2

OA?E?ANUeEEE AeA?AEAAIEE IAAeE/iee oi?aa?neoao

Ua?aaeia Aaaeei TH??eiae/

OAeE 618.3-06:616.61-002.3-092

Iaoiaaiaoe/ia iaa?oiooaaiiy ae?aaiinoeee oa e?eoaaiiy aanoaoe?eiiai
i??eiiao?eoo

14.01.01 – aeooa?noai ? a?iaeieia?y

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a –1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii?
ina?oe IIC Oe?a?ie.

Iaoeiaee ea??aiee – aeieoi? iaaee/ieo iaoe, i?ioani? A?euaiei Ieueaa
Aaeaioei?aia, caa?aeoth/a eaoaae?ith ia?eiaoieia?? oa a?iaeieia??
Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe.

Io?oe?ei? iiiiaioe: – aeieoi? iaaee/ieo iaoe, i?ioani? Ua?aeia Ieeiea
Ieaenaiae?iae/, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani?
eaoaae?e aeooa?noaa oa a?iaeieia?? ?1;

– eaiaeeaeao iaaee/ieo iaoe, aeioeaio Eaiaeeaa Ethaeieea ?aai?aia,
Oa?e?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe, aeioeaio eaoaae?e
aeooa?noaa oa a?iaeieia?? ?2.

I?ia?aeia onoaiiaa – ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia??
AII Oe?a?ie, a?aeae?e iaoieia?? aaa?oiino? oa iieia?a.

Caoeno a?aeaoaeaoueny » 25 » eenoiiaaea 1999 ?.  i 1130
 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? ?aaee Ae 64.600.01 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a,
i?. Eai?ia, 4).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a, i?. Eai?ia,
4).

Aaoi?aoa?ao ?ic?neaiee » 14 » aeiaoiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe, aeioeaio I.I.Oaiueei

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie aeine?aeaeaiiy. A iao?e e?a?i? aeinyaioo? aaeee?
oni?oe a cieaeaii? ia?eiaoaeueii? nia?oiino?, i?ioa, a inoaii? ?iee
i?ioeaio ?? cia/ii i?aeaeueany. Ioaea, cieaeaiiy ia?eiaoaeueii?
nia?oiino? caeeoa?oueny aaaeeeaith i?iaeaiith no/aniiai aeooa?noaa
[A.I.Aaioee?anueeee oa ni?aaao., 1992; A.?.A?euaiei oa ni?aaao., 1993;
E.?.Ooiaiiaa oa ni?aaao., 1996].

Aanoaoe?eiee i??eiiao?eo – iaeia c ?iciianthaeaeaieo aeno?aaai?oaeueieo
caoai?thaaiue i?e aaa?oiino?, iaaaoeaii aieeaath/ee ia
aioo??oiueioo?iaiee ?icaeoie ieiaea, caoai?thaai?noue iiaiia?iaeaeaieo ?
ia?eiaoaeueio nia?oi?noue [E.?.Iiiiia?ueiaa, 1990; TH.N.Ia?auoe oa
ni?aaao., 1996; TH.I.Aaeiae/aiei oa ni?aaao., 1996; I.I.Noaeaeiaa, 1988;
I.I.Oaooiai, 1999].

Aeooaeuei?noue i?iaeaie aecia/a?oueny iaaeoi aenieith /anoioith
aanoaoe?eiiai i??eiiao?eoo, eio?a ca aeaieie ??cieo aaoi??a neeaaea?
a?ae 2,5% aei 12% [A.I.Naaaeue?aa oa ni?aaao., 1991; A.I.Caii?iaeai oa
ni?aaao., 1992; I.N.Ia?aaa?c?a, 1995].

C ianoaiiyi aaa?oiino? ci?ith?oueny ia o?eueee ai?iiiaeueiee noaoon
ae?iee, a ? iiaeeo?eaoe?y ?ioiii? a?aeiia?ae?. Ai?iiiaeueii-?ioiieia?/i?
aca?iia?aeiioaiiy a nenoai? iaoe-ieaoeaioa-ie?ae iiaeooue ii?oooaaoeny,
ui ni?ey? ?icaeoeo ?ioaeoe?eiiai i?ioeano a na/iaea?aeieo oeyoao
[E.A.Oeiioaiei oa ni?aaao., 1990; O.N.Aeno?eoeueea oa ni?aaao., 1996;
I.O.Eaueinueeee oa ni?aaao., 1996].

?aae?caoe?y ?ioiii? a?aeiia?ae? a cia/i?e i??? caeaaeeoue a?ae
no?oeoo?ii-ooieoe?iiaeueii? iiaiioe?iiino? ee?oeiieo iaia?ai.
Aeanoaa?e?caoe?y ee?oeiieo iaia?ai a?ae?a?a? aaaeeeao ?ieue a aaiac?
a?iiene/ieo noai?a ieiaea oa iiaiia?iaeaeaiiai [?.E.I?eieuenueea oa
ni?aaao., 1998].

Iaeiei c i?ioean?a, ui aaaeooue aei aeaci?aai?caoe?? ee?oeiieo iaia?ai,
? ia?aeenia ieeneaiiy e?i?ae?a (IIE).

A?aoiaoth/e iayai?noue ?ioiieia?/iiai aeenaaeaino oa ii?ooaiiy i?ioean?a
IIE-AINC i?e aanoaoe?eiiio i??eiiao?eo?, i/aaeaeia aeioe?euei?noue
i?iaaaeaiiy oa?ai??, ni?yiiaaii? ia ei?aeoe?th aeyaeaieo ii?ooaiue a
nenoai? iaoe-ieaoeaioa-ie?ae [A.I.Ae?aii?e oa ni?aaao., 1990;
A.ss.Aieioa, 1996].

A?eueo?noue ?ia?o a?o/eciyieo oa ca?oa?aeieo aaoi??a a inoaii? ?iee
i?enay/ai? ?ic?iaeai noai, ?aaeei?a aioeaaeoa??aeueii? oa?ai??,
aeicoaaiith i?aia?ao?a i?e e?eoaaii? aanoaoe?eiiai i??eiiao?eoo, aea ia
ooi/iaiith iniaeeainoae eiai iaoiaaiaco oa ee?i?/iiai ia?aa?ao.

E??i oiai, ciaiiy i?i noai iieaciee?a ?ioiiiai, ai?iiiaeueiiai noaoono
oa ?o ei?aeoe??, i?i ci?ie ee?oeiieo iaia?ai i?e aanoaoe?eiiio
i??eiiao?eo? iaei/enaeuei? oa noia?a/i?.

Aeeeaaeai? ianoaaeie aecia/eee aeooaeuei?noue i?iaaaeaiiy
ee?i?ei-?ioiieia?/iiai, ai?iiiaeueiiai aeine?aeaeaiiy, noaio ee?oeiieo
iaia?ai i?e aanoaoe?eiiio i??eiiao?eo? oa ?ic?iaeo aeinooiiiai,
aacia/iiai ?ioiiei?eaoth/iai iaoiaeo e?eoaaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa aeeiiaia o a?aeiia?aeiino? c ?anioae?eainueeith eiiieaeniith
i?ia?aiith “Ioi?iia caei?ia’y iaoa?einoaa oa aeeoeinoaa” oa ieaiii
iaoeiaeo aeine?aeaeaiue eaoaae?e ia?eiaoieia?? oa a?iaeieia??
Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe (?
aea?ae?a?no?aoe?? 0195O020621).

Iaoa aeine?aeaeaiiy.

Iaoa ?iaioe – ooi/ieoe iniaeeaino? iaoiaaiaco aanoaoe?eiiai i??eiiao?eoo
c o?aooaaiiyi noaio ?ioiiiai aiiainoaco, ai?iiiaeueiiai noaoono,
i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a ? aeoeaiino? aioeieneaeaioii?
nenoaie caoenoo, i?aeaeueoe aoaeoeai?noue oa?ai?? i??eiiao?eoo aaa?oieo.

Iniiai? caaea/? aeine?aeaeaiiy.

1. I?iaanoe eiiieaenia aeine?aeaeaiiy ?ioiiiai noaoono ae?iie c
aanoaoe?eiei i??eiiao?eoii, aecia/eoe eiai ?ieue a iaoiaaiac?
caoai?thaaiiy.

2. Aea/eoe noai ia?aeeniiai ieeneaiiy e?i?ae?a ? aioeieneaeaioii?
nenoaie caoenoo a ieaci? e?ia? ae?iie c aanoaoe?eiei i??eiiao?eoii.

3. Aecia/eoe noai ai?iiiaeueiiai noaoono a ianoaaeaieo ae?iie ?
anoaiiaeoe aca?iica’ycie aeyaeaieo ci?i c oa?aeoa?ii ee?i?/ieo i?iya?a.

4. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?ioiiiai, ai?iiiaeueiiai
noaoono oa iieaciee?a ?ioaineaiino? ia?aeeniiai ieeneaiiy e?i?ae?a
aecia/eoe iieacaiiy aei ei?aeoe?? aeyaeaieo ii?ooaiue a eiiieaen?
e?eoaaeueieo caoiae?a aanoaoe?eiiai i??eiiao?eoo.

