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Патогенетичне обгрунтування діагностики та лікування гестаційного пієлонефриту: Автореф. дис… канд. мед. наук / В.Ю. Щербаков, Харк. держ. мед. ун-т

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OA?E?ANUeEEE AeA?AEAAIEE IAAeE/iee oi?aa?neoao

Ua?aaeia Aaaeei TH??eiae/

OAeE 618.3-06:616.61-002.3-092

Iaoiaaiaoe/ia iaa?oiooaaiiy ae?aaiinoeee oa e?eoaaiiy aanoaoe?eiiai
i??eiiao?eoo

14.01.01 – aeooa?noai ? a?iaeieia?y

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a –1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii?
ina?oe IIC Oe?a?ie.

Iaoeiaee ea??aiee – aeieoi? iaaee/ieo iaoe, i?ioani? A?euaiei Ieueaa
Aaeaioei?aia, caa?aeoth/a eaoaae?ith ia?eiaoieia?? oa a?iaeieia??
Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe.

Io?oe?ei? iiiiaioe: – aeieoi? iaaee/ieo iaoe, i?ioani? Ua?aeia Ieeiea
Ieaenaiae?iae/, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani?
eaoaae?e aeooa?noaa oa a?iaeieia?? ?1;

– eaiaeeaeao iaaee/ieo iaoe, aeioeaio Eaiaeeaa Ethaeieea ?aai?aia,
Oa?e?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe, aeioeaio eaoaae?e
aeooa?noaa oa a?iaeieia?? ?2.

I?ia?aeia onoaiiaa – ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia??
AII Oe?a?ie, a?aeae?e iaoieia?? aaa?oiino? oa iieia?a.

Caoeno a?aeaoaeaoueny ” 25 ” eenoiiaaea 1999 ?.  i 1130
 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? ?aaee Ae 64.600.01 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a,
i?. Eai?ia, 4).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a, i?. Eai?ia,
4).

Aaoi?aoa?ao ?ic?neaiee ” 14 ” aeiaoiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe, aeioeaio I.I.Oaiueei

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie aeine?aeaeaiiy. A iao?e e?a?i? aeinyaioo? aaeee?
oni?oe a cieaeaii? ia?eiaoaeueii? nia?oiino?, i?ioa, a inoaii? ?iee
i?ioeaio ?? cia/ii i?aeaeueany. Ioaea, cieaeaiiy ia?eiaoaeueii?
nia?oiino? caeeoa?oueny aaaeeeaith i?iaeaiith no/aniiai aeooa?noaa
[A.I.Aaioee?anueeee oa ni?aaao., 1992; A.?.A?euaiei oa ni?aaao., 1993;
E.?.Ooiaiiaa oa ni?aaao., 1996].

Aanoaoe?eiee i??eiiao?eo – iaeia c ?iciianthaeaeaieo aeno?aaai?oaeueieo
caoai?thaaiue i?e aaa?oiino?, iaaaoeaii aieeaath/ee ia
aioo??oiueioo?iaiee ?icaeoie ieiaea, caoai?thaai?noue iiaiia?iaeaeaieo ?
ia?eiaoaeueio nia?oi?noue [E.?.Iiiiia?ueiaa, 1990; TH.N.Ia?auoe oa
ni?aaao., 1996; TH.I.Aaeiae/aiei oa ni?aaao., 1996; I.I.Noaeaeiaa, 1988;
I.I.Oaooiai, 1999].

Aeooaeuei?noue i?iaeaie aecia/a?oueny iaaeoi aenieith /anoioith
aanoaoe?eiiai i??eiiao?eoo, eio?a ca aeaieie ??cieo aaoi??a neeaaea?
a?ae 2,5% aei 12% [A.I.Naaaeue?aa oa ni?aaao., 1991; A.I.Caii?iaeai oa
ni?aaao., 1992; I.N.Ia?aaa?c?a, 1995].

C ianoaiiyi aaa?oiino? ci?ith?oueny ia o?eueee ai?iiiaeueiee noaoon
ae?iee, a ? iiaeeo?eaoe?y ?ioiii? a?aeiia?ae?. Ai?iiiaeueii-?ioiieia?/i?
aca?iia?aeiioaiiy a nenoai? iaoe-ieaoeaioa-ie?ae iiaeooue ii?oooaaoeny,
ui ni?ey? ?icaeoeo ?ioaeoe?eiiai i?ioeano a na/iaea?aeieo oeyoao
[E.A.Oeiioaiei oa ni?aaao., 1990; O.N.Aeno?eoeueea oa ni?aaao., 1996;
I.O.Eaueinueeee oa ni?aaao., 1996].

