? ea/aaiie oaeoeee (eiina?aaoeaiay, oe?o?ae/aneay) o aeaiiie eaoaai?ee iaoeeaioia, a oaeaea auaeaeeoue n?aaee ieo a?oiiu "?enea" ii aicieeiiaaieth oe?aieaeiiai ?aea aeey ieieiecaoeee ioaeaeaiiuo noioanoe/aneeo oe?aieaeiuo yooaeoia. Eeth/aaua neiaa: o/anoieee eeeaeaeaoeee iineaaenoaee aaa?ee ia *AYN, aeiioeca?ii-oe?aieaeiay nenoaia, eiioiiue noaoon, oe?aieaeiua caaieaaaiey, eo/aaua iaoiaeu in vivo e in vitro-aeeaaiinoeee, nenoaia aeeniaina?iiai iaaethaeaiey. SUMMARY Afanasyeva N.I. Pathogenetic validation application of radiation diagnosis techniques for dispansery observation of the participants of Chornobyl clean up with throid pathology. - Manuscript. Dissertation for scientific degree of Doctor of Science (Medicine), speciality 14.01.23 - radiodiagnosis and radiotherapy. - Research Institute of Oncology and Radiology, Kyiv, 1999. The dissertation is devoted to an important problem of the study of pathogenetic mechanism of thyroid pathology development in the participants of the Chornobyl accident clean-up using radiological techniques (US, RIA) and working out the system of dispensary observation of these patients to minimise long-term stochastic thyroid effects. The priority direction of radiation medicine, induction of thyroid diseases with 131I with the account of the long-term after-effects of its influence according to the results of monitoring of the persons who participated in the Chornobyl clean-up, deterning the role of radiation (US, RIA) techniques for the study of the pathogenesis of thyroid pathology in the liquidators and in the system of dispensary observation of these patients for timely diagnosis of thyroid diseases as well as the study of interrelations of endocrine and immune systems in the development of thyroid pathology in modern radiation ecological conditions of the East of Ukraine are described. It has been established that the mechanisms of thyroid pathology development in the liquidators and residents of Eastern Ukraine are different and the degree of hormone changes in the liqidators depend on the dose of external irradiation. The data obtained by US and RIA studies about the pathogenetic mechanisms of thyroid diseases in the liquidators were used as the basis of the developed system of dispensary observation of the patients with thyroid pathology which contains therapeutic diagnostic measures and recommendations aimed at timely diagnosis of thyroid pathology (thyroid cancer) to minimise stochastic thyroid effects. The criteria of the risk-group of thyroid diseases formation in the liquidators were developed. Main results of the work were introduced into the practice of dispensary observation of the liquidators with thyroid pathology. Key words: participants of the Chornobyl accident, radiation in vitro and in vivo diagnosis, thyroid diseases, hypophyseal-thyroid system, immune state, dispensary observation system.

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