5. Aea/eoe aieea ?ineeiiiai eiiieaeno a?ieia?/ii aeoeaieo ?a/iaei –
neooaen – ia ?ioiiee noaoon ? i?ioeane IIE-AINC o ae?iie c aanoaoe?eiei
i??eiiao?eoii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa i?iaaaeaii eiiieaenia aeine?aeaeaiiy ?ioiiiai noaoono ae?iie i?e
aanoaoe?eiiio i??eiiao?eo? oa aecia/aia eiai ?ieue a iaoiaaiac?
caoai?thaaiiy.

C’yniaaia ?ieue iaia?aiiaeano?oeoeaieo i?ioean?a i?e i??eiiao?eo?
aaa?oieo.

Anoaiiaeaii aca?iica’ycie aeyaeaieo ci?i ai?iiiaeueiiai noaoono c
oa?aeoa?ii ee?i?/ieo i?iya?a aanoaoe?eiiai i??eiiao?eoo.

Aecia/ai? iieacaiiy aei ei?aeoe?? aeyaeaieo ii?ooaiue ?ioiiiai noaoono ?
i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a i?e aanoaoe?eiiio i??eiiao?eo?.

Iaaeaii iaoeiaa iaa?oiooaaiiy canoinoaaiiy ?ineeiiiai i?aia?aoo neooaen
aeey ei?aeoe?? ii?ooaiue IIE-AINC ? iieaciee?a ?ioiiiai noaoono.

I?aeoe/ia cia/ei?noue iaea?aeaieo ?acoeueoao?a

Aeyaeai? iniaeeaino? ?ioiiiai noaoono i?e ??cieo oi?iao aanoaoe?eiiai
i??eiiao?eoo iathoue nooo?aa cia/aiiy a ioe?ioe? iniaeeainoae
iaoiaaiaco, aeeoa?aioe?eiaaiiai i?aeoiaeo aei i?iaaaeaiiy eiiieaeno
e?eoaaeueii-i?io?eaeoe/ieo caoiae?a ? i?iaiicoaaiiy e?ioey aaa?oiino?.

Aeaia ?iaioa na?ae/eoue i?i cia/ou?noue i?ioean?a ia?aeeniiai ieeneaiiy
e?i?ae?a ? noaio aioeieneaeaioii? nenoaie caoenoo a ?icaeoeo
aanoaoe?eiiai i??eiiao?eoo, a?aee?eaa? iia? oeyoe aeey iaoiaaiaoe/ii
iaa?oioiaaii? oa?ai?? aeaii? iaoieia??.

Ai?iaaaeaeaii iiaee i?aia?ao neooaen, caeaoiee ii?iae?coaaoe
?ioiieia?/i? ii?ooaiiy, ?ia?aoaaoe ia?aeenia ieeneaiiy e?i?ae?a,
ii?iae?coaaoe ooieoe?iiaeueio aeoeai?noue a?iaioeieenethaaeueii?
nenoaie i?e aanoaoe?eiiio i??eiiao?eo?.

Iaoa??aee, ui i?aaenoaaeai? a aeena?oaoe??, aeei?enoai? a oe?ie?e
aeooa?nuee?e i?aeoeoe?.

Iniaenoee aianie caeiaoaa/a

Iaoeia? iieiaeaiiy oa ?acoeueoaoe, ye? aeiinyoueny ia caoeno, iaea?aeai?
aeena?oaioii iniaenoi. A ?iaioao, ui iaae?oeiaai?, aaoi?o iaeaaeeoue
?ic?iaea oa iniaenoa o/anoue a ee?i?ei-eaai?aoi?ieo aeine?aeaeaiiyo. Iei
naiino?eii i?iaiaeeany aiae?c iaea?aeaieo ?acoeueoao?a, ai?iaaaeaeaiiy
?aeiiaiaeaoe?e o a?aeiia?aeiino? c iniiaieie iieiaeaiiyie oa aeniiaeaie
aeena?oaoe??.

Ai?iaaoe?y aeena?oaoe??

Iniiai? iieiaeaiiy aeena?oaoe?? aenoioo? ia I eiia?an? iaiiaoieia?a
Oe?a?ie (Oa?e?a, 1998) ? ia i?aeeaoaae?aeueiiio can?aeaii?
ni?a?ia?oiee?a eaoaae?e ia?eiaoieia?? ? a?iaeieia??, eaoaae?e aeooa?noaa
oa a?iaeieia?? ?1, eaoaae?e aeooa?noaa oa a?iaeieia?? ?2 Oa?e?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe (01.07.1999), a oaeiae ia
can?aeaiiyo iaoeiaiai iaaee/iiai oiaa?enoaa aeooa??a-a?iaeieia?a Oe?a?ie
(1998–1999 ??.).

Ioae?eaoe?? ca oaiith aeena?oaoe??

Ca oaiith aeena?oaoe?? iioae?eiaaii 4 ?iaioe o a?aee?eoiio ae?ooe?, a
oiio /ene? 3 noao? a aeo?iaeao, ui aoiaeyoue aei caoaa?aeaeaiiai AAE
Oe?a?ie ia?ae?eo iaoeiaeo aeaeaiue, a yeeo iiaeooue ioae?eoaaoenue
iniiai? ?acoeueoaoe aeena?oaoe?eieo ?ia?o.

Ia’?i ? no?oeoo?a aeena?oaoe??

Aeena?oaoe?eia ?iaioa, aeeeaaeaia ia 146 noi??ieao ae?oeiaaiiai oaenoo,
neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, i’yoe ?icae?e?a aeanieo
aeine?aeaeaiue, cae?i/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo
e?oa?aoo?e. ?iaioa ?ethno?iaaia 31 oaaeeoeath, 4 iaethieaie, ui
caeiathoue 19 noi??iie. A a?ae?ia?ao?/iiio aeac?aieeo ia 14 noi??ieao
i?eaaaeaii 103 a?o/eciyieo ? 53 ?iicaiieo aeaea?ae.

Iniiaiee ci?no ?IAIOE

Ia’?eo, iaoiaee oa iaoiaeieia?y aeine?aeaeaiiy.

Iaie iiaeai? iaoa??aee eiiieaeniiai ianoaaeaiiy 172 ae?iie. Iniiaio
a?oio neeaee 127 aaa?oieo c ??cieie oi?iaie i??eiiao?eoo: 69 aaa?oieo c
aino?ei ? 58 aaa?oieo c o?ii?/iei i??eiiao?eoii. A eiio?ieueio a?oio
aa?eoee 30 caei?iaeo aaa?oieo ? 15 iaaaa?oieo ae?iie. Ianoaaeai? aaa?oi?
iaee oa?i?i 17–40 oeaei?a aaa?oiino?.

Ca?aeii c ee?i?/iith eeaneo?eaoe??th i??eiiao?eoo, cai?iiiiiaaiith
O.A.Aaciiuaiei (1983), ie c e?eoaaeueii-oaeoe/ieo i??eoaaiue an?
i??eiiao?eoe aaa?oieo ?iciiae?eeee ia “aino??” oa “o?ii?/i?”. Oaeee
?iciiae?e niinoa?aaeaiue aeyaeny aeioe?eueiei aeey iiaeaeueoiai
aeeeaaeaiiy ee?i?/ieo aeine?aeaeaiue, a yeeo ie ni?iaoaaee i?ae?eoe aei
ae??oaiiy iinoaaeaieo a ?iaio? caaea/.

Aaa?oi?, ui ciaoiaeeeenue i?ae iaoei niinoa?aaeaiiyi, ia?aaoaaee ia
aiaoeaoi?iiio oa noaoe?iia?iiio e?eoaaii? a aeooa?nueei-a?iaeieia?/iiio
a?aeae?eaii? OII *a?aiiicaaiaenueeiai ?aeiio i. Oa?eiaa.

Ee?i?/ia ioe?iea na/iaea?aeii? nenoaie i?iaiaeeeanue ia i?aenoaa?
?aoaeueii c?a?aiiai aiaiiaco, ia’?eoeaiiai ianoaaeaiiy oai?eo, aeayeeo
cae/aeieo eaai?aoi?ieo iaoiae?a: ee?i?/iiai aiae?co na/? ii Ia/eii?aiei,
aiae?co e?ia? ia caeeoeiaee acio, ii/aaeio, e?aaoeiei, aeine?aeaeaiiy
caaaeueiiai a?eea ne?iaaoee e?ia? oa eiai o?aeoe?e, i?iae Ceiieoeueeiai,
aeine?aeaeaiiy na/? ia i?e?ioei?o oa /ooeea?noue aei aioea?ioee?a. An?i
ianoaaeaiei aaa?oiei i?iaiaeeeinue oeueo?acaoeiaa aeine?aeaeaiiy ie?ie.

E?eoa??yie iinoaiiaee ae?aaiico i??eiiao?eo aoee eaeeioeeoo??y oa
aaeoa??o??y.

?ioiieia?/iee noaoon ioe?ithaaee ii e?eueeino? iniiaieo iiioeyoe?e ?
noaiiioeyoe?e O- ? A-e?ioioeeo?a oeyoii caoa?aoaaiiy ee?oei a
?ioiioethi?anoeaioiiio oano?, aeei?enoiaoth/e iiiieeiiaeuei? aioeo?ea
aei no?oeoo? iaia?ai NAe3, NAe4, NAe8, NAe16, NAe72. Iiiieeiiaeuei?
aioeo?ea aoee iaea?aeai? a ?ioiieia?/i?e eiiiai?? OIA “Ni?aaio” i.
Iineaa.