?aae?caoe?y ?ioiii? a?aeiia?ae? a cia/i?e i??? caeaaeeoue a?ae
no?oeoo?ii-ooieoe?iiaeueii? iiaiioe?iiino? ee?oeiieo iaia?ai.
Aeanoaa?e?caoe?y ee?oeiieo iaia?ai a?ae?a?a? aaaeeeao ?ieue a aaiac?
a?iiene/ieo noai?a ieiaea oa iiaiia?iaeaeaiiai [?.E.I?eieuenueea oa
ni?aaao., 1998].

Iaeiei c i?ioean?a, ui aaaeooue aei aeaci?aai?caoe?? ee?oeiieo iaia?ai,
? ia?aeenia ieeneaiiy e?i?ae?a (IIE).

A?aoiaoth/e iayai?noue ?ioiieia?/iiai aeenaaeaino oa ii?ooaiiy i?ioean?a
IIE-AINC i?e aanoaoe?eiiio i??eiiao?eo?, i/aaeaeia aeioe?euei?noue
i?iaaaeaiiy oa?ai??, ni?yiiaaii? ia ei?aeoe?th aeyaeaieo ii?ooaiue a
nenoai? iaoe-ieaoeaioa-ie?ae [A.I.Ae?aii?e oa ni?aaao., 1990;
A.ss.Aieioa, 1996].

A?eueo?noue ?ia?o a?o/eciyieo oa ca?oa?aeieo aaoi??a a inoaii? ?iee
i?enay/ai? ?ic?iaeai noai, ?aaeei?a aioeaaeoa??aeueii? oa?ai??,
aeicoaaiith i?aia?ao?a i?e e?eoaaii? aanoaoe?eiiai i??eiiao?eoo, aea ia
ooi/iaiith iniaeeainoae eiai iaoiaaiaco oa ee?i?/iiai ia?aa?ao.

E??i oiai, ciaiiy i?i noai iieaciee?a ?ioiiiai, ai?iiiaeueiiai noaoono
oa ?o ei?aeoe??, i?i ci?ie ee?oeiieo iaia?ai i?e aanoaoe?eiiio
i??eiiao?eo? iaei/enaeuei? oa noia?a/i?.

Aeeeaaeai? ianoaaeie aecia/eee aeooaeuei?noue i?iaaaeaiiy
ee?i?ei-?ioiieia?/iiai, ai?iiiaeueiiai aeine?aeaeaiiy, noaio ee?oeiieo
iaia?ai i?e aanoaoe?eiiio i??eiiao?eo? oa ?ic?iaeo aeinooiiiai,
aacia/iiai ?ioiiei?eaoth/iai iaoiaeo e?eoaaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa aeeiiaia o a?aeiia?aeiino? c ?anioae?eainueeith eiiieaeniith
i?ia?aiith “Ioi?iia caei?ia’y iaoa?einoaa oa aeeoeinoaa” oa ieaiii
iaoeiaeo aeine?aeaeaiue eaoaae?e ia?eiaoieia?? oa a?iaeieia??
Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe (?
aea?ae?a?no?aoe?? 0195O020621).

Iaoa aeine?aeaeaiiy.

Iaoa ?iaioe – ooi/ieoe iniaeeaino? iaoiaaiaco aanoaoe?eiiai i??eiiao?eoo
c o?aooaaiiyi noaio ?ioiiiai aiiainoaco, ai?iiiaeueiiai noaoono,
i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a ? aeoeaiino? aioeieneaeaioii?
nenoaie caoenoo, i?aeaeueoe aoaeoeai?noue oa?ai?? i??eiiao?eoo aaa?oieo.

Iniiai? caaea/? aeine?aeaeaiiy.

1. I?iaanoe eiiieaenia aeine?aeaeaiiy ?ioiiiai noaoono ae?iie c
aanoaoe?eiei i??eiiao?eoii, aecia/eoe eiai ?ieue a iaoiaaiac?
caoai?thaaiiy.