Eiioeaio?aoe?th ia?aeiieo i?iaeoeo?a IIE – ae??iiaeo eii’thaao (AeE) a
ieaci? e?ia? aecia/aee ca iaoiaeii A.A.Aaa?eeiaa oa ni?aaao. (1983),
iaeiiiaiai ae?aeueaeaa?aeo (IAeA) – ca iaoiaeii A.I.Ei?iaaeieeiai?
(1989), oaeaee?noue ia?aeeniiai ieeneaiiy e?i?ae?a a a?iiaia?aiao
a?eo?ioeeo?a ? a ieaci? e?ia? – ca iaoiaeii N.I.No?i?aa oa A.A.Iaea?iaa
(1986). Ai?no eaoaeace aecia/aee ca iaoiaeeeith I.I.Ei?iethe oa ni?aao.
(1988), noeueoa?ae?eeuei? a?oie aeine?aeaeoaaee ca iaoiaeii
A.I.Oieiia?aa (1981).

Aeey ioe?iee ai?iiiaeueiiai noaoono aeei?enoiaoaaee iaoiae ai?iiiaeueii?
eieueiioeeoieia?? oa ?aae?i?ioiieia?/iee iaoiae aecia/aiiy ano?aae?ieo,
i?iaanoa?iio, oi??ii?/iiai aiiaaeio?ii?io oa ieaoeaioa?iiai eaeoiaaio.

?acoeueoaoe aeine?aeaeaiue i?aeeyaaeenue noaoenoe/i?e ia?iaoe? c
aeei?enoaiiyi e?eoa??th Nouethaeaioa.

?acoeueoaoe aeanieo aeine?aeaeaiue

I?e aiae?c? iaoa??ae?a ee?i?/ieo niinoa?aaeaiue anoaiiaeaii, ui
a?eueo?noue ae?iie aoee iieiaeiai oa na?aaeiueiai a?eo – 88,9%.

?c iniaeeainoae aiaiiaco i?eaa?oaei oaaao, ui 21 (16,5%) c 127 aaa?oieo
ia?aianea a ieioeiio caoai?thaaiiy ie?ie aai na/iaiai i?oo?a, 29 (22,8%)
ae?iie iaee a?iaeieia?/i? caoai?thaaiiy. O 42 (33,1%) ?c aanoaoe?eiei
i??eiiao?eoii noiooi?i caoai?thaaiiyi aoea a?iio?iiia aiai?y.

I?e oeueo?acaoeia?e ieaoeaioia?ao?? o 53 (44,7%) aaa?oieo c
i??eiiao?eoii aeyaeaia oaoiieaoeaioa?ia iaaeinoaoi?noue.
Oeueo?aniiia?ao?y ie?ie iieacaea ci?ie /aoeiai-ieneiaiai aia?aoo o 10
(8%) ae?iie. ?c 127 aaa?oieo c i??eiiao?eoii o 41 (32,3%) aoea caa?ica
ia?a?eaaiiy aaa?oiino? (o 21 aaa?oii? c aino?ei i??eiiao?eoii ? o 20 – c
o?ii?/iei).

O an?o ae?iie c aanoaoe?eiei i??eiiao?eoii aeyaeaia eaeeioeeoo??y. I?e
aaeoa??ieia?/iiio ianoaaeaii? na/? o 97 aaa?oieo c i??eiiao?eoii
iaea?aeai? oae? ?acoeueoaoe. O 81 (83,5%) aeyaeaia aaeoa??aeueia oei?a,
a o 16 (16,5%) iin?a na/? aoa noa?eeueiei.

Iae/ano?oa aeyaeyeanue eeoeiaa iaee/ea – 62 (76,5%), ??aeoa eeaan??ee,
nei?ai?eia iaee/ea, cieioenoee noao?eieie, aioa?iaaeoa?, i?ioae,
oeeo?iaaeoa?.

I?e e?euee?niiio iaoiae? aecia/aiiy nooiaiy i?e?iaii? eieii?caoe?? na/?
o 33 (34%) aaa?oieo c i??eiiao?eoii ai?no aaeoa??e o na/? aoa
105 EOI/ie, a o 27 (27,8%) oeae iieaciee aoa aeuei.

Aeae?eai? ?c na/? aaa?oieo c i??eiiao?eoii ooaie i?e?ii?aai?ci?a aoee
/ooeea? ia?aaaaeii aei aii?oeee?io, ai?iiae?eiceae?a ? oeaoaeinii??i?a.

I?e an?o oi?iao i??eiiao?eoo aeyaeaia aeeni?ioa?iai?y c ae?aaeaiei
aeao?oeeoii aeueaoi?io.

I?iaaaeaia ?ioiieia?/ia ianoaaeaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii
aeyaeei iaai? a?aeoeeaiiy a?ae oa?aeoa?iiai aeey caei?iaeo aaa?oieo
?ioiiiai noaoono. Oe? ci?ie ae?aaeaeenue ii-??ciiio a caeaaeiino? a?ae
oi?ie i??eiiao?eoo. I?e aino?iio i??eiiao?eo? aaniethoia e?euee?noue ?
i?ioeaioiee ai?no e?ioioeeo?a aoee aeaui ca?eueoai?, i?e o?ii?/iiio –
ciaioai?. I?e aino?iio i??eiiao?eo? a?aei?/aeinue ca?eueoaiiy aeoeaiino?
O-nenoaie ?ioi?oaoo, ia?aaaaeii ca ?aooiie aaniethoiiai ai?noo NAe4+
(0,6±0,02 – i?e aino?iio i??eiiao?eo? oa 0,5±0,03 – a eiio?ieuei?e
a?oi?). I?e ioe?ioe? noaiiioeyoe?eiiai neeaaeo O-ee?oei i?eaa?oaei oaaao
cieaeaiiy eiioeaio?aoe?? ee?oei O-noi?ani?iiai ?yaeo – NAe8+, iaea?eueo
ae?aaeaia i?e o?ii?/iiio i??eiiao?eo? (25,4±1,3% – i?e aino?iio,
23,6±1,1% – i?e o?ii?/iiio i??eiiao?eo?, 26,8±1,3% – a eiio?ie?) oa ca
?aooiie oeueiai a??ia?aeia ca?eueoaiiy ?ioii?aaoeyoi?iiai ?iaeaeno
(1,3±0,04; 1,6±0,03 ? 1,1±0,05, a?aeiia?aeii, ?<0,05). Oe?eaai, ui a iaoeo aeine?aeaeaiiyo ia a?aei?/aii nooo?aeo ci?i i?ioeaioiiai ai?noo O-oaeia??a (NAe4+) a caeaaeiino? a?ae oi?ie i??eiiao?eoo. I?e aino?iio i??eiiao?eo? ai?no NAe4+ – 29,9±1,4%, i?e o?ii?/iiio – 28,7±1,2%, a eiio?ie? – 29,4±1,6%. Aeoeai?noue i?e?iaeieo e?ea??a (NAe16+) aoea a??ia?aeii cieaeaia ye i?e aino?iio, oae ? i?e o?ii?/iiio (?<0,05) i??eiiao?eo? o ii??aiyii? c o?c?ieia?/iith aaa?oi?noth. I?e oeueiio aaaeeeai i?iaiae?coaaoe aeaa iiiaioe. Ii-ia?oa, iacaaaeath/e ia cieaeaiiy O-noi?ani??a (NAe8+), iniaeeai ae?aaeaia i?e o?ii?/iiio i??eiiao?eo?, nooi?iue cieaeaiiy iieacieea o ii??aiyii? c eiio?ieueiith a?oiith neeaaeaea 1,7 ?ace. A oie aea /an, a a?oi? aaa?oieo c aino?ei i??eiiao?eoii ae?aaeai?noue ci?i ia ia?aaeuoaaea 1,1 ?ace. Ii-ae?oaa, i?e o?ii?/iiio i??eiiao?eo? i?ioeaio i?e?iaeieo e?ea??a (NAe16+) a 1,4 ?ace ieae/a, i?ae i?e o?c?ieia?/i?e aaa?oiino? (0,12±0,04 ? 0,17±0,02, a?aeiia?aeii), i?e aino?iio i??eiiao?eo? i?ioeaio NAe16+ aoa a 1,2 ?ace ieae/a, i?ae a eiio?ie? (0,14±0,03 ? 0,17±0,02, a?aeiia?aeii). Na?aae ?ioeo ci?i iaiao?aeii a?aei?oeoe ca?eueoaiiy o ae?iie c aino?ei i??eiiao?eoii iieacieea ni?aa?aeiioaiiy O/A e?ioioeeo?a, yea, i/aaeaeii, yaeeinue iane?aeeii ia o?eueee ci?ie ai?noo O-e?ioioeeo?a (NAe3+) aea ? cieaeaiiy eiioeaio?aoe?? A-e?ioioeeo?a (NAe72+). Iaie a?aei?/aii oaeiae i?ioeaioia ca?eueoaiiy O/A-e?ioioeeo?a i?e o?ii?/iiio i??eiiao?eo? ca ?aooiie cieaeaiiy ye NAe3+, oae ? NAe72+. Iaea?aeai? aeai? i?aeoaa?aeaeothoue aeoieo ?ioeo aeine?aeiee?a, ui iieaciee ni?aa?aeiioaiiy O/A-e?ioioeeo?a ?, cie?aia, eiai ca?eueoaiiy, iiaea aooe aeei?enoaiee ye ?ioi?iaoeaiee oano ?icaeoeo aaa?oiino?. Eiioeaio?aoe?y IgG i?e aino?iio aanoaoe?eiiio i??eiiao?eo? aoea cieaeaia, a Ig A oa IgM iaea oaiaeaioe?th aei i?aeaeuaiiy o ii??aiyii? c o?c?ieia?/ii ia?aa?aath/ith aaa?oi?noth (IgG – 12,6±0,9 a/e; IgA – 1,88±0,35 a/e; IgM – 1,63±0,24 a/e) ? a eiio?ie? (a?aeiia?aeii 17,51±1,1 a/e, 1,59±0,07 a/e, 1,12±0,33 a/e), ui iiaea aooe iaei??th c i?e/ei ?ioaeoe?eii-caiaeueiiai caoai?thaaiiy ie?ie. I?e o?ii?/iiio i??eiiao?eo? a?aei?/aii cieaeaiiy an?o eean?a ?ioiiaeiaoe?i?a, ui aeaco? ia iayai?noue ?ioiiaeao?oeeoo (IgA – 1,88±0,35 a/e; IgM – 1,63±0,24 a/e; IgG – 12,6±0,9 a/e ? a eiio?ie?, a?aeiia?aeii, 1,59±0,07 a/e; 1,12±0,33 a/e; 17,51±1,12 a/e). ??aaiue e?ioioeeoioiene/ieo aeeiaioeo?e a ne?iaaooe? e?ia? aaa?oieo c o?ii?/iei i??eiiao?eoii aoa o?ioe aeua aeaiiai iieacieea a eiio?ieuei?e a?oi? (18,9±2,1% ? 13,2±1,4%), a aaoa?io?eueieo aaiie?c?i?a, oi/ ? iaa a??ia?aeio ??cieoeth (?<0,05), aea nooi?iue ?? aoea iaaenieith. Oe? iieacieee iaeoee oe?iea canoinoaaiiy a ee?i?oe? ye “aeni?an-iaoiaee” ae?aaiinoeee iaa?oue iacia/ieo ci?i ?ioiiiai aiiainoaco. Oaeei /eiii, iiaeia a?aei?oeoe, ui iaoai?ci ?ioiieo aca?iiae?e i?e aaa?oiino?, iaa?oue o?c?ieia?/ii ia?aa?aath/?e, aeinoaoiuei neeaaeiee, iniaeeai i?e ??ciee iaoieia?? aaa?oiino?, iaoiiaeai?e ?icaaeainoaaiiyi oaeiai ?iaeo aca?iiae?e. Ca?aene noa? i/aaeaeiei, ui a caeaaeiino? a?ae ao?ieia?/ieo oaeoi??a iiaeooue ii-??ciiio ci?ithaaoenue iieacieee, ui oa?aeoa?ecothoue ?ioiio nenoaio. I?ioa, ia aeeeth/aii, ui iaaia nooi?iue ?io?eiaaiino? i?e aanoaoe?eiiio i??eiiao?eo? ? ni?ey? aeenooieoe?? ?ioiii? nenoaie i?e aino?iio i??eiiao?eo? oa i?eai?/aiith oaeoi??a ?ioi?oaoo i?e o?ii?/iiio i??eiiao?eo?. I?e aeine?aeaeaii? iieaciee?a IIE-AINC o ae?iie c aanoaoe?eiei i??eiiao?eoii aeyaeaii, ui ai?no AeE o aaa?oieo c aino?ei i??eiiao?eoii iacia/ii a?ae??ciy?oueny a?ae caei?iaeo aaa?oieo (1,29±0,01 oiia. iae. iio. u?euei. ? 1,02±0,2 oiia. iae. iio. u?euei.), o aaa?oieo c o?ii?/iei i??eiiao?eoii a?i a??ia?aeii aeuee (1,63±0,02 oiia. iae. iio. u?euei., a eiio?ie? – 1,02±0,01 oiia. iae. iio. u?euei., P<0,05). Ai?no IAeA aoa i?aeaeuaiee a iaio a?oiao, aea iaea?eueo ae?aaeaiee a?i aoa i?e o?ii?/iiio i??eiiao?eo? (8,27±0,03 ieiieue/e i?e o?ii?/iiio i??eiiao?eo?; 6,12±0,04 ieiieue/e i?e aino?iio ? 5,65±0,03 ieiieue/e a eiio?ie?, P<0,05). Oaeaee?noue ?iaeoeoe?eiaaiiai ieeneaiiy e?i?ae?a (?OIE) ? niiioaiiiai ieeneaiiy e?i?ae?a (?NIE) o aaa?oieo c o?ii?/iei i??eiiao?eoii ca?eueoaia ye a ieaci? (a 2,6 ? 2,7 ?ace, a?aeiia?aeii), oae ? a a?eo?ioeeoao (a 3,1 ? 3,5 ?ace, a?aeiia?aeii) o ii??aiyii? c a?oiith caei?iaeo aaa?oieo. E??i oeueiai, ?ioaineai?noue i?ioean?a IIE a a?eo?ioeeoao aaa?oieo c o?ii?/iei i??eiiao?eoii aeua, i?ae o ieaci?. O aaa?oieo c aino?ei i??eiiao?eoii a?aei?/aeinue ca?eueoaiiy ?OIE ? NOIE ye a ieaci?, oae ? a a?eo?ioeeoao (a 1,6 ? 1,3 ?ace a ieaci? oa a 1,3–1,4 ?ace a a?eo?ioeeoao, a?aeiia?aeii) o ii??aiyii? c eiio?ieueiith a?oiith. Aea/aiiy ai?noo “caoeniiai oa?iaioo” – eaoaeace – o ae?iie c aanoaoe?eiei i??eiiao?eoii iieacaei ?? cieaeaiiy a 1,6 ?ace i?e aino?iio ? a 1,8 ?ace i?e o?ii?/iiio i??eiiao?eo?. O e?ia? aaa?oieo c aino?ei ? o?ii?/iei i??eiiao?eoii a?aei?