2. Aea/eoe noai ia?aeeniiai ieeneaiiy e?i?ae?a ? aioeieneaeaioii?
nenoaie caoenoo a ieaci? e?ia? ae?iie c aanoaoe?eiei i??eiiao?eoii.

3. Aecia/eoe noai ai?iiiaeueiiai noaoono a ianoaaeaieo ae?iie ?
anoaiiaeoe aca?iica’ycie aeyaeaieo ci?i c oa?aeoa?ii ee?i?/ieo i?iya?a.

4. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?ioiiiai, ai?iiiaeueiiai
noaoono oa iieaciee?a ?ioaineaiino? ia?aeeniiai ieeneaiiy e?i?ae?a
aecia/eoe iieacaiiy aei ei?aeoe?? aeyaeaieo ii?ooaiue a eiiieaen?
e?eoaaeueieo caoiae?a aanoaoe?eiiai i??eiiao?eoo.

5. Aea/eoe aieea ?ineeiiiai eiiieaeno a?ieia?/ii aeoeaieo ?a/iaei –
neooaen – ia ?ioiiee noaoon ? i?ioeane IIE-AINC o ae?iie c aanoaoe?eiei
i??eiiao?eoii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa i?iaaaeaii eiiieaenia aeine?aeaeaiiy ?ioiiiai noaoono ae?iie i?e
aanoaoe?eiiio i??eiiao?eo? oa aecia/aia eiai ?ieue a iaoiaaiac?
caoai?thaaiiy.

C’yniaaia ?ieue iaia?aiiaeano?oeoeaieo i?ioean?a i?e i??eiiao?eo?
aaa?oieo.

Anoaiiaeaii aca?iica’ycie aeyaeaieo ci?i ai?iiiaeueiiai noaoono c
oa?aeoa?ii ee?i?/ieo i?iya?a aanoaoe?eiiai i??eiiao?eoo.

Aecia/ai? iieacaiiy aei ei?aeoe?? aeyaeaieo ii?ooaiue ?ioiiiai noaoono ?
i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a i?e aanoaoe?eiiio i??eiiao?eo?.

Iaaeaii iaoeiaa iaa?oiooaaiiy canoinoaaiiy ?ineeiiiai i?aia?aoo neooaen
aeey ei?aeoe?? ii?ooaiue IIE-AINC ? iieaciee?a ?ioiiiai noaoono.

I?aeoe/ia cia/ei?noue iaea?aeaieo ?acoeueoao?a

Aeyaeai? iniaeeaino? ?ioiiiai noaoono i?e ??cieo oi?iao aanoaoe?eiiai
i??eiiao?eoo iathoue nooo?aa cia/aiiy a ioe?ioe? iniaeeainoae
iaoiaaiaco, aeeoa?aioe?eiaaiiai i?aeoiaeo aei i?iaaaeaiiy eiiieaeno
e?eoaaeueii-i?io?eaeoe/ieo caoiae?a ? i?iaiicoaaiiy e?ioey aaa?oiino?.

Aeaia ?iaioa na?ae/eoue i?i cia/ou?noue i?ioean?a ia?aeeniiai ieeneaiiy
e?i?ae?a ? noaio aioeieneaeaioii? nenoaie caoenoo a ?icaeoeo
aanoaoe?eiiai i??eiiao?eoo, a?aee?eaa? iia? oeyoe aeey iaoiaaiaoe/ii
iaa?oioiaaii? oa?ai?? aeaii? iaoieia??.

Ai?iaaaeaeaii iiaee i?aia?ao neooaen, caeaoiee ii?iae?coaaoe
?ioiieia?/i? ii?ooaiiy, ?ia?aoaaoe ia?aeenia ieeneaiiy e?i?ae?a,
ii?iae?coaaoe ooieoe?iiaeueio aeoeai?noue a?iaioeieenethaaeueii?
nenoaie i?e aanoaoe?eiiio i??eiiao?eo?.

Iaoa??aee, ui i?aaenoaaeai? a aeena?oaoe??, aeei?enoai? a oe?ie?e
aeooa?nuee?e i?aeoeoe?.