/aeinue a??ia?aeia (P<0,05) cieaeaiiy caaaeueieo noeueoa?ae?eeueieo a?oi o ii??aiyii? c ?o e?euee?noth o caei?iaeo aaa?oieo. ?acoeueoaoe aeine?aeaeaiue iieacaee, ui aanoaoe?eiee i??eiiao?eo noi?iaiaeaeo?oueny i?aeaeuaiiyi o e?ia? oiene/ieo i?iaeoeo?a ia?ieneaeaoe??, o ii??aiyii? c o?c?ieia?/ii ia?aa?aath/ith aaa?oi?noth, yea iaea?eueo ae?aaeaia o aaa?oieo c o?ii?/iei i??eiiao?eoii. E??i oeueiai, a e?ia? ae?iie c aanoaoe?eiei i??eiiao?eoii aeoeai?noue AINC cieaeaia o ii??aiyii? ?c caei?iaeie aaa?oieie. I?iaaaeaia aeine?aeaeaiiy eiioeaio?aoe?? ano?aae?ieo, i?iaanoa?iio, OA ? IE iieacaei, ui o aaa?oieo c aanoaoe?eiei i??eiiao?eoii a?aei?/a?oueny cieaeaiiy ??aiy aeaio ? a?eueoa ai?iii?a ia iaeia n?aiaeueia a?aeoeeaiiy, iaea?eueo ae?aaeaia i?e o?ii?/iiio i??eiiao?eo?. sse iieacaa ?iaeea?aeoaeueiee aiae?c, i?iaiinoe/ii iani?eyoeeaei aoei cieaeaiiy i?iaanoa?iio ? IE ia 2–3 n?aiaeueieo a?aeoeeaiue. Iaoieia?/i? oeie eieueiioeeoia?ai aeyaeai? o 41 (32,3%) ?c 127 ae?iie c aanoaoe?eiei i??eiiao?eoii, ui aeacoaaei ia iaiao?aei?noue aeeth/aiiy ai?iiiaeueiiai eiiiiiaioa a eiiieaenia e?eoaaiiy oeeo aaa?oieo. Oaeei /eiii, iaea?aeai? ?acoeueoaoe aeine?aeaeaiiy aaa?oieo c i??eiiao?eoii aeicaieythoue c?iaeoe aeniiaie, ui a i?aai?ci? oeeo aaa?oieo a?aeaoaathoueny i?ioeane, ye? a?ae??ciythoueny a?ae oaeeo i?e o?c?ieia?/iiio ia?aa?ao aanoaoe??. I?aeoaa?aeaeaiiyi oeueiio neoaeaoue ci?ie iieaciee?a ?ioiiiai noaoono, ca?eueoaiiy ooai?aiiy ae??iiaeo eii’thaao, iaeiiiaiai ae?aeueaeaa?aeo, i?enei?aiiy ?iaeoeoe?eiaaiiai oa niiioaiiiai ieeneaiiy e?i?ae?a, cieaeaiiy ai?noo eaoaeace oa caaaeueieo noeueoa?ae?eeueieo a?oi, ai?iiiaeueiee aeenaaeain. I?e oeueiio a?aeoeeaiiy iaea?eueo ae?aaeai? o aaa?oieo c o?ii?/iei i??eiiao?eoii. Ana aeuaaeeeaaeaia aeeeooaaei iaiao?aei?noue iiooeo e?eoaaeueieo i?aia?ao?a, ui aieiae?thoue iaeii/anii ?ioiiei?eaoth/eie aeanoeainoyie oa a?aeiiaeththoue ii?ooaio ooieoe?th ee?oeiieo iaia?ai. A oeueiio ieai? iniaeeao oaaao aeooa??a-a?iaeieia?a a inoaii? ?iee i?eaa?oathoue ?ineeii? i?aia?aoe. Iaie i?iaaaeaii aea/aiiy e?eoaaeueiiai iioaioe?aeo i?aia?aoo neooaen, yeee i?aaenoaaey? niaith nooee aeno?aeo oeueiiieea aaeeaeuenueeiai a oaaeaoeao (Tabulette Extractum Scutellaris Baicelensis siccum obductae). I?aia?ao neioaciaaii a Aea?aeaaiiio iaoeiaiio oeaio?? e?ea?nueeeo cania?a (AeIOeEC) ? caoaa?aeaeaii Oa?ieii?oaoii IIC Oe?a?ie. Ei?aeoe?y iieaciee?a ?ioiiiai noaoono oa IIE-AINC i?iaiaeeeanue oeyoii aeeth/aiiy a eiiieaenia e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii i?aia?aoo neooaen ii 1 oaaeaooe? (0,05 a) 3 ?ace a aeaiue i?ney ?ae? ai?iaeiaae 14 aei?a. I?e a?aenooiino? aoaeoo eo?n e?eoaaiiy i?iaeiaaeoaaee aei 28 aei?a. Iaie i?iaaaeaii e?eoaaiiy 127 ae?iie: 69 ae?iie c aino?ei aanoaoe?eiei i??eiiao?eoii ? 58 aaa?oieo c o?ii?/iei i??eiiao?eoii, ye? iaae?eoee ia e?eoaaiiy i?e oa?i?i? aaa?oiino? 17–38 oeaei?a. I?eioeeie eiiieaeniiai e?eoaaiiy aaa?oieo c i??eiiao?eoii aeeoa?aioe?thaaeenue a caeaaeiino? a?ae oyaeeino? caoai?thaaiiy, noaae?? i?ioeano, oa?i?io aaa?oiino?, aeaeo caoaeieea, noaio aioo??oiueioo?iaiiai ieiaea. Oa?ai?y i??eiiao?eoo aoea ?aiiueith oa eiiieaeniith. Iaoith ?? yaeyeanue iaeneiaeueii oaeaeea e?ea?aeaoe?y caiaeueiiai i?ioeano a na/iaea?aeieo oeyoao, ciyooy ?ioieneeaoe??, ii?iae?caoe?y aeaeo?ie?oieo ii?ooaiue, a?aeiiaeaiiy aeeiai?ee na/iaea?aeieo oeyo?a, i?io?eaeoeea oneeaaeiaiue aaa?oiino?. I?e aino?iio i??eiiao?eo? aaa?oieo ia?aaaao iaaeaaaee iai?oeee?io, aii?oeee?io, aaioai?oeeio, ienaoeee?io, aeeeeienaoeee?io. O aeiaaeeo oyaeeiai ia?aa?ao i??eiiao?eoo canoiniaoaaee aioea?ioeee oe?ieiai niaeo?o ae?? c a?oie oeaoaeinii?ei?a. I?e iaaoaeoeaiino? iiiioa?ai??, a oaeiae ci?oai?e ?ioaeoe?? i?ecia/aee eiia?iaoe?th aioeaaeoa??aeueieo i?aia?ao?a. A ?ac? eaaeiai ia?aa?ao aanoaoe?eiiai i??eiiao?eoo canoiniaoaaee i?aia?aoe i?o?ioo?aiiaiai ?yaeo.. O eiiieaenia e?eoaaiiy aeeth/aee aeac?ioieneeaoe?ei? caniae, aioea?noai?ii? i?aia?aoe, niaciie?oe/i? caniae, a?oai?ie oa ?o iio?aei?. Oa?ai?th aino?iai ? o?ii?/iiai i??eiiao?eoo aaa?oieo i?iaiaeeee ia?a?ea/anoeie eo?naie o?eaae?noth a na?aaeiueiio 2–3 oeaei?. O ca’yceo c aeyaeaieie ci?iaie a ?ioii?e nenoai? oa ii?ooaiiyie IIE-AINC an?i ae?ieai c aanoaoe?eiei i??eiiao?eoii, e??i o?aaeeoe?eiiai e?eoaaiiy, i?ecia/aee i?aia?ao neooaen. 41 (32,3%) aaa?oi?e c i??eiiao?eoii oa c caa?icith ia?a?eaaiiy aaa?oiino? i?iaiaeeeanue ai?iiiioa?ai?y. O aeiaaeeo oaoiieaoeaioa?ii? iaaeinoaoiino? i?ecia/aee a?aeiia?aeia e?eoaaiiy. Ia?aae oa i?ney e?eoaaiiy ae?ieai c aanoaoe?eiei i??eiiao?eoii i?iaiaeeeinue ?ioiieia?/ia, ai?iiiaeueia ianoaaeaiiy, aeine?aeaeaiiy i?ioean?a IIE-AINC. ?acoeueoaoe aeine?aeaeaiiy iieaciee?a ee?oeiiiai ?ioi?oaoo o ae?iie c aanoaoe?eiei i??eiiao?eoii a i?ioean? e?eoaaiiy i?aaenoaaeai? a oaaeeoe? 1. I?e aiae?c? ?iciiae?eaiiy iieaciee?a ee?oeiiiai ?ioi?oaoo i?ney i?iaaaeaiiai e?eoaaiiy c aeeth/aiiyi i?aia?aoo neooaen noa? i/aaeaeiei aeaa oaeoe. Ii-ia?oa, ii a?eueoino? ia?aiao??a ca?eueoo?oueny /enei ae?iie c iieacieeaie, ui aei??aiththoue ii?i?. E??i oeueiai, ynii, ui oaea ca?eueoaiiy a iniiaiiio aeieea? ca ?aooiie ia?aaaaeieo ci?i (ii?iae?caoe??) ia iaeiiai iieacieea, a aeaio ? a?eueoa iaeii/anii. Aaaeeeaei ? oie oaeo, ui ia o?eueee yeanue /enei ae?iie ii a?aeiia?aeiei iieacieeai ia?aeoee a a?oio c ii?iaeueiei ?o cia/aiiyi, ye ? i?e o?c?ieia?/i?e aaa?oiino?, aea ? a a?oiao, ui caeeoeeenue c iaioeie aai a?eueoeie iieacieeaie, inoaii? ci?ithaaeenue o e?auo noi?iio. Aeeeth/aiiy neeaaeaee NAe16+ ee?oeie, na?aaei?e iieaciee yeeo i?e aino?iio i??eiiao?eo? ia?aaeuoaaa iieaciee eiio?ieueii? a?oie, i?e o?ii?/iiio i??eiiao?eo? a?i aoa aeae?eueea ieae/ee (9,6±1,2: i?e aino?iio i??eiiao?eo?, 8,8±1,1% i?e o?ii?/iiio, 9,7±1,1 a eiio?ie?). Na?aae ?ioeo iieaciee?a iaiao?aeii a?aei?oeoe ci?io i?ney e?eoaaiiy ni?aa?aeiioaiiy O/A-e?ioioeeo?a (6,5±0,3 i?e aino?iio i??eiiao?eo?, 6,1±0,2 i?e o?ii?/iiio i??eiiao?eo? ? 6,3±0,2 a eiio?ieuei?e a?oi?). Aiae?c ?acoeueoao?a eiiieaeniiai e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii c aeeth/aiiyi i?aia?aoo neooaen iieacaa, ui eiioeaio?aoe?y Ig A oa Ig M ca?eueooaaeenue, ia?aaeuoth/e iieacieee eiio?ieueii? a?oie, a ai?no Ig G oi/ ? ca?eueooaaany, aea caeeoaany ieae/a iieacieea caei?iaeo aaa?oieo. I?ney i?iaaaeaiiai e?eoaaiiy cieaeoaaany i?ioeaio e?ioioeeoioiene/ieo aeeiaioeo?e ? aaoa?io?eueieo aaiie?cei?a, iaaeeaeath/enue aei iieaciee?a i?e o?c?ieia?/i?e aaa?oiino?. Oaaeeoey 1 Iieacieee ee?oeiiiai ?ioi?oaoo o ae?iie c aanoaoe?eiei i??eiiao?eoii i?ney e?eoaaiiy (M±m) IieacieeeA?oie ianoaaeaieoO?c?ieia?/ia aaa?oi?noue (I a?oia)Aaa?oi? c aino?ei i??eiiao?eoii (II a?oia)Aaa?oi? c o?ii?/iei i??eiiao?eoii (III a?oia)aei e?eoaaiiyi?ney e?eoaaiiyaei e?eoaaiiyi?ney e?eoaaiiyEaeeioeeoe o1096,7±0,57,2±0,17,5±0,66,6±0,46,8±0,3E?ioioeeoe o109 % 1,9±0,08 27,4±0,9 2,1±0,06 28,3±0,5 1,9±0,04 28,2±0,7 1,8±0,05 26,3±0,8 1,9±0,04 27,8±0,6Iiioeyoe?? oa noaiiioeyoe?? e?ioioeeo?aNAe3+ o 109 %1,0±0,03 57,2±2,41,2±0,04 59,1±1,71,3±0,02 56,4±1,3*0,8±0,04 55,6±1,90,9±0,05 56,9±1,8*NAe4+ o 109 %0,5±0,03 29,4±1,60,6±0,02 29,9±1,40,59±0,01 28,3±1,50,47±0,04 28,7±1,20,5±0,04 29,1±1,1NAe8+ o 109 %0,48±0,01 26,8±1,30,47±0,02 25,4±1,30,48±0,01 26,1±1,20,29±0,03 23,6±1,10,39±0,02 25,2±1,3NAe16+ o 109 %0,17±0,02 9,7±1,10,14±0,03 8,2±1,30,18±0,01* 9,6±1,20,12±0,04 7,1±0,90,16±0,03* 8,8±1,1NAe72+ o 109 %0,16±0,02 7,8±0,40,15±0,02 7,3±0,30,2±0,01 8,3±0,2*0,14±0,01 6,2±0,30,15±0,02 7,6±0,1*??? 1,1±0,051,3±0,041,2±0,03*1,6±0,031,3±0,02*O/A o 109 %6,3±0,2 7,3±0,38,0±0,1 8,1±0,26,5±0,3 6,8±0,15,7±0,3 8,9±0,16,1±0,2 7,8±0,4I?ei?oea: * – p<0,05 o ii??aiyii? c iieacieeaie I a?oie. Iaie i?iaaaeaii aeine?aeaeaiiy ia?aeeniiai ieeneaiiy e?i?ae?a o a?oi? ianoaaeaieo ae?iie a i?ioean? e?eoaaiiy (oaaeeoey 2). Oaaeeoey 2 Ai?no AeE ? IAeA a ieaci? e?ia? oa ?OIE–NOIE a ieaci? oa a?eo?ioeeoao a i?ioean? e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii (M±m) Iieacieee ia?aeeniiai ieeneaiiy e?i?ae?aAaa?oi? c aino?ei i??eiiao?eoiiAaa?oi? c o?ii?/iei i??eiiao?eoiiAei e?eoaaiiyAeE, oiia. iae. iio. u?euei.1,29±0,011,63±0,02IAeA, ieiieue/ie6,12±0,048,27±0,03?OIE a ieaci?, IAe/aiae16,78±0,8228,04±1,41?OIE a a?eo?ioeeoao, IAe/aiae17,03±0,5638,72±0,74NOIE a ieaci?, IAe/aiae14,48±0,5729,83±0,32NOIE a a?eo?ioeeoao, IAe/aiae18,94±0,3247,36±0,03I?ney e?eoaaiiyAeE, oiia. iae. iio. u?euei.0,93±0,010,98±0,03IAeA, ieiieue/ie5,42±0,035,61±0,04?OIE a ieaci?, IAe/aiae10,05±1,1410,11±1,22?OIE a a?eo?ioeeoao, IAe/aiae12,32±1,0112,40±1,05NOIE a ieaci?, IAe/aiae12,04±0,0311,09±0,37NOIE a a?eo?ioeeoao, IAe/aiae13,21±0,0612,94±0,08 I?ei?oea: P<0,05 o ii??aiyii? c iieacieeaie aei e?eoaaiiy. O ?acoeueoao? i?iaaaeaiiai e?eoaaiiy aeieeei oiia?eueiaiiy i?ioean?a IIE (a??ia?aeia cieaeaiiy iieaciee?a AeE ? IAeA, a oaeiae ?OIE ? NOIE ye o ieaci?, oae ? a a?eo?ioeeoao (P<0,05). Aeoeai?noue eaoaeace i?ney i?iaaaeaiiai e?eoaaiiy a??ia?aeii i?aeaeuoaaeanue o an?o aaa?oieo c aanoaoe?eiei i??eiiao?eoii, aeinyaath/e iaea?eueo aeniei? aeoeaiino? o aaa?oieo c o?ii?/iei i??eiiao?eoii (14,05±0,15 ieao/e – aei e?eoaaiiy ? 26,32±0,13 ieao/e – i?ney e?eoaaiiy i?e o?ii?/iiio i??eiiao?eo?; 16,02±0,13 ieao/e aei e?eoaaiiy ? 24,37±0,14 ieao/e i?ney e?eoaaiiy i?e aino?iio i??eiiao?eo?, P<0,05). Aiaeia?/i? eaoaeac? ci?ie a i?ioean? e?eoaaiiy niinoa??aaeenue ? o ai?no? caaaeueieo noeueoa?ae?eeueieo a?oi (1,34±0,02 iiieue/e ? 1,02±0,03 iiieue/e aei e?eoaaiiy a iaio a?oiao aaa?oieo c i??eiiao?eoii; 2,32±0,05 iiieue/e ? 2,69±0,04 iiieue/e i?ney e?eoaaiiy, a?aeiia?aeii, P<0,05). Oaeei /eiii, a ?acoeueoao? eiiieaeniiai e?eoaaiiy aaa?oieo c i??eiiao?eoii c aeeth/aiiyi i?aia?aoo neooaen aeieeaei oiia?eueiaiiy i?ioean?a IIE, cieaeaiiy oiene/ieo i?iaeoeo?a ia?ieneaeaoe?? oa aeoeaaoe?y aioeieneaeaioii? nenoaie caoenoo. I?iaaaeaia aeine?aeaeaiiy ano?aae?ieo, i?iaanoa?iio, OA ? IE a i?ioean? e?eoaaiiy o 21 aaa?oii? c aino?ei i??eiiao?eoii ? o 20 ae?iie c o?ii?/iei i??eiiao?eoii (oaaeeoey 3) oa ?c caa?icith ia?a?eaaiiy aaa?oiino? iieacaei, ui aeieeaea a?aeiinia ii?iae?caoe?y oeeo iieaciee?a, ui aeacoaaei ia aeoeaaoe?th eiiiainaoi?ieo iaoai?ci?a, ui caaacia/othoue ai?iiiaeueio ooieoe?th ieaoeaioe (oaaeeoey 3). I?iaiinoe/ii iani?eyoeeaei aoei cieaeaiiy i?iaanoa?iio oa IE ia 2–3 n?aiaeueieo a?aeoeeaiue. Ca iaoeie aeaieie, i?aeoe/ii o an?o ae?iie c aanoaoe?eiei i??eiiao?eoii aeieeei /a?aoaaiiy noaio caa?iaeoth/iai aeeeaeiy oa i/aaeaeiiai aeaaiiieo//y a ia?aa?ao aaa?oiino?. O ca’yceo c oeei ianoaaeaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii iaiao?aeii i?iaiaeeoe i?ae /an aaa?oiino? ua aei iiyae ee?i?/ii? neiioiiaoeee caa?ice ia?a?eaaiiy aaa?oiino?, uia nai?/anii i?iaanoe i?io?eaeoe/ia e?eoaaiiy. Iieacaiiyi aei i?io?eaeoe/iiai e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii, iaa?oue i?e a?aenooiino? o ieo ia iiiaio ianoaaeaiiy ee?i?/ii? ea?oeie caa?ice ia?a?eaaiiy aaa?oiino?, yaeythoueny ne?aeoth/? ci?ie: cieaeaiiy ai?noo NAe8+ ? NAe16+ ee?oei, i?aeaeuaiiy ??aiy e?ioioeeoioiene/ieo aeeiaioeo?e ? aaoa?io?eueieo aaiie?cei?a, ?ioaineo?eaoe?y i?ioean?a IIE ? cieaeaiiy aeoeaiino? AINC, iiyaa iaoieia?/ieo oei?a eieueiioeeoia?ai. Oaaeeoey 3 Ai?no ano?aae?ieo, i?iaanoa?iio, OA ? IE o e?ia? ae?iie c aanoaoe?eiei i??eiiao?eoii aei oa i?ney e?eoaaiiy (M±m) IieacieeeAaa?oi? c aino?ei i??eiiao?eoiiAaa?oi? c o?ii?