Iniaenoee aianie caeiaoaa/a

Iaoeia? iieiaeaiiy oa ?acoeueoaoe, ye? aeiinyoueny ia caoeno, iaea?aeai?
aeena?oaioii iniaenoi. A ?iaioao, ui iaae?oeiaai?, aaoi?o iaeaaeeoue
?ic?iaea oa iniaenoa o/anoue a ee?i?ei-eaai?aoi?ieo aeine?aeaeaiiyo. Iei
naiino?eii i?iaiaeeany aiae?c iaea?aeaieo ?acoeueoao?a, ai?iaaaeaeaiiy
?aeiiaiaeaoe?e o a?aeiia?aeiino? c iniiaieie iieiaeaiiyie oa aeniiaeaie
aeena?oaoe??.

Ai?iaaoe?y aeena?oaoe??

Iniiai? iieiaeaiiy aeena?oaoe?? aenoioo? ia I eiia?an? iaiiaoieia?a
Oe?a?ie (Oa?e?a, 1998) ? ia i?aeeaoaae?aeueiiio can?aeaii?
ni?a?ia?oiee?a eaoaae?e ia?eiaoieia?? ? a?iaeieia??, eaoaae?e aeooa?noaa
oa a?iaeieia?? ?1, eaoaae?e aeooa?noaa oa a?iaeieia?? ?2 Oa?e?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe (01.07.1999), a oaeiae ia
can?aeaiiyo iaoeiaiai iaaee/iiai oiaa?enoaa aeooa??a-a?iaeieia?a Oe?a?ie
(1998–1999 ??.).

Ioae?eaoe?? ca oaiith aeena?oaoe??

Ca oaiith aeena?oaoe?? iioae?eiaaii 4 ?iaioe o a?aee?eoiio ae?ooe?, a
oiio /ene? 3 noao? a aeo?iaeao, ui aoiaeyoue aei caoaa?aeaeaiiai AAE
Oe?a?ie ia?ae?eo iaoeiaeo aeaeaiue, a yeeo iiaeooue ioae?eoaaoenue
iniiai? ?acoeueoaoe aeena?oaoe?eieo ?ia?o.

Ia’?i ? no?oeoo?a aeena?oaoe??

Aeena?oaoe?eia ?iaioa, aeeeaaeaia ia 146 noi??ieao ae?oeiaaiiai oaenoo,
neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, i’yoe ?icae?e?a aeanieo
aeine?aeaeaiue, cae?i/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo
e?oa?aoo?e. ?iaioa ?ethno?iaaia 31 oaaeeoeath, 4 iaethieaie, ui
caeiathoue 19 noi??iie. A a?ae?ia?ao?/iiio aeac?aieeo ia 14 noi??ieao
i?eaaaeaii 103 a?o/eciyieo ? 53 ?iicaiieo aeaea?ae.

Iniiaiee ci?no ?IAIOE

Ia’?eo, iaoiaee oa iaoiaeieia?y aeine?aeaeaiiy.

Iaie iiaeai? iaoa??aee eiiieaeniiai ianoaaeaiiy 172 ae?iie. Iniiaio
a?oio neeaee 127 aaa?oieo c ??cieie oi?iaie i??eiiao?eoo: 69 aaa?oieo c
aino?ei ? 58 aaa?oieo c o?ii?/iei i??eiiao?eoii. A eiio?ieueio a?oio
aa?eoee 30 caei?iaeo aaa?oieo ? 15 iaaaa?oieo ae?iie. Ianoaaeai? aaa?oi?
iaee oa?i?i 17–40 oeaei?a aaa?oiino?.

Ca?aeii c ee?i?/iith eeaneo?eaoe??th i??eiiao?eoo, cai?iiiiiaaiith
O.A.Aaciiuaiei (1983), ie c e?eoaaeueii-oaeoe/ieo i??eoaaiue an?
i??eiiao?eoe aaa?oieo ?iciiae?eeee ia “aino??” oa “o?ii?/i?”. Oaeee
?iciiae?e niinoa?aaeaiue aeyaeny aeioe?eueiei aeey iiaeaeueoiai
aeeeaaeaiiy ee?i?/ieo aeine?aeaeaiue, a yeeo ie ni?iaoaaee i?ae?eoe aei
ae??oaiiy iinoaaeaieo a ?iaio? caaea/.