/iei i??eiiao?eoii16–28 oeaei?a28–36 oeaei?a16–28 oeaei?a28–36 oeaei?aAei e?eoaaiiyAno?aae?ie, ia/ie11,36±0,1215,71±0,639,74±0,3612,63±0,18I?iaanoa?ii, ia/ie27,81±1,0435,96±1,0925,02±0,9724,91±1,02OA, II/ie21,3±1,0924,5±3,2719,07±1,1422,4±3,01IE, iea/ie2,04±0,256,95±0,821,44±0,374,82±0,76I?ney e?eoaaiiyAno?aae?ie, ia/ie10,27±0,1414,95±0,4310,94±0,2711,62±0,06I?iaanoa?ii, ia/ie26,97±1,0233,94±1,0127,73±0,9533,84±1,05OA, II/ie20,31±1,0423,87±2,1420,2±1,1723,05±2,04IE, iea/ie2,45±0,736,35±0,592,3±0,365,94±0,87 Aiae?c ?acoeueoao?a niinoa?aaeaiue iieacaa, ui aeeoa?aioe?eiaaiee i?aeo?ae aei e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii c aeeth/aiiyi i?aia?aoo neooaen, ui aieiae?? ?ioiiei?eaoth/ith aeanoea?noth oa ii?iae?co? nenoaio IIE-AINC, a oaeiae ai?iiiaeueieo i?aia?ao?a a eiiieaen e?eoaaeueieo caoiae?a i?eaiaeeoue aei cieaeaiiy ??aiy e?ioioeeoioiene/ieo aeeiaioeo?e ? aaoa?io?eueieo aaiie?cei?a, ii?iae?caoe?? ?ioeo iieaciee?a ?ioiiiai noaoono oa i?ioean?a IIE-AINC, ui, iaaii, ni?ey? i?ia?anoaaiith aaa?oiino?. ?acoeueoaoe e?eoaaiiy oa e?iaoeue aaa?oiino? i?inoaaeai? o 104 ?c 127 ae?iie c aanoaoe?eiei i??eiiao?eoii: 100 (96,2%) iaoe??ioie a ?acoeueoao? eiiieaeniiai e?eoaaiiy ia?iaeeee aeeoo?caeaoieo ae?oae. Oaeei /eiii, i?iaaaeaia eiiieaenia aeine?aeaeaiiy iieaciee?a ?ioiiiai, ai?iiiaeueiiai noaoono oa iieaciee?a IIE-AINC o ae?iie c aanoaoe?eiei i??eiiao?eoii aeicaieeei ooi/ieoe iniaeeaino? ao?ieia?? oa iaoiaaiaco, c o?aooaaiiyi yeeo iiaeeeai ?aeiiaiaeoaaoe aeeoa?aioe?eiaaiee i?aeo?ae aei e?eoaaiiy oa c ?aii?o oa?i?i?a i?iaiicoaaoe iniaeeaino? ia?aa?ao aaa?oiino?. Aeniiaee 1. A iaoiaaiac? aanoaoe?eiiai i??eiiao?eoo nooo?ao cia/ei?noue iathoue ?ioiieia?/i?, ai?iiiaeuei? ci?ie, i?ioeane IIE ? AINC (aai ?o niieo/aiiy), ye? aecia/athoue aea?? oa?aiaaoe/ieo caoiae?a. 2. Aaa?oi?noue o ae?iie c aanoaoe?eiei i??eiiao?eoii ia?aa?aa? c ii?ooaiiyi ?ioiiiai noaoono, ui i?iyaey?oueny a ?ioiieia?/iiio aeenaaeain? i?e aino?iio i??eiiao?eo? oa i?eai?/aii? oaeoi??a ?ioi?oaoo i?e o?ii?/iiio i??eiiao?eo?. 3. I?e aanoaoe?eiiio i??eiiao?eo? niinoa??aa?oueny ?ioaineo?eaoe?y i?ioean?a IIE ? cieaeaiiy aeoeaiino? AINC, ui iaea?eueo ae?aaeaii i?e o?ii?/iiio i??eiiao?eo?. 4. Iae?ioi?iaoeai?oeie iieacieeaie aeey i?iaiicoaaiiy e?ioey aaa?oiino? oa eiio?ieth ca e?eoaaiiyi i?e aanoaoe?eiiio i??eiiao?eo? ? ai?no NAe8+ ? NAe16+ ee?oei, ??aaiue e?ioioeeoioiene/ieo aeeiaioeo?e ? aaoa?io?eueieo aaiie?cei?a, iieacieee IIE-AINC, iaoieia?/i? oeie eieueiioeeoia?ai. 5. O aaa?oieo c i??eiiao?eoii a?aei?/a?oueny cieaeaiiy ??aiy aeaio ? a?eueoa ai?iii?a ia iaeia neaiaeueia a?aeoeeaiiy, ui na?ae/eoue i?i iani?eyoeeaee i?iaiic ia?aa?ao aaa?oiino?. 6. Aeeth/aiiy a eiiieaenia e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii ?ineeiiiai i?aia?aoo neooaen ni?ey? ii?iae?caoe?? iieaciee?a ?ioiiiai noaoono, i?eai?/aiith i?ioean?a IIE ? aeoeaaoe?? AINC. 7. Ai?iaaaeaeaiiy a i?aeoeeo aeeoa?aioe?eiaaiiai i?aeoiaeo aei iaoiae?a e?eoaaiiy aanoaoe?eiiai i??eiiao?eoo aeicaieeei caa?aaoe aaa?oi?noue a?eueo i?ae o 96,2% iaoe??ioie. I?AEOE*I? ?AEIIAIAeAOe?? 8. C iaoith i?aeaeuaiiy aoaeoeaiino? oa?ai?? aanoaoe?eiiai i??eiiao?eoo i?e ianoaaeaii? aaa?oieo iaiao?aeii, e??i aecia/aiiy ai?iiiaeueiiai aaeaino, aeyaeyoe iniaeeaino? ?ioiiiai noaoono oa noaio IIE-AINC. 9. Iieacaiiyi aei i?io?eaeoe/iiai e?eoaaiiy ae?iie c aanoaoe?eiei i??eiiao?eoii, iaa?oue i?e a?aenooiino? yaieo ee?i?/ieo iciae ia?a?eaaiiy aaa?oiino?, yaeythoueny: cieaeaiiy ai?noo NAe8+ ? NAe16+ ee?oei, i?aeaeuaiiy ??aiy e?ioioeeoioiene/ieo aeeiaioeo?e ? aaoa?io?eueieo aaiie?cei?a, ?ioaineo?eaoe?y i?ioean?a IIE ? cieaeaiiy aeoeaiino? AINC, iiyaa iaoieia?/ieo oei?a eieueiioeeoia?ai. 10. O ca’yceo c ii?ooaiiyi ?ioiiiai noaoono ? i?ioean?a IIE-AINC i?e aanoaoe?eiiio i??eiiao?eo? a eiiieaenia e?eoaaiiy aaa?oieo ?aeiiaiaeiaaii aeeth/aoe ?ineeiiee i?aia?ao neooaen, ui aieiae?? ?ioiiei?eaoth/ith aeanoea?noth ? ii?iae?co? nenoaio IIE-AINC. 11. Neooaen i?ecia/a?oueny ii 1 oaaeaooe? (0,05 a) 3 ?ace a aeaiue i?ney ?ae? ai?iaeiaae 14 aei?a. I?e a?aenooiino? aoaeoo eo?n e?eoaaiiy i?iaeiaaeo?oueny aei 28 aei?a. NIENIE IIOAE?EIAAIEO I?AOeUe 1. Ua?aaeia A.TH. Iieacieee ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo o ae?iie c aanoaoe?eiei i??eiiao?eoii // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1998. – ?5. – N.80–82. 2. Ua?aaeia A.TH. Eciaiaiea eiioiiiai noaoona aa?aiaiiuo i?e ea/aiee aanoaoeeiiiiai ieaeiiao?eoa // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1998. – Aei. 24. – N.14–18. 3. Ua?aaeia A.TH. ?ieue ieaeiiao?eoia aa?aiaiiuo a ?acaeoee aioo?eoo?iaiiai eioeoee?iaaiey ieiaea / Iaoa??aee I Eiia?ano iaiiaoieia?a Oe?a?ie. – Oa?e?a, 1998. – N.102–104. 4. A?euaiei I.A., Ua?aaeia A.TH. Aanoaoeeiiiue ieaeiiao?eo // Iaaeaeoia?iaeiue iaaeeoeeineee aeo?iae. – 1998. – O.4, ?2. – N.77–81. AIIOAOe?ss Ua?aaeia Aaaeei TH??eiae/. Iaoiaaiaoe/ia iaa?oiooaaiiy ae?aaiinoeee oa e?eoaaiiy aanoaoe?eiiai i??eiiao?eoo. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 – Aeooa?noai ? a?iaeieia?y. - Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?y i?enay/aia ieoaiiyi ae?aaiinoeee oa e?eoaaiiy aanoaoe?eiiai i??eiiao?eoo. I?iaaaeaii eiiieaenia ee?i?ei-eaai?aoi?ia ianoaaeaiiy aaa?oieo c aino?ei oa o?ii?/iei i??eiiao?eoii c iaoith c’ynoaaiiy ?ie? ?ioiiiai aiiainoaco, i?ioean?a ia?aeeniiai ieeneaii? e?i?ae?a ? aeoeaiino? aioeieneaeaioii? nenoaie caoenoo a iaoiaaiac? aanoaoe?eiiai i??eiiao?eoo oa i?aeaeuaiiy aoaeoeaiino? oa?ai??. A ?acoeueoao? aeine?aeaeaiue anoaiiaeaii, ui aeyaeai? ii?ooaiiy ?ioiiiai noaoono, i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a ? aioeieneaeaioii? nenoaie caoenoo iathoue nooo?aa cia/aiiy a ioe?ioe? iniaeeainoae iaoiaaiaco aanoaoe?eiiai i??eiiao?eoo, aeeoa?aioe?eiaaiiai i?aeoiaeo aei i?iaaaeaiiy eiiieaeno e?eoaaeueii-i?io?eaeoe/ieo caoiae?a oa i?iaiicoaaiith e?ioey aaa?oiino?. Ai?iaaaeaeaii iiaee i?aia?ao – neooaen, ui ni?ey? ii?iae?caoe?? ?ioiieo ii?ooaiue, ?ia?ao? ia?aeenia ieeneaiiy e?i?ae?a, ii?iae?co? ooieoe?iiaeueio aeoeai?noue a?iaioeieenethaaeueii? nenoaie, ui cieaeo? /enei ia?eiaoaeueieo ao?ao i?e aanoaoe?eiiio i??eiiao?eo?. Eeth/ia? neiaa: aanoaoe?eiee i??eiiao?eo, ?ioiiee noaoon, ia?aeenia ieeneaiiy e?i?ae?a, aioeieneaeaioia nenoaia caoenoo, neooaen. aiiioaoeey Ua?aaeia Aaaeei TH?ueaae/. Iaoiaaiaoe/aneia iainiiaaiea aeeaaiinoeee e ea/aiey aanoaoeeiiiiai ieaeiiao?eoa. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 – Aeooa?noai e aeiaeieiaey. – Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Aeenna?oaoeey iinayuaia aii?inai iaoiaaiaoe/aneiai iainiiaaiey aeeaaiinoeee e ea/aiey aanoaoeeiiiiai ieaeiiao?eoa. I?iaaaeaiiua enneaaeiaaiey eiioiiiai noaoona i?e aanoaoeeiiiii ieaeiiao?eoa auyaeee ?yae iniaaiiinoae. I?e ino?ii aanoaoeeiiiii ieaeiiao?eoa aaniethoiia eiee/anoai e i?ioeaioiia niaea?aeaiea eeioioeeoia auei ianeieueei oaaee/aii, ioia/aeinue oaaee/aiea aaniethoiiai niaea?aeaiey NAe4+. I?e ioeaiea noaiiioeyoeeiiiiai ninoaaa O-eeaoie auyaeaii nieaeaiea eiioeaio?aoeee O-noi?anni?ia (NAe8+), iaeaieaa au?aaeaiiia i?e o?iie/aneii ieaeiiao?eoa, noaiaiue nieaeaiey iieacaoaey i?e o?iie/aneii ieaeiiao?eoa ii n?aaiaieth n eiio?ieueiie a?oiiie ninoaaeea 1,7 ?aca, i?e ino?ii ieaeiiao?eoa au?aaeaiiinoue eciaiaiey ia i?aauoaea 1,1 ?aca. Aeoeaiinoue anoanoaaiiuo eeeea?ia (NAe16+) nieaeaia eae i?e ino?ii, oae e i?e o?iie/aneii aanoaoeeiiiii ieaeiiao?eoa, i?ioeaio NAe16+ eeaoie i?e o?iie/aneii ieaeiiao?eoa a 1,4 ?aca ieaea, i?e ino?ii – a 1,2 ?aca ieaea, /ai i?e oeceieiae/aneie aa?aiaiiinoe. I?e anao oi?iao ieaeiiao?eoa ioia/aii nieaeaiea A-eeioioeeoia (NAe72+). Eiioeaio?aoeey Ig G i?e ino?ii ieaeiiao?eoa nieaeaia, a Ig A e Ig M eiaea oaiaeaioeeth e iiauoaieth. I?e o?iie/aneii ieaeiiao?eoa ioia/aii nieaeaiea anao eeannia enneaaeoaiuo eiioiiaeiaoeeiia. O?iaaiue eeioioeeoioiene/aneeo aeeiaioeoae a nuai?ioea e?iae aa?aiaiiuo n o?iie/aneei ieaeiiao?eoii aue auoa aeaiiiai iieacaoaey eiio?ieueiie a?oiiu, a aaoa?ioeeueiuo aaiieeceiia, oioy e eiae aeinoiaa?iia ?acee/ea, ii noaiaiue ioee/ee auea iaauniea. ?acoeueoaou eiioiieiae/aneeo enneaaeiaaiee iieacaee, /oi aanoaoeeiiiue ieaeiiao?eo i?aae?aniieaaaao e aeenooieoeee eiioiiie nenoaiu i?e ino?ii ieaeiiao?eoa e oaiaoaieth oaeoi?ia eiioieoaoa i?e o?iie/aneii ieaeiiao?eoa. Aiaeec niaea?aeaiey aeeaiiauo eiiuthaao e iaeiiiaiai aeeaeueaeaaeaea iieacae, /oi iie auee auoa, /ai i?e oeceieiae/aneie aa?aiaiiinoe (AeE a 1,2 ?aca auoa i?e ino?ii e a 1,6 ?aca auoa i?e o?iie/aneii ieaeiiao?eoa, a IAeA a 1,1 e 1,5 ?aca auoa, niioaaonoaaiii, /ai o caei?iauo aa?aiaiiuo). Nei?inoue eiaeooee?iaaiiiai e niiioaiiiai ieeneaiey eeieaeia o aa?aiaiiuo n ino?ui ieaeiiao?eoii oaaee/aia eae a ieacia, oae e a y?eo?ioeeoao (a 1,6 ?aca a ieacia e a 1,3–1,4 ?aca a y?eo?ioeeoao a n?aaiaiee n eiio?ieueiie a?oiiie). O aa?aiaiiuo n o?iie/aneei ieaeiiao?eoii ENIE e NNIE oaeaea oaaee/aia eae a ieacia (a 2,6 e 2,7 ?aca, niioaaonoaaiii), oae e a y?eo?ioeeoao (a 3,1 e 3,5 ?aca, niioaaonoaaiii). Niaea?aeaiea eaoaeacu o aeaiuei n aanoaoeeiiiui ieaeiiao?eoii nieaeaii a 1,6 ?aca i?e ino?ii e a 1,8 ?aca i?e o?iie/aneii ieaeiiao?eoa. A e?iae aa?aiaiiuo n aanoaoeeiiiui ieaeiiao?eoii ioia/aaony nieaeaiea iaueo noeueoaeae?eeueiuo a?oii a 2–3 ?aca ii n?aaiaieth n eo eiee/anoaii o caei?iauo aa?aiaiiuo. O aa?aiaiiuo n aanoaoeeiiiui ieaeiiao?eoii ioia/aaony nieaeaiea o?iaiy aeaoo e aieaa ai?iiiia ia iaeii neaiaeueiia ioeeiiaiea a n?aaiaiee n oeceieiae/aneie aa?aiaiiinoueth. Iaoieiae/aneea oeiu eieueiioeeoia?aii auyaeaiu o 41 (32,3%) aa?aiaiiuo n ieaeiiao?eoii, /oi yaeeinue iniiaaieai aeeth/aiey a eiiieaeniia ea/aiea ai?iiiaeueiuo i?aia?aoia. Aeey ei??aeoeee ia?ooaiee eiioiiie nenoaiu e IIE-AINC a eiiieaeniia ea/aiea aeaiuei n aanoaoeeiiiui ieaeiiao?eoii aeeth/aee ?anoeoaeueiue i?aia?ao neooaen. A ?acoeueoaoa i?iaaaeaiiiai ea/aiey auyaeaii, /oi ii aieueoeinoao eiioiieiae/aneeo ia?aiao?ia oaaee/eaaaony /enei aeaiuei n iieacaoaeyie ?aaiuie ii?ia. E?iia oiai, oaeia oaaee/aiea a iniiaiii i?ienoiaeeo ca n/ao i?aeiouanoaaiiiai eciaiaiey (ii?iaeecaoeee) ia iaeiiai iieacaoaey, a aeaoo e aieaa iaeiia?aiaiii. N?aaeiea aaee/eiu iieacaoaeae a a?oiiao iinea i?iaaaeaiiiai ea/aiey noaiiayony aeeaea e eiio?ieueiui. Iinea i?iaaaeaiiiai ea/aiey eciaieeinue niioiioaiea O/A-eeioioeeoia, ainnoaiiaeeanue eiioeaio?aoeey Ig A, Ig M, Ig G aei o?iaiy caei?iauo aa?aiaiiuo, nieceeny i?ioeaio eeioioeeoioiene/aneeo aioeoae e o?iaaiue aaoa?ioeeueiuo aaiieeceiia, i?iecioei caiaaeeaiea i?ioeannia IIE e aeoeae?iaaeanue AINC, ainnoaiiaeeny ai?iiiaeueiue aaeain. A ?acoeueoaoa i?iaaaeaiiiai ea/aiey 100 (96,2%) iaoeeaioie ?iaeeee aeecianiiniaiuo aeaoae. Oaeei ia?acii, i?iaaaeaiiia eiiieaeniia enneaaeiaaiea eiioiiiai, ai?iiiaeueiiai noaoona, i?ioeannia IIE-AINC o aeaiuei n aanoaoeeiiiui ieaeiiao?eoii iicaieeei ooi/ieoue iniaaiiinoe iaoiaaiaca, n o/aoii eioi?uo aiciiaeii ?aeiiaiaeiaaoue aeeooa?aioee?iaaiiue iiaeoiae e ea/aieth e i?iaiice?iaaoue enoiae aa?aiaiiinoe. Eeth/aaua neiaa: aanoaoeeiiiue ieaeiiao?eo, eiioiiue noaoon, ia?aeeniia ieeneaiea eeieaeia, aioeieneaeaioiay nenoaia caueou, neooaen. annotation Scherbakov Vadim Jurievich. The pathogenetic substantiation diagnostics and treatment of gestation pyelonephritis. – Manuscript Thesis for a candidate degree by specialty 14.01.01 – Obstetrics and Gynecology. – Kharkov State Medical University, Kharkov, 1999. The thesis is devoted to problems of diagnostics and treatment of the gestation pyelonephritis. The complex clinical and laboratory inspection of the pregnant women with acute and chronic pyelonephritis is conducted with the purpose of clearing up of a role of the immune homeostasis, lipids peroxidation and activity of the antyoxydant protective system in pathogeny of gestation pyelonephritis and rising of efficiency of therapy. In the outcome of researches is fixed, that the violations of the immune status, processes of lipids peroxydation and of the antyoxydant protective system have essential value in an evaluation of features of the pathogeny of gestation pyelonephritis, differentiated approach to realization of the complex medical and preventive measures and forecasting of completion of pregnancy. The new preparation Skutex, promoting to normalization of immune violations oppressing of lipids peroxydation, normalizing functional activity of the biological antyoxidant system is introduced, that reduces an amount of perynatal losses. Key words: gestation pyelonephritis, immune status, lipids peroxydation, protective antyoxydant system, Skutex.

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