Aaa?oi?, ui ciaoiaeeeenue i?ae iaoei niinoa?aaeaiiyi, ia?aaoaaee ia
aiaoeaoi?iiio oa noaoe?iia?iiio e?eoaaii? a aeooa?nueei-a?iaeieia?/iiio
a?aeae?eaii? OII *a?aiiicaaiaenueeiai ?aeiio i. Oa?eiaa.

Ee?i?/ia ioe?iea na/iaea?aeii? nenoaie i?iaiaeeeanue ia i?aenoaa?
?aoaeueii c?a?aiiai aiaiiaco, ia’?eoeaiiai ianoaaeaiiy oai?eo, aeayeeo
cae/aeieo eaai?aoi?ieo iaoiae?a: ee?i?/iiai aiae?co na/? ii Ia/eii?aiei,
aiae?co e?ia? ia caeeoeiaee acio, ii/aaeio, e?aaoeiei, aeine?aeaeaiiy
caaaeueiiai a?eea ne?iaaoee e?ia? oa eiai o?aeoe?e, i?iae Ceiieoeueeiai,
aeine?aeaeaiiy na/? ia i?e?ioei?o oa /ooeea?noue aei aioea?ioee?a. An?i
ianoaaeaiei aaa?oiei i?iaiaeeeinue oeueo?acaoeiaa aeine?aeaeaiiy ie?ie.

E?eoa??yie iinoaiiaee ae?aaiico i??eiiao?eo aoee eaeeioeeoo??y oa
aaeoa??o??y.

?ioiieia?/iee noaoon ioe?ithaaee ii e?eueeino? iniiaieo iiioeyoe?e ?
noaiiioeyoe?e O- ? A-e?ioioeeo?a oeyoii caoa?aoaaiiy ee?oei a
?ioiioethi?anoeaioiiio oano?, aeei?enoiaoth/e iiiieeiiaeuei? aioeo?ea
aei no?oeoo? iaia?ai NAe3, NAe4, NAe8, NAe16, NAe72. Iiiieeiiaeuei?
aioeo?ea aoee iaea?aeai? a ?ioiieia?/i?e eiiiai?? OIA “Ni?aaio” i.
Iineaa.

Eiioeaio?aoe?th ia?aeiieo i?iaeoeo?a IIE – ae??iiaeo eii’thaao (AeE) a
ieaci? e?ia? aecia/aee ca iaoiaeii A.A.Aaa?eeiaa oa ni?aaao. (1983),
iaeiiiaiai ae?aeueaeaa?aeo (IAeA) – ca iaoiaeii A.I.Ei?iaaeieeiai?
(1989), oaeaee?noue ia?aeeniiai ieeneaiiy e?i?ae?a a a?iiaia?aiao
a?eo?ioeeo?a ? a ieaci? e?ia? – ca iaoiaeii N.I.No?i?aa oa A.A.Iaea?iaa
(1986). Ai?no eaoaeace aecia/aee ca iaoiaeeeith I.I.Ei?iethe oa ni?aao.
(1988), noeueoa?ae?eeuei? a?oie aeine?aeaeoaaee ca iaoiaeii
A.I.Oieiia?aa (1981).

Aeey ioe?iee ai?iiiaeueiiai noaoono aeei?enoiaoaaee iaoiae ai?iiiaeueii?
eieueiioeeoieia?? oa ?aae?i?ioiieia?/iee iaoiae aecia/aiiy ano?aae?ieo,
i?iaanoa?iio, oi??ii?/iiai aiiaaeio?ii?io oa ieaoeaioa?iiai eaeoiaaio.

?acoeueoaoe aeine?aeaeaiue i?aeeyaaeenue noaoenoe/i?e ia?iaoe? c
aeei?enoaiiyi e?eoa??th Nouethaeaioa.

?acoeueoaoe aeanieo aeine?aeaeaiue

I?e aiae?c? iaoa??ae?a ee?i?/ieo niinoa?aaeaiue anoaiiaeaii, ui
a?eueo?noue ae?iie aoee iieiaeiai oa na?aaeiueiai a?eo – 88,9%.

?c iniaeeainoae aiaiiaco i?eaa?oaei oaaao, ui 21 (16,5%) c 127 aaa?oieo
ia?aianea a ieioeiio caoai?thaaiiy ie?ie aai na/iaiai i?oo?a, 29 (22,8%)
ae?iie iaee a?iaeieia?/i? caoai?thaaiiy. O 42 (33,1%) ?c aanoaoe?eiei
i??eiiao?eoii noiooi?i caoai?thaaiiyi aoea a?iio?iiia aiai?y.

I?e oeueo?acaoeia?e ieaoeaioia?ao?? o 53 (44,7%) aaa?oieo c
i??eiiao?eoii aeyaeaia oaoiieaoeaioa?ia iaaeinoaoi?noue.
Oeueo?aniiia?ao?y ie?ie iieacaea ci?ie /aoeiai-ieneiaiai aia?aoo o 10
(8%) ae?iie. ?c 127 aaa?oieo c i??eiiao?eoii o 41 (32,3%) aoea caa?ica
ia?a?eaaiiy aaa?oiino? (o 21 aaa?oii? c aino?ei i??eiiao?eoii ? o 20 – c
o?ii?/iei).

O an?o ae?iie c aanoaoe?eiei i??eiiao?eoii aeyaeaia eaeeioeeoo??y. I?e
aaeoa??ieia?/iiio ianoaaeaii? na/? o 97 aaa?oieo c i??eiiao?eoii
iaea?aeai? oae? ?acoeueoaoe. O 81 (83,5%) aeyaeaia aaeoa??aeueia oei?a,
a o 16 (16,5%) iin?a na/? aoa noa?eeueiei.

Iae/ano?oa aeyaeyeanue eeoeiaa iaee/ea – 62 (76,5%), ??aeoa eeaan??ee,
nei?ai?eia iaee/ea, cieioenoee noao?eieie, aioa?iaaeoa?, i?ioae,
oeeo?iaaeoa?.

I?e e?euee?niiio iaoiae? aecia/aiiy nooiaiy i?e?iaii? eieii?caoe?? na/?
o 33 (34%) aaa?oieo c i??eiiao?eoii ai?no aaeoa??e o na/? aoa
105 EOI/ie, a o 27 (27,8%) oeae iieaciee aoa aeuei.

Aeae?eai? ?c na/? aaa?oieo c i??eiiao?eoii ooaie i?e?ii?aai?ci?a aoee
/ooeea? ia?aaaaeii aei aii?oeee?io, ai?iiae?eiceae?a ? oeaoaeinii??i?a.

I?e an?o oi?iao i??eiiao?eoo aeyaeaia aeeni?ioa?iai?y c ae?aaeaiei
aeao?oeeoii aeueaoi?io.

I?iaaaeaia ?ioiieia?/ia ianoaaeaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii
aeyaeei iaai? a?aeoeeaiiy a?ae oa?aeoa?iiai aeey caei?iaeo aaa?oieo
?ioiiiai noaoono. Oe? ci?ie ae?aaeaeenue ii-??ciiio a caeaaeiino? a?ae
oi?ie i??eiiao?eoo. I?e aino?iio i??eiiao?eo? aaniethoia e?euee?noue ?
i?ioeaioiee ai?no e?ioioeeo?a aoee aeaui ca?eueoai?, i?e o?ii?/iiio –
ciaioai?. I?e aino?iio i??eiiao?eo? a?aei?/aeinue ca?eueoaiiy aeoeaiino?
O-nenoaie ?ioi?oaoo, ia?aaaaeii ca ?aooiie aaniethoiiai ai?noo NAe4+
(0,6±0,02 – i?e aino?iio i??eiiao?eo? oa 0,5±0,03 – a eiio?ieuei?e
a?oi?). I?e ioe?ioe? noaiiioeyoe?eiiai neeaaeo O-ee?oei i?eaa?oaei oaaao
cieaeaiiy eiioeaio?aoe?? ee?oei O-noi?ani?iiai ?yaeo – NAe8+, iaea?eueo
ae?aaeaia i?e o?ii?/iiio i??eiiao?eo? (25,4±1,3% – i?e aino?iio,
23,6±1,1% – i?e o?ii?/iiio i??eiiao?eo?, 26,8±1,3% – a eiio?ie?) oa ca
?aooiie oeueiai a??ia?aeia ca?eueoaiiy ?ioii?aaoeyoi?iiai ?iaeaeno
(1,3±0,04; 1,6±0,03 ? 1,1±0,05, a?aeiia?aeii, ?

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